Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transient receptor potential cation channel subfamily M member 3

Gene

TRPM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000083067-MONOMER.
ReactomeiR-HSA-3295583. TRP channels.

Protein family/group databases

TCDBi1.A.4.5.6. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 3
Alternative name(s):
Long transient receptor potential channel 3
Short name:
LTrpC-3
Short name:
LTrpC3
Melastatin-2
Short name:
MLSN2
Gene namesi
Name:TRPM3
Synonyms:KIAA1616, LTRPC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:17992. TRPM3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 794CytoplasmicSequence analysisAdd BLAST770
Transmembranei795 – 815HelicalSequence analysisAdd BLAST21
Topological domaini816 – 897ExtracellularSequence analysisAdd BLAST82
Transmembranei898 – 918HelicalSequence analysisAdd BLAST21
Topological domaini919 – 964CytoplasmicSequence analysisAdd BLAST46
Transmembranei965 – 985HelicalSequence analysisAdd BLAST21
Topological domaini986 – 995ExtracellularSequence analysis10
Transmembranei996 – 1016HelicalSequence analysisAdd BLAST21
Topological domaini1017 – 1028CytoplasmicSequence analysisAdd BLAST12
Transmembranei1029 – 1049HelicalSequence analysisAdd BLAST21
Topological domaini1050 – 1116ExtracellularSequence analysisAdd BLAST67
Transmembranei1117 – 1137HelicalSequence analysisAdd BLAST21
Topological domaini1138 – 1732CytoplasmicSequence analysisAdd BLAST595

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80036.
OpenTargetsiENSG00000083067.
PharmGKBiPA38271.

Chemistry databases

GuidetoPHARMACOLOGYi495.

Polymorphism and mutation databases

BioMutaiTRPM3.
DMDMi322510140.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153281 – 1732Transient receptor potential cation channel subfamily M member 3Add BLAST1732

Proteomic databases

MaxQBiQ9HCF6.
PaxDbiQ9HCF6.
PeptideAtlasiQ9HCF6.
PRIDEiQ9HCF6.

PTM databases

iPTMnetiQ9HCF6.
PhosphoSitePlusiQ9HCF6.

Expressioni

Tissue specificityi

Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney.2 Publications

Gene expression databases

BgeeiENSG00000083067.
ExpressionAtlasiQ9HCF6. baseline and differential.
GenevisibleiQ9HCF6. HS.

Interactioni

Protein-protein interaction databases

BioGridi123085. 5 interactors.
MINTiMINT-4713703.
STRINGi9606.ENSP00000366314.

Structurei

3D structure databases

ProteinModelPortaliQ9HCF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1241 – 1301Sequence analysisAdd BLAST61

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
ENOG410XR5B. LUCA.
GeneTreeiENSGT00760000119127.
HOGENOMiHOG000230920.
HOVERGENiHBG058254.
InParanoidiQ9HCF6.
KOiK04978.
PhylomeDBiQ9HCF6.
TreeFamiTF314204.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029583. TRPM3.
IPR032415. TRPM_tetra.
[Graphical view]
PANTHERiPTHR13800:SF7. PTHR13800:SF7. 3 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF16519. TRPM_tetra. 1 hit.
[Graphical view]

Sequences (11)i

Sequence statusi: Complete.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCF6-1) [UniParc]FASTAAdd to basket
Also known as: TRPM3f

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEPWGTVYF LGIAQVFSFL FSWWNLEGVM NQADAPRPLN WTIRKLCHAA
60 70 80 90 100
FLPSVRLLKA QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT
110 120 130 140 150
PSISVLQNEK NESRLSRNDI QSEKWSISKH TQLSPTDAFG TIEFQGGGHS
160 170 180 190 200
NKAMYVRVSF DTKPDLLLHL MTKEWQLELP KLLISVHGGL QNFELQPKLK
210 220 230 240 250
QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS KSRGKICTIG
260 270 280 290 300
IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT
310 320 330 340 350
GKYGAEVKLR RQLEKHISLQ KINTRCLPFF SLDSRLFYSF WGSCQLDSVG
360 370 380 390 400
IGQGVPVVAL IVEGGPNVIS IVLEYLRDTP PVPVVVCDGS GRASDILAFG
410 420 430 440 450
HKYSEEGGLI NESLRDQLLV TIQKTFTYTR TQAQHLFIIL MECMKKKELI
460 470 480 490 500
TVFRMGSEGH QDIDLAILTA LLKGANASAP DQLSLALAWN RVDIARSQIF
510 520 530 540 550
IYGQQWPVGS LEQAMLDALV LDRVDFVKLL IENGVSMHRF LTISRLEELY
560 570 580 590 600
NTRHGPSNTL YHLVRDVKKG NLPPDYRISL IDIGLVIEYL MGGAYRCNYT
610 620 630 640 650
RKRFRTLYHN LFGPKRPKAL KLLGMEDDIP LRRGRKTTKK REEEVDIDLD
660 670 680 690 700
DPEINHFPFP FHELMVWAVL MKRQKMALFF WQHGEEAMAK ALVACKLCKA
710 720 730 740 750
MAHEASENDM VDDISQELNH NSRDFGQLAV ELLDQSYKQD EQLAMKLLTY
760 770 780 790 800
ELKNWSNATC LQLAVAAKHR DFIAHTCSQM LLTDMWMGRL RMRKNSGLKV
810 820 830 840 850
ILGILLPPSI LSLEFKNKDD MPYMSQAQEI HLQEKEAEEP EKPTKEKEEE
860 870 880 890 900
DMELTAMLGR NNGESSRKKD EEEVQSKHRL IPLGRKIYEF YNAPIVKFWF
910 920 930 940 950
YTLAYIGYLM LFNYIVLVKM ERWPSTQEWI VISYIFTLGI EKMREILMSE
960 970 980 990 1000
PGKLLQKVKV WLQEYWNVTD LIAILLFSVG MILRLQDQPF RSDGRVIYCV
1010 1020 1030 1040 1050
NIIYWYIRLL DIFGVNKYLG PYVMMIGKMM IDMMYFVIIM LVVLMSFGVA
1060 1070 1080 1090 1100
RQAILFPNEE PSWKLAKNIF YMPYWMIYGE VFADQIDPPC GQNETREDGK
1110 1120 1130 1140 1150
IIQLPPCKTG AWIVPAIMAC YLLVANILLV NLLIAVFNNT FFEVKSISNQ
1160 1170 1180 1190 1200
VWKFQRYQLI MTFHERPVLP PPLIIFSHMT MIFQHLCCRW RKHESDPDER
1210 1220 1230 1240 1250
DYGLKLFITD DELKKVHDFE EQCIEEYFRE KDDRFNSSND ERIRVTSERV
1260 1270 1280 1290 1300
ENMSMRLEEV NEREHSMKAS LQTVDIRLAQ LEDLIGRMAT ALERLTGLER
1310 1320 1330 1340 1350
AESNKIRSRT SSDCTDAAYI VRQSSFNSQE GNTFKLQESI DPAGEETMSP
1360 1370 1380 1390 1400
TSPTLMPRMR SHSFYSVNMK DKGGIEKLES IFKERSLSLH RATSSHSVAK
1410 1420 1430 1440 1450
EPKAPAAPAN TLAIVPDSRR PSSCIDIYVS AMDELHCDID PLDNSVNILG
1460 1470 1480 1490 1500
LGEPSFSTPV PSTAPSSSAY ATLAPTDRPP SRSIDFEDIT SMDTRSFSSD
1510 1520 1530 1540 1550
YTHLPECQNP WDSEPPMYHT IERSKSSRYL ATTPFLLEEA PIVKSHSFMF
1560 1570 1580 1590 1600
SPSRSYYANF GVPVKTAEYT SITDCIDTRC VNAPQAIADR AAFPGGLGDK
1610 1620 1630 1640 1650
VEDLTCCHPE REAELSHPSS DSEENEAKGR RATIAISSQE GDNSERTLSN
1660 1670 1680 1690 1700
NITVPKIERA NSYSAEEPSA PYAHTRKSFS ISDKLDRQRN TASLRNPFQR
1710 1720 1730
SKSSKPEGRG DSLSMRRLSR TSAFQSFESK HN
Length:1,732
Mass (Da):197,571
Last modified:February 8, 2011 - v4
Checksum:i0D6BE312C56646A4
GO
Isoform 2 (identifier: Q9HCF6-2) [UniParc]FASTAAdd to basket
Also known as: TRPM3a

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.

Show »
Length:1,707
Mass (Da):194,714
Checksum:i16522E65FD2FAA3F
GO
Isoform 3 (identifier: Q9HCF6-3) [UniParc]FASTAAdd to basket
Also known as: TRPM3b

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     569-569: K → KREYPGFGWIYFK

Show »
Length:1,719
Mass (Da):196,259
Checksum:i27EAFF76AFB0A46B
GO
Isoform 4 (identifier: Q9HCF6-4) [UniParc]FASTAAdd to basket
Also known as: TRPM3d

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     617-626: Missing.

Show »
Length:1,697
Mass (Da):193,632
Checksum:i144786F6D67B4F0B
GO
Isoform 5 (identifier: Q9HCF6-5) [UniParc]FASTAAdd to basket
Also known as: TRPM3e

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     569-569: K → KREYPGFGWIYFK
     617-626: Missing.

Show »
Length:1,709
Mass (Da):195,177
Checksum:iDA6133571BA70002
GO
Isoform 6 (identifier: Q9HCF6-6) [UniParc]FASTAAdd to basket
Also known as: TRPM3c

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     1088-1088: P → RKQVYDSHTPKSA

Show »
Length:1,719
Mass (Da):196,115
Checksum:i46BEADD398188191
GO
Isoform 7 (identifier: Q9HCF6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     617-626: Missing.

Show »
Length:1,722
Mass (Da):196,490
Checksum:iE30BDDE5FB3E061B
GO
Isoform 8 (identifier: Q9HCF6-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     535-552: Missing.
     617-626: Missing.

Show »
Length:1,679
Mass (Da):191,441
Checksum:iC90DF3FAF79D9637
GO
Isoform 10 (identifier: Q9HCF6-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     1344-1350: GEETMSP → EHPLYSV
     1351-1732: Missing.

Show »
Length:1,325
Mass (Da):152,656
Checksum:i837BEDE795F5E400
GO
Isoform 11 (identifier: Q9HCF6-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: MPEPWGTVYF...AFLPSVRLLK → MGKKWRDAAE...RSGLPSQQTP

Show »
Length:1,734
Mass (Da):197,679
Checksum:iD536EBCD7F526C10
GO
Isoform 12 (identifier: Q9HCF6-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     326-350: Missing.
     409-1732: Missing.

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):25,159
Checksum:i237AF35F9D6036F2
GO

Sequence cautioni

The sequence CAB66480 differs from that shown. Cloning artifact in C-terminus.Curated
The sequence CAM13096 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM13169 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM15782 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM17596 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM22746 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti335R → H in BAC55103 (Ref. 6) Curated1
Sequence conflicti695C → Y in BAC55106 (Ref. 6) Curated1
Sequence conflicti1032D → E in BAC55106 (Ref. 6) Curated1
Sequence conflicti1730K → Q in BAC55104 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0573051653T → I.Corresponds to variant rs13440436dbSNPEnsembl.1
Natural variantiVAR_0212571695R → Q.Corresponds to variant rs6560142dbSNPEnsembl.1
Natural variantiVAR_0618621717R → K.1 PublicationCorresponds to variant rs41287373dbSNPEnsembl.1
Natural variantiVAR_0573061732N → T.3 PublicationsCorresponds to variant rs17535963dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0435151 – 153Missing in isoform 12. 1 PublicationAdd BLAST153
Alternative sequenceiVSP_0391071 – 59MPEPW…VRLLK → MGKKWRDAAEMERGCSDRED NAESRRRSRSASRGRFAESW KRLSSKQGSTKRSGLPSQQT P in isoform 11. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_012826326 – 350Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 8, isoform 10 and isoform 12. 4 PublicationsAdd BLAST25
Alternative sequenceiVSP_043516409 – 1732Missing in isoform 12. 1 PublicationAdd BLAST1324
Alternative sequenceiVSP_012827535 – 552Missing in isoform 8. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_012828569K → KREYPGFGWIYFK in isoform 3 and isoform 5. 1 Publication1
Alternative sequenceiVSP_012829617 – 626Missing in isoform 4, isoform 5, isoform 7 and isoform 8. 2 Publications10
Alternative sequenceiVSP_0128301088P → RKQVYDSHTPKSA in isoform 6. 1 Publication1
Alternative sequenceiVSP_0128311344 – 1350GEETMSP → EHPLYSV in isoform 10. 1 Publication7
Alternative sequenceiVSP_0128321351 – 1732Missing in isoform 10. 1 PublicationAdd BLAST382

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ505025 mRNA. Translation: CAD43604.1.
AJ505026 mRNA. Translation: CAD43605.1.
AL159990, AL356318 Genomic DNA. Translation: CAI12193.1.
AL356318, AL159990 Genomic DNA. Translation: CAI96096.1.
AL159990
, AL161913, AL356318, AL358786, AL442645 Genomic DNA. Translation: CAM13096.1. Sequence problems.
AL356318
, AL159990, AL161913, AL358786, AL442645 Genomic DNA. Translation: CAM13169.1. Sequence problems.
AL358786
, AL159990, AL161913, AL356318, AL442645 Genomic DNA. Translation: CAM15782.1. Sequence problems.
AL442645
, AL159990, AL161913, AL356318, AL358786 Genomic DNA. Translation: CAM17596.1. Sequence problems.
AL161913
, AL159990, AL356318, AL358786, AL442645 Genomic DNA. Translation: CAM22746.1. Sequence problems.
AL160273 Genomic DNA. No translation available.
AL391819 Genomic DNA. No translation available.
AL592438 Genomic DNA. No translation available.
BC121821 mRNA. Translation: AAI21822.2.
BC134414 mRNA. Translation: AAI34415.1.
BC142972 mRNA. Translation: AAI42973.1.
AL136545 mRNA. Translation: CAB66480.2. Sequence problems.
AF536748 mRNA. Translation: AAO49153.1.
AF536749 mRNA. Translation: AAO49154.1.
AF536750 mRNA. Translation: AAO49155.1.
AF536751 mRNA. Translation: AAO49156.1.
AF536752 mRNA. Translation: AAO49157.1.
AF536753 mRNA. Translation: AAO49158.1.
AB099661 mRNA. Translation: BAC55102.1.
AB099662 mRNA. Translation: BAC55103.1.
AB099663 mRNA. Translation: BAC55104.1.
AB099664 mRNA. Translation: BAC55105.1.
AB099665 mRNA. Translation: BAC55106.1.
AB046836 mRNA. Translation: BAB13442.1.
CCDSiCCDS43835.1. [Q9HCF6-2]
CCDS6637.1. [Q9HCF6-12]
RefSeqiNP_001007472.2. NM_001007471.2. [Q9HCF6-2]
NP_996831.1. NM_206948.2. [Q9HCF6-12]
XP_011517340.1. XM_011519038.2. [Q9HCF6-1]
XP_011517341.1. XM_011519039.2. [Q9HCF6-7]
XP_011517343.1. XM_011519041.2. [Q9HCF6-3]
XP_011517346.1. XM_011519044.2. [Q9HCF6-5]
XP_011517348.1. XM_011519046.2. [Q9HCF6-4]
XP_011517349.1. XM_011519047.2. [Q9HCF6-10]
XP_016870631.1. XM_017015142.1. [Q9HCF6-11]
UniGeneiHs.47288.

Genome annotation databases

EnsembliENST00000361823; ENSP00000355395; ENSG00000083067. [Q9HCF6-12]
ENST00000377110; ENSP00000366314; ENSG00000083067. [Q9HCF6-2]
ENST00000377111; ENSP00000366315; ENSG00000083067. [Q9HCF6-10]
GeneIDi80036.
KEGGihsa:80036.
UCSCiuc004aic.4. human. [Q9HCF6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ505025 mRNA. Translation: CAD43604.1.
AJ505026 mRNA. Translation: CAD43605.1.
AL159990, AL356318 Genomic DNA. Translation: CAI12193.1.
AL356318, AL159990 Genomic DNA. Translation: CAI96096.1.
AL159990
, AL161913, AL356318, AL358786, AL442645 Genomic DNA. Translation: CAM13096.1. Sequence problems.
AL356318
, AL159990, AL161913, AL358786, AL442645 Genomic DNA. Translation: CAM13169.1. Sequence problems.
AL358786
, AL159990, AL161913, AL356318, AL442645 Genomic DNA. Translation: CAM15782.1. Sequence problems.
AL442645
, AL159990, AL161913, AL356318, AL358786 Genomic DNA. Translation: CAM17596.1. Sequence problems.
AL161913
, AL159990, AL356318, AL358786, AL442645 Genomic DNA. Translation: CAM22746.1. Sequence problems.
AL160273 Genomic DNA. No translation available.
AL391819 Genomic DNA. No translation available.
AL592438 Genomic DNA. No translation available.
BC121821 mRNA. Translation: AAI21822.2.
BC134414 mRNA. Translation: AAI34415.1.
BC142972 mRNA. Translation: AAI42973.1.
AL136545 mRNA. Translation: CAB66480.2. Sequence problems.
AF536748 mRNA. Translation: AAO49153.1.
AF536749 mRNA. Translation: AAO49154.1.
AF536750 mRNA. Translation: AAO49155.1.
AF536751 mRNA. Translation: AAO49156.1.
AF536752 mRNA. Translation: AAO49157.1.
AF536753 mRNA. Translation: AAO49158.1.
AB099661 mRNA. Translation: BAC55102.1.
AB099662 mRNA. Translation: BAC55103.1.
AB099663 mRNA. Translation: BAC55104.1.
AB099664 mRNA. Translation: BAC55105.1.
AB099665 mRNA. Translation: BAC55106.1.
AB046836 mRNA. Translation: BAB13442.1.
CCDSiCCDS43835.1. [Q9HCF6-2]
CCDS6637.1. [Q9HCF6-12]
RefSeqiNP_001007472.2. NM_001007471.2. [Q9HCF6-2]
NP_996831.1. NM_206948.2. [Q9HCF6-12]
XP_011517340.1. XM_011519038.2. [Q9HCF6-1]
XP_011517341.1. XM_011519039.2. [Q9HCF6-7]
XP_011517343.1. XM_011519041.2. [Q9HCF6-3]
XP_011517346.1. XM_011519044.2. [Q9HCF6-5]
XP_011517348.1. XM_011519046.2. [Q9HCF6-4]
XP_011517349.1. XM_011519047.2. [Q9HCF6-10]
XP_016870631.1. XM_017015142.1. [Q9HCF6-11]
UniGeneiHs.47288.

3D structure databases

ProteinModelPortaliQ9HCF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123085. 5 interactors.
MINTiMINT-4713703.
STRINGi9606.ENSP00000366314.

Chemistry databases

GuidetoPHARMACOLOGYi495.

Protein family/group databases

TCDBi1.A.4.5.6. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

iPTMnetiQ9HCF6.
PhosphoSitePlusiQ9HCF6.

Polymorphism and mutation databases

BioMutaiTRPM3.
DMDMi322510140.

Proteomic databases

MaxQBiQ9HCF6.
PaxDbiQ9HCF6.
PeptideAtlasiQ9HCF6.
PRIDEiQ9HCF6.

Protocols and materials databases

DNASUi80036.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361823; ENSP00000355395; ENSG00000083067. [Q9HCF6-12]
ENST00000377110; ENSP00000366314; ENSG00000083067. [Q9HCF6-2]
ENST00000377111; ENSP00000366315; ENSG00000083067. [Q9HCF6-10]
GeneIDi80036.
KEGGihsa:80036.
UCSCiuc004aic.4. human. [Q9HCF6-1]

Organism-specific databases

CTDi80036.
DisGeNETi80036.
GeneCardsiTRPM3.
HGNCiHGNC:17992. TRPM3.
MIMi608961. gene.
neXtProtiNX_Q9HCF6.
OpenTargetsiENSG00000083067.
PharmGKBiPA38271.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
ENOG410XR5B. LUCA.
GeneTreeiENSGT00760000119127.
HOGENOMiHOG000230920.
HOVERGENiHBG058254.
InParanoidiQ9HCF6.
KOiK04978.
PhylomeDBiQ9HCF6.
TreeFamiTF314204.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000083067-MONOMER.
ReactomeiR-HSA-3295583. TRP channels.

Miscellaneous databases

ChiTaRSiTRPM3. human.
GeneWikiiTRPM3.
GenomeRNAii80036.
PROiQ9HCF6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000083067.
ExpressionAtlasiQ9HCF6. baseline and differential.
GenevisibleiQ9HCF6. HS.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029583. TRPM3.
IPR032415. TRPM_tetra.
[Graphical view]
PANTHERiPTHR13800:SF7. PTHR13800:SF7. 3 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF16519. TRPM_tetra. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPM3_HUMAN
AccessioniPrimary (citable) accession number: Q9HCF6
Secondary accession number(s): A2A3F6
, A9Z1Y7, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01, Q9H0X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: February 8, 2011
Last modified: November 2, 2016
This is version 129 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.