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Protein

Zinc finger and BTB domain-containing protein 26

Gene

ZBTB26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri273 – 295C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 377C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 26
Alternative name(s):
Zinc finger protein 481
Zinc finger protein Bioref
Gene namesi
Name:ZBTB26
Synonyms:KIAA1572, ZNF481
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000171448.8.
HGNCiHGNC:23383. ZBTB26.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171448.
PharmGKBiPA134914020.

Polymorphism and mutation databases

BioMutaiZBTB26.
DMDMi20177845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477391 – 441Zinc finger and BTB domain-containing protein 26Add BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki184Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki255Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki329Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9HCK0.
MaxQBiQ9HCK0.
PaxDbiQ9HCK0.
PeptideAtlasiQ9HCK0.
PRIDEiQ9HCK0.

PTM databases

iPTMnetiQ9HCK0.
PhosphoSitePlusiQ9HCK0.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000171448.
CleanExiHS_ZBTB26.
GenevisibleiQ9HCK0. HS.

Organism-specific databases

HPAiHPA021444.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi121711. 9 interactors.
IntActiQ9HCK0. 32 interactors.
STRINGi9606.ENSP00000362758.

Structurei

3D structure databases

ProteinModelPortaliQ9HCK0.
SMRiQ9HCK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 97BTBPROSITE-ProRule annotationAdd BLAST65

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri273 – 295C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 377C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000232051.
HOVERGENiHBG056199.
InParanoidiQ9HCK0.
KOiK10505.
OMAiKPHRCNY.
OrthoDBiEOG091G072A.
PhylomeDBiQ9HCK0.
TreeFamiTF333162.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF00651. BTB. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q9HCK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERSDLLHF KFENYGDSML QKMNKLREEN KFCDVTVLID DIEVQGHKIV
60 70 80 90 100
FAAGSPFLRD QFLLNDSREV KISILQSSEV GRQLLLSCYS GVLEFPEMEL
110 120 130 140 150
VNYLTAASFL QMSHIVERCT QALWKFIKPK QPMDSKEGCE PQSASPQSKE
160 170 180 190 200
QQGDARGSPK QDSPCIHPSE DSMDMEDSDI QIVKVESIGD VSEVRSKKDQ
210 220 230 240 250
NQFISSEPTA LHSSEPQHSL INSTVENRVS EIEQNHLHNY ALSYTGSDNI
260 270 280 290 300
IMASKDVFGP NIRGVDKGLQ WHHQCPKCTR VFRHLENYAN HLKMHKLFMC
310 320 330 340 350
LLCGKTFTQK GNLHRHMRVH AGIKPFQCKI CGKTFSQKCS LQDHLNLHSG
360 370 380 390 400
DKPHKCNYCD MVFAHKPVLR KHLKQLHGKN SFDNANERNV QDLTVDFDSF
410 420 430 440
ACTTVTDSKG CQPQPDATQV LDAGKLAQAV LNLRNDSTCV N
Length:441
Mass (Da):49,953
Last modified:April 16, 2002 - v2
Checksum:iAC89C960820BEC83
GO

Sequence cautioni

The sequence BAB13398 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052916236H → R. Corresponds to variant dbSNP:rs7856488Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323460 mRNA. Translation: AAL55969.1.
AB046792 mRNA. Translation: BAB13398.1. Different initiation.
AK057445 mRNA. Translation: BAG51915.1.
BC018748 mRNA. Translation: AAH18748.1.
CCDSiCCDS6847.1.
RefSeqiNP_001291292.1. NM_001304363.1.
NP_001291293.1. NM_001304364.1.
NP_065975.1. NM_020924.3.
UniGeneiHs.5638.
Hs.617843.

Genome annotation databases

EnsembliENST00000373654; ENSP00000362758; ENSG00000171448.
ENST00000373656; ENSP00000362760; ENSG00000171448.
GeneIDi57684.
KEGGihsa:57684.
UCSCiuc004bnj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZBT26_HUMAN
AccessioniPrimary (citable) accession number: Q9HCK0
Secondary accession number(s): B3KQ53, Q8WTR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 16, 2002
Last modified: November 22, 2017
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations