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Q9HC96

- CAN10_HUMAN

UniProt

Q9HC96 - CAN10_HUMAN

Protein

Calpain-10

Gene

CAPN10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.1 Publication

    Catalytic activityi

    Broad endopeptidase specificity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731By similarity
    Active sitei238 – 2381By similarity
    Active sitei263 – 2631By similarity

    GO - Molecular functioni

    1. calcium-dependent cysteine-type endopeptidase activity Source: BHF-UCL
    2. cytoskeletal protein binding Source: BHF-UCL
    3. SNARE binding Source: BHF-UCL

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: BHF-UCL
    2. cellular component disassembly involved in execution phase of apoptosis Source: BHF-UCL
    3. cellular response to insulin stimulus Source: BHF-UCL
    4. positive regulation of glucose import Source: BHF-UCL
    5. positive regulation of insulin secretion Source: BHF-UCL
    6. positive regulation of intracellular transport Source: BHF-UCL
    7. positive regulation of type B pancreatic cell apoptotic process Source: Ensembl
    8. proteolysis Source: BHF-UCL
    9. type B pancreatic cell apoptotic process Source: BHF-UCL

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Protein family/group databases

    MEROPSiC02.018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calpain-10 (EC:3.4.22.-)
    Alternative name(s):
    Calcium-activated neutral proteinase 10
    Short name:
    CANP 10
    Gene namesi
    Name:CAPN10
    Synonyms:KIAA1845
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:1477. CAPN10.

    Subcellular locationi

    GO - Cellular componenti

    1. cell Source: BHF-UCL
    2. cytosol Source: BHF-UCL
    3. mitochondrion Source: BHF-UCL
    4. plasma membrane Source: BHF-UCL

    Pathology & Biotechi

    Involvement in diseasei

    Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1) [MIM:601283]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.2 Publications
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Keywords - Diseasei

    Diabetes mellitus

    Organism-specific databases

    MIMi601283. phenotype.
    PharmGKBiPA26058.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 672672Calpain-10PRO_0000207725Add
    BLAST

    Proteomic databases

    PaxDbiQ9HC96.
    PRIDEiQ9HC96.

    PTM databases

    PhosphoSiteiQ9HC96.

    Expressioni

    Tissue specificityi

    Detected in primary skeletal muscle cells (at protein level). Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ9HC96.
    BgeeiQ9HC96.
    GenevestigatoriQ9HC96.

    Organism-specific databases

    HPAiHPA004170.

    Interactioni

    Protein-protein interaction databases

    BioGridi116305. 4 interactions.
    IntActiQ9HC96. 4 interactions.
    MINTiMINT-104261.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HC96.
    SMRiQ9HC96. Positions 10-487, 502-638.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 321309Calpain catalyticPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni322 – 494173Domain III 1Add
    BLAST
    Regioni513 – 654142Domain III 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C2 family.Curated
    Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG313372.
    HOVERGENiHBG050787.
    InParanoidiQ9HC96.
    KOiK08579.
    OMAiVHLRCEL.
    OrthoDBiEOG7RV9FM.
    PhylomeDBiQ9HC96.
    TreeFamiTF314748.

    Family and domain databases

    InterProiIPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR028791. CAPN10.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view]
    PANTHERiPTHR10183:SF30. PTHR10183:SF30. 1 hit.
    PfamiPF01067. Calpain_III. 2 hits.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view]
    PRINTSiPR00704. CALPAIN.
    SMARTiSM00720. calpain_III. 2 hits.
    SM00230. CysPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49758. SSF49758. 2 hits.
    PROSITEiPS50203. CALPAIN_CAT. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q9HC96-1) [UniParc]FASTAAdd to Basket

    Also known as: CAPN10a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC    50
    ATPRLFPDDP REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW 100
    ADQEYRGSFT CRIWQFGRWV EVTTDDRLPC LAGRLCFSRC QREDVFWLPL 150
    LEKVYAKVHG SYEHLWAGQV ADALVDLTGG LAERWNLKGV AGSGGQQDRP 200
    GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG ARELGEFHAF IVSDLRELQG 250
    QAGQCILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVAS ELLSQLQEGE 300
    FWVEEEEFLR EFDELTVGYP VTEAGHLQSL YTERLLCHTR ALPGAWVKGQ 350
    SAGGCRNNSG FPSNPKFWLR VSEPSEVYIA VLQRSRLHAA DWAGRARALV 400
    GDSHTSWSPA SIPGKHYQAV GLHLWKVEKR RVNLPRVLSM PPVAGTACHA 450
    YDREVHLRCE LSPGYYLAVP STFLKDAPGE FLLRVFSTGR VSLSAIRAVA 500
    KNTTPGAALP AGEWGTVQLR GSWRVGQTAG GSRNFASYPT NPCFPFSVPE 550
    GPGPRCVRIT LHQHCRPSDT EFHPIGFHIF QVPEGGRSQD APPLLLQEPL 600
    LSCVPHRYAQ EVSRLCLLPA GTYKVVPSTY LPDTEGAFTV TIATRIDRPS 650
    IHSQEMLGQF LQEVSIMAVM KT 672
    Length:672
    Mass (Da):74,952
    Last modified:January 11, 2011 - v2
    Checksum:i74A48D879E896C71
    GO
    Isoform B (identifier: Q9HC96-2) [UniParc]FASTAAdd to Basket

    Also known as: CAPN10b

    The sequence of this isoform differs from the canonical sequence as follows:
         494-544: SAIRAVAKNT...FASYPTNPCF → RALAPAASAS...HPHCCCRSRC
         545-672: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:544
    Mass (Da):60,657
    Checksum:i17CE7B881A20855E
    GO
    Isoform C (identifier: Q9HC96-3) [UniParc]FASTAAdd to Basket

    Also known as: CAPN10c

    The sequence of this isoform differs from the canonical sequence as follows:
         428-582: Missing.

    Show »
    Length:517
    Mass (Da):57,999
    Checksum:i8D81A0FA44993180
    GO
    Isoform D (identifier: Q9HC96-4) [UniParc]FASTAAdd to Basket

    Also known as: CAPN10d

    The sequence of this isoform differs from the canonical sequence as follows:
         494-513: SAIRAVAKNTTPGAALPAGE → RSQRVEGARTHPHCCCRSRC
         514-672: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:513
    Mass (Da):57,816
    Checksum:iC66DC853F87AEC9C
    GO
    Isoform E (identifier: Q9HC96-5) [UniParc]FASTAAdd to Basket

    Also known as: CAPN10e

    The sequence of this isoform differs from the canonical sequence as follows:
         427-444: VEKRRVNLPRVLSMPPVA → GVTLGTTLFPVPSWMWPT
         445-672: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:444
    Mass (Da):49,994
    Checksum:i32E4706B7D06D58E
    GO
    Isoform F (identifier: Q9HC96-6) [UniParc]FASTAAdd to Basket

    Also known as: CAPN10f

    The sequence of this isoform differs from the canonical sequence as follows:
         154-274: VYAKVHGSYE...WGRRCWQGLW → GPWVLRAPVG...VLAGALERGG
         275-672: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:274
    Mass (Da):29,453
    Checksum:i570C2A6CB9B6B903
    GO
    Isoform G (identifier: Q9HC96-7) [UniParc]FASTAAdd to Basket

    Also known as: CAPN10g

    The sequence of this isoform differs from the canonical sequence as follows:
         93-139: IPPGQPSWAD...CLAGRLCFSR → SCPVQLPADW...PDSATWGSWK
         140-672: Missing.

    Show »
    Length:139
    Mass (Da):15,583
    Checksum:iC934A0FD16963EC6
    GO
    Isoform H (identifier: Q9HC96-8) [UniParc]FASTAAdd to Basket

    Also known as: CAPN10h

    The sequence of this isoform differs from the canonical sequence as follows:
         48-581: Missing.

    Show »
    Length:138
    Mass (Da):15,275
    Checksum:i28589100F645B66B
    GO

    Sequence cautioni

    The sequence BAB47474.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti195 – 1951G → S in BAC11220. (PubMed:14702039)Curated
    Sequence conflicti373 – 3731E → K in AAG17969. (PubMed:11017071)Curated
    Sequence conflicti373 – 3731E → K in AAG17971. (PubMed:11017071)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti200 – 2001P → T.1 Publication
    Corresponds to variant rs3792268 [ dbSNP | Ensembl ].
    VAR_014437
    Natural varianti202 – 2021R → H.1 Publication
    VAR_014438
    Natural varianti276 – 2761E → G in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036049
    Natural varianti341 – 3411A → V.1 Publication
    VAR_014439
    Natural varianti504 – 5041T → A.2 Publications
    Corresponds to variant rs7607759 [ dbSNP | Ensembl ].
    VAR_014440
    Natural varianti529 – 5291A → S.1 Publication
    VAR_014441
    Natural varianti613 – 6131S → N.1 Publication
    Corresponds to variant rs146148004 [ dbSNP | Ensembl ].
    VAR_014442
    Natural varianti666 – 6661I → V.4 Publications
    Corresponds to variant rs2975766 [ dbSNP | Ensembl ].
    VAR_014443

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei48 – 581534Missing in isoform H. CuratedVSP_005243Add
    BLAST
    Alternative sequencei93 – 13947IPPGQ…LCFSR → SCPVQLPADWTCKVQPVWLE FPCLPISCRLRVSSDTSPDS ATWGSWK in isoform G. CuratedVSP_005241Add
    BLAST
    Alternative sequencei140 – 672533Missing in isoform G. CuratedVSP_005242Add
    BLAST
    Alternative sequencei154 – 274121VYAKV…WQGLW → GPWVLRAPVGRAGGGCPGGP DRRPGRKMEPEGRSRKRRPA GQARPLGAQDLSAAAPPEGP VSDQLLRAQPQSRCPGAGGV PCLHCLGPAGAPGSGGPVHP AAADPEPLGPAVLAGALERG G in isoform F. CuratedVSP_005239Add
    BLAST
    Alternative sequencei275 – 672398Missing in isoform F. CuratedVSP_005240Add
    BLAST
    Alternative sequencei427 – 44418VEKRR…MPPVA → GVTLGTTLFPVPSWMWPT in isoform E. CuratedVSP_005237Add
    BLAST
    Alternative sequencei428 – 582155Missing in isoform C. CuratedVSP_005234Add
    BLAST
    Alternative sequencei445 – 672228Missing in isoform E. CuratedVSP_005238Add
    BLAST
    Alternative sequencei494 – 54451SAIRA…TNPCF → RALAPAASASLCISTAGPVT PSSTPSASISSRSQRVEGAR THPHCCCRSRC in isoform B. CuratedVSP_005232Add
    BLAST
    Alternative sequencei494 – 51320SAIRA…LPAGE → RSQRVEGARTHPHCCCRSRC in isoform D. CuratedVSP_005235Add
    BLAST
    Alternative sequencei514 – 672159Missing in isoform D. CuratedVSP_005236Add
    BLAST
    Alternative sequencei545 – 672128Missing in isoform B. CuratedVSP_005233Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089088 mRNA. Translation: AAG17966.1.
    AF089090 mRNA. Translation: AAG17968.1.
    AF089091 mRNA. Translation: AAG17969.1.
    AF089092 mRNA. Translation: AAG17970.1.
    AF089093 mRNA. Translation: AAG17971.1.
    AF089094 mRNA. Translation: AAG17972.1.
    AF089095 mRNA. Translation: AAG17973.1.
    AF089096 mRNA. Translation: AAG17974.1.
    AB058748 mRNA. Translation: BAB47474.1. Different initiation.
    AK074807 mRNA. Translation: BAC11220.1.
    AC124862 Genomic DNA. Translation: AAX88944.1.
    BC004260 mRNA. Translation: AAH04260.1.
    BC007553 mRNA. Translation: AAH07553.2.
    CCDSiCCDS33420.1. [Q9HC96-3]
    CCDS42838.1. [Q9HC96-1]
    RefSeqiNP_075571.1. NM_023083.3.
    NP_075573.2. NM_023085.3.
    UniGeneiHs.728234.

    Genome annotation databases

    EnsembliENST00000270361; ENSP00000270361; ENSG00000142330. [Q9HC96-6]
    ENST00000270364; ENSP00000270364; ENSG00000142330. [Q9HC96-7]
    ENST00000352879; ENSP00000289381; ENSG00000142330. [Q9HC96-8]
    ENST00000354082; ENSP00000270362; ENSG00000142330. [Q9HC96-3]
    ENST00000357048; ENSP00000349556; ENSG00000142330. [Q9HC96-4]
    ENST00000391983; ENSP00000375843; ENSG00000142330. [Q9HC96-2]
    ENST00000391984; ENSP00000375844; ENSG00000142330. [Q9HC96-1]
    ENST00000416591; ENSP00000400144; ENSG00000142330. [Q9HC96-5]
    GeneIDi11132.
    KEGGihsa:11132.
    UCSCiuc002vzk.2. human. [Q9HC96-1]
    uc002vzl.2. human. [Q9HC96-3]
    uc002vzm.2. human. [Q9HC96-8]
    uc002vzq.2. human. [Q9HC96-7]

    Polymorphism databases

    DMDMi317373329.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089088 mRNA. Translation: AAG17966.1 .
    AF089090 mRNA. Translation: AAG17968.1 .
    AF089091 mRNA. Translation: AAG17969.1 .
    AF089092 mRNA. Translation: AAG17970.1 .
    AF089093 mRNA. Translation: AAG17971.1 .
    AF089094 mRNA. Translation: AAG17972.1 .
    AF089095 mRNA. Translation: AAG17973.1 .
    AF089096 mRNA. Translation: AAG17974.1 .
    AB058748 mRNA. Translation: BAB47474.1 . Different initiation.
    AK074807 mRNA. Translation: BAC11220.1 .
    AC124862 Genomic DNA. Translation: AAX88944.1 .
    BC004260 mRNA. Translation: AAH04260.1 .
    BC007553 mRNA. Translation: AAH07553.2 .
    CCDSi CCDS33420.1. [Q9HC96-3 ]
    CCDS42838.1. [Q9HC96-1 ]
    RefSeqi NP_075571.1. NM_023083.3.
    NP_075573.2. NM_023085.3.
    UniGenei Hs.728234.

    3D structure databases

    ProteinModelPortali Q9HC96.
    SMRi Q9HC96. Positions 10-487, 502-638.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116305. 4 interactions.
    IntActi Q9HC96. 4 interactions.
    MINTi MINT-104261.

    Protein family/group databases

    MEROPSi C02.018.

    PTM databases

    PhosphoSitei Q9HC96.

    Polymorphism databases

    DMDMi 317373329.

    Proteomic databases

    PaxDbi Q9HC96.
    PRIDEi Q9HC96.

    Protocols and materials databases

    DNASUi 11132.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270361 ; ENSP00000270361 ; ENSG00000142330 . [Q9HC96-6 ]
    ENST00000270364 ; ENSP00000270364 ; ENSG00000142330 . [Q9HC96-7 ]
    ENST00000352879 ; ENSP00000289381 ; ENSG00000142330 . [Q9HC96-8 ]
    ENST00000354082 ; ENSP00000270362 ; ENSG00000142330 . [Q9HC96-3 ]
    ENST00000357048 ; ENSP00000349556 ; ENSG00000142330 . [Q9HC96-4 ]
    ENST00000391983 ; ENSP00000375843 ; ENSG00000142330 . [Q9HC96-2 ]
    ENST00000391984 ; ENSP00000375844 ; ENSG00000142330 . [Q9HC96-1 ]
    ENST00000416591 ; ENSP00000400144 ; ENSG00000142330 . [Q9HC96-5 ]
    GeneIDi 11132.
    KEGGi hsa:11132.
    UCSCi uc002vzk.2. human. [Q9HC96-1 ]
    uc002vzl.2. human. [Q9HC96-3 ]
    uc002vzm.2. human. [Q9HC96-8 ]
    uc002vzq.2. human. [Q9HC96-7 ]

    Organism-specific databases

    CTDi 11132.
    GeneCardsi GC02P241545.
    HGNCi HGNC:1477. CAPN10.
    HPAi HPA004170.
    MIMi 601283. phenotype.
    605286. gene.
    neXtProti NX_Q9HC96.
    PharmGKBi PA26058.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313372.
    HOVERGENi HBG050787.
    InParanoidi Q9HC96.
    KOi K08579.
    OMAi VHLRCEL.
    OrthoDBi EOG7RV9FM.
    PhylomeDBi Q9HC96.
    TreeFami TF314748.

    Miscellaneous databases

    ChiTaRSi CAPN10. human.
    GeneWikii CAPN10.
    GenomeRNAii 11132.
    NextBioi 42312.
    PROi Q9HC96.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HC96.
    Bgeei Q9HC96.
    Genevestigatori Q9HC96.

    Family and domain databases

    InterProi IPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR028791. CAPN10.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view ]
    PANTHERi PTHR10183:SF30. PTHR10183:SF30. 1 hit.
    Pfami PF01067. Calpain_III. 2 hits.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view ]
    PRINTSi PR00704. CALPAIN.
    SMARTi SM00720. calpain_III. 2 hits.
    SM00230. CysPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49758. SSF49758. 2 hits.
    PROSITEi PS50203. CALPAIN_CAT. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, VARIANTS THR-200; HIS-202; VAL-341; ALA-504; SER-529; ASN-613 AND VAL-666, INVOLVEMENT IN SUSCEPTIBILITY TO NIDDM1.
    2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A), VARIANT VAL-666.
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A), VARIANTS ALA-504 AND VAL-666.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A), VARIANT VAL-666.
      Tissue: Skin and Uterus.
    6. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    7. "A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes."
      Kang E.S., Kim H.J., Nam M., Nam C.M., Ahn C.W., Cha B.S., Lee H.C.
      J. Hum. Genet. 51:629-633(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO NIDDM1.
    8. "Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells."
      Brown A.E., Yeaman S.J., Walker M.
      Mol. Genet. Metab. 91:318-324(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-276.

    Entry informationi

    Entry nameiCAN10_HUMAN
    AccessioniPrimary (citable) accession number: Q9HC96
    Secondary accession number(s): A8MVS7
    , Q4ZFV1, Q8NCD4, Q96IG4, Q96JI2, Q9HC89, Q9HC90, Q9HC91, Q9HC92, Q9HC93, Q9HC94, Q9HC95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3