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Q9HCF6

- TRPM3_HUMAN

UniProt

Q9HCF6 - TRPM3_HUMAN

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Protein

Transient receptor potential cation channel subfamily M member 3

Gene

TRPM3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.2 Publications

GO - Molecular functioni

  1. calcium activated cation channel activity Source: InterPro
  2. calcium channel activity Source: UniProtKB-KW
  3. cation channel activity Source: MGI

GO - Biological processi

  1. calcium ion transmembrane transport Source: Reactome
  2. cation transport Source: MGI
  3. detection of temperature stimulus Source: InterPro
  4. ion transmembrane transport Source: Reactome
  5. sensory perception of temperature stimulus Source: InterPro
  6. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_169333. TRP channels.

Protein family/group databases

TCDBi1.A.4.5.6. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 3
Alternative name(s):
Long transient receptor potential channel 3
Short name:
LTrpC-3
Short name:
LTrpC3
Melastatin-2
Short name:
MLSN2
Gene namesi
Name:TRPM3
Synonyms:KIAA1616, LTRPC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:17992. TRPM3.

Subcellular locationi

Membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38271.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17321732Transient receptor potential cation channel subfamily M member 3PRO_0000215328Add
BLAST

Proteomic databases

MaxQBiQ9HCF6.
PaxDbiQ9HCF6.
PRIDEiQ9HCF6.

PTM databases

PhosphoSiteiQ9HCF6.

Expressioni

Tissue specificityi

Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney.2 Publications

Gene expression databases

BgeeiQ9HCF6.
ExpressionAtlasiQ9HCF6. baseline and differential.
GenevestigatoriQ9HCF6.

Interactioni

Protein-protein interaction databases

BioGridi123085. 2 interactions.
MINTiMINT-4713703.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 794770CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini816 – 89782ExtracellularSequence AnalysisAdd
BLAST
Topological domaini919 – 96446CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini986 – 99510ExtracellularSequence Analysis
Topological domaini1017 – 102812CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1050 – 111667ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1138 – 1732595CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Transmembranei795 – 81521HelicalSequence AnalysisAdd
BLAST
Transmembranei898 – 91821HelicalSequence AnalysisAdd
BLAST
Transmembranei965 – 98521HelicalSequence AnalysisAdd
BLAST
Transmembranei996 – 101621HelicalSequence AnalysisAdd
BLAST
Transmembranei1029 – 104921HelicalSequence AnalysisAdd
BLAST
Transmembranei1117 – 113721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1241 – 130161Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253824.
GeneTreeiENSGT00760000119127.
HOGENOMiHOG000230920.
HOVERGENiHBG058254.
InParanoidiQ9HCF6.
KOiK04978.
OMAiKFWFYTL.
OrthoDBiEOG7NPFSC.
PhylomeDBiQ9HCF6.
TreeFamiTF314204.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029583. TRPM3.
[Graphical view]
PANTHERiPTHR13800:SF7. PTHR13800:SF7. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]

Sequences (11)i

Sequence statusi: Complete.

This entry describes 11 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HCF6-1) [UniParc]FASTAAdd to Basket

Also known as: TRPM3f

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEPWGTVYF LGIAQVFSFL FSWWNLEGVM NQADAPRPLN WTIRKLCHAA
60 70 80 90 100
FLPSVRLLKA QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT
110 120 130 140 150
PSISVLQNEK NESRLSRNDI QSEKWSISKH TQLSPTDAFG TIEFQGGGHS
160 170 180 190 200
NKAMYVRVSF DTKPDLLLHL MTKEWQLELP KLLISVHGGL QNFELQPKLK
210 220 230 240 250
QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS KSRGKICTIG
260 270 280 290 300
IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT
310 320 330 340 350
GKYGAEVKLR RQLEKHISLQ KINTRCLPFF SLDSRLFYSF WGSCQLDSVG
360 370 380 390 400
IGQGVPVVAL IVEGGPNVIS IVLEYLRDTP PVPVVVCDGS GRASDILAFG
410 420 430 440 450
HKYSEEGGLI NESLRDQLLV TIQKTFTYTR TQAQHLFIIL MECMKKKELI
460 470 480 490 500
TVFRMGSEGH QDIDLAILTA LLKGANASAP DQLSLALAWN RVDIARSQIF
510 520 530 540 550
IYGQQWPVGS LEQAMLDALV LDRVDFVKLL IENGVSMHRF LTISRLEELY
560 570 580 590 600
NTRHGPSNTL YHLVRDVKKG NLPPDYRISL IDIGLVIEYL MGGAYRCNYT
610 620 630 640 650
RKRFRTLYHN LFGPKRPKAL KLLGMEDDIP LRRGRKTTKK REEEVDIDLD
660 670 680 690 700
DPEINHFPFP FHELMVWAVL MKRQKMALFF WQHGEEAMAK ALVACKLCKA
710 720 730 740 750
MAHEASENDM VDDISQELNH NSRDFGQLAV ELLDQSYKQD EQLAMKLLTY
760 770 780 790 800
ELKNWSNATC LQLAVAAKHR DFIAHTCSQM LLTDMWMGRL RMRKNSGLKV
810 820 830 840 850
ILGILLPPSI LSLEFKNKDD MPYMSQAQEI HLQEKEAEEP EKPTKEKEEE
860 870 880 890 900
DMELTAMLGR NNGESSRKKD EEEVQSKHRL IPLGRKIYEF YNAPIVKFWF
910 920 930 940 950
YTLAYIGYLM LFNYIVLVKM ERWPSTQEWI VISYIFTLGI EKMREILMSE
960 970 980 990 1000
PGKLLQKVKV WLQEYWNVTD LIAILLFSVG MILRLQDQPF RSDGRVIYCV
1010 1020 1030 1040 1050
NIIYWYIRLL DIFGVNKYLG PYVMMIGKMM IDMMYFVIIM LVVLMSFGVA
1060 1070 1080 1090 1100
RQAILFPNEE PSWKLAKNIF YMPYWMIYGE VFADQIDPPC GQNETREDGK
1110 1120 1130 1140 1150
IIQLPPCKTG AWIVPAIMAC YLLVANILLV NLLIAVFNNT FFEVKSISNQ
1160 1170 1180 1190 1200
VWKFQRYQLI MTFHERPVLP PPLIIFSHMT MIFQHLCCRW RKHESDPDER
1210 1220 1230 1240 1250
DYGLKLFITD DELKKVHDFE EQCIEEYFRE KDDRFNSSND ERIRVTSERV
1260 1270 1280 1290 1300
ENMSMRLEEV NEREHSMKAS LQTVDIRLAQ LEDLIGRMAT ALERLTGLER
1310 1320 1330 1340 1350
AESNKIRSRT SSDCTDAAYI VRQSSFNSQE GNTFKLQESI DPAGEETMSP
1360 1370 1380 1390 1400
TSPTLMPRMR SHSFYSVNMK DKGGIEKLES IFKERSLSLH RATSSHSVAK
1410 1420 1430 1440 1450
EPKAPAAPAN TLAIVPDSRR PSSCIDIYVS AMDELHCDID PLDNSVNILG
1460 1470 1480 1490 1500
LGEPSFSTPV PSTAPSSSAY ATLAPTDRPP SRSIDFEDIT SMDTRSFSSD
1510 1520 1530 1540 1550
YTHLPECQNP WDSEPPMYHT IERSKSSRYL ATTPFLLEEA PIVKSHSFMF
1560 1570 1580 1590 1600
SPSRSYYANF GVPVKTAEYT SITDCIDTRC VNAPQAIADR AAFPGGLGDK
1610 1620 1630 1640 1650
VEDLTCCHPE REAELSHPSS DSEENEAKGR RATIAISSQE GDNSERTLSN
1660 1670 1680 1690 1700
NITVPKIERA NSYSAEEPSA PYAHTRKSFS ISDKLDRQRN TASLRNPFQR
1710 1720 1730
SKSSKPEGRG DSLSMRRLSR TSAFQSFESK HN
Length:1,732
Mass (Da):197,571
Last modified:February 8, 2011 - v4
Checksum:i0D6BE312C56646A4
GO
Isoform 2 (identifier: Q9HCF6-2) [UniParc]FASTAAdd to Basket

Also known as: TRPM3a

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.

Show »
Length:1,707
Mass (Da):194,714
Checksum:i16522E65FD2FAA3F
GO
Isoform 3 (identifier: Q9HCF6-3) [UniParc]FASTAAdd to Basket

Also known as: TRPM3b

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     569-569: K → KREYPGFGWIYFK

Show »
Length:1,719
Mass (Da):196,259
Checksum:i27EAFF76AFB0A46B
GO
Isoform 4 (identifier: Q9HCF6-4) [UniParc]FASTAAdd to Basket

Also known as: TRPM3d

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     617-626: Missing.

Show »
Length:1,697
Mass (Da):193,632
Checksum:i144786F6D67B4F0B
GO
Isoform 5 (identifier: Q9HCF6-5) [UniParc]FASTAAdd to Basket

Also known as: TRPM3e

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     569-569: K → KREYPGFGWIYFK
     617-626: Missing.

Show »
Length:1,709
Mass (Da):195,177
Checksum:iDA6133571BA70002
GO
Isoform 6 (identifier: Q9HCF6-6) [UniParc]FASTAAdd to Basket

Also known as: TRPM3c

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     1088-1088: P → RKQVYDSHTPKSA

Show »
Length:1,719
Mass (Da):196,115
Checksum:i46BEADD398188191
GO
Isoform 7 (identifier: Q9HCF6-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     617-626: Missing.

Show »
Length:1,722
Mass (Da):196,490
Checksum:iE30BDDE5FB3E061B
GO
Isoform 8 (identifier: Q9HCF6-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     535-552: Missing.
     617-626: Missing.

Show »
Length:1,679
Mass (Da):191,441
Checksum:iC90DF3FAF79D9637
GO
Isoform 10 (identifier: Q9HCF6-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     1344-1350: GEETMSP → EHPLYSV
     1351-1732: Missing.

Show »
Length:1,325
Mass (Da):152,656
Checksum:i837BEDE795F5E400
GO
Isoform 11 (identifier: Q9HCF6-11) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: MPEPWGTVYF...AFLPSVRLLK → MGKKWRDAAE...RSGLPSQQTP

Show »
Length:1,734
Mass (Da):197,679
Checksum:iD536EBCD7F526C10
GO
Isoform 12 (identifier: Q9HCF6-12) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     326-350: Missing.
     409-1732: Missing.

Note: No experimental confirmation available.

Show »
Length:230
Mass (Da):25,159
Checksum:i237AF35F9D6036F2
GO

Sequence cautioni

The sequence CAB66480.2 differs from that shown. Reason: Cloning artifact in C-terminus.
The sequence CAM13096.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAM13169.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAM15782.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAM17596.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAM22746.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti335 – 3351R → H in BAC55103. 1 PublicationCurated
Sequence conflicti695 – 6951C → Y in BAC55106. 1 PublicationCurated
Sequence conflicti1032 – 10321D → E in BAC55106. 1 PublicationCurated
Sequence conflicti1730 – 17301K → Q in BAC55104. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1653 – 16531T → I.
Corresponds to variant rs13440436 [ dbSNP | Ensembl ].
VAR_057305
Natural varianti1695 – 16951R → Q.
Corresponds to variant rs6560142 [ dbSNP | Ensembl ].
VAR_021257
Natural varianti1717 – 17171R → K.1 Publication
Corresponds to variant rs41287373 [ dbSNP | Ensembl ].
VAR_061862
Natural varianti1732 – 17321N → T.3 Publications
Corresponds to variant rs17535963 [ dbSNP | Ensembl ].
VAR_057306

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 153153Missing in isoform 12. 1 PublicationVSP_043515Add
BLAST
Alternative sequencei1 – 5959MPEPW…VRLLK → MGKKWRDAAEMERGCSDRED NAESRRRSRSASRGRFAESW KRLSSKQGSTKRSGLPSQQT P in isoform 11. 1 PublicationVSP_039107Add
BLAST
Alternative sequencei326 – 35025Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 8, isoform 10 and isoform 12. 4 PublicationsVSP_012826Add
BLAST
Alternative sequencei409 – 17321324Missing in isoform 12. 1 PublicationVSP_043516Add
BLAST
Alternative sequencei535 – 55218Missing in isoform 8. 1 PublicationVSP_012827Add
BLAST
Alternative sequencei569 – 5691K → KREYPGFGWIYFK in isoform 3 and isoform 5. 1 PublicationVSP_012828
Alternative sequencei617 – 62610Missing in isoform 4, isoform 5, isoform 7 and isoform 8. 2 PublicationsVSP_012829
Alternative sequencei1088 – 10881P → RKQVYDSHTPKSA in isoform 6. 1 PublicationVSP_012830
Alternative sequencei1344 – 13507GEETMSP → EHPLYSV in isoform 10. 1 PublicationVSP_012831
Alternative sequencei1351 – 1732382Missing in isoform 10. 1 PublicationVSP_012832Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ505025 mRNA. Translation: CAD43604.1.
AJ505026 mRNA. Translation: CAD43605.1.
AL159990, AL356318 Genomic DNA. Translation: CAI12193.1.
AL356318, AL159990 Genomic DNA. Translation: CAI96096.1.
AL159990
, AL161913, AL356318, AL358786, AL442645 Genomic DNA. Translation: CAM13096.1. Sequence problems.
AL356318
, AL159990, AL161913, AL358786, AL442645 Genomic DNA. Translation: CAM13169.1. Sequence problems.
AL358786
, AL159990, AL161913, AL356318, AL442645 Genomic DNA. Translation: CAM15782.1. Sequence problems.
AL442645
, AL159990, AL161913, AL356318, AL358786 Genomic DNA. Translation: CAM17596.1. Sequence problems.
AL161913
, AL159990, AL356318, AL358786, AL442645 Genomic DNA. Translation: CAM22746.1. Sequence problems.
AL160273 Genomic DNA. No translation available.
AL391819 Genomic DNA. No translation available.
AL592438 Genomic DNA. No translation available.
BC121821 mRNA. Translation: AAI21822.2.
BC134414 mRNA. Translation: AAI34415.1.
BC142972 mRNA. Translation: AAI42973.1.
AL136545 mRNA. Translation: CAB66480.2. Sequence problems.
AF536748 mRNA. Translation: AAO49153.1.
AF536749 mRNA. Translation: AAO49154.1.
AF536750 mRNA. Translation: AAO49155.1.
AF536751 mRNA. Translation: AAO49156.1.
AF536752 mRNA. Translation: AAO49157.1.
AF536753 mRNA. Translation: AAO49158.1.
AB099661 mRNA. Translation: BAC55102.1.
AB099662 mRNA. Translation: BAC55103.1.
AB099663 mRNA. Translation: BAC55104.1.
AB099664 mRNA. Translation: BAC55105.1.
AB099665 mRNA. Translation: BAC55106.1.
AB046836 mRNA. Translation: BAB13442.1.
CCDSiCCDS43835.1. [Q9HCF6-2]
CCDS6637.1. [Q9HCF6-12]
RefSeqiNP_001007472.2. NM_001007471.2. [Q9HCF6-2]
NP_996831.1. NM_206948.2. [Q9HCF6-12]
XP_005252275.1. XM_005252218.2. [Q9HCF6-11]
UniGeneiHs.47288.

Genome annotation databases

EnsembliENST00000361823; ENSP00000355395; ENSG00000083067. [Q9HCF6-12]
ENST00000377110; ENSP00000366314; ENSG00000083067. [Q9HCF6-2]
ENST00000377111; ENSP00000366315; ENSG00000083067. [Q9HCF6-10]
GeneIDi80036.
KEGGihsa:80036.
UCSCiuc004ahv.3. human. [Q9HCF6-8]
uc004ahw.3. human. [Q9HCF6-1]
uc004ahz.3. human. [Q9HCF6-5]
uc004aia.3. human. [Q9HCF6-2]
uc004aib.3. human. [Q9HCF6-4]
uc004aic.3. human. [Q9HCF6-10]
uc004aig.3. human. [Q9HCF6-12]

Polymorphism databases

DMDMi322510140.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ505025 mRNA. Translation: CAD43604.1 .
AJ505026 mRNA. Translation: CAD43605.1 .
AL159990 , AL356318 Genomic DNA. Translation: CAI12193.1 .
AL356318 , AL159990 Genomic DNA. Translation: CAI96096.1 .
AL159990
, AL161913 , AL356318 , AL358786 , AL442645 Genomic DNA. Translation: CAM13096.1 . Sequence problems.
AL356318
, AL159990 , AL161913 , AL358786 , AL442645 Genomic DNA. Translation: CAM13169.1 . Sequence problems.
AL358786
, AL159990 , AL161913 , AL356318 , AL442645 Genomic DNA. Translation: CAM15782.1 . Sequence problems.
AL442645
, AL159990 , AL161913 , AL356318 , AL358786 Genomic DNA. Translation: CAM17596.1 . Sequence problems.
AL161913
, AL159990 , AL356318 , AL358786 , AL442645 Genomic DNA. Translation: CAM22746.1 . Sequence problems.
AL160273 Genomic DNA. No translation available.
AL391819 Genomic DNA. No translation available.
AL592438 Genomic DNA. No translation available.
BC121821 mRNA. Translation: AAI21822.2 .
BC134414 mRNA. Translation: AAI34415.1 .
BC142972 mRNA. Translation: AAI42973.1 .
AL136545 mRNA. Translation: CAB66480.2 . Sequence problems.
AF536748 mRNA. Translation: AAO49153.1 .
AF536749 mRNA. Translation: AAO49154.1 .
AF536750 mRNA. Translation: AAO49155.1 .
AF536751 mRNA. Translation: AAO49156.1 .
AF536752 mRNA. Translation: AAO49157.1 .
AF536753 mRNA. Translation: AAO49158.1 .
AB099661 mRNA. Translation: BAC55102.1 .
AB099662 mRNA. Translation: BAC55103.1 .
AB099663 mRNA. Translation: BAC55104.1 .
AB099664 mRNA. Translation: BAC55105.1 .
AB099665 mRNA. Translation: BAC55106.1 .
AB046836 mRNA. Translation: BAB13442.1 .
CCDSi CCDS43835.1. [Q9HCF6-2 ]
CCDS6637.1. [Q9HCF6-12 ]
RefSeqi NP_001007472.2. NM_001007471.2. [Q9HCF6-2 ]
NP_996831.1. NM_206948.2. [Q9HCF6-12 ]
XP_005252275.1. XM_005252218.2. [Q9HCF6-11 ]
UniGenei Hs.47288.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123085. 2 interactions.
MINTi MINT-4713703.

Chemistry

GuidetoPHARMACOLOGYi 495.

Protein family/group databases

TCDBi 1.A.4.5.6. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

PhosphoSitei Q9HCF6.

Polymorphism databases

DMDMi 322510140.

Proteomic databases

MaxQBi Q9HCF6.
PaxDbi Q9HCF6.
PRIDEi Q9HCF6.

Protocols and materials databases

DNASUi 80036.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361823 ; ENSP00000355395 ; ENSG00000083067 . [Q9HCF6-12 ]
ENST00000377110 ; ENSP00000366314 ; ENSG00000083067 . [Q9HCF6-2 ]
ENST00000377111 ; ENSP00000366315 ; ENSG00000083067 . [Q9HCF6-10 ]
GeneIDi 80036.
KEGGi hsa:80036.
UCSCi uc004ahv.3. human. [Q9HCF6-8 ]
uc004ahw.3. human. [Q9HCF6-1 ]
uc004ahz.3. human. [Q9HCF6-5 ]
uc004aia.3. human. [Q9HCF6-2 ]
uc004aib.3. human. [Q9HCF6-4 ]
uc004aic.3. human. [Q9HCF6-10 ]
uc004aig.3. human. [Q9HCF6-12 ]

Organism-specific databases

CTDi 80036.
GeneCardsi GC09M073149.
HGNCi HGNC:17992. TRPM3.
MIMi 608961. gene.
neXtProti NX_Q9HCF6.
PharmGKBi PA38271.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253824.
GeneTreei ENSGT00760000119127.
HOGENOMi HOG000230920.
HOVERGENi HBG058254.
InParanoidi Q9HCF6.
KOi K04978.
OMAi KFWFYTL.
OrthoDBi EOG7NPFSC.
PhylomeDBi Q9HCF6.
TreeFami TF314204.

Enzyme and pathway databases

Reactomei REACT_169333. TRP channels.

Miscellaneous databases

ChiTaRSi TRPM3. human.
GeneWikii TRPM3.
GenomeRNAii 80036.
NextBioi 70216.
PROi Q9HCF6.
SOURCEi Search...

Gene expression databases

Bgeei Q9HCF6.
ExpressionAtlasi Q9HCF6. baseline and differential.
Genevestigatori Q9HCF6.

Family and domain databases

InterProi IPR005821. Ion_trans_dom.
IPR029583. TRPM3.
[Graphical view ]
PANTHERi PTHR13800:SF7. PTHR13800:SF7. 1 hit.
Pfami PF00520. Ion_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and functional characterization of the melastatin-related cation channel TRPM3."
    Grimm C., Kraft R., Sauerbruch S., Schultz G., Harteneck C.
    J. Biol. Chem. 278:21493-21501(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 10), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 12).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-324 (ISOFORM 11).
    Tissue: Amygdala.
  5. "Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3)."
    Lee N., Chen J., Sun L., Wu S., Gray K.R., Rich A., Huang M., Lin J.-H., Feder J.N., Janovitz E.B., Levesque P.C., Blanar M.A.
    J. Biol. Chem. 278:20890-20897(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 154-1732 (ISOFORMS 1; 2; 3; 4; 5 AND 6), VARIANT THR-1732, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "ProX human full-length cDNA cloning project."
    Okabayashi K., Hirano K., Sano M., Murahashi Y., Miyauchi A., Gonoi T.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 154-1732 (ISOFORMS 1; 2; 4; 7 AND 8), VARIANT THR-1732.
    Tissue: Brain.
  7. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 716-1732 (ISOFORMS 1/2/3/4/5/7/8), VARIANTS LYS-1717 AND THR-1732.
    Tissue: Brain.

Entry informationi

Entry nameiTRPM3_HUMAN
AccessioniPrimary (citable) accession number: Q9HCF6
Secondary accession number(s): A2A3F6
, A9Z1Y7, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01, Q9H0X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 115 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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