Q9HCH5 (SYTL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptotagmin-like protein 2

Alternative name(s):
Breast cancer-associated antigen SGA-72M
Exophilin-4

Gene names

Name:	SYTL2
Synonyms:	KIAA1597, SGA72M, SLP2, SLP2A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	934 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca2+ while binding to PIP2 is Ca2+ insensitive. Ref.1 Ref.9 Ref.10
Subunit structure	Monomer. Binds NRXN1. Interacts with RAB27B By similarity. Binds RAB27A that has been activated by GTP-binding. Ref.1 Ref.11
Subcellular location	Isoform 1: Cytoplasm. Cell membrane. Note: Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A. Ref.1 Ref.9 Ref.10 Isoform 4: Cell membrane. Note: In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery. Ref.1 Ref.9 Ref.10
Tissue specificity	Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells. Ref.1 Ref.9 Ref.10
Domain	The RabBD domain mediates interaction with RAB27A and recruitment on to vesicular structures in cytotoxic T-lymphocytes (CTL). Ref.1 Ref.9 The C2 1 domain mediates binding to phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and localization to the cell membrane. Ref.1 Ref.9
Post-translational modification	Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A.
Sequence similarities	Contains 2 C2 domains. Contains 1 RabBD (Rab-binding) domain.
Sequence caution	The sequence AAR25619.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAA90989.1 differs from that shown. Reason: Probable cloning artifact. The sequence BAB13423.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB13423.1 differs from that shown. Reason: Frameshift at position 13. The sequence BAB13423.1 differs from that shown. Reason: Sequencing errors. The sequence BAD18516.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Exocytosis
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular protein transport Inferred from electronic annotation. Source: InterPro negative regulation of phosphatase activity Inferred from direct assay. Source: UniProtKB vesicle docking involved in exocytosis Inferred from direct assay Ref.1. Source: UniProtKB
Cellular component	Golgi apparatus Inferred from direct assay. Source: HPA exocytic vesicle Inferred from direct assay Ref.1. Source: UniProtKB extrinsic to plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB melanosome Inferred from sequence or structural similarity. Source: UniProtKB membrane fraction Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from direct assay. Source: HPA
Molecular function	Rab GTPase binding Inferred from electronic annotation. Source: InterPro neurexin family protein binding Inferred from sequence or structural similarity. Source: UniProtKB phosphatase binding Inferred from direct assay. Source: UniProtKB phosphatidylinositol-4,5-bisphosphate binding Inferred from mutant phenotype Ref.9. Source: UniProtKB phosphatidylserine binding Inferred from mutant phenotype Ref.9. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 12 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HCH5-1)

Also known as: Hematopoietic form of Slp2a; Slp2a-hem;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HCH5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-558: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9HCH5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-558: Missing.
     571-610: Missing.

Isoform 4 (identifier: Q9HCH5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     539-539: V → DEKPDQKPVTNECVPRI
     571-610: Missing.

Isoform 5 (identifier: Q9HCH5-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: MIDLSFLTEE...GGSSRDRQQG → MDEPNAEQVY...NAESWRNPSS

Note: No experimental confirmation available.

Isoform 6 (identifier: Q9HCH5-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: MIDLSFLTEE...GGSSRDRQQG → MDEPNAEQVY...NAESWRNPSS
     539-539: V → DEKPDQKPVTNECVPRI

Note: No experimental confirmation available.

Isoform 7 (identifier: Q9HCH5-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-569: Missing.
     570-570: E → M

Note: No experimental confirmation available.

Isoform 8 (identifier: Q9HCH5-11)

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: MIDLSFLTEE...GGSSRDRQQG → MDEPNAEQVY...NAESWRNPSS
     539-539: V → DEKPDQKPVTNECVPRI
     571-610: Missing.

Note: No experimental confirmation available.

Isoform 9 (identifier: Q9HCH5-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1-487: MIDLSFLTEE...GGSSRDRQQG → MLFPQGAHLV...NAESWRNPSS

Note: No experimental confirmation available.

Isoform 10 (identifier: Q9HCH5-13)

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: K → KQ

Note: No experimental confirmation available.

Isoform 11 (identifier: Q9HCH5-14)

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     539-539: V → DEKPDQKPVTNECVPRI

Note: No experimental confirmation available.

Isoform 12 (identifier: Q9HCH5-15)

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.
     571-610: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 934

934

Synaptotagmin-like protein 2

PRO_0000190213

Regions

Domain

1 – 57

57

RabBD

Domain

629 – 733

105

C2 1

Domain

778 – 880

103

C2 2

Compositional bias

579 – 619

41

Ser-rich

Amino acid modifications

Modified residue

262

1

Phosphoserine By similarity

Modified residue

278

1

Phosphoserine By similarity

Modified residue

488

1

Phosphoserine By similarity

Modified residue

562

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 569

569

Missing in isoform 7.

VSP_037896

Alternative sequence

1 – 558

558

Missing in isoform 2 and isoform 3.

VSP_007885

Alternative sequence

1 – 487

487

MIDLS…DRQQG → MDEPNAEQVYNPSQFENLRK FWDLEANSNSKDNDKNITTT SQKNSAPFNRQKHKEFSDIK LSGKNTHEAEVLLSPKKVMA REEMEKLNSKGILQVLPDEI TFPLSPLRKYTYQLPGNESS KENVEKNTEGIVTPVFKEEK DYSEQEIQESIIKTNVLSKD CKDTFNDSLQKLLSETSTPA IQPSGGKVHGKQVLEPSVSE NRTWPQKTDFADTEEEVKGP EKIINEHVDKTVVHPKVKRN SLTASLDKLLKEATGTSPSP LQAKLAPVITGTNSKLEEGR FFGKGIEQSHNTSADKREIL APFPVRDETFGNTALLKKAE SGECQLSTQNLIQMAAEDSH PLDPTSQLSRKGSFGDVASP PQDMLFPQDAHLVPQARVHP SQTEISETVEKVILPPRPVL NDVSAALQKLCGEVWLSYPA GREVGPGEVNPEFPEAVQPV CSPLNPPGVISPWATMDTIV PDRKDFYSSNVVPDKTHEVG SYLAAQMSPSDQTLSSFASI VAQYGKGLPQEVEEIVRETI VQPKSEFLEFSAGLEKLLKE ETETFPSKYESDTGNLSPSK LIGSTEEPRRATSECHPEEL KETVEKAEAPLITESAFDAG FEKLLKEITEAPPYQPQVSV REETHEKESSQSEQTRFLGT VPHFYRAASQTSEMKDKSNG LESQVNQCDKMLGGDALVTD LLVDFCGSRSGVEIPRTPQL YVAHEIGTIKTVTPPEDRDS ESGVAGGQGTLQEPGFGEAS EAISVSRNRQPIPLLMNKEN STKTSKVELTLASPYMKQEK EEEKEGFSESDFSDGNTSSN AESWRNPSS in isoform 5, isoform 6 and isoform 8.

VSP_037900

Alternative sequence

1 – 487

487

MIDLS…DRQQG → MLFPQGAHLVPQARVHPSQM EISETVEKVILPPRPVLNDV SAALQKLCGEVWLSYPAGRE VGPGEVNPEFPEAVQPVCSP LNPPGVISPWATMDTIVPDR KDFYSSNVVPDKTHEVGSYL AAQMSPSDQTLSSFASIVAQ YGKGLPQEVEEIVRETIVQP KSEFLEFSAGLEKLLKEETE TFPSKYESDTGNLSPSKLIG STEEPRRATSECHPEELKET VEKAEAPLITESAFDAGFEK LLKEITEAPPYQPQVSVREE THEKESSQSEQTRFLGTVPH FYRAASQTSEMKDKSNGLES QVNQCDKMLGGDALVTDLLV DFCGSRSGVEIPRTPQLYVA HEIGTIKTVTPPEDRDSESG VAGGQGTLQEPGFGEASEAI SVSRNRQPIPLLMNKENSTK TSKVELTLASPYMKQEKEEE KEGFSESDFSDGNTSSNAES WRNPSS in isoform 9.

VSP_037899

Alternative sequence

1 – 142

142

Missing in isoform 12.

VSP_037901

Alternative sequence

1 – 48

48

Missing in isoform 11.

VSP_037902

Alternative sequence

157

1

K → KQ in isoform 10.

VSP_037904

Alternative sequence

539

1

V → DEKPDQKPVTNECVPRI in isoform 4, isoform 6, isoform 8 and isoform 11.

VSP_037905

Alternative sequence

570

1

E → M in isoform 7.

VSP_037906

Alternative sequence

571 – 610

40

Missing in isoform 3, isoform 4, isoform 8 and isoform 12.

VSP_019004

Experimental info

Mutagenesis

11

1

E → A: Abolishes interaction with RAB27A. Ref.1

Mutagenesis

32

1

R → A: Abolishes interaction with RAB27A. Ref.1

Sequence conflict

603

1

S → P in ABV82746. Ref.1

Sequence conflict

658

1

A → V in BAD18516. Ref.4

Sequence conflict

682

1

K → M in AAI44116. Ref.7

Sequence conflict

718

1

I → V in BAB15030. Ref.4

Sequence conflict

860

1

A → V in BAB13423. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

934

Helix Strand Turn

Details...

Helix

10 – 35

26

Helix

36 – 38

3

Helix

43 – 49

7

Helix

53 – 55

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Hematopoietic form of Slp2a) (Slp2a-hem) [UniParc]. Last modified September 1, 2009. Version 3. Checksum: 4531F9CDD02F25DE	FASTA	934	104,930
	10 20 30 40 50 60 MIDLSFLTEE EQEAIMKVLQ RDAALKRAEE ERVRHLPEKI KDDQQLKNMS GQWFYEAKAK 70 80 90 100 110 120 RHRDKIHGAD IIRASMRKKR PQIAAEQSKD RENGAKESWV NNVNKDAFLP PELAGVVEEP 130 140 150 160 170 180 EEDAAPASPS SSVVNPASSV IDMSQENTRK PNVSPEKRKN PFNSSKLPEG HSSQQTKNEQ 190 200 210 220 230 240 SKNGRTGLFQ TSKEDELSES KEKSTVADTS IQKLEKSKQT LPGLSNGSQI KAPIPKARKM 250 260 270 280 290 300 IYKSTDLNKD DNQSFPRQRT DSLKARGAPR GILKRNSSSS STDSETLRYN HNFEPKSKIV 310 320 330 340 350 360 SPGLTIHERI SEKEHSLEDN SSPNSLEPLK HVRFSAVKDE LPQSPGLIHG REVGEFSVLE 370 380 390 400 410 420 SDRLKNGMED AGDTEEFQSD PKPSQYRKPS LFHQSTSSPY VSKSETHQPM TSGSFPINGL 430 440 450 460 470 480 HSHSEVLTAR PQSMENSPTI NEPKDKSSEL TRLESVLPRS PADELSHCVE PEPSQVPGGS 490 500 510 520 530 540 SRDRQQGSEE EPSPVLKTLE RSAARKMPSK SLEDISSDSS NQAKVDNQPE ELVRSAEDVS 550 560 570 580 590 600 TVPTQPDNPF SHPDKLKRMS KSVPAFLQDE SDDRETDTAS ESSYQLSRHK KSPSSLTNLS 610 620 630 640 650 660 SSSGMTSLSS VSGSVMSVYS GDFGNLEVKG NIQFAIEYVE SLKELHVFVA QCKDLAAADV 670 680 690 700 710 720 KKQRSDPYVK AYLLPDKGKM GKKKTLVVKK TLNPVYNEIL RYKIEKQILK TQKLNLSIWH 730 740 750 760 770 780 RDTFKRNSFL GEVELDLETW DWDNKQNKQL RWYPLKRKTA PVALEAENRG EMKLALQYVP 790 800 810 820 830 840 EPVPGKKLPT TGEVHIWVKE CLDLPLLRGS HLNSFVKCTI LPDTSRKSRQ KTRAVGKTTN 850 860 870 880 890 900 PIFNHTMVYD GFRPEDLMEA CVELTVWDHY KLTNQFLGGL RIGFGTGKSY GTEVDWMDST 910 920 930 SEEVALWEKM VNSPNTWIEA TLPLRMLLIA KISK
	Isoform 2 [UniParc]. Checksum: 8A243E20BAC2ADDF	FASTA	376	42,736
	10 20 30 40 50 60 MSKSVPAFLQ DESDDRETDT ASESSYQLSR HKKSPSSLTN LSSSSGMTSL SSVSGSVMSV 70 80 90 100 110 120 YSGDFGNLEV KGNIQFAIEY VESLKELHVF VAQCKDLAAA DVKKQRSDPY VKAYLLPDKG 130 140 150 160 170 180 KMGKKKTLVV KKTLNPVYNE ILRYKIEKQI LKTQKLNLSI WHRDTFKRNS FLGEVELDLE 190 200 210 220 230 240 TWDWDNKQNK QLRWYPLKRK TAPVALEAEN RGEMKLALQY VPEPVPGKKL PTTGEVHIWV 250 260 270 280 290 300 KECLDLPLLR GSHLNSFVKC TILPDTSRKS RQKTRAVGKT TNPIFNHTMV YDGFRPEDLM 310 320 330 340 350 360 EACVELTVWD HYKLTNQFLG GLRIGFGTGK SYGTEVDWMD STSEEVALWE KMVNSPNTWI 370 EATLPLRMLL IAKISK
	Isoform 3 [UniParc]. Checksum: AF9104112AA3250D	FASTA	336	38,502
	10 20 30 40 50 60 MSKSVPAFLQ DEVSGSVMSV YSGDFGNLEV KGNIQFAIEY VESLKELHVF VAQCKDLAAA 70 80 90 100 110 120 DVKKQRSDPY VKAYLLPDKG KMGKKKTLVV KKTLNPVYNE ILRYKIEKQI LKTQKLNLSI 130 140 150 160 170 180 WHRDTFKRNS FLGEVELDLE TWDWDNKQNK QLRWYPLKRK TAPVALEAEN RGEMKLALQY 190 200 210 220 230 240 VPEPVPGKKL PTTGEVHIWV KECLDLPLLR GSHLNSFVKC TILPDTSRKS RQKTRAVGKT 250 260 270 280 290 300 TNPIFNHTMV YDGFRPEDLM EACVELTVWD HYKLTNQFLG GLRIGFGTGK SYGTEVDWMD 310 320 330 STSEEVALWE KMVNSPNTWI EATLPLRMLL IAKISK
	Isoform 4 [UniParc]. Checksum: 9A2F59AAD94B2463	FASTA	910	102,547
	10 20 30 40 50 60 MIDLSFLTEE EQEAIMKVLQ RDAALKRAEE ERVRHLPEKI KDDQQLKNMS GQWFYEAKAK 70 80 90 100 110 120 RHRDKIHGAD IIRASMRKKR PQIAAEQSKD RENGAKESWV NNVNKDAFLP PELAGVVEEP 130 140 150 160 170 180 EEDAAPASPS SSVVNPASSV IDMSQENTRK PNVSPEKRKN PFNSSKLPEG HSSQQTKNEQ 190 200 210 220 230 240 SKNGRTGLFQ TSKEDELSES KEKSTVADTS IQKLEKSKQT LPGLSNGSQI KAPIPKARKM 250 260 270 280 290 300 IYKSTDLNKD DNQSFPRQRT DSLKARGAPR GILKRNSSSS STDSETLRYN HNFEPKSKIV 310 320 330 340 350 360 SPGLTIHERI SEKEHSLEDN SSPNSLEPLK HVRFSAVKDE LPQSPGLIHG REVGEFSVLE 370 380 390 400 410 420 SDRLKNGMED AGDTEEFQSD PKPSQYRKPS LFHQSTSSPY VSKSETHQPM TSGSFPINGL 430 440 450 460 470 480 HSHSEVLTAR PQSMENSPTI NEPKDKSSEL TRLESVLPRS PADELSHCVE PEPSQVPGGS 490 500 510 520 530 540 SRDRQQGSEE EPSPVLKTLE RSAARKMPSK SLEDISSDSS NQAKVDNQPE ELVRSAEDDE 550 560 570 580 590 600 KPDQKPVTNE CVPRISTVPT QPDNPFSHPD KLKRMSKSVP AFLQDEVSGS VMSVYSGDFG 610 620 630 640 650 660 NLEVKGNIQF AIEYVESLKE LHVFVAQCKD LAAADVKKQR SDPYVKAYLL PDKGKMGKKK 670 680 690 700 710 720 TLVVKKTLNP VYNEILRYKI EKQILKTQKL NLSIWHRDTF KRNSFLGEVE LDLETWDWDN 730 740 750 760 770 780 KQNKQLRWYP LKRKTAPVAL EAENRGEMKL ALQYVPEPVP GKKLPTTGEV HIWVKECLDL 790 800 810 820 830 840 PLLRGSHLNS FVKCTILPDT SRKSRQKTRA VGKTTNPIFN HTMVYDGFRP EDLMEACVEL 850 860 870 880 890 900 TVWDHYKLTN QFLGGLRIGF GTGKSYGTEV DWMDSTSEEV ALWEKMVNSP NTWIEATLPL 910 RMLLIAKISK
	Isoform 5 [UniParc]. Checksum: 6B22ECDEDF3A1785	FASTA	1,256	139,871
	10 20 30 40 50 60 MDEPNAEQVY NPSQFENLRK FWDLEANSNS KDNDKNITTT SQKNSAPFNR QKHKEFSDIK 70 80 90 100 110 120 LSGKNTHEAE VLLSPKKVMA REEMEKLNSK GILQVLPDEI TFPLSPLRKY TYQLPGNESS 130 140 150 160 170 180 KENVEKNTEG IVTPVFKEEK DYSEQEIQES IIKTNVLSKD CKDTFNDSLQ KLLSETSTPA 190 200 210 220 230 240 IQPSGGKVHG KQVLEPSVSE NRTWPQKTDF ADTEEEVKGP EKIINEHVDK TVVHPKVKRN 250 260 270 280 290 300 SLTASLDKLL KEATGTSPSP LQAKLAPVIT GTNSKLEEGR FFGKGIEQSH NTSADKREIL 310 320 330 340 350 360 APFPVRDETF GNTALLKKAE SGECQLSTQN LIQMAAEDSH PLDPTSQLSR KGSFGDVASP 370 380 390 400 410 420 PQDMLFPQDA HLVPQARVHP SQTEISETVE KVILPPRPVL NDVSAALQKL CGEVWLSYPA 430 440 450 460 470 480 GREVGPGEVN PEFPEAVQPV CSPLNPPGVI SPWATMDTIV PDRKDFYSSN VVPDKTHEVG 490 500 510 520 530 540 SYLAAQMSPS DQTLSSFASI VAQYGKGLPQ EVEEIVRETI VQPKSEFLEF SAGLEKLLKE 550 560 570 580 590 600 ETETFPSKYE SDTGNLSPSK LIGSTEEPRR ATSECHPEEL KETVEKAEAP LITESAFDAG 610 620 630 640 650 660 FEKLLKEITE APPYQPQVSV REETHEKESS QSEQTRFLGT VPHFYRAASQ TSEMKDKSNG 670 680 690 700 710 720 LESQVNQCDK MLGGDALVTD LLVDFCGSRS GVEIPRTPQL YVAHEIGTIK TVTPPEDRDS 730 740 750 760 770 780 ESGVAGGQGT LQEPGFGEAS EAISVSRNRQ PIPLLMNKEN STKTSKVELT LASPYMKQEK 790 800 810 820 830 840 EEEKEGFSES DFSDGNTSSN AESWRNPSSS EEEPSPVLKT LERSAARKMP SKSLEDISSD 850 860 870 880 890 900 SSNQAKVDNQ PEELVRSAED VSTVPTQPDN PFSHPDKLKR MSKSVPAFLQ DESDDRETDT 910 920 930 940 950 960 ASESSYQLSR HKKSPSSLTN LSSSSGMTSL SSVSGSVMSV YSGDFGNLEV KGNIQFAIEY 970 980 990 1000 1010 1020 VESLKELHVF VAQCKDLAAA DVKKQRSDPY VKAYLLPDKG KMGKKKTLVV KKTLNPVYNE 1030 1040 1050 1060 1070 1080 ILRYKIEKQI LKTQKLNLSI WHRDTFKRNS FLGEVELDLE TWDWDNKQNK QLRWYPLKRK 1090 1100 1110 1120 1130 1140 TAPVALEAEN RGEMKLALQY VPEPVPGKKL PTTGEVHIWV KECLDLPLLR GSHLNSFVKC 1150 1160 1170 1180 1190 1200 TILPDTSRKS RQKTRAVGKT TNPIFNHTMV YDGFRPEDLM EACVELTVWD HYKLTNQFLG 1210 1220 1230 1240 1250 GLRIGFGTGK SYGTEVDWMD STSEEVALWE KMVNSPNTWI EATLPLRMLL IAKISK
	Isoform 6 [UniParc]. Checksum: D3568DB4C36D95B2	FASTA	1,272	141,722
	10 20 30 40 50 60 MDEPNAEQVY NPSQFENLRK FWDLEANSNS KDNDKNITTT SQKNSAPFNR QKHKEFSDIK 70 80 90 100 110 120 LSGKNTHEAE VLLSPKKVMA REEMEKLNSK GILQVLPDEI TFPLSPLRKY TYQLPGNESS 130 140 150 160 170 180 KENVEKNTEG IVTPVFKEEK DYSEQEIQES IIKTNVLSKD CKDTFNDSLQ KLLSETSTPA 190 200 210 220 230 240 IQPSGGKVHG KQVLEPSVSE NRTWPQKTDF ADTEEEVKGP EKIINEHVDK TVVHPKVKRN 250 260 270 280 290 300 SLTASLDKLL KEATGTSPSP LQAKLAPVIT GTNSKLEEGR FFGKGIEQSH NTSADKREIL 310 320 330 340 350 360 APFPVRDETF GNTALLKKAE SGECQLSTQN LIQMAAEDSH PLDPTSQLSR KGSFGDVASP 370 380 390 400 410 420 PQDMLFPQDA HLVPQARVHP SQTEISETVE KVILPPRPVL NDVSAALQKL CGEVWLSYPA 430 440 450 460 470 480 GREVGPGEVN PEFPEAVQPV CSPLNPPGVI SPWATMDTIV PDRKDFYSSN VVPDKTHEVG 490 500 510 520 530 540 SYLAAQMSPS DQTLSSFASI VAQYGKGLPQ EVEEIVRETI VQPKSEFLEF SAGLEKLLKE 550 560 570 580 590 600 ETETFPSKYE SDTGNLSPSK LIGSTEEPRR ATSECHPEEL KETVEKAEAP LITESAFDAG 610 620 630 640 650 660 FEKLLKEITE APPYQPQVSV REETHEKESS QSEQTRFLGT VPHFYRAASQ TSEMKDKSNG 670 680 690 700 710 720 LESQVNQCDK MLGGDALVTD LLVDFCGSRS GVEIPRTPQL YVAHEIGTIK TVTPPEDRDS 730 740 750 760 770 780 ESGVAGGQGT LQEPGFGEAS EAISVSRNRQ PIPLLMNKEN STKTSKVELT LASPYMKQEK 790 800 810 820 830 840 EEEKEGFSES DFSDGNTSSN AESWRNPSSS EEEPSPVLKT LERSAARKMP SKSLEDISSD 850 860 870 880 890 900 SSNQAKVDNQ PEELVRSAED DEKPDQKPVT NECVPRISTV PTQPDNPFSH PDKLKRMSKS 910 920 930 940 950 960 VPAFLQDESD DRETDTASES SYQLSRHKKS PSSLTNLSSS SGMTSLSSVS GSVMSVYSGD 970 980 990 1000 1010 1020 FGNLEVKGNI QFAIEYVESL KELHVFVAQC KDLAAADVKK QRSDPYVKAY LLPDKGKMGK 1030 1040 1050 1060 1070 1080 KKTLVVKKTL NPVYNEILRY KIEKQILKTQ KLNLSIWHRD TFKRNSFLGE VELDLETWDW 1090 1100 1110 1120 1130 1140 DNKQNKQLRW YPLKRKTAPV ALEAENRGEM KLALQYVPEP VPGKKLPTTG EVHIWVKECL 1150 1160 1170 1180 1190 1200 DLPLLRGSHL NSFVKCTILP DTSRKSRQKT RAVGKTTNPI FNHTMVYDGF RPEDLMEACV 1210 1220 1230 1240 1250 1260 ELTVWDHYKL TNQFLGGLRI GFGTGKSYGT EVDWMDSTSE EVALWEKMVN SPNTWIEATL 1270 PLRMLLIAKI SK
	Isoform 7 [UniParc]. Checksum: 248C5AD2B497C9EE	FASTA	365	41,534
	10 20 30 40 50 60 MSDDRETDTA SESSYQLSRH KKSPSSLTNL SSSSGMTSLS SVSGSVMSVY SGDFGNLEVK 70 80 90 100 110 120 GNIQFAIEYV ESLKELHVFV AQCKDLAAAD VKKQRSDPYV KAYLLPDKGK MGKKKTLVVK 130 140 150 160 170 180 KTLNPVYNEI LRYKIEKQIL KTQKLNLSIW HRDTFKRNSF LGEVELDLET WDWDNKQNKQ 190 200 210 220 230 240 LRWYPLKRKT APVALEAENR GEMKLALQYV PEPVPGKKLP TTGEVHIWVK ECLDLPLLRG 250 260 270 280 290 300 SHLNSFVKCT ILPDTSRKSR QKTRAVGKTT NPIFNHTMVY DGFRPEDLME ACVELTVWDH 310 320 330 340 350 360 YKLTNQFLGG LRIGFGTGKS YGTEVDWMDS TSEEVALWEK MVNSPNTWIE ATLPLRMLLI AKISK
	Isoform 8 [UniParc]. Checksum: 68C8C0CB131F520E	FASTA	1,232	137,488
	10 20 30 40 50 60 MDEPNAEQVY NPSQFENLRK FWDLEANSNS KDNDKNITTT SQKNSAPFNR QKHKEFSDIK 70 80 90 100 110 120 LSGKNTHEAE VLLSPKKVMA REEMEKLNSK GILQVLPDEI TFPLSPLRKY TYQLPGNESS 130 140 150 160 170 180 KENVEKNTEG IVTPVFKEEK DYSEQEIQES IIKTNVLSKD CKDTFNDSLQ KLLSETSTPA 190 200 210 220 230 240 IQPSGGKVHG KQVLEPSVSE NRTWPQKTDF ADTEEEVKGP EKIINEHVDK TVVHPKVKRN 250 260 270 280 290 300 SLTASLDKLL KEATGTSPSP LQAKLAPVIT GTNSKLEEGR FFGKGIEQSH NTSADKREIL 310 320 330 340 350 360 APFPVRDETF GNTALLKKAE SGECQLSTQN LIQMAAEDSH PLDPTSQLSR KGSFGDVASP 370 380 390 400 410 420 PQDMLFPQDA HLVPQARVHP SQTEISETVE KVILPPRPVL NDVSAALQKL CGEVWLSYPA 430 440 450 460 470 480 GREVGPGEVN PEFPEAVQPV CSPLNPPGVI SPWATMDTIV PDRKDFYSSN VVPDKTHEVG 490 500 510 520 530 540 SYLAAQMSPS DQTLSSFASI VAQYGKGLPQ EVEEIVRETI VQPKSEFLEF SAGLEKLLKE 550 560 570 580 590 600 ETETFPSKYE SDTGNLSPSK LIGSTEEPRR ATSECHPEEL KETVEKAEAP LITESAFDAG 610 620 630 640 650 660 FEKLLKEITE APPYQPQVSV REETHEKESS QSEQTRFLGT VPHFYRAASQ TSEMKDKSNG 670 680 690 700 710 720 LESQVNQCDK MLGGDALVTD LLVDFCGSRS GVEIPRTPQL YVAHEIGTIK TVTPPEDRDS 730 740 750 760 770 780 ESGVAGGQGT LQEPGFGEAS EAISVSRNRQ PIPLLMNKEN STKTSKVELT LASPYMKQEK 790 800 810 820 830 840 EEEKEGFSES DFSDGNTSSN AESWRNPSSS EEEPSPVLKT LERSAARKMP SKSLEDISSD 850 860 870 880 890 900 SSNQAKVDNQ PEELVRSAED DEKPDQKPVT NECVPRISTV PTQPDNPFSH PDKLKRMSKS 910 920 930 940 950 960 VPAFLQDEVS GSVMSVYSGD FGNLEVKGNI QFAIEYVESL KELHVFVAQC KDLAAADVKK 970 980 990 1000 1010 1020 QRSDPYVKAY LLPDKGKMGK KKTLVVKKTL NPVYNEILRY KIEKQILKTQ KLNLSIWHRD 1030 1040 1050 1060 1070 1080 TFKRNSFLGE VELDLETWDW DNKQNKQLRW YPLKRKTAPV ALEAENRGEM KLALQYVPEP 1090 1100 1110 1120 1130 1140 VPGKKLPTTG EVHIWVKECL DLPLLRGSHL NSFVKCTILP DTSRKSRQKT RAVGKTTNPI 1150 1160 1170 1180 1190 1200 FNHTMVYDGF RPEDLMEACV ELTVWDHYKL TNQFLGGLRI GFGTGKSYGT EVDWMDSTSE 1210 1220 1230 EVALWEKMVN SPNTWIEATL PLRMLLIAKI SK
	Isoform 9 [UniParc]. Checksum: E53DC303C5C3758C	FASTA	893	99,411
	10 20 30 40 50 60 MLFPQGAHLV PQARVHPSQM EISETVEKVI LPPRPVLNDV SAALQKLCGE VWLSYPAGRE 70 80 90 100 110 120 VGPGEVNPEF PEAVQPVCSP LNPPGVISPW ATMDTIVPDR KDFYSSNVVP DKTHEVGSYL 130 140 150 160 170 180 AAQMSPSDQT LSSFASIVAQ YGKGLPQEVE EIVRETIVQP KSEFLEFSAG LEKLLKEETE 190 200 210 220 230 240 TFPSKYESDT GNLSPSKLIG STEEPRRATS ECHPEELKET VEKAEAPLIT ESAFDAGFEK 250 260 270 280 290 300 LLKEITEAPP YQPQVSVREE THEKESSQSE QTRFLGTVPH FYRAASQTSE MKDKSNGLES 310 320 330 340 350 360 QVNQCDKMLG GDALVTDLLV DFCGSRSGVE IPRTPQLYVA HEIGTIKTVT PPEDRDSESG 370 380 390 400 410 420 VAGGQGTLQE PGFGEASEAI SVSRNRQPIP LLMNKENSTK TSKVELTLAS PYMKQEKEEE 430 440 450 460 470 480 KEGFSESDFS DGNTSSNAES WRNPSSSEEE PSPVLKTLER SAARKMPSKS LEDISSDSSN 490 500 510 520 530 540 QAKVDNQPEE LVRSAEDVST VPTQPDNPFS HPDKLKRMSK SVPAFLQDES DDRETDTASE 550 560 570 580 590 600 SSYQLSRHKK SPSSLTNLSS SSGMTSLSSV SGSVMSVYSG DFGNLEVKGN IQFAIEYVES 610 620 630 640 650 660 LKELHVFVAQ CKDLAAADVK KQRSDPYVKA YLLPDKGKMG KKKTLVVKKT LNPVYNEILR 670 680 690 700 710 720 YKIEKQILKT QKLNLSIWHR DTFKRNSFLG EVELDLETWD WDNKQNKQLR WYPLKRKTAP 730 740 750 760 770 780 VALEAENRGE MKLALQYVPE PVPGKKLPTT GEVHIWVKEC LDLPLLRGSH LNSFVKCTIL 790 800 810 820 830 840 PDTSRKSRQK TRAVGKTTNP IFNHTMVYDG FRPEDLMEAC VELTVWDHYK LTNQFLGGLR 850 860 870 880 890 IGFGTGKSYG TEVDWMDSTS EEVALWEKMV NSPNTWIEAT LPLRMLLIAK ISK
	Isoform 10 [UniParc]. Checksum: 56E05093B491746B	FASTA	935	105,058
	10 20 30 40 50 60 MIDLSFLTEE EQEAIMKVLQ RDAALKRAEE ERVRHLPEKI KDDQQLKNMS GQWFYEAKAK 70 80 90 100 110 120 RHRDKIHGAD IIRASMRKKR PQIAAEQSKD RENGAKESWV NNVNKDAFLP PELAGVVEEP 130 140 150 160 170 180 EEDAAPASPS SSVVNPASSV IDMSQENTRK PNVSPEKQRK NPFNSSKLPE GHSSQQTKNE 190 200 210 220 230 240 QSKNGRTGLF QTSKEDELSE SKEKSTVADT SIQKLEKSKQ TLPGLSNGSQ IKAPIPKARK 250 260 270 280 290 300 MIYKSTDLNK DDNQSFPRQR TDSLKARGAP RGILKRNSSS SSTDSETLRY NHNFEPKSKI 310 320 330 340 350 360 VSPGLTIHER ISEKEHSLED NSSPNSLEPL KHVRFSAVKD ELPQSPGLIH GREVGEFSVL 370 380 390 400 410 420 ESDRLKNGME DAGDTEEFQS DPKPSQYRKP SLFHQSTSSP YVSKSETHQP MTSGSFPING 430 440 450 460 470 480 LHSHSEVLTA RPQSMENSPT INEPKDKSSE LTRLESVLPR SPADELSHCV EPEPSQVPGG 490 500 510 520 530 540 SSRDRQQGSE EEPSPVLKTL ERSAARKMPS KSLEDISSDS SNQAKVDNQP EELVRSAEDV 550 560 570 580 590 600 STVPTQPDNP FSHPDKLKRM SKSVPAFLQD ESDDRETDTA SESSYQLSRH KKSPSSLTNL 610 620 630 640 650 660 SSSSGMTSLS SVSGSVMSVY SGDFGNLEVK GNIQFAIEYV ESLKELHVFV AQCKDLAAAD 670 680 690 700 710 720 VKKQRSDPYV KAYLLPDKGK MGKKKTLVVK KTLNPVYNEI LRYKIEKQIL KTQKLNLSIW 730 740 750 760 770 780 HRDTFKRNSF LGEVELDLET WDWDNKQNKQ LRWYPLKRKT APVALEAENR GEMKLALQYV 790 800 810 820 830 840 PEPVPGKKLP TTGEVHIWVK ECLDLPLLRG SHLNSFVKCT ILPDTSRKSR QKTRAVGKTT 850 860 870 880 890 900 NPIFNHTMVY DGFRPEDLME ACVELTVWDH YKLTNQFLGG LRIGFGTGKS YGTEVDWMDS 910 920 930 TSEEVALWEK MVNSPNTWIE ATLPLRMLLI AKISK
	Isoform 11 [UniParc]. Checksum: BDDC40D39014A87A	FASTA	902	101,062
	10 20 30 40 50 60 MSGQWFYEAK AKRHRDKIHG ADIIRASMRK KRPQIAAEQS KDRENGAKES WVNNVNKDAF 70 80 90 100 110 120 LPPELAGVVE EPEEDAAPAS PSSSVVNPAS SVIDMSQENT RKPNVSPEKR KNPFNSSKLP 130 140 150 160 170 180 EGHSSQQTKN EQSKNGRTGL FQTSKEDELS ESKEKSTVAD TSIQKLEKSK QTLPGLSNGS 190 200 210 220 230 240 QIKAPIPKAR KMIYKSTDLN KDDNQSFPRQ RTDSLKARGA PRGILKRNSS SSSTDSETLR 250 260 270 280 290 300 YNHNFEPKSK IVSPGLTIHE RISEKEHSLE DNSSPNSLEP LKHVRFSAVK DELPQSPGLI 310 320 330 340 350 360 HGREVGEFSV LESDRLKNGM EDAGDTEEFQ SDPKPSQYRK PSLFHQSTSS PYVSKSETHQ 370 380 390 400 410 420 PMTSGSFPIN GLHSHSEVLT ARPQSMENSP TINEPKDKSS ELTRLESVLP RSPADELSHC 430 440 450 460 470 480 VEPEPSQVPG GSSRDRQQGS EEEPSPVLKT LERSAARKMP SKSLEDISSD SSNQAKVDNQ 490 500 510 520 530 540 PEELVRSAED DEKPDQKPVT NECVPRISTV PTQPDNPFSH PDKLKRMSKS VPAFLQDESD 550 560 570 580 590 600 DRETDTASES SYQLSRHKKS PSSLTNLSSS SGMTSLSSVS GSVMSVYSGD FGNLEVKGNI 610 620 630 640 650 660 QFAIEYVESL KELHVFVAQC KDLAAADVKK QRSDPYVKAY LLPDKGKMGK KKTLVVKKTL 670 680 690 700 710 720 NPVYNEILRY KIEKQILKTQ KLNLSIWHRD TFKRNSFLGE VELDLETWDW DNKQNKQLRW 730 740 750 760 770 780 YPLKRKTAPV ALEAENRGEM KLALQYVPEP VPGKKLPTTG EVHIWVKECL DLPLLRGSHL 790 800 810 820 830 840 NSFVKCTILP DTSRKSRQKT RAVGKTTNPI FNHTMVYDGF RPEDLMEACV ELTVWDHYKL 850 860 870 880 890 900 TNQFLGGLRI GFGTGKSYGT EVDWMDSTSE EVALWEKMVN SPNTWIEATL PLRMLLIAKI SK
	Isoform 12 [UniParc]. Checksum: B224984F9D70523F	FASTA	752	84,651
	10 20 30 40 50 60 MSQENTRKPN VSPEKRKNPF NSSKLPEGHS SQQTKNEQSK NGRTGLFQTS KEDELSESKE 70 80 90 100 110 120 KSTVADTSIQ KLEKSKQTLP GLSNGSQIKA PIPKARKMIY KSTDLNKDDN QSFPRQRTDS 130 140 150 160 170 180 LKARGAPRGI LKRNSSSSST DSETLRYNHN FEPKSKIVSP GLTIHERISE KEHSLEDNSS 190 200 210 220 230 240 PNSLEPLKHV RFSAVKDELP QSPGLIHGRE VGEFSVLESD RLKNGMEDAG DTEEFQSDPK 250 260 270 280 290 300 PSQYRKPSLF HQSTSSPYVS KSETHQPMTS GSFPINGLHS HSEVLTARPQ SMENSPTINE 310 320 330 340 350 360 PKDKSSELTR LESVLPRSPA DELSHCVEPE PSQVPGGSSR DRQQGSEEEP SPVLKTLERS 370 380 390 400 410 420 AARKMPSKSL EDISSDSSNQ AKVDNQPEEL VRSAEDVSTV PTQPDNPFSH PDKLKRMSKS 430 440 450 460 470 480 VPAFLQDEVS GSVMSVYSGD FGNLEVKGNI QFAIEYVESL KELHVFVAQC KDLAAADVKK 490 500 510 520 530 540 QRSDPYVKAY LLPDKGKMGK KKTLVVKKTL NPVYNEILRY KIEKQILKTQ KLNLSIWHRD 550 560 570 580 590 600 TFKRNSFLGE VELDLETWDW DNKQNKQLRW YPLKRKTAPV ALEAENRGEM KLALQYVPEP 610 620 630 640 650 660 VPGKKLPTTG EVHIWVKECL DLPLLRGSHL NSFVKCTILP DTSRKSRQKT RAVGKTTNPI 670 680 690 700 710 720 FNHTMVYDGF RPEDLMEACV ELTVWDHYKL TNQFLGGLRI GFGTGKSYGT EVDWMDSTSE 730 740 750 EVALWEKMVN SPNTWIEATL PLRMLLIAKI SK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates in cytotoxic granule secretion." Menasche G., Menager M.M., Lefebvre J.M., Deutsch E., Athman R., Lambert N., Mahlaoui N., Court M., Garin J., Fischer A., de Saint Basile G. Blood 112:5052-5062(2008) [PubMed: 18812475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH RAB27A, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DOMAIN, PROTEOLYTIC PROCESSING, MUTAGENESIS OF GLU-11 AND ARG-32.
[2]	"SGA-72M, a breast cancer-associated antigen." Petroziello J.M., Law C.L., Wahl A.F. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
[3]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed: 10997877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 7; 9; 11 AND 12), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-538 (ISOFORMS 5/6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-462 (ISOFORMS 1 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 260-934 (ISOFORM 8). Tissue: Brain, Colon, Mesenchymal stem cell, Teratocarcinoma, Thalamus, Tongue and Uterus.
[5]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 10). Tissue: Brain, Lung, Mammary gland and Testis.
[8]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 697-934. Tissue: Lymph node.
[9]	"Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain." Yu M., Kasai K., Nagashima K., Torii S., Yokota-Hashimoto H., Okamoto K., Takeuchi T., Gomi H., Izumi T. Mol. Biol. Cell 18:688-696(2007) [PubMed: 17182843] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM 4), FUNCTION, DOMAIN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[10]	"Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse." Holt O., Kanno E., Bossi G., Booth S., Daniele T., Santoro A., Arico M., Saegusa C., Fukuda M., Griffiths G.M. Traffic 9:446-457(2008) [PubMed: 18266782] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[11]	"Elucidation of Rab27 recruitment by its effectors: structure of Rab27a bound to Exophilin4/Slp2-a." Chavas L.M., Ihara K., Kawasaki M., Torii S., Uejima T., Kato R., Izumi T., Wakatsuki S. Structure 16:1468-1477(2008) [PubMed: 18940603] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 10-62, INTERACTION WITH RAB27A.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

EU035829 mRNA. Translation: ABV82746.1.
AY386362 mRNA. Translation: AAR25619.1. Different initiation.
AB046817 mRNA. Translation: BAB13423.1. Sequence problems.
AK000170 mRNA. Translation: BAA90989.1. Sequence problems.
AK024872 mRNA. Translation: BAB15030.1.
AK074737 mRNA. Translation: BAC11170.1.
AK092121 mRNA. Translation: BAG52485.1.
AK124754 mRNA. Translation: BAC85937.1.
AK127504 mRNA. No translation available.
AK131365 mRNA. Translation: BAD18516.1. Different initiation.
AK296224 mRNA. Translation: BAG58947.1.
AK296740 mRNA. Translation: BAG59325.1.
AK298604 mRNA. Translation: BAG60788.1.
AP000642 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW75110.1.
BC015540 mRNA. Translation: AAH15540.2.
BC110315 mRNA. Translation: AAI10316.1.
BC136450 mRNA. Translation: AAI36451.1.
BC144114 mRNA. Translation: AAI44115.1.
BC144115 mRNA. Translation: AAI44116.1.
AL834422 mRNA. Translation: CAD39083.1.

IPI

IPI00059975.
IPI00654696.
IPI00783901.
IPI00784324.
IPI00935700.
IPI00943822.
IPI00943880.
IPI00943912.
IPI00943921.
IPI00943945.
IPI00975471.
IPI00975473.

RefSeq

NP_001156423.1. NM_001162951.1.
NP_001156424.1. NM_001162952.1.
NP_001156425.1. NM_001162953.1.
NP_115755.2. NM_032379.3.
NP_116561.1. NM_032943.3.
NP_996810.1. NM_206927.2.
NP_996811.1. NM_206928.2.
NP_996812.1. NM_206929.2.
NP_996813.1. NM_206930.2.

UniGene

Hs.369520.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3BC1	X-ray	1.80	B/F	10-62	[»]

ProteinModelPortal

Q9HCH5.

SMR

Q9HCH5. Positions 10-56, 626-927.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9HCH5. 1 interaction.

MINT

MINT-1192429.

STRING

Q9HCH5.

PTM databases

PhosphoSite

Q9HCH5.

Polymorphism databases

DMDM

257051068.

Proteomic databases

PRIDE

Q9HCH5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000316356; ENSP00000318803; ENSG00000137501.
ENST00000359152; ENSP00000352065; ENSG00000137501.
ENST00000389956; ENSP00000374606; ENSG00000137501.
ENST00000389958; ENSP00000374608; ENSG00000137501.
ENST00000389959; ENSP00000374609; ENSG00000137501.
ENST00000436296; ENSP00000391277; ENSG00000137501.

GeneID

54843.

KEGG

hsa:54843.

UCSC

uc001pav.1. human.
uc001paw.1. human.
uc001pbe.1. human.
uc001pbf.2. human.

Organism-specific databases

CTD

54843.

GeneCards

GC11M085405.

HGNC

HGNC:15585. SYTL2.

HPA

HPA039651.

MIM

612880. gene.

neXtProt

NX_Q9HCH5.

PharmGKB

PA37985.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG09947.

GeneTree

ENSGT00550000074462.

HOVERGEN

HBG060218.

OrthoDB

EOG4QC15M.

Gene expression databases

ArrayExpress

Q9HCH5.

Bgee

Q9HCH5.

CleanEx

HS_SYTL2.

Genevestigator

Q9HCH5.

GermOnline

ENSG00000137501. Homo sapiens.

Family and domain databases

InterPro

IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR018029. C2_membr_targeting.
IPR010911. Rab-bd_domain.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Gene3D

G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.

Pfam

PF00168. C2. 2 hits.
[Graphical view]

SMART

SM00239. C2. 2 hits.
[Graphical view]

SUPFAM

SSF49562. C2_CaLB. 2 hits.
SSF57903. FYVE_PHD_ZnF. 1 hit.

PROSITE

PS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

57663.

SOURCE

Search...

Entry information

Entry name

SYTL2_HUMAN

Accession

Primary (citable) accession number: Q9HCH5
Secondary accession number(s): B3KRS3 , B4DJT5, B4DKW3, B4DQ26, B7SA85, B7ZLX6, B7ZLX7, Q2YDA7, Q6TV07, Q6ZN59, Q6ZVC5, Q8ND34, Q96BJ2, Q9H768, Q9NXM1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	September 1, 2009
Last modified:	January 25, 2012
This is version 97 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.