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Protein

Ribonucleoprotein PTB-binding 2

Gene

RAVER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May bind single-stranded nucleic acids.Curated

GO - Molecular functioni

  • nucleic acid binding Source: GO_Central
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoprotein PTB-binding 2
Alternative name(s):
Protein raver-2
Gene namesi
Name:RAVER2
Synonyms:KIAA1579
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25577. RAVER2.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: May shuttle between the nucleus and the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596391.

Polymorphism and mutation databases

BioMutaiRAVER2.
DMDMi67466983.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 691690Ribonucleoprotein PTB-binding 2PRO_0000081490Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9HCJ3.
MaxQBiQ9HCJ3.
PaxDbiQ9HCJ3.
PeptideAtlasiQ9HCJ3.
PRIDEiQ9HCJ3.

PTM databases

iPTMnetiQ9HCJ3.
PhosphoSiteiQ9HCJ3.

Expressioni

Gene expression databases

BgeeiQ9HCJ3.
CleanExiHS_RAVER2.
ExpressionAtlasiQ9HCJ3. baseline and differential.
GenevisibleiQ9HCJ3. HS.

Organism-specific databases

HPAiHPA045785.
HPA054313.

Interactioni

Subunit structurei

Interacts with PTBP1 and RAVER1.By similarity

Protein-protein interaction databases

BioGridi120520. 4 interactions.
IntActiQ9HCJ3. 1 interaction.
STRINGi9606.ENSP00000360112.

Structurei

Secondary structure

1
691
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi71 – 755Combined sources
Helixi82 – 887Combined sources
Beta strandi97 – 1004Combined sources
Helixi101 – 1033Combined sources
Beta strandi105 – 1084Combined sources
Helixi113 – 12311Combined sources
Beta strandi126 – 1283Combined sources
Beta strandi131 – 1377Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WG1NMR-A71-145[»]
ProteinModelPortaliQ9HCJ3.
SMRiQ9HCJ3. Positions 49-324.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCJ3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 14072RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini142 – 22079RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini231 – 30979RRM 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 3231Ala/Gly-richAdd
BLAST

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJ9Q. Eukaryota.
ENOG410XSBX. LUCA.
GeneTreeiENSGT00390000006046.
HOGENOMiHOG000253941.
HOVERGENiHBG059515.
InParanoidiQ9HCJ3.
OMAiCGRAVKP.
OrthoDBiEOG741Z3J.
PhylomeDBiQ9HCJ3.
TreeFamiTF331660.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAGDGGG EGGAGLGSAA GLGPGPGLRG QGPSAEAHEG APDPMPAALH
60 70 80 90 100
PEEVAARLQR MQRELSNRRK ILVKNLPQDS NCQEVHDLLK DYDLKYCYVD
110 120 130 140 150
RNKRTAFVTL LNGEQAQNAI QMFHQYSFRG KDLIVQLQPT DALLCITNVP
160 170 180 190 200
ISFTSEEFEE LVRAYGNIER CFLVYSEVTG HSKGYGFVEY MKKDFAAKAR
210 220 230 240 250
LELLGRQLGA SALFAQWMDV NLLASELIHS KCLCIDKLPS DYRDSEELLQ
260 270 280 290 300
IFSSVHKPVF CQLAQDEGSY VGGFAVVEYS TAEQAEEVQQ AADGMTIKGS
310 320 330 340 350
KVQVSFCAPG APGRSTLAAL IAAQRVMHSN QKGLLPEPNP VQIMKSLNNP
360 370 380 390 400
AMLQVLLQPQ LCGRAVKPAV LGTPHSLPHL MNPSISPAFL HLNKAHQSSV
410 420 430 440 450
MGNTSNLFLQ NLSHIPLAQQ QLMKFENIHT NNKPGLLGEP PAVVLQTALG
460 470 480 490 500
IGSVLPLKKE LGHHHGEAHK TSSLIPTQTT ITAGMGMLPF FPNQHIAGQA
510 520 530 540 550
GPGHSNTQEK QPATVGMAEG NFSGSQPYLQ SFPNLAAGSL LVGHHKQQQS
560 570 580 590 600
QPKGTEISSG AASKNQTSLL GEPPKEIRLS KNPYLNLASV LPSVCLSSPA
610 620 630 640 650
SKTTLHKTGI ASSILDAISQ GSESQHALEK CIAYSPPFGD YAQVSSLRNE
660 670 680 690
KRGSSYLISA PEGGSVECVD QHSQGTGAYY METYLKKKRV Y
Length:691
Mass (Da):74,339
Last modified:May 10, 2005 - v2
Checksum:i03E287BAF9EE10F8
GO
Isoform 2 (identifier: Q9HCJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     397-409: Missing.

Show »
Length:678
Mass (Da):72,959
Checksum:i9E91312CD90DD981
GO

Sequence cautioni

The sequence BAB13405.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei397 – 40913Missing in isoform 2. 1 PublicationVSP_013676Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046799 mRNA. Translation: BAB13405.1. Different initiation.
BC065303 mRNA. Translation: AAH65303.1.
AL359613 mRNA. Translation: CAB94883.1.
CCDSiCCDS41345.1. [Q9HCJ3-2]
PIRiT50631.
RefSeqiNP_060681.2. NM_018211.3. [Q9HCJ3-2]
XP_006710801.2. XM_006710738.2. [Q9HCJ3-1]
UniGeneiHs.591443.

Genome annotation databases

EnsembliENST00000294428; ENSP00000294428; ENSG00000162437. [Q9HCJ3-1]
ENST00000371072; ENSP00000360112; ENSG00000162437. [Q9HCJ3-2]
GeneIDi55225.
KEGGihsa:55225.
UCSCiuc001dbs.3. human. [Q9HCJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046799 mRNA. Translation: BAB13405.1. Different initiation.
BC065303 mRNA. Translation: AAH65303.1.
AL359613 mRNA. Translation: CAB94883.1.
CCDSiCCDS41345.1. [Q9HCJ3-2]
PIRiT50631.
RefSeqiNP_060681.2. NM_018211.3. [Q9HCJ3-2]
XP_006710801.2. XM_006710738.2. [Q9HCJ3-1]
UniGeneiHs.591443.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WG1NMR-A71-145[»]
ProteinModelPortaliQ9HCJ3.
SMRiQ9HCJ3. Positions 49-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120520. 4 interactions.
IntActiQ9HCJ3. 1 interaction.
STRINGi9606.ENSP00000360112.

PTM databases

iPTMnetiQ9HCJ3.
PhosphoSiteiQ9HCJ3.

Polymorphism and mutation databases

BioMutaiRAVER2.
DMDMi67466983.

Proteomic databases

EPDiQ9HCJ3.
MaxQBiQ9HCJ3.
PaxDbiQ9HCJ3.
PeptideAtlasiQ9HCJ3.
PRIDEiQ9HCJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294428; ENSP00000294428; ENSG00000162437. [Q9HCJ3-1]
ENST00000371072; ENSP00000360112; ENSG00000162437. [Q9HCJ3-2]
GeneIDi55225.
KEGGihsa:55225.
UCSCiuc001dbs.3. human. [Q9HCJ3-1]

Organism-specific databases

CTDi55225.
GeneCardsiRAVER2.
HGNCiHGNC:25577. RAVER2.
HPAiHPA045785.
HPA054313.
MIMi609953. gene.
neXtProtiNX_Q9HCJ3.
PharmGKBiPA144596391.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ9Q. Eukaryota.
ENOG410XSBX. LUCA.
GeneTreeiENSGT00390000006046.
HOGENOMiHOG000253941.
HOVERGENiHBG059515.
InParanoidiQ9HCJ3.
OMAiCGRAVKP.
OrthoDBiEOG741Z3J.
PhylomeDBiQ9HCJ3.
TreeFamiTF331660.

Miscellaneous databases

ChiTaRSiRAVER2. human.
EvolutionaryTraceiQ9HCJ3.
GenomeRNAii55225.
PROiQ9HCJ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HCJ3.
CleanExiHS_RAVER2.
ExpressionAtlasiQ9HCJ3. baseline and differential.
GenevisibleiQ9HCJ3. HS.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 178-691 (ISOFORM 1).
    Tissue: Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 453-691.
    Tissue: Melanoma.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Solution structure of RNA binding domain in BAB13405."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 71-145.

Entry informationi

Entry nameiRAVR2_HUMAN
AccessioniPrimary (citable) accession number: Q9HCJ3
Secondary accession number(s): Q6P141, Q9NPV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: July 6, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.