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Q9HCJ5

- ZSWM6_HUMAN

UniProt

Q9HCJ5 - ZSWM6_HUMAN

Protein

Zinc finger SWIM domain-containing protein 6

Gene

ZSWIM6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri246 – 28338SWIM-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. neuron projection morphogenesis Source: Ensembl
    2. regulation of neuron migration Source: Ensembl

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger SWIM domain-containing protein 6
    Gene namesi
    Name:ZSWIM6
    Synonyms:KIAA1577
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:29316. ZSWIM6.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134910181.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12151215Zinc finger SWIM domain-containing protein 6PRO_0000223105Add
    BLAST

    Proteomic databases

    MaxQBiQ9HCJ5.
    PaxDbiQ9HCJ5.
    PRIDEiQ9HCJ5.

    PTM databases

    PhosphoSiteiQ9HCJ5.

    Expressioni

    Gene expression databases

    BgeeiQ9HCJ5.
    CleanExiHS_ZSWIM6.
    GenevestigatoriQ9HCJ5.

    Organism-specific databases

    HPAiHPA035938.

    Interactioni

    Protein-protein interaction databases

    BioGridi121714. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HCJ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi19 – 154136Gly-richAdd
    BLAST
    Compositional biasi155 – 1584Poly-Ser
    Compositional biasi160 – 19738Ala-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri246 – 28338SWIM-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG322060.
    HOGENOMiHOG000231419.
    HOVERGENiHBG058098.
    InParanoidiQ9HCJ5.
    OMAiEQKSSWL.
    OrthoDBiEOG74J970.
    PhylomeDBiQ9HCJ5.
    TreeFamiTF324881.

    Family and domain databases

    InterProiIPR007527. Znf_SWIM.
    [Graphical view]
    PROSITEiPS50966. ZF_SWIM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HCJ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAERGQQPPP AKRLCCRPGG GGGGGGSSGG GGGAGGGYSS ACRPGPRAGG     50
    AAAAAACGGG AALGLLPPGK TQSPESLLDI AARRVAEKWP FQRVEERFER 100
    IPEPVQRRIV YWSFPRSERE ICMYSSFNTG GGAAGGPGDD SGGGGGAGGG 150
    GGGGSSSSPA ATSAAATSAA AAAAAAAAAA AAAAGAGAPS VGAAGAADGG 200
    DETRLPFRRG IALLESGCVD NVLQVGFHLS GTVTEPAIQS EPETVCNVAI 250
    SFDRCKITSV TCSCGNKDIF YCAHVVALSL YRIRKPDQVK LHLPISETLF 300
    QMNRDQLQKF VQYLITVHHT EVLPTAQKLA DEILSQNSEI NQVHGAPDPT 350
    AGASIDDENC WHLDEEQVQE QVKLFLSQGG YHGSGKQLNL LFAKVREMLK 400
    MRDSNGARML TLITEQFMAD PRLSLWRQQG TAMTDKYRQL WDELGALWMC 450
    IVLNPHCKLE QKASWLKQLK KWNSVDVCPW EDGNHGSELP NLTNALPQGA 500
    NANQDSSNRP HRTVFTRAIE ACDLHWQDSH LQHIISSDLY TNYCYHDDTE 550
    NSLFDSRGWP LWHEHVPTAC ARVDALRSHG YPREALRLAI AIVNTLRRQQ 600
    QKQLEMFRTQ KKELPHKNIT SITNLEGWVG HPLDPVGTLF SSLMEACRID 650
    DENLSGFSDF TENMGQCKSL EYQHLPAHKF LEEGESYLTL AVEVALIGLG 700
    QQRIMPDGLY TQEKVCRNEE QLISKLQEIE LDDTLVKIFR KQAVFLLEAG 750
    PYSGLGEIIH RESVPMHTFA KYLFTSLLPH DAELAYKIAL RAMRLLVLES 800
    TAPSGDLTRP HHIASVVPNR YPRWFTLSHI ESQQCELAST MLTAAKGDVR 850
    RLETVLESIQ KNIHSSSHIF KLAQDAFKIA TLMDSLPDIT LLKVSLELGL 900
    QVMRMTLSTL NWRRREMVRW LVTCATEVGV YALDSIMQTW FTLFTPTEAT 950
    SIVATTVMSN STIVRLHLDC HQQEKLASSA RTLALQCAMK DPQNCALSAL 1000
    TLCEKDHIAF ETAYQIVLDA ATTGMSYTQL FTIARYMEHR GYPMRAYKLA 1050
    TLAMTHLNLS YNQDTHPAIN DVLWACALSH SLGKNELAAI IPLVVKSVKC 1100
    ATVLSDILRR CTLTTPGMVG LHGRRNSGKL MSLDKAPLRQ LLDATIGAYI 1150
    NTTHSRLTHI SPRHYSEFIE FLSKARETFL MAHDGHIQFT QFIDNLKQIY 1200
    KGKKKLMMLV RERFG 1215
    Length:1,215
    Mass (Da):133,470
    Last modified:May 5, 2009 - v2
    Checksum:i828B5AA0644EECE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122718 Genomic DNA. No translation available.
    AC008836 Genomic DNA. No translation available.
    AB046797 mRNA. Translation: BAB13403.1.
    CCDSiCCDS47215.1.
    RefSeqiNP_065979.1. NM_020928.1.
    UniGeneiHs.744939.

    Genome annotation databases

    EnsembliENST00000252744; ENSP00000252744; ENSG00000130449.
    GeneIDi57688.
    KEGGihsa:57688.
    UCSCiuc003jsr.3. human.

    Polymorphism databases

    DMDMi229462808.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122718 Genomic DNA. No translation available.
    AC008836 Genomic DNA. No translation available.
    AB046797 mRNA. Translation: BAB13403.1 .
    CCDSi CCDS47215.1.
    RefSeqi NP_065979.1. NM_020928.1.
    UniGenei Hs.744939.

    3D structure databases

    ProteinModelPortali Q9HCJ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121714. 1 interaction.

    PTM databases

    PhosphoSitei Q9HCJ5.

    Polymorphism databases

    DMDMi 229462808.

    Proteomic databases

    MaxQBi Q9HCJ5.
    PaxDbi Q9HCJ5.
    PRIDEi Q9HCJ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252744 ; ENSP00000252744 ; ENSG00000130449 .
    GeneIDi 57688.
    KEGGi hsa:57688.
    UCSCi uc003jsr.3. human.

    Organism-specific databases

    CTDi 57688.
    GeneCardsi GC05P060628.
    H-InvDB HIX0004892.
    HGNCi HGNC:29316. ZSWIM6.
    HPAi HPA035938.
    neXtProti NX_Q9HCJ5.
    PharmGKBi PA134910181.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322060.
    HOGENOMi HOG000231419.
    HOVERGENi HBG058098.
    InParanoidi Q9HCJ5.
    OMAi EQKSSWL.
    OrthoDBi EOG74J970.
    PhylomeDBi Q9HCJ5.
    TreeFami TF324881.

    Miscellaneous databases

    ChiTaRSi ZSWIM6. human.
    GenomeRNAii 57688.
    NextBioi 64517.
    PROi Q9HCJ5.

    Gene expression databases

    Bgeei Q9HCJ5.
    CleanExi HS_ZSWIM6.
    Genevestigatori Q9HCJ5.

    Family and domain databases

    InterProi IPR007527. Znf_SWIM.
    [Graphical view ]
    PROSITEi PS50966. ZF_SWIM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 473-1215.
      Tissue: Brain.

    Entry informationi

    Entry nameiZSWM6_HUMAN
    AccessioniPrimary (citable) accession number: Q9HCJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3