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Protein

Melanoma-associated antigen E1

Gene

MAGEE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.1 Publication

Keywords - Molecular functioni

Tumor antigen

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen E1
Alternative name(s):
Alpha-dystrobrevin-associated MAGE Protein
Short name:
DAMAGE
Hepatocellular carcinoma-associated protein 1
MAGE-E1 antigen
Gene namesi
Name:MAGEE1
Synonyms:HCA1, KIAA1587
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:24934. MAGEE1.

Subcellular locationi

  • Cytoplasmperinuclear region By similarity
  • Nucleus By similarity
  • Cell membrane By similarity

  • Note: In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane (By similarity).By similarity

GO - Cellular componenti

  • dendrite Source: UniProtKB
  • dystrophin-associated glycoprotein complex Source: Ensembl
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • postsynaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57692.
OpenTargetsiENSG00000198934.
PharmGKBiPA164741999.

Polymorphism and mutation databases

BioMutaiMAGEE1.
DMDMi50428953.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567291 – 957Melanoma-associated antigen E1Add BLAST957

Proteomic databases

EPDiQ9HCI5.
PaxDbiQ9HCI5.
PeptideAtlasiQ9HCI5.
PRIDEiQ9HCI5.

PTM databases

iPTMnetiQ9HCI5.
PhosphoSitePlusiQ9HCI5.

Expressioni

Gene expression databases

BgeeiENSG00000198934.
CleanExiHS_MAGEE1.
GenevisibleiQ9HCI5. HS.

Organism-specific databases

HPAiHPA003047.

Interactioni

Subunit structurei

Interacts with DTNA (By similarity). Interacts with TRIM28.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM28Q132632EBI-949966,EBI-78139

Protein-protein interaction databases

BioGridi121718. 14 interactors.
IntActiQ9HCI5. 4 interactors.
STRINGi9606.ENSP00000354912.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H5Tmodel-A678-897[»]
ProteinModelPortaliQ9HCI5.
SMRiQ9HCI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini491 – 690MAGE 1PROSITE-ProRule annotationAdd BLAST200
Domaini745 – 936MAGE 2PROSITE-ProRule annotationAdd BLAST192

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni743 – 957Interaction with DTNABy similarityAdd BLAST215

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 14Poly-Arg6
Compositional biasi141 – 412Pro-richAdd BLAST272

Sequence similaritiesi

Contains 2 MAGE domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000113461.
HOVERGENiHBG052398.
InParanoidiQ9HCI5.
OMAiEYRNQFP.
OrthoDBiEOG091G0TJ0.
PhylomeDBiQ9HCI5.
TreeFamiTF328505.

Family and domain databases

InterProiIPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 2 hits.
[Graphical view]
PROSITEiPS50838. MAGE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HCI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVSQNSRR RRRRVAKATA HNSSWGEMQA PNAPGLPADV PGSDVPQGPS
60 70 80 90 100
DSQILQGLCA SEGPSTSVLP TSAEGPSTFV PPTISEASSA SGQPTISEGP
110 120 130 140 150
GTSVLPTPSE GLSTSGPPTI SKGLCTSVTL AASEGRNTSR PPTSSEEPST
160 170 180 190 200
SVPPTASEVP STSLPPTPGE GTSTSVPPTA YEGPSTSVVP TPDEGPSTSV
210 220 230 240 250
LPTPGEGPGT SVPLAATEGL STSVQATPDE GPSTSVPPTA TEGLSTPVPP
260 270 280 290 300
TRDEGPSTSV PATPGEGPST SVLPAASDGQ SISLVPTRGK GSSTSVPPTA
310 320 330 340 350
TEGLSTSVQP TAGEGSSTSV PPTPGGGLST SVPPTATEEL STSVPPTPGE
360 370 380 390 400
GPSTSVLPIP GEGLSTSVPP TASDGSDTSV PPTPGEGAST LVQPTAPDGP
410 420 430 440 450
GSSVLPNPGE GPSTLFSSSA SVDRNPSKCS LVLPSPRVTK ASVDSDSEGP
460 470 480 490 500
KGAEGPIEFE VLRDCESPNS ISIMGLNTSR VAITLKPQDP MEQNVAELLQ
510 520 530 540 550
FLLVKDQSKY PIRESEMREY IVKEYRNQFP EILRRAAAHL ECIFRFELRE
560 570 580 590 600
LDPEAHTYIL LNKLGPVPFE GLEESPNGPK MGLLMMILGQ IFLNGNQAKE
610 620 630 640 650
AEIWEMLWRM GVQRERRLSI FGNPKRLLSV EFVWQRYLDY RPVTDCKPVE
660 670 680 690 700
YEFFWGPRSH LETTKMKILK FMAKIYNKDP MDWPEKYNEA LEEDAARAFA
710 720 730 740 750
EGWQALPHFR RPFFEEAAAE VPSPDSEVSS YSSKYAPHSW PESRLESKAR
760 770 780 790 800
KLVQLFLLMD STKLPIPKKG ILYYIGRECS KVFPDLLNRA ARTLNHVYGT
810 820 830 840 850
ELVVLDPRNH SYTLYNRREM EETEEIVDSP NRPGNNFLMQ VLSFIFIMGN
860 870 880 890 900
HARESAVWAF LRGLGVQAGR KHVITCRYLS QRYIDSLRVP DSDPVQYEFV
910 920 930 940 950
WGPRARLETS KMKALRYVAR IHRKEPQDWP QQYREAMEDE ANRADVGHRQ

IFVHNFR
Length:957
Mass (Da):103,254
Last modified:July 19, 2004 - v2
Checksum:iE09F9161384CC2B5
GO

Sequence cautioni

The sequence BAB13413 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076263305S → C.1 PublicationCorresponds to variant rs142080557dbSNPEnsembl.1
Natural variantiVAR_060071339E → D.1 PublicationCorresponds to variant rs7051260dbSNPEnsembl.1
Natural variantiVAR_036585640Y → F in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036586664T → N in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490507 mRNA. Translation: AAM08354.1.
AB046807 mRNA. Translation: BAB13413.1. Different initiation.
AK291270 mRNA. Translation: BAF83959.1.
AL096827 Genomic DNA. Translation: CAI42970.1.
CH471104 Genomic DNA. Translation: EAW98620.1.
BC050588 mRNA. Translation: AAH50588.1.
AF320909 mRNA. Translation: AAG38605.1.
CCDSiCCDS14433.1.
RefSeqiNP_065983.1. NM_020932.2.
UniGeneiHs.8453.

Genome annotation databases

EnsembliENST00000361470; ENSP00000354912; ENSG00000198934.
GeneIDi57692.
KEGGihsa:57692.
UCSCiuc004ecm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490507 mRNA. Translation: AAM08354.1.
AB046807 mRNA. Translation: BAB13413.1. Different initiation.
AK291270 mRNA. Translation: BAF83959.1.
AL096827 Genomic DNA. Translation: CAI42970.1.
CH471104 Genomic DNA. Translation: EAW98620.1.
BC050588 mRNA. Translation: AAH50588.1.
AF320909 mRNA. Translation: AAG38605.1.
CCDSiCCDS14433.1.
RefSeqiNP_065983.1. NM_020932.2.
UniGeneiHs.8453.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H5Tmodel-A678-897[»]
ProteinModelPortaliQ9HCI5.
SMRiQ9HCI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121718. 14 interactors.
IntActiQ9HCI5. 4 interactors.
STRINGi9606.ENSP00000354912.

PTM databases

iPTMnetiQ9HCI5.
PhosphoSitePlusiQ9HCI5.

Polymorphism and mutation databases

BioMutaiMAGEE1.
DMDMi50428953.

Proteomic databases

EPDiQ9HCI5.
PaxDbiQ9HCI5.
PeptideAtlasiQ9HCI5.
PRIDEiQ9HCI5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361470; ENSP00000354912; ENSG00000198934.
GeneIDi57692.
KEGGihsa:57692.
UCSCiuc004ecm.3. human.

Organism-specific databases

CTDi57692.
DisGeNETi57692.
GeneCardsiMAGEE1.
HGNCiHGNC:24934. MAGEE1.
HPAiHPA003047.
MIMi300759. gene.
neXtProtiNX_Q9HCI5.
OpenTargetsiENSG00000198934.
PharmGKBiPA164741999.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000113461.
HOVERGENiHBG052398.
InParanoidiQ9HCI5.
OMAiEYRNQFP.
OrthoDBiEOG091G0TJ0.
PhylomeDBiQ9HCI5.
TreeFamiTF328505.

Miscellaneous databases

GenomeRNAii57692.
PROiQ9HCI5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198934.
CleanExiHS_MAGEE1.
GenevisibleiQ9HCI5. HS.

Family and domain databases

InterProiIPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 2 hits.
[Graphical view]
PROSITEiPS50838. MAGE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGE1_HUMAN
AccessioniPrimary (citable) accession number: Q9HCI5
Secondary accession number(s): Q5JXC7
, Q86TG0, Q8TD92, Q9H216
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.