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Q9HC84

- MUC5B_HUMAN

UniProt

Q9HC84 - MUC5B_HUMAN

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Protein

Mucin-5B

Gene

MUC5B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. cellular response to epidermal growth factor stimulus Source: Ensembl
  3. cellular response to glucocorticoid stimulus Source: Ensembl
  4. cellular response to retinoic acid Source: Ensembl
  5. epithelial cell differentiation Source: Ensembl
  6. O-glycan processing Source: Reactome
  7. post-translational protein modification Source: Reactome
  8. response to lipopolysaccharide Source: Ensembl
  9. response to ozone Source: Ensembl
  10. response to sulfur dioxide Source: Ensembl
  11. response to vitamin A Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Protein family/group databases

MEROPSiI08.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-5B
Short name:
MUC-5B
Alternative name(s):
Cervical mucin
High molecular weight salivary mucin MG1
Mucin-5 subtype B, tracheobronchial
Sublingual gland mucin
Gene namesi
Name:MUC5B
Synonyms:MUC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:7516. MUC5B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. extracellular vesicular exosome Source: UniProtKB
  3. Golgi lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease.2 Publications
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741).1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1790 – 17901W → A: Poorly secreted. 1 Publication

Organism-specific databases

MIMi178500. phenotype.
Orphaneti171700. Diffuse panbronchiolitis.
2032. Idiopathic pulmonary fibrosis.
PharmGKBiPA31321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 57625737Mucin-5BPRO_0000019283Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 5741By similarity
Disulfide bondi99 ↔ 107By similarity
Glycosylationi145 – 1451N-linked (GlcNAc...)1 Publication
Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi254 – 2541N-linked (GlcNAc...)1 Publication
Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi447 ↔ 455By similarity
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi805 – 8051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi929 – 9291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1276 – 12761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1292 – 12921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1340 – 13401C-linked (Man)Curated
Glycosylationi1509 – 15091C-linked (Man)Curated
Glycosylationi1556 – 15561N-linked (GlcNAc...)1 Publication
Glycosylationi1774 – 17741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1790 – 17901C-linked (Man)Curated
Glycosylationi2320 – 23201C-linked (Man)Curated
Glycosylationi2749 – 27491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2877 – 28771C-linked (Man)Curated
Glycosylationi3449 – 34491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3577 – 35771C-linked (Man)Curated
Glycosylationi4006 – 40061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4134 – 41341C-linked (Man)Curated
Glycosylationi4804 – 48041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4960 – 49601N-linked (GlcNAc...)1 Publication
Glycosylationi5017 – 50171N-linked (GlcNAc...)1 Publication
Glycosylationi5024 – 50241N-linked (GlcNAc...)1 Publication
Glycosylationi5046 – 50461N-linked (GlcNAc...)1 Publication
Glycosylationi5096 – 50961N-linked (GlcNAc...)1 Publication
Glycosylationi5111 – 51111N-linked (GlcNAc...)1 Publication
Glycosylationi5215 – 52151N-linked (GlcNAc...)1 Publication
Glycosylationi5486 – 54861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5526 – 55261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5565 – 55651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5566 – 55661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5602 – 56021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5612 – 56121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi5653 ↔ 5705By similarity
Glycosylationi5663 – 56631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi5672 ↔ 5719By similarity
Glycosylationi5677 – 56771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi5681 ↔ 5735By similarity
Disulfide bondi5685 ↔ 5737By similarity
Glycosylationi5721 – 57211N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc2Hex1HexNac1-ol.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9HC84.
PaxDbiQ9HC84.
PRIDEiQ9HC84.

PTM databases

PhosphoSiteiQ9HC84.

Expressioni

Tissue specificityi

Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas.4 Publications

Inductioni

Regulated by all-trans-retinoic acid (ATRA) in a cell-type specific manner.1 Publication

Gene expression databases

BgeeiQ9HC84.
ExpressionAtlasiQ9HC84. baseline and differential.
GenevestigatoriQ9HC84.

Organism-specific databases

HPAiCAB009396.
HPA008246.

Interactioni

Protein-protein interaction databases

BioGridi608337. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9HC84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 277202VWFD 1PROSITE-ProRule annotationAdd
BLAST
Domaini329 – 38557TIL 1Add
BLAST
Domaini424 – 638215VWFD 2PROSITE-ProRule annotationAdd
BLAST
Domaini695 – 75258TIL 2Add
BLAST
Domaini805 – 85551TIL 3Add
BLAST
Domaini855 – 92773VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini894 – 1099206VWFD 3PROSITE-ProRule annotationAdd
BLAST
Repeati1333 – 1432100Cys-rich subdomain 1Add
BLAST
Repeati1503 – 1604102Cys-rich subdomain 2Add
BLAST
Repeati1784 – 1885102Cys-rich subdomain 3Add
BLAST
Repeati2313 – 2414102Cys-rich subdomain 4Add
BLAST
Repeati2854 – 288633HAT 1Add
BLAST
Repeati2871 – 2971101Cys-rich subdomain 5Add
BLAST
Repeati3554 – 358633HAT 2Add
BLAST
Repeati3571 – 3671101Cys-rich subdomain 6Add
BLAST
Repeati4111 – 414333HAT 3Add
BLAST
Repeati4128 – 4228101Cys-rich subdomain 7Add
BLAST
Domaini5074 – 5305232VWFD 4PROSITE-ProRule annotationAdd
BLAST
Domaini5412 – 548473VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini5521 – 558767VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini5653 – 574290CTCKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1333 – 422828967 X Cys-rich subdomain repeatsAdd
BLAST
Regioni1890 – 219931011 X approximate tandem repeats, Ser/Thr-richAdd
BLAST
Regioni2419 – 275633811 X approximate tandem repeats, Ser/Thr-richAdd
BLAST
Regioni2976 – 345648117 X approximate tandem repeats, Ser/Thr-richAdd
BLAST
Regioni3676 – 401333811 X approximate tandem repeats, Ser/Thr-richAdd
BLAST
Regioni4233 – 487964723 X approximate tandem repeats, Ser/Thr-richAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1109 – 1261153Cys-richAdd
BLAST
Compositional biasi1456 – 150247Thr-richAdd
BLAST
Compositional biasi1608 – 49323325Thr-richAdd
BLAST

Domaini

The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 3 HAT repeats.Curated
Contains 3 VWFC domains.PROSITE-ProRule annotation
Contains 4 VWFD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118896.
HOVERGENiHBG052535.
InParanoidiQ9HC84.
KOiK13908.
TreeFamiTF300299.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view]
PfamiPF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 7 hits.
PF01826. TIL. 3 hits.
PF00093. VWC. 1 hit.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTiSM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 3 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 4 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HC84-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGAPSACRTL VLALAAMLVV PQAETQGPVE PSWENAGHTM DGGAPTSSPT
60 70 80 90 100
RRVSFVPPVT VFPSLSPLNP AHNGRVCSTW GDFHYKTFDG DVFRFPGLCN
110 120 130 140 150
YVFSEHCRAA YEDFNVQLRR GLVGSRPVVT RVVIKAQGLV LEASNGSVLI
160 170 180 190 200
NGQREELPYS RTGLLVEQSG DYIKVSIRLV LTFLWNGEDS ALLELDPKYA
210 220 230 240 250
NQTCGLCGDF NGLPAFNEFY AHNARLTPLQ FGNLQKLDGP TEQCPDPLPL
260 270 280 290 300
PAGNCTDEEG ICHRTLLGPA FAECHALVDS TAYLAACAQD LCRCPTCPCA
310 320 330 340 350
TFVEYSRQCA HAGGQPRNWR CPELCPRTCP LNMQHQECGS PCTDTCSNPQ
360 370 380 390 400
RAQLCEDHCV DGCFCPPGTV LDDITHSGCL PLGQCPCTHG GRTYSPGTSF
410 420 430 440 450
NTTCSSCTCS GGLWQCQDLP CPGTCSVQGG AHISTYDEKL YDLHGDCSYV
460 470 480 490 500
LSKKCADSSF TVLAELRKCG LTDNENCLKA VTLSLDGGDT AIRVQADGGV
510 520 530 540 550
FLNSIYTQLP LSAANITLFT PSSFFIVVQT GLGLQLLVQL VPLMQVFVRL
560 570 580 590 600
DPAHQGQMCG LCGNFNQNQA DDFTALSGVV EATGAAFANT WKAQAACANA
610 620 630 640 650
RNSFEDPCSL SVENENYARH WCSRLTDPNS AFSRCHSIIN PKPFHSNCMF
660 670 680 690 700
DTCNCERSED CLCAALSSYV HACAAKGVQL SDWRDGVCTK YMQNCPKSQR
710 720 730 740 750
YAYVVDACQP TCRGLSEADV TCSVSFVPVD GCTCPAGTFL NDAGACVPAQ
760 770 780 790 800
ECPCYAHGTV LAPGEVVHDE GAVCSCTGGK LSCLGASLQK STGCAAPMVY
810 820 830 840 850
LDCSNSSAGT PGAECLRSCH TLDVGCFSTH CVSGCVCPPG LVSDGSGGCI
860 870 880 890 900
AEEDCPCVHN EATYKPGETI RVDCNTCTCR NRRWECSHRL CLGTCVAYGD
910 920 930 940 950
GHFITFDGDR YSFEGSCEYI LAQDYCGDNT THGTFRIVTE NIPCGTTGTT
960 970 980 990 1000
CSKAIKLFVE SYELILQEGT FKAVARGPGG DPPYKIRYMG IFLVIETHGM
1010 1020 1030 1040 1050
AVSWDRKTSV FIRLHQDYKG RVCGLCGNFD DNAINDFATR SRSVVGDALE
1060 1070 1080 1090 1100
FGNSWKLSPS CPDALAPKDP CTANPFRKSW AQKQCSILHG PTFAACRSQV
1110 1120 1130 1140 1150
DSTKYYEACV NDACACDSGG DCECFCTAVA AYAQACHDAG LCVSWRTPDT
1160 1170 1180 1190 1200
CPLFCDFYNP HGGCEWHYQP CGAPCLKTCR NPSGHCLVDL PGLEGCYPKC
1210 1220 1230 1240 1250
PPSQPFFNED QMKCVAQCGC YDKDGNYYDV GARVPTAENC QSCNCTPSGI
1260 1270 1280 1290 1300
QCAHSLEACT CTYEDRTYSY QDVIYNTTDG LGACLIAICG SNGTIIRKAV
1310 1320 1330 1340 1350
ACPGTPATTP FTFTTAWVPH STTSPALPVS TVCVREVCRW SSWYNGHRPE
1360 1370 1380 1390 1400
PGLGGGDFET FENLRQRGYQ VCPVLADIEC RAAQLPDMPL EELGQQVDCD
1410 1420 1430 1440 1450
RMRGLMCANS QQSPPLCHDY ELRVLCCEYV PCGPSPAPGT SPQPSLSAST
1460 1470 1480 1490 1500
EPAVPTPTQT TATEKTTLWV TPSIRSTAAL TSQTGSSSGP VTVTPSAPGT
1510 1520 1530 1540 1550
TTCQPRCQWT EWFDEDYPKS EQLGGDVESY DKIRAAGGHL CQQPKDIECQ
1560 1570 1580 1590 1600
AESFPNWTLA QVGQKVHCDV HFGLVCRNWE QEGVFKMCYN YRIRVLCCSD
1610 1620 1630 1640 1650
DHCRGRATTP PPTTELETAT TTTTQALFST PQPTSSPGLT RAPPASTTAV
1660 1670 1680 1690 1700
PTLSEGLTSP RYTSTLGTAT TGGPTTPAGS TEPTVPGVAT STLPTRSALP
1710 1720 1730 1740 1750
GTTGSLGTWR PSQPPTLAPT TMATSRARPT GTASTASKEP LTTSLAPTLT
1760 1770 1780 1790 1800
SELSTSQAET STPRTETTMS PLTNTTTSQG TTRCQPKCEW TEWFDVDFPT
1810 1820 1830 1840 1850
SGVAGGDMET FENIRAAGGK MCWAPKSIEC RAENYPEVSI DQVGQVLTCS
1860 1870 1880 1890 1900
LETGLTCKNE DQTGRFNMCF NYNVRVLCCD DYSHCPSTPA TSSTATPSST
1910 1920 1930 1940 1950
PGTTWILTKP TTTATTTAST GSTATPTSTL RTAPPPKVLT TTATTPTVTS
1960 1970 1980 1990 2000
SKATPSSSPG TATALPALRS TATTPTATSV TPIPSSSLGT TWTRLSQTTT
2010 2020 2030 2040 2050
PTATMSTATP SSTPETAHTS TVLTATATTT GATGSVATPS STPGTAHTTK
2060 2070 2080 2090 2100
VPTTTTTGFT ATPSSSPGTA LTPPVWISTT TTPTTRGSTV TPSSIPGTTH
2110 2120 2130 2140 2150
TATVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI TATGSTTNPS
2160 2170 2180 2190 2200
STPGTTPIPP VLTTTATTPA ATSNTVTPSS ALGTTHTPPV PNTMATTHGR
2210 2220 2230 2240 2250
SLPPSSPHTV RTAWTSATSG ILGTTHITEP STVTSHTLAA TTGTTQHSTP
2260 2270 2280 2290 2300
ALSSPHPSSR TTESPPSPGT TTPGHTTATS RTTATATPSK TRTSTLLPSS
2310 2320 2330 2340 2350
PTSAPITTVV TMGCEPQCAW SEWLDYSYPM PGPSGGDFDT YSNIRAAGGA
2360 2370 2380 2390 2400
VCEQPLGLEC RAQAQPGVPL RELGQVVECS LDFGLVCRNR EQVGKFKMCF
2410 2420 2430 2440 2450
NYEIRVFCCN YGHCPSTPAT SSTAMPSSTP GTTWILTELT TTATTTESTG
2460 2470 2480 2490 2500
STATPSSTPG TTWILTEPST TATVTVPTGS TATASSTQAT AGTPHVSTTA
2510 2520 2530 2540 2550
TTPTVTSSKA TPFSSPGTAT ALPALRSTAT TPTATSFTAI PSSSLGTTWT
2560 2570 2580 2590 2600
RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTATTTGAT GSVATPSSTP
2610 2620 2630 2640 2650
GTAHTTKVLT TTTTGFTATP SSSPGTARTL PVWISTTTTP TTRGSTVTPS
2660 2670 2680 2690 2700
SIPGTTHTPT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT
2710 2720 2730 2740 2750
GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT
2760 2770 2780 2790 2800
TATTHGRSLS PSSPHTVRTA WTSATSGTLG TTHITEPSTG TSHTPAATTG
2810 2820 2830 2840 2850
TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRATSRTT ATATPSKTRT
2860 2870 2880 2890 2900
STLLPSSPTS APITTVVTMG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN
2910 2920 2930 2940 2950
IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV
2960 2970 2980 2990 3000
GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTEQTTAA
3010 3020 3030 3040 3050
TTTATTGSTA IPSSTPGTAP PPKVLTSTAT TPTATSSKAT SSSSPRTATT
3060 3070 3080 3090 3100
LPVLTSTATK STATSFTPIP SFTLGTTGTL PEQTTTPMAT MSTIHPSSTP
3110 3120 3130 3140 3150
ETTHTSTVLT TKATTTRATS SMSTPSSTPG TTWILTELTT AATTTAATGP
3160 3170 3180 3190 3200
TATPSSTPGT TWILTEPSTT ATVTVPTGST ATASSTRATA GTLKVLTSTA
3210 3220 3230 3240 3250
TTPTVISSRA TPSSSPGTAT ALPALRSTAT TPTATSVTAI PSSSLGTAWT
3260 3270 3280 3290 3300
RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTTTTTRAT GSVATPSSTP
3310 3320 3330 3340 3350
GTAHTTKVPT TTTTGFTATP SSSPGTALTP PVWISTTTTP TTRGSTVTPS
3360 3370 3380 3390 3400
SIPGTTHTAT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT
3410 3420 3430 3440 3450
GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT
3460 3470 3480 3490 3500
TATTHGRSLP PSSPHTVRTA WTSATSGILG TTHITEPSTV TSHTPAATTS
3510 3520 3530 3540 3550
TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRGTSRTT ATATPSKTRT
3560 3570 3580 3590 3600
STLLPSSPTS APITTVVTTG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN
3610 3620 3630 3640 3650
IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV
3660 3670 3680 3690 3700
GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTKLTTTA
3710 3720 3730 3740 3750
TTTESTGSTA TPSSTPGTTW ILTEPSTTAT VTVPTGSTAT ASSTQATAGT
3760 3770 3780 3790 3800
PHVSTTATTP TVTSSKATPF SSPGTATALP ALRSTATTPT ATSFTAIPSS
3810 3820 3830 3840 3850
SLGTTWTRLS QTTTPTATMS TATPSSTPET AHTSTVLTTT ATTTRATGSV
3860 3870 3880 3890 3900
ATPSSTPGTA HTTKVPTTTT TGFTVTPSSS PGTARTPPVW ISTTTTPTTS
3910 3920 3930 3940 3950
GSTVTPSSVP GTTHTPTVLT TTTTTVATGS MATPSSSTQT SGTPPSLITT
3960 3970 3980 3990 4000
ATTITATGST TNPSSTPGTT PIPPVLTTTA TTPAATSSTV TPSSALGTTH
4010 4020 4030 4040 4050
TPPVPNTTAT THGRSLSPSS PHTVRTAWTS ATSGTLGTTH ITEPSTGTSH
4060 4070 4080 4090 4100
TPAATTGTTQ HSTPALSSPH PSSRTTESPP SPGTTTPGHT TATSRTTATA
4110 4120 4130 4140 4150
TPSKTRTSTL LPSSPTSAPI TTVVTTGCEP QCAWSEWLDY SYPMPGPSGG
4160 4170 4180 4190 4200
DFDTYSNIRA AGGAVCEQPL GLECRAQAQP GVPLGELGQV VECSLDFGLV
4210 4220 4230 4240 4250
CRNREQVGKF KMCFNYEIRV FCCNYGHCPS TPATSSTAMP SSTPGTTWIL
4260 4270 4280 4290 4300
TELTTTATTT ASTGSTATPS STPGTAPPPK VLTSPATTPT ATSSKATSSS
4310 4320 4330 4340 4350
SPRTATTLPV LTSTATKSTA TSVTPIPSST LGTTGTLPEQ TTTPVATMST
4360 4370 4380 4390 4400
IHPSSTPETT HTSTVLTTKA TTTRATSSTS TPSSTPGTTW ILTELTTAAT
4410 4420 4430 4440 4450
TTAATGPTAT PSSTPGTTWI LTELTTTATT TASTGSTATP SSTPGTTWIL
4460 4470 4480 4490 4500
TEPSTTATVT VPTGSTATAS STQATAGTPH VSTTATTPTV TSSKATPSSS
4510 4520 4530 4540 4550
PGTATALPAL RSTATTPTAT SFTAIPSSSL GTTWTRLSQT TTPTATMSTA
4560 4570 4580 4590 4600
TPSSTPETVH TSTVLTATAT TTGATGSVAT PSSTPGTAHT TKVPTTTTTG
4610 4620 4630 4640 4650
FTATPSSSPG TALTPPVWIS TTTTPTTTTP TTSGSTVTPS SIPGTTHTAR
4660 4670 4680 4690 4700
VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP
4710 4720 4730 4740 4750
GTTPITPVLT STATTPAATS SKATSSSSPR TATTLPVLTS TATKSTATSF
4760 4770 4780 4790 4800
TPIPSSTLWT TWTVPAQTTT PMSTMSTIHT SSTPETTHTS TVLTTTATMT
4810 4820 4830 4840 4850
RATNSTATPS STLGTTRILT ELTTTATTTA ATGSTATLSS TPGTTWILTE
4860 4870 4880 4890 4900
PSTIATVMVP TGSTATASST LGTAHTPKVV TTMATMPTAT ASTVPSSSTV
4910 4920 4930 4940 4950
GTTRTPAVLP SSLPTFSVST VSSSVLTTLR PTGFPSSHFS TPCFCRAFGQ
4960 4970 4980 4990 5000
FFSPGEVIYN KTDRAGCHFY AVCNQHCDID RFQGACPTSP PPVSSAPLSS
5010 5020 5030 5040 5050
PSPAPGCDNA IPLRQVNETW TLENCTVARC VGDNRVVLLD PKPVANVTCV
5060 5070 5080 5090 5100
NKHLPIKVSD PSQPCDFHYE CECICSMWGG SHYSTFDGTS YTFRGNCTYV
5110 5120 5130 5140 5150
LMREIHARFG NLSLYLDNHY CTASATAAAA RCPRALSIHY KSMDIVLTVT
5160 5170 5180 5190 5200
MVHGKEEGLI LFDQIPVSSG FSKNGVLVSV LGTTTMRVDI PALGVSVTFN
5210 5220 5230 5240 5250
GQVFQARLPY SLFHNNTEGQ CGTCTNNQRD DCLQRDGTTA ASCKDMAKTW
5260 5270 5280 5290 5300
LVPDSRKDGC WAPTGTPPTA SPAAPVSSTP TPTPCPPQPL CDLMLSQVFA
5310 5320 5330 5340 5350
ECHNLVPPGP FFNACISDHC RGRLEVPCQS LEAYAELCRA RGVCSDWRGA
5360 5370 5380 5390 5400
TGGLCDLTCP PTKVYKPCGP IQPATCNSRN QSPQLEGMAE GCFCPEDQIL
5410 5420 5430 5440 5450
FNAHMGICVQ ACPCVGPDGF PKFPGERWVS NCQSCVCDEG SVSVQCKPLP
5460 5470 5480 5490 5500
CDAQGQPPPC NRPGFVTVTR PRAENPCCPE TVCVCNTTTC PQSLPVCPPG
5510 5520 5530 5540 5550
QESICTQEEG DCCPTFRCRP QLCSYNGTFY GVGATFPGAL PCHMCTCLSG
5560 5570 5580 5590 5600
DTQDPTVQCQ EDACNNTTCP QGFEYKRVAG QCCGECVQTA CLTPDGQPVQ
5610 5620 5630 5640 5650
LNETWVNSHV DNCTVYLCEA EGGVHLLTPQ PASCPDVSSC RGSLRKTGCC
5660 5670 5680 5690 5700
YSCEEDSCQV RINTTILWHQ GCETEVNITF CEGSCPGASK YSAEAQAMQH
5710 5720 5730 5740 5750
QCTCCQERRV HEETVPLHCP NGSAILHTYT HVDECGCTPF CVPAPMAPPH
5760
TRGFPAQEAT AV
Length:5,762
Mass (Da):596,340
Last modified:October 5, 2010 - v3
Checksum:i1FEC7CDCD0ADA81C
GO

Sequence cautioni

The sequence CAA06167.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 1006FPGLCN → LPCLCK in AAC67545. (PubMed:9790959)Curated
Sequence conflicti104 – 1041S → C in AAC67545. (PubMed:9790959)Curated
Sequence conflicti142 – 1421E → K in AAG33673. (PubMed:11713095)Curated
Sequence conflicti225 – 2251R → S in AAC67545. (PubMed:9790959)Curated
Sequence conflicti330 – 3312PL → T in AAC67545. (PubMed:9790959)Curated
Sequence conflicti337 – 3371E → N in AAC67545. (PubMed:9790959)Curated
Sequence conflicti356 – 3561E → K in AAC67545. (PubMed:9790959)Curated
Sequence conflicti362 – 3621G → R in AAC67545. (PubMed:9790959)Curated
Sequence conflicti368 – 3681G → GS in AAG33673. (PubMed:11713095)Curated
Sequence conflicti373 – 3731D → N in AAC67545. (PubMed:9790959)Curated
Sequence conflicti392 – 3932RT → TR in AAC67545. (PubMed:9790959)Curated
Sequence conflicti467 – 4682RK → GR in AAC67545. (PubMed:9790959)Curated
Sequence conflicti511 – 5111L → P in AAC67545. (PubMed:9790959)Curated
Sequence conflicti584 – 5863GAA → AH in CAA06167. (PubMed:9804771)Curated
Sequence conflicti600 – 6001A → S in CAA06167. (PubMed:9804771)Curated
Sequence conflicti627 – 6282DP → RS in AAC67545. (PubMed:9790959)Curated
Sequence conflicti632 – 6321F → L in AAC67545. (PubMed:9790959)Curated
Sequence conflicti675 – 6751A → P in CAA06167. (PubMed:9804771)Curated
Sequence conflicti700 – 7001R → P in CAA06167. (PubMed:9804771)Curated
Sequence conflicti751 – 7511E → K in AAC67545. (PubMed:9790959)Curated
Sequence conflicti811 – 8111P → L in AAC67545. (PubMed:9790959)Curated
Sequence conflicti816 – 8172LR → DG in AAC67545. (PubMed:9790959)Curated
Sequence conflicti859 – 8602HN → NK in AAC67545. (PubMed:9790959)Curated
Sequence conflicti866 – 8661P → L in AAC67545. (PubMed:9790959)Curated
Sequence conflicti872 – 8721V → F in AAC67545. (PubMed:9790959)Curated
Sequence conflicti883 – 8831R → T in AAC67545. (PubMed:9790959)Curated
Sequence conflicti889 – 8891R → G in CAA06167. (PubMed:9804771)Curated
Sequence conflicti1020 – 10201G → A in AAC67545. (PubMed:9790959)Curated
Sequence conflicti1082 – 10821Q → E in AAC67545. (PubMed:9790959)Curated
Sequence conflicti1144 – 11441S → C in CAA06167. (PubMed:9804771)Curated
Sequence conflicti1195 – 11951G → R in AAC67545. (PubMed:9790959)Curated
Sequence conflicti1207 – 12071Missing in AAC67545. (PubMed:9790959)Curated
Sequence conflicti1291 – 12911S → T in CAA06167. (PubMed:9804771)Curated
Sequence conflicti1317 – 13171Missing in AAC67545. (PubMed:9790959)Curated
Sequence conflicti1675 – 16773TTP → RQS in CAA96577. (PubMed:9013550)Curated
Sequence conflicti1926 – 19272PT → AS in CAA96577. (PubMed:9013550)Curated
Sequence conflicti1930 – 19312LR → QA in CAA96577. (PubMed:9013550)Curated
Sequence conflicti1934 – 19407PPPKVLT → GTPHVS in CAA96577. (PubMed:9013550)Curated
Sequence conflicti1956 – 19561S → F in CAA96577. (PubMed:9013550)Curated
Sequence conflicti1980 – 19823VTP → FTA in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2002 – 20021T → M in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2017 – 20171A → V in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2052 – 20521P → L in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2069 – 20735TALTP → RARTL in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2102 – 21021A → P in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2174 – 21741N → S in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2203 – 22031P → S in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2211 – 22111R → C in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2233 – 22331V → G in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2300 – 23001S → Q in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2333 – 23331P → S in AAB61398. (PubMed:9147051)Curated
Sequence conflicti2456 – 249742SSTPG…TPHVS → TSTLRTAPPPKVLT in CAA96577. (PubMed:9013550)CuratedAdd
BLAST
Sequence conflicti2461 – 24622TT → DD in AAB61398. (PubMed:9147051)Curated
Sequence conflicti2468 – 36951228Missing in AAB61398. (PubMed:9147051)CuratedAdd
BLAST
Sequence conflicti2513 – 25131F → S in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2537 – 25393FTA → VTP in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2574 – 25741V → A in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2582 – 25821T → A in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2609 – 26091L → P in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2628 – 26303RTL → LTP in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2659 – 26591P → A in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2713 – 27131T → R in CAA96577. (PubMed:9013550)Curated
Sequence conflicti2834 – 28341R → T in CAA96577. (PubMed:9013550)Curated
Sequence conflicti3028 – 30281T → Q in CAA96577. (PubMed:9013550)Curated
Sequence conflicti3080 – 30867LPEQTTT → SQNRPPH in CAA96577. (PubMed:9013550)Curated
Sequence conflicti3148 – 31525TGPTA → LPHG in CAA96577. (PubMed:9013550)Curated
Sequence conflicti3289 – 32891Missing in CAA96577. (PubMed:9013550)Curated
Sequence conflicti3490 – 34901V → G in CAA96577. (PubMed:9013550)Curated
Sequence conflicti3500 – 35001S → G in CAA96577. (PubMed:9013550)Curated
Sequence conflicti3504 – 35041H → P in CAA96577. (PubMed:9013550)Curated
Sequence conflicti3716 – 374732PGTTW…STQAT → QGPP in CAA96577. (PubMed:9013550)CuratedAdd
BLAST
Sequence conflicti3811 – 38111Q → P in AAB61398. (PubMed:9147051)Curated
Sequence conflicti3831 – 38311A → V in CAA96577. (PubMed:9013550)Curated
Sequence conflicti3845 – 38451R → G in CAA96577. (PubMed:9013550)Curated
Sequence conflicti3909 – 39091V → I in CAA96577. (PubMed:9013550)Curated
Sequence conflicti3924 – 39252TT → QP in CAA96577. (PubMed:9013550)Curated
Sequence conflicti3975 – 39751V → E in CAA96577. (PubMed:9013550)Curated
Sequence conflicti4060 – 40612QH → TT in CAA96577. (PubMed:9013550)Curated
Sequence conflicti4114 – 41141S → Q in CAA96577. (PubMed:9013550)Curated
Sequence conflicti4177 – 41771Q → T in CAA96577. (PubMed:9013550)Curated
Sequence conflicti4313 – 43131S → T in CAA52910. (PubMed:9013550)Curated
Sequence conflicti4373 – 43731Missing in CAA96577. (PubMed:9013550)Curated
Sequence conflicti4461 – 44633VPT → APP in CAA96577. (PubMed:9013550)Curated
Sequence conflicti4567 – 45671A → T in CAA96577. (PubMed:9013550)Curated
Sequence conflicti4780 – 47801T → P in AAC51344. (PubMed:9164870)Curated
Sequence conflicti5134 – 51341R → A in AAB65151. (PubMed:8554565)Curated
Sequence conflicti5164 – 51641Q → P in AAB65151. (PubMed:8554565)Curated
Sequence conflicti5187 – 51871R → A in AAC51344. (PubMed:9164870)Curated
Sequence conflicti5187 – 51871R → A in AAB65151. (PubMed:8554565)Curated
Sequence conflicti5289 – 52891P → L in AAB65151. (PubMed:8554565)Curated
Sequence conflicti5304 – 53063NLV → TLL in AAB65151. (PubMed:8554565)Curated
Sequence conflicti5333 – 53331A → R in AAC51344. (PubMed:9164870)Curated
Sequence conflicti5397 – 53971D → N in AAC51343. (PubMed:9164870)Curated
Sequence conflicti5397 – 53971D → N in AAC51344. (PubMed:9164870)Curated
Sequence conflicti5474 – 54741E → R in CAA70926. (PubMed:9201995)Curated
Sequence conflicti5475 – 54751N → T in AAB65151. (PubMed:8554565)Curated
Sequence conflicti5620 – 56201A → S in AAB65151. (PubMed:8554565)Curated
Sequence conflicti5632 – 56321A → D in AAC51343. (PubMed:9164870)Curated
Sequence conflicti5660 – 56601V → C in AAB65151. (PubMed:8554565)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341E → G.2 Publications
Corresponds to variant rs2672785 [ dbSNP | Ensembl ].
VAR_063616
Natural varianti51 – 511R → W.
Corresponds to variant rs2075853 [ dbSNP | Ensembl ].
VAR_056588
Natural varianti1360 – 13601T → M.
Corresponds to variant rs12363494 [ dbSNP | Ensembl ].
VAR_059538
Natural varianti1401 – 14011R → H.
Corresponds to variant rs10835639 [ dbSNP | Ensembl ].
VAR_059539
Natural varianti1805 – 18051G → S.1 Publication
Corresponds to variant rs1541314 [ dbSNP | Ensembl ].
VAR_063617
Natural varianti1889 – 18891P → L.1 Publication
Corresponds to variant rs2943510 [ dbSNP | Ensembl ].
VAR_063618
Natural varianti2025 – 20251A → T.1 Publication
Corresponds to variant rs34739266 [ dbSNP | Ensembl ].
VAR_063619
Natural varianti2027 – 20271A → T.
Corresponds to variant rs2943531 [ dbSNP | Ensembl ].
VAR_059540
Natural varianti2194 – 21941M → T.1 Publication
Corresponds to variant rs2943502 [ dbSNP | Ensembl ].
VAR_063620
Natural varianti2238 – 22381L → P.1 Publication
Corresponds to variant rs4963031 [ dbSNP | Ensembl ].
VAR_063621
Natural varianti2425 – 24251M → T.1 Publication
Corresponds to variant rs3965632 [ dbSNP | Ensembl ].
VAR_063622
Natural varianti2559 – 25591T → M.
Corresponds to variant rs2860722 [ dbSNP | Ensembl ].
VAR_059541
Natural varianti3072 – 30721F → S.1 Publication
Corresponds to variant rs3021161 [ dbSNP | Ensembl ].
VAR_063623
Natural varianti3284 – 32841T → A.1 Publication
Corresponds to variant rs2943531 [ dbSNP | Ensembl ].
VAR_063624
Natural varianti3468 – 34681R → P.1 Publication
Corresponds to variant rs2943529 [ dbSNP | Ensembl ].
VAR_063625
Natural varianti3816 – 38161T → M.1 Publication
Corresponds to variant rs75917341 [ dbSNP | Ensembl ].
VAR_063626
Natural varianti4404 – 44041A → G.1 Publication
Corresponds to variant rs2943517 [ dbSNP | Ensembl ].
VAR_063627
Natural varianti4440 – 44401P → L.1 Publication
Corresponds to variant rs2943516 [ dbSNP | Ensembl ].
VAR_063628
Natural varianti4706 – 47061T → P.1 Publication
Corresponds to variant rs2943512 [ dbSNP | Ensembl ].
VAR_063629
Natural varianti4712 – 47121T → M.1 Publication
Corresponds to variant rs2943511 [ dbSNP | Ensembl ].
VAR_063630
Natural varianti4867 – 48671A → T.1 Publication
Corresponds to variant rs3021155 [ dbSNP | Ensembl ].
VAR_063631
Natural varianti4882 – 48821T → A.1 Publication
Corresponds to variant rs3021156 [ dbSNP | Ensembl ].
VAR_063632
Natural varianti5196 – 51961S → T.1 Publication
Corresponds to variant rs2672788 [ dbSNP | Ensembl ].
VAR_014123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107890 Genomic DNA. Translation: AAG33673.1.
AF086604 mRNA. Translation: AAC67545.1.
AJ004862 Genomic DNA. Translation: CAA06167.1. Different initiation.
X74955 mRNA. Translation: CAA52910.1.
Z72496 Genomic DNA. Translation: CAA96577.1.
U63836 mRNA. Translation: AAB61398.1.
U78551 mRNA. Translation: AAC51343.1.
AH006676 Genomic DNA. Translation: AAC51344.1.
U95031 mRNA. Translation: AAB65151.1.
Y09788 Genomic DNA. Translation: CAA70926.1.
CCDSiCCDS44515.2.
PIRiA33811.
T45025.
RefSeqiNP_002449.2. NM_002458.2.
UniGeneiHs.523395.

Genome annotation databases

EnsembliENST00000529681; ENSP00000436812; ENSG00000117983.
GeneIDi727897.
KEGGihsa:727897.
UCSCiuc001lta.3. human.

Polymorphism databases

DMDMi308153579.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107890 Genomic DNA. Translation: AAG33673.1 .
AF086604 mRNA. Translation: AAC67545.1 .
AJ004862 Genomic DNA. Translation: CAA06167.1 . Different initiation.
X74955 mRNA. Translation: CAA52910.1 .
Z72496 Genomic DNA. Translation: CAA96577.1 .
U63836 mRNA. Translation: AAB61398.1 .
U78551 mRNA. Translation: AAC51343.1 .
AH006676 Genomic DNA. Translation: AAC51344.1 .
U95031 mRNA. Translation: AAB65151.1 .
Y09788 Genomic DNA. Translation: CAA70926.1 .
CCDSi CCDS44515.2.
PIRi A33811.
T45025.
RefSeqi NP_002449.2. NM_002458.2.
UniGenei Hs.523395.

3D structure databases

ProteinModelPortali Q9HC84.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 608337. 7 interactions.

Protein family/group databases

MEROPSi I08.953.

PTM databases

PhosphoSitei Q9HC84.

Polymorphism databases

DMDMi 308153579.

Proteomic databases

MaxQBi Q9HC84.
PaxDbi Q9HC84.
PRIDEi Q9HC84.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000529681 ; ENSP00000436812 ; ENSG00000117983 .
GeneIDi 727897.
KEGGi hsa:727897.
UCSCi uc001lta.3. human.

Organism-specific databases

CTDi 727897.
GeneCardsi GC11P001244.
H-InvDB HIX0035863.
HIX0171268.
HIX0171346.
HGNCi HGNC:7516. MUC5B.
HPAi CAB009396.
HPA008246.
MIMi 178500. phenotype.
600770. gene.
neXtProti NX_Q9HC84.
Orphaneti 171700. Diffuse panbronchiolitis.
2032. Idiopathic pulmonary fibrosis.
PharmGKBi PA31321.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118896.
HOVERGENi HBG052535.
InParanoidi Q9HC84.
KOi K13908.
TreeFami TF300299.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSi MUC5B. human.
GeneWikii MUC5B.
GenomeRNAii 727897.
NextBioi 125477.
PROi Q9HC84.
SOURCEi Search...

Gene expression databases

Bgeei Q9HC84.
ExpressionAtlasi Q9HC84. baseline and differential.
Genevestigatori Q9HC84.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view ]
Pfami PF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 7 hits.
PF01826. TIL. 3 hits.
PF00093. VWC. 1 hit.
PF00094. VWD. 4 hits.
[Graphical view ]
SMARTi SM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 3 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 4 hits.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 4 hits.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region."
    Chen Y., Zhao Y.H., Di Y.P., Wu R.
    Am. J. Respir. Cell Mol. Biol. 25:542-553(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1593, INDUCTION, TISSUE SPECIFICITY, VARIANT GLY-34.
  2. "The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions."
    Offner G.D., Nunes D.P., Keates A.C., Afdhal N.H., Troxler R.F.
    Biochem. Biophys. Res. Commun. 251:350-355(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1324.
  3. "Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon."
    Desseyn J.-L., Buisine M.P., Porchet N., Aubert J.-P., Laine A.
    J. Biol. Chem. 273:30157-30164(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-1323, VARIANT GLY-34.
  4. "Human mucin gene MUC5B, the 10.7 kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family."
    Desseyn J.-L., Guyonnet-Duperat V., Porchet N., Aubert J.-P., Laine A.
    J. Biol. Chem. 272:3168-3178(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1325-4954, NUCLEOTIDE SEQUENCE [MRNA] OF 4170-4791, VARIANTS SER-1805; LEU-1889; THR-2025; THR-2194; PRO-2238; THR-2425; SER-3072; ALA-3284; PRO-3468; MET-3816; GLY-4404; LEU-4440; PRO-4706; MET-4712; THR-4867 AND ALA-4882.
    Tissue: Placenta and Tracheobronchial mucosa.
  5. "Proteolytic fragmentation and peptide mapping of human carboxyamidomethylated tracheobronchial mucin."
    Rose M.C., Kaufman B., Martin B.M.
    J. Biol. Chem. 264:8193-8199(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2346-2358; 2903-2915; 3603-3615 AND 4160-4172.
    Tissue: Tracheobronchial mucosa.
  6. "Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B."
    Nielsen P.A., Bennett E.P., Wandall H.H., Therkildsen M.H., Hannibal J., Clausen H.
    Glycobiology 7:413-419(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2301-3811, TISSUE SPECIFICITY.
    Tissue: Salivary gland.
  7. "Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B."
    Keates A.C., Nunes D.P., Afdhal N.H., Troxler R.F., Offner G.D.
    Biochem. J. 324:295-303(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4780-5423, NUCLEOTIDE SEQUENCE [MRNA] OF 5373-5762, TISSUE SPECIFICITY.
    Tissue: Gall bladder.
  8. "Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland."
    Troxler R.F., Offner G.D., Zhang F., Iontcheva I., Oppenheim F.G.
    Biochem. Biophys. Res. Commun. 217:1112-1119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4868-5746, TISSUE SPECIFICITY.
    Tissue: Sublingual gland.
  9. "Genomic organization of the 3 region of the human MUC5B mucin."
    Desseyn J.-L., Aubert J.-P., Porchet N., Laine A.
    J. Biol. Chem. 272:16873-16883(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4918-5762, VARIANT THR-5196.
    Tissue: Placenta.
  10. Cited for: STRUCTURE OF O-LINKED CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
  11. "C-Mannosylation of MUC5AC and MUC5B Cys subdomains."
    Perez-Vilar J., Randell S.H., Boucher R.C.
    Glycobiology 14:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, MUTAGENESIS OF TRP-1790.
  12. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145; ASN-254; ASN-1556; ASN-4960; ASN-5017; ASN-5024; ASN-5046; ASN-5096; ASN-5111 AND ASN-5215.
    Tissue: Saliva.
  13. Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO IPF.
  14. "A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis."
    Zhang Y., Noth I., Garcia J.G., Kaminski N.
    N. Engl. J. Med. 364:1576-1577(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO IPF.

Entry informationi

Entry nameiMUC5B_HUMAN
AccessioniPrimary (citable) accession number: Q9HC84
Secondary accession number(s): O00447
, O00573, O14985, O15494, O95291, O95451, Q14881, Q7M4S5, Q99552, Q9UE28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 5, 2010
Last modified: November 26, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3