Q9HC96 (CAN10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calpain-10
EC=3.4.22.-

Alternative name(s):
Calcium-activated neutral proteinase 10
Short name=CANP 10

Gene names

Name:	CAPN10
Synonyms:	KIAA1845

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	672 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Catalytic activity	Broad endopeptidase specificity.
Tissue specificity	Ubiquitous.
Involvement in disease	Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1) [MIM:601283]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.1 Ref.8
Sequence similarities	Belongs to the peptidase C2 family. Contains 1 calpain catalytic domain.
Sequence caution	The sequence BAB47474.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Diabetes mellitus
Domain	Repeat
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin cytoskeleton reorganization Inferred from sequence or structural similarity PubMed 12974673. Source: BHF-UCL cellular response to insulin stimulus Inferred from mutant phenotype PubMed 17572128. Source: BHF-UCL positive regulation of apoptotic process Inferred from mutant phenotype PubMed 15044459. Source: BHF-UCL positive regulation of glucose import Inferred from mutant phenotype PubMed 17572128. Source: BHF-UCL positive regulation of insulin secretion Inferred from mutant phenotype PubMed 15471947. Source: BHF-UCL positive regulation of intracellular transport Inferred from sequence or structural similarity PubMed 12974673. Source: BHF-UCL proteolysis Inferred from mutant phenotype PubMed 15044459. Source: BHF-UCL
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: BHF-UCL plasma membrane Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular_function	SNARE binding Inferred from sequence or structural similarity. Source: BHF-UCL calcium-dependent cysteine-type endopeptidase activity Inferred from mutant phenotype PubMed 15044459. Source: BHF-UCL cytoskeletal protein binding Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q9HC96-1)

Also known as: CAPN10a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9HC96-2)

Also known as: CAPN10b;

The sequence of this isoform differs from the canonical sequence as follows:
     494-544: SAIRAVAKNT...FASYPTNPCF → RALAPAASAS...HPHCCCRSRC
     545-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform C (identifier: Q9HC96-3)

Also known as: CAPN10c;

The sequence of this isoform differs from the canonical sequence as follows:
     428-582: Missing.

Isoform D (identifier: Q9HC96-4)

Also known as: CAPN10d;

The sequence of this isoform differs from the canonical sequence as follows:
     494-513: SAIRAVAKNTTPGAALPAGE → RSQRVEGARTHPHCCCRSRC
     514-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform E (identifier: Q9HC96-5)

Also known as: CAPN10e;

The sequence of this isoform differs from the canonical sequence as follows:
     427-444: VEKRRVNLPRVLSMPPVA → GVTLGTTLFPVPSWMWPT
     445-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform F (identifier: Q9HC96-6)

Also known as: CAPN10f;

The sequence of this isoform differs from the canonical sequence as follows:
     154-274: VYAKVHGSYE...WGRRCWQGLW → GPWVLRAPVG...VLAGALERGG
     275-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform G (identifier: Q9HC96-7)

Also known as: CAPN10g;

The sequence of this isoform differs from the canonical sequence as follows:
     93-139: IPPGQPSWAD...CLAGRLCFSR → SCPVQLPADW...PDSATWGSWK
     140-672: Missing.

Isoform H (identifier: Q9HC96-8)

Also known as: CAPN10h;

The sequence of this isoform differs from the canonical sequence as follows:
     48-581: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 672	672	Calpain-10		PRO_0000207725
Regions
	Domain	13 – 321	309	Calpain catalytic
	Region	322 – 494	173	Domain III 1
	Region	513 – 654	142	Domain III 2
Sites
	Active site	73	1	By similarity
	Active site	238	1	By similarity
	Active site	263	1	By similarity
Natural variations
	Alternative sequence	48 – 581	534	Missing in isoform H.		VSP_005243
	Alternative sequence	93 – 139	47	IPPGQ…LCFSR → SCPVQLPADWTCKVQPVWLE FPCLPISCRLRVSSDTSPDS ATWGSWK in isoform G.		VSP_005241
	Alternative sequence	140 – 672	533	Missing in isoform G.		VSP_005242
	Alternative sequence	154 – 274	121	VYAKV…WQGLW → GPWVLRAPVGRAGGGCPGGP DRRPGRKMEPEGRSRKRRPA GQARPLGAQDLSAAAPPEGP VSDQLLRAQPQSRCPGAGGV PCLHCLGPAGAPGSGGPVHP AAADPEPLGPAVLAGALERG G in isoform F.		VSP_005239
	Alternative sequence	275 – 672	398	Missing in isoform F.		VSP_005240
	Alternative sequence	427 – 444	18	VEKRR…MPPVA → GVTLGTTLFPVPSWMWPT in isoform E.		VSP_005237
	Alternative sequence	428 – 582	155	Missing in isoform C.		VSP_005234
	Alternative sequence	445 – 672	228	Missing in isoform E.		VSP_005238
	Alternative sequence	494 – 544	51	SAIRA…TNPCF → RALAPAASASLCISTAGPVT PSSTPSASISSRSQRVEGAR THPHCCCRSRC in isoform B.		VSP_005232
	Alternative sequence	494 – 513	20	SAIRA…LPAGE → RSQRVEGARTHPHCCCRSRC in isoform D.		VSP_005235
	Alternative sequence	514 – 672	159	Missing in isoform D.		VSP_005236
	Alternative sequence	545 – 672	128	Missing in isoform B.		VSP_005233
	Natural variant	200	1	P → T. Ref.1 Corresponds to variant rs3792268 [ dbSNP | Ensembl ].		VAR_014437
	Natural variant	202	1	R → H. Ref.1		VAR_014438
	Natural variant	276	1	E → G in a colorectal cancer sample; somatic mutation. Ref.9		VAR_036049
	Natural variant	341	1	A → V. Ref.1		VAR_014439
	Natural variant	504	1	T → A. Ref.1 Ref.4 Corresponds to variant rs7607759 [ dbSNP | Ensembl ].		VAR_014440
	Natural variant	529	1	A → S. Ref.1		VAR_014441
	Natural variant	613	1	S → N. Ref.1		VAR_014442
	Natural variant	666	1	I → V. Ref.1 Ref.3 Ref.4 Ref.6 Corresponds to variant rs2975766 [ dbSNP | Ensembl ].		VAR_014443
Experimental info
	Sequence conflict	195	1	G → S in BAC11220. Ref.4
	Sequence conflict	373	1	E → K in AAG17969. Ref.1
	Sequence conflict	373	1	E → K in AAG17971. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform A (CAPN10a) [UniParc]. Last modified January 11, 2011. Version 2. Checksum: 74A48D879E896C71	FASTA	672	74,952
	10 20 30 40 50 60 MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC ATPRLFPDDP 70 80 90 100 110 120 REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW ADQEYRGSFT CRIWQFGRWV 130 140 150 160 170 180 EVTTDDRLPC LAGRLCFSRC QREDVFWLPL LEKVYAKVHG SYEHLWAGQV ADALVDLTGG 190 200 210 220 230 240 LAERWNLKGV AGSGGQQDRP GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG ARELGEFHAF 250 260 270 280 290 300 IVSDLRELQG QAGQCILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVAS ELLSQLQEGE 310 320 330 340 350 360 FWVEEEEFLR EFDELTVGYP VTEAGHLQSL YTERLLCHTR ALPGAWVKGQ SAGGCRNNSG 370 380 390 400 410 420 FPSNPKFWLR VSEPSEVYIA VLQRSRLHAA DWAGRARALV GDSHTSWSPA SIPGKHYQAV 430 440 450 460 470 480 GLHLWKVEKR RVNLPRVLSM PPVAGTACHA YDREVHLRCE LSPGYYLAVP STFLKDAPGE 490 500 510 520 530 540 FLLRVFSTGR VSLSAIRAVA KNTTPGAALP AGEWGTVQLR GSWRVGQTAG GSRNFASYPT 550 560 570 580 590 600 NPCFPFSVPE GPGPRCVRIT LHQHCRPSDT EFHPIGFHIF QVPEGGRSQD APPLLLQEPL 610 620 630 640 650 660 LSCVPHRYAQ EVSRLCLLPA GTYKVVPSTY LPDTEGAFTV TIATRIDRPS IHSQEMLGQF 670 LQEVSIMAVM KT
	Isoform B (CAPN10b) [UniParc]. Checksum: 17CE7B881A20855E	FASTA	544	60,657
	10 20 30 40 50 60 MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC ATPRLFPDDP 70 80 90 100 110 120 REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW ADQEYRGSFT CRIWQFGRWV 130 140 150 160 170 180 EVTTDDRLPC LAGRLCFSRC QREDVFWLPL LEKVYAKVHG SYEHLWAGQV ADALVDLTGG 190 200 210 220 230 240 LAERWNLKGV AGSGGQQDRP GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG ARELGEFHAF 250 260 270 280 290 300 IVSDLRELQG QAGQCILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVAS ELLSQLQEGE 310 320 330 340 350 360 FWVEEEEFLR EFDELTVGYP VTEAGHLQSL YTERLLCHTR ALPGAWVKGQ SAGGCRNNSG 370 380 390 400 410 420 FPSNPKFWLR VSEPSEVYIA VLQRSRLHAA DWAGRARALV GDSHTSWSPA SIPGKHYQAV 430 440 450 460 470 480 GLHLWKVEKR RVNLPRVLSM PPVAGTACHA YDREVHLRCE LSPGYYLAVP STFLKDAPGE 490 500 510 520 530 540 FLLRVFSTGR VSLRALAPAA SASLCISTAG PVTPSSTPSA SISSRSQRVE GARTHPHCCC RSRC
	Isoform C (CAPN10c) [UniParc]. Checksum: 8D81A0FA44993180	FASTA	517	57,999
	10 20 30 40 50 60 MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC ATPRLFPDDP 70 80 90 100 110 120 REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW ADQEYRGSFT CRIWQFGRWV 130 140 150 160 170 180 EVTTDDRLPC LAGRLCFSRC QREDVFWLPL LEKVYAKVHG SYEHLWAGQV ADALVDLTGG 190 200 210 220 230 240 LAERWNLKGV AGSGGQQDRP GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG ARELGEFHAF 250 260 270 280 290 300 IVSDLRELQG QAGQCILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVAS ELLSQLQEGE 310 320 330 340 350 360 FWVEEEEFLR EFDELTVGYP VTEAGHLQSL YTERLLCHTR ALPGAWVKGQ SAGGCRNNSG 370 380 390 400 410 420 FPSNPKFWLR VSEPSEVYIA VLQRSRLHAA DWAGRARALV GDSHTSWSPA SIPGKHYQAV 430 440 450 460 470 480 GLHLWKVPEG GRSQDAPPLL LQEPLLSCVP HRYAQEVSRL CLLPAGTYKV VPSTYLPDTE 490 500 510 GAFTVTIATR IDRPSIHSQE MLGQFLQEVS IMAVMKT
	Isoform D (CAPN10d) [UniParc]. Checksum: C66DC853F87AEC9C	FASTA	513	57,816
	10 20 30 40 50 60 MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC ATPRLFPDDP 70 80 90 100 110 120 REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW ADQEYRGSFT CRIWQFGRWV 130 140 150 160 170 180 EVTTDDRLPC LAGRLCFSRC QREDVFWLPL LEKVYAKVHG SYEHLWAGQV ADALVDLTGG 190 200 210 220 230 240 LAERWNLKGV AGSGGQQDRP GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG ARELGEFHAF 250 260 270 280 290 300 IVSDLRELQG QAGQCILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVAS ELLSQLQEGE 310 320 330 340 350 360 FWVEEEEFLR EFDELTVGYP VTEAGHLQSL YTERLLCHTR ALPGAWVKGQ SAGGCRNNSG 370 380 390 400 410 420 FPSNPKFWLR VSEPSEVYIA VLQRSRLHAA DWAGRARALV GDSHTSWSPA SIPGKHYQAV 430 440 450 460 470 480 GLHLWKVEKR RVNLPRVLSM PPVAGTACHA YDREVHLRCE LSPGYYLAVP STFLKDAPGE 490 500 510 FLLRVFSTGR VSLRSQRVEG ARTHPHCCCR SRC
	Isoform E (CAPN10e) [UniParc]. Checksum: 32E4706B7D06D58E	FASTA	444	49,994
	10 20 30 40 50 60 MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC ATPRLFPDDP 70 80 90 100 110 120 REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW ADQEYRGSFT CRIWQFGRWV 130 140 150 160 170 180 EVTTDDRLPC LAGRLCFSRC QREDVFWLPL LEKVYAKVHG SYEHLWAGQV ADALVDLTGG 190 200 210 220 230 240 LAERWNLKGV AGSGGQQDRP GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG ARELGEFHAF 250 260 270 280 290 300 IVSDLRELQG QAGQCILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVAS ELLSQLQEGE 310 320 330 340 350 360 FWVEEEEFLR EFDELTVGYP VTEAGHLQSL YTERLLCHTR ALPGAWVKGQ SAGGCRNNSG 370 380 390 400 410 420 FPSNPKFWLR VSEPSEVYIA VLQRSRLHAA DWAGRARALV GDSHTSWSPA SIPGKHYQAV 430 440 GLHLWKGVTL GTTLFPVPSW MWPT
	Isoform F (CAPN10f) [UniParc]. Checksum: 570C2A6CB9B6B903	FASTA	274	29,453
	10 20 30 40 50 60 MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC ATPRLFPDDP 70 80 90 100 110 120 REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW ADQEYRGSFT CRIWQFGRWV 130 140 150 160 170 180 EVTTDDRLPC LAGRLCFSRC QREDVFWLPL LEKGPWVLRA PVGRAGGGCP GGPDRRPGRK 190 200 210 220 230 240 MEPEGRSRKR RPAGQARPLG AQDLSAAAPP EGPVSDQLLR AQPQSRCPGA GGVPCLHCLG 250 260 270 PAGAPGSGGP VHPAAADPEP LGPAVLAGAL ERGG
	Isoform G (CAPN10g) [UniParc]. Checksum: C934A0FD16963EC6	FASTA	139	15,583
	10 20 30 40 50 60 MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC ATPRLFPDDP 70 80 90 100 110 120 REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVSCPVQLPA DWTCKVQPVW LEFPCLPISC 130 RLRVSSDTSP DSATWGSWK
	Isoform H (CAPN10h) [UniParc]. Checksum: 28589100F645B66B	FASTA	138	15,275
	10 20 30 40 50 60 MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQVPE GGRSQDAPPL 70 80 90 100 110 120 LLQEPLLSCV PHRYAQEVSR LCLLPAGTYK VVPSTYLPDT EGAFTVTIAT RIDRPSIHSQ 130 EMLGQFLQEV SIMAVMKT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus." Horikawa Y., Oda N., Cox N.J., Li X., Orho-Melander M., Hara M., Hinokio Y., Lindner T.H., Mashima H., Schwarz P.E.H., del Bosque-Plata L., Horikawa Y., Oda Y., Yoshiuchi I., Colilla S., Polonsky K.S., Wei S., Concannon P. , Iwasaki N., Schulze J., Baier L.J., Bogardus C., Groop L., Boerwinkle E., Hanis C.L., Bell G.I. Nat. Genet. 26:163-175(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, VARIANTS THR-200; HIS-202; VAL-341; ALA-504; SER-529; ASN-613 AND VAL-666, INVOLVEMENT IN SUSCEPTIBILITY TO NIDDM1.
[2]	Erratum Horikawa Y., Oda N., Cox N.J., Li X., Orho-Melander M., Hara M., Hinokio Y., Lindner T.H., Mashima H., Schwarz P.E.H., del Bosque-Plata L., Horikawa Y., Oda Y., Yoshiuchi I., Colilla S., Polonsky K.S., Wei S., Concannon P. , Iwasaki N., Schulze J., Baier L.J., Bogardus C., Groop L., Boerwinkle E., Hanis C.L., Bell G.I. Nat. Genet. 26:502-502(2000)
[3]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A), VARIANT VAL-666. Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A), VARIANTS ALA-504 AND VAL-666.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A), VARIANT VAL-666. Tissue: Skin and Uterus.
[7]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[8]	"A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes." Kang E.S., Kim H.J., Nam M., Nam C.M., Ahn C.W., Cha B.S., Lee H.C. J. Hum. Genet. 51:629-633(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO NIDDM1.
[9]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-276.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF089088 mRNA. Translation: AAG17966.1. AF089090 mRNA. Translation: AAG17968.1. AF089091 mRNA. Translation: AAG17969.1. AF089092 mRNA. Translation: AAG17970.1. AF089093 mRNA. Translation: AAG17971.1. AF089094 mRNA. Translation: AAG17972.1. AF089095 mRNA. Translation: AAG17973.1. AF089096 mRNA. Translation: AAG17974.1. AB058748 mRNA. Translation: BAB47474.1. Different initiation. AK074807 mRNA. Translation: BAC11220.1. AC124862 Genomic DNA. Translation: AAX88944.1. BC004260 mRNA. Translation: AAH04260.1. BC007553 mRNA. Translation: AAH07553.2.
IPI	IPI00183619. IPI00220233. IPI00220234. IPI00220235. IPI00220236. IPI00220238. IPI00253782. IPI00302479.
RefSeq	NP_075571.1. NM_023083.3. NP_075573.2. NM_023085.3.
UniGene	Hs.728234.
3D structure databases
ProteinModelPortal	Q9HC96.
SMR	Q9HC96. Positions 10-487, 502-638.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HC96. 4 interactions.
Protein family/group databases
MEROPS	C02.018.
PTM databases
PhosphoSite	Q9HC96.
Polymorphism databases
DMDM	21263445.
Proteomic databases
PaxDb	Q9HC96.
PRIDE	Q9HC96.
Protocols and materials databases
DNASU	11132.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000270361; ENSP00000270361; ENSG00000142330. ENST00000270364; ENSP00000270364; ENSG00000142330. ENST00000352879; ENSP00000289381; ENSG00000142330. ENST00000354082; ENSP00000270362; ENSG00000142330. ENST00000357048; ENSP00000349556; ENSG00000142330. ENST00000391982; ENSP00000375842; ENSG00000142330. ENST00000391983; ENSP00000375843; ENSG00000142330. ENST00000391984; ENSP00000375844; ENSG00000142330. ENST00000416591; ENSP00000400144; ENSG00000142330.
GeneID	11132.
KEGG	hsa:11132.
UCSC	uc002vzk.2. human. uc002vzl.2. human. uc002vzm.2. human. uc002vzq.2. human.
Organism-specific databases
CTD	11132.
GeneCards	GC02P241545.
HGNC	HGNC:1477. CAPN10.
HPA	HPA004170.
MIM	601283. phenotype. 605286. gene.
neXtProt	NX_Q9HC96.
PharmGKB	PA26058.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG313372.
HOVERGEN	HBG050787.
InParanoid	Q9HC96.
KO	K08579.
OMA	LSPGYYL.
OrthoDB	EOG4640BT.
Gene expression databases
ArrayExpress	Q9HC96.
Bgee	Q9HC96.
Genevestigator	Q9HC96.
GermOnline	ENSG00000142330. Homo sapiens.
Family and domain databases
InterPro	IPR022684. Calpain_cysteine_protease. IPR022682. Calpain_domain_III. IPR022683. Calpain_III. IPR000169. Pept_cys_AS. IPR001300. Peptidase_C2_calpain_cat. [Graphical view]
Pfam	PF01067. Calpain_III. 2 hits. PF00648. Peptidase_C2. 1 hit. [Graphical view]
PRINTS	PR00704. CALPAIN.
SMART	SM00720. calpain_III. 2 hits. SM00230. CysPc. 1 hit. [Graphical view]
SUPFAM	SSF49758. Peptidase_C2. 2 hits.
PROSITE	PS50203. CALPAIN_CAT. 1 hit. PS00640. THIOL_PROTEASE_ASN. False negative. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CAPN10. human.
GenomeRNAi	11132.
NextBio	42312.
SOURCE	Search...

Entry information

Entry name

CAN10_HUMAN

Accession

Primary (citable) accession number: Q9HC96
Secondary accession number(s): A8MVS7 , Q4ZFV1, Q8NCD4, Q96IG4, Q96JI2, Q9HC89, Q9HC90, Q9HC91, Q9HC92, Q9HC93, Q9HC94, Q9HC95

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 116 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.