Q9HCK0 (ZBT26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 26

Alternative name(s):
Zinc finger protein 481
Zinc finger protein Bioref

Gene names

Name:	ZBTB26
Synonyms:	KIAA1572, ZNF481

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Tissue specificity	Ubiquitous.
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 4 C2H2-type zinc fingers.
Sequence caution	The sequence BAB13398.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	Zinc finger and BTB domain-containing protein 26		PRO_0000047739
Regions
	Domain	33 – 97	65	BTB
	Zinc finger	273 – 295	23	C2H2-type 1
	Zinc finger	298 – 320	23	C2H2-type 2
	Zinc finger	326 – 348	23	C2H2-type 3
	Zinc finger	354 – 377	24	C2H2-type 4
Natural variations
	Natural variant	236	1	H → R. Corresponds to variant rs7856488 [ dbSNP | Ensembl ].		VAR_052916

Sequences

	Sequence		Length	Mass (Da)
	Q9HCK0 [UniParc]. Last modified April 16, 2002. Version 2. Checksum: AC89C960820BEC83	FASTA	441	49,953
	10 20 30 40 50 60 MSERSDLLHF KFENYGDSML QKMNKLREEN KFCDVTVLID DIEVQGHKIV FAAGSPFLRD 70 80 90 100 110 120 QFLLNDSREV KISILQSSEV GRQLLLSCYS GVLEFPEMEL VNYLTAASFL QMSHIVERCT 130 140 150 160 170 180 QALWKFIKPK QPMDSKEGCE PQSASPQSKE QQGDARGSPK QDSPCIHPSE DSMDMEDSDI 190 200 210 220 230 240 QIVKVESIGD VSEVRSKKDQ NQFISSEPTA LHSSEPQHSL INSTVENRVS EIEQNHLHNY 250 260 270 280 290 300 ALSYTGSDNI IMASKDVFGP NIRGVDKGLQ WHHQCPKCTR VFRHLENYAN HLKMHKLFMC 310 320 330 340 350 360 LLCGKTFTQK GNLHRHMRVH AGIKPFQCKI CGKTFSQKCS LQDHLNLHSG DKPHKCNYCD 370 380 390 400 410 420 MVFAHKPVLR KHLKQLHGKN SFDNANERNV QDLTVDFDSF ACTTVTDSKG CQPQPDATQV 430 440 LDAGKLAQAV LNLRNDSTCV N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bioref, a novel bioregulating factor ubiquitously expressed." Alliel P.M., Goudou D., Seddiqi N., Rieger F., Perin J.-P. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed: 10997877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF323460 mRNA. Translation: AAL55969.1. AB046792 mRNA. Translation: BAB13398.1. Different initiation. AK057445 mRNA. Translation: BAG51915.1. BC018748 mRNA. Translation: AAH18748.1.
IPI	IPI00017087.
RefSeq	NP_065975.1. NM_020924.2.
UniGene	Hs.5638.
3D structure databases
ProteinModelPortal	Q9HCK0.
SMR	Q9HCK0. Positions 5-125, 269-380.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HCK0. 2 interactions.
Polymorphism databases
DMDM	20177845.
Proteomic databases
PRIDE	Q9HCK0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373654; ENSP00000362758; ENSG00000171448. ENST00000373656; ENSP00000362760; ENSG00000171448.
GeneID	57684.
KEGG	hsa:57684.
UCSC	uc004bni.2. human.
Organism-specific databases
CTD	57684.
GeneCards	GC09M125677.
H-InvDB	HIX0008359.
HGNC	HGNC:23383. ZBTB26.
HPA	HPA021444.
neXtProt	NX_Q9HCK0.
PharmGKB	PA134914020.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07542.
GeneTree	ENSGT00580000081322.
HOGENOM	HBG714890.
HOVERGEN	HBG056199.
InParanoid	Q9HCK0.
OMA	QPSEDSM.
OrthoDB	EOG4CJVHF.
PhylomeDB	Q9HCK0.
Gene expression databases
ArrayExpress	Q9HCK0.
Bgee	Q9HCK0.
CleanEx	HS_ZBTB26.
Genevestigator	Q9HCK0.
GermOnline	ENSG00000171448. Homo sapiens.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.
KO	K10505.
Pfam	PF00651. BTB. 1 hit. PF00096. zf-C2H2. 4 hits. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 4 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	64506.

Entry information

Entry name

ZBT26_HUMAN

Accession

Primary (citable) accession number: Q9HCK0
Secondary accession number(s): B3KQ53, Q8WTR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	April 16, 2002
Last modified:	January 25, 2012
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.