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Protein

Nuclear receptor coactivator 5

Gene

NCOA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).1 Publication

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124160-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 5
Short name:
NCoA-5
Alternative name(s):
Coactivator independent of AF-2
Short name:
CIA
Gene namesi
Name:NCOA5
Synonyms:KIAA1637
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15909. NCOA5.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • extracellular space Source: UniProtKB
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi342I → A: Abolishes E2-inducible strong interaction with ESR1, but not basal interaction. 1 Publication1
Mutagenesisi348 – 349LL → AA: Abolishes interaction with ESR1. 1 Publication2

Organism-specific databases

DisGeNETi57727.
OpenTargetsiENSG00000124160.
PharmGKBiPA31474.

Polymorphism and mutation databases

BioMutaiNCOA5.
DMDMi28380083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000944111 – 579Nuclear receptor coactivator 5Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphothreonineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei29PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei274PhosphothreonineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei379PhosphothreonineCombined sources1
Modified residuei381PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9HCD5.
MaxQBiQ9HCD5.
PaxDbiQ9HCD5.
PeptideAtlasiQ9HCD5.
PRIDEiQ9HCD5.

PTM databases

iPTMnetiQ9HCD5.
PhosphoSitePlusiQ9HCD5.

Miscellaneous databases

PMAP-CutDBQ9HCD5.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000124160.
CleanExiHS_NCOA5.
ExpressionAtlasiQ9HCD5. baseline and differential.
GenevisibleiQ9HCD5. HS.

Organism-specific databases

HPAiHPA050231.

Interactioni

Subunit structurei

Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nr1d2Q606742EBI-2863498,EBI-5326205From a different organism.

Protein-protein interaction databases

BioGridi121747. 39 interactors.
IntActiQ9HCD5. 22 interactors.
STRINGi9606.ENSP00000290231.

Structurei

Secondary structure

1579
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi200 – 207Combined sources8
Helixi208 – 210Combined sources3
Helixi211 – 221Combined sources11
Turni222 – 224Combined sources3
Beta strandi227 – 231Combined sources5
Helixi238 – 248Combined sources11
Beta strandi251 – 256Combined sources6
Helixi258 – 263Combined sources6
Beta strandi265 – 270Combined sources6
Beta strandi272 – 274Combined sources3
Beta strandi277 – 282Combined sources6
Helixi283 – 302Combined sources20
Beta strandi304 – 306Combined sources3
Helixi345 – 350Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V95NMR-A197-313[»]
2J7XX-ray2.10B338-354[»]
2J7YX-ray1.80B338-354[»]
4ZI1X-ray2.10B341-352[»]
ProteinModelPortaliQ9HCD5.
SMRiQ9HCD5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCD5.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 158Transcription repressionAdd BLAST158
Regioni458 – 579Transcription activationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi345 – 349LXXLL motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 150Arg/Asp-rich (mixed charge)Add BLAST144

Domaini

Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.

Phylogenomic databases

eggNOGiKOG0845. Eukaryota.
ENOG410XPV4. LUCA.
GeneTreeiENSGT00530000064134.
HOVERGENiHBG052585.
InParanoidiQ9HCD5.
OMAiGSARNMG.
OrthoDBiEOG091G09XU.
PhylomeDBiQ9HCD5.
TreeFamiTF324704.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
InterProiIPR004154. Anticodon-bd.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HCD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTAPSRPSP TRRDPYGFGD SRDSRRDRSP IRGSPRREPR DGRNGRDARD
60 70 80 90 100
SRDIRDPRDL RDHRHSRDLR DHRDSRSVRD VRDVRDLRDF RDLRDSRDFR
110 120 130 140 150
DQRDPMYDRY RDMRDSRDPM YRREGSYDRY LRMDDYCRRK DDSYFDRYRD
160 170 180 190 200
SFDGRGPPGP ESQSRAKERL KREERRREEL YRQYFEEIQR RFDAERPVDC
210 220 230 240 250
SVIVVNKQTK DYAESVGRKV RDLGMVVDLI FLNTEVSLSQ ALEDVSRGGS
260 270 280 290 300
PFAIVITQQH QIHRSCTVNI MFGTPQEHRN MPQADAMVLV ARNYERYKNE
310 320 330 340 350
CREKEREEIA RQAAKMADEA ILQERERGGP EEGVRGGHPP AIQSLINLLA
360 370 380 390 400
DNRYLTAEET DKIINYLRER KERLMRSSTD SLPGPISRQP LGATSGASLK
410 420 430 440 450
TQPSSQPLQS GQVLPSATPT PSAPPTSQQE LQAKILSLFN SGTVTANSSS
460 470 480 490 500
ASPSVAAGNT PNQNFSTAAN SQPQQRSQAS GNQPPSILGQ GGSAQNMGPR
510 520 530 540 550
PGAPSQGLFG QPSSRLAPAS NMTSQRPVSS TGINFDNPSV QKALDTLIQS
560 570
GPALSHLVSQ TTAQMGQPQA PMGSYQRHY
Length:579
Mass (Da):65,536
Last modified:February 12, 2003 - v2
Checksum:iD2ADCCEBEE566A91
GO

Sequence cautioni

The sequence AAG36793 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053530326E → G.Corresponds to variant rs11549557dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230533 mRNA. Translation: AAG36793.1. Different initiation.
AF470686 mRNA. Translation: AAO33457.1.
AL035662, AL162458 Genomic DNA. Translation: CAI42972.1.
AL162458, AL035662 Genomic DNA. Translation: CAH74052.1.
CH471077 Genomic DNA. Translation: EAW75765.1.
CH471077 Genomic DNA. Translation: EAW75769.1.
BC140836 mRNA. Translation: AAI40837.1.
BC151133 mRNA. Translation: AAI51134.1.
AB046857 mRNA. Translation: BAB13463.1.
CCDSiCCDS13392.1.
RefSeqiNP_066018.1. NM_020967.2.
UniGeneiHs.654991.

Genome annotation databases

EnsembliENST00000290231; ENSP00000290231; ENSG00000124160.
GeneIDi57727.
KEGGihsa:57727.
UCSCiuc002xre.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230533 mRNA. Translation: AAG36793.1. Different initiation.
AF470686 mRNA. Translation: AAO33457.1.
AL035662, AL162458 Genomic DNA. Translation: CAI42972.1.
AL162458, AL035662 Genomic DNA. Translation: CAH74052.1.
CH471077 Genomic DNA. Translation: EAW75765.1.
CH471077 Genomic DNA. Translation: EAW75769.1.
BC140836 mRNA. Translation: AAI40837.1.
BC151133 mRNA. Translation: AAI51134.1.
AB046857 mRNA. Translation: BAB13463.1.
CCDSiCCDS13392.1.
RefSeqiNP_066018.1. NM_020967.2.
UniGeneiHs.654991.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V95NMR-A197-313[»]
2J7XX-ray2.10B338-354[»]
2J7YX-ray1.80B338-354[»]
4ZI1X-ray2.10B341-352[»]
ProteinModelPortaliQ9HCD5.
SMRiQ9HCD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121747. 39 interactors.
IntActiQ9HCD5. 22 interactors.
STRINGi9606.ENSP00000290231.

PTM databases

iPTMnetiQ9HCD5.
PhosphoSitePlusiQ9HCD5.

Polymorphism and mutation databases

BioMutaiNCOA5.
DMDMi28380083.

Proteomic databases

EPDiQ9HCD5.
MaxQBiQ9HCD5.
PaxDbiQ9HCD5.
PeptideAtlasiQ9HCD5.
PRIDEiQ9HCD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290231; ENSP00000290231; ENSG00000124160.
GeneIDi57727.
KEGGihsa:57727.
UCSCiuc002xre.4. human.

Organism-specific databases

CTDi57727.
DisGeNETi57727.
GeneCardsiNCOA5.
HGNCiHGNC:15909. NCOA5.
HPAiHPA050231.
neXtProtiNX_Q9HCD5.
OpenTargetsiENSG00000124160.
PharmGKBiPA31474.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0845. Eukaryota.
ENOG410XPV4. LUCA.
GeneTreeiENSGT00530000064134.
HOVERGENiHBG052585.
InParanoidiQ9HCD5.
OMAiGSARNMG.
OrthoDBiEOG091G09XU.
PhylomeDBiQ9HCD5.
TreeFamiTF324704.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124160-MONOMER.

Miscellaneous databases

ChiTaRSiNCOA5. human.
EvolutionaryTraceiQ9HCD5.
GeneWikiiNCOA5.
GenomeRNAii57727.
PMAP-CutDBQ9HCD5.
PROiQ9HCD5.

Gene expression databases

BgeeiENSG00000124160.
CleanExiHS_NCOA5.
ExpressionAtlasiQ9HCD5. baseline and differential.
GenevisibleiQ9HCD5. HS.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
InterProiIPR004154. Anticodon-bd.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNCOA5_HUMAN
AccessioniPrimary (citable) accession number: Q9HCD5
Secondary accession number(s): B2RTV9
, E1P5R0, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: November 2, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.