Melanoma-associated antigen E1 - Homo sapiens (Human)

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Q9HCI5 (MAGE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Melanoma-associated antigen E1

Alternative name(s):
Alpha-dystrobrevin-associated MAGE Protein
Short name=DAMAGE
Hepatocellular carcinoma-associated protein 1
MAGE-E1 antigen

Gene names

Name:	MAGEE1
Synonyms:	HCA1, KIAA1587

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	957 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Interacts with DTNA By similarity.
Subcellular location	Cytoplasm › perinuclear region By similarity. Nucleus By similarity. Cell membrane By similarity. Note: In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, co-localizes with DTNA in the Schwann cell membrane By similarity.
Sequence similarities	Contains 2 MAGE domains.
Sequence caution	The sequence BAB13413.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat
Molecular function	Tumor antigen
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	dendrite Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB perinuclear region of cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB postsynaptic membrane Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 957

957

Melanoma-associated antigen E1

PRO_0000156729

Regions

Domain

491 – 690

200

MAGE 1

Domain

745 – 936

192

MAGE 2

Region

743 – 957

215

Interaction with DTNA By similarity

Compositional bias

9 – 14

Poly-Arg

Compositional bias

141 – 412

272

Pro-rich

Natural variations

Natural variant

339

E → D. Ref.3
Corresponds to variant rs7051260 [ dbSNP | Ensembl ].

VAR_060071

Natural variant

640

Y → F in a breast cancer sample; somatic mutation. Ref.5

VAR_036585

Natural variant

664

T → N in a breast cancer sample; somatic mutation. Ref.5

VAR_036586

Sequences

Sequence

Length

Mass (Da)

Tools

Q9HCI5 [UniParc].

Last modified July 19, 2004. Version 2.
Checksum: E09F9161384CC2B5
Show »

FASTA

957

103,254

        10         20         30         40         50         60 
MSLVSQNSRR RRRRVAKATA HNSSWGEMQA PNAPGLPADV PGSDVPQGPS DSQILQGLCA 

        70         80         90        100        110        120 
SEGPSTSVLP TSAEGPSTFV PPTISEASSA SGQPTISEGP GTSVLPTPSE GLSTSGPPTI 

       130        140        150        160        170        180 
SKGLCTSVTL AASEGRNTSR PPTSSEEPST SVPPTASEVP STSLPPTPGE GTSTSVPPTA 

       190        200        210        220        230        240 
YEGPSTSVVP TPDEGPSTSV LPTPGEGPGT SVPLAATEGL STSVQATPDE GPSTSVPPTA 

       250        260        270        280        290        300 
TEGLSTPVPP TRDEGPSTSV PATPGEGPST SVLPAASDGQ SISLVPTRGK GSSTSVPPTA 

       310        320        330        340        350        360 
TEGLSTSVQP TAGEGSSTSV PPTPGGGLST SVPPTATEEL STSVPPTPGE GPSTSVLPIP 

       370        380        390        400        410        420 
GEGLSTSVPP TASDGSDTSV PPTPGEGAST LVQPTAPDGP GSSVLPNPGE GPSTLFSSSA 

       430        440        450        460        470        480 
SVDRNPSKCS LVLPSPRVTK ASVDSDSEGP KGAEGPIEFE VLRDCESPNS ISIMGLNTSR 

       490        500        510        520        530        540 
VAITLKPQDP MEQNVAELLQ FLLVKDQSKY PIRESEMREY IVKEYRNQFP EILRRAAAHL 

       550        560        570        580        590        600 
ECIFRFELRE LDPEAHTYIL LNKLGPVPFE GLEESPNGPK MGLLMMILGQ IFLNGNQAKE 

       610        620        630        640        650        660 
AEIWEMLWRM GVQRERRLSI FGNPKRLLSV EFVWQRYLDY RPVTDCKPVE YEFFWGPRSH 

       670        680        690        700        710        720 
LETTKMKILK FMAKIYNKDP MDWPEKYNEA LEEDAARAFA EGWQALPHFR RPFFEEAAAE 

       730        740        750        760        770        780 
VPSPDSEVSS YSSKYAPHSW PESRLESKAR KLVQLFLLMD STKLPIPKKG ILYYIGRECS 

       790        800        810        820        830        840 
KVFPDLLNRA ARTLNHVYGT ELVVLDPRNH SYTLYNRREM EETEEIVDSP NRPGNNFLMQ 

       850        860        870        880        890        900 
VLSFIFIMGN HARESAVWAF LRGLGVQAGR KHVITCRYLS QRYIDSLRVP DSDPVQYEFV 

       910        920        930        940        950 
WGPRARLETS KMKALRYVAR IHRKEPQDWP QQYREAMEDE ANRADVGHRQ IFVHNFR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of genes in the chromosome X that are differentially expressed in hepatocellular carcinoma." Dong X.-Y., Chen W.-F. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed: 10997877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-339. Tissue: PNS.
[4]	"Identification of new genes of the MAGE family." Lucas S., Boon T. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 548-664. Tissue: Testis.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-640 AND ASN-664.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF490507 mRNA. Translation: AAM08354.1.
AB046807 mRNA. Translation: BAB13413.1. Different initiation.
BC050588 mRNA. Translation: AAH50588.1.
AF320909 mRNA. Translation: AAG38605.1.

IPI

IPI00015306.

RefSeq

NP_065983.1. NM_020932.2.

UniGene

Hs.8453.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2H5T	model	-	A	678-897	[»]

ProteinModelPortal

Q9HCI5.

SMR

Q9HCI5. Positions 486-699, 740-945.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9HCI5. 2 interactions.

STRING

Q9HCI5.

Polymorphism databases

DMDM

50428953.

Proteomic databases

PRIDE

Q9HCI5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000361470; ENSP00000354912; ENSG00000198934.

GeneID

57692.

KEGG

hsa:57692.

UCSC

uc004ecm.1. human.

Organism-specific databases

CTD

57692.

GeneCards

GC0XP075564.

H-InvDB

HIX0016885.

HGNC

HGNC:24934. MAGEE1.

HPA

HPA003047.

MIM

300759. gene.

neXtProt

NX_Q9HCI5.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

GeneTree

ENSGT00560000076930.

HOGENOM

HBG127422.

HOVERGEN

HBG052398.

InParanoid

Q9HCI5.

OMA

WPESRLE.

OrthoDB

EOG4TF0JJ.

Gene expression databases

ArrayExpress

Q9HCI5.

Bgee

Q9HCI5.

CleanEx

HS_MAGEE1.

Genevestigator

Q9HCI5.

GermOnline

ENSG00000198934. Homo sapiens.

Family and domain databases

InterPro

IPR002190. MAGE.
[Graphical view]

PANTHER

PTHR11736. MAGE. 1 hit.

Pfam

PF01454. MAGE. 2 hits.
[Graphical view]

PROSITE

PS50838. MAGE. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

64535.

SOURCE

Search...

Entry information

Entry name

MAGE1_HUMAN

Accession

Primary (citable) accession number: Q9HCI5
Secondary accession number(s): Q86TG0, Q8TD92, Q9H216

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.