Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative helicase MOV-10

Gene

MOV10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC.3 Publications
(Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi524 – 531ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processRNA-mediated gene silencing, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-4086398 Ca2+ pathway
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-8934593 Regulation of RUNX1 Expression and Activity
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8943723 Regulation of PTEN mRNA translation
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation
R-HSA-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Putative helicase MOV-10 (EC:3.6.4.13)
Alternative name(s):
Armitage homolog1 Publication
Moloney leukemia virus 10 protein
Gene namesi
Name:MOV10
Synonyms:KIAA1631
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000155363.18
HGNCiHGNC:7200 MOV10
MIMi610742 gene
neXtProtiNX_Q9HCE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi4343
OpenTargetsiENSG00000155363
PharmGKBiPA30908

Polymorphism and mutation databases

DMDMi24638063

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000807041 – 1003Putative helicase MOV-10Add BLAST1003

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei148N6-acetyllysineCombined sources1
Modified residuei160PhosphothreonineCombined sources1
Modified residuei254PhosphothreonineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei969PhosphoserineCombined sources1
Modified residuei977PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9HCE1
MaxQBiQ9HCE1
PaxDbiQ9HCE1
PeptideAtlasiQ9HCE1
PRIDEiQ9HCE1

PTM databases

CarbonylDBiQ9HCE1
iPTMnetiQ9HCE1
PhosphoSitePlusiQ9HCE1

Expressioni

Gene expression databases

BgeeiENSG00000155363
CleanExiHS_MOV10
ExpressionAtlasiQ9HCE1 baseline and differential
GenevisibleiQ9HCE1 HS

Organism-specific databases

HPAiHPA031627

Interactioni

Subunit structurei

Interacts with DICER1, AGO2, TARBP2, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (PubMed:17507929). Interacts with APOBEC3G in an RNA-dependent manner. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).4 Publications
(Microbial infection) Interacts with the human hepatitis delta virus (HDV) antigen HDAg.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110484, 1024 interactors
CORUMiQ9HCE1
DIPiDIP-44158N
IntActiQ9HCE1, 57 interactors
MINTiQ9HCE1
STRINGi9606.ENSP00000350028

Structurei

3D structure databases

ProteinModelPortaliQ9HCE1
SMRiQ9HCE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni921 – 965Interaction with AGO2 and APOBEC3G1 PublicationAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi645 – 648DEAG box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1804 Eukaryota
COG1112 LUCA
GeneTreeiENSGT00800000124068
HOGENOMiHOG000239755
HOVERGENiHBG052500
InParanoidiQ9HCE1
KOiK18422
OMAiYNPQFIT
OrthoDBiEOG091G03T8
PhylomeDBiQ9HCE1
TreeFamiTF323999

Family and domain databases

InterProiView protein in InterPro
IPR026122 MOV-10
IPR027417 P-loop_NTPase
PANTHERiPTHR10887:SF322 PTHR10887:SF322, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCE1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSKFSCRQL REAGQCFESF LVVRGLDMET DRERLRTIYN RDFKISFGTP
60 70 80 90 100
APGFSSMLYG MKIANLAYVT KTRVRFFRLD RWADVRFPEK RRMKLGSDIS
110 120 130 140 150
KHHKSLLAKI FYDRAEYLHG KHGVDVEVQG PHEARDGQLL IRLDLNRKEV
160 170 180 190 200
LTLRLRNGGT QSVTLTHLFP LCRTPQFAFY NEDQELPCPL GPGECYELHV
210 220 230 240 250
HCKTSFVGYF PATVLWELLG PGESGSEGAG TFYIARFLAA VAHSPLAAQL
260 270 280 290 300
KPMTPFKRTR ITGNPVVTNR IEEGERPDRA KGYDLELSMA LGTYYPPPRL
310 320 330 340 350
RQLLPMLLQG TSIFTAPKEI AEIKAQLETA LKWRNYEVKL RLLLHLEELQ
360 370 380 390 400
MEHDIRHYDL ESVPMTWDPV DQNPRLLTLE VPGVTESRPS VLRGDHLFAL
410 420 430 440 450
LSSETHQEDP ITYKGFVHKV ELDRVKLSFS MSLLSRFVDG LTFKVNFTFN
460 470 480 490 500
RQPLRVQHRA LELTGRWLLW PMLFPVAPRD VPLLPSDVKL KLYDRSLESN
510 520 530 540 550
PEQLQAMRHI VTGTTRPAPY IIFGPPGTGK TVTLVEAIKQ VVKHLPKAHI
560 570 580 590 600
LACAPSNSGA DLLCQRLRVH LPSSIYRLLA PSRDIRMVPE DIKPCCNWDA
610 620 630 640 650
KKGEYVFPAK KKLQEYRVLI TTLITAGRLV SAQFPIDHFT HIFIDEAGHC
660 670 680 690 700
MEPESLVAIA GLMEVKETGD PGGQLVLAGD PRQLGPVLRS PLTQKHGLGY
710 720 730 740 750
SLLERLLTYN SLYKKGPDGY DPQFITKLLR NYRSHPTILD IPNQLYYEGE
760 770 780 790 800
LQACADVVDR ERFCRWAGLP RQGFPIIFHG VMGKDEREGN SPSFFNPEEA
810 820 830 840 850
ATVTSYLKLL LAPSSKKGKA RLSPRSVGVI SPYRKQVEKI RYCITKLDRE
860 870 880 890 900
LRGLDDIKDL KVGSVEEFQG QERSVILIST VRSSQSFVQL DLDFNLGFLK
910 920 930 940 950
NPKRFNVAVT RAKALLIIVG NPLLLGHDPD WKVFLEFCKE NGGYTGCPFP
960 970 980 990 1000
AKLDLQQGQN LLQGLSKLSP STSGPHSHDY LPQEREGEGG LSLQVEPEWR

NEL
Length:1,003
Mass (Da):113,671
Last modified:November 1, 2002 - v2
Checksum:i28A8B3BF9B5B54FC
GO
Isoform 2 (identifier: Q9HCE1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     838-900: EKIRYCITKL...DLDFNLGFLK → RSSVTSKGGA...PGLLPGSLLH
     901-1003: Missing.

Note: No experimental confirmation available.
Show »
Length:900
Mass (Da):101,598
Checksum:i0CF3733285C48342
GO
Isoform 3 (identifier: Q9HCE1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-56: FGTPAPGFSS → LASSKSILQS
     57-1003: Missing.

Show »
Length:56
Mass (Da):6,546
Checksum:i5FAEB3C0DC2A00F6
GO

Sequence cautioni

The sequence BAB13457 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAB85000 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98D → N in AL833353 (PubMed:17974005).Curated1
Sequence conflicti248A → T in AL833353 (PubMed:17974005).Curated1
Sequence conflicti814S → T in AL833353 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03730547 – 56FGTPAPGFSS → LASSKSILQS in isoform 3. 1 Publication10
Alternative sequenceiVSP_03730657 – 1003Missing in isoform 3. 1 PublicationAdd BLAST947
Alternative sequenceiVSP_010943838 – 900EKIRY…LGFLK → RSSVTSKGGAPPPDGTSLIS RPLGRGSRSLGLCWLRISEE HQGQLPPPFVPQLPGLLPGS LLH in isoform 2. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_010944901 – 1003Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046851 mRNA Translation: BAB13457.1 Sequence problems.
AK074174 mRNA Translation: BAB85000.1 Different initiation.
AL833353 mRNA No translation available.
AL603832 Genomic DNA No translation available.
BC002548 mRNA Translation: AAH02548.1
BC004499 mRNA Translation: AAH04499.2
BC009312 mRNA Translation: AAH09312.1
CCDSiCCDS853.1 [Q9HCE1-1]
RefSeqiNP_001123551.1, NM_001130079.2 [Q9HCE1-1]
NP_001273001.1, NM_001286072.1
NP_001308253.1, NM_001321324.1 [Q9HCE1-1]
NP_066014.1, NM_020963.4 [Q9HCE1-1]
XP_005270926.1, XM_005270869.4
XP_005270927.1, XM_005270870.4
XP_016856807.1, XM_017001318.1
UniGeneiHs.514941

Genome annotation databases

EnsembliENST00000357443; ENSP00000350028; ENSG00000155363 [Q9HCE1-1]
ENST00000369645; ENSP00000358659; ENSG00000155363 [Q9HCE1-1]
ENST00000413052; ENSP00000399797; ENSG00000155363 [Q9HCE1-1]
GeneIDi4343
KEGGihsa:4343
UCSCiuc001ecn.5 human [Q9HCE1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMOV10_HUMAN
AccessioniPrimary (citable) accession number: Q9HCE1
Secondary accession number(s): Q5JR03
, Q8TEF0, Q9BSY3, Q9BUJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: May 23, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health