Q9HCD6 (TANC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein TANC2

Alternative name(s):
Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2

Gene names

Name:	TANC2
Synonyms:	KIAA1148, KIAA1636

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1990 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the TANC family. Contains 11 ANK repeats. Contains 3 TPR repeats.
Sequence caution	The sequence CAB92314.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAB92314.1 differs from that shown. Reason: Frameshift at position 1221. Isoform 2: The sequence CAB92314.1 differs from that shown. Reason: Frameshift at position 363.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat TPR repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HCD6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HCD6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1225-1225: I → IGCQTLPSRPR

Isoform 3 (identifier: Q9HCD6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     944-971: VDHLDKNGQCALVHAALRGHLEVVKFLI → VLAAQLCCFSSLFLYFRCILFLISSVTS
     972-1990: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9HCD6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1006-1010: IVSYL → VRSRQ
     1011-1990: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1990	1990	Protein TANC2		PRO_0000333811
Regions
	Repeat	846 – 878	33	ANK 1
	Repeat	884 – 913	30	ANK 2
	Repeat	917 – 946	30	ANK 3
	Repeat	950 – 979	30	ANK 4
	Repeat	990 – 1019	30	ANK 5
	Repeat	1033 – 1062	30	ANK 6
	Repeat	1066 – 1095	30	ANK 7
	Repeat	1099 – 1128	30	ANK 8
	Repeat	1132 – 1161	30	ANK 9
	Repeat	1165 – 1194	30	ANK 10
	Repeat	1198 – 1227	30	ANK 11
	Repeat	1244 – 1277	34	TPR 1
	Repeat	1291 – 1324	34	TPR 2
	Repeat	1325 – 1358	34	TPR 3
Amino acid modifications
	Modified residue	169	1	Phosphoserine Ref.7
	Modified residue	171	1	Phosphothreonine Ref.9
	Modified residue	1442	1	Phosphoserine Ref.6
	Modified residue	1446	1	Phosphoserine Ref.6
	Modified residue	1457	1	Phosphoserine Ref.8
	Modified residue	1530	1	Phosphoserine Ref.10
	Modified residue	1534	1	Phosphoserine Ref.10
	Modified residue	1545	1	Phosphoserine By similarity
	Modified residue	1827	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	944 – 971	28	VDHLD…VKFLI → VLAAQLCCFSSLFLYFRCIL FLISSVTS in isoform 3.		VSP_033546
	Alternative sequence	972 – 1990	1019	Missing in isoform 3.		VSP_033547
	Alternative sequence	1006 – 1010	5	IVSYL → VRSRQ in isoform 4.		VSP_033548
	Alternative sequence	1011 – 1990	980	Missing in isoform 4.		VSP_033549
	Alternative sequence	1225	1	I → IGCQTLPSRPR in isoform 2.		VSP_033550
Experimental info
	Sequence conflict	1210	1	R → P in CAB92314. Ref.4
	Sequence conflict	1234	1	T → P in CAB92314. Ref.4
	Sequence conflict	1249	1	E → K in CAB92314. Ref.4
	Sequence conflict	1285	1	T → P in CAB92314. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 20, 2008. Version 3. Checksum: E835D98F5C546365	FASTA	1,990	219,650
	10 20 30 40 50 60 MFRNSLKMLL TGGKSSRKNR SSDGGSEEPP DRRQSSVDSR QSRSGQGGIS TESDCAFEPD 70 80 90 100 110 120 YAVPPLPVSE GDAEQELGPP PSVDEAANTL MTRLGFLLGE KVTEVQPGDQ YSMEVQDENQ 130 140 150 160 170 180 TSAITQRISP CSTLTSSTAS PPASSPCSTL PPISTNATAK DCSYGAVTSP TSTLESRDSG 190 200 210 220 230 240 IIATLTSYSE NVERTKYAGE SSKELGSGGN IKPWQSQKSS MDSCLYRVDE NMTASTYSLN 250 260 270 280 290 300 KIPERNLETV LSQSVQSIPL YLMPRPNSVA ATSSAHLEDL AYLDEQRHTP LRTSLRMPRQ 310 320 330 340 350 360 SMGGARTQQD LRVRFAPYRP PDISLKPLLF EVPSITTESV FVGRDWVFHE IDAQLQSSNA 370 380 390 400 410 420 SVNQGVVIVG NIGFGKTAII SRLVALSCHG TRMRQIASDS PHASPKHVDA NRELPLTQPP 430 440 450 460 470 480 SAHSSITSGS CPGTPEMRRR QEEAMRRLAS QVVAYHYCQA DNAYTCLVPE FVHNVAALLC 490 500 510 520 530 540 RSPQLTAYRE QLLREPHLQS MLSLRSCVQD PMASFRRGVL EPLENLHKER KIPDEDFIIL 550 560 570 580 590 600 IDGLNEAEFH KPDYGDTIVS FLSKMIGKFP SWLKLIVTVR TSLQEITKLL PFHRIFLDRL 610 620 630 640 650 660 EENEAIDQDL QAYILHRIHS SSEIQNNISL NGKMDNTTFG KLSSHLKTLS QGSYLYLKLT 670 680 690 700 710 720 FDLIEKGYLV LKSSSYKVVP VSLSEVYLLQ CNMKFPTQSS FDRVMPLLNV AVASLHPLTD 730 740 750 760 770 780 EHIFQAINAG SIEGTLEWED FQQRMENLSM FLIKRRDMTR MFVHPSFREW LIWREEGEKT 790 800 810 820 830 840 KFLCDPRSGH TLLAFWFSRQ EGKLNRQQTI ELGHHILKAH IFKGLSKKVG VSSSILQGLW 850 860 870 880 890 900 ISYSTEGLSM ALASLRNLYT PNIKVSRLLI LGGANINYRT EVLNNAPILC VQSHLGYTEM 910 920 930 940 950 960 VALLLEFGAN VDASSESGLT PLGYAAAAGY LSIVVLLCKK RAKVDHLDKN GQCALVHAAL 970 980 990 1000 1010 1020 RGHLEVVKFL IQCDWTMAGQ QQGVFKKSHA IQQALIAAAS MGYTEIVSYL LDLPEKDEEE 1030 1040 1050 1060 1070 1080 VERAQINSFD SLWGETALTA AAGRGKLEVC RLLLEQGAAV AQPNRRGAVP LFSTVRQGHW 1090 1100 1110 1120 1130 1140 QIVDLLLTHG ADVNMADKQG RTPLMMAASE GHLGTVDFLL AQGASIALMD KEGLTALSWA 1150 1160 1170 1180 1190 1200 CLKGHLSVVR SLVDNGAATD HADKNGRTPL DLAAFYGDAE VVQFLVDHGA MIEHVDYSGM 1210 1220 1230 1240 1250 1260 RPLDRAVGCR NTSVVVTLLK KGAKIGPATW AMATSKPDIM IILLSKLMEE GDMFYKKGKV 1270 1280 1290 1300 1310 1320 KEAAQRYQYA LKKFPREGFG EDLKTFRELK VSLLLNLSRC RRKMNDFGMA EEFATKALEL 1330 1340 1350 1360 1370 1380 KPKSYEAYYA RARAKRSSRQ FAAALEDLNE AIKLCPNNRE IQRLLLRVEE ECRQMQQPQQ 1390 1400 1410 1420 1430 1440 PPPPPQPQQQ LPEEAEPEPQ HEDIYSVQDI FEEEYLEQDV ENVSIGLQTE ARPSQGLPVI 1450 1460 1470 1480 1490 1500 QSPPSSPPHR DSAYISSSPL GSHQVFDFRS SSSVGSPTRQ TYQSTSPALS PTHQNSHYRP 1510 1520 1530 1540 1550 1560 SPPHTSPAHQ GGSYRFSPPP VGGQGKEYPS PPPSPLRRGP QYRASPPAES MSVYRSQSGS 1570 1580 1590 1600 1610 1620 PVRYQQETSV SQLPGRPKSP LSKMAQRPYQ MPQLPVAVPQ QGLRLQPAKA QIVRSNQPSP 1630 1640 1650 1660 1670 1680 AVHSSTVIPT GAYGQVAHSM ASKYQSSQGD IGVSQSRLVY QGSIGGIVGD GRPVQHVQAS 1690 1700 1710 1720 1730 1740 LSAGAICQHG GLTKEDLPQR PSSAYRGGVR YSQTPQIGRS QSASYYPVCH SKLDLERSSS 1750 1760 1770 1780 1790 1800 QLGSPDVSHL IRRPISVNPN EIKPHPPTPR PLLHSQSVGL RFSPSSNSIS STSNLTPTFR 1810 1820 1830 1840 1850 1860 PSSSIQQMEI PLKPAYERSC DELSPVSPTQ GGYPSEPTRS RTTPFMGIID KTARTQQYPH 1870 1880 1890 1900 1910 1920 LHQQNRTWAV SSVDTVLSPT SPGNLPQPES FSPPSSISNI AFYNKTNNAQ NGHLLEDDYY 1930 1940 1950 1960 1970 1980 SPHGMLANGS RGDLLERVSQ ASSYPDVKVA RTLPVAQAYQ DNLYRQLSRD SRQGQTSPIK 1990 PKRPFVESNV
	Isoform 2 [UniParc]. Checksum: CABC5E9427E0AB68	FASTA	2,000	220,746
	10 20 30 40 50 60 MFRNSLKMLL TGGKSSRKNR SSDGGSEEPP DRRQSSVDSR QSRSGQGGIS TESDCAFEPD 70 80 90 100 110 120 YAVPPLPVSE GDAEQELGPP PSVDEAANTL MTRLGFLLGE KVTEVQPGDQ YSMEVQDENQ 130 140 150 160 170 180 TSAITQRISP CSTLTSSTAS PPASSPCSTL PPISTNATAK DCSYGAVTSP TSTLESRDSG 190 200 210 220 230 240 IIATLTSYSE NVERTKYAGE SSKELGSGGN IKPWQSQKSS MDSCLYRVDE NMTASTYSLN 250 260 270 280 290 300 KIPERNLETV LSQSVQSIPL YLMPRPNSVA ATSSAHLEDL AYLDEQRHTP LRTSLRMPRQ 310 320 330 340 350 360 SMGGARTQQD LRVRFAPYRP PDISLKPLLF EVPSITTESV FVGRDWVFHE IDAQLQSSNA 370 380 390 400 410 420 SVNQGVVIVG NIGFGKTAII SRLVALSCHG TRMRQIASDS PHASPKHVDA NRELPLTQPP 430 440 450 460 470 480 SAHSSITSGS CPGTPEMRRR QEEAMRRLAS QVVAYHYCQA DNAYTCLVPE FVHNVAALLC 490 500 510 520 530 540 RSPQLTAYRE QLLREPHLQS MLSLRSCVQD PMASFRRGVL EPLENLHKER KIPDEDFIIL 550 560 570 580 590 600 IDGLNEAEFH KPDYGDTIVS FLSKMIGKFP SWLKLIVTVR TSLQEITKLL PFHRIFLDRL 610 620 630 640 650 660 EENEAIDQDL QAYILHRIHS SSEIQNNISL NGKMDNTTFG KLSSHLKTLS QGSYLYLKLT 670 680 690 700 710 720 FDLIEKGYLV LKSSSYKVVP VSLSEVYLLQ CNMKFPTQSS FDRVMPLLNV AVASLHPLTD 730 740 750 760 770 780 EHIFQAINAG SIEGTLEWED FQQRMENLSM FLIKRRDMTR MFVHPSFREW LIWREEGEKT 790 800 810 820 830 840 KFLCDPRSGH TLLAFWFSRQ EGKLNRQQTI ELGHHILKAH IFKGLSKKVG VSSSILQGLW 850 860 870 880 890 900 ISYSTEGLSM ALASLRNLYT PNIKVSRLLI LGGANINYRT EVLNNAPILC VQSHLGYTEM 910 920 930 940 950 960 VALLLEFGAN VDASSESGLT PLGYAAAAGY LSIVVLLCKK RAKVDHLDKN GQCALVHAAL 970 980 990 1000 1010 1020 RGHLEVVKFL IQCDWTMAGQ QQGVFKKSHA IQQALIAAAS MGYTEIVSYL LDLPEKDEEE 1030 1040 1050 1060 1070 1080 VERAQINSFD SLWGETALTA AAGRGKLEVC RLLLEQGAAV AQPNRRGAVP LFSTVRQGHW 1090 1100 1110 1120 1130 1140 QIVDLLLTHG ADVNMADKQG RTPLMMAASE GHLGTVDFLL AQGASIALMD KEGLTALSWA 1150 1160 1170 1180 1190 1200 CLKGHLSVVR SLVDNGAATD HADKNGRTPL DLAAFYGDAE VVQFLVDHGA MIEHVDYSGM 1210 1220 1230 1240 1250 1260 RPLDRAVGCR NTSVVVTLLK KGAKIGCQTL PSRPRGPATW AMATSKPDIM IILLSKLMEE 1270 1280 1290 1300 1310 1320 GDMFYKKGKV KEAAQRYQYA LKKFPREGFG EDLKTFRELK VSLLLNLSRC RRKMNDFGMA 1330 1340 1350 1360 1370 1380 EEFATKALEL KPKSYEAYYA RARAKRSSRQ FAAALEDLNE AIKLCPNNRE IQRLLLRVEE 1390 1400 1410 1420 1430 1440 ECRQMQQPQQ PPPPPQPQQQ LPEEAEPEPQ HEDIYSVQDI FEEEYLEQDV ENVSIGLQTE 1450 1460 1470 1480 1490 1500 ARPSQGLPVI QSPPSSPPHR DSAYISSSPL GSHQVFDFRS SSSVGSPTRQ TYQSTSPALS 1510 1520 1530 1540 1550 1560 PTHQNSHYRP SPPHTSPAHQ GGSYRFSPPP VGGQGKEYPS PPPSPLRRGP QYRASPPAES 1570 1580 1590 1600 1610 1620 MSVYRSQSGS PVRYQQETSV SQLPGRPKSP LSKMAQRPYQ MPQLPVAVPQ QGLRLQPAKA 1630 1640 1650 1660 1670 1680 QIVRSNQPSP AVHSSTVIPT GAYGQVAHSM ASKYQSSQGD IGVSQSRLVY QGSIGGIVGD 1690 1700 1710 1720 1730 1740 GRPVQHVQAS LSAGAICQHG GLTKEDLPQR PSSAYRGGVR YSQTPQIGRS QSASYYPVCH 1750 1760 1770 1780 1790 1800 SKLDLERSSS QLGSPDVSHL IRRPISVNPN EIKPHPPTPR PLLHSQSVGL RFSPSSNSIS 1810 1820 1830 1840 1850 1860 STSNLTPTFR PSSSIQQMEI PLKPAYERSC DELSPVSPTQ GGYPSEPTRS RTTPFMGIID 1870 1880 1890 1900 1910 1920 KTARTQQYPH LHQQNRTWAV SSVDTVLSPT SPGNLPQPES FSPPSSISNI AFYNKTNNAQ 1930 1940 1950 1960 1970 1980 NGHLLEDDYY SPHGMLANGS RGDLLERVSQ ASSYPDVKVA RTLPVAQAYQ DNLYRQLSRD 1990 2000 SRQGQTSPIK PKRPFVESNV
	Isoform 3 [UniParc]. Checksum: A081DBE1D3316880	FASTA	971	107,895
	10 20 30 40 50 60 MFRNSLKMLL TGGKSSRKNR SSDGGSEEPP DRRQSSVDSR QSRSGQGGIS TESDCAFEPD 70 80 90 100 110 120 YAVPPLPVSE GDAEQELGPP PSVDEAANTL MTRLGFLLGE KVTEVQPGDQ YSMEVQDENQ 130 140 150 160 170 180 TSAITQRISP CSTLTSSTAS PPASSPCSTL PPISTNATAK DCSYGAVTSP TSTLESRDSG 190 200 210 220 230 240 IIATLTSYSE NVERTKYAGE SSKELGSGGN IKPWQSQKSS MDSCLYRVDE NMTASTYSLN 250 260 270 280 290 300 KIPERNLETV LSQSVQSIPL YLMPRPNSVA ATSSAHLEDL AYLDEQRHTP LRTSLRMPRQ 310 320 330 340 350 360 SMGGARTQQD LRVRFAPYRP PDISLKPLLF EVPSITTESV FVGRDWVFHE IDAQLQSSNA 370 380 390 400 410 420 SVNQGVVIVG NIGFGKTAII SRLVALSCHG TRMRQIASDS PHASPKHVDA NRELPLTQPP 430 440 450 460 470 480 SAHSSITSGS CPGTPEMRRR QEEAMRRLAS QVVAYHYCQA DNAYTCLVPE FVHNVAALLC 490 500 510 520 530 540 RSPQLTAYRE QLLREPHLQS MLSLRSCVQD PMASFRRGVL EPLENLHKER KIPDEDFIIL 550 560 570 580 590 600 IDGLNEAEFH KPDYGDTIVS FLSKMIGKFP SWLKLIVTVR TSLQEITKLL PFHRIFLDRL 610 620 630 640 650 660 EENEAIDQDL QAYILHRIHS SSEIQNNISL NGKMDNTTFG KLSSHLKTLS QGSYLYLKLT 670 680 690 700 710 720 FDLIEKGYLV LKSSSYKVVP VSLSEVYLLQ CNMKFPTQSS FDRVMPLLNV AVASLHPLTD 730 740 750 760 770 780 EHIFQAINAG SIEGTLEWED FQQRMENLSM FLIKRRDMTR MFVHPSFREW LIWREEGEKT 790 800 810 820 830 840 KFLCDPRSGH TLLAFWFSRQ EGKLNRQQTI ELGHHILKAH IFKGLSKKVG VSSSILQGLW 850 860 870 880 890 900 ISYSTEGLSM ALASLRNLYT PNIKVSRLLI LGGANINYRT EVLNNAPILC VQSHLGYTEM 910 920 930 940 950 960 VALLLEFGAN VDASSESGLT PLGYAAAAGY LSIVVLLCKK RAKVLAAQLC CFSSLFLYFR 970 CILFLISSVT S
	Isoform 4 [UniParc]. Checksum: 38BFC3EE8DD7BD26	FASTA	1,010	112,154
	10 20 30 40 50 60 MFRNSLKMLL TGGKSSRKNR SSDGGSEEPP DRRQSSVDSR QSRSGQGGIS TESDCAFEPD 70 80 90 100 110 120 YAVPPLPVSE GDAEQELGPP PSVDEAANTL MTRLGFLLGE KVTEVQPGDQ YSMEVQDENQ 130 140 150 160 170 180 TSAITQRISP CSTLTSSTAS PPASSPCSTL PPISTNATAK DCSYGAVTSP TSTLESRDSG 190 200 210 220 230 240 IIATLTSYSE NVERTKYAGE SSKELGSGGN IKPWQSQKSS MDSCLYRVDE NMTASTYSLN 250 260 270 280 290 300 KIPERNLETV LSQSVQSIPL YLMPRPNSVA ATSSAHLEDL AYLDEQRHTP LRTSLRMPRQ 310 320 330 340 350 360 SMGGARTQQD LRVRFAPYRP PDISLKPLLF EVPSITTESV FVGRDWVFHE IDAQLQSSNA 370 380 390 400 410 420 SVNQGVVIVG NIGFGKTAII SRLVALSCHG TRMRQIASDS PHASPKHVDA NRELPLTQPP 430 440 450 460 470 480 SAHSSITSGS CPGTPEMRRR QEEAMRRLAS QVVAYHYCQA DNAYTCLVPE FVHNVAALLC 490 500 510 520 530 540 RSPQLTAYRE QLLREPHLQS MLSLRSCVQD PMASFRRGVL EPLENLHKER KIPDEDFIIL 550 560 570 580 590 600 IDGLNEAEFH KPDYGDTIVS FLSKMIGKFP SWLKLIVTVR TSLQEITKLL PFHRIFLDRL 610 620 630 640 650 660 EENEAIDQDL QAYILHRIHS SSEIQNNISL NGKMDNTTFG KLSSHLKTLS QGSYLYLKLT 670 680 690 700 710 720 FDLIEKGYLV LKSSSYKVVP VSLSEVYLLQ CNMKFPTQSS FDRVMPLLNV AVASLHPLTD 730 740 750 760 770 780 EHIFQAINAG SIEGTLEWED FQQRMENLSM FLIKRRDMTR MFVHPSFREW LIWREEGEKT 790 800 810 820 830 840 KFLCDPRSGH TLLAFWFSRQ EGKLNRQQTI ELGHHILKAH IFKGLSKKVG VSSSILQGLW 850 860 870 880 890 900 ISYSTEGLSM ALASLRNLYT PNIKVSRLLI LGGANINYRT EVLNNAPILC VQSHLGYTEM 910 920 930 940 950 960 VALLLEFGAN VDASSESGLT PLGYAAAAGY LSIVVLLCKK RAKVDHLDKN GQCALVHAAL 970 980 990 1000 1010 RGHLEVVKFL IQCDWTMAGQ QQGVFKKSHA IQQALIAAAS MGYTEVRSRQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed: 10997877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-1990 (ISOFORM 1). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 676-1990 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 843-1990 (ISOFORM 4). Tissue: Embryo.
[4]	Dahllund L., Sjodin J., Wikstrom L. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 869-1990 (ISOFORM 2).
[5]	"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed: 10574461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1448-1990 (ISOFORMS 1/2). Tissue: Brain.
[6]	"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry." Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C. Anal. Chem. 76:2763-2772(2004) [PubMed: 15144186] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1442 AND SER-1446, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[7]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169 AND SER-1827, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1457, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-171, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1530 AND SER-1534, MASS SPECTROMETRY. Tissue: Leukemic T-cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC005828 Genomic DNA. No translation available. AC005972 Genomic DNA. No translation available. AC006270 Genomic DNA. No translation available. AC015923 Genomic DNA. No translation available. AB046856 mRNA. Translation: BAB13462.2. AK001077 mRNA. No translation available. AK021886 mRNA. No translation available. AJ278120 mRNA. Translation: CAB92314.1. Sequence problems. AB032974 mRNA. Translation: BAA86462.2.
IPI	IPI00868787. IPI00892805. IPI00893434. IPI00894531.
RefSeq	NP_079461.2. NM_025185.3.
UniGene	Hs.410889.
3D structure databases
HSSP	HSSP built from PDB template 1D9S based on UniProtKB P55271.
ProteinModelPortal	Q9HCD6.
SMR	Q9HCD6. Positions 339-385, 859-1371.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9HCD6.
PTM databases
PhosphoSite	Q9HCD6.
Polymorphism databases
DMDM	189029946.
Proteomic databases
PeptideAtlas	Q9HCD6.
PRIDE	Q9HCD6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000424789; ENSP00000387593; ENSG00000170921.
GeneID	26115.
KEGG	hsa:26115.
UCSC	uc002jal.2. human.
Organism-specific databases
CTD	26115.
GeneCards	GC17P061086.
H-InvDB	HIX0014063.
HGNC	HGNC:30212. TANC2.
HPA	HPA023274.
neXtProt	NX_Q9HCD6.
PharmGKB	PA142670837.
HUGE	Search... Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09324.
GeneTree	ENSGT00600000084024.
HOVERGEN	HBG061464.
InParanoid	Q9HCD6.
OMA	TQQDLRV.
Gene expression databases
ArrayExpress	Q9HCD6.
Bgee	Q9HCD6.
CleanEx	HS_TANC2.
Genevestigator	Q9HCD6.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR013026. TPR-contain. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit. G3DSA:1.25.40.10. TPR-like_helical. 1 hit.
Pfam	PF00023. Ank. 2 hits. PF12796. Ank_2. 2 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 11 hits. SM00028. TPR. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 6 hits. PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	48114.

Entry information

Entry name

TANC2_HUMAN

Accession

Primary (citable) accession number: Q9HCD6
Secondary accession number(s): Q9HAC3 , Q9NW88, Q9NXY9, Q9ULS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	January 25, 2012
This is version 74 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.