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Protein

Zinc finger protein 532

Gene

ZNF532

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri616 – 635C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri754 – 779C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri783 – 805C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri842 – 865C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri870 – 893C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri905 – 927C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri936 – 959C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1025 – 1048C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1055 – 1078C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1085 – 1111C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1203 – 1226C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1264 – 1286C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000074657-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 532
Gene namesi
Name:ZNF532
Synonyms:KIAA1629
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:30940. ZNF532.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55205.
OpenTargetsiENSG00000074657.
PharmGKBiPA134901858.

Polymorphism and mutation databases

BioMutaiZNF532.
DMDMi158564020.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002995521 – 1301Zinc finger protein 532Add BLAST1301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei175N6-acetyllysineBy similarity1
Modified residuei205PhosphothreonineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei1140PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9HCE3.
MaxQBiQ9HCE3.
PaxDbiQ9HCE3.
PeptideAtlasiQ9HCE3.
PRIDEiQ9HCE3.

PTM databases

iPTMnetiQ9HCE3.
PhosphoSitePlusiQ9HCE3.

Expressioni

Gene expression databases

BgeeiENSG00000074657.
CleanExiHS_ZNF532.
ExpressionAtlasiQ9HCE3. baseline and differential.
GenevisibleiQ9HCE3. HS.

Organism-specific databases

HPAiHPA015322.

Interactioni

Protein-protein interaction databases

BioGridi120501. 3 interactors.
IntActiQ9HCE3. 3 interactors.
STRINGi9606.ENSP00000338217.

Structurei

3D structure databases

ProteinModelPortaliQ9HCE3.
SMRiQ9HCE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri616 – 635C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri754 – 779C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri783 – 805C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri842 – 865C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri870 – 893C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri905 – 927C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri936 – 959C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1025 – 1048C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1055 – 1078C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1085 – 1111C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri1203 – 1226C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1264 – 1286C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063261.
HOGENOMiHOG000010306.
HOVERGENiHBG062228.
InParanoidiQ9HCE3.
OMAiFQSHVTK.
OrthoDBiEOG091G0AA1.
PhylomeDBiQ9HCE3.
TreeFamiTF329009.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF16622. zf-C2H2_11. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 15 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HCE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMGDMKTPD FDDLLAAFDI PDMVDPKAAI ESGHDDHESH MKQNAHGEDD
60 70 80 90 100
SHAPSSSDVG VSVIVKNVRN IDSSEGGEKD GHNPTGNGLH NGFLTASSLD
110 120 130 140 150
SYSKDGAKSL KGDVPASEVT LKDSTFSQFS PISSAEEFDD DEKIEVDDPP
160 170 180 190 200
DKEDMRSSFR SNVLTGSAPQ QDYDKLKALG GENSSKTGLS TSGNVEKNKA
210 220 230 240 250
VKRETEASSI NLSVYEPFKV RKAEDKLKES SDKVLENRVL DGKLSSEKND
260 270 280 290 300
TSLPSVAPSK TKSSSKLSSC IAAIAALSAK KAASDSCKEP VANSRESSPL
310 320 330 340 350
PKEVNDSPRA ADKSPESQNL IDGTKKPSLK QPDSPRSISS ENSSKGSPSS
360 370 380 390 400
PAGSTPAIPK VRIKTIKTSS GEIKRTVTRV LPEVDLDSGK KPSEQTASVM
410 420 430 440 450
ASVTSLLSSP ASAAVLSSPP RAPLQSAVVT NAVSPAELTP KQVTIKPVAT
460 470 480 490 500
AFLPVSAVKT AGSQVINLKL ANNTTVKATV ISAASVQSAS SAIIKAANAI
510 520 530 540 550
QQQTVVVPAS SLANAKLVPK TVHLANLNLL PQGAQATSEL RQVLTKPQQQ
560 570 580 590 600
IKQAIINAAA SQPPKKVSRV QVVSSLQSSV VEAFNKVLSS VNPVPVYIPN
610 620 630 640 650
LSPPANAGIT LPTRGYKCLE CGDSFALEKS LTQHYDRRSV RIEVTCNHCT
660 670 680 690 700
KNLVFYNKCS LLSHARGHKE KGVVMQCSHL ILKPVPADQM IVSPSSNTST
710 720 730 740 750
STSTLQSPVG AGTHTVTKIQ SGITGTVISA PSSTPITPAM PLDEDPSKLC
760 770 780 790 800
RHSLKCLECN EVFQDETSLA THFQQAADTS GQKTCTICQM LLPNQCSYAS
810 820 830 840 850
HQRIHQHKSP YTCPECGAIC RSVHFQTHVT KNCLHYTRRV GFRCVHCNVV
860 870 880 890 900
YSDVAALKSH IQGSHCEVFY KCPICPMAFK SAPSTHSHAY TQHPGIKIGE
910 920 930 940 950
PKIIYKCSMC DTVFTLQTLL YRHFDQHIEN QKVSVFKCPD CSLLYAQKQL
960 970 980 990 1000
MMDHIKSMHG TLKSIEGPPN LGINLPLSIK PATQNSANQN KEDTKSMNGK
1010 1020 1030 1040 1050
EKLEKKSPSP VKKSMETKKV ASPGWTCWEC DCLFMQRDVY ISHVRKEHGK
1060 1070 1080 1090 1100
QMKKHPCRQC DKSFSSSHSL CRHNRIKHKG IRKVYACSHC PDSRRTFTKR
1110 1120 1130 1140 1150
LMLEKHVQLM HGIKDPDLKE MTDATNEEET EIKEDTKVPS PKRKLEEPVL
1160 1170 1180 1190 1200
EFRPPRGAIT QPLKKLKINV FKVHKCAVCG FTTENLLQFH EHIPQHKSDG
1210 1220 1230 1240 1250
SSYQCRECGL CYTSHVSLSR HLFIVHKLKE PQPVSKQNGA GEDNQQENKP
1260 1270 1280 1290 1300
SHEDESPDGA VSDRKCKVCA KTFETEAALN THMRTHGMAF IKSKRMSSAE

K
Length:1,301
Mass (Da):141,696
Last modified:September 11, 2007 - v2
Checksum:i434E9519D144904A
GO

Sequence cautioni

The sequence AAH36366 differs from that shown. Reason: Frameshift at position 1077.Curated
The sequence BAA91755 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB13455 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti972G → S in AAH36366 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034846761E → D.Corresponds to variant rs3737506dbSNPEnsembl.1
Natural variantiVAR_035585822S → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs771503724dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039256 mRNA. Translation: AAK72122.1.
AB046849 mRNA. Translation: BAB13455.1. Different initiation.
BC036366 mRNA. Translation: AAH36366.1. Frameshift.
BC130618 mRNA. Translation: AAI30619.1.
BC130620 mRNA. Translation: AAI30621.1.
AK001559 mRNA. Translation: BAA91755.1. Different initiation.
CCDSiCCDS11969.1.
RefSeqiNP_001305655.1. NM_001318726.1.
NP_001305656.1. NM_001318727.1.
NP_001305657.1. NM_001318728.1.
NP_060651.2. NM_018181.5.
XP_016881301.1. XM_017025812.1.
XP_016881302.1. XM_017025813.1.
XP_016881303.1. XM_017025814.1.
XP_016881304.1. XM_017025815.1.
XP_016881305.1. XM_017025816.1.
XP_016881306.1. XM_017025817.1.
XP_016881307.1. XM_017025818.1.
UniGeneiHs.529023.
Hs.607676.

Genome annotation databases

EnsembliENST00000336078; ENSP00000338217; ENSG00000074657.
ENST00000589288; ENSP00000466007; ENSG00000074657.
ENST00000591083; ENSP00000468532; ENSG00000074657.
ENST00000591230; ENSP00000465709; ENSG00000074657.
ENST00000591808; ENSP00000468238; ENSG00000074657.
GeneIDi55205.
KEGGihsa:55205.
UCSCiuc002lho.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039256 mRNA. Translation: AAK72122.1.
AB046849 mRNA. Translation: BAB13455.1. Different initiation.
BC036366 mRNA. Translation: AAH36366.1. Frameshift.
BC130618 mRNA. Translation: AAI30619.1.
BC130620 mRNA. Translation: AAI30621.1.
AK001559 mRNA. Translation: BAA91755.1. Different initiation.
CCDSiCCDS11969.1.
RefSeqiNP_001305655.1. NM_001318726.1.
NP_001305656.1. NM_001318727.1.
NP_001305657.1. NM_001318728.1.
NP_060651.2. NM_018181.5.
XP_016881301.1. XM_017025812.1.
XP_016881302.1. XM_017025813.1.
XP_016881303.1. XM_017025814.1.
XP_016881304.1. XM_017025815.1.
XP_016881305.1. XM_017025816.1.
XP_016881306.1. XM_017025817.1.
XP_016881307.1. XM_017025818.1.
UniGeneiHs.529023.
Hs.607676.

3D structure databases

ProteinModelPortaliQ9HCE3.
SMRiQ9HCE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120501. 3 interactors.
IntActiQ9HCE3. 3 interactors.
STRINGi9606.ENSP00000338217.

PTM databases

iPTMnetiQ9HCE3.
PhosphoSitePlusiQ9HCE3.

Polymorphism and mutation databases

BioMutaiZNF532.
DMDMi158564020.

Proteomic databases

EPDiQ9HCE3.
MaxQBiQ9HCE3.
PaxDbiQ9HCE3.
PeptideAtlasiQ9HCE3.
PRIDEiQ9HCE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336078; ENSP00000338217; ENSG00000074657.
ENST00000589288; ENSP00000466007; ENSG00000074657.
ENST00000591083; ENSP00000468532; ENSG00000074657.
ENST00000591230; ENSP00000465709; ENSG00000074657.
ENST00000591808; ENSP00000468238; ENSG00000074657.
GeneIDi55205.
KEGGihsa:55205.
UCSCiuc002lho.4. human.

Organism-specific databases

CTDi55205.
DisGeNETi55205.
GeneCardsiZNF532.
HGNCiHGNC:30940. ZNF532.
HPAiHPA015322.
neXtProtiNX_Q9HCE3.
OpenTargetsiENSG00000074657.
PharmGKBiPA134901858.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063261.
HOGENOMiHOG000010306.
HOVERGENiHBG062228.
InParanoidiQ9HCE3.
OMAiFQSHVTK.
OrthoDBiEOG091G0AA1.
PhylomeDBiQ9HCE3.
TreeFamiTF329009.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000074657-MONOMER.

Miscellaneous databases

ChiTaRSiZNF532. human.
GenomeRNAii55205.
PROiQ9HCE3.

Gene expression databases

BgeeiENSG00000074657.
CleanExiHS_ZNF532.
ExpressionAtlasiQ9HCE3. baseline and differential.
GenevisibleiQ9HCE3. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF16622. zf-C2H2_11. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 15 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN532_HUMAN
AccessioniPrimary (citable) accession number: Q9HCE3
Secondary accession number(s): Q4G0V6
, Q7L7Z7, Q96QR7, Q9NVJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.