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Protein

Transcription factor HES-4

Gene

HES4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3' (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-4
Short name:
hHES4
Alternative name(s):
Class B basic helix-loop-helix protein 42
Short name:
bHLHb42
Hairy and enhancer of split 4
bHLH factor Hes4
Gene namesi
Name:HES4
Synonyms:BHLHB42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24149. HES4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134975318.

Polymorphism and mutation databases

BioMutaiHES4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Transcription factor HES-4PRO_0000127211Add
BLAST

Proteomic databases

PeptideAtlasiQ9HCC6.
PRIDEiQ9HCC6.

2D gel databases

UCD-2DPAGEQ9HCC6.

PTM databases

iPTMnetiQ9HCC6.
PhosphoSiteiQ9HCC6.

Expressioni

Gene expression databases

BgeeiQ9HCC6.
CleanExiHS_HES4.
ExpressionAtlasiQ9HCC6. baseline and differential.
GenevisibleiQ9HCC6. HS.

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121772. 6 interactions.
IntActiQ9HCC6. 10 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9HCC6.
SMRiQ9HCC6. Positions 27-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 9158bHLHPROSITE-ProRule annotationAdd
BLAST
Domaini110 – 14334OrangePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi216 – 2194WRPW motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi152 – 21867Pro-richAdd
BLAST

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).By similarity
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 1 Orange domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00700000104168.
HOGENOMiHOG000236346.
HOVERGENiHBG005960.
InParanoidiQ9HCC6.
KOiK09089.
PhylomeDBiQ9HCC6.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003650. Orange_dom.
[Graphical view]
PfamiPF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HCC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADTPGKPS ASPMAGAPAS ASRTPDKPRS AAEHRKSSKP VMEKRRRARI
60 70 80 90 100
NESLAQLKTL ILDALRKESS RHSKLEKADI LEMTVRHLRS LRRVQVTAAL
110 120 130 140 150
SADPAVLGKY RAGFHECLAE VNRFLAGCEG VPADVRSRLL GHLAACLRQL
160 170 180 190 200
GPSRRPASLS PAAPAEAPAP EVYAGRPLLP SLGGPFPLLA PPLLPGLTRA
210 220
LPAAPRAGPQ GPGGPWRPWL R
Length:221
Mass (Da):23,523
Last modified:March 1, 2001 - v1
Checksum:iADFAE485C36EEBC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048791 mRNA. Translation: BAB13510.1.
AL645608 Genomic DNA. Translation: CAI15572.1.
BC012351 mRNA. Translation: AAH12351.1.
CCDSiCCDS5.1.
RefSeqiNP_001135939.1. NM_001142467.1.
NP_066993.1. NM_021170.3.
UniGeneiHs.154029.

Genome annotation databases

EnsembliENST00000304952; ENSP00000304595; ENSG00000188290.
GeneIDi57801.
KEGGihsa:57801.
UCSCiuc001aci.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048791 mRNA. Translation: BAB13510.1.
AL645608 Genomic DNA. Translation: CAI15572.1.
BC012351 mRNA. Translation: AAH12351.1.
CCDSiCCDS5.1.
RefSeqiNP_001135939.1. NM_001142467.1.
NP_066993.1. NM_021170.3.
UniGeneiHs.154029.

3D structure databases

ProteinModelPortaliQ9HCC6.
SMRiQ9HCC6. Positions 27-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121772. 6 interactions.
IntActiQ9HCC6. 10 interactions.

PTM databases

iPTMnetiQ9HCC6.
PhosphoSiteiQ9HCC6.

Polymorphism and mutation databases

BioMutaiHES4.

2D gel databases

UCD-2DPAGEQ9HCC6.

Proteomic databases

PeptideAtlasiQ9HCC6.
PRIDEiQ9HCC6.

Protocols and materials databases

DNASUi57801.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304952; ENSP00000304595; ENSG00000188290.
GeneIDi57801.
KEGGihsa:57801.
UCSCiuc001aci.3. human.

Organism-specific databases

CTDi57801.
GeneCardsiHES4.
HGNCiHGNC:24149. HES4.
MIMi608060. gene.
neXtProtiNX_Q9HCC6.
PharmGKBiPA134975318.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00700000104168.
HOGENOMiHOG000236346.
HOVERGENiHBG005960.
InParanoidiQ9HCC6.
KOiK09089.
PhylomeDBiQ9HCC6.

Miscellaneous databases

GenomeRNAii57801.
PROiQ9HCC6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HCC6.
CleanExiHS_HES4.
ExpressionAtlasiQ9HCC6. baseline and differential.
GenevisibleiQ9HCC6. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003650. Orange_dom.
[Graphical view]
PfamiPF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm."
    Bessho Y., Miyoshi G., Sakata R., Kageyama R.
    Genes Cells 6:175-185(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiHES4_HUMAN
AccessioniPrimary (citable) accession number: Q9HCC6
Secondary accession number(s): Q5SVA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.