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Protein

Rho guanine nucleotide exchange factor 10-like protein

Gene

ARHGEF10L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 10-like protein
Alternative name(s):
GrinchGEF
Gene namesi
Name:ARHGEF10L
Synonyms:GRINCHGEF, KIAA1626
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25540. ARHGEF10L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672586.

Polymorphism and mutation databases

BioMutaiARHGEF10L.
DMDMi317373481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12791279Rho guanine nucleotide exchange factor 10-like proteinPRO_0000342361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401PhosphoserineCombined sources
Modified residuei131 – 1311PhosphotyrosineBy similarity
Modified residuei152 – 1521PhosphotyrosineBy similarity
Modified residuei281 – 2811PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HCE6.
MaxQBiQ9HCE6.
PaxDbiQ9HCE6.
PeptideAtlasiQ9HCE6.
PRIDEiQ9HCE6.

PTM databases

iPTMnetiQ9HCE6.
PhosphoSiteiQ9HCE6.

Expressioni

Tissue specificityi

Detected in heart, liver, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000074964.
CleanExiHS_ARHGEF10L.
ExpressionAtlasiQ9HCE6. baseline and differential.
GenevisibleiQ9HCE6. HS.

Organism-specific databases

HPAiHPA026426.
HPA026440.
HPA028115.

Interactioni

Subunit structurei

Interacts with RHOA, RHOB and RHOC.1 Publication

Protein-protein interaction databases

IntActiQ9HCE6. 5 interactions.
MINTiMINT-1388833.
STRINGi9606.ENSP00000355060.

Structurei

3D structure databases

ProteinModelPortaliQ9HCE6.
SMRiQ9HCE6. Positions 310-600, 836-868, 893-951, 973-1010, 1016-1052.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini316 – 503188DHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3522. Eukaryota.
KOG3524. Eukaryota.
ENOG410ZJK1. LUCA.
HOVERGENiHBG050570.
InParanoidiQ9HCE6.
KOiK16727.
OrthoDBiEOG091G0A3T.
PhylomeDBiQ9HCE6.
TreeFamiTF331430.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSNPPPQP AIGDQLVPGV PGPSSEAEDD PGEAFEFDDS DDEEDTSAAL
60 70 80 90 100
GVPSLAPERD TDPPLIHLDS IPVTDPDPAA APPGTGVPAW VSNGDAADAA
110 120 130 140 150
FSGARHSSWK RKSSRRIDRF TFPALEEDVI YDDVPCESPD AHQPGAERNL
160 170 180 190 200
LYEDAHRAGA PRQAEDLGWS SSEFESYSED SGEEAKPEVE VEPAKHRVSF
210 220 230 240 250
QPKLSPDLTR LKERYARTKR DILALRVGGR DMQELKHKYD CKMTQLMKAA
260 270 280 290 300
KSGTKDGLEK TRMAVMRKVS FLHRKDVLGD SEEEDMGLLE VSVSDIKPPA
310 320 330 340 350
PELGPMPEGL SPQQVVRRHI LGSIVQSEGS YVESLKRILQ DYRNPLMEME
360 370 380 390 400
PKALSARKCQ VVFFRVKEIL HCHSMFQIAL SSRVAEWDST EKIGDLFVAS
410 420 430 440 450
FSKSMVLDVY SDYVNNFTSA MSIIKKACLT KPAFLEFLKR RQVCSPDRVT
460 470 480 490 500
LYGLMVKPIQ RFPQFILLLQ DMLKNTPRGH PDRLSLQLAL TELETLAEKL
510 520 530 540 550
NEQKRLADQV AEIQQLTKSV SDRSSLNKLL TSGQRQLLLC ETLTETVYGD
560 570 580 590 600
RGQLIKSKER RVFLLNDMLV CANINFKPAN HRGQLEISSL VPLGPKYVVK
610 620 630 640 650
WNTALPQVQV VEVGQDGGTY DKDNVLIQHS GAKKASASGQ AQNKVYLGPP
660 670 680 690 700
RLFQELQDLQ KDLAVVEQIT LLISTLHGTY QNLNMTVAQD WCLALQRLMR
710 720 730 740 750
VKEEEIHSAN KCRLRLLLPG KPDKSGRPIS FMVVFITPNP LSKISWVNRL
760 770 780 790 800
HLAKIGLREE NQPGWLCPDE DKKSKAPFWC PILACCIPAF SSRALSLQLG
810 820 830 840 850
ALVHSPVNCP LLGFSAVSTS LPQGYLWVGG GQEGAGGQVE IFSLNRPSPR
860 870 880 890 900
TVKSFPLAAP VLCMEYIPEL EEEAESRDES PTVADPSATV HPTICLGLQD
910 920 930 940 950
GSILLYSSVD TGTQCLVSCR SPGLQPVLCL RHSPFHLLAG LQDGTLAAYP
960 970 980 990 1000
RTSGGVLWDL ESPPVCLTVG PGPVRTLLSL EDAVWASCGP WVTVLEATTL
1010 1020 1030 1040 1050
QPQQSFEAHQ DEAVSVTHMV KAGSGVWMAF SSGTSIRLFH TETLEHLQEI
1060 1070 1080 1090 1100
NIATRTTFLL PGQKHLCVTS LLICQGLLWV GTDQGVIVLL PVPRLEGIPK
1110 1120 1130 1140 1150
ITGKGMVSLN GHCGPVAFLA VATSILAPDI LRSDQEEAEG PRAEEDKPDG
1160 1170 1180 1190 1200
QAHEPMPDSH VGRELTRKKG ILLQYRLRST AHLPGPLLSM REPAPADGAA
1210 1220 1230 1240 1250
LEHSEEDGSI YEMADDPDIW VRSRPCARDA HRKEICSVAI ISGGQGYRNF
1260 1270
GSALGSSGRQ APCGETDSTL LIWQVPLML
Length:1,279
Mass (Da):140,409
Last modified:January 11, 2011 - v3
Checksum:i1F0AC65D7B956DE6
GO
Isoform 2 (identifier: Q9HCE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-241: Missing.

Show »
Length:1,240
Mass (Da):135,753
Checksum:i444F7F8E64172E2D
GO
Isoform 3 (identifier: Q9HCE6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-241: Missing.
     578-582: Missing.

Show »
Length:1,235
Mass (Da):135,177
Checksum:i847C6A6291EB7CAF
GO
Isoform 4 (identifier: Q9HCE6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-221: Missing.
     222-278: ILALRVGGRD...VSFLHRKDVL → MLPSSSWGKR...SSSSSSVSCS
     401-470: Missing.
     578-582: Missing.

Show »
Length:982
Mass (Da):107,466
Checksum:iC972B270433F542A
GO
Isoform 5 (identifier: Q9HCE6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     578-582: Missing.
     1062-1072: GQKHLCVTSLL → DRSLIKCSPRA
     1073-1279: Missing.

Note: No experimental confirmation available.
Show »
Length:1,067
Mass (Da):117,651
Checksum:i290B5863B5B4BD72
GO

Sequence cautioni

The sequence BAA91663 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB13452 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC03792 differs from that shown. Reason: Erroneous termination at position 931. Translated as Arg.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241S → P in AAZ73162 (PubMed:16112081).Curated
Sequence conflicti924 – 9241L → P in BAA91663 (PubMed:14702039).Curated
Sequence conflicti1006 – 10061F → S in BAA91663 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471S → N.
Corresponds to variant rs34417109 [ dbSNP | Ensembl ].
VAR_061794
Natural varianti69 – 691D → N.
Corresponds to variant rs35497285 [ dbSNP | Ensembl ].
VAR_044183
Natural varianti96 – 961A → V in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_044184
Natural varianti991 – 9911W → R.4 Publications
Corresponds to variant rs6695710 [ dbSNP | Ensembl ].
VAR_044185
Natural varianti1219 – 12191I → V.3 Publications
Corresponds to variant rs2270976 [ dbSNP | Ensembl ].
VAR_044186

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 221221Missing in isoform 4. 1 PublicationVSP_034420Add
BLAST
Alternative sequencei203 – 24139Missing in isoform 2 and isoform 3. 2 PublicationsVSP_034421Add
BLAST
Alternative sequencei222 – 27857ILALR…RKDVL → MLPSSSWGKRKLRGRLGWVR SDARGVMWARQEGLHHPHPH AVIRCPSSSSSSVSCS in isoform 4. 1 PublicationVSP_034422Add
BLAST
Alternative sequencei401 – 47070Missing in isoform 4. 1 PublicationVSP_034423Add
BLAST
Alternative sequencei578 – 5825Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsVSP_034424
Alternative sequencei1062 – 107211GQKHLCVTSLL → DRSLIKCSPRA in isoform 5. 1 PublicationVSP_034425Add
BLAST
Alternative sequencei1073 – 1279207Missing in isoform 5. 1 PublicationVSP_034426Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ139833 mRNA. Translation: AAZ73162.1.
AB046846 mRNA. Translation: BAB13452.1. Different initiation.
AK001383 mRNA. Translation: BAA91663.1. Different initiation.
AK092020 mRNA. Translation: BAC03792.1. Sequence problems.
AL358593, AL139250 Genomic DNA. Translation: CAH74135.1.
AL358593, AL139250 Genomic DNA. Translation: CAH74136.1.
AL139250, AL358593 Genomic DNA. Translation: CAI22139.1.
AL139250, AL358593 Genomic DNA. Translation: CAI22140.1.
BC065561 mRNA. Translation: AAH65561.1.
BC080596 mRNA. Translation: AAH80596.1.
BC117171 mRNA. Translation: AAI17172.1.
BC143347 mRNA. Translation: AAI43348.1.
CCDSiCCDS182.1. [Q9HCE6-1]
CCDS30617.1. [Q9HCE6-2]
RefSeqiNP_001011722.2. NM_001011722.2.
NP_001306766.1. NM_001319837.1.
NP_001306767.1. NM_001319838.1.
NP_060595.3. NM_018125.3.
UniGeneiHs.443460.

Genome annotation databases

EnsembliENST00000167825; ENSP00000167825; ENSG00000074964.
ENST00000361221; ENSP00000355060; ENSG00000074964.
ENST00000375415; ENSP00000364564; ENSG00000074964.
GeneIDi55160.
KEGGihsa:55160.
UCSCiuc001ban.4. human. [Q9HCE6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ139833 mRNA. Translation: AAZ73162.1.
AB046846 mRNA. Translation: BAB13452.1. Different initiation.
AK001383 mRNA. Translation: BAA91663.1. Different initiation.
AK092020 mRNA. Translation: BAC03792.1. Sequence problems.
AL358593, AL139250 Genomic DNA. Translation: CAH74135.1.
AL358593, AL139250 Genomic DNA. Translation: CAH74136.1.
AL139250, AL358593 Genomic DNA. Translation: CAI22139.1.
AL139250, AL358593 Genomic DNA. Translation: CAI22140.1.
BC065561 mRNA. Translation: AAH65561.1.
BC080596 mRNA. Translation: AAH80596.1.
BC117171 mRNA. Translation: AAI17172.1.
BC143347 mRNA. Translation: AAI43348.1.
CCDSiCCDS182.1. [Q9HCE6-1]
CCDS30617.1. [Q9HCE6-2]
RefSeqiNP_001011722.2. NM_001011722.2.
NP_001306766.1. NM_001319837.1.
NP_001306767.1. NM_001319838.1.
NP_060595.3. NM_018125.3.
UniGeneiHs.443460.

3D structure databases

ProteinModelPortaliQ9HCE6.
SMRiQ9HCE6. Positions 310-600, 836-868, 893-951, 973-1010, 1016-1052.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9HCE6. 5 interactions.
MINTiMINT-1388833.
STRINGi9606.ENSP00000355060.

PTM databases

iPTMnetiQ9HCE6.
PhosphoSiteiQ9HCE6.

Polymorphism and mutation databases

BioMutaiARHGEF10L.
DMDMi317373481.

Proteomic databases

EPDiQ9HCE6.
MaxQBiQ9HCE6.
PaxDbiQ9HCE6.
PeptideAtlasiQ9HCE6.
PRIDEiQ9HCE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000167825; ENSP00000167825; ENSG00000074964.
ENST00000361221; ENSP00000355060; ENSG00000074964.
ENST00000375415; ENSP00000364564; ENSG00000074964.
GeneIDi55160.
KEGGihsa:55160.
UCSCiuc001ban.4. human. [Q9HCE6-1]

Organism-specific databases

CTDi55160.
GeneCardsiARHGEF10L.
HGNCiHGNC:25540. ARHGEF10L.
HPAiHPA026426.
HPA026440.
HPA028115.
MIMi612494. gene.
neXtProtiNX_Q9HCE6.
PharmGKBiPA142672586.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3522. Eukaryota.
KOG3524. Eukaryota.
ENOG410ZJK1. LUCA.
HOVERGENiHBG050570.
InParanoidiQ9HCE6.
KOiK16727.
OrthoDBiEOG091G0A3T.
PhylomeDBiQ9HCE6.
TreeFamiTF331430.

Miscellaneous databases

ChiTaRSiARHGEF10L. human.
GenomeRNAii55160.
PROiQ9HCE6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000074964.
CleanExiHS_ARHGEF10L.
ExpressionAtlasiQ9HCE6. baseline and differential.
GenevisibleiQ9HCE6. HS.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.130.10.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGAL_HUMAN
AccessioniPrimary (citable) accession number: Q9HCE6
Secondary accession number(s): B7ZKS1
, Q17RW1, Q3YFJ4, Q5VXI5, Q5VXI6, Q66K51, Q6P0L7, Q8NAV5, Q9NVT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: January 11, 2011
Last modified: September 7, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.