Q9HCF6 (TRPM3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transient receptor potential cation channel subfamily M member 3

Alternative name(s):
Long transient receptor potential channel 3
Short name=LTrpC-3
Short name=LTrpC3
Melastatin-2
Short name=MLSN2

Gene names

Name:	TRPM3
Synonyms:	KIAA1616, LTRPC3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1732 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. Ref.1 Ref.5
Subcellular location	Membrane; Multi-pass membrane protein Ref.5.
Tissue specificity	Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. Ref.1 Ref.5
Sequence similarities	Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM3 sub-subfamily. [View classification]
Sequence caution	The sequence CAB66480.2 differs from that shown. Reason: Cloning artifact in C-terminus. The sequence CAM13096.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAM13169.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAM15782.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAM17596.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAM22746.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium channel activity Inferred from electronic annotation. Source: UniProtKB-KW cation channel activity Inferred from direct assay PubMed 15824111. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HCF6-1)

Also known as: TRPM3f;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HCF6-2)

Also known as: TRPM3a;

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.

Isoform 3 (identifier: Q9HCF6-3)

Also known as: TRPM3b;

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     569-569: K → KREYPGFGWIYFK

Isoform 4 (identifier: Q9HCF6-4)

Also known as: TRPM3d;

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     617-626: Missing.

Isoform 5 (identifier: Q9HCF6-5)

Also known as: TRPM3e;

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     569-569: K → KREYPGFGWIYFK
     617-626: Missing.

Isoform 6 (identifier: Q9HCF6-6)

Also known as: TRPM3c;

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     1088-1088: P → RKQVYDSHTPKSA

Isoform 7 (identifier: Q9HCF6-7)

The sequence of this isoform differs from the canonical sequence as follows:
     617-626: Missing.

Isoform 8 (identifier: Q9HCF6-8)

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     535-552: Missing.
     617-626: Missing.

Isoform 10 (identifier: Q9HCF6-10)

The sequence of this isoform differs from the canonical sequence as follows:
     326-350: Missing.
     1344-1350: GEETMSP → EHPLYSV
     1351-1732: Missing.

Isoform 11 (identifier: Q9HCF6-11)

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: MPEPWGTVYF...AFLPSVRLLK → MGKKWRDAAE...RSGLPSQQTP

Isoform 12 (identifier: Q9HCF6-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     326-350: Missing.
     409-1732: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1732	1732	Transient receptor potential cation channel subfamily M member 3		PRO_0000215328
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Topological domain	25 – 794	770	Cytoplasmic Potential
	Transmembrane	795 – 815	21	Helical; Potential
	Topological domain	816 – 897	82	Extracellular Potential
	Transmembrane	898 – 918	21	Helical; Potential
	Topological domain	919 – 964	46	Cytoplasmic Potential
	Transmembrane	965 – 985	21	Helical; Potential
	Topological domain	986 – 995	10	Extracellular Potential
	Transmembrane	996 – 1016	21	Helical; Potential
	Topological domain	1017 – 1028	12	Cytoplasmic Potential
	Transmembrane	1029 – 1049	21	Helical; Potential
	Topological domain	1050 – 1116	67	Extracellular Potential
	Transmembrane	1117 – 1137	21	Helical; Potential
	Topological domain	1138 – 1732	595	Cytoplasmic Potential
	Coiled coil	1241 – 1301	61	Potential
Natural variations
	Alternative sequence	1 – 153	153	Missing in isoform 12.		VSP_043515
	Alternative sequence	1 – 59	59	MPEPW…VRLLK → MGKKWRDAAEMERGCSDRED NAESRRRSRSASRGRFAESW KRLSSKQGSTKRSGLPSQQT P in isoform 11.		VSP_039107
	Alternative sequence	326 – 350	25	Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 8, isoform 10 and isoform 12.		VSP_012826
	Alternative sequence	409 – 1732	1324	Missing in isoform 12.		VSP_043516
	Alternative sequence	535 – 552	18	Missing in isoform 8.		VSP_012827
	Alternative sequence	569	1	K → KREYPGFGWIYFK in isoform 3 and isoform 5.		VSP_012828
	Alternative sequence	617 – 626	10	Missing in isoform 4, isoform 5, isoform 7 and isoform 8.		VSP_012829
	Alternative sequence	1088	1	P → RKQVYDSHTPKSA in isoform 6.		VSP_012830
	Alternative sequence	1344 – 1350	7	GEETMSP → EHPLYSV in isoform 10.		VSP_012831
	Alternative sequence	1351 – 1732	382	Missing in isoform 10.		VSP_012832
	Natural variant	1653	1	T → I. Corresponds to variant rs13440436 [ dbSNP | Ensembl ].		VAR_057305
	Natural variant	1695	1	R → Q. Corresponds to variant rs6560142 [ dbSNP | Ensembl ].		VAR_021257
	Natural variant	1717	1	R → K. Ref.7 Corresponds to variant rs41287373 [ dbSNP | Ensembl ].		VAR_061862
	Natural variant	1732	1	N → T. Ref.5 Ref.6 Ref.7 Corresponds to variant rs17535963 [ dbSNP | Ensembl ].		VAR_057306
Experimental info
	Sequence conflict	335	1	R → H in BAC55103. Ref.6
	Sequence conflict	695	1	C → Y in BAC55106. Ref.6
	Sequence conflict	1032	1	D → E in BAC55106. Ref.6
	Sequence conflict	1730	1	K → Q in BAC55104. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (TRPM3f) [UniParc]. Last modified February 8, 2011. Version 4. Checksum: 0D6BE312C56646A4	FASTA	1,732	197,571
	10 20 30 40 50 60 MPEPWGTVYF LGIAQVFSFL FSWWNLEGVM NQADAPRPLN WTIRKLCHAA FLPSVRLLKA 70 80 90 100 110 120 QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT PSISVLQNEK NESRLSRNDI 130 140 150 160 170 180 QSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSF DTKPDLLLHL MTKEWQLELP 190 200 210 220 230 240 KLLISVHGGL QNFELQPKLK QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS 250 260 270 280 290 300 KSRGKICTIG IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT 310 320 330 340 350 360 GKYGAEVKLR RQLEKHISLQ KINTRCLPFF SLDSRLFYSF WGSCQLDSVG IGQGVPVVAL 370 380 390 400 410 420 IVEGGPNVIS IVLEYLRDTP PVPVVVCDGS GRASDILAFG HKYSEEGGLI NESLRDQLLV 430 440 450 460 470 480 TIQKTFTYTR TQAQHLFIIL MECMKKKELI TVFRMGSEGH QDIDLAILTA LLKGANASAP 490 500 510 520 530 540 DQLSLALAWN RVDIARSQIF IYGQQWPVGS LEQAMLDALV LDRVDFVKLL IENGVSMHRF 550 560 570 580 590 600 LTISRLEELY NTRHGPSNTL YHLVRDVKKG NLPPDYRISL IDIGLVIEYL MGGAYRCNYT 610 620 630 640 650 660 RKRFRTLYHN LFGPKRPKAL KLLGMEDDIP LRRGRKTTKK REEEVDIDLD DPEINHFPFP 670 680 690 700 710 720 FHELMVWAVL MKRQKMALFF WQHGEEAMAK ALVACKLCKA MAHEASENDM VDDISQELNH 730 740 750 760 770 780 NSRDFGQLAV ELLDQSYKQD EQLAMKLLTY ELKNWSNATC LQLAVAAKHR DFIAHTCSQM 790 800 810 820 830 840 LLTDMWMGRL RMRKNSGLKV ILGILLPPSI LSLEFKNKDD MPYMSQAQEI HLQEKEAEEP 850 860 870 880 890 900 EKPTKEKEEE DMELTAMLGR NNGESSRKKD EEEVQSKHRL IPLGRKIYEF YNAPIVKFWF 910 920 930 940 950 960 YTLAYIGYLM LFNYIVLVKM ERWPSTQEWI VISYIFTLGI EKMREILMSE PGKLLQKVKV 970 980 990 1000 1010 1020 WLQEYWNVTD LIAILLFSVG MILRLQDQPF RSDGRVIYCV NIIYWYIRLL DIFGVNKYLG 1030 1040 1050 1060 1070 1080 PYVMMIGKMM IDMMYFVIIM LVVLMSFGVA RQAILFPNEE PSWKLAKNIF YMPYWMIYGE 1090 1100 1110 1120 1130 1140 VFADQIDPPC GQNETREDGK IIQLPPCKTG AWIVPAIMAC YLLVANILLV NLLIAVFNNT 1150 1160 1170 1180 1190 1200 FFEVKSISNQ VWKFQRYQLI MTFHERPVLP PPLIIFSHMT MIFQHLCCRW RKHESDPDER 1210 1220 1230 1240 1250 1260 DYGLKLFITD DELKKVHDFE EQCIEEYFRE KDDRFNSSND ERIRVTSERV ENMSMRLEEV 1270 1280 1290 1300 1310 1320 NEREHSMKAS LQTVDIRLAQ LEDLIGRMAT ALERLTGLER AESNKIRSRT SSDCTDAAYI 1330 1340 1350 1360 1370 1380 VRQSSFNSQE GNTFKLQESI DPAGEETMSP TSPTLMPRMR SHSFYSVNMK DKGGIEKLES 1390 1400 1410 1420 1430 1440 IFKERSLSLH RATSSHSVAK EPKAPAAPAN TLAIVPDSRR PSSCIDIYVS AMDELHCDID 1450 1460 1470 1480 1490 1500 PLDNSVNILG LGEPSFSTPV PSTAPSSSAY ATLAPTDRPP SRSIDFEDIT SMDTRSFSSD 1510 1520 1530 1540 1550 1560 YTHLPECQNP WDSEPPMYHT IERSKSSRYL ATTPFLLEEA PIVKSHSFMF SPSRSYYANF 1570 1580 1590 1600 1610 1620 GVPVKTAEYT SITDCIDTRC VNAPQAIADR AAFPGGLGDK VEDLTCCHPE REAELSHPSS 1630 1640 1650 1660 1670 1680 DSEENEAKGR RATIAISSQE GDNSERTLSN NITVPKIERA NSYSAEEPSA PYAHTRKSFS 1690 1700 1710 1720 1730 ISDKLDRQRN TASLRNPFQR SKSSKPEGRG DSLSMRRLSR TSAFQSFESK HN
	Isoform 2 (TRPM3a) [UniParc]. Checksum: 16522E65FD2FAA3F	FASTA	1,707	194,714
	10 20 30 40 50 60 MPEPWGTVYF LGIAQVFSFL FSWWNLEGVM NQADAPRPLN WTIRKLCHAA FLPSVRLLKA 70 80 90 100 110 120 QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT PSISVLQNEK NESRLSRNDI 130 140 150 160 170 180 QSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSF DTKPDLLLHL MTKEWQLELP 190 200 210 220 230 240 KLLISVHGGL QNFELQPKLK QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS 250 260 270 280 290 300 KSRGKICTIG IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT 310 320 330 340 350 360 GKYGAEVKLR RQLEKHISLQ KINTRIGQGV PVVALIVEGG PNVISIVLEY LRDTPPVPVV 370 380 390 400 410 420 VCDGSGRASD ILAFGHKYSE EGGLINESLR DQLLVTIQKT FTYTRTQAQH LFIILMECMK 430 440 450 460 470 480 KKELITVFRM GSEGHQDIDL AILTALLKGA NASAPDQLSL ALAWNRVDIA RSQIFIYGQQ 490 500 510 520 530 540 WPVGSLEQAM LDALVLDRVD FVKLLIENGV SMHRFLTISR LEELYNTRHG PSNTLYHLVR 550 560 570 580 590 600 DVKKGNLPPD YRISLIDIGL VIEYLMGGAY RCNYTRKRFR TLYHNLFGPK RPKALKLLGM 610 620 630 640 650 660 EDDIPLRRGR KTTKKREEEV DIDLDDPEIN HFPFPFHELM VWAVLMKRQK MALFFWQHGE 670 680 690 700 710 720 EAMAKALVAC KLCKAMAHEA SENDMVDDIS QELNHNSRDF GQLAVELLDQ SYKQDEQLAM 730 740 750 760 770 780 KLLTYELKNW SNATCLQLAV AAKHRDFIAH TCSQMLLTDM WMGRLRMRKN SGLKVILGIL 790 800 810 820 830 840 LPPSILSLEF KNKDDMPYMS QAQEIHLQEK EAEEPEKPTK EKEEEDMELT AMLGRNNGES 850 860 870 880 890 900 SRKKDEEEVQ SKHRLIPLGR KIYEFYNAPI VKFWFYTLAY IGYLMLFNYI VLVKMERWPS 910 920 930 940 950 960 TQEWIVISYI FTLGIEKMRE ILMSEPGKLL QKVKVWLQEY WNVTDLIAIL LFSVGMILRL 970 980 990 1000 1010 1020 QDQPFRSDGR VIYCVNIIYW YIRLLDIFGV NKYLGPYVMM IGKMMIDMMY FVIIMLVVLM 1030 1040 1050 1060 1070 1080 SFGVARQAIL FPNEEPSWKL AKNIFYMPYW MIYGEVFADQ IDPPCGQNET REDGKIIQLP 1090 1100 1110 1120 1130 1140 PCKTGAWIVP AIMACYLLVA NILLVNLLIA VFNNTFFEVK SISNQVWKFQ RYQLIMTFHE 1150 1160 1170 1180 1190 1200 RPVLPPPLII FSHMTMIFQH LCCRWRKHES DPDERDYGLK LFITDDELKK VHDFEEQCIE 1210 1220 1230 1240 1250 1260 EYFREKDDRF NSSNDERIRV TSERVENMSM RLEEVNEREH SMKASLQTVD IRLAQLEDLI 1270 1280 1290 1300 1310 1320 GRMATALERL TGLERAESNK IRSRTSSDCT DAAYIVRQSS FNSQEGNTFK LQESIDPAGE 1330 1340 1350 1360 1370 1380 ETMSPTSPTL MPRMRSHSFY SVNMKDKGGI EKLESIFKER SLSLHRATSS HSVAKEPKAP 1390 1400 1410 1420 1430 1440 AAPANTLAIV PDSRRPSSCI DIYVSAMDEL HCDIDPLDNS VNILGLGEPS FSTPVPSTAP 1450 1460 1470 1480 1490 1500 SSSAYATLAP TDRPPSRSID FEDITSMDTR SFSSDYTHLP ECQNPWDSEP PMYHTIERSK 1510 1520 1530 1540 1550 1560 SSRYLATTPF LLEEAPIVKS HSFMFSPSRS YYANFGVPVK TAEYTSITDC IDTRCVNAPQ 1570 1580 1590 1600 1610 1620 AIADRAAFPG GLGDKVEDLT CCHPEREAEL SHPSSDSEEN EAKGRRATIA ISSQEGDNSE 1630 1640 1650 1660 1670 1680 RTLSNNITVP KIERANSYSA EEPSAPYAHT RKSFSISDKL DRQRNTASLR NPFQRSKSSK 1690 1700 PEGRGDSLSM RRLSRTSAFQ SFESKHN
	Isoform 3 (TRPM3b) [UniParc]. Checksum: 27EAFF76AFB0A46B	FASTA	1,719	196,259
	10 20 30 40 50 60 MPEPWGTVYF LGIAQVFSFL FSWWNLEGVM NQADAPRPLN WTIRKLCHAA FLPSVRLLKA 70 80 90 100 110 120 QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT PSISVLQNEK NESRLSRNDI 130 140 150 160 170 180 QSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSF DTKPDLLLHL MTKEWQLELP 190 200 210 220 230 240 KLLISVHGGL QNFELQPKLK QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS 250 260 270 280 290 300 KSRGKICTIG IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT 310 320 330 340 350 360 GKYGAEVKLR RQLEKHISLQ KINTRIGQGV PVVALIVEGG PNVISIVLEY LRDTPPVPVV 370 380 390 400 410 420 VCDGSGRASD ILAFGHKYSE EGGLINESLR DQLLVTIQKT FTYTRTQAQH LFIILMECMK 430 440 450 460 470 480 KKELITVFRM GSEGHQDIDL AILTALLKGA NASAPDQLSL ALAWNRVDIA RSQIFIYGQQ 490 500 510 520 530 540 WPVGSLEQAM LDALVLDRVD FVKLLIENGV SMHRFLTISR LEELYNTRHG PSNTLYHLVR 550 560 570 580 590 600 DVKKREYPGF GWIYFKGNLP PDYRISLIDI GLVIEYLMGG AYRCNYTRKR FRTLYHNLFG 610 620 630 640 650 660 PKRPKALKLL GMEDDIPLRR GRKTTKKREE EVDIDLDDPE INHFPFPFHE LMVWAVLMKR 670 680 690 700 710 720 QKMALFFWQH GEEAMAKALV ACKLCKAMAH EASENDMVDD ISQELNHNSR DFGQLAVELL 730 740 750 760 770 780 DQSYKQDEQL AMKLLTYELK NWSNATCLQL AVAAKHRDFI AHTCSQMLLT DMWMGRLRMR 790 800 810 820 830 840 KNSGLKVILG ILLPPSILSL EFKNKDDMPY MSQAQEIHLQ EKEAEEPEKP TKEKEEEDME 850 860 870 880 890 900 LTAMLGRNNG ESSRKKDEEE VQSKHRLIPL GRKIYEFYNA PIVKFWFYTL AYIGYLMLFN 910 920 930 940 950 960 YIVLVKMERW PSTQEWIVIS YIFTLGIEKM REILMSEPGK LLQKVKVWLQ EYWNVTDLIA 970 980 990 1000 1010 1020 ILLFSVGMIL RLQDQPFRSD GRVIYCVNII YWYIRLLDIF GVNKYLGPYV MMIGKMMIDM 1030 1040 1050 1060 1070 1080 MYFVIIMLVV LMSFGVARQA ILFPNEEPSW KLAKNIFYMP YWMIYGEVFA DQIDPPCGQN 1090 1100 1110 1120 1130 1140 ETREDGKIIQ LPPCKTGAWI VPAIMACYLL VANILLVNLL IAVFNNTFFE VKSISNQVWK 1150 1160 1170 1180 1190 1200 FQRYQLIMTF HERPVLPPPL IIFSHMTMIF QHLCCRWRKH ESDPDERDYG LKLFITDDEL 1210 1220 1230 1240 1250 1260 KKVHDFEEQC IEEYFREKDD RFNSSNDERI RVTSERVENM SMRLEEVNER EHSMKASLQT 1270 1280 1290 1300 1310 1320 VDIRLAQLED LIGRMATALE RLTGLERAES NKIRSRTSSD CTDAAYIVRQ SSFNSQEGNT 1330 1340 1350 1360 1370 1380 FKLQESIDPA GEETMSPTSP TLMPRMRSHS FYSVNMKDKG GIEKLESIFK ERSLSLHRAT 1390 1400 1410 1420 1430 1440 SSHSVAKEPK APAAPANTLA IVPDSRRPSS CIDIYVSAMD ELHCDIDPLD NSVNILGLGE 1450 1460 1470 1480 1490 1500 PSFSTPVPST APSSSAYATL APTDRPPSRS IDFEDITSMD TRSFSSDYTH LPECQNPWDS 1510 1520 1530 1540 1550 1560 EPPMYHTIER SKSSRYLATT PFLLEEAPIV KSHSFMFSPS RSYYANFGVP VKTAEYTSIT 1570 1580 1590 1600 1610 1620 DCIDTRCVNA PQAIADRAAF PGGLGDKVED LTCCHPEREA ELSHPSSDSE ENEAKGRRAT 1630 1640 1650 1660 1670 1680 IAISSQEGDN SERTLSNNIT VPKIERANSY SAEEPSAPYA HTRKSFSISD KLDRQRNTAS 1690 1700 1710 LRNPFQRSKS SKPEGRGDSL SMRRLSRTSA FQSFESKHN
	Isoform 4 (TRPM3d) [UniParc]. Checksum: 144786F6D67B4F0B	FASTA	1,697	193,632
	10 20 30 40 50 60 MPEPWGTVYF LGIAQVFSFL FSWWNLEGVM NQADAPRPLN WTIRKLCHAA FLPSVRLLKA 70 80 90 100 110 120 QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT PSISVLQNEK NESRLSRNDI 130 140 150 160 170 180 QSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSF DTKPDLLLHL MTKEWQLELP 190 200 210 220 230 240 KLLISVHGGL QNFELQPKLK QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS 250 260 270 280 290 300 KSRGKICTIG IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT 310 320 330 340 350 360 GKYGAEVKLR RQLEKHISLQ KINTRIGQGV PVVALIVEGG PNVISIVLEY LRDTPPVPVV 370 380 390 400 410 420 VCDGSGRASD ILAFGHKYSE EGGLINESLR DQLLVTIQKT FTYTRTQAQH LFIILMECMK 430 440 450 460 470 480 KKELITVFRM GSEGHQDIDL AILTALLKGA NASAPDQLSL ALAWNRVDIA RSQIFIYGQQ 490 500 510 520 530 540 WPVGSLEQAM LDALVLDRVD FVKLLIENGV SMHRFLTISR LEELYNTRHG PSNTLYHLVR 550 560 570 580 590 600 DVKKGNLPPD YRISLIDIGL VIEYLMGGAY RCNYTRKRFR TLYHNLFGPK RDDIPLRRGR 610 620 630 640 650 660 KTTKKREEEV DIDLDDPEIN HFPFPFHELM VWAVLMKRQK MALFFWQHGE EAMAKALVAC 670 680 690 700 710 720 KLCKAMAHEA SENDMVDDIS QELNHNSRDF GQLAVELLDQ SYKQDEQLAM KLLTYELKNW 730 740 750 760 770 780 SNATCLQLAV AAKHRDFIAH TCSQMLLTDM WMGRLRMRKN SGLKVILGIL LPPSILSLEF 790 800 810 820 830 840 KNKDDMPYMS QAQEIHLQEK EAEEPEKPTK EKEEEDMELT AMLGRNNGES SRKKDEEEVQ 850 860 870 880 890 900 SKHRLIPLGR KIYEFYNAPI VKFWFYTLAY IGYLMLFNYI VLVKMERWPS TQEWIVISYI 910 920 930 940 950 960 FTLGIEKMRE ILMSEPGKLL QKVKVWLQEY WNVTDLIAIL LFSVGMILRL QDQPFRSDGR 970 980 990 1000 1010 1020 VIYCVNIIYW YIRLLDIFGV NKYLGPYVMM IGKMMIDMMY FVIIMLVVLM SFGVARQAIL 1030 1040 1050 1060 1070 1080 FPNEEPSWKL AKNIFYMPYW MIYGEVFADQ IDPPCGQNET REDGKIIQLP PCKTGAWIVP 1090 1100 1110 1120 1130 1140 AIMACYLLVA NILLVNLLIA VFNNTFFEVK SISNQVWKFQ RYQLIMTFHE RPVLPPPLII 1150 1160 1170 1180 1190 1200 FSHMTMIFQH LCCRWRKHES DPDERDYGLK LFITDDELKK VHDFEEQCIE EYFREKDDRF 1210 1220 1230 1240 1250 1260 NSSNDERIRV TSERVENMSM RLEEVNEREH SMKASLQTVD IRLAQLEDLI GRMATALERL 1270 1280 1290 1300 1310 1320 TGLERAESNK IRSRTSSDCT DAAYIVRQSS FNSQEGNTFK LQESIDPAGE ETMSPTSPTL 1330 1340 1350 1360 1370 1380 MPRMRSHSFY SVNMKDKGGI EKLESIFKER SLSLHRATSS HSVAKEPKAP AAPANTLAIV 1390 1400 1410 1420 1430 1440 PDSRRPSSCI DIYVSAMDEL HCDIDPLDNS VNILGLGEPS FSTPVPSTAP SSSAYATLAP 1450 1460 1470 1480 1490 1500 TDRPPSRSID FEDITSMDTR SFSSDYTHLP ECQNPWDSEP PMYHTIERSK SSRYLATTPF 1510 1520 1530 1540 1550 1560 LLEEAPIVKS HSFMFSPSRS YYANFGVPVK TAEYTSITDC IDTRCVNAPQ AIADRAAFPG 1570 1580 1590 1600 1610 1620 GLGDKVEDLT CCHPEREAEL SHPSSDSEEN EAKGRRATIA ISSQEGDNSE RTLSNNITVP 1630 1640 1650 1660 1670 1680 KIERANSYSA EEPSAPYAHT RKSFSISDKL DRQRNTASLR NPFQRSKSSK PEGRGDSLSM 1690 RRLSRTSAFQ SFESKHN
	Isoform 5 (TRPM3e) [UniParc]. Checksum: DA6133571BA70002	FASTA	1,709	195,177
	10 20 30 40 50 60 MPEPWGTVYF LGIAQVFSFL FSWWNLEGVM NQADAPRPLN WTIRKLCHAA FLPSVRLLKA 70 80 90 100 110 120 QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT PSISVLQNEK NESRLSRNDI 130 140 150 160 170 180 QSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSF DTKPDLLLHL MTKEWQLELP 190 200 210 220 230 240 KLLISVHGGL QNFELQPKLK QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS 250 260 270 280 290 300 KSRGKICTIG IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT 310 320 330 340 350 360 GKYGAEVKLR RQLEKHISLQ KINTRIGQGV PVVALIVEGG PNVISIVLEY LRDTPPVPVV 370 380 390 400 410 420 VCDGSGRASD ILAFGHKYSE EGGLINESLR DQLLVTIQKT FTYTRTQAQH LFIILMECMK 430 440 450 460 470 480 KKELITVFRM GSEGHQDIDL AILTALLKGA NASAPDQLSL ALAWNRVDIA RSQIFIYGQQ 490 500 510 520 530 540 WPVGSLEQAM LDALVLDRVD FVKLLIENGV SMHRFLTISR LEELYNTRHG PSNTLYHLVR 550 560 570 580 590 600 DVKKREYPGF GWIYFKGNLP PDYRISLIDI GLVIEYLMGG AYRCNYTRKR FRTLYHNLFG 610 620 630 640 650 660 PKRDDIPLRR GRKTTKKREE EVDIDLDDPE INHFPFPFHE LMVWAVLMKR QKMALFFWQH 670 680 690 700 710 720 GEEAMAKALV ACKLCKAMAH EASENDMVDD ISQELNHNSR DFGQLAVELL DQSYKQDEQL 730 740 750 760 770 780 AMKLLTYELK NWSNATCLQL AVAAKHRDFI AHTCSQMLLT DMWMGRLRMR KNSGLKVILG 790 800 810 820 830 840 ILLPPSILSL EFKNKDDMPY MSQAQEIHLQ EKEAEEPEKP TKEKEEEDME LTAMLGRNNG 850 860 870 880 890 900 ESSRKKDEEE VQSKHRLIPL GRKIYEFYNA PIVKFWFYTL AYIGYLMLFN YIVLVKMERW 910 920 930 940 950 960 PSTQEWIVIS YIFTLGIEKM REILMSEPGK LLQKVKVWLQ EYWNVTDLIA ILLFSVGMIL 970 980 990 1000 1010 1020 RLQDQPFRSD GRVIYCVNII YWYIRLLDIF GVNKYLGPYV MMIGKMMIDM MYFVIIMLVV 1030 1040 1050 1060 1070 1080 LMSFGVARQA ILFPNEEPSW KLAKNIFYMP YWMIYGEVFA DQIDPPCGQN ETREDGKIIQ 1090 1100 1110 1120 1130 1140 LPPCKTGAWI VPAIMACYLL VANILLVNLL IAVFNNTFFE VKSISNQVWK FQRYQLIMTF 1150 1160 1170 1180 1190 1200 HERPVLPPPL IIFSHMTMIF QHLCCRWRKH ESDPDERDYG LKLFITDDEL KKVHDFEEQC 1210 1220 1230 1240 1250 1260 IEEYFREKDD RFNSSNDERI RVTSERVENM SMRLEEVNER EHSMKASLQT VDIRLAQLED 1270 1280 1290 1300 1310 1320 LIGRMATALE RLTGLERAES NKIRSRTSSD CTDAAYIVRQ SSFNSQEGNT FKLQESIDPA 1330 1340 1350 1360 1370 1380 GEETMSPTSP TLMPRMRSHS FYSVNMKDKG GIEKLESIFK ERSLSLHRAT SSHSVAKEPK 1390 1400 1410 1420 1430 1440 APAAPANTLA IVPDSRRPSS CIDIYVSAMD ELHCDIDPLD NSVNILGLGE PSFSTPVPST 1450 1460 1470 1480 1490 1500 APSSSAYATL APTDRPPSRS IDFEDITSMD TRSFSSDYTH LPECQNPWDS EPPMYHTIER 1510 1520 1530 1540 1550 1560 SKSSRYLATT PFLLEEAPIV KSHSFMFSPS RSYYANFGVP VKTAEYTSIT DCIDTRCVNA 1570 1580 1590 1600 1610 1620 PQAIADRAAF PGGLGDKVED LTCCHPEREA ELSHPSSDSE ENEAKGRRAT IAISSQEGDN 1630 1640 1650 1660 1670 1680 SERTLSNNIT VPKIERANSY SAEEPSAPYA HTRKSFSISD KLDRQRNTAS LRNPFQRSKS 1690 1700 SKPEGRGDSL SMRRLSRTSA FQSFESKHN
	Isoform 6 (TRPM3c) [UniParc]. Checksum: 46BEADD398188191	FASTA	1,719	196,115
	10 20 30 40 50 60 MPEPWGTVYF LGIAQVFSFL FSWWNLEGVM NQADAPRPLN WTIRKLCHAA FLPSVRLLKA 70 80 90 100 110 120 QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT PSISVLQNEK NESRLSRNDI 130 140 150 160 170 180 QSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSF DTKPDLLLHL MTKEWQLELP 190 200 210 220 230 240 KLLISVHGGL QNFELQPKLK QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS 250 260 270 280 290 300 KSRGKICTIG IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT 310 320 330 340 350 360 GKYGAEVKLR RQLEKHISLQ KINTRIGQGV PVVALIVEGG PNVISIVLEY LRDTPPVPVV 370 380 390 400 410 420 VCDGSGRASD ILAFGHKYSE EGGLINESLR DQLLVTIQKT FTYTRTQAQH LFIILMECMK 430 440 450 460 470 480 KKELITVFRM GSEGHQDIDL AILTALLKGA NASAPDQLSL ALAWNRVDIA RSQIFIYGQQ 490 500 510 520 530 540 WPVGSLEQAM LDALVLDRVD FVKLLIENGV SMHRFLTISR LEELYNTRHG PSNTLYHLVR 550 560 570 580 590 600 DVKKGNLPPD YRISLIDIGL VIEYLMGGAY RCNYTRKRFR TLYHNLFGPK RPKALKLLGM 610 620 630 640 650 660 EDDIPLRRGR KTTKKREEEV DIDLDDPEIN HFPFPFHELM VWAVLMKRQK MALFFWQHGE 670 680 690 700 710 720 EAMAKALVAC KLCKAMAHEA SENDMVDDIS QELNHNSRDF GQLAVELLDQ SYKQDEQLAM 730 740 750 760 770 780 KLLTYELKNW SNATCLQLAV AAKHRDFIAH TCSQMLLTDM WMGRLRMRKN SGLKVILGIL 790 800 810 820 830 840 LPPSILSLEF KNKDDMPYMS QAQEIHLQEK EAEEPEKPTK EKEEEDMELT AMLGRNNGES 850 860 870 880 890 900 SRKKDEEEVQ SKHRLIPLGR KIYEFYNAPI VKFWFYTLAY IGYLMLFNYI VLVKMERWPS 910 920 930 940 950 960 TQEWIVISYI FTLGIEKMRE ILMSEPGKLL QKVKVWLQEY WNVTDLIAIL LFSVGMILRL 970 980 990 1000 1010 1020 QDQPFRSDGR VIYCVNIIYW YIRLLDIFGV NKYLGPYVMM IGKMMIDMMY FVIIMLVVLM 1030 1040 1050 1060 1070 1080 SFGVARQAIL FPNEEPSWKL AKNIFYMPYW MIYGEVFADQ IDRKQVYDSH TPKSAPCGQN 1090 1100 1110 1120 1130 1140 ETREDGKIIQ LPPCKTGAWI VPAIMACYLL VANILLVNLL IAVFNNTFFE VKSISNQVWK 1150 1160 1170 1180 1190 1200 FQRYQLIMTF HERPVLPPPL IIFSHMTMIF QHLCCRWRKH ESDPDERDYG LKLFITDDEL 1210 1220 1230 1240 1250 1260 KKVHDFEEQC IEEYFREKDD RFNSSNDERI RVTSERVENM SMRLEEVNER EHSMKASLQT 1270 1280 1290 1300 1310 1320 VDIRLAQLED LIGRMATALE RLTGLERAES NKIRSRTSSD CTDAAYIVRQ SSFNSQEGNT 1330 1340 1350 1360 1370 1380 FKLQESIDPA GEETMSPTSP TLMPRMRSHS FYSVNMKDKG GIEKLESIFK ERSLSLHRAT 1390 1400 1410 1420 1430 1440 SSHSVAKEPK APAAPANTLA IVPDSRRPSS CIDIYVSAMD ELHCDIDPLD NSVNILGLGE 1450 1460 1470 1480 1490 1500 PSFSTPVPST APSSSAYATL APTDRPPSRS IDFEDITSMD TRSFSSDYTH LPECQNPWDS 1510 1520 1530 1540 1550 1560 EPPMYHTIER SKSSRYLATT PFLLEEAPIV KSHSFMFSPS RSYYANFGVP VKTAEYTSIT 1570 1580 1590 1600 1610 1620 DCIDTRCVNA PQAIADRAAF PGGLGDKVED LTCCHPEREA ELSHPSSDSE ENEAKGRRAT 1630 1640 1650 1660 1670 1680 IAISSQEGDN SERTLSNNIT VPKIERANSY SAEEPSAPYA HTRKSFSISD KLDRQRNTAS 1690 1700 1710 LRNPFQRSKS SKPEGRGDSL SMRRLSRTSA FQSFESKHN
	Isoform 7 [UniParc]. Checksum: E30BDDE5FB3E061B	FASTA	1,722	196,490
	10 20 30 40 50 60 MPEPWGTVYF LGIAQVFSFL FSWWNLEGVM NQADAPRPLN WTIRKLCHAA FLPSVRLLKA 70 80 90 100 110 120 QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT PSISVLQNEK NESRLSRNDI 130 140 150 160 170 180 QSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSF DTKPDLLLHL MTKEWQLELP 190 200 210 220 230 240 KLLISVHGGL QNFELQPKLK QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS 250 260 270 280 290 300 KSRGKICTIG IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT 310 320 330 340 350 360 GKYGAEVKLR RQLEKHISLQ KINTRCLPFF SLDSRLFYSF WGSCQLDSVG IGQGVPVVAL 370 380 390 400 410 420 IVEGGPNVIS IVLEYLRDTP PVPVVVCDGS GRASDILAFG HKYSEEGGLI NESLRDQLLV 430 440 450 460 470 480 TIQKTFTYTR TQAQHLFIIL MECMKKKELI TVFRMGSEGH QDIDLAILTA LLKGANASAP 490 500 510 520 530 540 DQLSLALAWN RVDIARSQIF IYGQQWPVGS LEQAMLDALV LDRVDFVKLL IENGVSMHRF 550 560 570 580 590 600 LTISRLEELY NTRHGPSNTL YHLVRDVKKG NLPPDYRISL IDIGLVIEYL MGGAYRCNYT 610 620 630 640 650 660 RKRFRTLYHN LFGPKRDDIP LRRGRKTTKK REEEVDIDLD DPEINHFPFP FHELMVWAVL 670 680 690 700 710 720 MKRQKMALFF WQHGEEAMAK ALVACKLCKA MAHEASENDM VDDISQELNH NSRDFGQLAV 730 740 750 760 770 780 ELLDQSYKQD EQLAMKLLTY ELKNWSNATC LQLAVAAKHR DFIAHTCSQM LLTDMWMGRL 790 800 810 820 830 840 RMRKNSGLKV ILGILLPPSI LSLEFKNKDD MPYMSQAQEI HLQEKEAEEP EKPTKEKEEE 850 860 870 880 890 900 DMELTAMLGR NNGESSRKKD EEEVQSKHRL IPLGRKIYEF YNAPIVKFWF YTLAYIGYLM 910 920 930 940 950 960 LFNYIVLVKM ERWPSTQEWI VISYIFTLGI EKMREILMSE PGKLLQKVKV WLQEYWNVTD 970 980 990 1000 1010 1020 LIAILLFSVG MILRLQDQPF RSDGRVIYCV NIIYWYIRLL DIFGVNKYLG PYVMMIGKMM 1030 1040 1050 1060 1070 1080 IDMMYFVIIM LVVLMSFGVA RQAILFPNEE PSWKLAKNIF YMPYWMIYGE VFADQIDPPC 1090 1100 1110 1120 1130 1140 GQNETREDGK IIQLPPCKTG AWIVPAIMAC YLLVANILLV NLLIAVFNNT FFEVKSISNQ 1150 1160 1170 1180 1190 1200 VWKFQRYQLI MTFHERPVLP PPLIIFSHMT MIFQHLCCRW RKHESDPDER DYGLKLFITD 1210 1220 1230 1240 1250 1260 DELKKVHDFE EQCIEEYFRE KDDRFNSSND ERIRVTSERV ENMSMRLEEV NEREHSMKAS 1270 1280 1290 1300 1310 1320 LQTVDIRLAQ LEDLIGRMAT ALERLTGLER AESNKIRSRT SSDCTDAAYI VRQSSFNSQE 1330 1340 1350 1360 1370 1380 GNTFKLQESI DPAGEETMSP TSPTLMPRMR SHSFYSVNMK DKGGIEKLES IFKERSLSLH 1390 1400 1410 1420 1430 1440 RATSSHSVAK EPKAPAAPAN TLAIVPDSRR PSSCIDIYVS AMDELHCDID PLDNSVNILG 1450 1460 1470 1480 1490 1500 LGEPSFSTPV PSTAPSSSAY ATLAPTDRPP SRSIDFEDIT SMDTRSFSSD YTHLPECQNP 1510 1520 1530 1540 1550 1560 WDSEPPMYHT IERSKSSRYL ATTPFLLEEA PIVKSHSFMF SPSRSYYANF GVPVKTAEYT 1570 1580 1590 1600 1610 1620 SITDCIDTRC VNAPQAIADR AAFPGGLGDK VEDLTCCHPE REAELSHPSS DSEENEAKGR 1630 1640 1650 1660 1670 1680 RATIAISSQE GDNSERTLSN NITVPKIERA NSYSAEEPSA PYAHTRKSFS ISDKLDRQRN 1690 1700 1710 1720 TASLRNPFQR SKSSKPEGRG DSLSMRRLSR TSAFQSFESK HN
	Isoform 8 [UniParc]. Checksum: C90DF3FAF79D9637	FASTA	1,679	191,441
	10 20 30 40 50 60 MPEPWGTVYF LGIAQVFSFL FSWWNLEGVM NQADAPRPLN WTIRKLCHAA FLPSVRLLKA 70 80 90 100 110 120 QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT PSISVLQNEK NESRLSRNDI 130 140 150 160 170 180 QSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSF DTKPDLLLHL MTKEWQLELP 190 200 210 220 230 240 KLLISVHGGL QNFELQPKLK QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS 250 260 270 280 290 300 KSRGKICTIG IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT 310 320 330 340 350 360 GKYGAEVKLR RQLEKHISLQ KINTRIGQGV PVVALIVEGG PNVISIVLEY LRDTPPVPVV 370 380 390 400 410 420 VCDGSGRASD ILAFGHKYSE EGGLINESLR DQLLVTIQKT FTYTRTQAQH LFIILMECMK 430 440 450 460 470 480 KKELITVFRM GSEGHQDIDL AILTALLKGA NASAPDQLSL ALAWNRVDIA RSQIFIYGQQ 490 500 510 520 530 540 WPVGSLEQAM LDALVLDRVD FVKLLIENGR HGPSNTLYHL VRDVKKGNLP PDYRISLIDI 550 560 570 580 590 600 GLVIEYLMGG AYRCNYTRKR FRTLYHNLFG PKRDDIPLRR GRKTTKKREE EVDIDLDDPE 610 620 630 640 650 660 INHFPFPFHE LMVWAVLMKR QKMALFFWQH GEEAMAKALV ACKLCKAMAH EASENDMVDD 670 680 690 700 710 720 ISQELNHNSR DFGQLAVELL DQSYKQDEQL AMKLLTYELK NWSNATCLQL AVAAKHRDFI 730 740 750 760 770 780 AHTCSQMLLT DMWMGRLRMR KNSGLKVILG ILLPPSILSL EFKNKDDMPY MSQAQEIHLQ 790 800 810 820 830 840 EKEAEEPEKP TKEKEEEDME LTAMLGRNNG ESSRKKDEEE VQSKHRLIPL GRKIYEFYNA 850 860 870 880 890 900 PIVKFWFYTL AYIGYLMLFN YIVLVKMERW PSTQEWIVIS YIFTLGIEKM REILMSEPGK 910 920 930 940 950 960 LLQKVKVWLQ EYWNVTDLIA ILLFSVGMIL RLQDQPFRSD GRVIYCVNII YWYIRLLDIF 970 980 990 1000 1010 1020 GVNKYLGPYV MMIGKMMIDM MYFVIIMLVV LMSFGVARQA ILFPNEEPSW KLAKNIFYMP 1030 1040 1050 1060 1070 1080 YWMIYGEVFA DQIDPPCGQN ETREDGKIIQ LPPCKTGAWI VPAIMACYLL VANILLVNLL 1090 1100 1110 1120 1130 1140 IAVFNNTFFE VKSISNQVWK FQRYQLIMTF HERPVLPPPL IIFSHMTMIF QHLCCRWRKH 1150 1160 1170 1180 1190 1200 ESDPDERDYG LKLFITDDEL KKVHDFEEQC IEEYFREKDD RFNSSNDERI RVTSERVENM 1210 1220 1230 1240 1250 1260 SMRLEEVNER EHSMKASLQT VDIRLAQLED LIGRMATALE RLTGLERAES NKIRSRTSSD 1270 1280 1290 1300 1310 1320 CTDAAYIVRQ SSFNSQEGNT FKLQESIDPA GEETMSPTSP TLMPRMRSHS FYSVNMKDKG 1330 1340 1350 1360 1370 1380 GIEKLESIFK ERSLSLHRAT SSHSVAKEPK APAAPANTLA IVPDSRRPSS CIDIYVSAMD 1390 1400 1410 1420 1430 1440 ELHCDIDPLD NSVNILGLGE PSFSTPVPST APSSSAYATL APTDRPPSRS IDFEDITSMD 1450 1460 1470 1480 1490 1500 TRSFSSDYTH LPECQNPWDS EPPMYHTIER SKSSRYLATT PFLLEEAPIV KSHSFMFSPS 1510 1520 1530 1540 1550 1560 RSYYANFGVP VKTAEYTSIT DCIDTRCVNA PQAIADRAAF PGGLGDKVED LTCCHPEREA 1570 1580 1590 1600 1610 1620 ELSHPSSDSE ENEAKGRRAT IAISSQEGDN SERTLSNNIT VPKIERANSY SAEEPSAPYA 1630 1640 1650 1660 1670 HTRKSFSISD KLDRQRNTAS LRNPFQRSKS SKPEGRGDSL SMRRLSRTSA FQSFESKHN
	Isoform 10 [UniParc]. Checksum: 837BEDE795F5E400	FASTA	1,325	152,656
	10 20 30 40 50 60 MPEPWGTVYF LGIAQVFSFL FSWWNLEGVM NQADAPRPLN WTIRKLCHAA FLPSVRLLKA 70 80 90 100 110 120 QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT PSISVLQNEK NESRLSRNDI 130 140 150 160 170 180 QSEKWSISKH TQLSPTDAFG TIEFQGGGHS NKAMYVRVSF DTKPDLLLHL MTKEWQLELP 190 200 210 220 230 240 KLLISVHGGL QNFELQPKLK QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS 250 260 270 280 290 300 KSRGKICTIG IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT 310 320 330 340 350 360 GKYGAEVKLR RQLEKHISLQ KINTRIGQGV PVVALIVEGG PNVISIVLEY LRDTPPVPVV 370 380 390 400 410 420 VCDGSGRASD ILAFGHKYSE EGGLINESLR DQLLVTIQKT FTYTRTQAQH LFIILMECMK 430 440 450 460 470 480 KKELITVFRM GSEGHQDIDL AILTALLKGA NASAPDQLSL ALAWNRVDIA RSQIFIYGQQ 490 500 510 520 530 540 WPVGSLEQAM LDALVLDRVD FVKLLIENGV SMHRFLTISR LEELYNTRHG PSNTLYHLVR 550 560 570 580 590 600 DVKKGNLPPD YRISLIDIGL VIEYLMGGAY RCNYTRKRFR TLYHNLFGPK RPKALKLLGM 610 620 630 640 650 660 EDDIPLRRGR KTTKKREEEV DIDLDDPEIN HFPFPFHELM VWAVLMKRQK MALFFWQHGE 670 680 690 700 710 720 EAMAKALVAC KLCKAMAHEA SENDMVDDIS QELNHNSRDF GQLAVELLDQ SYKQDEQLAM 730 740 750 760 770 780 KLLTYELKNW SNATCLQLAV AAKHRDFIAH TCSQMLLTDM WMGRLRMRKN SGLKVILGIL 790 800 810 820 830 840 LPPSILSLEF KNKDDMPYMS QAQEIHLQEK EAEEPEKPTK EKEEEDMELT AMLGRNNGES 850 860 870 880 890 900 SRKKDEEEVQ SKHRLIPLGR KIYEFYNAPI VKFWFYTLAY IGYLMLFNYI VLVKMERWPS 910 920 930 940 950 960 TQEWIVISYI FTLGIEKMRE ILMSEPGKLL QKVKVWLQEY WNVTDLIAIL LFSVGMILRL 970 980 990 1000 1010 1020 QDQPFRSDGR VIYCVNIIYW YIRLLDIFGV NKYLGPYVMM IGKMMIDMMY FVIIMLVVLM 1030 1040 1050 1060 1070 1080 SFGVARQAIL FPNEEPSWKL AKNIFYMPYW MIYGEVFADQ IDPPCGQNET REDGKIIQLP 1090 1100 1110 1120 1130 1140 PCKTGAWIVP AIMACYLLVA NILLVNLLIA VFNNTFFEVK SISNQVWKFQ RYQLIMTFHE 1150 1160 1170 1180 1190 1200 RPVLPPPLII FSHMTMIFQH LCCRWRKHES DPDERDYGLK LFITDDELKK VHDFEEQCIE 1210 1220 1230 1240 1250 1260 EYFREKDDRF NSSNDERIRV TSERVENMSM RLEEVNEREH SMKASLQTVD IRLAQLEDLI 1270 1280 1290 1300 1310 1320 GRMATALERL TGLERAESNK IRSRTSSDCT DAAYIVRQSS FNSQEGNTFK LQESIDPAEH PLYSV
	Isoform 11 [UniParc]. Checksum: D536EBCD7F526C10	FASTA	1,734	197,679
	10 20 30 40 50 60 MGKKWRDAAE MERGCSDRED NAESRRRSRS ASRGRFAESW KRLSSKQGST KRSGLPSQQT 70 80 90 100 110 120 PAQKSWIERA FYKRECVHII PSTKDPHRCC CGRLIGQHVG LTPSISVLQN EKNESRLSRN 130 140 150 160 170 180 DIQSEKWSIS KHTQLSPTDA FGTIEFQGGG HSNKAMYVRV SFDTKPDLLL HLMTKEWQLE 190 200 210 220 230 240 LPKLLISVHG GLQNFELQPK LKQVFGKGLI KAAMTTGAWI FTGGVNTGVI RHVGDALKDH 250 260 270 280 290 300 ASKSRGKICT IGIAPWGIVE NQEDLIGRDV VRPYQTMSNP MSKLTVLNSM HSHFILADNG 310 320 330 340 350 360 TTGKYGAEVK LRRQLEKHIS LQKINTRCLP FFSLDSRLFY SFWGSCQLDS VGIGQGVPVV 370 380 390 400 410 420 ALIVEGGPNV ISIVLEYLRD TPPVPVVVCD GSGRASDILA FGHKYSEEGG LINESLRDQL 430 440 450 460 470 480 LVTIQKTFTY TRTQAQHLFI ILMECMKKKE LITVFRMGSE GHQDIDLAIL TALLKGANAS 490 500 510 520 530 540 APDQLSLALA WNRVDIARSQ IFIYGQQWPV GSLEQAMLDA LVLDRVDFVK LLIENGVSMH 550 560 570 580 590 600 RFLTISRLEE LYNTRHGPSN TLYHLVRDVK KGNLPPDYRI SLIDIGLVIE YLMGGAYRCN 610 620 630 640 650 660 YTRKRFRTLY HNLFGPKRPK ALKLLGMEDD IPLRRGRKTT KKREEEVDID LDDPEINHFP 670 680 690 700 710 720 FPFHELMVWA VLMKRQKMAL FFWQHGEEAM AKALVACKLC KAMAHEASEN DMVDDISQEL 730 740 750 760 770 780 NHNSRDFGQL AVELLDQSYK QDEQLAMKLL TYELKNWSNA TCLQLAVAAK HRDFIAHTCS 790 800 810 820 830 840 QMLLTDMWMG RLRMRKNSGL KVILGILLPP SILSLEFKNK DDMPYMSQAQ EIHLQEKEAE 850 860 870 880 890 900 EPEKPTKEKE EEDMELTAML GRNNGESSRK KDEEEVQSKH RLIPLGRKIY EFYNAPIVKF 910 920 930 940 950 960 WFYTLAYIGY LMLFNYIVLV KMERWPSTQE WIVISYIFTL GIEKMREILM SEPGKLLQKV 970 980 990 1000 1010 1020 KVWLQEYWNV TDLIAILLFS VGMILRLQDQ PFRSDGRVIY CVNIIYWYIR LLDIFGVNKY 1030 1040 1050 1060 1070 1080 LGPYVMMIGK MMIDMMYFVI IMLVVLMSFG VARQAILFPN EEPSWKLAKN IFYMPYWMIY 1090 1100 1110 1120 1130 1140 GEVFADQIDP PCGQNETRED GKIIQLPPCK TGAWIVPAIM ACYLLVANIL LVNLLIAVFN 1150 1160 1170 1180 1190 1200 NTFFEVKSIS NQVWKFQRYQ LIMTFHERPV LPPPLIIFSH MTMIFQHLCC RWRKHESDPD 1210 1220 1230 1240 1250 1260 ERDYGLKLFI TDDELKKVHD FEEQCIEEYF REKDDRFNSS NDERIRVTSE RVENMSMRLE 1270 1280 1290 1300 1310 1320 EVNEREHSMK ASLQTVDIRL AQLEDLIGRM ATALERLTGL ERAESNKIRS RTSSDCTDAA 1330 1340 1350 1360 1370 1380 YIVRQSSFNS QEGNTFKLQE SIDPAGEETM SPTSPTLMPR MRSHSFYSVN MKDKGGIEKL 1390 1400 1410 1420 1430 1440 ESIFKERSLS LHRATSSHSV AKEPKAPAAP ANTLAIVPDS RRPSSCIDIY VSAMDELHCD 1450 1460 1470 1480 1490 1500 IDPLDNSVNI LGLGEPSFST PVPSTAPSSS AYATLAPTDR PPSRSIDFED ITSMDTRSFS 1510 1520 1530 1540 1550 1560 SDYTHLPECQ NPWDSEPPMY HTIERSKSSR YLATTPFLLE EAPIVKSHSF MFSPSRSYYA 1570 1580 1590 1600 1610 1620 NFGVPVKTAE YTSITDCIDT RCVNAPQAIA DRAAFPGGLG DKVEDLTCCH PEREAELSHP 1630 1640 1650 1660 1670 1680 SSDSEENEAK GRRATIAISS QEGDNSERTL SNNITVPKIE RANSYSAEEP SAPYAHTRKS 1690 1700 1710 1720 1730 FSISDKLDRQ RNTASLRNPF QRSKSSKPEG RGDSLSMRRL SRTSAFQSFE SKHN
	Isoform 12 [UniParc]. Checksum: 237AF35F9D6036F2	FASTA	230	25,159
	10 20 30 40 50 60 MYVRVSFDTK PDLLLHLMTK EWQLELPKLL ISVHGGLQNF ELQPKLKQVF GKGLIKAAMT 70 80 90 100 110 120 TGAWIFTGGV NTGVIRHVGD ALKDHASKSR GKICTIGIAP WGIVENQEDL IGRDVVRPYQ 130 140 150 160 170 180 TMSNPMSKLT VLNSMHSHFI LADNGTTGKY GAEVKLRRQL EKHISLQKIN TRIGQGVPVV 190 200 210 220 230 ALIVEGGPNV ISIVLEYLRD TPPVPVVVCD GSGRASDILA FGHKYSEEGG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and functional characterization of the melastatin-related cation channel TRPM3." Grimm C., Kraft R., Sauerbruch S., Schultz G., Harteneck C. J. Biol. Chem. 278:21493-21501(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 10), FUNCTION, TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 12).
[4]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-324 (ISOFORM 11). Tissue: Amygdala.
[5]	"Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3)." Lee N., Chen J., Sun L., Wu S., Gray K.R., Rich A., Huang M., Lin J.-H., Feder J.N., Janovitz E.B., Levesque P.C., Blanar M.A. J. Biol. Chem. 278:20890-20897(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 154-1732 (ISOFORMS 1; 2; 3; 4; 5 AND 6), VARIANT THR-1732, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[6]	"ProX human full-length cDNA cloning project." Okabayashi K., Hirano K., Sano M., Murahashi Y., Miyauchi A., Gonoi T. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 154-1732 (ISOFORMS 1; 2; 4; 7 AND 8), VARIANT THR-1732. Tissue: Brain.
[7]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 716-1732 (ISOFORMS 1/2/3/4/5/7/8), VARIANTS LYS-1717 AND THR-1732. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ505025 mRNA. Translation: CAD43604.1. AJ505026 mRNA. Translation: CAD43605.1. AL159990, AL356318 Genomic DNA. Translation: CAI12193.1. AL356318, AL159990 Genomic DNA. Translation: CAI96096.1. AL159990 , AL161913, AL356318, AL358786, AL442645 Genomic DNA. Translation: CAM13096.1. Sequence problems. AL356318 , AL159990, AL161913, AL358786, AL442645 Genomic DNA. Translation: CAM13169.1. Sequence problems. AL358786 , AL159990, AL161913, AL356318, AL442645 Genomic DNA. Translation: CAM15782.1. Sequence problems. AL442645 , AL159990, AL161913, AL356318, AL358786 Genomic DNA. Translation: CAM17596.1. Sequence problems. AL161913 , AL159990, AL356318, AL358786, AL442645 Genomic DNA. Translation: CAM22746.1. Sequence problems. AL160273 Genomic DNA. No translation available. AL391819 Genomic DNA. No translation available. AL592438 Genomic DNA. No translation available. BC121821 mRNA. Translation: AAI21822.2. BC134414 mRNA. Translation: AAI34415.1. BC142972 mRNA. Translation: AAI42973.1. AL136545 mRNA. Translation: CAB66480.2. Sequence problems. AF536748 mRNA. Translation: AAO49153.1. AF536749 mRNA. Translation: AAO49154.1. AF536750 mRNA. Translation: AAO49155.1. AF536751 mRNA. Translation: AAO49156.1. AF536752 mRNA. Translation: AAO49157.1. AF536753 mRNA. Translation: AAO49158.1. AB099661 mRNA. Translation: BAC55102.1. AB099662 mRNA. Translation: BAC55103.1. AB099663 mRNA. Translation: BAC55104.1. AB099664 mRNA. Translation: BAC55105.1. AB099665 mRNA. Translation: BAC55106.1. AB046836 mRNA. Translation: BAB13442.1.
IPI	IPI00328399. IPI00410153. IPI00410304. IPI00410306. IPI00479292. IPI00552215. IPI00552239. IPI00552380. IPI00553010. IPI00654589. IPI00964809.
RefSeq	NP_001007472.2. NM_001007471.2. NP_996831.1. NM_206948.2.
UniGene	Hs.47288.
3D structure databases
ModBase	Search...
Protein family/group databases
TCDB	1.A.4.5.6. transient receptor potential Ca2+ channel (TRP-CC) family.
PTM databases
PhosphoSite	Q9HCF6.
Polymorphism databases
DMDM	212276493.
Proteomic databases
PaxDb	Q9HCF6.
PRIDE	Q9HCF6.
Protocols and materials databases
DNASU	80036.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361823; ENSP00000355395; ENSG00000083067. ENST00000377110; ENSP00000366314; ENSG00000083067. ENST00000377111; ENSP00000366315; ENSG00000083067. ENST00000423814; ENSP00000389542; ENSG00000083067.
GeneID	80036.
KEGG	hsa:80036.
UCSC	uc004ahv.3. human. uc004ahw.3. human. uc004ahx.3. human. uc004ahz.3. human. uc004aia.3. human. uc004aib.3. human. uc004aic.3. human.
Organism-specific databases
CTD	80036.
GeneCards	GC09M073149.
HGNC	HGNC:17992. TRPM3.
MIM	608961. gene.
neXtProt	NX_Q9HCF6.
PharmGKB	PA38271.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG253824.
HOGENOM	HOG000230920.
HOVERGEN	HBG058254.
InParanoid	Q9HCF6.
KO	K04978.
OMA	YIVRQSS.
Gene expression databases
ArrayExpress	Q9HCF6.
Bgee	Q9HCF6.
Genevestigator	Q9HCF6.
GermOnline	ENSG00000083067. Homo sapiens.
Family and domain databases
InterPro	IPR005821. Ion_trans_dom. [Graphical view]
Pfam	PF00520. Ion_trans. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TRPM3. human.
GenomeRNAi	80036.
NextBio	70216.
SOURCE	Search...

Entry information

Entry name

TRPM3_HUMAN

Accession

Primary (citable) accession number: Q9HCF6
Secondary accession number(s): A2A3F6 , A9Z1Y7, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01, Q9H0X2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	February 8, 2011
Last modified:	April 3, 2013
This is version 99 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.