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Q9HCG1

- ZN160_HUMAN

UniProt

Q9HCG1 - ZN160_HUMAN

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Protein

Zinc finger protein 160

Gene

ZNF160

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri257 – 27923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri649 – 67123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri677 – 69923C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 72723C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri733 – 75523C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri761 – 78323C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri789 – 81123C2H2-type 20PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hemopoiesis Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 160
Alternative name(s):
Zinc finger protein HZF5
Zinc finger protein Kr18
Short name:
HKr18
Gene namesi
Name:ZNF160
Synonyms:KIAA1611
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:12948. ZNF160.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37531.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 818818Zinc finger protein 160PRO_0000047433Add
BLAST

Proteomic databases

PaxDbiQ9HCG1.
PRIDEiQ9HCG1.

PTM databases

PhosphoSiteiQ9HCG1.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ9HCG1.
CleanExiHS_ZNF160.
ExpressionAtlasiQ9HCG1. baseline and differential.
GenevestigatoriQ9HCG1.

Organism-specific databases

HPAiHPA023599.

Interactioni

Protein-protein interaction databases

BioGridi124698. 3 interactions.
IntActiQ9HCG1. 4 interactions.
STRINGi9606.ENSP00000270457.

Structurei

3D structure databases

ProteinModelPortaliQ9HCG1.
SMRiQ9HCG1. Positions 8-48, 214-818.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 20 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri257 – 27923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri649 – 67123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri677 – 69923C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 72723C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri733 – 75523C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri761 – 78323C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri789 – 81123C2H2-type 20PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118783.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9HCG1.
KOiK09228.
OMAiQNENIAG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9HCG1.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 20 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 20 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 20 hits.
PS50157. ZINC_FINGER_C2H2_2. 20 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HCG1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTQVRLTF RDVAIEFSQE EWKCLDPAQR ILYRDVMLEN YWNLVSLGLC
60 70 80 90 100
HFDMNIISML EEGKEPWTVK SCVKIARKPR TPECVKGVVT DIPPKCTIKD
110 120 130 140 150
LLPKEKSSTE AVFHTVVLER HESPDIEDFS FKEPQKNVHD FECQWRDDTG
160 170 180 190 200
NYKGVLMAQK EGKRDQRDRR DIENKLMNNQ LGVSFHSHLP ELQLFQGEGK
210 220 230 240 250
MYECNQVEKS TNNGSSVSPL QQIPSSVQTH RSKKYHELNH FSLLTQRRKA
260 270 280 290 300
NSCGKPYKCN ECGKAFTQNS NLTSHRRIHS GEKPYKCSEC GKTFTVRSNL
310 320 330 340 350
TIHQVIHTGE KPYKCHECGK VFRHNSYLAT HRRIHTGEKP YKCNECGKAF
360 370 380 390 400
RGHSNLTTHQ LIHTGEKPFK CNECGKLFTQ NSHLISHWRI HTGEKPYKCN
410 420 430 440 450
ECGKAFSVRS SLAIHQTIHT GEKPYKCNEC GKVFRYNSYL GRHRRVHTGE
460 470 480 490 500
KPYKCNECGK AFSMHSNLAT HQVIHTGTKP FKCNECSKVF TQNSQLANHR
510 520 530 540 550
RIHTGEKPYK CNECGKAFSV RSSLTTHQAI HSGEKPYKCI ECGKSFTQKS
560 570 580 590 600
HLRSHRGIHS GEKPYKCNEC GKVFAQTSQL ARHWRVHTGE KPYKCNDCGR
610 620 630 640 650
AFSDRSSLTF HQAIHTGEKP YKCHECGKVF RHNSYLATHR RIHTGEKPYK
660 670 680 690 700
CNECGKAFSM HSNLTTHKVI HTGEKPYKCN QCGKVFTQNS HLANHQRTHT
710 720 730 740 750
GEKPYRCNEC GKAFSVRSSL TTHQAIHTGK KPYKCNECGK VFTQNAHLAN
760 770 780 790 800
HRRIHTGEKP YRCTECGKAF RVRSSLTTHM AIHTGEKRYK CNECGKVFRQ
810
SSNLASHHRM HTGEKPYK
Length:818
Mass (Da):94,112
Last modified:May 18, 2010 - v3
Checksum:i00C5BE5E3E74B76B
GO
Isoform 2 (identifier: Q9HCG1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-147: IPPKCTIKDL...VHDFECQWRD → LLRRWKHWLL...VCDKRVGSIF
     148-818: Missing.

Note: No experimental confirmation available.

Show »
Length:147
Mass (Da):17,112
Checksum:i83D6F9CBB03F4735
GO

Sequence cautioni

The sequence CAA55528.1 differs from that shown. Reason: Dubious alternative splicing.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71R → Q.
Corresponds to variant rs329709 [ dbSNP | Ensembl ].
VAR_057400
Natural varianti82 – 821P → R.2 Publications
Corresponds to variant rs8105668 [ dbSNP | Ensembl ].
VAR_060274

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei92 – 14756IPPKC…CQWRD → LLRRWKHWLLLLGICCPKPH GRVSSRLRLSRSLGHFFHSA FATFMGVCDKRVGSIF in isoform 2. 1 PublicationVSP_055940Add
BLAST
Alternative sequencei148 – 818671Missing in isoform 2. 1 PublicationVSP_055941Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010328 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72110.1.
BC000807 mRNA. Translation: AAH00807.1.
BC094880 mRNA. Translation: AAH94880.1.
AF277623 mRNA. Translation: AAK61306.1.
AB046831 mRNA. Translation: BAB13437.1.
AK024442 mRNA. Translation: BAB15732.1.
X78928 mRNA. Translation: CAA55528.1. Sequence problems.
CCDSiCCDS12859.1. [Q9HCG1-1]
PIRiS47066.
RefSeqiNP_001096073.1. NM_001102603.1.
NP_150630.2. NM_033288.3.
NP_942596.1. NM_198893.2.
XP_005259435.1. XM_005259378.2.
XP_006723524.1. XM_006723461.1.
XP_006723525.1. XM_006723462.1.
UniGeneiHs.655967.

Genome annotation databases

EnsembliENST00000355147; ENSP00000347273; ENSG00000170949. [Q9HCG1-2]
ENST00000418871; ENSP00000409597; ENSG00000170949. [Q9HCG1-1]
ENST00000429604; ENSP00000406201; ENSG00000170949. [Q9HCG1-1]
ENST00000599056; ENSP00000470961; ENSG00000170949. [Q9HCG1-1]
GeneIDi90338.
KEGGihsa:90338.
UCSCiuc002qaq.4. human. [Q9HCG1-1]

Polymorphism databases

DMDMi296453072.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010328 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72110.1 .
BC000807 mRNA. Translation: AAH00807.1 .
BC094880 mRNA. Translation: AAH94880.1 .
AF277623 mRNA. Translation: AAK61306.1 .
AB046831 mRNA. Translation: BAB13437.1 .
AK024442 mRNA. Translation: BAB15732.1 .
X78928 mRNA. Translation: CAA55528.1 . Sequence problems.
CCDSi CCDS12859.1. [Q9HCG1-1 ]
PIRi S47066.
RefSeqi NP_001096073.1. NM_001102603.1.
NP_150630.2. NM_033288.3.
NP_942596.1. NM_198893.2.
XP_005259435.1. XM_005259378.2.
XP_006723524.1. XM_006723461.1.
XP_006723525.1. XM_006723462.1.
UniGenei Hs.655967.

3D structure databases

ProteinModelPortali Q9HCG1.
SMRi Q9HCG1. Positions 8-48, 214-818.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124698. 3 interactions.
IntActi Q9HCG1. 4 interactions.
STRINGi 9606.ENSP00000270457.

PTM databases

PhosphoSitei Q9HCG1.

Polymorphism databases

DMDMi 296453072.

Proteomic databases

PaxDbi Q9HCG1.
PRIDEi Q9HCG1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355147 ; ENSP00000347273 ; ENSG00000170949 . [Q9HCG1-2 ]
ENST00000418871 ; ENSP00000409597 ; ENSG00000170949 . [Q9HCG1-1 ]
ENST00000429604 ; ENSP00000406201 ; ENSG00000170949 . [Q9HCG1-1 ]
ENST00000599056 ; ENSP00000470961 ; ENSG00000170949 . [Q9HCG1-1 ]
GeneIDi 90338.
KEGGi hsa:90338.
UCSCi uc002qaq.4. human. [Q9HCG1-1 ]

Organism-specific databases

CTDi 90338.
GeneCardsi GC19M053569.
HGNCi HGNC:12948. ZNF160.
HPAi HPA023599.
MIMi 600398. gene.
neXtProti NX_Q9HCG1.
PharmGKBi PA37531.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118783.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9HCG1.
KOi K09228.
OMAi QNENIAG.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9HCG1.
TreeFami TF341892.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF160. human.
GeneWikii ZNF160.
GenomeRNAii 90338.
NextBioi 76679.
PROi Q9HCG1.
SOURCEi Search...

Gene expression databases

Bgeei Q9HCG1.
CleanExi HS_ZNF160.
ExpressionAtlasi Q9HCG1. baseline and differential.
Genevestigatori Q9HCG1.

Family and domain databases

Gene3Di 3.30.160.60. 20 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 20 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 20 hits.
PS50157. ZINC_FINGER_C2H2_2. 20 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lymph and Placenta.
  4. "Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19."
    Mark C., Looman C., Abrink M., Hellman L.
    DNA Cell Biol. 20:275-286(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-556 (ISOFORM 1), TISSUE SPECIFICITY, VARIANT ARG-82.
    Tissue: Testis.
  5. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-818 (ISOFORM 1), VARIANT ARG-82.
    Tissue: Brain.
  6. "Characterization of long cDNA clones from human adult spleen."
    Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.
    DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-818 (ISOFORM 1).
    Tissue: Spleen.
  7. "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
    Abrink M., Aveskogh M., Hellman L.
    DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 685-818 (ISOFORM 1).

Entry informationi

Entry nameiZN160_HUMAN
AccessioniPrimary (citable) accession number: Q9HCG1
Secondary accession number(s): Q14589
, Q504Q8, Q96JC5, Q9BVY9, Q9H7N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3