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Q9HCG1 (ZN160_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 160
Alternative name(s):
Zinc finger protein HZF5
Zinc finger protein Kr18
Short name=HKr18
Gene names
Name:ZNF160
Synonyms:KIAA1611
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length818 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Tissue specificity

Ubiquitous. Ref.3

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 20 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence CAA55528.1 differs from that shown. Reason: Dubious alternative splicing.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhemopoiesis

Non-traceable author statement Ref.3. Source: UniProtKB

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 818818Zinc finger protein 160
PRO_0000047433

Regions

Domain8 – 7972KRAB
Zinc finger257 – 27923C2H2-type 1
Zinc finger285 – 30723C2H2-type 2
Zinc finger313 – 33523C2H2-type 3
Zinc finger341 – 36323C2H2-type 4
Zinc finger369 – 39123C2H2-type 5
Zinc finger397 – 41923C2H2-type 6
Zinc finger425 – 44723C2H2-type 7
Zinc finger453 – 47523C2H2-type 8
Zinc finger481 – 50323C2H2-type 9
Zinc finger509 – 53123C2H2-type 10
Zinc finger537 – 55923C2H2-type 11
Zinc finger565 – 58723C2H2-type 12
Zinc finger593 – 61523C2H2-type 13
Zinc finger621 – 64323C2H2-type 14
Zinc finger649 – 67123C2H2-type 15
Zinc finger677 – 69923C2H2-type 16
Zinc finger705 – 72723C2H2-type 17
Zinc finger733 – 75523C2H2-type 18
Zinc finger761 – 78323C2H2-type 19
Zinc finger789 – 81123C2H2-type 20

Natural variations

Natural variant71R → Q.
Corresponds to variant rs329709 [ dbSNP | Ensembl ].
VAR_057400
Natural variant821P → R. Ref.3 Ref.4
Corresponds to variant rs8105668 [ dbSNP | Ensembl ].
VAR_060274

Sequences

Sequence LengthMass (Da)Tools
Q9HCG1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 00C5BE5E3E74B76B

FASTA81894,112
        10         20         30         40         50         60 
MALTQVRLTF RDVAIEFSQE EWKCLDPAQR ILYRDVMLEN YWNLVSLGLC HFDMNIISML 

        70         80         90        100        110        120 
EEGKEPWTVK SCVKIARKPR TPECVKGVVT DIPPKCTIKD LLPKEKSSTE AVFHTVVLER 

       130        140        150        160        170        180 
HESPDIEDFS FKEPQKNVHD FECQWRDDTG NYKGVLMAQK EGKRDQRDRR DIENKLMNNQ 

       190        200        210        220        230        240 
LGVSFHSHLP ELQLFQGEGK MYECNQVEKS TNNGSSVSPL QQIPSSVQTH RSKKYHELNH 

       250        260        270        280        290        300 
FSLLTQRRKA NSCGKPYKCN ECGKAFTQNS NLTSHRRIHS GEKPYKCSEC GKTFTVRSNL 

       310        320        330        340        350        360 
TIHQVIHTGE KPYKCHECGK VFRHNSYLAT HRRIHTGEKP YKCNECGKAF RGHSNLTTHQ 

       370        380        390        400        410        420 
LIHTGEKPFK CNECGKLFTQ NSHLISHWRI HTGEKPYKCN ECGKAFSVRS SLAIHQTIHT 

       430        440        450        460        470        480 
GEKPYKCNEC GKVFRYNSYL GRHRRVHTGE KPYKCNECGK AFSMHSNLAT HQVIHTGTKP 

       490        500        510        520        530        540 
FKCNECSKVF TQNSQLANHR RIHTGEKPYK CNECGKAFSV RSSLTTHQAI HSGEKPYKCI 

       550        560        570        580        590        600 
ECGKSFTQKS HLRSHRGIHS GEKPYKCNEC GKVFAQTSQL ARHWRVHTGE KPYKCNDCGR 

       610        620        630        640        650        660 
AFSDRSSLTF HQAIHTGEKP YKCHECGKVF RHNSYLATHR RIHTGEKPYK CNECGKAFSM 

       670        680        690        700        710        720 
HSNLTTHKVI HTGEKPYKCN QCGKVFTQNS HLANHQRTHT GEKPYRCNEC GKAFSVRSSL 

       730        740        750        760        770        780 
TTHQAIHTGK KPYKCNECGK VFTQNAHLAN HRRIHTGEKP YRCTECGKAF RVRSSLTTHM 

       790        800        810 
AIHTGEKRYK CNECGKVFRQ SSNLASHHRM HTGEKPYK 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph.
[3]"Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19."
Mark C., Looman C., Abrink M., Hellman L.
DNA Cell Biol. 20:275-286(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-556, TISSUE SPECIFICITY, VARIANT ARG-82.
Tissue: Testis.
[4]"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-818, VARIANT ARG-82.
Tissue: Brain.
[5]"Characterization of long cDNA clones from human adult spleen."
Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.
DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-818.
Tissue: Spleen.
[6]"Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
Abrink M., Aveskogh M., Hellman L.
DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 685-818.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC010328 Genomic DNA. No translation available.
BC094880 mRNA. Translation: AAH94880.1.
AF277623 mRNA. Translation: AAK61306.1.
AB046831 mRNA. Translation: BAB13437.1.
AK024442 mRNA. Translation: BAB15732.1.
X78928 mRNA. Translation: CAA55528.1. Sequence problems.
PIRS47066.
RefSeqNP_001096073.1. NM_001102603.1.
NP_150630.2. NM_033288.3.
NP_942596.1. NM_198893.2.
XP_005259435.1. XM_005259378.2.
UniGeneHs.655967.

3D structure databases

ProteinModelPortalQ9HCG1.
SMRQ9HCG1. Positions 8-48, 214-818.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124698. 3 interactions.
IntActQ9HCG1. 4 interactions.
STRING9606.ENSP00000270457.

PTM databases

PhosphoSiteQ9HCG1.

Polymorphism databases

DMDM296453072.

Proteomic databases

PaxDbQ9HCG1.
PRIDEQ9HCG1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000418871; ENSP00000409597; ENSG00000170949.
ENST00000429604; ENSP00000406201; ENSG00000170949.
ENST00000599056; ENSP00000470961; ENSG00000170949.
GeneID90338.
KEGGhsa:90338.
UCSCuc002qaq.4. human.

Organism-specific databases

CTD90338.
GeneCardsGC19M053569.
HGNCHGNC:12948. ZNF160.
HPAHPA023599.
MIM600398. gene.
neXtProtNX_Q9HCG1.
PharmGKBPA37531.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ9HCG1.
KOK09228.
OMAQNENIAG.
OrthoDBEOG7KSX7Q.
PhylomeDBQ9HCG1.
TreeFamTF341892.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9HCG1.
BgeeQ9HCG1.
CleanExHS_ZNF160.
GenevestigatorQ9HCG1.

Family and domain databases

Gene3D3.30.160.60. 20 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 20 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 20 hits.
PS50157. ZINC_FINGER_C2H2_2. 20 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF160. human.
GeneWikiZNF160.
GenomeRNAi90338.
NextBio76679.
PROQ9HCG1.
SOURCESearch...

Entry information

Entry nameZN160_HUMAN
AccessionPrimary (citable) accession number: Q9HCG1
Secondary accession number(s): Q14589 expand/collapse secondary AC list , Q504Q8, Q96JC5, Q9H7N6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM