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Q9HC78 (ZBT20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger and BTB domain-containing protein 20
Alternative name(s):
Dendritic-derived BTB/POZ zinc finger protein
Zinc finger protein 288
Gene names
Name:ZBTB20
Synonyms:DPZF, ZNF288
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length741 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses. Ref.1

Subunit structure

Can homodimerize. Binds to DNA.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in spleen, lymph node, thymus, peripheral blood leukocytes, and fetal liver. Ref.1

Post-translational modification

Sumoylated with SUMO1 By similarity.

Sequence similarities

Contains 1 BTB (POZ) domain.

Contains 5 C2H2-type zinc fingers.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9HC78-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HC78-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 741741Zinc finger and BTB domain-containing protein 20
PRO_0000047733

Regions

Domain104 – 16764BTB
Zinc finger578 – 60023C2H2-type 1
Zinc finger606 – 62823C2H2-type 2
Zinc finger634 – 65623C2H2-type 3
Zinc finger662 – 68423C2H2-type 4
Zinc finger715 – 73723C2H2-type 5

Amino acid modifications

Modified residue4651Phosphoserine Ref.6
Modified residue4721Phosphoserine Ref.6

Natural variations

Alternative sequence1 – 7373Missing in isoform 2.
VSP_032503

Experimental info

Sequence conflict2241S → G in AAG28340. Ref.1
Sequence conflict2661V → M in AAG28340. Ref.1
Sequence conflict3321E → G in CAH56190. Ref.3
Sequence conflict3371Y → F in AAG28340. Ref.1
Sequence conflict4651S → F in AAG28340. Ref.1
Sequence conflict5171A → V in AAG28340. Ref.1
Sequence conflict5431S → F in AAH29041. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 18, 2008. Version 3.
Checksum: 913DDA9E6771C1EF

FASTA74181,083
        10         20         30         40         50         60 
MLERKKPKTA ENQKASEENE ITQPGGSSAK PGLPCLNFEA VLSPDPALIH STHSLTNSHA 

        70         80         90        100        110        120 
HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR GHFCDVTVRI HGSMLRAHRC 

       130        140        150        160        170        180 
VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS VQKLIDFMYS GVLRVSQSEA LQILTAASIL 

       190        200        210        220        230        240 
QIKTVIDECT RIVSQNVGDV FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV 

       250        260        270        280        290        300 
DRIYSALYAC SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER 

       310        320        330        340        350        360 
YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER NESEECTEDT 

       370        380        390        400        410        420 
DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGPGAAR DSQAEPTQPE QAAEAPAEGG 

       430        440        450        460        470        480 
PQTNQLETGA SSPERSNEVE MDSTVITVSN SSDKSVLQQP SVNTSIGQPL PSTQLYLRQT 

       490        500        510        520        530        540 
ETLTSNLRMP LTLTSNTQVI GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLAGQQTQFV 

       550        560        570        580        590        600 
TVSQPGLSTF TAQLPAPQPL ASSAGHSTAS GQGEKKPYEC TLCNKTFTAK QNYVKHMFVH 

       610        620        630        640        650        660 
TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN VHMRLHRGEK 

       670        680        690        700        710        720 
SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR AGPPGVVACT EGTTYVCSVC 

       730        740 
PAKFDQIEQF NDHMRMHVSD G 

« Hide

Isoform 2 [UniParc].

Checksum: F280249454E57C62
Show »

FASTA66873,401

References

« Hide 'large scale' references
[1]"Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6."
Zhang W., Mi J., Li N., Sui L., Wan T., Zhang J., Chen T., Cao X.
Biochem. Biophys. Res. Commun. 282:1067-1073(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Kidney.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Endometrium.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Colon.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND SER-472, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[7]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF139460 mRNA. Translation: AAG28340.2.
AL050276 mRNA. Translation: CAB43377.1.
BX647778 mRNA. Translation: CAH56190.1.
CH471052 Genomic DNA. Translation: EAW79598.1.
BC029041 mRNA. Translation: AAH29041.1.
CCDSCCDS2981.1. [Q9HC78-2]
CCDS54626.1. [Q9HC78-1]
PIRT08725.
RefSeqNP_001157814.1. NM_001164342.1. [Q9HC78-1]
NP_001157815.1. NM_001164343.1. [Q9HC78-2]
NP_001157816.1. NM_001164344.1. [Q9HC78-2]
NP_001157817.1. NM_001164345.1. [Q9HC78-2]
NP_001157818.1. NM_001164346.1. [Q9HC78-2]
NP_001157819.1. NM_001164347.1. [Q9HC78-2]
NP_056457.3. NM_015642.4. [Q9HC78-2]
XP_005247396.1. XM_005247339.1. [Q9HC78-1]
XP_005247397.1. XM_005247340.1. [Q9HC78-1]
XP_005247398.1. XM_005247341.1. [Q9HC78-1]
XP_005247399.1. XM_005247342.1. [Q9HC78-2]
XP_005247400.1. XM_005247343.1. [Q9HC78-2]
XP_006713640.1. XM_006713577.1. [Q9HC78-1]
XP_006713641.1. XM_006713578.1. [Q9HC78-1]
XP_006713643.1. XM_006713580.1. [Q9HC78-2]
XP_006713644.1. XM_006713581.1. [Q9HC78-2]
UniGeneHs.202577.
Hs.592414.
Hs.655108.
Hs.732516.
Hs.744879.

3D structure databases

ProteinModelPortalQ9HC78.
SMRQ9HC78. Positions 81-190, 528-737.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117573. 5 interactions.
IntActQ9HC78. 2 interactions.
MINTMINT-2823546.
STRING9606.ENSP00000349803.

PTM databases

PhosphoSiteQ9HC78.

Polymorphism databases

DMDM172045933.

Proteomic databases

MaxQBQ9HC78.
PaxDbQ9HC78.
PRIDEQ9HC78.

Protocols and materials databases

DNASU26137.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357258; ENSP00000349803; ENSG00000181722. [Q9HC78-2]
ENST00000393785; ENSP00000377375; ENSG00000181722. [Q9HC78-2]
ENST00000462705; ENSP00000420324; ENSG00000181722. [Q9HC78-2]
ENST00000464560; ENSP00000417307; ENSG00000181722. [Q9HC78-2]
ENST00000471418; ENSP00000419902; ENSG00000181722. [Q9HC78-2]
ENST00000474710; ENSP00000419153; ENSG00000181722. [Q9HC78-1]
ENST00000481632; ENSP00000418092; ENSG00000181722. [Q9HC78-2]
GeneID26137.
KEGGhsa:26137.
UCSCuc003ebi.3. human. [Q9HC78-1]

Organism-specific databases

CTD26137.
GeneCardsGC03M114056.
HGNCHGNC:13503. ZBTB20.
HPAHPA015551.
HPA016815.
MIM606025. gene.
neXtProtNX_Q9HC78.
PharmGKBPA37789.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000136747.
HOVERGENHBG060183.
InParanoidQ9HC78.
KOK10501.
OMAQIEHFND.
OrthoDBEOG7GQXV7.
PhylomeDBQ9HC78.
TreeFamTF335684.

Gene expression databases

ArrayExpressQ9HC78.
BgeeQ9HC78.
CleanExHS_ZBTB20.
GenevestigatorQ9HC78.

Family and domain databases

Gene3D3.30.160.60. 4 hits.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZBTB20. human.
GeneWikiZBTB20.
GenomeRNAi26137.
NextBio48181.
PROQ9HC78.
SOURCESearch...

Entry information

Entry nameZBT20_HUMAN
AccessionPrimary (citable) accession number: Q9HC78
Secondary accession number(s): Q63HP6, Q8N6R5, Q9Y410
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 18, 2008
Last modified: July 9, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM