Q9HC78 (ZBT20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 20

Alternative name(s):
Dendritic-derived BTB/POZ zinc finger protein
Zinc finger protein 288

Gene names

Name:	ZBTB20
Synonyms:	DPZF, ZNF288

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	741 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses. Ref.1
Subunit structure	Can homodimerize. Binds to DNA.
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed in spleen, lymph node, thymus, peripheral blood leukocytes, and fetal liver. Ref.1
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: HPA
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HC78-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HC78-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 741	741	Zinc finger and BTB domain-containing protein 20		PRO_0000047733
Regions
	Domain	104 – 167	64	BTB
	Zinc finger	578 – 600	23	C2H2-type 1
	Zinc finger	606 – 628	23	C2H2-type 2
	Zinc finger	634 – 656	23	C2H2-type 3
	Zinc finger	662 – 684	23	C2H2-type 4
	Zinc finger	715 – 737	23	C2H2-type 5
Amino acid modifications
	Modified residue	432	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 73	73	Missing in isoform 2.		VSP_032503
Experimental info
	Sequence conflict	224	1	S → G in AAG28340. Ref.1
	Sequence conflict	266	1	V → M in AAG28340. Ref.1
	Sequence conflict	332	1	E → G in CAH56190. Ref.3
	Sequence conflict	337	1	Y → F in AAG28340. Ref.1
	Sequence conflict	465	1	S → F in AAG28340. Ref.1
	Sequence conflict	517	1	A → V in AAG28340. Ref.1
	Sequence conflict	543	1	S → F in AAH29041. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 18, 2008. Version 3. Checksum: 913DDA9E6771C1EF	FASTA	741	81,083
	10 20 30 40 50 60 MLERKKPKTA ENQKASEENE ITQPGGSSAK PGLPCLNFEA VLSPDPALIH STHSLTNSHA 70 80 90 100 110 120 HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR GHFCDVTVRI HGSMLRAHRC 130 140 150 160 170 180 VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS VQKLIDFMYS GVLRVSQSEA LQILTAASIL 190 200 210 220 230 240 QIKTVIDECT RIVSQNVGDV FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV 250 260 270 280 290 300 DRIYSALYAC SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER 310 320 330 340 350 360 YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER NESEECTEDT 370 380 390 400 410 420 DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGPGAAR DSQAEPTQPE QAAEAPAEGG 430 440 450 460 470 480 PQTNQLETGA SSPERSNEVE MDSTVITVSN SSDKSVLQQP SVNTSIGQPL PSTQLYLRQT 490 500 510 520 530 540 ETLTSNLRMP LTLTSNTQVI GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLAGQQTQFV 550 560 570 580 590 600 TVSQPGLSTF TAQLPAPQPL ASSAGHSTAS GQGEKKPYEC TLCNKTFTAK QNYVKHMFVH 610 620 630 640 650 660 TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN VHMRLHRGEK 670 680 690 700 710 720 SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR AGPPGVVACT EGTTYVCSVC 730 740 PAKFDQIEQF NDHMRMHVSD G
	Isoform 2 [UniParc]. Checksum: F280249454E57C62	FASTA	668	73,401
	10 20 30 40 50 60 MTERIHSINL HNFSNSVLET LNEQRNRGHF CDVTVRIHGS MLRAHRCVLA AGSPFFQDKL 70 80 90 100 110 120 LLGYSDIEIP SVVSVQSVQK LIDFMYSGVL RVSQSEALQI LTAASILQIK TVIDECTRIV 130 140 150 160 170 180 SQNVGDVFPG IQDSGQDTPR GTPESGTSGQ SSDTESGYLQ SHPQHSVDRI YSALYACSMQ 190 200 210 220 230 240 NGSGERSFYS GAVVSHHETA LGLPRDHHME DPSWITRIHE RSQQMERYLS TTPETTHCRK 250 260 270 280 290 300 QPRPVRIQTL VGNIHIKQEM EDDYDYYGQQ RVQILERNES EECTEDTDQA EGTESEPKGE 310 320 330 340 350 360 SFDSGVSSSI GTEPDSVEQQ FGPGAARDSQ AEPTQPEQAA EAPAEGGPQT NQLETGASSP 370 380 390 400 410 420 ERSNEVEMDS TVITVSNSSD KSVLQQPSVN TSIGQPLPST QLYLRQTETL TSNLRMPLTL 430 440 450 460 470 480 TSNTQVIGTA GNTYLPALFT TQPAGSGPKP FLFSLPQPLA GQQTQFVTVS QPGLSTFTAQ 490 500 510 520 530 540 LPAPQPLASS AGHSTASGQG EKKPYECTLC NKTFTAKQNY VKHMFVHTGE KPHQCSICWR 550 560 570 580 590 600 SFSLKDYLIK HMVTHTGVRA YQCSICNKRF TQKSSLNVHM RLHRGEKSYE CYICKKKFSH 610 620 630 640 650 660 KTLLERHVAL HSASNGTPPA GTPPGARAGP PGVVACTEGT TYVCSVCPAK FDQIEQFNDH MRMHVSDG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6." Zhang W., Mi J., Li N., Sui L., Wan T., Zhang J., Chen T., Cao X. Biochem. Biophys. Res. Commun. 282:1067-1073(2001) [PubMed: 11352661] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Kidney.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Endometrium.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF139460 mRNA. Translation: AAG28340.2. AL050276 mRNA. Translation: CAB43377.1. BX647778 mRNA. Translation: CAH56190.1. CH471052 Genomic DNA. Translation: EAW79598.1. BC029041 mRNA. Translation: AAH29041.1.
IPI	IPI00178894. IPI00743178.
PIR	T08725.
RefSeq	NP_001157814.1. NM_001164342.1. NP_001157815.1. NM_001164343.1. NP_001157816.1. NM_001164344.1. NP_001157817.1. NM_001164345.1. NP_001157818.1. NM_001164346.1. NP_001157819.1. NM_001164347.1. NP_056457.3. NM_015642.4.
UniGene	Hs.655108.
3D structure databases
ProteinModelPortal	Q9HC78.
SMR	Q9HC78. Positions 77-195, 527-739.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9HC78.
PTM databases
PhosphoSite	Q9HC78.
Polymorphism databases
DMDM	172045933.
Proteomic databases
PRIDE	Q9HC78.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000393785; ENSP00000377375; ENSG00000181722. ENST00000474710; ENSP00000419153; ENSG00000181722.
GeneID	26137.
KEGG	hsa:26137.
UCSC	uc003ebi.1. human. uc003ebj.1. human.
Organism-specific databases
CTD	26137.
GeneCards	GC03M114056.
HGNC	HGNC:13503. ZBTB20.
HPA	HPA016815.
MIM	606025. gene.
neXtProt	NX_Q9HC78.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16319.
GeneTree	ENSGT00580000081504.
HOGENOM	HBG714316.
HOVERGEN	HBG060183.
InParanoid	Q9HC78.
OMA	PPGVVAC.
PhylomeDB	Q9HC78.
Gene expression databases
ArrayExpress	Q9HC78.
Bgee	Q9HC78.
CleanEx	HS_ZBTB20.
Genevestigator	Q9HC78.
GermOnline	ENSG00000181722. Homo sapiens.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 4 hits.
KO	K10501.
Pfam	PF00651. BTB. 1 hit. PF00096. zf-C2H2. 4 hits. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 5 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 5 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	48181.
SOURCE	Search...

Entry information

Entry name

ZBT20_HUMAN

Accession

Primary (citable) accession number: Q9HC78
Secondary accession number(s): Q63HP6, Q8N6R5, Q9Y410

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	March 18, 2008
Last modified:	January 25, 2012
This is version 96 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.