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Q9HC84 (MUC5B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mucin-5B

Short name=MUC-5B
Alternative name(s):
Cervical mucin
High molecular weight salivary mucin MG1
Mucin-5 subtype B, tracheobronchial
Sublingual gland mucin
Gene names
Name:MUC5B
Synonyms:MUC5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length5762 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.

Subcellular location

Secreted.

Tissue specificity

Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas. Ref.1 Ref.6 Ref.7 Ref.8

Induction

Regulated by all-trans-retinoic acid (ATRA) in a cell-type specific manner. Ref.1

Domain

The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.

Post-translational modification

Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc2Hex1HexNac1-ol. Ref.10 Ref.11

Involvement in disease

Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (Ref.13). Ref.13 Ref.14

Sequence similarities

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 3 HAT repeats.

Contains 3 TIL (trypsin inhibitory-like) domains.

Contains 3 VWFC domains.

Contains 4 VWFD domains.

Sequence caution

The sequence CAA06167.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processO-glycan processing

Traceable author statement. Source: Reactome

cellular protein metabolic process

Traceable author statement. Source: Reactome

post-translational protein modification

Traceable author statement. Source: Reactome

   Cellular_componentGolgi lumen

Traceable author statement. Source: Reactome

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 1718282. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 57625737Mucin-5B
PRO_0000019283

Regions

Domain76 – 277202VWFD 1
Domain329 – 38557TIL 1
Domain424 – 638215VWFD 2
Domain695 – 75258TIL 2
Domain805 – 85551TIL 3
Domain855 – 92773VWFC 1
Domain894 – 1099206VWFD 3
Repeat1333 – 1432100Cys-rich subdomain 1
Repeat1503 – 1604102Cys-rich subdomain 2
Repeat1784 – 1885102Cys-rich subdomain 3
Repeat2313 – 2414102Cys-rich subdomain 4
Repeat2854 – 288633HAT 1
Repeat2871 – 2971101Cys-rich subdomain 5
Repeat3554 – 358633HAT 2
Repeat3571 – 3671101Cys-rich subdomain 6
Repeat4111 – 414333HAT 3
Repeat4128 – 4228101Cys-rich subdomain 7
Domain5074 – 5305232VWFD 4
Domain5412 – 548473VWFC 2
Domain5521 – 558767VWFC 3
Domain5653 – 574290CTCK
Region1333 – 422828967 X Cys-rich subdomain repeats
Region1890 – 219931011 X approximate tandem repeats, Ser/Thr-rich
Region2419 – 275633811 X approximate tandem repeats, Ser/Thr-rich
Region2976 – 345648117 X approximate tandem repeats, Ser/Thr-rich
Region3676 – 401333811 X approximate tandem repeats, Ser/Thr-rich
Region4233 – 487964723 X approximate tandem repeats, Ser/Thr-rich
Compositional bias1109 – 1261153Cys-rich
Compositional bias1456 – 150247Thr-rich
Compositional bias1608 – 49323325Thr-rich

Amino acid modifications

Glycosylation1451N-linked (GlcNAc...) Ref.12
Glycosylation2011N-linked (GlcNAc...) Potential
Glycosylation2541N-linked (GlcNAc...) Ref.12
Glycosylation4011N-linked (GlcNAc...) Potential
Glycosylation5151N-linked (GlcNAc...) Potential
Glycosylation8051N-linked (GlcNAc...) Potential
Glycosylation9291N-linked (GlcNAc...) Potential
Glycosylation12761N-linked (GlcNAc...) Potential
Glycosylation12921N-linked (GlcNAc...) Potential
Glycosylation13401C-linked (Man) Probable
Glycosylation15091C-linked (Man) Probable
Glycosylation15561N-linked (GlcNAc...) Ref.12
Glycosylation17741N-linked (GlcNAc...) Potential
Glycosylation17901C-linked (Man) Probable
Glycosylation23201C-linked (Man) Probable
Glycosylation27491N-linked (GlcNAc...) Potential
Glycosylation28771C-linked (Man) Probable
Glycosylation34491N-linked (GlcNAc...) Potential
Glycosylation35771C-linked (Man) Probable
Glycosylation40061N-linked (GlcNAc...) Potential
Glycosylation41341C-linked (Man) Probable
Glycosylation48041N-linked (GlcNAc...) Potential
Glycosylation49601N-linked (GlcNAc...) Ref.12
Glycosylation50171N-linked (GlcNAc...) Ref.12
Glycosylation50241N-linked (GlcNAc...) Ref.12
Glycosylation50461N-linked (GlcNAc...) Ref.12
Glycosylation50961N-linked (GlcNAc...) Ref.12
Glycosylation51111N-linked (GlcNAc...) Ref.12
Glycosylation52151N-linked (GlcNAc...) Ref.12
Glycosylation54861N-linked (GlcNAc...) Potential
Glycosylation55261N-linked (GlcNAc...) Potential
Glycosylation55651N-linked (GlcNAc...) Potential
Glycosylation55661N-linked (GlcNAc...) Potential
Glycosylation56021N-linked (GlcNAc...) Potential
Glycosylation56121N-linked (GlcNAc...) Potential
Glycosylation56631N-linked (GlcNAc...) Potential
Glycosylation56771N-linked (GlcNAc...) Potential
Glycosylation57211N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 107 By similarity
Disulfide bond447 ↔ 455 By similarity
Disulfide bond5653 ↔ 5705 By similarity
Disulfide bond5672 ↔ 5719 By similarity
Disulfide bond5681 ↔ 5735 By similarity
Disulfide bond5685 ↔ 5737 By similarity
Disulfide bond? ↔ 5741 By similarity

Natural variations

Natural variant341E → G. Ref.1 Ref.3
Corresponds to variant rs2672785 [ dbSNP | Ensembl ].
VAR_063616
Natural variant511R → W.
Corresponds to variant rs2075853 [ dbSNP | Ensembl ].
VAR_056588
Natural variant13601T → M.
Corresponds to variant rs12363494 [ dbSNP | Ensembl ].
VAR_059538
Natural variant14011R → H.
Corresponds to variant rs10835639 [ dbSNP | Ensembl ].
VAR_059539
Natural variant18051G → S. Ref.4
Corresponds to variant rs1541314 [ dbSNP | Ensembl ].
VAR_063617
Natural variant18891P → L. Ref.4
Corresponds to variant rs2943510 [ dbSNP | Ensembl ].
VAR_063618
Natural variant20251A → T. Ref.4
Corresponds to variant rs34739266 [ dbSNP | Ensembl ].
VAR_063619
Natural variant20271A → T.
Corresponds to variant rs2943531 [ dbSNP | Ensembl ].
VAR_059540
Natural variant21941M → T. Ref.4
Corresponds to variant rs2943502 [ dbSNP | Ensembl ].
VAR_063620
Natural variant22381L → P. Ref.4
Corresponds to variant rs4963031 [ dbSNP | Ensembl ].
VAR_063621
Natural variant24251M → T. Ref.4
Corresponds to variant rs3965632 [ dbSNP | Ensembl ].
VAR_063622
Natural variant25591T → M.
Corresponds to variant rs2860722 [ dbSNP | Ensembl ].
VAR_059541
Natural variant30721F → S. Ref.4
Corresponds to variant rs3021161 [ dbSNP | Ensembl ].
VAR_063623
Natural variant32841T → A. Ref.4
Corresponds to variant rs2943531 [ dbSNP | Ensembl ].
VAR_063624
Natural variant34681R → P. Ref.4
Corresponds to variant rs2943529 [ dbSNP | Ensembl ].
VAR_063625
Natural variant38161T → M. Ref.4
Corresponds to variant rs75917341 [ dbSNP | Ensembl ].
VAR_063626
Natural variant44041A → G. Ref.4
Corresponds to variant rs2943517 [ dbSNP | Ensembl ].
VAR_063627
Natural variant44401P → L. Ref.4
Corresponds to variant rs2943516 [ dbSNP | Ensembl ].
VAR_063628
Natural variant47061T → P. Ref.4
Corresponds to variant rs2943512 [ dbSNP | Ensembl ].
VAR_063629
Natural variant47121T → M. Ref.4
Corresponds to variant rs2943511 [ dbSNP | Ensembl ].
VAR_063630
Natural variant48671A → T. Ref.4
Corresponds to variant rs3021155 [ dbSNP | Ensembl ].
VAR_063631
Natural variant48821T → A. Ref.4
Corresponds to variant rs3021156 [ dbSNP | Ensembl ].
VAR_063632
Natural variant51961S → T. Ref.9
Corresponds to variant rs2672788 [ dbSNP | Ensembl ].
VAR_014123

Experimental info

Mutagenesis17901W → A: Poorly secreted. Ref.11
Sequence conflict95 – 1006FPGLCN → LPCLCK in AAC67545. Ref.2
Sequence conflict1041S → C in AAC67545. Ref.2
Sequence conflict1421E → K in AAG33673. Ref.1
Sequence conflict2251R → S in AAC67545. Ref.2
Sequence conflict330 – 3312PL → T in AAC67545. Ref.2
Sequence conflict3371E → N in AAC67545. Ref.2
Sequence conflict3561E → K in AAC67545. Ref.2
Sequence conflict3621G → R in AAC67545. Ref.2
Sequence conflict3681G → GS in AAG33673. Ref.1
Sequence conflict3731D → N in AAC67545. Ref.2
Sequence conflict392 – 3932RT → TR in AAC67545. Ref.2
Sequence conflict467 – 4682RK → GR in AAC67545. Ref.2
Sequence conflict5111L → P in AAC67545. Ref.2
Sequence conflict584 – 5863GAA → AH in CAA06167. Ref.3
Sequence conflict6001A → S in CAA06167. Ref.3
Sequence conflict627 – 6282DP → RS in AAC67545. Ref.2
Sequence conflict6321F → L in AAC67545. Ref.2
Sequence conflict6751A → P in CAA06167. Ref.3
Sequence conflict7001R → P in CAA06167. Ref.3
Sequence conflict7511E → K in AAC67545. Ref.2
Sequence conflict8111P → L in AAC67545. Ref.2
Sequence conflict816 – 8172LR → DG in AAC67545. Ref.2
Sequence conflict859 – 8602HN → NK in AAC67545. Ref.2
Sequence conflict8661P → L in AAC67545. Ref.2
Sequence conflict8721V → F in AAC67545. Ref.2
Sequence conflict8831R → T in AAC67545. Ref.2
Sequence conflict8891R → G in CAA06167. Ref.3
Sequence conflict10201G → A in AAC67545. Ref.2
Sequence conflict10821Q → E in AAC67545. Ref.2
Sequence conflict11441S → C in CAA06167. Ref.3
Sequence conflict11951G → R in AAC67545. Ref.2
Sequence conflict12071Missing in AAC67545. Ref.2
Sequence conflict12911S → T in CAA06167. Ref.3
Sequence conflict13171Missing in AAC67545. Ref.2
Sequence conflict1675 – 16773TTP → RQS in CAA96577. Ref.4
Sequence conflict1926 – 19272PT → AS in CAA96577. Ref.4
Sequence conflict1930 – 19312LR → QA in CAA96577. Ref.4
Sequence conflict1934 – 19407PPPKVLT → GTPHVS in CAA96577. Ref.4
Sequence conflict19561S → F in CAA96577. Ref.4
Sequence conflict1980 – 19823VTP → FTA in CAA96577. Ref.4
Sequence conflict20021T → M in CAA96577. Ref.4
Sequence conflict20171A → V in CAA96577. Ref.4
Sequence conflict20521P → L in CAA96577. Ref.4
Sequence conflict2069 – 20735TALTP → RARTL in CAA96577. Ref.4
Sequence conflict21021A → P in CAA96577. Ref.4
Sequence conflict21741N → S in CAA96577. Ref.4
Sequence conflict22031P → S in CAA96577. Ref.4
Sequence conflict22111R → C in CAA96577. Ref.4
Sequence conflict22331V → G in CAA96577. Ref.4
Sequence conflict23001S → Q in CAA96577. Ref.4
Sequence conflict23331P → S in AAB61398. Ref.6
Sequence conflict2456 – 249742SSTPG…TPHVS → TSTLRTAPPPKVLT in CAA96577. Ref.4
Sequence conflict2461 – 24622TT → DD in AAB61398. Ref.6
Sequence conflict2468 – 36951228Missing in AAB61398. Ref.6
Sequence conflict25131F → S in CAA96577. Ref.4
Sequence conflict2537 – 25393FTA → VTP in CAA96577. Ref.4
Sequence conflict25741V → A in CAA96577. Ref.4
Sequence conflict25821T → A in CAA96577. Ref.4
Sequence conflict26091L → P in CAA96577. Ref.4
Sequence conflict2628 – 26303RTL → LTP in CAA96577. Ref.4
Sequence conflict26591P → A in CAA96577. Ref.4
Sequence conflict27131T → R in CAA96577. Ref.4
Sequence conflict28341R → T in CAA96577. Ref.4
Sequence conflict30281T → Q in CAA96577. Ref.4
Sequence conflict3080 – 30867LPEQTTT → SQNRPPH in CAA96577. Ref.4
Sequence conflict3148 – 31525TGPTA → LPHG in CAA96577. Ref.4
Sequence conflict32891Missing in CAA96577. Ref.4
Sequence conflict34901V → G in CAA96577. Ref.4
Sequence conflict35001S → G in CAA96577. Ref.4
Sequence conflict35041H → P in CAA96577. Ref.4
Sequence conflict3716 – 374732PGTTW…STQAT → QGPP in CAA96577. Ref.4
Sequence conflict38111Q → P in AAB61398. Ref.6
Sequence conflict38311A → V in CAA96577. Ref.4
Sequence conflict38451R → G in CAA96577. Ref.4
Sequence conflict39091V → I in CAA96577. Ref.4
Sequence conflict3924 – 39252TT → QP in CAA96577. Ref.4
Sequence conflict39751V → E in CAA96577. Ref.4
Sequence conflict4060 – 40612QH → TT in CAA96577. Ref.4
Sequence conflict41141S → Q in CAA96577. Ref.4
Sequence conflict41771Q → T in CAA96577. Ref.4
Sequence conflict43131S → T in CAA52910. Ref.4
Sequence conflict43731Missing in CAA96577. Ref.4
Sequence conflict4461 – 44633VPT → APP in CAA96577. Ref.4
Sequence conflict45671A → T in CAA96577. Ref.4
Sequence conflict47801T → P in AAC51344. Ref.7
Sequence conflict51341R → A in AAB65151. Ref.8
Sequence conflict51641Q → P in AAB65151. Ref.8
Sequence conflict51871R → A in AAC51344. Ref.7
Sequence conflict51871R → A in AAB65151. Ref.8
Sequence conflict52891P → L in AAB65151. Ref.8
Sequence conflict5304 – 53063NLV → TLL in AAB65151. Ref.8
Sequence conflict53331A → R in AAC51344. Ref.7
Sequence conflict53971D → N in AAC51343. Ref.7
Sequence conflict53971D → N in AAC51344. Ref.7
Sequence conflict54741E → R in CAA70926. Ref.9
Sequence conflict54751N → T in AAB65151. Ref.8
Sequence conflict56201A → S in AAB65151. Ref.8
Sequence conflict56321A → D in AAC51343. Ref.7
Sequence conflict56601V → C in AAB65151. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Q9HC84 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 1FEC7CDCD0ADA81C

FASTA5,762596,340
        10         20         30         40         50         60 
MGAPSACRTL VLALAAMLVV PQAETQGPVE PSWENAGHTM DGGAPTSSPT RRVSFVPPVT 

        70         80         90        100        110        120 
VFPSLSPLNP AHNGRVCSTW GDFHYKTFDG DVFRFPGLCN YVFSEHCRAA YEDFNVQLRR 

       130        140        150        160        170        180 
GLVGSRPVVT RVVIKAQGLV LEASNGSVLI NGQREELPYS RTGLLVEQSG DYIKVSIRLV 

       190        200        210        220        230        240 
LTFLWNGEDS ALLELDPKYA NQTCGLCGDF NGLPAFNEFY AHNARLTPLQ FGNLQKLDGP 

       250        260        270        280        290        300 
TEQCPDPLPL PAGNCTDEEG ICHRTLLGPA FAECHALVDS TAYLAACAQD LCRCPTCPCA 

       310        320        330        340        350        360 
TFVEYSRQCA HAGGQPRNWR CPELCPRTCP LNMQHQECGS PCTDTCSNPQ RAQLCEDHCV 

       370        380        390        400        410        420 
DGCFCPPGTV LDDITHSGCL PLGQCPCTHG GRTYSPGTSF NTTCSSCTCS GGLWQCQDLP 

       430        440        450        460        470        480 
CPGTCSVQGG AHISTYDEKL YDLHGDCSYV LSKKCADSSF TVLAELRKCG LTDNENCLKA 

       490        500        510        520        530        540 
VTLSLDGGDT AIRVQADGGV FLNSIYTQLP LSAANITLFT PSSFFIVVQT GLGLQLLVQL 

       550        560        570        580        590        600 
VPLMQVFVRL DPAHQGQMCG LCGNFNQNQA DDFTALSGVV EATGAAFANT WKAQAACANA 

       610        620        630        640        650        660 
RNSFEDPCSL SVENENYARH WCSRLTDPNS AFSRCHSIIN PKPFHSNCMF DTCNCERSED 

       670        680        690        700        710        720 
CLCAALSSYV HACAAKGVQL SDWRDGVCTK YMQNCPKSQR YAYVVDACQP TCRGLSEADV 

       730        740        750        760        770        780 
TCSVSFVPVD GCTCPAGTFL NDAGACVPAQ ECPCYAHGTV LAPGEVVHDE GAVCSCTGGK 

       790        800        810        820        830        840 
LSCLGASLQK STGCAAPMVY LDCSNSSAGT PGAECLRSCH TLDVGCFSTH CVSGCVCPPG 

       850        860        870        880        890        900 
LVSDGSGGCI AEEDCPCVHN EATYKPGETI RVDCNTCTCR NRRWECSHRL CLGTCVAYGD 

       910        920        930        940        950        960 
GHFITFDGDR YSFEGSCEYI LAQDYCGDNT THGTFRIVTE NIPCGTTGTT CSKAIKLFVE 

       970        980        990       1000       1010       1020 
SYELILQEGT FKAVARGPGG DPPYKIRYMG IFLVIETHGM AVSWDRKTSV FIRLHQDYKG 

      1030       1040       1050       1060       1070       1080 
RVCGLCGNFD DNAINDFATR SRSVVGDALE FGNSWKLSPS CPDALAPKDP CTANPFRKSW 

      1090       1100       1110       1120       1130       1140 
AQKQCSILHG PTFAACRSQV DSTKYYEACV NDACACDSGG DCECFCTAVA AYAQACHDAG 

      1150       1160       1170       1180       1190       1200 
LCVSWRTPDT CPLFCDFYNP HGGCEWHYQP CGAPCLKTCR NPSGHCLVDL PGLEGCYPKC 

      1210       1220       1230       1240       1250       1260 
PPSQPFFNED QMKCVAQCGC YDKDGNYYDV GARVPTAENC QSCNCTPSGI QCAHSLEACT 

      1270       1280       1290       1300       1310       1320 
CTYEDRTYSY QDVIYNTTDG LGACLIAICG SNGTIIRKAV ACPGTPATTP FTFTTAWVPH 

      1330       1340       1350       1360       1370       1380 
STTSPALPVS TVCVREVCRW SSWYNGHRPE PGLGGGDFET FENLRQRGYQ VCPVLADIEC 

      1390       1400       1410       1420       1430       1440 
RAAQLPDMPL EELGQQVDCD RMRGLMCANS QQSPPLCHDY ELRVLCCEYV PCGPSPAPGT 

      1450       1460       1470       1480       1490       1500 
SPQPSLSAST EPAVPTPTQT TATEKTTLWV TPSIRSTAAL TSQTGSSSGP VTVTPSAPGT 

      1510       1520       1530       1540       1550       1560 
TTCQPRCQWT EWFDEDYPKS EQLGGDVESY DKIRAAGGHL CQQPKDIECQ AESFPNWTLA 

      1570       1580       1590       1600       1610       1620 
QVGQKVHCDV HFGLVCRNWE QEGVFKMCYN YRIRVLCCSD DHCRGRATTP PPTTELETAT 

      1630       1640       1650       1660       1670       1680 
TTTTQALFST PQPTSSPGLT RAPPASTTAV PTLSEGLTSP RYTSTLGTAT TGGPTTPAGS 

      1690       1700       1710       1720       1730       1740 
TEPTVPGVAT STLPTRSALP GTTGSLGTWR PSQPPTLAPT TMATSRARPT GTASTASKEP 

      1750       1760       1770       1780       1790       1800 
LTTSLAPTLT SELSTSQAET STPRTETTMS PLTNTTTSQG TTRCQPKCEW TEWFDVDFPT 

      1810       1820       1830       1840       1850       1860 
SGVAGGDMET FENIRAAGGK MCWAPKSIEC RAENYPEVSI DQVGQVLTCS LETGLTCKNE 

      1870       1880       1890       1900       1910       1920 
DQTGRFNMCF NYNVRVLCCD DYSHCPSTPA TSSTATPSST PGTTWILTKP TTTATTTAST 

      1930       1940       1950       1960       1970       1980 
GSTATPTSTL RTAPPPKVLT TTATTPTVTS SKATPSSSPG TATALPALRS TATTPTATSV 

      1990       2000       2010       2020       2030       2040 
TPIPSSSLGT TWTRLSQTTT PTATMSTATP SSTPETAHTS TVLTATATTT GATGSVATPS 

      2050       2060       2070       2080       2090       2100 
STPGTAHTTK VPTTTTTGFT ATPSSSPGTA LTPPVWISTT TTPTTRGSTV TPSSIPGTTH 

      2110       2120       2130       2140       2150       2160 
TATVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI TATGSTTNPS STPGTTPIPP 

      2170       2180       2190       2200       2210       2220 
VLTTTATTPA ATSNTVTPSS ALGTTHTPPV PNTMATTHGR SLPPSSPHTV RTAWTSATSG 

      2230       2240       2250       2260       2270       2280 
ILGTTHITEP STVTSHTLAA TTGTTQHSTP ALSSPHPSSR TTESPPSPGT TTPGHTTATS 

      2290       2300       2310       2320       2330       2340 
RTTATATPSK TRTSTLLPSS PTSAPITTVV TMGCEPQCAW SEWLDYSYPM PGPSGGDFDT 

      2350       2360       2370       2380       2390       2400 
YSNIRAAGGA VCEQPLGLEC RAQAQPGVPL RELGQVVECS LDFGLVCRNR EQVGKFKMCF 

      2410       2420       2430       2440       2450       2460 
NYEIRVFCCN YGHCPSTPAT SSTAMPSSTP GTTWILTELT TTATTTESTG STATPSSTPG 

      2470       2480       2490       2500       2510       2520 
TTWILTEPST TATVTVPTGS TATASSTQAT AGTPHVSTTA TTPTVTSSKA TPFSSPGTAT 

      2530       2540       2550       2560       2570       2580 
ALPALRSTAT TPTATSFTAI PSSSLGTTWT RLSQTTTPTA TMSTATPSST PETVHTSTVL 

      2590       2600       2610       2620       2630       2640 
TTTATTTGAT GSVATPSSTP GTAHTTKVLT TTTTGFTATP SSSPGTARTL PVWISTTTTP 

      2650       2660       2670       2680       2690       2700 
TTRGSTVTPS SIPGTTHTPT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT 

      2710       2720       2730       2740       2750       2760 
GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLS 

      2770       2780       2790       2800       2810       2820 
PSSPHTVRTA WTSATSGTLG TTHITEPSTG TSHTPAATTG TTQHSTPALS SPHPSSRTTE 

      2830       2840       2850       2860       2870       2880 
SPPSPGTTTP GHTRATSRTT ATATPSKTRT STLLPSSPTS APITTVVTMG CEPQCAWSEW 

      2890       2900       2910       2920       2930       2940 
LDYSYPMPGP SGGDFDTYSN IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF 

      2950       2960       2970       2980       2990       3000 
GLVCRNREQV GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTEQTTAA 

      3010       3020       3030       3040       3050       3060 
TTTATTGSTA IPSSTPGTAP PPKVLTSTAT TPTATSSKAT SSSSPRTATT LPVLTSTATK 

      3070       3080       3090       3100       3110       3120 
STATSFTPIP SFTLGTTGTL PEQTTTPMAT MSTIHPSSTP ETTHTSTVLT TKATTTRATS 

      3130       3140       3150       3160       3170       3180 
SMSTPSSTPG TTWILTELTT AATTTAATGP TATPSSTPGT TWILTEPSTT ATVTVPTGST 

      3190       3200       3210       3220       3230       3240 
ATASSTRATA GTLKVLTSTA TTPTVISSRA TPSSSPGTAT ALPALRSTAT TPTATSVTAI 

      3250       3260       3270       3280       3290       3300 
PSSSLGTAWT RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTTTTTRAT GSVATPSSTP 

      3310       3320       3330       3340       3350       3360 
GTAHTTKVPT TTTTGFTATP SSSPGTALTP PVWISTTTTP TTRGSTVTPS SIPGTTHTAT 

      3370       3380       3390       3400       3410       3420 
VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP GTTPIPPVLT 

      3430       3440       3450       3460       3470       3480 
TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLP PSSPHTVRTA WTSATSGILG 

      3490       3500       3510       3520       3530       3540 
TTHITEPSTV TSHTPAATTS TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRGTSRTT 

      3550       3560       3570       3580       3590       3600 
ATATPSKTRT STLLPSSPTS APITTVVTTG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN 

      3610       3620       3630       3640       3650       3660 
IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV GKFKMCFNYE 

      3670       3680       3690       3700       3710       3720 
IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTKLTTTA TTTESTGSTA TPSSTPGTTW 

      3730       3740       3750       3760       3770       3780 
ILTEPSTTAT VTVPTGSTAT ASSTQATAGT PHVSTTATTP TVTSSKATPF SSPGTATALP 

      3790       3800       3810       3820       3830       3840 
ALRSTATTPT ATSFTAIPSS SLGTTWTRLS QTTTPTATMS TATPSSTPET AHTSTVLTTT 

      3850       3860       3870       3880       3890       3900 
ATTTRATGSV ATPSSTPGTA HTTKVPTTTT TGFTVTPSSS PGTARTPPVW ISTTTTPTTS 

      3910       3920       3930       3940       3950       3960 
GSTVTPSSVP GTTHTPTVLT TTTTTVATGS MATPSSSTQT SGTPPSLITT ATTITATGST 

      3970       3980       3990       4000       4010       4020 
TNPSSTPGTT PIPPVLTTTA TTPAATSSTV TPSSALGTTH TPPVPNTTAT THGRSLSPSS 

      4030       4040       4050       4060       4070       4080 
PHTVRTAWTS ATSGTLGTTH ITEPSTGTSH TPAATTGTTQ HSTPALSSPH PSSRTTESPP 

      4090       4100       4110       4120       4130       4140 
SPGTTTPGHT TATSRTTATA TPSKTRTSTL LPSSPTSAPI TTVVTTGCEP QCAWSEWLDY 

      4150       4160       4170       4180       4190       4200 
SYPMPGPSGG DFDTYSNIRA AGGAVCEQPL GLECRAQAQP GVPLGELGQV VECSLDFGLV 

      4210       4220       4230       4240       4250       4260 
CRNREQVGKF KMCFNYEIRV FCCNYGHCPS TPATSSTAMP SSTPGTTWIL TELTTTATTT 

      4270       4280       4290       4300       4310       4320 
ASTGSTATPS STPGTAPPPK VLTSPATTPT ATSSKATSSS SPRTATTLPV LTSTATKSTA 

      4330       4340       4350       4360       4370       4380 
TSVTPIPSST LGTTGTLPEQ TTTPVATMST IHPSSTPETT HTSTVLTTKA TTTRATSSTS 

      4390       4400       4410       4420       4430       4440 
TPSSTPGTTW ILTELTTAAT TTAATGPTAT PSSTPGTTWI LTELTTTATT TASTGSTATP 

      4450       4460       4470       4480       4490       4500 
SSTPGTTWIL TEPSTTATVT VPTGSTATAS STQATAGTPH VSTTATTPTV TSSKATPSSS 

      4510       4520       4530       4540       4550       4560 
PGTATALPAL RSTATTPTAT SFTAIPSSSL GTTWTRLSQT TTPTATMSTA TPSSTPETVH 

      4570       4580       4590       4600       4610       4620 
TSTVLTATAT TTGATGSVAT PSSTPGTAHT TKVPTTTTTG FTATPSSSPG TALTPPVWIS 

      4630       4640       4650       4660       4670       4680 
TTTTPTTTTP TTSGSTVTPS SIPGTTHTAR VLTTTTTTVA TGSMATPSSS TQTSGTPPSL 

      4690       4700       4710       4720       4730       4740 
TTTATTITAT GSTTNPSSTP GTTPITPVLT STATTPAATS SKATSSSSPR TATTLPVLTS 

      4750       4760       4770       4780       4790       4800 
TATKSTATSF TPIPSSTLWT TWTVPAQTTT PMSTMSTIHT SSTPETTHTS TVLTTTATMT 

      4810       4820       4830       4840       4850       4860 
RATNSTATPS STLGTTRILT ELTTTATTTA ATGSTATLSS TPGTTWILTE PSTIATVMVP 

      4870       4880       4890       4900       4910       4920 
TGSTATASST LGTAHTPKVV TTMATMPTAT ASTVPSSSTV GTTRTPAVLP SSLPTFSVST 

      4930       4940       4950       4960       4970       4980 
VSSSVLTTLR PTGFPSSHFS TPCFCRAFGQ FFSPGEVIYN KTDRAGCHFY AVCNQHCDID 

      4990       5000       5010       5020       5030       5040 
RFQGACPTSP PPVSSAPLSS PSPAPGCDNA IPLRQVNETW TLENCTVARC VGDNRVVLLD 

      5050       5060       5070       5080       5090       5100 
PKPVANVTCV NKHLPIKVSD PSQPCDFHYE CECICSMWGG SHYSTFDGTS YTFRGNCTYV 

      5110       5120       5130       5140       5150       5160 
LMREIHARFG NLSLYLDNHY CTASATAAAA RCPRALSIHY KSMDIVLTVT MVHGKEEGLI 

      5170       5180       5190       5200       5210       5220 
LFDQIPVSSG FSKNGVLVSV LGTTTMRVDI PALGVSVTFN GQVFQARLPY SLFHNNTEGQ 

      5230       5240       5250       5260       5270       5280 
CGTCTNNQRD DCLQRDGTTA ASCKDMAKTW LVPDSRKDGC WAPTGTPPTA SPAAPVSSTP 

      5290       5300       5310       5320       5330       5340 
TPTPCPPQPL CDLMLSQVFA ECHNLVPPGP FFNACISDHC RGRLEVPCQS LEAYAELCRA 

      5350       5360       5370       5380       5390       5400 
RGVCSDWRGA TGGLCDLTCP PTKVYKPCGP IQPATCNSRN QSPQLEGMAE GCFCPEDQIL 

      5410       5420       5430       5440       5450       5460 
FNAHMGICVQ ACPCVGPDGF PKFPGERWVS NCQSCVCDEG SVSVQCKPLP CDAQGQPPPC 

      5470       5480       5490       5500       5510       5520 
NRPGFVTVTR PRAENPCCPE TVCVCNTTTC PQSLPVCPPG QESICTQEEG DCCPTFRCRP 

      5530       5540       5550       5560       5570       5580 
QLCSYNGTFY GVGATFPGAL PCHMCTCLSG DTQDPTVQCQ EDACNNTTCP QGFEYKRVAG 

      5590       5600       5610       5620       5630       5640 
QCCGECVQTA CLTPDGQPVQ LNETWVNSHV DNCTVYLCEA EGGVHLLTPQ PASCPDVSSC 

      5650       5660       5670       5680       5690       5700 
RGSLRKTGCC YSCEEDSCQV RINTTILWHQ GCETEVNITF CEGSCPGASK YSAEAQAMQH 

      5710       5720       5730       5740       5750       5760 
QCTCCQERRV HEETVPLHCP NGSAILHTYT HVDECGCTPF CVPAPMAPPH TRGFPAQEAT 


AV 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region."
Chen Y., Zhao Y.H., Di Y.P., Wu R.
Am. J. Respir. Cell Mol. Biol. 25:542-553(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1593, INDUCTION, TISSUE SPECIFICITY, VARIANT GLY-34.
[2]"The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions."
Offner G.D., Nunes D.P., Keates A.C., Afdhal N.H., Troxler R.F.
Biochem. Biophys. Res. Commun. 251:350-355(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1324.
[3]"Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon."
Desseyn J.-L., Buisine M.P., Porchet N., Aubert J.-P., Laine A.
J. Biol. Chem. 273:30157-30164(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-1323, VARIANT GLY-34.
[4]"Human mucin gene MUC5B, the 10.7 kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family."
Desseyn J.-L., Guyonnet-Duperat V., Porchet N., Aubert J.-P., Laine A.
J. Biol. Chem. 272:3168-3178(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1325-4954, NUCLEOTIDE SEQUENCE [MRNA] OF 4170-4791, VARIANTS SER-1805; LEU-1889; THR-2025; THR-2194; PRO-2238; THR-2425; SER-3072; ALA-3284; PRO-3468; MET-3816; GLY-4404; LEU-4440; PRO-4706; MET-4712; THR-4867 AND ALA-4882.
Tissue: Placenta and Tracheobronchial mucosa.
[5]"Proteolytic fragmentation and peptide mapping of human carboxyamidomethylated tracheobronchial mucin."
Rose M.C., Kaufman B., Martin B.M.
J. Biol. Chem. 264:8193-8199(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2346-2358; 2903-2915; 3603-3615 AND 4160-4172.
Tissue: Tracheobronchial mucosa.
[6]"Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B."
Nielsen P.A., Bennett E.P., Wandall H.H., Therkildsen M.H., Hannibal J., Clausen H.
Glycobiology 7:413-419(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2301-3811, TISSUE SPECIFICITY.
Tissue: Salivary gland.
[7]"Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B."
Keates A.C., Nunes D.P., Afdhal N.H., Troxler R.F., Offner G.D.
Biochem. J. 324:295-303(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4780-5423, NUCLEOTIDE SEQUENCE [MRNA] OF 5373-5762, TISSUE SPECIFICITY.
Tissue: Gall bladder.
[8]"Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland."
Troxler R.F., Offner G.D., Zhang F., Iontcheva I., Oppenheim F.G.
Biochem. Biophys. Res. Commun. 217:1112-1119(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4868-5746, TISSUE SPECIFICITY.
Tissue: Sublingual gland.
[9]"Genomic organization of the 3 region of the human MUC5B mucin."
Desseyn J.-L., Aubert J.-P., Porchet N., Laine A.
J. Biol. Chem. 272:16873-16883(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4918-5762, VARIANT THR-5196.
Tissue: Placenta.
[10]"In vivo glycosylation of mucin tandem repeats."
Silverman H.S., Parry S., Sutton-Smith M., Burdick M.D., McDermott K., Reid C.J., Batra S.K., Morris H.R., Hollingsworth M.A., Dell A., Harris A.
Glycobiology 11:459-471(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE OF O-LINKED CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
[11]"C-Mannosylation of MUC5AC and MUC5B Cys subdomains."
Perez-Vilar J., Randell S.H., Boucher R.C.
Glycobiology 14:325-337(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION, MUTAGENESIS OF TRP-1790.
[12]"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145; ASN-254; ASN-1556; ASN-4960; ASN-5017; ASN-5024; ASN-5046; ASN-5096; ASN-5111 AND ASN-5215.
Tissue: Saliva.
[13]"A common MUC5B promoter polymorphism and pulmonary fibrosis."
Seibold M.A., Wise A.L., Speer M.C., Steele M.P., Brown K.K., Loyd J.E., Fingerlin T.E., Zhang W., Gudmundsson G., Groshong S.D., Evans C.M., Garantziotis S., Adler K.B., Dickey B.F., du Bois R.M., Yang I.V., Herron A., Kervitsky D. expand/collapse author list , Talbert J.L., Markin C., Park J., Crews A.L., Slifer S.H., Auerbach S., Roy M.G., Lin J., Hennessy C.E., Schwarz M.I., Schwartz D.A.
N. Engl. J. Med. 364:1503-1512(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO IPF.
[14]"A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis."
Zhang Y., Noth I., Garcia J.G., Kaminski N.
N. Engl. J. Med. 364:1576-1577(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO IPF.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF107890 Genomic DNA. Translation: AAG33673.1.
AF086604 mRNA. Translation: AAC67545.1.
AJ004862 Genomic DNA. Translation: CAA06167.1. Different initiation.
X74955 mRNA. Translation: CAA52910.1.
Z72496 Genomic DNA. Translation: CAA96577.1.
U63836 mRNA. Translation: AAB61398.1.
U78551 mRNA. Translation: AAC51343.1.
AH006676 Genomic DNA. Translation: AAC51344.1.
U95031 mRNA. Translation: AAB65151.1.
Y09788 Genomic DNA. Translation: CAA70926.1.
CCDSCCDS44515.2.
PIRA33811.
T45025.
RefSeqNP_002449.2. NM_002458.2.
UniGeneHs.523395.

3D structure databases

ProteinModelPortalQ9HC84.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid608337. 4 interactions.

Protein family/group databases

MEROPSI08.953.

PTM databases

PhosphoSiteQ9HC84.

Polymorphism databases

DMDM308153579.

Proteomic databases

MaxQBQ9HC84.
PaxDbQ9HC84.
PRIDEQ9HC84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000529681; ENSP00000436812; ENSG00000117983.
GeneID727897.
KEGGhsa:727897.
UCSCuc001lta.3. human.

Organism-specific databases

CTD727897.
GeneCardsGC11P001244.
H-InvDBHIX0035863.
HIX0171268.
HIX0171346.
HGNCHGNC:7516. MUC5B.
HPACAB009396.
HPA008246.
MIM178500. phenotype.
600770. gene.
neXtProtNX_Q9HC84.
Orphanet171700. Diffuse panbronchiolitis.
2032. Idiopathic pulmonary fibrosis.
PharmGKBPA31321.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOVERGENHBG052535.
InParanoidQ9HC84.
KOK13908.
TreeFamTF300299.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressQ9HC84.
BgeeQ9HC84.
GenevestigatorQ9HC84.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view]
PfamPF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 7 hits.
PF01826. TIL. 3 hits.
PF00093. VWC. 1 hit.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTSM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 3 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMSSF57567. SSF57567. 4 hits.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMUC5B. human.
GeneWikiMUC5B.
GenomeRNAi727897.
NextBio125477.
PROQ9HC84.
SOURCESearch...

Entry information

Entry nameMUC5B_HUMAN
AccessionPrimary (citable) accession number: Q9HC84
Secondary accession number(s): O00447 expand/collapse secondary AC list , O00573, O14985, O15494, O95291, O95451, Q14881, Q7M4S5, Q99552, Q9UE28
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM