Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative helicase MOV-10

Gene

MOV10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC.3 Publications
(Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi524 – 531ATPBy similarity8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • helicase activity Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

RNA-mediated gene silencing, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155363-MONOMER.
ReactomeiR-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1912408. Pre-NOTCH Transcription and Translation.
R-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2559585. Oncogene Induced Senescence.
R-HSA-4086398. Ca2+ pathway.
R-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-5687128. MAPK6/MAPK4 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative helicase MOV-10 (EC:3.6.4.13)
Alternative name(s):
Armitage homolog1 Publication
Moloney leukemia virus 10 protein
Gene namesi
Name:MOV10
Synonyms:KIAA1631
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7200. MOV10.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic mRNA processing body Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi4343.
OpenTargetsiENSG00000155363.
PharmGKBiPA30908.

Polymorphism and mutation databases

DMDMi24638063.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000807041 – 1003Putative helicase MOV-10Add BLAST1003

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei148N6-acetyllysineCombined sources1
Modified residuei160PhosphothreonineCombined sources1
Modified residuei254PhosphothreonineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei969PhosphoserineCombined sources1
Modified residuei977PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9HCE1.
MaxQBiQ9HCE1.
PaxDbiQ9HCE1.
PeptideAtlasiQ9HCE1.
PRIDEiQ9HCE1.

PTM databases

iPTMnetiQ9HCE1.
PhosphoSitePlusiQ9HCE1.

Expressioni

Gene expression databases

BgeeiENSG00000155363.
CleanExiHS_MOV10.
ExpressionAtlasiQ9HCE1. baseline and differential.
GenevisibleiQ9HCE1. HS.

Interactioni

Subunit structurei

Interacts with DICER1, AGO2, TARBP2, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (PubMed:17507929). Interacts with APOBEC3G in an RNA-dependent manner.3 Publications
(Microbial infection) Interacts with the human hepatitis delta virus (HDV) antigen HDAg.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF2AK2P195252EBI-1055820,EBI-640775

Protein-protein interaction databases

BioGridi110484. 1008 interactors.
DIPiDIP-44158N.
IntActiQ9HCE1. 32 interactors.
MINTiMINT-4539786.
STRINGi9606.ENSP00000350028.

Structurei

3D structure databases

ProteinModelPortaliQ9HCE1.
SMRiQ9HCE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni921 – 965Interaction with AGO2 and APOBEC3G1 PublicationAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi645 – 648DEAG box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1804. Eukaryota.
COG1112. LUCA.
GeneTreeiENSGT00800000124068.
HOGENOMiHOG000239755.
HOVERGENiHBG052500.
InParanoidiQ9HCE1.
KOiK18422.
OMAiYYDGELQ.
OrthoDBiEOG091G03T8.
PhylomeDBiQ9HCE1.
TreeFamiTF323999.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR026122. MOV-10.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10887:SF322. PTHR10887:SF322. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCE1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSKFSCRQL REAGQCFESF LVVRGLDMET DRERLRTIYN RDFKISFGTP
60 70 80 90 100
APGFSSMLYG MKIANLAYVT KTRVRFFRLD RWADVRFPEK RRMKLGSDIS
110 120 130 140 150
KHHKSLLAKI FYDRAEYLHG KHGVDVEVQG PHEARDGQLL IRLDLNRKEV
160 170 180 190 200
LTLRLRNGGT QSVTLTHLFP LCRTPQFAFY NEDQELPCPL GPGECYELHV
210 220 230 240 250
HCKTSFVGYF PATVLWELLG PGESGSEGAG TFYIARFLAA VAHSPLAAQL
260 270 280 290 300
KPMTPFKRTR ITGNPVVTNR IEEGERPDRA KGYDLELSMA LGTYYPPPRL
310 320 330 340 350
RQLLPMLLQG TSIFTAPKEI AEIKAQLETA LKWRNYEVKL RLLLHLEELQ
360 370 380 390 400
MEHDIRHYDL ESVPMTWDPV DQNPRLLTLE VPGVTESRPS VLRGDHLFAL
410 420 430 440 450
LSSETHQEDP ITYKGFVHKV ELDRVKLSFS MSLLSRFVDG LTFKVNFTFN
460 470 480 490 500
RQPLRVQHRA LELTGRWLLW PMLFPVAPRD VPLLPSDVKL KLYDRSLESN
510 520 530 540 550
PEQLQAMRHI VTGTTRPAPY IIFGPPGTGK TVTLVEAIKQ VVKHLPKAHI
560 570 580 590 600
LACAPSNSGA DLLCQRLRVH LPSSIYRLLA PSRDIRMVPE DIKPCCNWDA
610 620 630 640 650
KKGEYVFPAK KKLQEYRVLI TTLITAGRLV SAQFPIDHFT HIFIDEAGHC
660 670 680 690 700
MEPESLVAIA GLMEVKETGD PGGQLVLAGD PRQLGPVLRS PLTQKHGLGY
710 720 730 740 750
SLLERLLTYN SLYKKGPDGY DPQFITKLLR NYRSHPTILD IPNQLYYEGE
760 770 780 790 800
LQACADVVDR ERFCRWAGLP RQGFPIIFHG VMGKDEREGN SPSFFNPEEA
810 820 830 840 850
ATVTSYLKLL LAPSSKKGKA RLSPRSVGVI SPYRKQVEKI RYCITKLDRE
860 870 880 890 900
LRGLDDIKDL KVGSVEEFQG QERSVILIST VRSSQSFVQL DLDFNLGFLK
910 920 930 940 950
NPKRFNVAVT RAKALLIIVG NPLLLGHDPD WKVFLEFCKE NGGYTGCPFP
960 970 980 990 1000
AKLDLQQGQN LLQGLSKLSP STSGPHSHDY LPQEREGEGG LSLQVEPEWR

NEL
Length:1,003
Mass (Da):113,671
Last modified:November 1, 2002 - v2
Checksum:i28A8B3BF9B5B54FC
GO
Isoform 2 (identifier: Q9HCE1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     838-900: EKIRYCITKL...DLDFNLGFLK → RSSVTSKGGA...PGLLPGSLLH
     901-1003: Missing.

Note: No experimental confirmation available.
Show »
Length:900
Mass (Da):101,598
Checksum:i0CF3733285C48342
GO
Isoform 3 (identifier: Q9HCE1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-56: FGTPAPGFSS → LASSKSILQS
     57-1003: Missing.

Show »
Length:56
Mass (Da):6,546
Checksum:i5FAEB3C0DC2A00F6
GO

Sequence cautioni

The sequence BAB13457 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAB85000 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98D → N in AL833353 (PubMed:17974005).Curated1
Sequence conflicti248A → T in AL833353 (PubMed:17974005).Curated1
Sequence conflicti814S → T in AL833353 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03730547 – 56FGTPAPGFSS → LASSKSILQS in isoform 3. 1 Publication10
Alternative sequenceiVSP_03730657 – 1003Missing in isoform 3. 1 PublicationAdd BLAST947
Alternative sequenceiVSP_010943838 – 900EKIRY…LGFLK → RSSVTSKGGAPPPDGTSLIS RPLGRGSRSLGLCWLRISEE HQGQLPPPFVPQLPGLLPGS LLH in isoform 2. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_010944901 – 1003Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046851 mRNA. Translation: BAB13457.1. Sequence problems.
AK074174 mRNA. Translation: BAB85000.1. Different initiation.
AL833353 mRNA. No translation available.
AL603832 Genomic DNA. Translation: CAI14055.1.
BC002548 mRNA. Translation: AAH02548.1.
BC004499 mRNA. Translation: AAH04499.2.
BC009312 mRNA. Translation: AAH09312.1.
CCDSiCCDS853.1. [Q9HCE1-1]
RefSeqiNP_001123551.1. NM_001130079.2. [Q9HCE1-1]
NP_001273001.1. NM_001286072.1.
NP_001308253.1. NM_001321324.1. [Q9HCE1-1]
NP_066014.1. NM_020963.4. [Q9HCE1-1]
XP_005270926.1. XM_005270869.4.
XP_005270927.1. XM_005270870.4.
XP_016856807.1. XM_017001318.1.
UniGeneiHs.514941.

Genome annotation databases

EnsembliENST00000357443; ENSP00000350028; ENSG00000155363. [Q9HCE1-1]
ENST00000369645; ENSP00000358659; ENSG00000155363. [Q9HCE1-1]
ENST00000413052; ENSP00000399797; ENSG00000155363. [Q9HCE1-1]
GeneIDi4343.
KEGGihsa:4343.
UCSCiuc001ecn.5. human. [Q9HCE1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046851 mRNA. Translation: BAB13457.1. Sequence problems.
AK074174 mRNA. Translation: BAB85000.1. Different initiation.
AL833353 mRNA. No translation available.
AL603832 Genomic DNA. Translation: CAI14055.1.
BC002548 mRNA. Translation: AAH02548.1.
BC004499 mRNA. Translation: AAH04499.2.
BC009312 mRNA. Translation: AAH09312.1.
CCDSiCCDS853.1. [Q9HCE1-1]
RefSeqiNP_001123551.1. NM_001130079.2. [Q9HCE1-1]
NP_001273001.1. NM_001286072.1.
NP_001308253.1. NM_001321324.1. [Q9HCE1-1]
NP_066014.1. NM_020963.4. [Q9HCE1-1]
XP_005270926.1. XM_005270869.4.
XP_005270927.1. XM_005270870.4.
XP_016856807.1. XM_017001318.1.
UniGeneiHs.514941.

3D structure databases

ProteinModelPortaliQ9HCE1.
SMRiQ9HCE1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110484. 1008 interactors.
DIPiDIP-44158N.
IntActiQ9HCE1. 32 interactors.
MINTiMINT-4539786.
STRINGi9606.ENSP00000350028.

PTM databases

iPTMnetiQ9HCE1.
PhosphoSitePlusiQ9HCE1.

Polymorphism and mutation databases

DMDMi24638063.

Proteomic databases

EPDiQ9HCE1.
MaxQBiQ9HCE1.
PaxDbiQ9HCE1.
PeptideAtlasiQ9HCE1.
PRIDEiQ9HCE1.

Protocols and materials databases

DNASUi4343.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357443; ENSP00000350028; ENSG00000155363. [Q9HCE1-1]
ENST00000369645; ENSP00000358659; ENSG00000155363. [Q9HCE1-1]
ENST00000413052; ENSP00000399797; ENSG00000155363. [Q9HCE1-1]
GeneIDi4343.
KEGGihsa:4343.
UCSCiuc001ecn.5. human. [Q9HCE1-1]

Organism-specific databases

CTDi4343.
DisGeNETi4343.
GeneCardsiMOV10.
HGNCiHGNC:7200. MOV10.
MIMi610742. gene.
neXtProtiNX_Q9HCE1.
OpenTargetsiENSG00000155363.
PharmGKBiPA30908.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1804. Eukaryota.
COG1112. LUCA.
GeneTreeiENSGT00800000124068.
HOGENOMiHOG000239755.
HOVERGENiHBG052500.
InParanoidiQ9HCE1.
KOiK18422.
OMAiYYDGELQ.
OrthoDBiEOG091G03T8.
PhylomeDBiQ9HCE1.
TreeFamiTF323999.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155363-MONOMER.
ReactomeiR-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1912408. Pre-NOTCH Transcription and Translation.
R-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2559585. Oncogene Induced Senescence.
R-HSA-4086398. Ca2+ pathway.
R-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-5687128. MAPK6/MAPK4 signaling.

Miscellaneous databases

ChiTaRSiMOV10. human.
GeneWikiiMOV10.
GenomeRNAii4343.
PROiQ9HCE1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155363.
CleanExiHS_MOV10.
ExpressionAtlasiQ9HCE1. baseline and differential.
GenevisibleiQ9HCE1. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR026122. MOV-10.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10887:SF322. PTHR10887:SF322. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOV10_HUMAN
AccessioniPrimary (citable) accession number: Q9HCE1
Secondary accession number(s): Q5JR03
, Q8TEF0, Q9BSY3, Q9BUJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.