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Q9HC84

- MUC5B_HUMAN

UniProt

Q9HC84 - MUC5B_HUMAN

Protein

Mucin-5B

Gene

MUC5B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. O-glycan processing Source: Reactome
    3. post-translational protein modification Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Protein family/group databases

    MEROPSiI08.953.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mucin-5B
    Short name:
    MUC-5B
    Alternative name(s):
    Cervical mucin
    High molecular weight salivary mucin MG1
    Mucin-5 subtype B, tracheobronchial
    Sublingual gland mucin
    Gene namesi
    Name:MUC5B
    Synonyms:MUC5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:7516. MUC5B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. Golgi lumen Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease.2 Publications
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741).1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1790 – 17901W → A: Poorly secreted. 1 Publication

    Organism-specific databases

    MIMi178500. phenotype.
    Orphaneti171700. Diffuse panbronchiolitis.
    2032. Idiopathic pulmonary fibrosis.
    PharmGKBiPA31321.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 57625737Mucin-5BPRO_0000019283Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 5741By similarity
    Disulfide bondi99 ↔ 107By similarity
    Glycosylationi145 – 1451N-linked (GlcNAc...)2 Publications
    Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi254 – 2541N-linked (GlcNAc...)2 Publications
    Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi447 ↔ 455By similarity
    Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi805 – 8051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi929 – 9291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1276 – 12761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1292 – 12921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1340 – 13401C-linked (Man)Curated
    Glycosylationi1509 – 15091C-linked (Man)Curated
    Glycosylationi1556 – 15561N-linked (GlcNAc...)2 Publications
    Glycosylationi1774 – 17741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1790 – 17901C-linked (Man)Curated
    Glycosylationi2320 – 23201C-linked (Man)Curated
    Glycosylationi2749 – 27491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2877 – 28771C-linked (Man)Curated
    Glycosylationi3449 – 34491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3577 – 35771C-linked (Man)Curated
    Glycosylationi4006 – 40061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4134 – 41341C-linked (Man)Curated
    Glycosylationi4804 – 48041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4960 – 49601N-linked (GlcNAc...)2 Publications
    Glycosylationi5017 – 50171N-linked (GlcNAc...)2 Publications
    Glycosylationi5024 – 50241N-linked (GlcNAc...)2 Publications
    Glycosylationi5046 – 50461N-linked (GlcNAc...)2 Publications
    Glycosylationi5096 – 50961N-linked (GlcNAc...)2 Publications
    Glycosylationi5111 – 51111N-linked (GlcNAc...)2 Publications
    Glycosylationi5215 – 52151N-linked (GlcNAc...)2 Publications
    Glycosylationi5486 – 54861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5526 – 55261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5565 – 55651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5566 – 55661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5602 – 56021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5612 – 56121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi5653 ↔ 5705By similarity
    Glycosylationi5663 – 56631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi5672 ↔ 5719By similarity
    Glycosylationi5677 – 56771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi5681 ↔ 5735By similarity
    Disulfide bondi5685 ↔ 5737By similarity
    Glycosylationi5721 – 57211N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc2Hex1HexNac1-ol.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9HC84.
    PaxDbiQ9HC84.
    PRIDEiQ9HC84.

    PTM databases

    PhosphoSiteiQ9HC84.

    Expressioni

    Tissue specificityi

    Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas.4 Publications

    Inductioni

    Regulated by all-trans-retinoic acid (ATRA) in a cell-type specific manner.1 Publication

    Gene expression databases

    ArrayExpressiQ9HC84.
    BgeeiQ9HC84.
    GenevestigatoriQ9HC84.

    Organism-specific databases

    HPAiCAB009396.
    HPA008246.

    Interactioni

    Protein-protein interaction databases

    BioGridi608337. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HC84.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini76 – 277202VWFD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini329 – 38557TIL 1Add
    BLAST
    Domaini424 – 638215VWFD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini695 – 75258TIL 2Add
    BLAST
    Domaini805 – 85551TIL 3Add
    BLAST
    Domaini855 – 92773VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini894 – 1099206VWFD 3PROSITE-ProRule annotationAdd
    BLAST
    Repeati1333 – 1432100Cys-rich subdomain 1Add
    BLAST
    Repeati1503 – 1604102Cys-rich subdomain 2Add
    BLAST
    Repeati1784 – 1885102Cys-rich subdomain 3Add
    BLAST
    Repeati2313 – 2414102Cys-rich subdomain 4Add
    BLAST
    Repeati2854 – 288633HAT 1Add
    BLAST
    Repeati2871 – 2971101Cys-rich subdomain 5Add
    BLAST
    Repeati3554 – 358633HAT 2Add
    BLAST
    Repeati3571 – 3671101Cys-rich subdomain 6Add
    BLAST
    Repeati4111 – 414333HAT 3Add
    BLAST
    Repeati4128 – 4228101Cys-rich subdomain 7Add
    BLAST
    Domaini5074 – 5305232VWFD 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini5412 – 548473VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini5521 – 558767VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini5653 – 574290CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1333 – 422828967 X Cys-rich subdomain repeatsAdd
    BLAST
    Regioni1890 – 219931011 X approximate tandem repeats, Ser/Thr-richAdd
    BLAST
    Regioni2419 – 275633811 X approximate tandem repeats, Ser/Thr-richAdd
    BLAST
    Regioni2976 – 345648117 X approximate tandem repeats, Ser/Thr-richAdd
    BLAST
    Regioni3676 – 401333811 X approximate tandem repeats, Ser/Thr-richAdd
    BLAST
    Regioni4233 – 487964723 X approximate tandem repeats, Ser/Thr-richAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1109 – 1261153Cys-richAdd
    BLAST
    Compositional biasi1456 – 150247Thr-richAdd
    BLAST
    Compositional biasi1608 – 49323325Thr-richAdd
    BLAST

    Domaini

    The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.

    Sequence similaritiesi

    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 3 HAT repeats.Curated
    Contains 3 VWFC domains.PROSITE-ProRule annotation
    Contains 4 VWFD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOVERGENiHBG052535.
    InParanoidiQ9HC84.
    KOiK13908.
    TreeFamiTF300299.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR006552. VWC_out.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    IPR025155. WxxW_domain.
    [Graphical view]
    PfamiPF08742. C8. 4 hits.
    PF13330. Mucin2_WxxW. 7 hits.
    PF01826. TIL. 3 hits.
    PF00093. VWC. 1 hit.
    PF00094. VWD. 4 hits.
    [Graphical view]
    SMARTiSM00832. C8. 4 hits.
    SM00041. CT. 1 hit.
    SM00214. VWC. 3 hits.
    SM00215. VWC_out. 1 hit.
    SM00216. VWD. 4 hits.
    [Graphical view]
    SUPFAMiSSF57567. SSF57567. 4 hits.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9HC84-1 [UniParc]FASTAAdd to Basket

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    MGAPSACRTL VLALAAMLVV PQAETQGPVE PSWENAGHTM DGGAPTSSPT     50
    RRVSFVPPVT VFPSLSPLNP AHNGRVCSTW GDFHYKTFDG DVFRFPGLCN 100
    YVFSEHCRAA YEDFNVQLRR GLVGSRPVVT RVVIKAQGLV LEASNGSVLI 150
    NGQREELPYS RTGLLVEQSG DYIKVSIRLV LTFLWNGEDS ALLELDPKYA 200
    NQTCGLCGDF NGLPAFNEFY AHNARLTPLQ FGNLQKLDGP TEQCPDPLPL 250
    PAGNCTDEEG ICHRTLLGPA FAECHALVDS TAYLAACAQD LCRCPTCPCA 300
    TFVEYSRQCA HAGGQPRNWR CPELCPRTCP LNMQHQECGS PCTDTCSNPQ 350
    RAQLCEDHCV DGCFCPPGTV LDDITHSGCL PLGQCPCTHG GRTYSPGTSF 400
    NTTCSSCTCS GGLWQCQDLP CPGTCSVQGG AHISTYDEKL YDLHGDCSYV 450
    LSKKCADSSF TVLAELRKCG LTDNENCLKA VTLSLDGGDT AIRVQADGGV 500
    FLNSIYTQLP LSAANITLFT PSSFFIVVQT GLGLQLLVQL VPLMQVFVRL 550
    DPAHQGQMCG LCGNFNQNQA DDFTALSGVV EATGAAFANT WKAQAACANA 600
    RNSFEDPCSL SVENENYARH WCSRLTDPNS AFSRCHSIIN PKPFHSNCMF 650
    DTCNCERSED CLCAALSSYV HACAAKGVQL SDWRDGVCTK YMQNCPKSQR 700
    YAYVVDACQP TCRGLSEADV TCSVSFVPVD GCTCPAGTFL NDAGACVPAQ 750
    ECPCYAHGTV LAPGEVVHDE GAVCSCTGGK LSCLGASLQK STGCAAPMVY 800
    LDCSNSSAGT PGAECLRSCH TLDVGCFSTH CVSGCVCPPG LVSDGSGGCI 850
    AEEDCPCVHN EATYKPGETI RVDCNTCTCR NRRWECSHRL CLGTCVAYGD 900
    GHFITFDGDR YSFEGSCEYI LAQDYCGDNT THGTFRIVTE NIPCGTTGTT 950
    CSKAIKLFVE SYELILQEGT FKAVARGPGG DPPYKIRYMG IFLVIETHGM 1000
    AVSWDRKTSV FIRLHQDYKG RVCGLCGNFD DNAINDFATR SRSVVGDALE 1050
    FGNSWKLSPS CPDALAPKDP CTANPFRKSW AQKQCSILHG PTFAACRSQV 1100
    DSTKYYEACV NDACACDSGG DCECFCTAVA AYAQACHDAG LCVSWRTPDT 1150
    CPLFCDFYNP HGGCEWHYQP CGAPCLKTCR NPSGHCLVDL PGLEGCYPKC 1200
    PPSQPFFNED QMKCVAQCGC YDKDGNYYDV GARVPTAENC QSCNCTPSGI 1250
    QCAHSLEACT CTYEDRTYSY QDVIYNTTDG LGACLIAICG SNGTIIRKAV 1300
    ACPGTPATTP FTFTTAWVPH STTSPALPVS TVCVREVCRW SSWYNGHRPE 1350
    PGLGGGDFET FENLRQRGYQ VCPVLADIEC RAAQLPDMPL EELGQQVDCD 1400
    RMRGLMCANS QQSPPLCHDY ELRVLCCEYV PCGPSPAPGT SPQPSLSAST 1450
    EPAVPTPTQT TATEKTTLWV TPSIRSTAAL TSQTGSSSGP VTVTPSAPGT 1500
    TTCQPRCQWT EWFDEDYPKS EQLGGDVESY DKIRAAGGHL CQQPKDIECQ 1550
    AESFPNWTLA QVGQKVHCDV HFGLVCRNWE QEGVFKMCYN YRIRVLCCSD 1600
    DHCRGRATTP PPTTELETAT TTTTQALFST PQPTSSPGLT RAPPASTTAV 1650
    PTLSEGLTSP RYTSTLGTAT TGGPTTPAGS TEPTVPGVAT STLPTRSALP 1700
    GTTGSLGTWR PSQPPTLAPT TMATSRARPT GTASTASKEP LTTSLAPTLT 1750
    SELSTSQAET STPRTETTMS PLTNTTTSQG TTRCQPKCEW TEWFDVDFPT 1800
    SGVAGGDMET FENIRAAGGK MCWAPKSIEC RAENYPEVSI DQVGQVLTCS 1850
    LETGLTCKNE DQTGRFNMCF NYNVRVLCCD DYSHCPSTPA TSSTATPSST 1900
    PGTTWILTKP TTTATTTAST GSTATPTSTL RTAPPPKVLT TTATTPTVTS 1950
    SKATPSSSPG TATALPALRS TATTPTATSV TPIPSSSLGT TWTRLSQTTT 2000
    PTATMSTATP SSTPETAHTS TVLTATATTT GATGSVATPS STPGTAHTTK 2050
    VPTTTTTGFT ATPSSSPGTA LTPPVWISTT TTPTTRGSTV TPSSIPGTTH 2100
    TATVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI TATGSTTNPS 2150
    STPGTTPIPP VLTTTATTPA ATSNTVTPSS ALGTTHTPPV PNTMATTHGR 2200
    SLPPSSPHTV RTAWTSATSG ILGTTHITEP STVTSHTLAA TTGTTQHSTP 2250
    ALSSPHPSSR TTESPPSPGT TTPGHTTATS RTTATATPSK TRTSTLLPSS 2300
    PTSAPITTVV TMGCEPQCAW SEWLDYSYPM PGPSGGDFDT YSNIRAAGGA 2350
    VCEQPLGLEC RAQAQPGVPL RELGQVVECS LDFGLVCRNR EQVGKFKMCF 2400
    NYEIRVFCCN YGHCPSTPAT SSTAMPSSTP GTTWILTELT TTATTTESTG 2450
    STATPSSTPG TTWILTEPST TATVTVPTGS TATASSTQAT AGTPHVSTTA 2500
    TTPTVTSSKA TPFSSPGTAT ALPALRSTAT TPTATSFTAI PSSSLGTTWT 2550
    RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTATTTGAT GSVATPSSTP 2600
    GTAHTTKVLT TTTTGFTATP SSSPGTARTL PVWISTTTTP TTRGSTVTPS 2650
    SIPGTTHTPT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT 2700
    GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT 2750
    TATTHGRSLS PSSPHTVRTA WTSATSGTLG TTHITEPSTG TSHTPAATTG 2800
    TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRATSRTT ATATPSKTRT 2850
    STLLPSSPTS APITTVVTMG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN 2900
    IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV 2950
    GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTEQTTAA 3000
    TTTATTGSTA IPSSTPGTAP PPKVLTSTAT TPTATSSKAT SSSSPRTATT 3050
    LPVLTSTATK STATSFTPIP SFTLGTTGTL PEQTTTPMAT MSTIHPSSTP 3100
    ETTHTSTVLT TKATTTRATS SMSTPSSTPG TTWILTELTT AATTTAATGP 3150
    TATPSSTPGT TWILTEPSTT ATVTVPTGST ATASSTRATA GTLKVLTSTA 3200
    TTPTVISSRA TPSSSPGTAT ALPALRSTAT TPTATSVTAI PSSSLGTAWT 3250
    RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTTTTTRAT GSVATPSSTP 3300
    GTAHTTKVPT TTTTGFTATP SSSPGTALTP PVWISTTTTP TTRGSTVTPS 3350
    SIPGTTHTAT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT 3400
    GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT 3450
    TATTHGRSLP PSSPHTVRTA WTSATSGILG TTHITEPSTV TSHTPAATTS 3500
    TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRGTSRTT ATATPSKTRT 3550
    STLLPSSPTS APITTVVTTG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN 3600
    IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV 3650
    GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTKLTTTA 3700
    TTTESTGSTA TPSSTPGTTW ILTEPSTTAT VTVPTGSTAT ASSTQATAGT 3750
    PHVSTTATTP TVTSSKATPF SSPGTATALP ALRSTATTPT ATSFTAIPSS 3800
    SLGTTWTRLS QTTTPTATMS TATPSSTPET AHTSTVLTTT ATTTRATGSV 3850
    ATPSSTPGTA HTTKVPTTTT TGFTVTPSSS PGTARTPPVW ISTTTTPTTS 3900
    GSTVTPSSVP GTTHTPTVLT TTTTTVATGS MATPSSSTQT SGTPPSLITT 3950
    ATTITATGST TNPSSTPGTT PIPPVLTTTA TTPAATSSTV TPSSALGTTH 4000
    TPPVPNTTAT THGRSLSPSS PHTVRTAWTS ATSGTLGTTH ITEPSTGTSH 4050
    TPAATTGTTQ HSTPALSSPH PSSRTTESPP SPGTTTPGHT TATSRTTATA 4100
    TPSKTRTSTL LPSSPTSAPI TTVVTTGCEP QCAWSEWLDY SYPMPGPSGG 4150
    DFDTYSNIRA AGGAVCEQPL GLECRAQAQP GVPLGELGQV VECSLDFGLV 4200
    CRNREQVGKF KMCFNYEIRV FCCNYGHCPS TPATSSTAMP SSTPGTTWIL 4250
    TELTTTATTT ASTGSTATPS STPGTAPPPK VLTSPATTPT ATSSKATSSS 4300
    SPRTATTLPV LTSTATKSTA TSVTPIPSST LGTTGTLPEQ TTTPVATMST 4350
    IHPSSTPETT HTSTVLTTKA TTTRATSSTS TPSSTPGTTW ILTELTTAAT 4400
    TTAATGPTAT PSSTPGTTWI LTELTTTATT TASTGSTATP SSTPGTTWIL 4450
    TEPSTTATVT VPTGSTATAS STQATAGTPH VSTTATTPTV TSSKATPSSS 4500
    PGTATALPAL RSTATTPTAT SFTAIPSSSL GTTWTRLSQT TTPTATMSTA 4550
    TPSSTPETVH TSTVLTATAT TTGATGSVAT PSSTPGTAHT TKVPTTTTTG 4600
    FTATPSSSPG TALTPPVWIS TTTTPTTTTP TTSGSTVTPS SIPGTTHTAR 4650
    VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP 4700
    GTTPITPVLT STATTPAATS SKATSSSSPR TATTLPVLTS TATKSTATSF 4750
    TPIPSSTLWT TWTVPAQTTT PMSTMSTIHT SSTPETTHTS TVLTTTATMT 4800
    RATNSTATPS STLGTTRILT ELTTTATTTA ATGSTATLSS TPGTTWILTE 4850
    PSTIATVMVP TGSTATASST LGTAHTPKVV TTMATMPTAT ASTVPSSSTV 4900
    GTTRTPAVLP SSLPTFSVST VSSSVLTTLR PTGFPSSHFS TPCFCRAFGQ 4950
    FFSPGEVIYN KTDRAGCHFY AVCNQHCDID RFQGACPTSP PPVSSAPLSS 5000
    PSPAPGCDNA IPLRQVNETW TLENCTVARC VGDNRVVLLD PKPVANVTCV 5050
    NKHLPIKVSD PSQPCDFHYE CECICSMWGG SHYSTFDGTS YTFRGNCTYV 5100
    LMREIHARFG NLSLYLDNHY CTASATAAAA RCPRALSIHY KSMDIVLTVT 5150
    MVHGKEEGLI LFDQIPVSSG FSKNGVLVSV LGTTTMRVDI PALGVSVTFN 5200
    GQVFQARLPY SLFHNNTEGQ CGTCTNNQRD DCLQRDGTTA ASCKDMAKTW 5250
    LVPDSRKDGC WAPTGTPPTA SPAAPVSSTP TPTPCPPQPL CDLMLSQVFA 5300
    ECHNLVPPGP FFNACISDHC RGRLEVPCQS LEAYAELCRA RGVCSDWRGA 5350
    TGGLCDLTCP PTKVYKPCGP IQPATCNSRN QSPQLEGMAE GCFCPEDQIL 5400
    FNAHMGICVQ ACPCVGPDGF PKFPGERWVS NCQSCVCDEG SVSVQCKPLP 5450
    CDAQGQPPPC NRPGFVTVTR PRAENPCCPE TVCVCNTTTC PQSLPVCPPG 5500
    QESICTQEEG DCCPTFRCRP QLCSYNGTFY GVGATFPGAL PCHMCTCLSG 5550
    DTQDPTVQCQ EDACNNTTCP QGFEYKRVAG QCCGECVQTA CLTPDGQPVQ 5600
    LNETWVNSHV DNCTVYLCEA EGGVHLLTPQ PASCPDVSSC RGSLRKTGCC 5650
    YSCEEDSCQV RINTTILWHQ GCETEVNITF CEGSCPGASK YSAEAQAMQH 5700
    QCTCCQERRV HEETVPLHCP NGSAILHTYT HVDECGCTPF CVPAPMAPPH 5750
    TRGFPAQEAT AV 5762
    Length:5,762
    Mass (Da):596,340
    Last modified:October 5, 2010 - v3
    Checksum:i1FEC7CDCD0ADA81C
    GO

    Sequence cautioni

    The sequence CAA06167.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 1006FPGLCN → LPCLCK in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti104 – 1041S → C in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti142 – 1421E → K in AAG33673. (PubMed:11713095)Curated
    Sequence conflicti225 – 2251R → S in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti330 – 3312PL → T in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti337 – 3371E → N in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti356 – 3561E → K in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti362 – 3621G → R in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti368 – 3681G → GS in AAG33673. (PubMed:11713095)Curated
    Sequence conflicti373 – 3731D → N in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti392 – 3932RT → TR in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti467 – 4682RK → GR in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti511 – 5111L → P in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti584 – 5863GAA → AH in CAA06167. (PubMed:9804771)Curated
    Sequence conflicti600 – 6001A → S in CAA06167. (PubMed:9804771)Curated
    Sequence conflicti627 – 6282DP → RS in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti632 – 6321F → L in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti675 – 6751A → P in CAA06167. (PubMed:9804771)Curated
    Sequence conflicti700 – 7001R → P in CAA06167. (PubMed:9804771)Curated
    Sequence conflicti751 – 7511E → K in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti811 – 8111P → L in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti816 – 8172LR → DG in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti859 – 8602HN → NK in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti866 – 8661P → L in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti872 – 8721V → F in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti883 – 8831R → T in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti889 – 8891R → G in CAA06167. (PubMed:9804771)Curated
    Sequence conflicti1020 – 10201G → A in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti1082 – 10821Q → E in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti1144 – 11441S → C in CAA06167. (PubMed:9804771)Curated
    Sequence conflicti1195 – 11951G → R in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti1207 – 12071Missing in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti1291 – 12911S → T in CAA06167. (PubMed:9804771)Curated
    Sequence conflicti1317 – 13171Missing in AAC67545. (PubMed:9790959)Curated
    Sequence conflicti1675 – 16773TTP → RQS in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti1926 – 19272PT → AS in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti1930 – 19312LR → QA in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti1934 – 19407PPPKVLT → GTPHVS in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti1956 – 19561S → F in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti1980 – 19823VTP → FTA in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2002 – 20021T → M in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2017 – 20171A → V in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2052 – 20521P → L in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2069 – 20735TALTP → RARTL in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2102 – 21021A → P in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2174 – 21741N → S in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2203 – 22031P → S in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2211 – 22111R → C in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2233 – 22331V → G in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2300 – 23001S → Q in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2333 – 23331P → S in AAB61398. (PubMed:9147051)Curated
    Sequence conflicti2456 – 249742SSTPG…TPHVS → TSTLRTAPPPKVLT in CAA96577. (PubMed:9013550)CuratedAdd
    BLAST
    Sequence conflicti2461 – 24622TT → DD in AAB61398. (PubMed:9147051)Curated
    Sequence conflicti2468 – 36951228Missing in AAB61398. (PubMed:9147051)CuratedAdd
    BLAST
    Sequence conflicti2513 – 25131F → S in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2537 – 25393FTA → VTP in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2574 – 25741V → A in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2582 – 25821T → A in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2609 – 26091L → P in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2628 – 26303RTL → LTP in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2659 – 26591P → A in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2713 – 27131T → R in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti2834 – 28341R → T in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti3028 – 30281T → Q in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti3080 – 30867LPEQTTT → SQNRPPH in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti3148 – 31525TGPTA → LPHG in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti3289 – 32891Missing in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti3490 – 34901V → G in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti3500 – 35001S → G in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti3504 – 35041H → P in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti3716 – 374732PGTTW…STQAT → QGPP in CAA96577. (PubMed:9013550)CuratedAdd
    BLAST
    Sequence conflicti3811 – 38111Q → P in AAB61398. (PubMed:9147051)Curated
    Sequence conflicti3831 – 38311A → V in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti3845 – 38451R → G in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti3909 – 39091V → I in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti3924 – 39252TT → QP in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti3975 – 39751V → E in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti4060 – 40612QH → TT in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti4114 – 41141S → Q in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti4177 – 41771Q → T in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti4313 – 43131S → T in CAA52910. (PubMed:9013550)Curated
    Sequence conflicti4373 – 43731Missing in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti4461 – 44633VPT → APP in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti4567 – 45671A → T in CAA96577. (PubMed:9013550)Curated
    Sequence conflicti4780 – 47801T → P in AAC51344. (PubMed:9164870)Curated
    Sequence conflicti5134 – 51341R → A in AAB65151. (PubMed:8554565)Curated
    Sequence conflicti5164 – 51641Q → P in AAB65151. (PubMed:8554565)Curated
    Sequence conflicti5187 – 51871R → A in AAC51344. (PubMed:9164870)Curated
    Sequence conflicti5187 – 51871R → A in AAB65151. (PubMed:8554565)Curated
    Sequence conflicti5289 – 52891P → L in AAB65151. (PubMed:8554565)Curated
    Sequence conflicti5304 – 53063NLV → TLL in AAB65151. (PubMed:8554565)Curated
    Sequence conflicti5333 – 53331A → R in AAC51344. (PubMed:9164870)Curated
    Sequence conflicti5397 – 53971D → N in AAC51343. (PubMed:9164870)Curated
    Sequence conflicti5397 – 53971D → N in AAC51344. (PubMed:9164870)Curated
    Sequence conflicti5474 – 54741E → R in CAA70926. (PubMed:9201995)Curated
    Sequence conflicti5475 – 54751N → T in AAB65151. (PubMed:8554565)Curated
    Sequence conflicti5620 – 56201A → S in AAB65151. (PubMed:8554565)Curated
    Sequence conflicti5632 – 56321A → D in AAC51343. (PubMed:9164870)Curated
    Sequence conflicti5660 – 56601V → C in AAB65151. (PubMed:8554565)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti34 – 341E → G.2 Publications
    Corresponds to variant rs2672785 [ dbSNP | Ensembl ].
    VAR_063616
    Natural varianti51 – 511R → W.
    Corresponds to variant rs2075853 [ dbSNP | Ensembl ].
    VAR_056588
    Natural varianti1360 – 13601T → M.
    Corresponds to variant rs12363494 [ dbSNP | Ensembl ].
    VAR_059538
    Natural varianti1401 – 14011R → H.
    Corresponds to variant rs10835639 [ dbSNP | Ensembl ].
    VAR_059539
    Natural varianti1805 – 18051G → S.1 Publication
    Corresponds to variant rs1541314 [ dbSNP | Ensembl ].
    VAR_063617
    Natural varianti1889 – 18891P → L.1 Publication
    Corresponds to variant rs2943510 [ dbSNP | Ensembl ].
    VAR_063618
    Natural varianti2025 – 20251A → T.1 Publication
    Corresponds to variant rs34739266 [ dbSNP | Ensembl ].
    VAR_063619
    Natural varianti2027 – 20271A → T.
    Corresponds to variant rs2943531 [ dbSNP | Ensembl ].
    VAR_059540
    Natural varianti2194 – 21941M → T.1 Publication
    Corresponds to variant rs2943502 [ dbSNP | Ensembl ].
    VAR_063620
    Natural varianti2238 – 22381L → P.1 Publication
    Corresponds to variant rs4963031 [ dbSNP | Ensembl ].
    VAR_063621
    Natural varianti2425 – 24251M → T.1 Publication
    Corresponds to variant rs3965632 [ dbSNP | Ensembl ].
    VAR_063622
    Natural varianti2559 – 25591T → M.
    Corresponds to variant rs2860722 [ dbSNP | Ensembl ].
    VAR_059541
    Natural varianti3072 – 30721F → S.1 Publication
    Corresponds to variant rs3021161 [ dbSNP | Ensembl ].
    VAR_063623
    Natural varianti3284 – 32841T → A.1 Publication
    Corresponds to variant rs2943531 [ dbSNP | Ensembl ].
    VAR_063624
    Natural varianti3468 – 34681R → P.1 Publication
    Corresponds to variant rs2943529 [ dbSNP | Ensembl ].
    VAR_063625
    Natural varianti3816 – 38161T → M.1 Publication
    Corresponds to variant rs75917341 [ dbSNP | Ensembl ].
    VAR_063626
    Natural varianti4404 – 44041A → G.1 Publication
    Corresponds to variant rs2943517 [ dbSNP | Ensembl ].
    VAR_063627
    Natural varianti4440 – 44401P → L.1 Publication
    Corresponds to variant rs2943516 [ dbSNP | Ensembl ].
    VAR_063628
    Natural varianti4706 – 47061T → P.1 Publication
    Corresponds to variant rs2943512 [ dbSNP | Ensembl ].
    VAR_063629
    Natural varianti4712 – 47121T → M.1 Publication
    Corresponds to variant rs2943511 [ dbSNP | Ensembl ].
    VAR_063630
    Natural varianti4867 – 48671A → T.1 Publication
    Corresponds to variant rs3021155 [ dbSNP | Ensembl ].
    VAR_063631
    Natural varianti4882 – 48821T → A.1 Publication
    Corresponds to variant rs3021156 [ dbSNP | Ensembl ].
    VAR_063632
    Natural varianti5196 – 51961S → T.1 Publication
    Corresponds to variant rs2672788 [ dbSNP | Ensembl ].
    VAR_014123

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF107890 Genomic DNA. Translation: AAG33673.1.
    AF086604 mRNA. Translation: AAC67545.1.
    AJ004862 Genomic DNA. Translation: CAA06167.1. Different initiation.
    X74955 mRNA. Translation: CAA52910.1.
    Z72496 Genomic DNA. Translation: CAA96577.1.
    U63836 mRNA. Translation: AAB61398.1.
    U78551 mRNA. Translation: AAC51343.1.
    AH006676 Genomic DNA. Translation: AAC51344.1.
    U95031 mRNA. Translation: AAB65151.1.
    Y09788 Genomic DNA. Translation: CAA70926.1.
    CCDSiCCDS44515.2.
    PIRiA33811.
    T45025.
    RefSeqiNP_002449.2. NM_002458.2.
    UniGeneiHs.523395.

    Genome annotation databases

    EnsembliENST00000529681; ENSP00000436812; ENSG00000117983.
    GeneIDi727897.
    KEGGihsa:727897.
    UCSCiuc001lta.3. human.

    Polymorphism databases

    DMDMi308153579.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Mucin database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF107890 Genomic DNA. Translation: AAG33673.1 .
    AF086604 mRNA. Translation: AAC67545.1 .
    AJ004862 Genomic DNA. Translation: CAA06167.1 . Different initiation.
    X74955 mRNA. Translation: CAA52910.1 .
    Z72496 Genomic DNA. Translation: CAA96577.1 .
    U63836 mRNA. Translation: AAB61398.1 .
    U78551 mRNA. Translation: AAC51343.1 .
    AH006676 Genomic DNA. Translation: AAC51344.1 .
    U95031 mRNA. Translation: AAB65151.1 .
    Y09788 Genomic DNA. Translation: CAA70926.1 .
    CCDSi CCDS44515.2.
    PIRi A33811.
    T45025.
    RefSeqi NP_002449.2. NM_002458.2.
    UniGenei Hs.523395.

    3D structure databases

    ProteinModelPortali Q9HC84.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 608337. 4 interactions.

    Protein family/group databases

    MEROPSi I08.953.

    PTM databases

    PhosphoSitei Q9HC84.

    Polymorphism databases

    DMDMi 308153579.

    Proteomic databases

    MaxQBi Q9HC84.
    PaxDbi Q9HC84.
    PRIDEi Q9HC84.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000529681 ; ENSP00000436812 ; ENSG00000117983 .
    GeneIDi 727897.
    KEGGi hsa:727897.
    UCSCi uc001lta.3. human.

    Organism-specific databases

    CTDi 727897.
    GeneCardsi GC11P001244.
    H-InvDB HIX0035863.
    HIX0171268.
    HIX0171346.
    HGNCi HGNC:7516. MUC5B.
    HPAi CAB009396.
    HPA008246.
    MIMi 178500. phenotype.
    600770. gene.
    neXtProti NX_Q9HC84.
    Orphaneti 171700. Diffuse panbronchiolitis.
    2032. Idiopathic pulmonary fibrosis.
    PharmGKBi PA31321.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOVERGENi HBG052535.
    InParanoidi Q9HC84.
    KOi K13908.
    TreeFami TF300299.

    Enzyme and pathway databases

    Reactomei REACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Miscellaneous databases

    ChiTaRSi MUC5B. human.
    GeneWikii MUC5B.
    GenomeRNAii 727897.
    NextBioi 125477.
    PROi Q9HC84.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HC84.
    Bgeei Q9HC84.
    Genevestigatori Q9HC84.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR006552. VWC_out.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    IPR025155. WxxW_domain.
    [Graphical view ]
    Pfami PF08742. C8. 4 hits.
    PF13330. Mucin2_WxxW. 7 hits.
    PF01826. TIL. 3 hits.
    PF00093. VWC. 1 hit.
    PF00094. VWD. 4 hits.
    [Graphical view ]
    SMARTi SM00832. C8. 4 hits.
    SM00041. CT. 1 hit.
    SM00214. VWC. 3 hits.
    SM00215. VWC_out. 1 hit.
    SM00216. VWD. 4 hits.
    [Graphical view ]
    SUPFAMi SSF57567. SSF57567. 4 hits.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region."
      Chen Y., Zhao Y.H., Di Y.P., Wu R.
      Am. J. Respir. Cell Mol. Biol. 25:542-553(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1593, INDUCTION, TISSUE SPECIFICITY, VARIANT GLY-34.
    2. "The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions."
      Offner G.D., Nunes D.P., Keates A.C., Afdhal N.H., Troxler R.F.
      Biochem. Biophys. Res. Commun. 251:350-355(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1324.
    3. "Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon."
      Desseyn J.-L., Buisine M.P., Porchet N., Aubert J.-P., Laine A.
      J. Biol. Chem. 273:30157-30164(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-1323, VARIANT GLY-34.
    4. "Human mucin gene MUC5B, the 10.7 kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family."
      Desseyn J.-L., Guyonnet-Duperat V., Porchet N., Aubert J.-P., Laine A.
      J. Biol. Chem. 272:3168-3178(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1325-4954, NUCLEOTIDE SEQUENCE [MRNA] OF 4170-4791, VARIANTS SER-1805; LEU-1889; THR-2025; THR-2194; PRO-2238; THR-2425; SER-3072; ALA-3284; PRO-3468; MET-3816; GLY-4404; LEU-4440; PRO-4706; MET-4712; THR-4867 AND ALA-4882.
      Tissue: Placenta and Tracheobronchial mucosa.
    5. "Proteolytic fragmentation and peptide mapping of human carboxyamidomethylated tracheobronchial mucin."
      Rose M.C., Kaufman B., Martin B.M.
      J. Biol. Chem. 264:8193-8199(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2346-2358; 2903-2915; 3603-3615 AND 4160-4172.
      Tissue: Tracheobronchial mucosa.
    6. "Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B."
      Nielsen P.A., Bennett E.P., Wandall H.H., Therkildsen M.H., Hannibal J., Clausen H.
      Glycobiology 7:413-419(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2301-3811, TISSUE SPECIFICITY.
      Tissue: Salivary gland.
    7. "Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B."
      Keates A.C., Nunes D.P., Afdhal N.H., Troxler R.F., Offner G.D.
      Biochem. J. 324:295-303(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4780-5423, NUCLEOTIDE SEQUENCE [MRNA] OF 5373-5762, TISSUE SPECIFICITY.
      Tissue: Gall bladder.
    8. "Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland."
      Troxler R.F., Offner G.D., Zhang F., Iontcheva I., Oppenheim F.G.
      Biochem. Biophys. Res. Commun. 217:1112-1119(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4868-5746, TISSUE SPECIFICITY.
      Tissue: Sublingual gland.
    9. "Genomic organization of the 3 region of the human MUC5B mucin."
      Desseyn J.-L., Aubert J.-P., Porchet N., Laine A.
      J. Biol. Chem. 272:16873-16883(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4918-5762, VARIANT THR-5196.
      Tissue: Placenta.
    10. Cited for: STRUCTURE OF O-LINKED CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
    11. "C-Mannosylation of MUC5AC and MUC5B Cys subdomains."
      Perez-Vilar J., Randell S.H., Boucher R.C.
      Glycobiology 14:325-337(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION, MUTAGENESIS OF TRP-1790.
    12. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
      Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
      J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145; ASN-254; ASN-1556; ASN-4960; ASN-5017; ASN-5024; ASN-5046; ASN-5096; ASN-5111 AND ASN-5215.
      Tissue: Saliva.
    13. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO IPF.
    14. "A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis."
      Zhang Y., Noth I., Garcia J.G., Kaminski N.
      N. Engl. J. Med. 364:1576-1577(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO IPF.

    Entry informationi

    Entry nameiMUC5B_HUMAN
    AccessioniPrimary (citable) accession number: Q9HC84
    Secondary accession number(s): O00447
    , O00573, O14985, O15494, O95291, O95451, Q14881, Q7M4S5, Q99552, Q9UE28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3