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Protein

Zinc finger and BTB domain-containing protein 26

Gene

ZBTB26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri273 – 295C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 377C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171448-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 26
Alternative name(s):
Zinc finger protein 481
Zinc finger protein Bioref
Gene namesi
Name:ZBTB26
Synonyms:KIAA1572, ZNF481
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23383. ZBTB26.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171448.
PharmGKBiPA134914020.

Polymorphism and mutation databases

BioMutaiZBTB26.
DMDMi20177845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477391 – 441Zinc finger and BTB domain-containing protein 26Add BLAST441

Proteomic databases

EPDiQ9HCK0.
MaxQBiQ9HCK0.
PaxDbiQ9HCK0.
PeptideAtlasiQ9HCK0.
PRIDEiQ9HCK0.

PTM databases

iPTMnetiQ9HCK0.
PhosphoSitePlusiQ9HCK0.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000171448.
CleanExiHS_ZBTB26.
GenevisibleiQ9HCK0. HS.

Organism-specific databases

HPAiHPA021444.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-3918996,EBI-3918996
G2XKQ05EBI-3918996,EBI-10175576
GIPC2Q8TF653EBI-3918996,EBI-712067
HEL164V9HWH03EBI-3918996,EBI-10330301
SUMO1P631655EBI-3918996,EBI-80140
UBE2IP632793EBI-3918996,EBI-80168
ZBTB6Q159165EBI-3918996,EBI-7227791

Protein-protein interaction databases

BioGridi121711. 9 interactors.
IntActiQ9HCK0. 30 interactors.
STRINGi9606.ENSP00000362758.

Structurei

3D structure databases

ProteinModelPortaliQ9HCK0.
SMRiQ9HCK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 97BTBPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri273 – 295C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 377C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000232051.
HOVERGENiHBG056199.
InParanoidiQ9HCK0.
KOiK10505.
OMAiHIVEQCT.
OrthoDBiEOG091G072A.
PhylomeDBiQ9HCK0.
TreeFamiTF333162.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HCK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERSDLLHF KFENYGDSML QKMNKLREEN KFCDVTVLID DIEVQGHKIV
60 70 80 90 100
FAAGSPFLRD QFLLNDSREV KISILQSSEV GRQLLLSCYS GVLEFPEMEL
110 120 130 140 150
VNYLTAASFL QMSHIVERCT QALWKFIKPK QPMDSKEGCE PQSASPQSKE
160 170 180 190 200
QQGDARGSPK QDSPCIHPSE DSMDMEDSDI QIVKVESIGD VSEVRSKKDQ
210 220 230 240 250
NQFISSEPTA LHSSEPQHSL INSTVENRVS EIEQNHLHNY ALSYTGSDNI
260 270 280 290 300
IMASKDVFGP NIRGVDKGLQ WHHQCPKCTR VFRHLENYAN HLKMHKLFMC
310 320 330 340 350
LLCGKTFTQK GNLHRHMRVH AGIKPFQCKI CGKTFSQKCS LQDHLNLHSG
360 370 380 390 400
DKPHKCNYCD MVFAHKPVLR KHLKQLHGKN SFDNANERNV QDLTVDFDSF
410 420 430 440
ACTTVTDSKG CQPQPDATQV LDAGKLAQAV LNLRNDSTCV N
Length:441
Mass (Da):49,953
Last modified:April 16, 2002 - v2
Checksum:iAC89C960820BEC83
GO

Sequence cautioni

The sequence BAB13398 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052916236H → R.Corresponds to variant rs7856488dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323460 mRNA. Translation: AAL55969.1.
AB046792 mRNA. Translation: BAB13398.1. Different initiation.
AK057445 mRNA. Translation: BAG51915.1.
BC018748 mRNA. Translation: AAH18748.1.
CCDSiCCDS6847.1.
RefSeqiNP_001291292.1. NM_001304363.1.
NP_001291293.1. NM_001304364.1.
NP_065975.1. NM_020924.3.
UniGeneiHs.5638.
Hs.617843.

Genome annotation databases

EnsembliENST00000373654; ENSP00000362758; ENSG00000171448.
ENST00000373656; ENSP00000362760; ENSG00000171448.
GeneIDi57684.
KEGGihsa:57684.
UCSCiuc004bnj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323460 mRNA. Translation: AAL55969.1.
AB046792 mRNA. Translation: BAB13398.1. Different initiation.
AK057445 mRNA. Translation: BAG51915.1.
BC018748 mRNA. Translation: AAH18748.1.
CCDSiCCDS6847.1.
RefSeqiNP_001291292.1. NM_001304363.1.
NP_001291293.1. NM_001304364.1.
NP_065975.1. NM_020924.3.
UniGeneiHs.5638.
Hs.617843.

3D structure databases

ProteinModelPortaliQ9HCK0.
SMRiQ9HCK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121711. 9 interactors.
IntActiQ9HCK0. 30 interactors.
STRINGi9606.ENSP00000362758.

PTM databases

iPTMnetiQ9HCK0.
PhosphoSitePlusiQ9HCK0.

Polymorphism and mutation databases

BioMutaiZBTB26.
DMDMi20177845.

Proteomic databases

EPDiQ9HCK0.
MaxQBiQ9HCK0.
PaxDbiQ9HCK0.
PeptideAtlasiQ9HCK0.
PRIDEiQ9HCK0.

Protocols and materials databases

DNASUi57684.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373654; ENSP00000362758; ENSG00000171448.
ENST00000373656; ENSP00000362760; ENSG00000171448.
GeneIDi57684.
KEGGihsa:57684.
UCSCiuc004bnj.4. human.

Organism-specific databases

CTDi57684.
GeneCardsiZBTB26.
HGNCiHGNC:23383. ZBTB26.
HPAiHPA021444.
neXtProtiNX_Q9HCK0.
OpenTargetsiENSG00000171448.
PharmGKBiPA134914020.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000232051.
HOVERGENiHBG056199.
InParanoidiQ9HCK0.
KOiK10505.
OMAiHIVEQCT.
OrthoDBiEOG091G072A.
PhylomeDBiQ9HCK0.
TreeFamiTF333162.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171448-MONOMER.

Miscellaneous databases

GenomeRNAii57684.
PROiQ9HCK0.

Gene expression databases

BgeeiENSG00000171448.
CleanExiHS_ZBTB26.
GenevisibleiQ9HCK0. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT26_HUMAN
AccessioniPrimary (citable) accession number: Q9HCK0
Secondary accession number(s): B3KQ53, Q8WTR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 16, 2002
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.