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Q9HC78

- ZBT20_HUMAN

UniProt

Q9HC78 - ZBT20_HUMAN

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Protein

Zinc finger and BTB domain-containing protein 20

Gene

ZBTB20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri578 – 60023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 62823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri634 – 65623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri715 – 73723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 20
Alternative name(s):
Dendritic-derived BTB/POZ zinc finger protein
Zinc finger protein 288
Gene namesi
Name:ZBTB20
Synonyms:DPZF, ZNF288
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:13503. ZBTB20.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37789.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 741741Zinc finger and BTB domain-containing protein 20PRO_0000047733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei465 – 4651Phosphoserine1 Publication
Modified residuei472 – 4721Phosphoserine1 Publication

Post-translational modificationi

Sumoylated with SUMO1.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9HC78.
PaxDbiQ9HC78.
PRIDEiQ9HC78.

PTM databases

PhosphoSiteiQ9HC78.

Expressioni

Tissue specificityi

Expressed in spleen, lymph node, thymus, peripheral blood leukocytes, and fetal liver.1 Publication

Gene expression databases

BgeeiQ9HC78.
CleanExiHS_ZBTB20.
ExpressionAtlasiQ9HC78. baseline and differential.
GenevestigatoriQ9HC78.

Organism-specific databases

HPAiHPA015551.
HPA016815.

Interactioni

Subunit structurei

Can homodimerize. Binds to DNA.

Protein-protein interaction databases

BioGridi117573. 5 interactions.
IntActiQ9HC78. 2 interactions.
MINTiMINT-2823546.
STRINGi9606.ENSP00000349803.

Structurei

3D structure databases

ProteinModelPortaliQ9HC78.
SMRiQ9HC78. Positions 81-190, 569-737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 16764BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri578 – 60023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri606 – 62823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri634 – 65623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri715 – 73723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000136747.
HOVERGENiHBG060183.
InParanoidiQ9HC78.
KOiK10501.
OMAiQIEHFND.
OrthoDBiEOG7GQXV7.
PhylomeDBiQ9HC78.
TreeFamiTF335684.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HC78-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLERKKPKTA ENQKASEENE ITQPGGSSAK PGLPCLNFEA VLSPDPALIH
60 70 80 90 100
STHSLTNSHA HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR
110 120 130 140 150
GHFCDVTVRI HGSMLRAHRC VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS
160 170 180 190 200
VQKLIDFMYS GVLRVSQSEA LQILTAASIL QIKTVIDECT RIVSQNVGDV
210 220 230 240 250
FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV DRIYSALYAC
260 270 280 290 300
SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER
310 320 330 340 350
YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER
360 370 380 390 400
NESEECTEDT DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGPGAAR
410 420 430 440 450
DSQAEPTQPE QAAEAPAEGG PQTNQLETGA SSPERSNEVE MDSTVITVSN
460 470 480 490 500
SSDKSVLQQP SVNTSIGQPL PSTQLYLRQT ETLTSNLRMP LTLTSNTQVI
510 520 530 540 550
GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLAGQQTQFV TVSQPGLSTF
560 570 580 590 600
TAQLPAPQPL ASSAGHSTAS GQGEKKPYEC TLCNKTFTAK QNYVKHMFVH
610 620 630 640 650
TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN
660 670 680 690 700
VHMRLHRGEK SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR
710 720 730 740
AGPPGVVACT EGTTYVCSVC PAKFDQIEQF NDHMRMHVSD G
Length:741
Mass (Da):81,083
Last modified:March 18, 2008 - v3
Checksum:i913DDA9E6771C1EF
GO
Isoform 2 (identifier: Q9HC78-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:668
Mass (Da):73,401
Checksum:iF280249454E57C62
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti224 – 2241S → G in AAG28340. (PubMed:11352661)Curated
Sequence conflicti266 – 2661V → M in AAG28340. (PubMed:11352661)Curated
Sequence conflicti332 – 3321E → G in CAH56190. (PubMed:17974005)Curated
Sequence conflicti337 – 3371Y → F in AAG28340. (PubMed:11352661)Curated
Sequence conflicti465 – 4651S → F in AAG28340. (PubMed:11352661)Curated
Sequence conflicti517 – 5171A → V in AAG28340. (PubMed:11352661)Curated
Sequence conflicti543 – 5431S → F in AAH29041. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7373Missing in isoform 2. 3 PublicationsVSP_032503Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF139460 mRNA. Translation: AAG28340.2.
AL050276 mRNA. Translation: CAB43377.1.
BX647778 mRNA. Translation: CAH56190.1.
CH471052 Genomic DNA. Translation: EAW79598.1.
BC029041 mRNA. Translation: AAH29041.1.
CCDSiCCDS2981.1. [Q9HC78-2]
CCDS54626.1. [Q9HC78-1]
PIRiT08725.
RefSeqiNP_001157814.1. NM_001164342.2. [Q9HC78-1]
NP_001157815.1. NM_001164343.2. [Q9HC78-2]
NP_001157816.1. NM_001164344.2. [Q9HC78-2]
NP_001157817.1. NM_001164345.2. [Q9HC78-2]
NP_001157818.1. NM_001164346.2. [Q9HC78-2]
NP_001157819.1. NM_001164347.2. [Q9HC78-2]
NP_056457.3. NM_015642.5. [Q9HC78-2]
XP_005247396.1. XM_005247339.1. [Q9HC78-1]
XP_005247397.1. XM_005247340.1. [Q9HC78-1]
XP_005247398.1. XM_005247341.1. [Q9HC78-1]
XP_005247399.1. XM_005247342.1. [Q9HC78-2]
XP_005247400.1. XM_005247343.1. [Q9HC78-2]
XP_006713640.1. XM_006713577.1. [Q9HC78-1]
XP_006713641.1. XM_006713578.1. [Q9HC78-1]
XP_006713643.1. XM_006713580.1. [Q9HC78-2]
XP_006713644.1. XM_006713581.1. [Q9HC78-2]
UniGeneiHs.202577.
Hs.592414.
Hs.655108.
Hs.661491.
Hs.732516.
Hs.744879.

Genome annotation databases

EnsembliENST00000357258; ENSP00000349803; ENSG00000181722. [Q9HC78-2]
ENST00000393785; ENSP00000377375; ENSG00000181722. [Q9HC78-2]
ENST00000462705; ENSP00000420324; ENSG00000181722. [Q9HC78-2]
ENST00000464560; ENSP00000417307; ENSG00000181722. [Q9HC78-2]
ENST00000471418; ENSP00000419902; ENSG00000181722. [Q9HC78-2]
ENST00000474710; ENSP00000419153; ENSG00000181722. [Q9HC78-1]
ENST00000481632; ENSP00000418092; ENSG00000181722. [Q9HC78-2]
GeneIDi26137.
KEGGihsa:26137.
UCSCiuc003ebi.3. human. [Q9HC78-1]

Polymorphism databases

DMDMi172045933.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF139460 mRNA. Translation: AAG28340.2 .
AL050276 mRNA. Translation: CAB43377.1 .
BX647778 mRNA. Translation: CAH56190.1 .
CH471052 Genomic DNA. Translation: EAW79598.1 .
BC029041 mRNA. Translation: AAH29041.1 .
CCDSi CCDS2981.1. [Q9HC78-2 ]
CCDS54626.1. [Q9HC78-1 ]
PIRi T08725.
RefSeqi NP_001157814.1. NM_001164342.2. [Q9HC78-1 ]
NP_001157815.1. NM_001164343.2. [Q9HC78-2 ]
NP_001157816.1. NM_001164344.2. [Q9HC78-2 ]
NP_001157817.1. NM_001164345.2. [Q9HC78-2 ]
NP_001157818.1. NM_001164346.2. [Q9HC78-2 ]
NP_001157819.1. NM_001164347.2. [Q9HC78-2 ]
NP_056457.3. NM_015642.5. [Q9HC78-2 ]
XP_005247396.1. XM_005247339.1. [Q9HC78-1 ]
XP_005247397.1. XM_005247340.1. [Q9HC78-1 ]
XP_005247398.1. XM_005247341.1. [Q9HC78-1 ]
XP_005247399.1. XM_005247342.1. [Q9HC78-2 ]
XP_005247400.1. XM_005247343.1. [Q9HC78-2 ]
XP_006713640.1. XM_006713577.1. [Q9HC78-1 ]
XP_006713641.1. XM_006713578.1. [Q9HC78-1 ]
XP_006713643.1. XM_006713580.1. [Q9HC78-2 ]
XP_006713644.1. XM_006713581.1. [Q9HC78-2 ]
UniGenei Hs.202577.
Hs.592414.
Hs.655108.
Hs.661491.
Hs.732516.
Hs.744879.

3D structure databases

ProteinModelPortali Q9HC78.
SMRi Q9HC78. Positions 81-190, 569-737.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117573. 5 interactions.
IntActi Q9HC78. 2 interactions.
MINTi MINT-2823546.
STRINGi 9606.ENSP00000349803.

PTM databases

PhosphoSitei Q9HC78.

Polymorphism databases

DMDMi 172045933.

Proteomic databases

MaxQBi Q9HC78.
PaxDbi Q9HC78.
PRIDEi Q9HC78.

Protocols and materials databases

DNASUi 26137.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357258 ; ENSP00000349803 ; ENSG00000181722 . [Q9HC78-2 ]
ENST00000393785 ; ENSP00000377375 ; ENSG00000181722 . [Q9HC78-2 ]
ENST00000462705 ; ENSP00000420324 ; ENSG00000181722 . [Q9HC78-2 ]
ENST00000464560 ; ENSP00000417307 ; ENSG00000181722 . [Q9HC78-2 ]
ENST00000471418 ; ENSP00000419902 ; ENSG00000181722 . [Q9HC78-2 ]
ENST00000474710 ; ENSP00000419153 ; ENSG00000181722 . [Q9HC78-1 ]
ENST00000481632 ; ENSP00000418092 ; ENSG00000181722 . [Q9HC78-2 ]
GeneIDi 26137.
KEGGi hsa:26137.
UCSCi uc003ebi.3. human. [Q9HC78-1 ]

Organism-specific databases

CTDi 26137.
GeneCardsi GC03M114056.
HGNCi HGNC:13503. ZBTB20.
HPAi HPA015551.
HPA016815.
MIMi 606025. gene.
neXtProti NX_Q9HC78.
PharmGKBi PA37789.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119063.
HOGENOMi HOG000136747.
HOVERGENi HBG060183.
InParanoidi Q9HC78.
KOi K10501.
OMAi QIEHFND.
OrthoDBi EOG7GQXV7.
PhylomeDBi Q9HC78.
TreeFami TF335684.

Miscellaneous databases

ChiTaRSi ZBTB20. human.
GeneWikii ZBTB20.
GenomeRNAii 26137.
NextBioi 48181.
PROi Q9HC78.
SOURCEi Search...

Gene expression databases

Bgeei Q9HC78.
CleanExi HS_ZBTB20.
ExpressionAtlasi Q9HC78. baseline and differential.
Genevestigatori Q9HC78.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6."
    Zhang W., Mi J., Li N., Sui L., Wan T., Zhang J., Chen T., Cao X.
    Biochem. Biophys. Res. Commun. 282:1067-1073(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Endometrium.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND SER-472, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiZBT20_HUMAN
AccessioniPrimary (citable) accession number: Q9HC78
Secondary accession number(s): Q63HP6, Q8N6R5, Q9Y410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 18, 2008
Last modified: October 29, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3