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Q9HCJ6

- VAT1L_HUMAN

UniProt

Q9HCJ6 - VAT1L_HUMAN

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Protein

Synaptic vesicle membrane protein VAT-1 homolog-like

Gene

VAT1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle membrane protein VAT-1 homolog-like (EC:1.-.-.-)
Gene namesi
Name:VAT1L
Synonyms:KIAA1576
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:29315. VAT1L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164727497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Synaptic vesicle membrane protein VAT-1 homolog-likePRO_0000160922Add
BLAST

Proteomic databases

MaxQBiQ9HCJ6.
PaxDbiQ9HCJ6.
PeptideAtlasiQ9HCJ6.
PRIDEiQ9HCJ6.

PTM databases

PhosphoSiteiQ9HCJ6.

Expressioni

Tissue specificityi

Detected in skin fibroblasts.1 Publication

Gene expression databases

BgeeiQ9HCJ6.
CleanExiHS_VAT1L.
ExpressionAtlasiQ9HCJ6. baseline and differential.
GenevestigatoriQ9HCJ6.

Organism-specific databases

HPAiCAB046032.
HPA044061.

Interactioni

Protein-protein interaction databases

BioGridi121713. 2 interactions.
STRINGi9606.ENSP00000303129.

Structurei

Secondary structure

1
419
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi42 – 476
Beta strandi49 – 524
Helixi53 – 553
Beta strandi56 – 616
Beta strandi70 – 8011
Helixi82 – 898
Beta strandi92 – 943
Beta strandi98 – 1003
Beta strandi104 – 11310
Beta strandi125 – 1295
Beta strandi135 – 1428
Helixi143 – 1453
Beta strandi146 – 1483
Helixi155 – 1595
Helixi162 – 17312
Beta strandi183 – 1886
Helixi192 – 20110
Beta strandi208 – 2136
Helixi215 – 2173
Helixi218 – 2214
Helixi222 – 2243
Beta strandi225 – 2306
Helixi235 – 2428
Beta strandi247 – 2537
Beta strandi266 – 27510
Helixi303 – 3097
Beta strandi312 – 3165
Helixi318 – 3236
Helixi328 – 34316
Beta strandi351 – 3555
Helixi357 – 3593
Helixi360 – 3689
Beta strandi373 – 3797

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A27X-ray2.10A/B41-387[»]
ProteinModelPortaliQ9HCJ6.
SMRiQ9HCJ6. Positions 39-384.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCJ6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294681.
HOVERGENiHBG002466.
InParanoidiQ9HCJ6.
OMAiDSENKER.
OrthoDBiEOG7VQJD4.
PhylomeDBiQ9HCJ6.
TreeFamiTF314255.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HCJ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKEGVEKAE ETEQMIEKEA GKEPAEGGGG DGSHRLGDAQ EMRAVVLAGF
60 70 80 90 100
GGLNKLRLFR KAMPEPQDGE LKIRVKACGL NFIDLMVRQG NIDNPPKTPL
110 120 130 140 150
VPGFECSGIV EALGDSVKGY EIGDRVMAFV NYNAWAEVVC TPVEFVYKIP
160 170 180 190 200
DDMSFSEAAA FPMNFVTAYV MLFEVANLRE GMSVLVHSAG GGVGQAVAQL
210 220 230 240 250
CSTVPNVTVF GTASTFKHEA IKDSVTHLFD RNADYVQEVK RISAEGVDIV
260 270 280 290 300
LDCLCGDNTG KGLSLLKPLG TYILYGSSNM VTGETKSFFS FAKSWWQVEK
310 320 330 340 350
VNPIKLYEEN KVIAGFSLLN LLFKQGRAGL IRGVVEKLIG LYNQKKIKPV
360 370 380 390 400
VDSLWALEEV KEAMQRIHDR GNIGKLILDV EKTPTPLMAN DSTETSEAGE
410
EEEDHEGDSE NKERMPFIQ
Length:419
Mass (Da):45,899
Last modified:September 27, 2004 - v2
Checksum:iBA962924662987AC
GO

Sequence cautioni

The sequence BAB13402.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB046796 mRNA. Translation: BAB13402.1. Different initiation.
BC033537 mRNA. Translation: AAH33537.1.
CCDSiCCDS32492.1.
RefSeqiNP_065978.1. NM_020927.1.
UniGeneiHs.461405.

Genome annotation databases

EnsembliENST00000302536; ENSP00000303129; ENSG00000171724.
GeneIDi57687.
KEGGihsa:57687.
UCSCiuc002ffg.1. human.

Polymorphism databases

DMDMi52783098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB046796 mRNA. Translation: BAB13402.1 . Different initiation.
BC033537 mRNA. Translation: AAH33537.1 .
CCDSi CCDS32492.1.
RefSeqi NP_065978.1. NM_020927.1.
UniGenei Hs.461405.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4A27 X-ray 2.10 A/B 41-387 [» ]
ProteinModelPortali Q9HCJ6.
SMRi Q9HCJ6. Positions 39-384.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121713. 2 interactions.
STRINGi 9606.ENSP00000303129.

PTM databases

PhosphoSitei Q9HCJ6.

Polymorphism databases

DMDMi 52783098.

Proteomic databases

MaxQBi Q9HCJ6.
PaxDbi Q9HCJ6.
PeptideAtlasi Q9HCJ6.
PRIDEi Q9HCJ6.

Protocols and materials databases

DNASUi 57687.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302536 ; ENSP00000303129 ; ENSG00000171724 .
GeneIDi 57687.
KEGGi hsa:57687.
UCSCi uc002ffg.1. human.

Organism-specific databases

CTDi 57687.
GeneCardsi GC16P077822.
HGNCi HGNC:29315. VAT1L.
HPAi CAB046032.
HPA044061.
neXtProti NX_Q9HCJ6.
PharmGKBi PA164727497.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0604.
GeneTreei ENSGT00550000074483.
HOGENOMi HOG000294681.
HOVERGENi HBG002466.
InParanoidi Q9HCJ6.
OMAi DSENKER.
OrthoDBi EOG7VQJD4.
PhylomeDBi Q9HCJ6.
TreeFami TF314255.

Miscellaneous databases

ChiTaRSi VAT1L. human.
EvolutionaryTracei Q9HCJ6.
GenomeRNAii 57687.
NextBioi 64514.
PROi Q9HCJ6.

Gene expression databases

Bgeei Q9HCJ6.
CleanExi HS_VAT1L.
ExpressionAtlasi Q9HCJ6. baseline and differential.
Genevestigatori Q9HCJ6.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
PROSITEi PS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects."
    Dastani Z., Pajukanta P., Marcil M., Rudzicz N., Ruel I., Bailey S.D., Lee J.C., Lemire M., Faith J., Platko J., Rioux J., Hudson T.J., Gaudet D., Engert J.C., Genest J.
    Eur. J. Hum. Genet. 18:342-347(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Crystal structure of human synaptic vesicle membrane protein Vat-1 homolog-like protein."
    Structural genomics consortium (SGC)
    Submitted (SEP-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 41-387.

Entry informationi

Entry nameiVAT1L_HUMAN
AccessioniPrimary (citable) accession number: Q9HCJ6
Secondary accession number(s): Q8IYW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3