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Q9HCF6

- TRPM3_HUMAN

UniProt

Q9HCF6 - TRPM3_HUMAN

Protein

Transient receptor potential cation channel subfamily M member 3

Gene

TRPM3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 4 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.2 Publications

    GO - Molecular functioni

    1. calcium channel activity Source: UniProtKB-KW
    2. cation channel activity Source: MGI

    GO - Biological processi

    1. calcium ion transmembrane transport Source: Reactome
    2. cation transport Source: MGI
    3. ion transmembrane transport Source: Reactome
    4. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_169333. TRP channels.

    Protein family/group databases

    TCDBi1.A.4.5.6. the transient receptor potential ca(2+) channel (trp-cc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transient receptor potential cation channel subfamily M member 3
    Alternative name(s):
    Long transient receptor potential channel 3
    Short name:
    LTrpC-3
    Short name:
    LTrpC3
    Melastatin-2
    Short name:
    MLSN2
    Gene namesi
    Name:TRPM3
    Synonyms:KIAA1616, LTRPC3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:17992. TRPM3.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38271.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17321732Transient receptor potential cation channel subfamily M member 3PRO_0000215328Add
    BLAST

    Proteomic databases

    PaxDbiQ9HCF6.
    PRIDEiQ9HCF6.

    PTM databases

    PhosphoSiteiQ9HCF6.

    Expressioni

    Tissue specificityi

    Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney.2 Publications

    Gene expression databases

    ArrayExpressiQ9HCF6.
    BgeeiQ9HCF6.
    GenevestigatoriQ9HCF6.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4713703.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 794770CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini816 – 89782ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini919 – 96446CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini986 – 99510ExtracellularSequence Analysis
    Topological domaini1017 – 102812CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1050 – 111667ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1138 – 1732595CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei795 – 81521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei898 – 91821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei965 – 98521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei996 – 101621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1029 – 104921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1117 – 113721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1241 – 130161Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253824.
    HOGENOMiHOG000230920.
    HOVERGENiHBG058254.
    InParanoidiQ9HCF6.
    KOiK04978.
    OMAiKFWFYTL.
    OrthoDBiEOG7NPFSC.
    PhylomeDBiQ9HCF6.
    TreeFamiTF314204.

    Family and domain databases

    InterProiIPR005821. Ion_trans_dom.
    IPR029583. TRPM3.
    [Graphical view]
    PANTHERiPTHR13800:SF7. PTHR13800:SF7. 1 hit.
    PfamiPF00520. Ion_trans. 1 hit.
    [Graphical view]

    Sequences (11)i

    Sequence statusi: Complete.

    This entry describes 11 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HCF6-1) [UniParc]FASTAAdd to Basket

    Also known as: TRPM3f

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPEPWGTVYF LGIAQVFSFL FSWWNLEGVM NQADAPRPLN WTIRKLCHAA     50
    FLPSVRLLKA QKSWIERAFY KRECVHIIPS TKDPHRCCCG RLIGQHVGLT 100
    PSISVLQNEK NESRLSRNDI QSEKWSISKH TQLSPTDAFG TIEFQGGGHS 150
    NKAMYVRVSF DTKPDLLLHL MTKEWQLELP KLLISVHGGL QNFELQPKLK 200
    QVFGKGLIKA AMTTGAWIFT GGVNTGVIRH VGDALKDHAS KSRGKICTIG 250
    IAPWGIVENQ EDLIGRDVVR PYQTMSNPMS KLTVLNSMHS HFILADNGTT 300
    GKYGAEVKLR RQLEKHISLQ KINTRCLPFF SLDSRLFYSF WGSCQLDSVG 350
    IGQGVPVVAL IVEGGPNVIS IVLEYLRDTP PVPVVVCDGS GRASDILAFG 400
    HKYSEEGGLI NESLRDQLLV TIQKTFTYTR TQAQHLFIIL MECMKKKELI 450
    TVFRMGSEGH QDIDLAILTA LLKGANASAP DQLSLALAWN RVDIARSQIF 500
    IYGQQWPVGS LEQAMLDALV LDRVDFVKLL IENGVSMHRF LTISRLEELY 550
    NTRHGPSNTL YHLVRDVKKG NLPPDYRISL IDIGLVIEYL MGGAYRCNYT 600
    RKRFRTLYHN LFGPKRPKAL KLLGMEDDIP LRRGRKTTKK REEEVDIDLD 650
    DPEINHFPFP FHELMVWAVL MKRQKMALFF WQHGEEAMAK ALVACKLCKA 700
    MAHEASENDM VDDISQELNH NSRDFGQLAV ELLDQSYKQD EQLAMKLLTY 750
    ELKNWSNATC LQLAVAAKHR DFIAHTCSQM LLTDMWMGRL RMRKNSGLKV 800
    ILGILLPPSI LSLEFKNKDD MPYMSQAQEI HLQEKEAEEP EKPTKEKEEE 850
    DMELTAMLGR NNGESSRKKD EEEVQSKHRL IPLGRKIYEF YNAPIVKFWF 900
    YTLAYIGYLM LFNYIVLVKM ERWPSTQEWI VISYIFTLGI EKMREILMSE 950
    PGKLLQKVKV WLQEYWNVTD LIAILLFSVG MILRLQDQPF RSDGRVIYCV 1000
    NIIYWYIRLL DIFGVNKYLG PYVMMIGKMM IDMMYFVIIM LVVLMSFGVA 1050
    RQAILFPNEE PSWKLAKNIF YMPYWMIYGE VFADQIDPPC GQNETREDGK 1100
    IIQLPPCKTG AWIVPAIMAC YLLVANILLV NLLIAVFNNT FFEVKSISNQ 1150
    VWKFQRYQLI MTFHERPVLP PPLIIFSHMT MIFQHLCCRW RKHESDPDER 1200
    DYGLKLFITD DELKKVHDFE EQCIEEYFRE KDDRFNSSND ERIRVTSERV 1250
    ENMSMRLEEV NEREHSMKAS LQTVDIRLAQ LEDLIGRMAT ALERLTGLER 1300
    AESNKIRSRT SSDCTDAAYI VRQSSFNSQE GNTFKLQESI DPAGEETMSP 1350
    TSPTLMPRMR SHSFYSVNMK DKGGIEKLES IFKERSLSLH RATSSHSVAK 1400
    EPKAPAAPAN TLAIVPDSRR PSSCIDIYVS AMDELHCDID PLDNSVNILG 1450
    LGEPSFSTPV PSTAPSSSAY ATLAPTDRPP SRSIDFEDIT SMDTRSFSSD 1500
    YTHLPECQNP WDSEPPMYHT IERSKSSRYL ATTPFLLEEA PIVKSHSFMF 1550
    SPSRSYYANF GVPVKTAEYT SITDCIDTRC VNAPQAIADR AAFPGGLGDK 1600
    VEDLTCCHPE REAELSHPSS DSEENEAKGR RATIAISSQE GDNSERTLSN 1650
    NITVPKIERA NSYSAEEPSA PYAHTRKSFS ISDKLDRQRN TASLRNPFQR 1700
    SKSSKPEGRG DSLSMRRLSR TSAFQSFESK HN 1732
    Length:1,732
    Mass (Da):197,571
    Last modified:February 8, 2011 - v4
    Checksum:i0D6BE312C56646A4
    GO
    Isoform 2 (identifier: Q9HCF6-2) [UniParc]FASTAAdd to Basket

    Also known as: TRPM3a

    The sequence of this isoform differs from the canonical sequence as follows:
         326-350: Missing.

    Show »
    Length:1,707
    Mass (Da):194,714
    Checksum:i16522E65FD2FAA3F
    GO
    Isoform 3 (identifier: Q9HCF6-3) [UniParc]FASTAAdd to Basket

    Also known as: TRPM3b

    The sequence of this isoform differs from the canonical sequence as follows:
         326-350: Missing.
         569-569: K → KREYPGFGWIYFK

    Show »
    Length:1,719
    Mass (Da):196,259
    Checksum:i27EAFF76AFB0A46B
    GO
    Isoform 4 (identifier: Q9HCF6-4) [UniParc]FASTAAdd to Basket

    Also known as: TRPM3d

    The sequence of this isoform differs from the canonical sequence as follows:
         326-350: Missing.
         617-626: Missing.

    Show »
    Length:1,697
    Mass (Da):193,632
    Checksum:i144786F6D67B4F0B
    GO
    Isoform 5 (identifier: Q9HCF6-5) [UniParc]FASTAAdd to Basket

    Also known as: TRPM3e

    The sequence of this isoform differs from the canonical sequence as follows:
         326-350: Missing.
         569-569: K → KREYPGFGWIYFK
         617-626: Missing.

    Show »
    Length:1,709
    Mass (Da):195,177
    Checksum:iDA6133571BA70002
    GO
    Isoform 6 (identifier: Q9HCF6-6) [UniParc]FASTAAdd to Basket

    Also known as: TRPM3c

    The sequence of this isoform differs from the canonical sequence as follows:
         326-350: Missing.
         1088-1088: P → RKQVYDSHTPKSA

    Show »
    Length:1,719
    Mass (Da):196,115
    Checksum:i46BEADD398188191
    GO
    Isoform 7 (identifier: Q9HCF6-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         617-626: Missing.

    Show »
    Length:1,722
    Mass (Da):196,490
    Checksum:iE30BDDE5FB3E061B
    GO
    Isoform 8 (identifier: Q9HCF6-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         326-350: Missing.
         535-552: Missing.
         617-626: Missing.

    Show »
    Length:1,679
    Mass (Da):191,441
    Checksum:iC90DF3FAF79D9637
    GO
    Isoform 10 (identifier: Q9HCF6-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         326-350: Missing.
         1344-1350: GEETMSP → EHPLYSV
         1351-1732: Missing.

    Show »
    Length:1,325
    Mass (Da):152,656
    Checksum:i837BEDE795F5E400
    GO
    Isoform 11 (identifier: Q9HCF6-11) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-59: MPEPWGTVYF...AFLPSVRLLK → MGKKWRDAAE...RSGLPSQQTP

    Show »
    Length:1,734
    Mass (Da):197,679
    Checksum:iD536EBCD7F526C10
    GO
    Isoform 12 (identifier: Q9HCF6-12) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-153: Missing.
         326-350: Missing.
         409-1732: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:230
    Mass (Da):25,159
    Checksum:i237AF35F9D6036F2
    GO

    Sequence cautioni

    The sequence CAB66480.2 differs from that shown. Reason: Cloning artifact in C-terminus.
    The sequence CAM13096.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAM13169.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAM15782.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAM17596.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAM22746.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti335 – 3351R → H in BAC55103. 1 PublicationCurated
    Sequence conflicti695 – 6951C → Y in BAC55106. 1 PublicationCurated
    Sequence conflicti1032 – 10321D → E in BAC55106. 1 PublicationCurated
    Sequence conflicti1730 – 17301K → Q in BAC55104. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1653 – 16531T → I.
    Corresponds to variant rs13440436 [ dbSNP | Ensembl ].
    VAR_057305
    Natural varianti1695 – 16951R → Q.
    Corresponds to variant rs6560142 [ dbSNP | Ensembl ].
    VAR_021257
    Natural varianti1717 – 17171R → K.1 Publication
    Corresponds to variant rs41287373 [ dbSNP | Ensembl ].
    VAR_061862
    Natural varianti1732 – 17321N → T.3 Publications
    Corresponds to variant rs17535963 [ dbSNP | Ensembl ].
    VAR_057306

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 153153Missing in isoform 12. 1 PublicationVSP_043515Add
    BLAST
    Alternative sequencei1 – 5959MPEPW…VRLLK → MGKKWRDAAEMERGCSDRED NAESRRRSRSASRGRFAESW KRLSSKQGSTKRSGLPSQQT P in isoform 11. 1 PublicationVSP_039107Add
    BLAST
    Alternative sequencei326 – 35025Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 8, isoform 10 and isoform 12. 4 PublicationsVSP_012826Add
    BLAST
    Alternative sequencei409 – 17321324Missing in isoform 12. 1 PublicationVSP_043516Add
    BLAST
    Alternative sequencei535 – 55218Missing in isoform 8. 1 PublicationVSP_012827Add
    BLAST
    Alternative sequencei569 – 5691K → KREYPGFGWIYFK in isoform 3 and isoform 5. 1 PublicationVSP_012828
    Alternative sequencei617 – 62610Missing in isoform 4, isoform 5, isoform 7 and isoform 8. 2 PublicationsVSP_012829
    Alternative sequencei1088 – 10881P → RKQVYDSHTPKSA in isoform 6. 1 PublicationVSP_012830
    Alternative sequencei1344 – 13507GEETMSP → EHPLYSV in isoform 10. 1 PublicationVSP_012831
    Alternative sequencei1351 – 1732382Missing in isoform 10. 1 PublicationVSP_012832Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ505025 mRNA. Translation: CAD43604.1.
    AJ505026 mRNA. Translation: CAD43605.1.
    AL159990, AL356318 Genomic DNA. Translation: CAI12193.1.
    AL356318, AL159990 Genomic DNA. Translation: CAI96096.1.
    AL159990
    , AL161913, AL356318, AL358786, AL442645 Genomic DNA. Translation: CAM13096.1. Sequence problems.
    AL356318
    , AL159990, AL161913, AL358786, AL442645 Genomic DNA. Translation: CAM13169.1. Sequence problems.
    AL358786
    , AL159990, AL161913, AL356318, AL442645 Genomic DNA. Translation: CAM15782.1. Sequence problems.
    AL442645
    , AL159990, AL161913, AL356318, AL358786 Genomic DNA. Translation: CAM17596.1. Sequence problems.
    AL161913
    , AL159990, AL356318, AL358786, AL442645 Genomic DNA. Translation: CAM22746.1. Sequence problems.
    AL160273 Genomic DNA. No translation available.
    AL391819 Genomic DNA. No translation available.
    AL592438 Genomic DNA. No translation available.
    BC121821 mRNA. Translation: AAI21822.2.
    BC134414 mRNA. Translation: AAI34415.1.
    BC142972 mRNA. Translation: AAI42973.1.
    AL136545 mRNA. Translation: CAB66480.2. Sequence problems.
    AF536748 mRNA. Translation: AAO49153.1.
    AF536749 mRNA. Translation: AAO49154.1.
    AF536750 mRNA. Translation: AAO49155.1.
    AF536751 mRNA. Translation: AAO49156.1.
    AF536752 mRNA. Translation: AAO49157.1.
    AF536753 mRNA. Translation: AAO49158.1.
    AB099661 mRNA. Translation: BAC55102.1.
    AB099662 mRNA. Translation: BAC55103.1.
    AB099663 mRNA. Translation: BAC55104.1.
    AB099664 mRNA. Translation: BAC55105.1.
    AB099665 mRNA. Translation: BAC55106.1.
    AB046836 mRNA. Translation: BAB13442.1.
    CCDSiCCDS43835.1. [Q9HCF6-2]
    CCDS6637.1. [Q9HCF6-12]
    RefSeqiNP_001007472.2. NM_001007471.2. [Q9HCF6-2]
    NP_996831.1. NM_206948.2. [Q9HCF6-12]
    XP_005252275.1. XM_005252218.2. [Q9HCF6-11]
    UniGeneiHs.47288.

    Genome annotation databases

    EnsembliENST00000361823; ENSP00000355395; ENSG00000083067. [Q9HCF6-12]
    ENST00000377110; ENSP00000366314; ENSG00000083067. [Q9HCF6-2]
    ENST00000377111; ENSP00000366315; ENSG00000083067. [Q9HCF6-10]
    GeneIDi80036.
    KEGGihsa:80036.
    UCSCiuc004ahv.3. human. [Q9HCF6-8]
    uc004ahw.3. human. [Q9HCF6-1]
    uc004ahz.3. human. [Q9HCF6-5]
    uc004aia.3. human. [Q9HCF6-2]
    uc004aib.3. human. [Q9HCF6-4]
    uc004aic.3. human. [Q9HCF6-10]
    uc004aig.3. human. [Q9HCF6-12]

    Polymorphism databases

    DMDMi322510140.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ505025 mRNA. Translation: CAD43604.1 .
    AJ505026 mRNA. Translation: CAD43605.1 .
    AL159990 , AL356318 Genomic DNA. Translation: CAI12193.1 .
    AL356318 , AL159990 Genomic DNA. Translation: CAI96096.1 .
    AL159990
    , AL161913 , AL356318 , AL358786 , AL442645 Genomic DNA. Translation: CAM13096.1 . Sequence problems.
    AL356318
    , AL159990 , AL161913 , AL358786 , AL442645 Genomic DNA. Translation: CAM13169.1 . Sequence problems.
    AL358786
    , AL159990 , AL161913 , AL356318 , AL442645 Genomic DNA. Translation: CAM15782.1 . Sequence problems.
    AL442645
    , AL159990 , AL161913 , AL356318 , AL358786 Genomic DNA. Translation: CAM17596.1 . Sequence problems.
    AL161913
    , AL159990 , AL356318 , AL358786 , AL442645 Genomic DNA. Translation: CAM22746.1 . Sequence problems.
    AL160273 Genomic DNA. No translation available.
    AL391819 Genomic DNA. No translation available.
    AL592438 Genomic DNA. No translation available.
    BC121821 mRNA. Translation: AAI21822.2 .
    BC134414 mRNA. Translation: AAI34415.1 .
    BC142972 mRNA. Translation: AAI42973.1 .
    AL136545 mRNA. Translation: CAB66480.2 . Sequence problems.
    AF536748 mRNA. Translation: AAO49153.1 .
    AF536749 mRNA. Translation: AAO49154.1 .
    AF536750 mRNA. Translation: AAO49155.1 .
    AF536751 mRNA. Translation: AAO49156.1 .
    AF536752 mRNA. Translation: AAO49157.1 .
    AF536753 mRNA. Translation: AAO49158.1 .
    AB099661 mRNA. Translation: BAC55102.1 .
    AB099662 mRNA. Translation: BAC55103.1 .
    AB099663 mRNA. Translation: BAC55104.1 .
    AB099664 mRNA. Translation: BAC55105.1 .
    AB099665 mRNA. Translation: BAC55106.1 .
    AB046836 mRNA. Translation: BAB13442.1 .
    CCDSi CCDS43835.1. [Q9HCF6-2 ]
    CCDS6637.1. [Q9HCF6-12 ]
    RefSeqi NP_001007472.2. NM_001007471.2. [Q9HCF6-2 ]
    NP_996831.1. NM_206948.2. [Q9HCF6-12 ]
    XP_005252275.1. XM_005252218.2. [Q9HCF6-11 ]
    UniGenei Hs.47288.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4713703.

    Chemistry

    GuidetoPHARMACOLOGYi 495.

    Protein family/group databases

    TCDBi 1.A.4.5.6. the transient receptor potential ca(2+) channel (trp-cc) family.

    PTM databases

    PhosphoSitei Q9HCF6.

    Polymorphism databases

    DMDMi 322510140.

    Proteomic databases

    PaxDbi Q9HCF6.
    PRIDEi Q9HCF6.

    Protocols and materials databases

    DNASUi 80036.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361823 ; ENSP00000355395 ; ENSG00000083067 . [Q9HCF6-12 ]
    ENST00000377110 ; ENSP00000366314 ; ENSG00000083067 . [Q9HCF6-2 ]
    ENST00000377111 ; ENSP00000366315 ; ENSG00000083067 . [Q9HCF6-10 ]
    GeneIDi 80036.
    KEGGi hsa:80036.
    UCSCi uc004ahv.3. human. [Q9HCF6-8 ]
    uc004ahw.3. human. [Q9HCF6-1 ]
    uc004ahz.3. human. [Q9HCF6-5 ]
    uc004aia.3. human. [Q9HCF6-2 ]
    uc004aib.3. human. [Q9HCF6-4 ]
    uc004aic.3. human. [Q9HCF6-10 ]
    uc004aig.3. human. [Q9HCF6-12 ]

    Organism-specific databases

    CTDi 80036.
    GeneCardsi GC09M073149.
    HGNCi HGNC:17992. TRPM3.
    MIMi 608961. gene.
    neXtProti NX_Q9HCF6.
    PharmGKBi PA38271.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253824.
    HOGENOMi HOG000230920.
    HOVERGENi HBG058254.
    InParanoidi Q9HCF6.
    KOi K04978.
    OMAi KFWFYTL.
    OrthoDBi EOG7NPFSC.
    PhylomeDBi Q9HCF6.
    TreeFami TF314204.

    Enzyme and pathway databases

    Reactomei REACT_169333. TRP channels.

    Miscellaneous databases

    ChiTaRSi TRPM3. human.
    GeneWikii TRPM3.
    GenomeRNAii 80036.
    NextBioi 70216.
    PROi Q9HCF6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HCF6.
    Bgeei Q9HCF6.
    Genevestigatori Q9HCF6.

    Family and domain databases

    InterProi IPR005821. Ion_trans_dom.
    IPR029583. TRPM3.
    [Graphical view ]
    PANTHERi PTHR13800:SF7. PTHR13800:SF7. 1 hit.
    Pfami PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and functional characterization of the melastatin-related cation channel TRPM3."
      Grimm C., Kraft R., Sauerbruch S., Schultz G., Harteneck C.
      J. Biol. Chem. 278:21493-21501(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 10), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 12).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-324 (ISOFORM 11).
      Tissue: Amygdala.
    5. "Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3)."
      Lee N., Chen J., Sun L., Wu S., Gray K.R., Rich A., Huang M., Lin J.-H., Feder J.N., Janovitz E.B., Levesque P.C., Blanar M.A.
      J. Biol. Chem. 278:20890-20897(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 154-1732 (ISOFORMS 1; 2; 3; 4; 5 AND 6), VARIANT THR-1732, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    6. "ProX human full-length cDNA cloning project."
      Okabayashi K., Hirano K., Sano M., Murahashi Y., Miyauchi A., Gonoi T.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 154-1732 (ISOFORMS 1; 2; 4; 7 AND 8), VARIANT THR-1732.
      Tissue: Brain.
    7. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 716-1732 (ISOFORMS 1/2/3/4/5/7/8), VARIANTS LYS-1717 AND THR-1732.
      Tissue: Brain.

    Entry informationi

    Entry nameiTRPM3_HUMAN
    AccessioniPrimary (citable) accession number: Q9HCF6
    Secondary accession number(s): A2A3F6
    , A9Z1Y7, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01, Q9H0X2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3