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Q9HC96

- CAN10_HUMAN

UniProt

Q9HC96 - CAN10_HUMAN

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Protein

Calpain-10

Gene
CAPN10, KIAA1845
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.1 Publication

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731 By similarity
Active sitei238 – 2381 By similarity
Active sitei263 – 2631 By similarity

GO - Molecular functioni

  1. calcium-dependent cysteine-type endopeptidase activity Source: BHF-UCL
  2. cytoskeletal protein binding Source: BHF-UCL
  3. SNARE binding Source: BHF-UCL

GO - Biological processi

  1. actin cytoskeleton reorganization Source: BHF-UCL
  2. cellular component disassembly involved in execution phase of apoptosis Source: BHF-UCL
  3. cellular response to insulin stimulus Source: BHF-UCL
  4. positive regulation of glucose import Source: BHF-UCL
  5. positive regulation of insulin secretion Source: BHF-UCL
  6. positive regulation of intracellular transport Source: BHF-UCL
  7. positive regulation of type B pancreatic cell apoptotic process Source: Ensembl
  8. proteolysis Source: BHF-UCL
  9. type B pancreatic cell apoptotic process Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC02.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-10 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 10
Short name:
CANP 10
Gene namesi
Name:CAPN10
Synonyms:KIAA1845
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:1477. CAPN10.

Subcellular locationi

GO - Cellular componenti

  1. cell Source: BHF-UCL
  2. cytosol Source: BHF-UCL
  3. mitochondrion Source: BHF-UCL
  4. plasma membrane Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1) [MIM:601283]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.2 Publications

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

MIMi601283. phenotype.
PharmGKBiPA26058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 672672Calpain-10PRO_0000207725Add
BLAST

Proteomic databases

PaxDbiQ9HC96.
PRIDEiQ9HC96.

PTM databases

PhosphoSiteiQ9HC96.

Expressioni

Tissue specificityi

Detected in primary skeletal muscle cells (at protein level). Ubiquitous.1 Publication

Gene expression databases

ArrayExpressiQ9HC96.
BgeeiQ9HC96.
GenevestigatoriQ9HC96.

Organism-specific databases

HPAiHPA004170.

Interactioni

Protein-protein interaction databases

BioGridi116305. 4 interactions.
IntActiQ9HC96. 4 interactions.
MINTiMINT-104261.

Structurei

3D structure databases

ProteinModelPortaliQ9HC96.
SMRiQ9HC96. Positions 10-487, 502-638.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 321309Calpain catalyticAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni322 – 494173Domain III 1Add
BLAST
Regioni513 – 654142Domain III 2Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG313372.
HOVERGENiHBG050787.
InParanoidiQ9HC96.
KOiK08579.
OMAiVHLRCEL.
OrthoDBiEOG7RV9FM.
PhylomeDBiQ9HC96.
TreeFamiTF314748.

Family and domain databases

InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR028791. CAPN10.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF30. PTHR10183:SF30. 1 hit.
PfamiPF01067. Calpain_III. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 2 hits.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q9HC96-1) [UniParc]FASTAAdd to Basket

Also known as: CAPN10a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC    50
ATPRLFPDDP REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW 100
ADQEYRGSFT CRIWQFGRWV EVTTDDRLPC LAGRLCFSRC QREDVFWLPL 150
LEKVYAKVHG SYEHLWAGQV ADALVDLTGG LAERWNLKGV AGSGGQQDRP 200
GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG ARELGEFHAF IVSDLRELQG 250
QAGQCILLLR IQNPWGRRCW QGLWREGGEG WSQVDAAVAS ELLSQLQEGE 300
FWVEEEEFLR EFDELTVGYP VTEAGHLQSL YTERLLCHTR ALPGAWVKGQ 350
SAGGCRNNSG FPSNPKFWLR VSEPSEVYIA VLQRSRLHAA DWAGRARALV 400
GDSHTSWSPA SIPGKHYQAV GLHLWKVEKR RVNLPRVLSM PPVAGTACHA 450
YDREVHLRCE LSPGYYLAVP STFLKDAPGE FLLRVFSTGR VSLSAIRAVA 500
KNTTPGAALP AGEWGTVQLR GSWRVGQTAG GSRNFASYPT NPCFPFSVPE 550
GPGPRCVRIT LHQHCRPSDT EFHPIGFHIF QVPEGGRSQD APPLLLQEPL 600
LSCVPHRYAQ EVSRLCLLPA GTYKVVPSTY LPDTEGAFTV TIATRIDRPS 650
IHSQEMLGQF LQEVSIMAVM KT 672
Length:672
Mass (Da):74,952
Last modified:January 11, 2011 - v2
Checksum:i74A48D879E896C71
GO
Isoform B (identifier: Q9HC96-2) [UniParc]FASTAAdd to Basket

Also known as: CAPN10b

The sequence of this isoform differs from the canonical sequence as follows:
     494-544: SAIRAVAKNT...FASYPTNPCF → RALAPAASAS...HPHCCCRSRC
     545-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:544
Mass (Da):60,657
Checksum:i17CE7B881A20855E
GO
Isoform C (identifier: Q9HC96-3) [UniParc]FASTAAdd to Basket

Also known as: CAPN10c

The sequence of this isoform differs from the canonical sequence as follows:
     428-582: Missing.

Show »
Length:517
Mass (Da):57,999
Checksum:i8D81A0FA44993180
GO
Isoform D (identifier: Q9HC96-4) [UniParc]FASTAAdd to Basket

Also known as: CAPN10d

The sequence of this isoform differs from the canonical sequence as follows:
     494-513: SAIRAVAKNTTPGAALPAGE → RSQRVEGARTHPHCCCRSRC
     514-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:513
Mass (Da):57,816
Checksum:iC66DC853F87AEC9C
GO
Isoform E (identifier: Q9HC96-5) [UniParc]FASTAAdd to Basket

Also known as: CAPN10e

The sequence of this isoform differs from the canonical sequence as follows:
     427-444: VEKRRVNLPRVLSMPPVA → GVTLGTTLFPVPSWMWPT
     445-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:444
Mass (Da):49,994
Checksum:i32E4706B7D06D58E
GO
Isoform F (identifier: Q9HC96-6) [UniParc]FASTAAdd to Basket

Also known as: CAPN10f

The sequence of this isoform differs from the canonical sequence as follows:
     154-274: VYAKVHGSYE...WGRRCWQGLW → GPWVLRAPVG...VLAGALERGG
     275-672: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:274
Mass (Da):29,453
Checksum:i570C2A6CB9B6B903
GO
Isoform G (identifier: Q9HC96-7) [UniParc]FASTAAdd to Basket

Also known as: CAPN10g

The sequence of this isoform differs from the canonical sequence as follows:
     93-139: IPPGQPSWAD...CLAGRLCFSR → SCPVQLPADW...PDSATWGSWK
     140-672: Missing.

Show »
Length:139
Mass (Da):15,583
Checksum:iC934A0FD16963EC6
GO
Isoform H (identifier: Q9HC96-8) [UniParc]FASTAAdd to Basket

Also known as: CAPN10h

The sequence of this isoform differs from the canonical sequence as follows:
     48-581: Missing.

Show »
Length:138
Mass (Da):15,275
Checksum:i28589100F645B66B
GO

Sequence cautioni

The sequence BAB47474.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti200 – 2001P → T.1 Publication
Corresponds to variant rs3792268 [ dbSNP | Ensembl ].
VAR_014437
Natural varianti202 – 2021R → H.1 Publication
VAR_014438
Natural varianti276 – 2761E → G in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036049
Natural varianti341 – 3411A → V.1 Publication
VAR_014439
Natural varianti504 – 5041T → A.2 Publications
Corresponds to variant rs7607759 [ dbSNP | Ensembl ].
VAR_014440
Natural varianti529 – 5291A → S.1 Publication
VAR_014441
Natural varianti613 – 6131S → N.1 Publication
Corresponds to variant rs146148004 [ dbSNP | Ensembl ].
VAR_014442
Natural varianti666 – 6661I → V.4 Publications
Corresponds to variant rs2975766 [ dbSNP | Ensembl ].
VAR_014443

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei48 – 581534Missing in isoform H. VSP_005243Add
BLAST
Alternative sequencei93 – 13947IPPGQ…LCFSR → SCPVQLPADWTCKVQPVWLE FPCLPISCRLRVSSDTSPDS ATWGSWK in isoform G. VSP_005241Add
BLAST
Alternative sequencei140 – 672533Missing in isoform G. VSP_005242Add
BLAST
Alternative sequencei154 – 274121VYAKV…WQGLW → GPWVLRAPVGRAGGGCPGGP DRRPGRKMEPEGRSRKRRPA GQARPLGAQDLSAAAPPEGP VSDQLLRAQPQSRCPGAGGV PCLHCLGPAGAPGSGGPVHP AAADPEPLGPAVLAGALERG G in isoform F. VSP_005239Add
BLAST
Alternative sequencei275 – 672398Missing in isoform F. VSP_005240Add
BLAST
Alternative sequencei427 – 44418VEKRR…MPPVA → GVTLGTTLFPVPSWMWPT in isoform E. VSP_005237Add
BLAST
Alternative sequencei428 – 582155Missing in isoform C. VSP_005234Add
BLAST
Alternative sequencei445 – 672228Missing in isoform E. VSP_005238Add
BLAST
Alternative sequencei494 – 54451SAIRA…TNPCF → RALAPAASASLCISTAGPVT PSSTPSASISSRSQRVEGAR THPHCCCRSRC in isoform B. VSP_005232Add
BLAST
Alternative sequencei494 – 51320SAIRA…LPAGE → RSQRVEGARTHPHCCCRSRC in isoform D. VSP_005235Add
BLAST
Alternative sequencei514 – 672159Missing in isoform D. VSP_005236Add
BLAST
Alternative sequencei545 – 672128Missing in isoform B. VSP_005233Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951G → S in BAC11220. 1 Publication
Sequence conflicti373 – 3731E → K in AAG17969. 1 Publication
Sequence conflicti373 – 3731E → K in AAG17971. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF089088 mRNA. Translation: AAG17966.1.
AF089090 mRNA. Translation: AAG17968.1.
AF089091 mRNA. Translation: AAG17969.1.
AF089092 mRNA. Translation: AAG17970.1.
AF089093 mRNA. Translation: AAG17971.1.
AF089094 mRNA. Translation: AAG17972.1.
AF089095 mRNA. Translation: AAG17973.1.
AF089096 mRNA. Translation: AAG17974.1.
AB058748 mRNA. Translation: BAB47474.1. Different initiation.
AK074807 mRNA. Translation: BAC11220.1.
AC124862 Genomic DNA. Translation: AAX88944.1.
BC004260 mRNA. Translation: AAH04260.1.
BC007553 mRNA. Translation: AAH07553.2.
CCDSiCCDS33420.1. [Q9HC96-3]
CCDS42838.1. [Q9HC96-1]
RefSeqiNP_075571.1. NM_023083.3.
NP_075573.2. NM_023085.3.
UniGeneiHs.728234.

Genome annotation databases

EnsembliENST00000270361; ENSP00000270361; ENSG00000142330. [Q9HC96-6]
ENST00000270364; ENSP00000270364; ENSG00000142330. [Q9HC96-7]
ENST00000352879; ENSP00000289381; ENSG00000142330. [Q9HC96-8]
ENST00000354082; ENSP00000270362; ENSG00000142330. [Q9HC96-3]
ENST00000357048; ENSP00000349556; ENSG00000142330. [Q9HC96-4]
ENST00000391982; ENSP00000375842; ENSG00000142330. [Q9HC96-5]
ENST00000391983; ENSP00000375843; ENSG00000142330. [Q9HC96-2]
ENST00000391984; ENSP00000375844; ENSG00000142330. [Q9HC96-1]
ENST00000416591; ENSP00000400144; ENSG00000142330. [Q9HC96-5]
GeneIDi11132.
KEGGihsa:11132.
UCSCiuc002vzk.2. human. [Q9HC96-1]
uc002vzl.2. human. [Q9HC96-3]
uc002vzm.2. human. [Q9HC96-8]
uc002vzq.2. human. [Q9HC96-7]

Polymorphism databases

DMDMi317373329.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF089088 mRNA. Translation: AAG17966.1 .
AF089090 mRNA. Translation: AAG17968.1 .
AF089091 mRNA. Translation: AAG17969.1 .
AF089092 mRNA. Translation: AAG17970.1 .
AF089093 mRNA. Translation: AAG17971.1 .
AF089094 mRNA. Translation: AAG17972.1 .
AF089095 mRNA. Translation: AAG17973.1 .
AF089096 mRNA. Translation: AAG17974.1 .
AB058748 mRNA. Translation: BAB47474.1 . Different initiation.
AK074807 mRNA. Translation: BAC11220.1 .
AC124862 Genomic DNA. Translation: AAX88944.1 .
BC004260 mRNA. Translation: AAH04260.1 .
BC007553 mRNA. Translation: AAH07553.2 .
CCDSi CCDS33420.1. [Q9HC96-3 ]
CCDS42838.1. [Q9HC96-1 ]
RefSeqi NP_075571.1. NM_023083.3.
NP_075573.2. NM_023085.3.
UniGenei Hs.728234.

3D structure databases

ProteinModelPortali Q9HC96.
SMRi Q9HC96. Positions 10-487, 502-638.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116305. 4 interactions.
IntActi Q9HC96. 4 interactions.
MINTi MINT-104261.

Protein family/group databases

MEROPSi C02.018.

PTM databases

PhosphoSitei Q9HC96.

Polymorphism databases

DMDMi 317373329.

Proteomic databases

PaxDbi Q9HC96.
PRIDEi Q9HC96.

Protocols and materials databases

DNASUi 11132.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000270361 ; ENSP00000270361 ; ENSG00000142330 . [Q9HC96-6 ]
ENST00000270364 ; ENSP00000270364 ; ENSG00000142330 . [Q9HC96-7 ]
ENST00000352879 ; ENSP00000289381 ; ENSG00000142330 . [Q9HC96-8 ]
ENST00000354082 ; ENSP00000270362 ; ENSG00000142330 . [Q9HC96-3 ]
ENST00000357048 ; ENSP00000349556 ; ENSG00000142330 . [Q9HC96-4 ]
ENST00000391982 ; ENSP00000375842 ; ENSG00000142330 . [Q9HC96-5 ]
ENST00000391983 ; ENSP00000375843 ; ENSG00000142330 . [Q9HC96-2 ]
ENST00000391984 ; ENSP00000375844 ; ENSG00000142330 . [Q9HC96-1 ]
ENST00000416591 ; ENSP00000400144 ; ENSG00000142330 . [Q9HC96-5 ]
GeneIDi 11132.
KEGGi hsa:11132.
UCSCi uc002vzk.2. human. [Q9HC96-1 ]
uc002vzl.2. human. [Q9HC96-3 ]
uc002vzm.2. human. [Q9HC96-8 ]
uc002vzq.2. human. [Q9HC96-7 ]

Organism-specific databases

CTDi 11132.
GeneCardsi GC02P241545.
HGNCi HGNC:1477. CAPN10.
HPAi HPA004170.
MIMi 601283. phenotype.
605286. gene.
neXtProti NX_Q9HC96.
PharmGKBi PA26058.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313372.
HOVERGENi HBG050787.
InParanoidi Q9HC96.
KOi K08579.
OMAi VHLRCEL.
OrthoDBi EOG7RV9FM.
PhylomeDBi Q9HC96.
TreeFami TF314748.

Miscellaneous databases

ChiTaRSi CAPN10. human.
GeneWikii CAPN10.
GenomeRNAii 11132.
NextBioi 42312.
PROi Q9HC96.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9HC96.
Bgeei Q9HC96.
Genevestigatori Q9HC96.

Family and domain databases

InterProi IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR028791. CAPN10.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view ]
PANTHERi PTHR10183:SF30. PTHR10183:SF30. 1 hit.
Pfami PF01067. Calpain_III. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view ]
PRINTSi PR00704. CALPAIN.
SMARTi SM00720. calpain_III. 2 hits.
SM00230. CysPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49758. SSF49758. 2 hits.
PROSITEi PS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, VARIANTS THR-200; HIS-202; VAL-341; ALA-504; SER-529; ASN-613 AND VAL-666, INVOLVEMENT IN SUSCEPTIBILITY TO NIDDM1.
  2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A), VARIANT VAL-666.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A), VARIANTS ALA-504 AND VAL-666.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A), VARIANT VAL-666.
    Tissue: Skin and Uterus.
  6. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  7. "A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes."
    Kang E.S., Kim H.J., Nam M., Nam C.M., Ahn C.W., Cha B.S., Lee H.C.
    J. Hum. Genet. 51:629-633(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO NIDDM1.
  8. "Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells."
    Brown A.E., Yeaman S.J., Walker M.
    Mol. Genet. Metab. 91:318-324(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-276.

Entry informationi

Entry nameiCAN10_HUMAN
AccessioniPrimary (citable) accession number: Q9HC96
Secondary accession number(s): A8MVS7
, Q4ZFV1, Q8NCD4, Q96IG4, Q96JI2, Q9HC89, Q9HC90, Q9HC91, Q9HC92, Q9HC93, Q9HC94, Q9HC95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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