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Q9HC84

- MUC5B_HUMAN

UniProt

Q9HC84 - MUC5B_HUMAN

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Protein
Mucin-5B
Gene
MUC5B, MUC5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. O-glycan processing Source: Reactome
  2. cellular protein metabolic process Source: Reactome
  3. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Protein family/group databases

MEROPSiI08.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-5B
Short name:
MUC-5B
Alternative name(s):
Cervical mucin
High molecular weight salivary mucin MG1
Mucin-5 subtype B, tracheobronchial
Sublingual gland mucin
Gene namesi
Name:MUC5B
Synonyms:MUC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:7516. MUC5B.

Subcellular locationi

GO - Cellular componenti

  1. Golgi lumen Source: Reactome
  2. extracellular space Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (1 Publication).2 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1790 – 17901W → A: Poorly secreted. 1 Publication

Organism-specific databases

MIMi178500. phenotype.
Orphaneti171700. Diffuse panbronchiolitis.
2032. Idiopathic pulmonary fibrosis.
PharmGKBiPA31321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 57625737Mucin-5B
PRO_0000019283Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 5741 By similarity
Disulfide bondi99 ↔ 107 By similarity
Glycosylationi145 – 1451N-linked (GlcNAc...)1 Publication
Glycosylationi201 – 2011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi254 – 2541N-linked (GlcNAc...)1 Publication
Glycosylationi401 – 4011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi447 ↔ 455 By similarity
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi805 – 8051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi929 – 9291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1276 – 12761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1292 – 12921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1340 – 13401C-linked (Man) Inferred
Glycosylationi1509 – 15091C-linked (Man) Inferred
Glycosylationi1556 – 15561N-linked (GlcNAc...)1 Publication
Glycosylationi1774 – 17741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1790 – 17901C-linked (Man) Inferred
Glycosylationi2320 – 23201C-linked (Man) Inferred
Glycosylationi2749 – 27491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2877 – 28771C-linked (Man) Inferred
Glycosylationi3449 – 34491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3577 – 35771C-linked (Man) Inferred
Glycosylationi4006 – 40061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4134 – 41341C-linked (Man) Inferred
Glycosylationi4804 – 48041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4960 – 49601N-linked (GlcNAc...)1 Publication
Glycosylationi5017 – 50171N-linked (GlcNAc...)1 Publication
Glycosylationi5024 – 50241N-linked (GlcNAc...)1 Publication
Glycosylationi5046 – 50461N-linked (GlcNAc...)1 Publication
Glycosylationi5096 – 50961N-linked (GlcNAc...)1 Publication
Glycosylationi5111 – 51111N-linked (GlcNAc...)1 Publication
Glycosylationi5215 – 52151N-linked (GlcNAc...)1 Publication
Glycosylationi5486 – 54861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5526 – 55261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5565 – 55651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5566 – 55661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5602 – 56021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi5612 – 56121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi5653 ↔ 5705 By similarity
Glycosylationi5663 – 56631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi5672 ↔ 5719 By similarity
Glycosylationi5677 – 56771N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi5681 ↔ 5735 By similarity
Disulfide bondi5685 ↔ 5737 By similarity
Glycosylationi5721 – 57211N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc2Hex1HexNac1-ol.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9HC84.
PaxDbiQ9HC84.
PRIDEiQ9HC84.

PTM databases

PhosphoSiteiQ9HC84.

Expressioni

Tissue specificityi

Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas.4 Publications

Inductioni

Regulated by all-trans-retinoic acid (ATRA) in a cell-type specific manner.1 Publication

Gene expression databases

ArrayExpressiQ9HC84.
BgeeiQ9HC84.
GenevestigatoriQ9HC84.

Organism-specific databases

HPAiCAB009396.
HPA008246.

Interactioni

Protein-protein interaction databases

BioGridi608337. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9HC84.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 277202VWFD 1
Add
BLAST
Domaini329 – 38557TIL 1
Add
BLAST
Domaini424 – 638215VWFD 2
Add
BLAST
Domaini695 – 75258TIL 2
Add
BLAST
Domaini805 – 85551TIL 3
Add
BLAST
Domaini855 – 92773VWFC 1
Add
BLAST
Domaini894 – 1099206VWFD 3
Add
BLAST
Repeati1333 – 1432100Cys-rich subdomain 1
Add
BLAST
Repeati1503 – 1604102Cys-rich subdomain 2
Add
BLAST
Repeati1784 – 1885102Cys-rich subdomain 3
Add
BLAST
Repeati2313 – 2414102Cys-rich subdomain 4
Add
BLAST
Repeati2854 – 288633HAT 1
Add
BLAST
Repeati2871 – 2971101Cys-rich subdomain 5
Add
BLAST
Repeati3554 – 358633HAT 2
Add
BLAST
Repeati3571 – 3671101Cys-rich subdomain 6
Add
BLAST
Repeati4111 – 414333HAT 3
Add
BLAST
Repeati4128 – 4228101Cys-rich subdomain 7
Add
BLAST
Domaini5074 – 5305232VWFD 4
Add
BLAST
Domaini5412 – 548473VWFC 2
Add
BLAST
Domaini5521 – 558767VWFC 3
Add
BLAST
Domaini5653 – 574290CTCK
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1333 – 422828967 X Cys-rich subdomain repeats
Add
BLAST
Regioni1890 – 219931011 X approximate tandem repeats, Ser/Thr-rich
Add
BLAST
Regioni2419 – 275633811 X approximate tandem repeats, Ser/Thr-rich
Add
BLAST
Regioni2976 – 345648117 X approximate tandem repeats, Ser/Thr-rich
Add
BLAST
Regioni3676 – 401333811 X approximate tandem repeats, Ser/Thr-rich
Add
BLAST
Regioni4233 – 487964723 X approximate tandem repeats, Ser/Thr-rich
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1109 – 1261153Cys-rich
Add
BLAST
Compositional biasi1456 – 150247Thr-rich
Add
BLAST
Compositional biasi1608 – 49323325Thr-rich
Add
BLAST

Domaini

The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.

Sequence similaritiesi

Contains 3 HAT repeats.
Contains 3 VWFC domains.
Contains 4 VWFD domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOVERGENiHBG052535.
InParanoidiQ9HC84.
KOiK13908.
TreeFamiTF300299.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view]
PfamiPF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 7 hits.
PF01826. TIL. 3 hits.
PF00093. VWC. 1 hit.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTiSM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 3 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 4 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HC84-1 [UniParc]FASTAAdd to Basket

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MGAPSACRTL VLALAAMLVV PQAETQGPVE PSWENAGHTM DGGAPTSSPT     50
RRVSFVPPVT VFPSLSPLNP AHNGRVCSTW GDFHYKTFDG DVFRFPGLCN 100
YVFSEHCRAA YEDFNVQLRR GLVGSRPVVT RVVIKAQGLV LEASNGSVLI 150
NGQREELPYS RTGLLVEQSG DYIKVSIRLV LTFLWNGEDS ALLELDPKYA 200
NQTCGLCGDF NGLPAFNEFY AHNARLTPLQ FGNLQKLDGP TEQCPDPLPL 250
PAGNCTDEEG ICHRTLLGPA FAECHALVDS TAYLAACAQD LCRCPTCPCA 300
TFVEYSRQCA HAGGQPRNWR CPELCPRTCP LNMQHQECGS PCTDTCSNPQ 350
RAQLCEDHCV DGCFCPPGTV LDDITHSGCL PLGQCPCTHG GRTYSPGTSF 400
NTTCSSCTCS GGLWQCQDLP CPGTCSVQGG AHISTYDEKL YDLHGDCSYV 450
LSKKCADSSF TVLAELRKCG LTDNENCLKA VTLSLDGGDT AIRVQADGGV 500
FLNSIYTQLP LSAANITLFT PSSFFIVVQT GLGLQLLVQL VPLMQVFVRL 550
DPAHQGQMCG LCGNFNQNQA DDFTALSGVV EATGAAFANT WKAQAACANA 600
RNSFEDPCSL SVENENYARH WCSRLTDPNS AFSRCHSIIN PKPFHSNCMF 650
DTCNCERSED CLCAALSSYV HACAAKGVQL SDWRDGVCTK YMQNCPKSQR 700
YAYVVDACQP TCRGLSEADV TCSVSFVPVD GCTCPAGTFL NDAGACVPAQ 750
ECPCYAHGTV LAPGEVVHDE GAVCSCTGGK LSCLGASLQK STGCAAPMVY 800
LDCSNSSAGT PGAECLRSCH TLDVGCFSTH CVSGCVCPPG LVSDGSGGCI 850
AEEDCPCVHN EATYKPGETI RVDCNTCTCR NRRWECSHRL CLGTCVAYGD 900
GHFITFDGDR YSFEGSCEYI LAQDYCGDNT THGTFRIVTE NIPCGTTGTT 950
CSKAIKLFVE SYELILQEGT FKAVARGPGG DPPYKIRYMG IFLVIETHGM 1000
AVSWDRKTSV FIRLHQDYKG RVCGLCGNFD DNAINDFATR SRSVVGDALE 1050
FGNSWKLSPS CPDALAPKDP CTANPFRKSW AQKQCSILHG PTFAACRSQV 1100
DSTKYYEACV NDACACDSGG DCECFCTAVA AYAQACHDAG LCVSWRTPDT 1150
CPLFCDFYNP HGGCEWHYQP CGAPCLKTCR NPSGHCLVDL PGLEGCYPKC 1200
PPSQPFFNED QMKCVAQCGC YDKDGNYYDV GARVPTAENC QSCNCTPSGI 1250
QCAHSLEACT CTYEDRTYSY QDVIYNTTDG LGACLIAICG SNGTIIRKAV 1300
ACPGTPATTP FTFTTAWVPH STTSPALPVS TVCVREVCRW SSWYNGHRPE 1350
PGLGGGDFET FENLRQRGYQ VCPVLADIEC RAAQLPDMPL EELGQQVDCD 1400
RMRGLMCANS QQSPPLCHDY ELRVLCCEYV PCGPSPAPGT SPQPSLSAST 1450
EPAVPTPTQT TATEKTTLWV TPSIRSTAAL TSQTGSSSGP VTVTPSAPGT 1500
TTCQPRCQWT EWFDEDYPKS EQLGGDVESY DKIRAAGGHL CQQPKDIECQ 1550
AESFPNWTLA QVGQKVHCDV HFGLVCRNWE QEGVFKMCYN YRIRVLCCSD 1600
DHCRGRATTP PPTTELETAT TTTTQALFST PQPTSSPGLT RAPPASTTAV 1650
PTLSEGLTSP RYTSTLGTAT TGGPTTPAGS TEPTVPGVAT STLPTRSALP 1700
GTTGSLGTWR PSQPPTLAPT TMATSRARPT GTASTASKEP LTTSLAPTLT 1750
SELSTSQAET STPRTETTMS PLTNTTTSQG TTRCQPKCEW TEWFDVDFPT 1800
SGVAGGDMET FENIRAAGGK MCWAPKSIEC RAENYPEVSI DQVGQVLTCS 1850
LETGLTCKNE DQTGRFNMCF NYNVRVLCCD DYSHCPSTPA TSSTATPSST 1900
PGTTWILTKP TTTATTTAST GSTATPTSTL RTAPPPKVLT TTATTPTVTS 1950
SKATPSSSPG TATALPALRS TATTPTATSV TPIPSSSLGT TWTRLSQTTT 2000
PTATMSTATP SSTPETAHTS TVLTATATTT GATGSVATPS STPGTAHTTK 2050
VPTTTTTGFT ATPSSSPGTA LTPPVWISTT TTPTTRGSTV TPSSIPGTTH 2100
TATVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI TATGSTTNPS 2150
STPGTTPIPP VLTTTATTPA ATSNTVTPSS ALGTTHTPPV PNTMATTHGR 2200
SLPPSSPHTV RTAWTSATSG ILGTTHITEP STVTSHTLAA TTGTTQHSTP 2250
ALSSPHPSSR TTESPPSPGT TTPGHTTATS RTTATATPSK TRTSTLLPSS 2300
PTSAPITTVV TMGCEPQCAW SEWLDYSYPM PGPSGGDFDT YSNIRAAGGA 2350
VCEQPLGLEC RAQAQPGVPL RELGQVVECS LDFGLVCRNR EQVGKFKMCF 2400
NYEIRVFCCN YGHCPSTPAT SSTAMPSSTP GTTWILTELT TTATTTESTG 2450
STATPSSTPG TTWILTEPST TATVTVPTGS TATASSTQAT AGTPHVSTTA 2500
TTPTVTSSKA TPFSSPGTAT ALPALRSTAT TPTATSFTAI PSSSLGTTWT 2550
RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTATTTGAT GSVATPSSTP 2600
GTAHTTKVLT TTTTGFTATP SSSPGTARTL PVWISTTTTP TTRGSTVTPS 2650
SIPGTTHTPT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT 2700
GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT 2750
TATTHGRSLS PSSPHTVRTA WTSATSGTLG TTHITEPSTG TSHTPAATTG 2800
TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRATSRTT ATATPSKTRT 2850
STLLPSSPTS APITTVVTMG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN 2900
IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV 2950
GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTEQTTAA 3000
TTTATTGSTA IPSSTPGTAP PPKVLTSTAT TPTATSSKAT SSSSPRTATT 3050
LPVLTSTATK STATSFTPIP SFTLGTTGTL PEQTTTPMAT MSTIHPSSTP 3100
ETTHTSTVLT TKATTTRATS SMSTPSSTPG TTWILTELTT AATTTAATGP 3150
TATPSSTPGT TWILTEPSTT ATVTVPTGST ATASSTRATA GTLKVLTSTA 3200
TTPTVISSRA TPSSSPGTAT ALPALRSTAT TPTATSVTAI PSSSLGTAWT 3250
RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTTTTTRAT GSVATPSSTP 3300
GTAHTTKVPT TTTTGFTATP SSSPGTALTP PVWISTTTTP TTRGSTVTPS 3350
SIPGTTHTAT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT 3400
GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT 3450
TATTHGRSLP PSSPHTVRTA WTSATSGILG TTHITEPSTV TSHTPAATTS 3500
TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRGTSRTT ATATPSKTRT 3550
STLLPSSPTS APITTVVTTG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN 3600
IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV 3650
GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTKLTTTA 3700
TTTESTGSTA TPSSTPGTTW ILTEPSTTAT VTVPTGSTAT ASSTQATAGT 3750
PHVSTTATTP TVTSSKATPF SSPGTATALP ALRSTATTPT ATSFTAIPSS 3800
SLGTTWTRLS QTTTPTATMS TATPSSTPET AHTSTVLTTT ATTTRATGSV 3850
ATPSSTPGTA HTTKVPTTTT TGFTVTPSSS PGTARTPPVW ISTTTTPTTS 3900
GSTVTPSSVP GTTHTPTVLT TTTTTVATGS MATPSSSTQT SGTPPSLITT 3950
ATTITATGST TNPSSTPGTT PIPPVLTTTA TTPAATSSTV TPSSALGTTH 4000
TPPVPNTTAT THGRSLSPSS PHTVRTAWTS ATSGTLGTTH ITEPSTGTSH 4050
TPAATTGTTQ HSTPALSSPH PSSRTTESPP SPGTTTPGHT TATSRTTATA 4100
TPSKTRTSTL LPSSPTSAPI TTVVTTGCEP QCAWSEWLDY SYPMPGPSGG 4150
DFDTYSNIRA AGGAVCEQPL GLECRAQAQP GVPLGELGQV VECSLDFGLV 4200
CRNREQVGKF KMCFNYEIRV FCCNYGHCPS TPATSSTAMP SSTPGTTWIL 4250
TELTTTATTT ASTGSTATPS STPGTAPPPK VLTSPATTPT ATSSKATSSS 4300
SPRTATTLPV LTSTATKSTA TSVTPIPSST LGTTGTLPEQ TTTPVATMST 4350
IHPSSTPETT HTSTVLTTKA TTTRATSSTS TPSSTPGTTW ILTELTTAAT 4400
TTAATGPTAT PSSTPGTTWI LTELTTTATT TASTGSTATP SSTPGTTWIL 4450
TEPSTTATVT VPTGSTATAS STQATAGTPH VSTTATTPTV TSSKATPSSS 4500
PGTATALPAL RSTATTPTAT SFTAIPSSSL GTTWTRLSQT TTPTATMSTA 4550
TPSSTPETVH TSTVLTATAT TTGATGSVAT PSSTPGTAHT TKVPTTTTTG 4600
FTATPSSSPG TALTPPVWIS TTTTPTTTTP TTSGSTVTPS SIPGTTHTAR 4650
VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP 4700
GTTPITPVLT STATTPAATS SKATSSSSPR TATTLPVLTS TATKSTATSF 4750
TPIPSSTLWT TWTVPAQTTT PMSTMSTIHT SSTPETTHTS TVLTTTATMT 4800
RATNSTATPS STLGTTRILT ELTTTATTTA ATGSTATLSS TPGTTWILTE 4850
PSTIATVMVP TGSTATASST LGTAHTPKVV TTMATMPTAT ASTVPSSSTV 4900
GTTRTPAVLP SSLPTFSVST VSSSVLTTLR PTGFPSSHFS TPCFCRAFGQ 4950
FFSPGEVIYN KTDRAGCHFY AVCNQHCDID RFQGACPTSP PPVSSAPLSS 5000
PSPAPGCDNA IPLRQVNETW TLENCTVARC VGDNRVVLLD PKPVANVTCV 5050
NKHLPIKVSD PSQPCDFHYE CECICSMWGG SHYSTFDGTS YTFRGNCTYV 5100
LMREIHARFG NLSLYLDNHY CTASATAAAA RCPRALSIHY KSMDIVLTVT 5150
MVHGKEEGLI LFDQIPVSSG FSKNGVLVSV LGTTTMRVDI PALGVSVTFN 5200
GQVFQARLPY SLFHNNTEGQ CGTCTNNQRD DCLQRDGTTA ASCKDMAKTW 5250
LVPDSRKDGC WAPTGTPPTA SPAAPVSSTP TPTPCPPQPL CDLMLSQVFA 5300
ECHNLVPPGP FFNACISDHC RGRLEVPCQS LEAYAELCRA RGVCSDWRGA 5350
TGGLCDLTCP PTKVYKPCGP IQPATCNSRN QSPQLEGMAE GCFCPEDQIL 5400
FNAHMGICVQ ACPCVGPDGF PKFPGERWVS NCQSCVCDEG SVSVQCKPLP 5450
CDAQGQPPPC NRPGFVTVTR PRAENPCCPE TVCVCNTTTC PQSLPVCPPG 5500
QESICTQEEG DCCPTFRCRP QLCSYNGTFY GVGATFPGAL PCHMCTCLSG 5550
DTQDPTVQCQ EDACNNTTCP QGFEYKRVAG QCCGECVQTA CLTPDGQPVQ 5600
LNETWVNSHV DNCTVYLCEA EGGVHLLTPQ PASCPDVSSC RGSLRKTGCC 5650
YSCEEDSCQV RINTTILWHQ GCETEVNITF CEGSCPGASK YSAEAQAMQH 5700
QCTCCQERRV HEETVPLHCP NGSAILHTYT HVDECGCTPF CVPAPMAPPH 5750
TRGFPAQEAT AV 5762
Length:5,762
Mass (Da):596,340
Last modified:October 5, 2010 - v3
Checksum:i1FEC7CDCD0ADA81C
GO

Sequence cautioni

The sequence CAA06167.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341E → G.2 Publications
Corresponds to variant rs2672785 [ dbSNP | Ensembl ].
VAR_063616
Natural varianti51 – 511R → W.
Corresponds to variant rs2075853 [ dbSNP | Ensembl ].
VAR_056588
Natural varianti1360 – 13601T → M.
Corresponds to variant rs12363494 [ dbSNP | Ensembl ].
VAR_059538
Natural varianti1401 – 14011R → H.
Corresponds to variant rs10835639 [ dbSNP | Ensembl ].
VAR_059539
Natural varianti1805 – 18051G → S.1 Publication
Corresponds to variant rs1541314 [ dbSNP | Ensembl ].
VAR_063617
Natural varianti1889 – 18891P → L.1 Publication
Corresponds to variant rs2943510 [ dbSNP | Ensembl ].
VAR_063618
Natural varianti2025 – 20251A → T.1 Publication
Corresponds to variant rs34739266 [ dbSNP | Ensembl ].
VAR_063619
Natural varianti2027 – 20271A → T.
Corresponds to variant rs2943531 [ dbSNP | Ensembl ].
VAR_059540
Natural varianti2194 – 21941M → T.1 Publication
Corresponds to variant rs2943502 [ dbSNP | Ensembl ].
VAR_063620
Natural varianti2238 – 22381L → P.1 Publication
Corresponds to variant rs4963031 [ dbSNP | Ensembl ].
VAR_063621
Natural varianti2425 – 24251M → T.1 Publication
Corresponds to variant rs3965632 [ dbSNP | Ensembl ].
VAR_063622
Natural varianti2559 – 25591T → M.
Corresponds to variant rs2860722 [ dbSNP | Ensembl ].
VAR_059541
Natural varianti3072 – 30721F → S.1 Publication
Corresponds to variant rs3021161 [ dbSNP | Ensembl ].
VAR_063623
Natural varianti3284 – 32841T → A.1 Publication
Corresponds to variant rs2943531 [ dbSNP | Ensembl ].
VAR_063624
Natural varianti3468 – 34681R → P.1 Publication
Corresponds to variant rs2943529 [ dbSNP | Ensembl ].
VAR_063625
Natural varianti3816 – 38161T → M.1 Publication
Corresponds to variant rs75917341 [ dbSNP | Ensembl ].
VAR_063626
Natural varianti4404 – 44041A → G.1 Publication
Corresponds to variant rs2943517 [ dbSNP | Ensembl ].
VAR_063627
Natural varianti4440 – 44401P → L.1 Publication
Corresponds to variant rs2943516 [ dbSNP | Ensembl ].
VAR_063628
Natural varianti4706 – 47061T → P.1 Publication
Corresponds to variant rs2943512 [ dbSNP | Ensembl ].
VAR_063629
Natural varianti4712 – 47121T → M.1 Publication
Corresponds to variant rs2943511 [ dbSNP | Ensembl ].
VAR_063630
Natural varianti4867 – 48671A → T.1 Publication
Corresponds to variant rs3021155 [ dbSNP | Ensembl ].
VAR_063631
Natural varianti4882 – 48821T → A.1 Publication
Corresponds to variant rs3021156 [ dbSNP | Ensembl ].
VAR_063632
Natural varianti5196 – 51961S → T.1 Publication
Corresponds to variant rs2672788 [ dbSNP | Ensembl ].
VAR_014123

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 1006FPGLCN → LPCLCK in AAC67545. 1 Publication
Sequence conflicti104 – 1041S → C in AAC67545. 1 Publication
Sequence conflicti142 – 1421E → K in AAG33673. 1 Publication
Sequence conflicti225 – 2251R → S in AAC67545. 1 Publication
Sequence conflicti330 – 3312PL → T in AAC67545. 1 Publication
Sequence conflicti337 – 3371E → N in AAC67545. 1 Publication
Sequence conflicti356 – 3561E → K in AAC67545. 1 Publication
Sequence conflicti362 – 3621G → R in AAC67545. 1 Publication
Sequence conflicti368 – 3681G → GS in AAG33673. 1 Publication
Sequence conflicti373 – 3731D → N in AAC67545. 1 Publication
Sequence conflicti392 – 3932RT → TR in AAC67545. 1 Publication
Sequence conflicti467 – 4682RK → GR in AAC67545. 1 Publication
Sequence conflicti511 – 5111L → P in AAC67545. 1 Publication
Sequence conflicti584 – 5863GAA → AH in CAA06167. 1 Publication
Sequence conflicti600 – 6001A → S in CAA06167. 1 Publication
Sequence conflicti627 – 6282DP → RS in AAC67545. 1 Publication
Sequence conflicti632 – 6321F → L in AAC67545. 1 Publication
Sequence conflicti675 – 6751A → P in CAA06167. 1 Publication
Sequence conflicti700 – 7001R → P in CAA06167. 1 Publication
Sequence conflicti751 – 7511E → K in AAC67545. 1 Publication
Sequence conflicti811 – 8111P → L in AAC67545. 1 Publication
Sequence conflicti816 – 8172LR → DG in AAC67545. 1 Publication
Sequence conflicti859 – 8602HN → NK in AAC67545. 1 Publication
Sequence conflicti866 – 8661P → L in AAC67545. 1 Publication
Sequence conflicti872 – 8721V → F in AAC67545. 1 Publication
Sequence conflicti883 – 8831R → T in AAC67545. 1 Publication
Sequence conflicti889 – 8891R → G in CAA06167. 1 Publication
Sequence conflicti1020 – 10201G → A in AAC67545. 1 Publication
Sequence conflicti1082 – 10821Q → E in AAC67545. 1 Publication
Sequence conflicti1144 – 11441S → C in CAA06167. 1 Publication
Sequence conflicti1195 – 11951G → R in AAC67545. 1 Publication
Sequence conflicti1207 – 12071Missing in AAC67545. 1 Publication
Sequence conflicti1291 – 12911S → T in CAA06167. 1 Publication
Sequence conflicti1317 – 13171Missing in AAC67545. 1 Publication
Sequence conflicti1675 – 16773TTP → RQS in CAA96577. 1 Publication
Sequence conflicti1926 – 19272PT → AS in CAA96577. 1 Publication
Sequence conflicti1930 – 19312LR → QA in CAA96577. 1 Publication
Sequence conflicti1934 – 19407PPPKVLT → GTPHVS in CAA96577. 1 Publication
Sequence conflicti1956 – 19561S → F in CAA96577. 1 Publication
Sequence conflicti1980 – 19823VTP → FTA in CAA96577. 1 Publication
Sequence conflicti2002 – 20021T → M in CAA96577. 1 Publication
Sequence conflicti2017 – 20171A → V in CAA96577. 1 Publication
Sequence conflicti2052 – 20521P → L in CAA96577. 1 Publication
Sequence conflicti2069 – 20735TALTP → RARTL in CAA96577. 1 Publication
Sequence conflicti2102 – 21021A → P in CAA96577. 1 Publication
Sequence conflicti2174 – 21741N → S in CAA96577. 1 Publication
Sequence conflicti2203 – 22031P → S in CAA96577. 1 Publication
Sequence conflicti2211 – 22111R → C in CAA96577. 1 Publication
Sequence conflicti2233 – 22331V → G in CAA96577. 1 Publication
Sequence conflicti2300 – 23001S → Q in CAA96577. 1 Publication
Sequence conflicti2333 – 23331P → S in AAB61398. 1 Publication
Sequence conflicti2456 – 249742SSTPG…TPHVS → TSTLRTAPPPKVLT in CAA96577. 1 Publication
Add
BLAST
Sequence conflicti2461 – 24622TT → DD in AAB61398. 1 Publication
Sequence conflicti2468 – 36951228Missing in AAB61398. 1 Publication
Add
BLAST
Sequence conflicti2513 – 25131F → S in CAA96577. 1 Publication
Sequence conflicti2537 – 25393FTA → VTP in CAA96577. 1 Publication
Sequence conflicti2574 – 25741V → A in CAA96577. 1 Publication
Sequence conflicti2582 – 25821T → A in CAA96577. 1 Publication
Sequence conflicti2609 – 26091L → P in CAA96577. 1 Publication
Sequence conflicti2628 – 26303RTL → LTP in CAA96577. 1 Publication
Sequence conflicti2659 – 26591P → A in CAA96577. 1 Publication
Sequence conflicti2713 – 27131T → R in CAA96577. 1 Publication
Sequence conflicti2834 – 28341R → T in CAA96577. 1 Publication
Sequence conflicti3028 – 30281T → Q in CAA96577. 1 Publication
Sequence conflicti3080 – 30867LPEQTTT → SQNRPPH in CAA96577. 1 Publication
Sequence conflicti3148 – 31525TGPTA → LPHG in CAA96577. 1 Publication
Sequence conflicti3289 – 32891Missing in CAA96577. 1 Publication
Sequence conflicti3490 – 34901V → G in CAA96577. 1 Publication
Sequence conflicti3500 – 35001S → G in CAA96577. 1 Publication
Sequence conflicti3504 – 35041H → P in CAA96577. 1 Publication
Sequence conflicti3716 – 374732PGTTW…STQAT → QGPP in CAA96577. 1 Publication
Add
BLAST
Sequence conflicti3811 – 38111Q → P in AAB61398. 1 Publication
Sequence conflicti3831 – 38311A → V in CAA96577. 1 Publication
Sequence conflicti3845 – 38451R → G in CAA96577. 1 Publication
Sequence conflicti3909 – 39091V → I in CAA96577. 1 Publication
Sequence conflicti3924 – 39252TT → QP in CAA96577. 1 Publication
Sequence conflicti3975 – 39751V → E in CAA96577. 1 Publication
Sequence conflicti4060 – 40612QH → TT in CAA96577. 1 Publication
Sequence conflicti4114 – 41141S → Q in CAA96577. 1 Publication
Sequence conflicti4177 – 41771Q → T in CAA96577. 1 Publication
Sequence conflicti4313 – 43131S → T in CAA52910. 1 Publication
Sequence conflicti4373 – 43731Missing in CAA96577. 1 Publication
Sequence conflicti4461 – 44633VPT → APP in CAA96577. 1 Publication
Sequence conflicti4567 – 45671A → T in CAA96577. 1 Publication
Sequence conflicti4780 – 47801T → P in AAC51344. 1 Publication
Sequence conflicti5134 – 51341R → A in AAB65151. 1 Publication
Sequence conflicti5164 – 51641Q → P in AAB65151. 1 Publication
Sequence conflicti5187 – 51871R → A in AAC51344. 1 Publication
Sequence conflicti5187 – 51871R → A in AAB65151. 1 Publication
Sequence conflicti5289 – 52891P → L in AAB65151. 1 Publication
Sequence conflicti5304 – 53063NLV → TLL in AAB65151. 1 Publication
Sequence conflicti5333 – 53331A → R in AAC51344. 1 Publication
Sequence conflicti5397 – 53971D → N in AAC51343. 1 Publication
Sequence conflicti5397 – 53971D → N in AAC51344. 1 Publication
Sequence conflicti5474 – 54741E → R in CAA70926. 1 Publication
Sequence conflicti5475 – 54751N → T in AAB65151. 1 Publication
Sequence conflicti5620 – 56201A → S in AAB65151. 1 Publication
Sequence conflicti5632 – 56321A → D in AAC51343. 1 Publication
Sequence conflicti5660 – 56601V → C in AAB65151. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF107890 Genomic DNA. Translation: AAG33673.1.
AF086604 mRNA. Translation: AAC67545.1.
AJ004862 Genomic DNA. Translation: CAA06167.1. Different initiation.
X74955 mRNA. Translation: CAA52910.1.
Z72496 Genomic DNA. Translation: CAA96577.1.
U63836 mRNA. Translation: AAB61398.1.
U78551 mRNA. Translation: AAC51343.1.
AH006676 Genomic DNA. Translation: AAC51344.1.
U95031 mRNA. Translation: AAB65151.1.
Y09788 Genomic DNA. Translation: CAA70926.1.
CCDSiCCDS44515.2.
PIRiA33811.
T45025.
RefSeqiNP_002449.2. NM_002458.2.
UniGeneiHs.523395.

Genome annotation databases

EnsembliENST00000529681; ENSP00000436812; ENSG00000117983.
GeneIDi727897.
KEGGihsa:727897.
UCSCiuc001lta.3. human.

Polymorphism databases

DMDMi308153579.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF107890 Genomic DNA. Translation: AAG33673.1 .
AF086604 mRNA. Translation: AAC67545.1 .
AJ004862 Genomic DNA. Translation: CAA06167.1 . Different initiation.
X74955 mRNA. Translation: CAA52910.1 .
Z72496 Genomic DNA. Translation: CAA96577.1 .
U63836 mRNA. Translation: AAB61398.1 .
U78551 mRNA. Translation: AAC51343.1 .
AH006676 Genomic DNA. Translation: AAC51344.1 .
U95031 mRNA. Translation: AAB65151.1 .
Y09788 Genomic DNA. Translation: CAA70926.1 .
CCDSi CCDS44515.2.
PIRi A33811.
T45025.
RefSeqi NP_002449.2. NM_002458.2.
UniGenei Hs.523395.

3D structure databases

ProteinModelPortali Q9HC84.
ModBasei Search...

Protein-protein interaction databases

BioGridi 608337. 4 interactions.

Protein family/group databases

MEROPSi I08.953.

PTM databases

PhosphoSitei Q9HC84.

Polymorphism databases

DMDMi 308153579.

Proteomic databases

MaxQBi Q9HC84.
PaxDbi Q9HC84.
PRIDEi Q9HC84.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000529681 ; ENSP00000436812 ; ENSG00000117983 .
GeneIDi 727897.
KEGGi hsa:727897.
UCSCi uc001lta.3. human.

Organism-specific databases

CTDi 727897.
GeneCardsi GC11P001244.
H-InvDB HIX0035863.
HIX0171268.
HIX0171346.
HGNCi HGNC:7516. MUC5B.
HPAi CAB009396.
HPA008246.
MIMi 178500. phenotype.
600770. gene.
neXtProti NX_Q9HC84.
Orphaneti 171700. Diffuse panbronchiolitis.
2032. Idiopathic pulmonary fibrosis.
PharmGKBi PA31321.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOVERGENi HBG052535.
InParanoidi Q9HC84.
KOi K13908.
TreeFami TF300299.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSi MUC5B. human.
GeneWikii MUC5B.
GenomeRNAii 727897.
NextBioi 125477.
PROi Q9HC84.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9HC84.
Bgeei Q9HC84.
Genevestigatori Q9HC84.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view ]
Pfami PF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 7 hits.
PF01826. TIL. 3 hits.
PF00093. VWC. 1 hit.
PF00094. VWD. 4 hits.
[Graphical view ]
SMARTi SM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 3 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 4 hits.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 4 hits.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region."
    Chen Y., Zhao Y.H., Di Y.P., Wu R.
    Am. J. Respir. Cell Mol. Biol. 25:542-553(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1593, INDUCTION, TISSUE SPECIFICITY, VARIANT GLY-34.
  2. "The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions."
    Offner G.D., Nunes D.P., Keates A.C., Afdhal N.H., Troxler R.F.
    Biochem. Biophys. Res. Commun. 251:350-355(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1324.
  3. "Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon."
    Desseyn J.-L., Buisine M.P., Porchet N., Aubert J.-P., Laine A.
    J. Biol. Chem. 273:30157-30164(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-1323, VARIANT GLY-34.
  4. "Human mucin gene MUC5B, the 10.7 kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family."
    Desseyn J.-L., Guyonnet-Duperat V., Porchet N., Aubert J.-P., Laine A.
    J. Biol. Chem. 272:3168-3178(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1325-4954, NUCLEOTIDE SEQUENCE [MRNA] OF 4170-4791, VARIANTS SER-1805; LEU-1889; THR-2025; THR-2194; PRO-2238; THR-2425; SER-3072; ALA-3284; PRO-3468; MET-3816; GLY-4404; LEU-4440; PRO-4706; MET-4712; THR-4867 AND ALA-4882.
    Tissue: Placenta and Tracheobronchial mucosa.
  5. "Proteolytic fragmentation and peptide mapping of human carboxyamidomethylated tracheobronchial mucin."
    Rose M.C., Kaufman B., Martin B.M.
    J. Biol. Chem. 264:8193-8199(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2346-2358; 2903-2915; 3603-3615 AND 4160-4172.
    Tissue: Tracheobronchial mucosa.
  6. "Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B."
    Nielsen P.A., Bennett E.P., Wandall H.H., Therkildsen M.H., Hannibal J., Clausen H.
    Glycobiology 7:413-419(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2301-3811, TISSUE SPECIFICITY.
    Tissue: Salivary gland.
  7. "Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B."
    Keates A.C., Nunes D.P., Afdhal N.H., Troxler R.F., Offner G.D.
    Biochem. J. 324:295-303(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4780-5423, NUCLEOTIDE SEQUENCE [MRNA] OF 5373-5762, TISSUE SPECIFICITY.
    Tissue: Gall bladder.
  8. "Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland."
    Troxler R.F., Offner G.D., Zhang F., Iontcheva I., Oppenheim F.G.
    Biochem. Biophys. Res. Commun. 217:1112-1119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4868-5746, TISSUE SPECIFICITY.
    Tissue: Sublingual gland.
  9. "Genomic organization of the 3 region of the human MUC5B mucin."
    Desseyn J.-L., Aubert J.-P., Porchet N., Laine A.
    J. Biol. Chem. 272:16873-16883(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4918-5762, VARIANT THR-5196.
    Tissue: Placenta.
  10. Cited for: STRUCTURE OF O-LINKED CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
  11. "C-Mannosylation of MUC5AC and MUC5B Cys subdomains."
    Perez-Vilar J., Randell S.H., Boucher R.C.
    Glycobiology 14:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, MUTAGENESIS OF TRP-1790.
  12. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145; ASN-254; ASN-1556; ASN-4960; ASN-5017; ASN-5024; ASN-5046; ASN-5096; ASN-5111 AND ASN-5215.
    Tissue: Saliva.
  13. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO IPF.
  14. "A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis."
    Zhang Y., Noth I., Garcia J.G., Kaminski N.
    N. Engl. J. Med. 364:1576-1577(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO IPF.

Entry informationi

Entry nameiMUC5B_HUMAN
AccessioniPrimary (citable) accession number: Q9HC84
Secondary accession number(s): O00447
, O00573, O14985, O15494, O95291, O95451, Q14881, Q7M4S5, Q99552, Q9UE28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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