Q9HCJ5 (ZSWM6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger SWIM domain-containing protein 6

Gene names

Name:	ZSWIM6
Synonyms:	KIAA1577

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1215 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SWIM-type zinc finger.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuron projection morphogenesis Inferred from electronic annotation. Source: Compara regulation of neuron migration Inferred from electronic annotation. Source: Compara
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1215	1215	Zinc finger SWIM domain-containing protein 6		PRO_0000223105
Regions
	Zinc finger	246 – 283	38	SWIM-type
	Compositional bias	19 – 154	136	Gly-rich
	Compositional bias	155 – 158	4	Poly-Ser
	Compositional bias	160 – 197	38	Ala-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9HCJ5 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 828B5AA0644EECE0	FASTA	1,215	133,470
	10 20 30 40 50 60 MAERGQQPPP AKRLCCRPGG GGGGGGSSGG GGGAGGGYSS ACRPGPRAGG AAAAAACGGG 70 80 90 100 110 120 AALGLLPPGK TQSPESLLDI AARRVAEKWP FQRVEERFER IPEPVQRRIV YWSFPRSERE 130 140 150 160 170 180 ICMYSSFNTG GGAAGGPGDD SGGGGGAGGG GGGGSSSSPA ATSAAATSAA AAAAAAAAAA 190 200 210 220 230 240 AAAAGAGAPS VGAAGAADGG DETRLPFRRG IALLESGCVD NVLQVGFHLS GTVTEPAIQS 250 260 270 280 290 300 EPETVCNVAI SFDRCKITSV TCSCGNKDIF YCAHVVALSL YRIRKPDQVK LHLPISETLF 310 320 330 340 350 360 QMNRDQLQKF VQYLITVHHT EVLPTAQKLA DEILSQNSEI NQVHGAPDPT AGASIDDENC 370 380 390 400 410 420 WHLDEEQVQE QVKLFLSQGG YHGSGKQLNL LFAKVREMLK MRDSNGARML TLITEQFMAD 430 440 450 460 470 480 PRLSLWRQQG TAMTDKYRQL WDELGALWMC IVLNPHCKLE QKASWLKQLK KWNSVDVCPW 490 500 510 520 530 540 EDGNHGSELP NLTNALPQGA NANQDSSNRP HRTVFTRAIE ACDLHWQDSH LQHIISSDLY 550 560 570 580 590 600 TNYCYHDDTE NSLFDSRGWP LWHEHVPTAC ARVDALRSHG YPREALRLAI AIVNTLRRQQ 610 620 630 640 650 660 QKQLEMFRTQ KKELPHKNIT SITNLEGWVG HPLDPVGTLF SSLMEACRID DENLSGFSDF 670 680 690 700 710 720 TENMGQCKSL EYQHLPAHKF LEEGESYLTL AVEVALIGLG QQRIMPDGLY TQEKVCRNEE 730 740 750 760 770 780 QLISKLQEIE LDDTLVKIFR KQAVFLLEAG PYSGLGEIIH RESVPMHTFA KYLFTSLLPH 790 800 810 820 830 840 DAELAYKIAL RAMRLLVLES TAPSGDLTRP HHIASVVPNR YPRWFTLSHI ESQQCELAST 850 860 870 880 890 900 MLTAAKGDVR RLETVLESIQ KNIHSSSHIF KLAQDAFKIA TLMDSLPDIT LLKVSLELGL 910 920 930 940 950 960 QVMRMTLSTL NWRRREMVRW LVTCATEVGV YALDSIMQTW FTLFTPTEAT SIVATTVMSN 970 980 990 1000 1010 1020 STIVRLHLDC HQQEKLASSA RTLALQCAMK DPQNCALSAL TLCEKDHIAF ETAYQIVLDA 1030 1040 1050 1060 1070 1080 ATTGMSYTQL FTIARYMEHR GYPMRAYKLA TLAMTHLNLS YNQDTHPAIN DVLWACALSH 1090 1100 1110 1120 1130 1140 SLGKNELAAI IPLVVKSVKC ATVLSDILRR CTLTTPGMVG LHGRRNSGKL MSLDKAPLRQ 1150 1160 1170 1180 1190 1200 LLDATIGAYI NTTHSRLTHI SPRHYSEFIE FLSKARETFL MAHDGHIQFT QFIDNLKQIY 1210 KGKKKLMMLV RERFG

References

[1]

"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 473-1215. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC122718 Genomic DNA. No translation available. AC008836 Genomic DNA. No translation available. AB046797 mRNA. Translation: BAB13403.1.
IPI	IPI00787106.
RefSeq	NP_065979.1. NM_020928.1.
UniGene	Hs.650537.
3D structure databases
ProteinModelPortal	Q9HCJ5.
ModBase	Search...
PTM databases
PhosphoSite	Q9HCJ5.
Polymorphism databases
DMDM	229462808.
Proteomic databases
PaxDb	Q9HCJ5.
PRIDE	Q9HCJ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252744; ENSP00000252744; ENSG00000130449.
GeneID	57688.
KEGG	hsa:57688.
UCSC	uc003jsr.3. human.
Organism-specific databases
CTD	57688.
GeneCards	GC05P060628.
H-InvDB	HIX0004892.
HGNC	HGNC:29316. ZSWIM6.
HPA	HPA035938.
neXtProt	NX_Q9HCJ5.
PharmGKB	PA134910181.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG322060.
HOGENOM	HOG000231419.
HOVERGEN	HBG058098.
InParanoid	Q9HCJ5.
OMA	EQKSSWL.
OrthoDB	EOG405S08.
Gene expression databases
Bgee	Q9HCJ5.
CleanEx	HS_ZSWIM6.
Genevestigator	Q9HCJ5.
GermOnline	ENSG00000130449. Homo sapiens.
Family and domain databases
InterPro	IPR007527. Znf_SWIM. [Graphical view]
PROSITE	PS50966. ZF_SWIM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZSWIM6. human.
GenomeRNAi	57688.
NextBio	64517.

Entry information

Entry name

ZSWM6_HUMAN

Accession

Primary (citable) accession number: Q9HCJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	May 5, 2009
Last modified:	April 3, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.