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Protein

Synaptic vesicle membrane protein VAT-1 homolog-like

Gene

VAT1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle membrane protein VAT-1 homolog-like (EC:1.-.-.-)
Gene namesi
Name:VAT1L
Synonyms:KIAA1576
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29315. VAT1L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164727497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Synaptic vesicle membrane protein VAT-1 homolog-likePRO_0000160922Add
BLAST

Proteomic databases

MaxQBiQ9HCJ6.
PaxDbiQ9HCJ6.
PeptideAtlasiQ9HCJ6.
PRIDEiQ9HCJ6.

PTM databases

PhosphoSiteiQ9HCJ6.

Expressioni

Tissue specificityi

Detected in skin fibroblasts.1 Publication

Gene expression databases

BgeeiQ9HCJ6.
CleanExiHS_VAT1L.
ExpressionAtlasiQ9HCJ6. baseline and differential.
GenevestigatoriQ9HCJ6.

Organism-specific databases

HPAiCAB046032.
HPA044061.

Interactioni

Protein-protein interaction databases

BioGridi121713. 3 interactions.
STRINGi9606.ENSP00000303129.

Structurei

Secondary structure

1
419
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi42 – 476Combined sources
Beta strandi49 – 524Combined sources
Helixi53 – 553Combined sources
Beta strandi56 – 616Combined sources
Beta strandi70 – 8011Combined sources
Helixi82 – 898Combined sources
Beta strandi92 – 943Combined sources
Beta strandi98 – 1003Combined sources
Beta strandi104 – 11310Combined sources
Beta strandi125 – 1295Combined sources
Beta strandi135 – 1428Combined sources
Helixi143 – 1453Combined sources
Beta strandi146 – 1483Combined sources
Helixi155 – 1595Combined sources
Helixi162 – 17312Combined sources
Beta strandi183 – 1886Combined sources
Helixi192 – 20110Combined sources
Beta strandi208 – 2136Combined sources
Helixi215 – 2173Combined sources
Helixi218 – 2214Combined sources
Helixi222 – 2243Combined sources
Beta strandi225 – 2306Combined sources
Helixi235 – 2428Combined sources
Beta strandi247 – 2537Combined sources
Beta strandi266 – 27510Combined sources
Helixi303 – 3097Combined sources
Beta strandi312 – 3165Combined sources
Helixi318 – 3236Combined sources
Helixi328 – 34316Combined sources
Beta strandi351 – 3555Combined sources
Helixi357 – 3593Combined sources
Helixi360 – 3689Combined sources
Beta strandi373 – 3797Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A27X-ray2.10A/B41-387[»]
ProteinModelPortaliQ9HCJ6.
SMRiQ9HCJ6. Positions 39-384.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCJ6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294681.
HOVERGENiHBG002466.
InParanoidiQ9HCJ6.
OMAiDSENKER.
OrthoDBiEOG7VQJD4.
PhylomeDBiQ9HCJ6.
TreeFamiTF314255.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HCJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEGVEKAE ETEQMIEKEA GKEPAEGGGG DGSHRLGDAQ EMRAVVLAGF
60 70 80 90 100
GGLNKLRLFR KAMPEPQDGE LKIRVKACGL NFIDLMVRQG NIDNPPKTPL
110 120 130 140 150
VPGFECSGIV EALGDSVKGY EIGDRVMAFV NYNAWAEVVC TPVEFVYKIP
160 170 180 190 200
DDMSFSEAAA FPMNFVTAYV MLFEVANLRE GMSVLVHSAG GGVGQAVAQL
210 220 230 240 250
CSTVPNVTVF GTASTFKHEA IKDSVTHLFD RNADYVQEVK RISAEGVDIV
260 270 280 290 300
LDCLCGDNTG KGLSLLKPLG TYILYGSSNM VTGETKSFFS FAKSWWQVEK
310 320 330 340 350
VNPIKLYEEN KVIAGFSLLN LLFKQGRAGL IRGVVEKLIG LYNQKKIKPV
360 370 380 390 400
VDSLWALEEV KEAMQRIHDR GNIGKLILDV EKTPTPLMAN DSTETSEAGE
410
EEEDHEGDSE NKERMPFIQ
Length:419
Mass (Da):45,899
Last modified:September 26, 2004 - v2
Checksum:iBA962924662987AC
GO

Sequence cautioni

The sequence BAB13402.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046796 mRNA. Translation: BAB13402.1. Different initiation.
BC033537 mRNA. Translation: AAH33537.1.
CCDSiCCDS32492.1.
RefSeqiNP_065978.1. NM_020927.2.
UniGeneiHs.461405.

Genome annotation databases

EnsembliENST00000302536; ENSP00000303129; ENSG00000171724.
GeneIDi57687.
KEGGihsa:57687.
UCSCiuc002ffg.1. human.

Polymorphism databases

DMDMi52783098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046796 mRNA. Translation: BAB13402.1. Different initiation.
BC033537 mRNA. Translation: AAH33537.1.
CCDSiCCDS32492.1.
RefSeqiNP_065978.1. NM_020927.2.
UniGeneiHs.461405.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A27X-ray2.10A/B41-387[»]
ProteinModelPortaliQ9HCJ6.
SMRiQ9HCJ6. Positions 39-384.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121713. 3 interactions.
STRINGi9606.ENSP00000303129.

PTM databases

PhosphoSiteiQ9HCJ6.

Polymorphism databases

DMDMi52783098.

Proteomic databases

MaxQBiQ9HCJ6.
PaxDbiQ9HCJ6.
PeptideAtlasiQ9HCJ6.
PRIDEiQ9HCJ6.

Protocols and materials databases

DNASUi57687.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302536; ENSP00000303129; ENSG00000171724.
GeneIDi57687.
KEGGihsa:57687.
UCSCiuc002ffg.1. human.

Organism-specific databases

CTDi57687.
GeneCardsiGC16P077822.
HGNCiHGNC:29315. VAT1L.
HPAiCAB046032.
HPA044061.
neXtProtiNX_Q9HCJ6.
PharmGKBiPA164727497.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294681.
HOVERGENiHBG002466.
InParanoidiQ9HCJ6.
OMAiDSENKER.
OrthoDBiEOG7VQJD4.
PhylomeDBiQ9HCJ6.
TreeFamiTF314255.

Miscellaneous databases

ChiTaRSiVAT1L. human.
EvolutionaryTraceiQ9HCJ6.
GenomeRNAii57687.
NextBioi64514.
PROiQ9HCJ6.

Gene expression databases

BgeeiQ9HCJ6.
CleanExiHS_VAT1L.
ExpressionAtlasiQ9HCJ6. baseline and differential.
GenevestigatoriQ9HCJ6.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects."
    Dastani Z., Pajukanta P., Marcil M., Rudzicz N., Ruel I., Bailey S.D., Lee J.C., Lemire M., Faith J., Platko J., Rioux J., Hudson T.J., Gaudet D., Engert J.C., Genest J.
    Eur. J. Hum. Genet. 18:342-347(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Crystal structure of human synaptic vesicle membrane protein Vat-1 homolog-like protein."
    Structural genomics consortium (SGC)
    Submitted (AUG-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 41-387.

Entry informationi

Entry nameiVAT1L_HUMAN
AccessioniPrimary (citable) accession number: Q9HCJ6
Secondary accession number(s): Q8IYW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2004
Last sequence update: September 26, 2004
Last modified: March 3, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.