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Protein

Protein TANC2

Gene

TANC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TANC2
Alternative name(s):
Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2
Gene namesi
Name:TANC2
Synonyms:KIAA1148, KIAA1636
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30212. TANC2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670837.

Polymorphism and mutation databases

BioMutaiTANC2.
DMDMi189029946.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19901990Protein TANC2PRO_0000333811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei169 – 1691PhosphoserineCombined sources
Modified residuei238 – 2381PhosphoserineCombined sources
Modified residuei294 – 2941PhosphoserineCombined sources
Modified residuei400 – 4001PhosphoserineCombined sources
Modified residuei1442 – 14421PhosphoserineCombined sources
Modified residuei1458 – 14581PhosphoserineCombined sources
Modified residuei1530 – 15301PhosphoserineCombined sources
Modified residuei1545 – 15451PhosphoserineCombined sources
Modified residuei1579 – 15791PhosphoserineCombined sources
Modified residuei1722 – 17221PhosphoserineCombined sources
Modified residuei1824 – 18241PhosphoserineBy similarity
Modified residuei1827 – 18271PhosphoserineCombined sources
Glycosylationi1928 – 19281N-linked (GlcNAc...)By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9HCD6.
MaxQBiQ9HCD6.
PaxDbiQ9HCD6.
PeptideAtlasiQ9HCD6.
PRIDEiQ9HCD6.

PTM databases

iPTMnetiQ9HCD6.
PhosphoSiteiQ9HCD6.

Expressioni

Gene expression databases

BgeeiQ9HCD6.
CleanExiHS_TANC2.
ExpressionAtlasiQ9HCD6. baseline and differential.
GenevisibleiQ9HCD6. HS.

Organism-specific databases

HPAiHPA023274.

Interactioni

Protein-protein interaction databases

BioGridi117559. 13 interactions.
IntActiQ9HCD6. 9 interactions.
MINTiMINT-7945062.
STRINGi9606.ENSP00000387593.

Structurei

3D structure databases

ProteinModelPortaliQ9HCD6.
SMRiQ9HCD6. Positions 855-1360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati846 – 87833ANK 1Add
BLAST
Repeati884 – 91330ANK 2Add
BLAST
Repeati917 – 94630ANK 3Add
BLAST
Repeati950 – 97930ANK 4Add
BLAST
Repeati990 – 101930ANK 5Add
BLAST
Repeati1033 – 106230ANK 6Add
BLAST
Repeati1066 – 109530ANK 7Add
BLAST
Repeati1099 – 112830ANK 8Add
BLAST
Repeati1132 – 116130ANK 9Add
BLAST
Repeati1165 – 119430ANK 10Add
BLAST
Repeati1198 – 122730ANK 11Add
BLAST
Repeati1244 – 127734TPR 1Add
BLAST
Repeati1291 – 132434TPR 2Add
BLAST
Repeati1325 – 135834TPR 3Add
BLAST

Sequence similaritiesi

Belongs to the TANC family.Curated
Contains 11 ANK repeats.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000231045.
HOVERGENiHBG061464.
InParanoidiQ9HCD6.
OMAiITQRISP.
OrthoDBiEOG786H29.
PhylomeDBiQ9HCD6.
TreeFamiTF323159.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR027417. P-loop_NTPase.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
PF13181. TPR_8. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCD6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRNSLKMLL TGGKSSRKNR SSDGGSEEPP DRRQSSVDSR QSRSGQGGIS
60 70 80 90 100
TESDCAFEPD YAVPPLPVSE GDAEQELGPP PSVDEAANTL MTRLGFLLGE
110 120 130 140 150
KVTEVQPGDQ YSMEVQDENQ TSAITQRISP CSTLTSSTAS PPASSPCSTL
160 170 180 190 200
PPISTNATAK DCSYGAVTSP TSTLESRDSG IIATLTSYSE NVERTKYAGE
210 220 230 240 250
SSKELGSGGN IKPWQSQKSS MDSCLYRVDE NMTASTYSLN KIPERNLETV
260 270 280 290 300
LSQSVQSIPL YLMPRPNSVA ATSSAHLEDL AYLDEQRHTP LRTSLRMPRQ
310 320 330 340 350
SMGGARTQQD LRVRFAPYRP PDISLKPLLF EVPSITTESV FVGRDWVFHE
360 370 380 390 400
IDAQLQSSNA SVNQGVVIVG NIGFGKTAII SRLVALSCHG TRMRQIASDS
410 420 430 440 450
PHASPKHVDA NRELPLTQPP SAHSSITSGS CPGTPEMRRR QEEAMRRLAS
460 470 480 490 500
QVVAYHYCQA DNAYTCLVPE FVHNVAALLC RSPQLTAYRE QLLREPHLQS
510 520 530 540 550
MLSLRSCVQD PMASFRRGVL EPLENLHKER KIPDEDFIIL IDGLNEAEFH
560 570 580 590 600
KPDYGDTIVS FLSKMIGKFP SWLKLIVTVR TSLQEITKLL PFHRIFLDRL
610 620 630 640 650
EENEAIDQDL QAYILHRIHS SSEIQNNISL NGKMDNTTFG KLSSHLKTLS
660 670 680 690 700
QGSYLYLKLT FDLIEKGYLV LKSSSYKVVP VSLSEVYLLQ CNMKFPTQSS
710 720 730 740 750
FDRVMPLLNV AVASLHPLTD EHIFQAINAG SIEGTLEWED FQQRMENLSM
760 770 780 790 800
FLIKRRDMTR MFVHPSFREW LIWREEGEKT KFLCDPRSGH TLLAFWFSRQ
810 820 830 840 850
EGKLNRQQTI ELGHHILKAH IFKGLSKKVG VSSSILQGLW ISYSTEGLSM
860 870 880 890 900
ALASLRNLYT PNIKVSRLLI LGGANINYRT EVLNNAPILC VQSHLGYTEM
910 920 930 940 950
VALLLEFGAN VDASSESGLT PLGYAAAAGY LSIVVLLCKK RAKVDHLDKN
960 970 980 990 1000
GQCALVHAAL RGHLEVVKFL IQCDWTMAGQ QQGVFKKSHA IQQALIAAAS
1010 1020 1030 1040 1050
MGYTEIVSYL LDLPEKDEEE VERAQINSFD SLWGETALTA AAGRGKLEVC
1060 1070 1080 1090 1100
RLLLEQGAAV AQPNRRGAVP LFSTVRQGHW QIVDLLLTHG ADVNMADKQG
1110 1120 1130 1140 1150
RTPLMMAASE GHLGTVDFLL AQGASIALMD KEGLTALSWA CLKGHLSVVR
1160 1170 1180 1190 1200
SLVDNGAATD HADKNGRTPL DLAAFYGDAE VVQFLVDHGA MIEHVDYSGM
1210 1220 1230 1240 1250
RPLDRAVGCR NTSVVVTLLK KGAKIGPATW AMATSKPDIM IILLSKLMEE
1260 1270 1280 1290 1300
GDMFYKKGKV KEAAQRYQYA LKKFPREGFG EDLKTFRELK VSLLLNLSRC
1310 1320 1330 1340 1350
RRKMNDFGMA EEFATKALEL KPKSYEAYYA RARAKRSSRQ FAAALEDLNE
1360 1370 1380 1390 1400
AIKLCPNNRE IQRLLLRVEE ECRQMQQPQQ PPPPPQPQQQ LPEEAEPEPQ
1410 1420 1430 1440 1450
HEDIYSVQDI FEEEYLEQDV ENVSIGLQTE ARPSQGLPVI QSPPSSPPHR
1460 1470 1480 1490 1500
DSAYISSSPL GSHQVFDFRS SSSVGSPTRQ TYQSTSPALS PTHQNSHYRP
1510 1520 1530 1540 1550
SPPHTSPAHQ GGSYRFSPPP VGGQGKEYPS PPPSPLRRGP QYRASPPAES
1560 1570 1580 1590 1600
MSVYRSQSGS PVRYQQETSV SQLPGRPKSP LSKMAQRPYQ MPQLPVAVPQ
1610 1620 1630 1640 1650
QGLRLQPAKA QIVRSNQPSP AVHSSTVIPT GAYGQVAHSM ASKYQSSQGD
1660 1670 1680 1690 1700
IGVSQSRLVY QGSIGGIVGD GRPVQHVQAS LSAGAICQHG GLTKEDLPQR
1710 1720 1730 1740 1750
PSSAYRGGVR YSQTPQIGRS QSASYYPVCH SKLDLERSSS QLGSPDVSHL
1760 1770 1780 1790 1800
IRRPISVNPN EIKPHPPTPR PLLHSQSVGL RFSPSSNSIS STSNLTPTFR
1810 1820 1830 1840 1850
PSSSIQQMEI PLKPAYERSC DELSPVSPTQ GGYPSEPTRS RTTPFMGIID
1860 1870 1880 1890 1900
KTARTQQYPH LHQQNRTWAV SSVDTVLSPT SPGNLPQPES FSPPSSISNI
1910 1920 1930 1940 1950
AFYNKTNNAQ NGHLLEDDYY SPHGMLANGS RGDLLERVSQ ASSYPDVKVA
1960 1970 1980 1990
RTLPVAQAYQ DNLYRQLSRD SRQGQTSPIK PKRPFVESNV
Length:1,990
Mass (Da):219,650
Last modified:May 20, 2008 - v3
Checksum:iE835D98F5C546365
GO
Isoform 2 (identifier: Q9HCD6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1225-1225: I → IGCQTLPSRPR

Show »
Length:2,000
Mass (Da):220,746
Checksum:iCABC5E9427E0AB68
GO
Isoform 3 (identifier: Q9HCD6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     944-971: VDHLDKNGQCALVHAALRGHLEVVKFLI → VLAAQLCCFSSLFLYFRCILFLISSVTS
     972-1990: Missing.

Note: No experimental confirmation available.
Show »
Length:971
Mass (Da):107,895
Checksum:iA081DBE1D3316880
GO
Isoform 4 (identifier: Q9HCD6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1006-1010: IVSYL → VRSRQ
     1011-1990: Missing.

Note: No experimental confirmation available.
Show »
Length:1,010
Mass (Da):112,154
Checksum:i38BFC3EE8DD7BD26
GO

Sequence cautioni

The sequence CAB92314.1 differs from that shown. Reason: Frameshift at position 1221. Curated
Isoform 2 : The sequence CAB92314.1 differs from that shown. Reason: Frameshift at position 363. Curated
The sequence CAB92314.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1210 – 12101R → P in CAB92314 (Ref. 4) Curated
Sequence conflicti1234 – 12341T → P in CAB92314 (Ref. 4) Curated
Sequence conflicti1249 – 12491E → K in CAB92314 (Ref. 4) Curated
Sequence conflicti1285 – 12851T → P in CAB92314 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti760 – 7601R → C Found in a patient with intra-uterine growth retardation, no speech, fever convulsions and low IgA and IgG levels. 1 Publication
VAR_069374

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei944 – 97128VDHLD…VKFLI → VLAAQLCCFSSLFLYFRCIL FLISSVTS in isoform 3. 1 PublicationVSP_033546Add
BLAST
Alternative sequencei972 – 19901019Missing in isoform 3. 1 PublicationVSP_033547Add
BLAST
Alternative sequencei1006 – 10105IVSYL → VRSRQ in isoform 4. 1 PublicationVSP_033548
Alternative sequencei1011 – 1990980Missing in isoform 4. 1 PublicationVSP_033549Add
BLAST
Alternative sequencei1225 – 12251I → IGCQTLPSRPR in isoform 2. 1 PublicationVSP_033550

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005828 Genomic DNA. No translation available.
AC005972 Genomic DNA. No translation available.
AC006270 Genomic DNA. No translation available.
AC015923 Genomic DNA. No translation available.
AB046856 mRNA. Translation: BAB13462.2.
AK001077 mRNA. No translation available.
AK021886 mRNA. No translation available.
AJ278120 mRNA. Translation: CAB92314.1. Sequence problems.
AB032974 mRNA. Translation: BAA86462.2.
CCDSiCCDS45754.1. [Q9HCD6-1]
RefSeqiNP_079461.2. NM_025185.3. [Q9HCD6-1]
XP_005257260.1. XM_005257203.3. [Q9HCD6-1]
UniGeneiHs.410889.

Genome annotation databases

EnsembliENST00000389520; ENSP00000374171; ENSG00000170921. [Q9HCD6-2]
ENST00000424789; ENSP00000387593; ENSG00000170921. [Q9HCD6-1]
GeneIDi26115.
KEGGihsa:26115.
UCSCiuc002jal.5. human. [Q9HCD6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005828 Genomic DNA. No translation available.
AC005972 Genomic DNA. No translation available.
AC006270 Genomic DNA. No translation available.
AC015923 Genomic DNA. No translation available.
AB046856 mRNA. Translation: BAB13462.2.
AK001077 mRNA. No translation available.
AK021886 mRNA. No translation available.
AJ278120 mRNA. Translation: CAB92314.1. Sequence problems.
AB032974 mRNA. Translation: BAA86462.2.
CCDSiCCDS45754.1. [Q9HCD6-1]
RefSeqiNP_079461.2. NM_025185.3. [Q9HCD6-1]
XP_005257260.1. XM_005257203.3. [Q9HCD6-1]
UniGeneiHs.410889.

3D structure databases

ProteinModelPortaliQ9HCD6.
SMRiQ9HCD6. Positions 855-1360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117559. 13 interactions.
IntActiQ9HCD6. 9 interactions.
MINTiMINT-7945062.
STRINGi9606.ENSP00000387593.

PTM databases

iPTMnetiQ9HCD6.
PhosphoSiteiQ9HCD6.

Polymorphism and mutation databases

BioMutaiTANC2.
DMDMi189029946.

Proteomic databases

EPDiQ9HCD6.
MaxQBiQ9HCD6.
PaxDbiQ9HCD6.
PeptideAtlasiQ9HCD6.
PRIDEiQ9HCD6.

Protocols and materials databases

DNASUi26115.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389520; ENSP00000374171; ENSG00000170921. [Q9HCD6-2]
ENST00000424789; ENSP00000387593; ENSG00000170921. [Q9HCD6-1]
GeneIDi26115.
KEGGihsa:26115.
UCSCiuc002jal.5. human. [Q9HCD6-1]

Organism-specific databases

CTDi26115.
GeneCardsiTANC2.
H-InvDBHIX0014063.
HGNCiHGNC:30212. TANC2.
HPAiHPA023274.
MIMi615047. gene.
neXtProtiNX_Q9HCD6.
PharmGKBiPA142670837.
HUGEiSearch...
Search...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000231045.
HOVERGENiHBG061464.
InParanoidiQ9HCD6.
OMAiITQRISP.
OrthoDBiEOG786H29.
PhylomeDBiQ9HCD6.
TreeFamiTF323159.

Miscellaneous databases

ChiTaRSiTANC2. human.
GenomeRNAii26115.
PROiQ9HCD6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HCD6.
CleanExiHS_TANC2.
ExpressionAtlasiQ9HCD6. baseline and differential.
GenevisibleiQ9HCD6. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR027417. P-loop_NTPase.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
PF13181. TPR_8. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-1990 (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 676-1990 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 843-1990 (ISOFORM 4).
    Tissue: Embryo.
  4. Dahllund L., Sjodin J., Wikstrom L.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 869-1990 (ISOFORM 2).
  5. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1448-1990 (ISOFORMS 1/2).
    Tissue: Brain.
  6. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
    Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
    Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1442, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; SER-238; SER-294; SER-400; SER-1458; SER-1530; SER-1545; SER-1579; SER-1722 AND SER-1827, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  13. Cited for: VARIANT CYS-760.

Entry informationi

Entry nameiTANC2_HUMAN
AccessioniPrimary (citable) accession number: Q9HCD6
Secondary accession number(s): Q9HAC3
, Q9NW88, Q9NXY9, Q9ULS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 6, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.