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Q9HC96 (CAN10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calpain-10

EC=3.4.22.-
Alternative name(s):
Calcium-activated neutral proteinase 10
Short name=CANP 10
Gene names
Name:CAPN10
Synonyms:KIAA1845
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length672 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake. Ref.9

Catalytic activity

Broad endopeptidase specificity.

Tissue specificity

Detected in primary skeletal muscle cells (at protein level). Ubiquitous. Ref.9

Involvement in disease

Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1) [MIM:601283]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.1 Ref.8

Sequence similarities

Belongs to the peptidase C2 family.

Contains 1 calpain catalytic domain.

Sequence caution

The sequence BAB47474.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseDiabetes mellitus
   DomainRepeat
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin cytoskeleton reorganization

Inferred from sequence or structural similarity PubMed 12974673. Source: BHF-UCL

cellular component disassembly involved in execution phase of apoptosis

Inferred by curator. Source: BHF-UCL

cellular response to insulin stimulus

Inferred from mutant phenotype Ref.9. Source: BHF-UCL

positive regulation of glucose import

Inferred from mutant phenotype Ref.9. Source: BHF-UCL

positive regulation of insulin secretion

Inferred from mutant phenotype PubMed 15471947. Source: BHF-UCL

positive regulation of intracellular transport

Inferred from sequence or structural similarity PubMed 12974673. Source: BHF-UCL

positive regulation of type B pancreatic cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

proteolysis

Inferred from mutant phenotype PubMed 15044459. Source: BHF-UCL

type B pancreatic cell apoptotic process

Inferred from direct assay PubMed 15044459. Source: BHF-UCL

   Cellular_componentcell

Inferred from direct assay Ref.9. Source: BHF-UCL

cytosol

Inferred from direct assay PubMed 16790502. Source: BHF-UCL

mitochondrion

Inferred from direct assay PubMed 16790502. Source: BHF-UCL

plasma membrane

Inferred from sequence or structural similarity. Source: BHF-UCL

   Molecular_functionSNARE binding

Inferred from sequence or structural similarity. Source: BHF-UCL

calcium-dependent cysteine-type endopeptidase activity

Inferred from mutant phenotype PubMed 15044459. Source: BHF-UCL

cytoskeletal protein binding

Inferred from sequence or structural similarity. Source: BHF-UCL

Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q9HC96-1)

Also known as: CAPN10a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q9HC96-2)

Also known as: CAPN10b;

The sequence of this isoform differs from the canonical sequence as follows:
     494-544: SAIRAVAKNT...FASYPTNPCF → RALAPAASAS...HPHCCCRSRC
     545-672: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform C (identifier: Q9HC96-3)

Also known as: CAPN10c;

The sequence of this isoform differs from the canonical sequence as follows:
     428-582: Missing.
Isoform D (identifier: Q9HC96-4)

Also known as: CAPN10d;

The sequence of this isoform differs from the canonical sequence as follows:
     494-513: SAIRAVAKNTTPGAALPAGE → RSQRVEGARTHPHCCCRSRC
     514-672: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform E (identifier: Q9HC96-5)

Also known as: CAPN10e;

The sequence of this isoform differs from the canonical sequence as follows:
     427-444: VEKRRVNLPRVLSMPPVA → GVTLGTTLFPVPSWMWPT
     445-672: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform F (identifier: Q9HC96-6)

Also known as: CAPN10f;

The sequence of this isoform differs from the canonical sequence as follows:
     154-274: VYAKVHGSYE...WGRRCWQGLW → GPWVLRAPVG...VLAGALERGG
     275-672: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform G (identifier: Q9HC96-7)

Also known as: CAPN10g;

The sequence of this isoform differs from the canonical sequence as follows:
     93-139: IPPGQPSWAD...CLAGRLCFSR → SCPVQLPADW...PDSATWGSWK
     140-672: Missing.
Isoform H (identifier: Q9HC96-8)

Also known as: CAPN10h;

The sequence of this isoform differs from the canonical sequence as follows:
     48-581: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 672672Calpain-10
PRO_0000207725

Regions

Domain13 – 321309Calpain catalytic
Region322 – 494173Domain III 1
Region513 – 654142Domain III 2

Sites

Active site731 By similarity
Active site2381 By similarity
Active site2631 By similarity

Natural variations

Alternative sequence48 – 581534Missing in isoform H.
VSP_005243
Alternative sequence93 – 13947IPPGQ…LCFSR → SCPVQLPADWTCKVQPVWLE FPCLPISCRLRVSSDTSPDS ATWGSWK in isoform G.
VSP_005241
Alternative sequence140 – 672533Missing in isoform G.
VSP_005242
Alternative sequence154 – 274121VYAKV…WQGLW → GPWVLRAPVGRAGGGCPGGP DRRPGRKMEPEGRSRKRRPA GQARPLGAQDLSAAAPPEGP VSDQLLRAQPQSRCPGAGGV PCLHCLGPAGAPGSGGPVHP AAADPEPLGPAVLAGALERG G in isoform F.
VSP_005239
Alternative sequence275 – 672398Missing in isoform F.
VSP_005240
Alternative sequence427 – 44418VEKRR…MPPVA → GVTLGTTLFPVPSWMWPT in isoform E.
VSP_005237
Alternative sequence428 – 582155Missing in isoform C.
VSP_005234
Alternative sequence445 – 672228Missing in isoform E.
VSP_005238
Alternative sequence494 – 54451SAIRA…TNPCF → RALAPAASASLCISTAGPVT PSSTPSASISSRSQRVEGAR THPHCCCRSRC in isoform B.
VSP_005232
Alternative sequence494 – 51320SAIRA…LPAGE → RSQRVEGARTHPHCCCRSRC in isoform D.
VSP_005235
Alternative sequence514 – 672159Missing in isoform D.
VSP_005236
Alternative sequence545 – 672128Missing in isoform B.
VSP_005233
Natural variant2001P → T. Ref.1
Corresponds to variant rs3792268 [ dbSNP | Ensembl ].
VAR_014437
Natural variant2021R → H. Ref.1
VAR_014438
Natural variant2761E → G in a colorectal cancer sample; somatic mutation. Ref.10
VAR_036049
Natural variant3411A → V. Ref.1
VAR_014439
Natural variant5041T → A. Ref.1 Ref.4
Corresponds to variant rs7607759 [ dbSNP | Ensembl ].
VAR_014440
Natural variant5291A → S. Ref.1
VAR_014441
Natural variant6131S → N. Ref.1
Corresponds to variant rs146148004 [ dbSNP | Ensembl ].
VAR_014442
Natural variant6661I → V. Ref.1 Ref.3 Ref.4 Ref.6
Corresponds to variant rs2975766 [ dbSNP | Ensembl ].
VAR_014443

Experimental info

Sequence conflict1951G → S in BAC11220. Ref.4
Sequence conflict3731E → K in AAG17969. Ref.1
Sequence conflict3731E → K in AAG17971. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform A (CAPN10a) [UniParc].

Last modified January 11, 2011. Version 2.
Checksum: 74A48D879E896C71

FASTA67274,952
        10         20         30         40         50         60 
MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC ATPRLFPDDP 

        70         80         90        100        110        120 
REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW ADQEYRGSFT CRIWQFGRWV 

       130        140        150        160        170        180 
EVTTDDRLPC LAGRLCFSRC QREDVFWLPL LEKVYAKVHG SYEHLWAGQV ADALVDLTGG 

       190        200        210        220        230        240 
LAERWNLKGV AGSGGQQDRP GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG ARELGEFHAF 

       250        260        270        280        290        300 
IVSDLRELQG QAGQCILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVAS ELLSQLQEGE 

       310        320        330        340        350        360 
FWVEEEEFLR EFDELTVGYP VTEAGHLQSL YTERLLCHTR ALPGAWVKGQ SAGGCRNNSG 

       370        380        390        400        410        420 
FPSNPKFWLR VSEPSEVYIA VLQRSRLHAA DWAGRARALV GDSHTSWSPA SIPGKHYQAV 

       430        440        450        460        470        480 
GLHLWKVEKR RVNLPRVLSM PPVAGTACHA YDREVHLRCE LSPGYYLAVP STFLKDAPGE 

       490        500        510        520        530        540 
FLLRVFSTGR VSLSAIRAVA KNTTPGAALP AGEWGTVQLR GSWRVGQTAG GSRNFASYPT 

       550        560        570        580        590        600 
NPCFPFSVPE GPGPRCVRIT LHQHCRPSDT EFHPIGFHIF QVPEGGRSQD APPLLLQEPL 

       610        620        630        640        650        660 
LSCVPHRYAQ EVSRLCLLPA GTYKVVPSTY LPDTEGAFTV TIATRIDRPS IHSQEMLGQF 

       670 
LQEVSIMAVM KT 

« Hide

Isoform B (CAPN10b) [UniParc].

Checksum: 17CE7B881A20855E
Show »

FASTA54460,657
Isoform C (CAPN10c) [UniParc].

Checksum: 8D81A0FA44993180
Show »

FASTA51757,999
Isoform D (CAPN10d) [UniParc].

Checksum: C66DC853F87AEC9C
Show »

FASTA51357,816
Isoform E (CAPN10e) [UniParc].

Checksum: 32E4706B7D06D58E
Show »

FASTA44449,994
Isoform F (CAPN10f) [UniParc].

Checksum: 570C2A6CB9B6B903
Show »

FASTA27429,453
Isoform G (CAPN10g) [UniParc].

Checksum: C934A0FD16963EC6
Show »

FASTA13915,583
Isoform H (CAPN10h) [UniParc].

Checksum: 28589100F645B66B
Show »

FASTA13815,275

References

« Hide 'large scale' references
[1]"Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus."
Horikawa Y., Oda N., Cox N.J., Li X., Orho-Melander M., Hara M., Hinokio Y., Lindner T.H., Mashima H., Schwarz P.E.H., del Bosque-Plata L., Horikawa Y., Oda Y., Yoshiuchi I., Colilla S., Polonsky K.S., Wei S., Concannon P. expand/collapse author list , Iwasaki N., Schulze J., Baier L.J., Bogardus C., Groop L., Boerwinkle E., Hanis C.L., Bell G.I.
Nat. Genet. 26:163-175(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, VARIANTS THR-200; HIS-202; VAL-341; ALA-504; SER-529; ASN-613 AND VAL-666, INVOLVEMENT IN SUSCEPTIBILITY TO NIDDM1.
[2]Erratum
Horikawa Y., Oda N., Cox N.J., Li X., Orho-Melander M., Hara M., Hinokio Y., Lindner T.H., Mashima H., Schwarz P.E.H., del Bosque-Plata L., Horikawa Y., Oda Y., Yoshiuchi I., Colilla S., Polonsky K.S., Wei S., Concannon P. expand/collapse author list , Iwasaki N., Schulze J., Baier L.J., Bogardus C., Groop L., Boerwinkle E., Hanis C.L., Bell G.I.
Nat. Genet. 26:502-502(2000)
[3]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A), VARIANT VAL-666.
Tissue: Brain.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A), VARIANTS ALA-504 AND VAL-666.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A), VARIANT VAL-666.
Tissue: Skin and Uterus.
[7]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[8]"A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes."
Kang E.S., Kim H.J., Nam M., Nam C.M., Ahn C.W., Cha B.S., Lee H.C.
J. Hum. Genet. 51:629-633(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO NIDDM1.
[9]"Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells."
Brown A.E., Yeaman S.J., Walker M.
Mol. Genet. Metab. 91:318-324(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[10]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-276.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF089088 mRNA. Translation: AAG17966.1.
AF089090 mRNA. Translation: AAG17968.1.
AF089091 mRNA. Translation: AAG17969.1.
AF089092 mRNA. Translation: AAG17970.1.
AF089093 mRNA. Translation: AAG17971.1.
AF089094 mRNA. Translation: AAG17972.1.
AF089095 mRNA. Translation: AAG17973.1.
AF089096 mRNA. Translation: AAG17974.1.
AB058748 mRNA. Translation: BAB47474.1. Different initiation.
AK074807 mRNA. Translation: BAC11220.1.
AC124862 Genomic DNA. Translation: AAX88944.1.
BC004260 mRNA. Translation: AAH04260.1.
BC007553 mRNA. Translation: AAH07553.2.
RefSeqNP_075571.1. NM_023083.3.
NP_075573.2. NM_023085.3.
UniGeneHs.728234.

3D structure databases

ProteinModelPortalQ9HC96.
SMRQ9HC96. Positions 10-487, 502-638.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116305. 4 interactions.
IntActQ9HC96. 4 interactions.
MINTMINT-104261.

Protein family/group databases

MEROPSC02.018.

PTM databases

PhosphoSiteQ9HC96.

Polymorphism databases

DMDM317373329.

Proteomic databases

PaxDbQ9HC96.
PRIDEQ9HC96.

Protocols and materials databases

DNASU11132.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000270361; ENSP00000270361; ENSG00000142330. [Q9HC96-6]
ENST00000270364; ENSP00000270364; ENSG00000142330. [Q9HC96-7]
ENST00000352879; ENSP00000289381; ENSG00000142330. [Q9HC96-8]
ENST00000354082; ENSP00000270362; ENSG00000142330. [Q9HC96-3]
ENST00000357048; ENSP00000349556; ENSG00000142330. [Q9HC96-4]
ENST00000391982; ENSP00000375842; ENSG00000142330. [Q9HC96-5]
ENST00000391983; ENSP00000375843; ENSG00000142330. [Q9HC96-2]
ENST00000391984; ENSP00000375844; ENSG00000142330. [Q9HC96-1]
ENST00000416591; ENSP00000400144; ENSG00000142330. [Q9HC96-5]
GeneID11132.
KEGGhsa:11132.
UCSCuc002vzk.2. human. [Q9HC96-1]
uc002vzl.2. human. [Q9HC96-3]
uc002vzm.2. human. [Q9HC96-8]
uc002vzq.2. human. [Q9HC96-7]

Organism-specific databases

CTD11132.
GeneCardsGC02P241545.
HGNCHGNC:1477. CAPN10.
HPAHPA004170.
MIM601283. phenotype.
605286. gene.
neXtProtNX_Q9HC96.
PharmGKBPA26058.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG313372.
HOVERGENHBG050787.
InParanoidQ9HC96.
KOK08579.
OMAVHLRCEL.
OrthoDBEOG7RV9FM.
PhylomeDBQ9HC96.
TreeFamTF314748.

Gene expression databases

ArrayExpressQ9HC96.
BgeeQ9HC96.
GenevestigatorQ9HC96.

Family and domain databases

InterProIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR028791. CAPN10.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERPTHR10183:SF30. PTHR10183:SF30. 1 hit.
PfamPF01067. Calpain_III. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSPR00704. CALPAIN.
SMARTSM00720. calpain_III. 2 hits.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMSSF49758. SSF49758. 2 hits.
PROSITEPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCAPN10. human.
GeneWikiCAPN10.
GenomeRNAi11132.
NextBio42312.
PROQ9HC96.
SOURCESearch...

Entry information

Entry nameCAN10_HUMAN
AccessionPrimary (citable) accession number: Q9HC96
Secondary accession number(s): A8MVS7 expand/collapse secondary AC list , Q4ZFV1, Q8NCD4, Q96IG4, Q96JI2, Q9HC89, Q9HC90, Q9HC91, Q9HC92, Q9HC93, Q9HC94, Q9HC95
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM