Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9HCJ6

- VAT1L_HUMAN

UniProt

Q9HCJ6 - VAT1L_HUMAN

Protein

Synaptic vesicle membrane protein VAT-1 homolog-like

Gene

VAT1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (27 Sep 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW
    2. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptic vesicle membrane protein VAT-1 homolog-like (EC:1.-.-.-)
    Gene namesi
    Name:VAT1L
    Synonyms:KIAA1576
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:29315. VAT1L.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164727497.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 419419Synaptic vesicle membrane protein VAT-1 homolog-likePRO_0000160922Add
    BLAST

    Proteomic databases

    MaxQBiQ9HCJ6.
    PaxDbiQ9HCJ6.
    PeptideAtlasiQ9HCJ6.
    PRIDEiQ9HCJ6.

    PTM databases

    PhosphoSiteiQ9HCJ6.

    Expressioni

    Tissue specificityi

    Detected in skin fibroblasts.1 Publication

    Gene expression databases

    ArrayExpressiQ9HCJ6.
    BgeeiQ9HCJ6.
    CleanExiHS_VAT1L.
    GenevestigatoriQ9HCJ6.

    Organism-specific databases

    HPAiCAB046032.
    HPA044061.

    Interactioni

    Protein-protein interaction databases

    BioGridi121713. 2 interactions.
    STRINGi9606.ENSP00000303129.

    Structurei

    Secondary structure

    1
    419
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi42 – 476
    Beta strandi49 – 524
    Helixi53 – 553
    Beta strandi56 – 616
    Beta strandi70 – 8011
    Helixi82 – 898
    Beta strandi92 – 943
    Beta strandi98 – 1003
    Beta strandi104 – 11310
    Beta strandi125 – 1295
    Beta strandi135 – 1428
    Helixi143 – 1453
    Beta strandi146 – 1483
    Helixi155 – 1595
    Helixi162 – 17312
    Beta strandi183 – 1886
    Helixi192 – 20110
    Beta strandi208 – 2136
    Helixi215 – 2173
    Helixi218 – 2214
    Helixi222 – 2243
    Beta strandi225 – 2306
    Helixi235 – 2428
    Beta strandi247 – 2537
    Beta strandi266 – 27510
    Helixi303 – 3097
    Beta strandi312 – 3165
    Helixi318 – 3236
    Helixi328 – 34316
    Beta strandi351 – 3555
    Helixi357 – 3593
    Helixi360 – 3689
    Beta strandi373 – 3797

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4A27X-ray2.10A/B41-387[»]
    ProteinModelPortaliQ9HCJ6.
    SMRiQ9HCJ6. Positions 39-384.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9HCJ6.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0604.
    HOGENOMiHOG000294681.
    HOVERGENiHBG002466.
    InParanoidiQ9HCJ6.
    OMAiDSENKER.
    OrthoDBiEOG7VQJD4.
    PhylomeDBiQ9HCJ6.
    TreeFamiTF314255.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    IPR002364. Quin_OxRdtase/zeta-crystal_CS.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.
    PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HCJ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKEGVEKAE ETEQMIEKEA GKEPAEGGGG DGSHRLGDAQ EMRAVVLAGF    50
    GGLNKLRLFR KAMPEPQDGE LKIRVKACGL NFIDLMVRQG NIDNPPKTPL 100
    VPGFECSGIV EALGDSVKGY EIGDRVMAFV NYNAWAEVVC TPVEFVYKIP 150
    DDMSFSEAAA FPMNFVTAYV MLFEVANLRE GMSVLVHSAG GGVGQAVAQL 200
    CSTVPNVTVF GTASTFKHEA IKDSVTHLFD RNADYVQEVK RISAEGVDIV 250
    LDCLCGDNTG KGLSLLKPLG TYILYGSSNM VTGETKSFFS FAKSWWQVEK 300
    VNPIKLYEEN KVIAGFSLLN LLFKQGRAGL IRGVVEKLIG LYNQKKIKPV 350
    VDSLWALEEV KEAMQRIHDR GNIGKLILDV EKTPTPLMAN DSTETSEAGE 400
    EEEDHEGDSE NKERMPFIQ 419
    Length:419
    Mass (Da):45,899
    Last modified:September 27, 2004 - v2
    Checksum:iBA962924662987AC
    GO

    Sequence cautioni

    The sequence BAB13402.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046796 mRNA. Translation: BAB13402.1. Different initiation.
    BC033537 mRNA. Translation: AAH33537.1.
    CCDSiCCDS32492.1.
    RefSeqiNP_065978.1. NM_020927.1.
    UniGeneiHs.461405.

    Genome annotation databases

    EnsembliENST00000302536; ENSP00000303129; ENSG00000171724.
    GeneIDi57687.
    KEGGihsa:57687.
    UCSCiuc002ffg.1. human.

    Polymorphism databases

    DMDMi52783098.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046796 mRNA. Translation: BAB13402.1 . Different initiation.
    BC033537 mRNA. Translation: AAH33537.1 .
    CCDSi CCDS32492.1.
    RefSeqi NP_065978.1. NM_020927.1.
    UniGenei Hs.461405.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4A27 X-ray 2.10 A/B 41-387 [» ]
    ProteinModelPortali Q9HCJ6.
    SMRi Q9HCJ6. Positions 39-384.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121713. 2 interactions.
    STRINGi 9606.ENSP00000303129.

    PTM databases

    PhosphoSitei Q9HCJ6.

    Polymorphism databases

    DMDMi 52783098.

    Proteomic databases

    MaxQBi Q9HCJ6.
    PaxDbi Q9HCJ6.
    PeptideAtlasi Q9HCJ6.
    PRIDEi Q9HCJ6.

    Protocols and materials databases

    DNASUi 57687.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302536 ; ENSP00000303129 ; ENSG00000171724 .
    GeneIDi 57687.
    KEGGi hsa:57687.
    UCSCi uc002ffg.1. human.

    Organism-specific databases

    CTDi 57687.
    GeneCardsi GC16P077822.
    HGNCi HGNC:29315. VAT1L.
    HPAi CAB046032.
    HPA044061.
    neXtProti NX_Q9HCJ6.
    PharmGKBi PA164727497.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0604.
    HOGENOMi HOG000294681.
    HOVERGENi HBG002466.
    InParanoidi Q9HCJ6.
    OMAi DSENKER.
    OrthoDBi EOG7VQJD4.
    PhylomeDBi Q9HCJ6.
    TreeFami TF314255.

    Miscellaneous databases

    ChiTaRSi VAT1L. human.
    EvolutionaryTracei Q9HCJ6.
    GenomeRNAii 57687.
    NextBioi 64514.
    PROi Q9HCJ6.

    Gene expression databases

    ArrayExpressi Q9HCJ6.
    Bgeei Q9HCJ6.
    CleanExi HS_VAT1L.
    Genevestigatori Q9HCJ6.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    IPR002364. Quin_OxRdtase/zeta-crystal_CS.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    PROSITEi PS01162. QOR_ZETA_CRYSTAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects."
      Dastani Z., Pajukanta P., Marcil M., Rudzicz N., Ruel I., Bailey S.D., Lee J.C., Lemire M., Faith J., Platko J., Rioux J., Hudson T.J., Gaudet D., Engert J.C., Genest J.
      Eur. J. Hum. Genet. 18:342-347(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. "Crystal structure of human synaptic vesicle membrane protein Vat-1 homolog-like protein."
      Structural genomics consortium (SGC)
      Submitted (SEP-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 41-387.

    Entry informationi

    Entry nameiVAT1L_HUMAN
    AccessioniPrimary (citable) accession number: Q9HCJ6
    Secondary accession number(s): Q8IYW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3