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Protein

Synaptic vesicle membrane protein VAT-1 homolog-like

Gene

VAT1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171724-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle membrane protein VAT-1 homolog-like (EC:1.-.-.-)
Gene namesi
Name:VAT1L
Synonyms:KIAA1576
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29315. VAT1L.

Pathology & Biotechi

Organism-specific databases

DisGeNETi57687.
OpenTargetsiENSG00000171724.
PharmGKBiPA164727497.

Polymorphism and mutation databases

BioMutaiVAT1L.
DMDMi52783098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001609221 – 419Synaptic vesicle membrane protein VAT-1 homolog-likeAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei392PhosphoserineBy similarity1
Modified residuei393PhosphothreonineBy similarity1
Modified residuei395PhosphothreonineBy similarity1
Modified residuei396PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HCJ6.
MaxQBiQ9HCJ6.
PaxDbiQ9HCJ6.
PeptideAtlasiQ9HCJ6.
PRIDEiQ9HCJ6.

PTM databases

iPTMnetiQ9HCJ6.
PhosphoSitePlusiQ9HCJ6.

Expressioni

Tissue specificityi

Detected in skin fibroblasts.1 Publication

Gene expression databases

BgeeiENSG00000171724.
CleanExiHS_VAT1L.
GenevisibleiQ9HCJ6. HS.

Organism-specific databases

HPAiCAB046032.
HPA044061.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBXN2BQ14CS03EBI-10234766,EBI-1993619

Protein-protein interaction databases

BioGridi121713. 6 interactors.
IntActiQ9HCJ6. 1 interactor.
STRINGi9606.ENSP00000303129.

Structurei

Secondary structure

1419
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 47Combined sources6
Beta strandi49 – 52Combined sources4
Helixi53 – 55Combined sources3
Beta strandi56 – 61Combined sources6
Beta strandi70 – 80Combined sources11
Helixi82 – 89Combined sources8
Beta strandi92 – 94Combined sources3
Beta strandi98 – 100Combined sources3
Beta strandi104 – 113Combined sources10
Beta strandi125 – 129Combined sources5
Beta strandi135 – 142Combined sources8
Helixi143 – 145Combined sources3
Beta strandi146 – 148Combined sources3
Helixi155 – 159Combined sources5
Helixi162 – 173Combined sources12
Beta strandi183 – 188Combined sources6
Helixi192 – 201Combined sources10
Beta strandi208 – 213Combined sources6
Helixi215 – 217Combined sources3
Helixi218 – 221Combined sources4
Helixi222 – 224Combined sources3
Beta strandi225 – 230Combined sources6
Helixi235 – 242Combined sources8
Beta strandi247 – 253Combined sources7
Beta strandi266 – 275Combined sources10
Helixi303 – 309Combined sources7
Beta strandi312 – 316Combined sources5
Helixi318 – 323Combined sources6
Helixi328 – 343Combined sources16
Beta strandi351 – 355Combined sources5
Helixi357 – 359Combined sources3
Helixi360 – 368Combined sources9
Beta strandi373 – 379Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A27X-ray2.10A/B41-387[»]
ProteinModelPortaliQ9HCJ6.
SMRiQ9HCJ6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCJ6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1198. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294681.
HOVERGENiHBG002466.
InParanoidiQ9HCJ6.
OMAiICFMQAG.
OrthoDBiEOG091G0EEJ.
PhylomeDBiQ9HCJ6.
TreeFamiTF314255.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HCJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEGVEKAE ETEQMIEKEA GKEPAEGGGG DGSHRLGDAQ EMRAVVLAGF
60 70 80 90 100
GGLNKLRLFR KAMPEPQDGE LKIRVKACGL NFIDLMVRQG NIDNPPKTPL
110 120 130 140 150
VPGFECSGIV EALGDSVKGY EIGDRVMAFV NYNAWAEVVC TPVEFVYKIP
160 170 180 190 200
DDMSFSEAAA FPMNFVTAYV MLFEVANLRE GMSVLVHSAG GGVGQAVAQL
210 220 230 240 250
CSTVPNVTVF GTASTFKHEA IKDSVTHLFD RNADYVQEVK RISAEGVDIV
260 270 280 290 300
LDCLCGDNTG KGLSLLKPLG TYILYGSSNM VTGETKSFFS FAKSWWQVEK
310 320 330 340 350
VNPIKLYEEN KVIAGFSLLN LLFKQGRAGL IRGVVEKLIG LYNQKKIKPV
360 370 380 390 400
VDSLWALEEV KEAMQRIHDR GNIGKLILDV EKTPTPLMAN DSTETSEAGE
410
EEEDHEGDSE NKERMPFIQ
Length:419
Mass (Da):45,899
Last modified:September 27, 2004 - v2
Checksum:iBA962924662987AC
GO

Sequence cautioni

The sequence BAB13402 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046796 mRNA. Translation: BAB13402.1. Different initiation.
BC033537 mRNA. Translation: AAH33537.1.
CCDSiCCDS32492.1.
RefSeqiNP_065978.1. NM_020927.2.
UniGeneiHs.461405.

Genome annotation databases

EnsembliENST00000302536; ENSP00000303129; ENSG00000171724.
GeneIDi57687.
KEGGihsa:57687.
UCSCiuc002ffg.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046796 mRNA. Translation: BAB13402.1. Different initiation.
BC033537 mRNA. Translation: AAH33537.1.
CCDSiCCDS32492.1.
RefSeqiNP_065978.1. NM_020927.2.
UniGeneiHs.461405.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A27X-ray2.10A/B41-387[»]
ProteinModelPortaliQ9HCJ6.
SMRiQ9HCJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121713. 6 interactors.
IntActiQ9HCJ6. 1 interactor.
STRINGi9606.ENSP00000303129.

PTM databases

iPTMnetiQ9HCJ6.
PhosphoSitePlusiQ9HCJ6.

Polymorphism and mutation databases

BioMutaiVAT1L.
DMDMi52783098.

Proteomic databases

EPDiQ9HCJ6.
MaxQBiQ9HCJ6.
PaxDbiQ9HCJ6.
PeptideAtlasiQ9HCJ6.
PRIDEiQ9HCJ6.

Protocols and materials databases

DNASUi57687.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302536; ENSP00000303129; ENSG00000171724.
GeneIDi57687.
KEGGihsa:57687.
UCSCiuc002ffg.2. human.

Organism-specific databases

CTDi57687.
DisGeNETi57687.
GeneCardsiVAT1L.
HGNCiHGNC:29315. VAT1L.
HPAiCAB046032.
HPA044061.
neXtProtiNX_Q9HCJ6.
OpenTargetsiENSG00000171724.
PharmGKBiPA164727497.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1198. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294681.
HOVERGENiHBG002466.
InParanoidiQ9HCJ6.
OMAiICFMQAG.
OrthoDBiEOG091G0EEJ.
PhylomeDBiQ9HCJ6.
TreeFamiTF314255.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171724-MONOMER.

Miscellaneous databases

ChiTaRSiVAT1L. human.
EvolutionaryTraceiQ9HCJ6.
GenomeRNAii57687.
PROiQ9HCJ6.

Gene expression databases

BgeeiENSG00000171724.
CleanExiHS_VAT1L.
GenevisibleiQ9HCJ6. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVAT1L_HUMAN
AccessioniPrimary (citable) accession number: Q9HCJ6
Secondary accession number(s): Q8IYW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.