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Protein

Rho guanine nucleotide exchange factor 10-like protein

Gene

ARHGEF10L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 10-like protein
Alternative name(s):
GrinchGEF
Gene namesi
Name:ARHGEF10L
Synonyms:GRINCHGEF, KIAA1626
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25540. ARHGEF10L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55160.
PharmGKBiPA142672586.

Polymorphism and mutation databases

BioMutaiARHGEF10L.
DMDMi317373481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003423611 – 1279Rho guanine nucleotide exchange factor 10-like proteinAdd BLAST1279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineCombined sources1
Modified residuei131PhosphotyrosineBy similarity1
Modified residuei152PhosphotyrosineBy similarity1
Modified residuei281PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HCE6.
MaxQBiQ9HCE6.
PaxDbiQ9HCE6.
PeptideAtlasiQ9HCE6.
PRIDEiQ9HCE6.

PTM databases

iPTMnetiQ9HCE6.
PhosphoSitePlusiQ9HCE6.

Expressioni

Tissue specificityi

Detected in heart, liver, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000074964.
CleanExiHS_ARHGEF10L.
ExpressionAtlasiQ9HCE6. baseline and differential.
GenevisibleiQ9HCE6. HS.

Organism-specific databases

HPAiHPA026426.
HPA026440.
HPA028115.

Interactioni

Subunit structurei

Interacts with RHOA, RHOB and RHOC.1 Publication

Protein-protein interaction databases

IntActiQ9HCE6. 5 interactors.
MINTiMINT-1388833.
STRINGi9606.ENSP00000355060.

Structurei

3D structure databases

ProteinModelPortaliQ9HCE6.
SMRiQ9HCE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini316 – 503DHPROSITE-ProRule annotationAdd BLAST188

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3522. Eukaryota.
KOG3524. Eukaryota.
ENOG410ZJK1. LUCA.
HOVERGENiHBG050570.
InParanoidiQ9HCE6.
KOiK16727.
OrthoDBiEOG091G0A3T.
PhylomeDBiQ9HCE6.
TreeFamiTF331430.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.30. 3 hits.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSNPPPQP AIGDQLVPGV PGPSSEAEDD PGEAFEFDDS DDEEDTSAAL
60 70 80 90 100
GVPSLAPERD TDPPLIHLDS IPVTDPDPAA APPGTGVPAW VSNGDAADAA
110 120 130 140 150
FSGARHSSWK RKSSRRIDRF TFPALEEDVI YDDVPCESPD AHQPGAERNL
160 170 180 190 200
LYEDAHRAGA PRQAEDLGWS SSEFESYSED SGEEAKPEVE VEPAKHRVSF
210 220 230 240 250
QPKLSPDLTR LKERYARTKR DILALRVGGR DMQELKHKYD CKMTQLMKAA
260 270 280 290 300
KSGTKDGLEK TRMAVMRKVS FLHRKDVLGD SEEEDMGLLE VSVSDIKPPA
310 320 330 340 350
PELGPMPEGL SPQQVVRRHI LGSIVQSEGS YVESLKRILQ DYRNPLMEME
360 370 380 390 400
PKALSARKCQ VVFFRVKEIL HCHSMFQIAL SSRVAEWDST EKIGDLFVAS
410 420 430 440 450
FSKSMVLDVY SDYVNNFTSA MSIIKKACLT KPAFLEFLKR RQVCSPDRVT
460 470 480 490 500
LYGLMVKPIQ RFPQFILLLQ DMLKNTPRGH PDRLSLQLAL TELETLAEKL
510 520 530 540 550
NEQKRLADQV AEIQQLTKSV SDRSSLNKLL TSGQRQLLLC ETLTETVYGD
560 570 580 590 600
RGQLIKSKER RVFLLNDMLV CANINFKPAN HRGQLEISSL VPLGPKYVVK
610 620 630 640 650
WNTALPQVQV VEVGQDGGTY DKDNVLIQHS GAKKASASGQ AQNKVYLGPP
660 670 680 690 700
RLFQELQDLQ KDLAVVEQIT LLISTLHGTY QNLNMTVAQD WCLALQRLMR
710 720 730 740 750
VKEEEIHSAN KCRLRLLLPG KPDKSGRPIS FMVVFITPNP LSKISWVNRL
760 770 780 790 800
HLAKIGLREE NQPGWLCPDE DKKSKAPFWC PILACCIPAF SSRALSLQLG
810 820 830 840 850
ALVHSPVNCP LLGFSAVSTS LPQGYLWVGG GQEGAGGQVE IFSLNRPSPR
860 870 880 890 900
TVKSFPLAAP VLCMEYIPEL EEEAESRDES PTVADPSATV HPTICLGLQD
910 920 930 940 950
GSILLYSSVD TGTQCLVSCR SPGLQPVLCL RHSPFHLLAG LQDGTLAAYP
960 970 980 990 1000
RTSGGVLWDL ESPPVCLTVG PGPVRTLLSL EDAVWASCGP WVTVLEATTL
1010 1020 1030 1040 1050
QPQQSFEAHQ DEAVSVTHMV KAGSGVWMAF SSGTSIRLFH TETLEHLQEI
1060 1070 1080 1090 1100
NIATRTTFLL PGQKHLCVTS LLICQGLLWV GTDQGVIVLL PVPRLEGIPK
1110 1120 1130 1140 1150
ITGKGMVSLN GHCGPVAFLA VATSILAPDI LRSDQEEAEG PRAEEDKPDG
1160 1170 1180 1190 1200
QAHEPMPDSH VGRELTRKKG ILLQYRLRST AHLPGPLLSM REPAPADGAA
1210 1220 1230 1240 1250
LEHSEEDGSI YEMADDPDIW VRSRPCARDA HRKEICSVAI ISGGQGYRNF
1260 1270
GSALGSSGRQ APCGETDSTL LIWQVPLML
Length:1,279
Mass (Da):140,409
Last modified:January 11, 2011 - v3
Checksum:i1F0AC65D7B956DE6
GO
Isoform 2 (identifier: Q9HCE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-241: Missing.

Show »
Length:1,240
Mass (Da):135,753
Checksum:i444F7F8E64172E2D
GO
Isoform 3 (identifier: Q9HCE6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-241: Missing.
     578-582: Missing.

Show »
Length:1,235
Mass (Da):135,177
Checksum:i847C6A6291EB7CAF
GO
Isoform 4 (identifier: Q9HCE6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-221: Missing.
     222-278: ILALRVGGRD...VSFLHRKDVL → MLPSSSWGKR...SSSSSSVSCS
     401-470: Missing.
     578-582: Missing.

Show »
Length:982
Mass (Da):107,466
Checksum:iC972B270433F542A
GO
Isoform 5 (identifier: Q9HCE6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     578-582: Missing.
     1062-1072: GQKHLCVTSLL → DRSLIKCSPRA
     1073-1279: Missing.

Note: No experimental confirmation available.
Show »
Length:1,067
Mass (Da):117,651
Checksum:i290B5863B5B4BD72
GO

Sequence cautioni

The sequence BAA91663 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB13452 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC03792 differs from that shown. Reason: Erroneous termination at position 931. Translated as Arg.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24S → P in AAZ73162 (PubMed:16112081).Curated1
Sequence conflicti924L → P in BAA91663 (PubMed:14702039).Curated1
Sequence conflicti1006F → S in BAA91663 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06179447S → N.Corresponds to variant rs34417109dbSNPEnsembl.1
Natural variantiVAR_04418369D → N.Corresponds to variant rs35497285dbSNPEnsembl.1
Natural variantiVAR_04418496A → V in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_044185991W → R.4 PublicationsCorresponds to variant rs6695710dbSNPEnsembl.1
Natural variantiVAR_0441861219I → V.3 PublicationsCorresponds to variant rs2270976dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0344201 – 221Missing in isoform 4. 1 PublicationAdd BLAST221
Alternative sequenceiVSP_034421203 – 241Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_034422222 – 278ILALR…RKDVL → MLPSSSWGKRKLRGRLGWVR SDARGVMWARQEGLHHPHPH AVIRCPSSSSSSVSCS in isoform 4. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_034423401 – 470Missing in isoform 4. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_034424578 – 582Missing in isoform 3, isoform 4 and isoform 5. 3 Publications5
Alternative sequenceiVSP_0344251062 – 1072GQKHLCVTSLL → DRSLIKCSPRA in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0344261073 – 1279Missing in isoform 5. 1 PublicationAdd BLAST207

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ139833 mRNA. Translation: AAZ73162.1.
AB046846 mRNA. Translation: BAB13452.1. Different initiation.
AK001383 mRNA. Translation: BAA91663.1. Different initiation.
AK092020 mRNA. Translation: BAC03792.1. Sequence problems.
AL358593, AL139250 Genomic DNA. Translation: CAH74135.1.
AL358593, AL139250 Genomic DNA. Translation: CAH74136.1.
AL139250, AL358593 Genomic DNA. Translation: CAI22139.1.
AL139250, AL358593 Genomic DNA. Translation: CAI22140.1.
BC065561 mRNA. Translation: AAH65561.1.
BC080596 mRNA. Translation: AAH80596.1.
BC117171 mRNA. Translation: AAI17172.1.
BC143347 mRNA. Translation: AAI43348.1.
CCDSiCCDS182.1. [Q9HCE6-1]
CCDS30617.1. [Q9HCE6-2]
RefSeqiNP_001011722.2. NM_001011722.2.
NP_001306766.1. NM_001319837.1.
NP_001306767.1. NM_001319838.1.
NP_001315053.1. NM_001328124.1.
NP_060595.3. NM_018125.3.
UniGeneiHs.443460.

Genome annotation databases

EnsembliENST00000167825; ENSP00000167825; ENSG00000074964.
ENST00000361221; ENSP00000355060; ENSG00000074964.
ENST00000375415; ENSP00000364564; ENSG00000074964.
GeneIDi55160.
KEGGihsa:55160.
UCSCiuc001ban.4. human. [Q9HCE6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ139833 mRNA. Translation: AAZ73162.1.
AB046846 mRNA. Translation: BAB13452.1. Different initiation.
AK001383 mRNA. Translation: BAA91663.1. Different initiation.
AK092020 mRNA. Translation: BAC03792.1. Sequence problems.
AL358593, AL139250 Genomic DNA. Translation: CAH74135.1.
AL358593, AL139250 Genomic DNA. Translation: CAH74136.1.
AL139250, AL358593 Genomic DNA. Translation: CAI22139.1.
AL139250, AL358593 Genomic DNA. Translation: CAI22140.1.
BC065561 mRNA. Translation: AAH65561.1.
BC080596 mRNA. Translation: AAH80596.1.
BC117171 mRNA. Translation: AAI17172.1.
BC143347 mRNA. Translation: AAI43348.1.
CCDSiCCDS182.1. [Q9HCE6-1]
CCDS30617.1. [Q9HCE6-2]
RefSeqiNP_001011722.2. NM_001011722.2.
NP_001306766.1. NM_001319837.1.
NP_001306767.1. NM_001319838.1.
NP_001315053.1. NM_001328124.1.
NP_060595.3. NM_018125.3.
UniGeneiHs.443460.

3D structure databases

ProteinModelPortaliQ9HCE6.
SMRiQ9HCE6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9HCE6. 5 interactors.
MINTiMINT-1388833.
STRINGi9606.ENSP00000355060.

PTM databases

iPTMnetiQ9HCE6.
PhosphoSitePlusiQ9HCE6.

Polymorphism and mutation databases

BioMutaiARHGEF10L.
DMDMi317373481.

Proteomic databases

EPDiQ9HCE6.
MaxQBiQ9HCE6.
PaxDbiQ9HCE6.
PeptideAtlasiQ9HCE6.
PRIDEiQ9HCE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000167825; ENSP00000167825; ENSG00000074964.
ENST00000361221; ENSP00000355060; ENSG00000074964.
ENST00000375415; ENSP00000364564; ENSG00000074964.
GeneIDi55160.
KEGGihsa:55160.
UCSCiuc001ban.4. human. [Q9HCE6-1]

Organism-specific databases

CTDi55160.
DisGeNETi55160.
GeneCardsiARHGEF10L.
HGNCiHGNC:25540. ARHGEF10L.
HPAiHPA026426.
HPA026440.
HPA028115.
MIMi612494. gene.
neXtProtiNX_Q9HCE6.
PharmGKBiPA142672586.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3522. Eukaryota.
KOG3524. Eukaryota.
ENOG410ZJK1. LUCA.
HOVERGENiHBG050570.
InParanoidiQ9HCE6.
KOiK16727.
OrthoDBiEOG091G0A3T.
PhylomeDBiQ9HCE6.
TreeFamiTF331430.

Enzyme and pathway databases

ReactomeiR-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.

Miscellaneous databases

ChiTaRSiARHGEF10L. human.
GenomeRNAii55160.
PROiQ9HCE6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000074964.
CleanExiHS_ARHGEF10L.
ExpressionAtlasiQ9HCE6. baseline and differential.
GenevisibleiQ9HCE6. HS.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.30. 3 hits.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGAL_HUMAN
AccessioniPrimary (citable) accession number: Q9HCE6
Secondary accession number(s): B7ZKS1
, Q17RW1, Q3YFJ4, Q5VXI5, Q5VXI6, Q66K51, Q6P0L7, Q8NAV5, Q9NVT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.