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Protein

Copine-5

Gene

CPNE5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).By similarity1 Publication

GO - Biological processi

  • positive regulation of dendrite extension Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124772-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-5Curated
Alternative name(s):
Copine VBy similarityImported
Gene namesi
Name:CPNE5Imported
Synonyms:KIAA15991 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:2318. CPNE5.

Subcellular locationi

  • Perikaryon By similarity
  • Cell projection By similarity

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • neuron projection Source: Ensembl
  • perikaryon Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection

Pathology & Biotechi

Organism-specific databases

DisGeNETi57699.
OpenTargetsiENSG00000124772.
PharmGKBiPA26835.

Polymorphism and mutation databases

BioMutaiCPNE5.
DMDMi13626179.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448431 – 593Copine-5Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1
Modified residuei103PhosphoserineBy similarity1
Modified residuei140PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HCH3.
MaxQBiQ9HCH3.
PaxDbiQ9HCH3.
PeptideAtlasiQ9HCH3.
PRIDEiQ9HCH3.

PTM databases

iPTMnetiQ9HCH3.
PhosphoSitePlusiQ9HCH3.

Expressioni

Tissue specificityi

Expressed in the brain, heart, stomach, spleen, lymph node and testis (PubMed:12949241). Expressed in melanocytes (PubMed:23999003).2 Publications

Gene expression databases

BgeeiENSG00000124772.
CleanExiHS_CPNE5.
ExpressionAtlasiQ9HCH3. baseline and differential.
GenevisibleiQ9HCH3. HS.

Organism-specific databases

HPAiHPA031369.

Interactioni

Protein-protein interaction databases

BioGridi121724. 30 interactors.
STRINGi9606.ENSP00000244751.

Structurei

3D structure databases

ProteinModelPortaliQ9HCH3.
SMRiQ9HCH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 116C2 1PROSITE-ProRule annotationAdd BLAST88
Domaini147 – 268C2 2PROSITE-ProRule annotationAdd BLAST122
Domaini328 – 554VWFAPROSITE-ProRule annotationAdd BLAST227

Sequence similaritiesi

Belongs to the copine family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327. Eukaryota.
ENOG410XPC8. LUCA.
GeneTreeiENSGT00760000119085.
HOGENOMiHOG000220898.
HOVERGENiHBG066841.
InParanoidiQ9HCH3.
OMAiNGNMENP.
OrthoDBiEOG091G05IT.
PhylomeDBiQ9HCH3.
TreeFamiTF316419.

Family and domain databases

CDDicd01459. vWA_copine_like. 1 hit.
Gene3Di2.60.40.150. 2 hits.
3.40.50.410. 1 hit.
InterProiIPR000008. C2_dom.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQPEDMASL SEFDSLAGSI PATKVEITVS CRNLLDKDMF SKSDPLCVMY
60 70 80 90 100
TQGMENKQWR EFGRTEVIDN TLNPDFVRKF IVDYFFEEKQ NLRFDLYDVD
110 120 130 140 150
SKSPDLSKHD FLGQAFCTLG EIVGSPGSRL EKPLTIGAFS LNSRTGKPMP
160 170 180 190 200
AVSNGGVPGK KCGTIILSAE ELSNCRDVAT MQFCANKLDK KDFFGKSDPF
210 220 230 240 250
LVFYRSNEDG TFTICHKTEV MKNTLNPVWQ TFSIPVRALC NGDYDRTIKV
260 270 280 290 300
EVYDWDRDGS HDFIGEFTTS YRELARGQSQ FNIYEVVNPK KKMKKKKYVN
310 320 330 340 350
SGTVTLLSFA VESECTFLDY IKGGTQINFT VAIDFTASNG NPSQSTSLHY
360 370 380 390 400
MSPYQLNAYA LALTAVGEII QHYDSDKMFP ALGFGAKLPP DGRVSHEFPL
410 420 430 440 450
NGNQENPSCC GIDGILEAYH RSLRTVQLYG PTNFAPVVTH VARNAAAVQD
460 470 480 490 500
GSQYSVLLII TDGVISDMAQ TKEAIVNAAK LPMSIIIVGV GQAEFDAMVE
510 520 530 540 550
LDGDDVRISS RGKLAERDIV QFVPFRDYVD RTGNHVLSMA RLARDVLAEI
560 570 580 590
PDQLVSYMKA QGIRPRPPPA APTHSPSQSP ARTPPASPLH THI
Length:593
Mass (Da):65,734
Last modified:April 27, 2001 - v2
Checksum:i7C470A51B70A5162
GO
Isoform 2 (identifier: Q9HCH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-292: Missing.

Note: No experimental confirmation available.
Show »
Length:301
Mass (Da):32,627
Checksum:i12B09B9A07DF7C32
GO

Sequence cautioni

The sequence BAB13425 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02035833N → S.Corresponds to variant rs3734334dbSNPEnsembl.1
Natural variantiVAR_021954582R → H.Corresponds to variant rs3830138dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565351 – 292Missing in isoform 2. 1 PublicationAdd BLAST292

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046819 mRNA. Translation: BAB13425.1. Different initiation.
Z85996 Genomic DNA. Translation: CAD92810.1.
CH471081 Genomic DNA. Translation: EAX03914.1.
BC053872 mRNA. Translation: AAH53872.1.
CCDSiCCDS4825.1. [Q9HCH3-1]
CCDS83078.1. [Q9HCH3-2]
RefSeqiNP_001300947.1. NM_001314018.1. [Q9HCH3-2]
NP_001300948.1. NM_001314019.1.
NP_001300949.1. NM_001314020.1.
NP_065990.1. NM_020939.1. [Q9HCH3-1]
UniGeneiHs.657869.

Genome annotation databases

EnsembliENST00000244751; ENSP00000244751; ENSG00000124772. [Q9HCH3-1]
ENST00000393189; ENSP00000376885; ENSG00000124772. [Q9HCH3-2]
GeneIDi57699.
KEGGihsa:57699.
UCSCiuc003omp.2. human. [Q9HCH3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046819 mRNA. Translation: BAB13425.1. Different initiation.
Z85996 Genomic DNA. Translation: CAD92810.1.
CH471081 Genomic DNA. Translation: EAX03914.1.
BC053872 mRNA. Translation: AAH53872.1.
CCDSiCCDS4825.1. [Q9HCH3-1]
CCDS83078.1. [Q9HCH3-2]
RefSeqiNP_001300947.1. NM_001314018.1. [Q9HCH3-2]
NP_001300948.1. NM_001314019.1.
NP_001300949.1. NM_001314020.1.
NP_065990.1. NM_020939.1. [Q9HCH3-1]
UniGeneiHs.657869.

3D structure databases

ProteinModelPortaliQ9HCH3.
SMRiQ9HCH3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121724. 30 interactors.
STRINGi9606.ENSP00000244751.

PTM databases

iPTMnetiQ9HCH3.
PhosphoSitePlusiQ9HCH3.

Polymorphism and mutation databases

BioMutaiCPNE5.
DMDMi13626179.

Proteomic databases

EPDiQ9HCH3.
MaxQBiQ9HCH3.
PaxDbiQ9HCH3.
PeptideAtlasiQ9HCH3.
PRIDEiQ9HCH3.

Protocols and materials databases

DNASUi57699.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244751; ENSP00000244751; ENSG00000124772. [Q9HCH3-1]
ENST00000393189; ENSP00000376885; ENSG00000124772. [Q9HCH3-2]
GeneIDi57699.
KEGGihsa:57699.
UCSCiuc003omp.2. human. [Q9HCH3-1]

Organism-specific databases

CTDi57699.
DisGeNETi57699.
GeneCardsiCPNE5.
HGNCiHGNC:2318. CPNE5.
HPAiHPA031369.
MIMi604209. gene.
neXtProtiNX_Q9HCH3.
OpenTargetsiENSG00000124772.
PharmGKBiPA26835.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1327. Eukaryota.
ENOG410XPC8. LUCA.
GeneTreeiENSGT00760000119085.
HOGENOMiHOG000220898.
HOVERGENiHBG066841.
InParanoidiQ9HCH3.
OMAiNGNMENP.
OrthoDBiEOG091G05IT.
PhylomeDBiQ9HCH3.
TreeFamiTF316419.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124772-MONOMER.

Miscellaneous databases

ChiTaRSiCPNE5. human.
GenomeRNAii57699.
PROiQ9HCH3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124772.
CleanExiHS_CPNE5.
ExpressionAtlasiQ9HCH3. baseline and differential.
GenevisibleiQ9HCH3. HS.

Family and domain databases

CDDicd01459. vWA_copine_like. 1 hit.
Gene3Di2.60.40.150. 2 hits.
3.40.50.410. 1 hit.
InterProiIPR000008. C2_dom.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPNE5_HUMAN
AccessioniPrimary (citable) accession number: Q9HCH3
Secondary accession number(s): Q7Z6C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 30, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.