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Protein

DBF4-type zinc finger-containing protein 2

Gene

ZDBF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 5050DBF4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DBF4-type zinc finger-containing protein 2
Gene namesi
Name:ZDBF2
Synonyms:KIAA1571
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29313. ZDBF2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409574.

Polymorphism and mutation databases

BioMutaiZDBF2.
DMDMi166228734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23542354DBF4-type zinc finger-containing protein 2PRO_0000314166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei539 – 5391PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HCK1.
MaxQBiQ9HCK1.
PaxDbiQ9HCK1.
PeptideAtlasiQ9HCK1.
PRIDEiQ9HCK1.

PTM databases

iPTMnetiQ9HCK1.
PhosphoSiteiQ9HCK1.

Expressioni

Gene expression databases

BgeeiENSG00000204186.
CleanExiHS_ZDBF2.
ExpressionAtlasiQ9HCK1. baseline and differential.
GenevisibleiQ9HCK1. HS.

Organism-specific databases

HPAiHPA039121.
HPA050311.

Interactioni

Protein-protein interaction databases

BioGridi121710. 12 interactions.
IntActiQ9HCK1. 1 interaction.
STRINGi9606.ENSP00000363545.

Structurei

3D structure databases

ProteinModelPortaliQ9HCK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili636 – 66025Sequence analysisAdd
BLAST
Coiled coili1080 – 111031Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi88 – 947Poly-Glu
Compositional biasi2250 – 22534Poly-Lys

Sequence similaritiesi

Contains 1 DBF4-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 5050DBF4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410J2NC. Eukaryota.
ENOG410YJEQ. LUCA.
GeneTreeiENSGT00440000037606.
HOGENOMiHOG000155772.
HOVERGENiHBG108763.
InParanoidiQ9HCK1.
OMAiGRFHCYF.
OrthoDBiEOG091G009E.
PhylomeDBiQ9HCK1.
TreeFamiTF339806.

Family and domain databases

InterProiIPR006572. Znf_DBF.
[Graphical view]
PfamiPF07535. zf-DBF. 1 hit.
[Graphical view]
SMARTiSM00586. ZnF_DBF. 1 hit.
[Graphical view]
PROSITEiPS51265. ZF_DBF4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HCK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKRQGYCSY CRVQYNNLEQ HLFSAQHRSL TRQSRRQICT SSLMERFLQD
60 70 80 90 100
VLQHHPYHCQ ESSSTQDETH VNTGSSSEVV HLDDAFSEEE EEDEDKVEDE
110 120 130 140 150
DATEERPSEV SEPIEELHSR PHKSQEGTQE VSVRPSVIQK LEKGQQQPLE
160 170 180 190 200
FVHKIGASVR KCNLVDIGQA TNNRSNLVRP PVICNAPASC LPESSNDRPV
210 220 230 240 250
TANTTSLPPA AHLDSVSKCD PNKVEKYLEQ PDGASRNPVP SSHVETTSFS
260 270 280 290 300
YQKHKESNRK SLRMNSDKLV LWKDVKSQGK TLSAGLKFHE RMGTKGSLRV
310 320 330 340 350
KSPSKLAVNP NKTDMPSNKG IFEDTIAKNH EEFFSNMDCT QEEKHLVFNK
360 370 380 390 400
TAFWEQKCSV SSEMKFDCIS LQSASDQPQE TAQDLSLWKE EQIDQEDNYE
410 420 430 440 450
SRGSEMSFDC SSSFHSLTDQ SKVSAKEVNL SKEVRTDVQY KNNKSYVSKI
460 470 480 490 500
SSDCDDILHL VTNQSQMIVK EISLQNARHI SLVDQSYESS SSETNFDCDA
510 520 530 540 550
SPQSTSDYPQ QSVTEVNLPK EVHIGLVDKN YGSSSSEVSA DSVFPLQSVV
560 570 580 590 600
DRPPVAVTET KLRKKAHTSL VDNYGSSCSE TSFDCDVSLE SVVDHPQLTV
610 620 630 640 650
KGRNLKGRQV HLKHKKRKPS SAKAHLDCDV SLGTVADESQ RAVEKINLLK
660 670 680 690 700
EKNADLMDMN CESHGPEMGF QADAQLADQS QVAEIERQKV DVDLENKSVQ
710 720 730 740 750
SSRSSLSSDS PASLYHSAHD EPQEALDEVN LKELNIDMEV RSYDCSSSEL
760 770 780 790 800
TFDSDPPLLS VTEQSHLDAE GKERHIDLED ESCESDSSEI TFDSDIPLYS
810 820 830 840 850
VIDQPEVAVY EEETVDLESK SNESCVSEIT FDSDIPLHSG NDHPEVAVKE
860 870 880 890 900
VIQKEEYIHL ERKNDEPSGS EISSDSHAPL HSVTNSPEVA VKKLNPQKEE
910 920 930 940 950
QVHLENKENE PIDSEVSLDY NIIFHSVTGR SEDPIKEISL HTKEHMYLEN
960 970 980 990 1000
KSVFETSLDS DVPLQAATHK PEVIVKETWL QREKHAEFQG RSTEFSGSKT
1010 1020 1030 1040 1050
SLDSGVPHYS VTEPQVAVNK INRKKQYVLE NKNDKCSGSE IILDSNVPPQ
1060 1070 1080 1090 1100
SMTDQPQLAF LKEKHVNLKD KNSKSGDSKI TFDSEQLQEA VKKIDQWKEE
1110 1120 1130 1140 1150
VIGLKNKINE PSTYKLIHHP DVSVQSVADQ PKVAIKHVNL GNENHMYLEV
1160 1170 1180 1190 1200
KNSQYSCSEM NLDSGFLGQS IVNRPQITIL EQEHIELEGK HNQCCGSEVS
1210 1220 1230 1240 1250
FDSDDPLQSV ADRLRETVKE ISLWKDEEVD TEDRRNEAKG FEIMYDSDVL
1260 1270 1280 1290 1300
QPVAGQPEEV VKEVSLWKEH VDLENKIVKP TDSRINFDSH EPLQSVTNKI
1310 1320 1330 1340 1350
PGANKEINLL REEHVCLDDK GYVPSDSEII YVSNIPLQSV IKQPHILEEE
1360 1370 1380 1390 1400
HASLEDKSSN SYSPEESSDS NDSFQAAADE LQKPVKEINL WKEDHIYLED
1410 1420 1430 1440 1450
KSYKLGDFDV SYASHIPVQF VTDQSSVPVK EINLQKKDHN DLENKNCEVC
1460 1470 1480 1490 1500
GSEIKCHSCV HLQSEVDQPQ VSYKEADLQK EEHVVMEEKT DQPSDSEMMY
1510 1520 1530 1540 1550
DSDVPFQIVV NQFPGSVKET HLPKVVLVDL VPGDSDYEVI SDDIPLQLVT
1560 1570 1580 1590 1600
DPPQLTVKDI SCINTECIDI EDKSCDFFGS EVRCNCKAST PSMTNQCKET
1610 1620 1630 1640 1650
FKIINRKKDY IILGEPSCQS CGSEMNFNVD ASDQSMTYES QGPDEKMVKY
1660 1670 1680 1690 1700
IDSEDKSCGY NGSKGKFNLE DTSHRTTHRL QKAHKEASLR KDPRNAGLKG
1710 1720 1730 1740 1750
KSCQSSASAV DFGASSKSAL HRRADKKKRS KLKHRDLEVS CEPDGFEMNF
1760 1770 1780 1790 1800
QCAPPLPSDT DQPQETVKKR HPCKKVSSDL KEKNHDSQSS SVLKVDSVRN
1810 1820 1830 1840 1850
LKKAKDVIED NPDEPVLEAL PHVPPSFVGK TWSQIMREDD IKINALVKEF
1860 1870 1880 1890 1900
REGRFHCYFD DDCETKKVSS KGKKKVTWAD LQGKEDTAPT QAVSESDDIV
1910 1920 1930 1940 1950
CGISDIDDLS VALDKPCHRH PPAERPPKQK GRVASQCQTA KISHSTQTSC
1960 1970 1980 1990 2000
KNYPVMKRKI IRQEEDPPKS KCSRLQDDRK TKKKVKIGTV EFPASCTKVL
2010 2020 2030 2040 2050
KPMQPKALVC VLSSLNIKLK EGEGLPFPKM RHHSWDNDIR FICKYKRNIF
2060 2070 2080 2090 2100
DYYEPLIKQI VISPPLSVIV PEFERRNWVK IHFNRSNQNS SAGDNDADGQ
2110 2120 2130 2140 2150
GSASAPLMAV PARYGFNSHQ GTSDSSLFLE ESKVLHAREL PKKRNFQLTF
2160 2170 2180 2190 2200
LNHDVVKISP KSVRNKLLES QSKKKIHGKR VTTSSNKLGF PKKVYKPIIL
2210 2220 2230 2240 2250
QQKPRKASEK QSIWIRTKPS DIIRKYISKY SVFLRHRYQS RSAFLGRYLK
2260 2270 2280 2290 2300
KKKSVVSRLK KAKRTAKVLL NSSVPPAGAE ELSSAMANPP PKRPVRASCR
2310 2320 2330 2340 2350
VARRRKKTDE SYHGRQKGPS TPVRAYDLRS SSCLQQRERM MTRLANKLRG

NEVK
Length:2,354
Mass (Da):265,618
Last modified:January 15, 2008 - v3
Checksum:i4B72E43A76CED774
GO

Sequence cautioni

The sequence BAC85454 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti160 – 1601R → K.
Corresponds to variant rs10932150 [ dbSNP | Ensembl ].
VAR_037853

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK130893 mRNA. Translation: BAC85454.1. Different initiation.
AK127271 mRNA. No translation available.
AB046791 mRNA. Translation: BAB13397.2.
CCDSiCCDS46501.1.
RefSeqiNP_065974.1. NM_020923.2.
XP_005246768.1. XM_005246711.3.
XP_005246769.1. XM_005246712.4.
XP_005246770.1. XM_005246713.3.
XP_006712719.1. XM_006712656.3.
XP_011509834.1. XM_011511532.2.
XP_011509835.1. XM_011511533.2.
XP_011509836.1. XM_011511534.2.
XP_011509837.1. XM_011511535.2.
UniGeneiHs.110489.

Genome annotation databases

EnsembliENST00000374423; ENSP00000363545; ENSG00000204186.
GeneIDi57683.
KEGGihsa:57683.
UCSCiuc002vbp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK130893 mRNA. Translation: BAC85454.1. Different initiation.
AK127271 mRNA. No translation available.
AB046791 mRNA. Translation: BAB13397.2.
CCDSiCCDS46501.1.
RefSeqiNP_065974.1. NM_020923.2.
XP_005246768.1. XM_005246711.3.
XP_005246769.1. XM_005246712.4.
XP_005246770.1. XM_005246713.3.
XP_006712719.1. XM_006712656.3.
XP_011509834.1. XM_011511532.2.
XP_011509835.1. XM_011511533.2.
XP_011509836.1. XM_011511534.2.
XP_011509837.1. XM_011511535.2.
UniGeneiHs.110489.

3D structure databases

ProteinModelPortaliQ9HCK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121710. 12 interactions.
IntActiQ9HCK1. 1 interaction.
STRINGi9606.ENSP00000363545.

PTM databases

iPTMnetiQ9HCK1.
PhosphoSiteiQ9HCK1.

Polymorphism and mutation databases

BioMutaiZDBF2.
DMDMi166228734.

Proteomic databases

EPDiQ9HCK1.
MaxQBiQ9HCK1.
PaxDbiQ9HCK1.
PeptideAtlasiQ9HCK1.
PRIDEiQ9HCK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374423; ENSP00000363545; ENSG00000204186.
GeneIDi57683.
KEGGihsa:57683.
UCSCiuc002vbp.4. human.

Organism-specific databases

CTDi57683.
GeneCardsiZDBF2.
H-InvDBHIX0002772.
HIX0161888.
HGNCiHGNC:29313. ZDBF2.
HPAiHPA039121.
HPA050311.
neXtProtiNX_Q9HCK1.
PharmGKBiPA162409574.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2NC. Eukaryota.
ENOG410YJEQ. LUCA.
GeneTreeiENSGT00440000037606.
HOGENOMiHOG000155772.
HOVERGENiHBG108763.
InParanoidiQ9HCK1.
OMAiGRFHCYF.
OrthoDBiEOG091G009E.
PhylomeDBiQ9HCK1.
TreeFamiTF339806.

Miscellaneous databases

ChiTaRSiZDBF2. human.
GenomeRNAii57683.
PROiQ9HCK1.

Gene expression databases

BgeeiENSG00000204186.
CleanExiHS_ZDBF2.
ExpressionAtlasiQ9HCK1. baseline and differential.
GenevisibleiQ9HCK1. HS.

Family and domain databases

InterProiIPR006572. Znf_DBF.
[Graphical view]
PfamiPF07535. zf-DBF. 1 hit.
[Graphical view]
SMARTiSM00586. ZnF_DBF. 1 hit.
[Graphical view]
PROSITEiPS51265. ZF_DBF4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDBF2_HUMAN
AccessioniPrimary (citable) accession number: Q9HCK1
Secondary accession number(s): Q6ZNP7, Q6ZSN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.