Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor HES-4

Gene

HES4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-4
Short name:
hHES4
Alternative name(s):
Class B basic helix-loop-helix protein 42
Short name:
bHLHb42
Hairy and enhancer of split 4
bHLH factor Hes4
Gene namesi
Name:HES4
Synonyms:BHLHB42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24149. HES4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57801.
OpenTargetsiENSG00000188290.
PharmGKBiPA134975318.

Polymorphism and mutation databases

BioMutaiHES4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272111 – 221Transcription factor HES-4Add BLAST221

Proteomic databases

PeptideAtlasiQ9HCC6.
PRIDEiQ9HCC6.

2D gel databases

UCD-2DPAGEQ9HCC6.

PTM databases

iPTMnetiQ9HCC6.
PhosphoSitePlusiQ9HCC6.

Expressioni

Gene expression databases

BgeeiENSG00000188290.
CleanExiHS_HES4.
ExpressionAtlasiQ9HCC6. baseline and differential.
GenevisibleiQ9HCC6. HS.

Organism-specific databases

HPAiHPA062465.

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121772. 6 interactors.
IntActiQ9HCC6. 10 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9HCC6.
SMRiQ9HCC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 91bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini110 – 143OrangePROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi216 – 219WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi152 – 218Pro-richAdd BLAST67

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).By similarity
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Phylogenomic databases

GeneTreeiENSGT00700000104168.
HOGENOMiHOG000236346.
HOVERGENiHBG005960.
InParanoidiQ9HCC6.
KOiK09089.
PhylomeDBiQ9HCC6.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR003650. Orange_dom.
PfamiView protein in Pfam
PF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HCC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADTPGKPS ASPMAGAPAS ASRTPDKPRS AAEHRKSSKP VMEKRRRARI
60 70 80 90 100
NESLAQLKTL ILDALRKESS RHSKLEKADI LEMTVRHLRS LRRVQVTAAL
110 120 130 140 150
SADPAVLGKY RAGFHECLAE VNRFLAGCEG VPADVRSRLL GHLAACLRQL
160 170 180 190 200
GPSRRPASLS PAAPAEAPAP EVYAGRPLLP SLGGPFPLLA PPLLPGLTRA
210 220
LPAAPRAGPQ GPGGPWRPWL R
Length:221
Mass (Da):23,523
Last modified:March 1, 2001 - v1
Checksum:iADFAE485C36EEBC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048791 mRNA. Translation: BAB13510.1.
AL645608 Genomic DNA. Translation: CAI15572.1.
BC012351 mRNA. Translation: AAH12351.1.
CCDSiCCDS5.1.
RefSeqiNP_001135939.1. NM_001142467.1.
NP_066993.1. NM_021170.3.
UniGeneiHs.154029.

Genome annotation databases

EnsembliENST00000304952; ENSP00000304595; ENSG00000188290.
GeneIDi57801.
KEGGihsa:57801.
UCSCiuc001aci.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048791 mRNA. Translation: BAB13510.1.
AL645608 Genomic DNA. Translation: CAI15572.1.
BC012351 mRNA. Translation: AAH12351.1.
CCDSiCCDS5.1.
RefSeqiNP_001135939.1. NM_001142467.1.
NP_066993.1. NM_021170.3.
UniGeneiHs.154029.

3D structure databases

ProteinModelPortaliQ9HCC6.
SMRiQ9HCC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121772. 6 interactors.
IntActiQ9HCC6. 10 interactors.

PTM databases

iPTMnetiQ9HCC6.
PhosphoSitePlusiQ9HCC6.

Polymorphism and mutation databases

BioMutaiHES4.

2D gel databases

UCD-2DPAGEQ9HCC6.

Proteomic databases

PeptideAtlasiQ9HCC6.
PRIDEiQ9HCC6.

Protocols and materials databases

DNASUi57801.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304952; ENSP00000304595; ENSG00000188290.
GeneIDi57801.
KEGGihsa:57801.
UCSCiuc001aci.3. human.

Organism-specific databases

CTDi57801.
DisGeNETi57801.
GeneCardsiHES4.
HGNCiHGNC:24149. HES4.
HPAiHPA062465.
MIMi608060. gene.
neXtProtiNX_Q9HCC6.
OpenTargetsiENSG00000188290.
PharmGKBiPA134975318.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00700000104168.
HOGENOMiHOG000236346.
HOVERGENiHBG005960.
InParanoidiQ9HCC6.
KOiK09089.
PhylomeDBiQ9HCC6.

Miscellaneous databases

GenomeRNAii57801.
PROiQ9HCC6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188290.
CleanExiHS_HES4.
ExpressionAtlasiQ9HCC6. baseline and differential.
GenevisibleiQ9HCC6. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR003650. Orange_dom.
PfamiView protein in Pfam
PF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHES4_HUMAN
AccessioniPrimary (citable) accession number: Q9HCC6
Secondary accession number(s): Q5SVA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2001
Last modified: February 15, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.