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Q9HC78

- ZBT20_HUMAN

UniProt

Q9HC78 - ZBT20_HUMAN

Protein

Zinc finger and BTB domain-containing protein 20

Gene

ZBTB20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri578 – 60023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri606 – 62823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri634 – 65623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri662 – 68423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri715 – 73723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and BTB domain-containing protein 20
    Alternative name(s):
    Dendritic-derived BTB/POZ zinc finger protein
    Zinc finger protein 288
    Gene namesi
    Name:ZBTB20
    Synonyms:DPZF, ZNF288
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:13503. ZBTB20.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37789.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 741741Zinc finger and BTB domain-containing protein 20PRO_0000047733Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei465 – 4651Phosphoserine1 Publication
    Modified residuei472 – 4721Phosphoserine1 Publication

    Post-translational modificationi

    Sumoylated with SUMO1.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ9HC78.
    PaxDbiQ9HC78.
    PRIDEiQ9HC78.

    PTM databases

    PhosphoSiteiQ9HC78.

    Expressioni

    Tissue specificityi

    Expressed in spleen, lymph node, thymus, peripheral blood leukocytes, and fetal liver.1 Publication

    Gene expression databases

    ArrayExpressiQ9HC78.
    BgeeiQ9HC78.
    CleanExiHS_ZBTB20.
    GenevestigatoriQ9HC78.

    Organism-specific databases

    HPAiHPA015551.
    HPA016815.

    Interactioni

    Subunit structurei

    Can homodimerize. Binds to DNA.

    Protein-protein interaction databases

    BioGridi117573. 5 interactions.
    IntActiQ9HC78. 2 interactions.
    MINTiMINT-2823546.
    STRINGi9606.ENSP00000349803.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HC78.
    SMRiQ9HC78. Positions 81-190, 528-737.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini104 – 16764BTBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri578 – 60023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri606 – 62823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri634 – 65623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri662 – 68423C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri715 – 73723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000136747.
    HOVERGENiHBG060183.
    InParanoidiQ9HC78.
    KOiK10501.
    OMAiQIEHFND.
    OrthoDBiEOG7GQXV7.
    PhylomeDBiQ9HC78.
    TreeFamiTF335684.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HC78-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLERKKPKTA ENQKASEENE ITQPGGSSAK PGLPCLNFEA VLSPDPALIH    50
    STHSLTNSHA HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR 100
    GHFCDVTVRI HGSMLRAHRC VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS 150
    VQKLIDFMYS GVLRVSQSEA LQILTAASIL QIKTVIDECT RIVSQNVGDV 200
    FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV DRIYSALYAC 250
    SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER 300
    YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER 350
    NESEECTEDT DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGPGAAR 400
    DSQAEPTQPE QAAEAPAEGG PQTNQLETGA SSPERSNEVE MDSTVITVSN 450
    SSDKSVLQQP SVNTSIGQPL PSTQLYLRQT ETLTSNLRMP LTLTSNTQVI 500
    GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLAGQQTQFV TVSQPGLSTF 550
    TAQLPAPQPL ASSAGHSTAS GQGEKKPYEC TLCNKTFTAK QNYVKHMFVH 600
    TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN 650
    VHMRLHRGEK SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR 700
    AGPPGVVACT EGTTYVCSVC PAKFDQIEQF NDHMRMHVSD G 741
    Length:741
    Mass (Da):81,083
    Last modified:March 18, 2008 - v3
    Checksum:i913DDA9E6771C1EF
    GO
    Isoform 2 (identifier: Q9HC78-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-73: Missing.

    Show »
    Length:668
    Mass (Da):73,401
    Checksum:iF280249454E57C62
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti224 – 2241S → G in AAG28340. (PubMed:11352661)Curated
    Sequence conflicti266 – 2661V → M in AAG28340. (PubMed:11352661)Curated
    Sequence conflicti332 – 3321E → G in CAH56190. (PubMed:17974005)Curated
    Sequence conflicti337 – 3371Y → F in AAG28340. (PubMed:11352661)Curated
    Sequence conflicti465 – 4651S → F in AAG28340. (PubMed:11352661)Curated
    Sequence conflicti517 – 5171A → V in AAG28340. (PubMed:11352661)Curated
    Sequence conflicti543 – 5431S → F in AAH29041. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7373Missing in isoform 2. 3 PublicationsVSP_032503Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF139460 mRNA. Translation: AAG28340.2.
    AL050276 mRNA. Translation: CAB43377.1.
    BX647778 mRNA. Translation: CAH56190.1.
    CH471052 Genomic DNA. Translation: EAW79598.1.
    BC029041 mRNA. Translation: AAH29041.1.
    CCDSiCCDS2981.1. [Q9HC78-2]
    CCDS54626.1. [Q9HC78-1]
    PIRiT08725.
    RefSeqiNP_001157814.1. NM_001164342.1. [Q9HC78-1]
    NP_001157815.1. NM_001164343.1. [Q9HC78-2]
    NP_001157816.1. NM_001164344.1. [Q9HC78-2]
    NP_001157817.1. NM_001164345.1. [Q9HC78-2]
    NP_001157818.1. NM_001164346.1. [Q9HC78-2]
    NP_001157819.1. NM_001164347.1. [Q9HC78-2]
    NP_056457.3. NM_015642.4. [Q9HC78-2]
    XP_005247396.1. XM_005247339.1. [Q9HC78-1]
    XP_005247397.1. XM_005247340.1. [Q9HC78-1]
    XP_005247398.1. XM_005247341.1. [Q9HC78-1]
    XP_005247399.1. XM_005247342.1. [Q9HC78-2]
    XP_005247400.1. XM_005247343.1. [Q9HC78-2]
    XP_006713640.1. XM_006713577.1. [Q9HC78-1]
    XP_006713641.1. XM_006713578.1. [Q9HC78-1]
    XP_006713643.1. XM_006713580.1. [Q9HC78-2]
    XP_006713644.1. XM_006713581.1. [Q9HC78-2]
    UniGeneiHs.202577.
    Hs.592414.
    Hs.655108.
    Hs.732516.
    Hs.744879.

    Genome annotation databases

    EnsembliENST00000357258; ENSP00000349803; ENSG00000181722. [Q9HC78-2]
    ENST00000393785; ENSP00000377375; ENSG00000181722. [Q9HC78-2]
    ENST00000462705; ENSP00000420324; ENSG00000181722. [Q9HC78-2]
    ENST00000464560; ENSP00000417307; ENSG00000181722. [Q9HC78-2]
    ENST00000471418; ENSP00000419902; ENSG00000181722. [Q9HC78-2]
    ENST00000474710; ENSP00000419153; ENSG00000181722. [Q9HC78-1]
    ENST00000481632; ENSP00000418092; ENSG00000181722. [Q9HC78-2]
    GeneIDi26137.
    KEGGihsa:26137.
    UCSCiuc003ebi.3. human. [Q9HC78-1]

    Polymorphism databases

    DMDMi172045933.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF139460 mRNA. Translation: AAG28340.2 .
    AL050276 mRNA. Translation: CAB43377.1 .
    BX647778 mRNA. Translation: CAH56190.1 .
    CH471052 Genomic DNA. Translation: EAW79598.1 .
    BC029041 mRNA. Translation: AAH29041.1 .
    CCDSi CCDS2981.1. [Q9HC78-2 ]
    CCDS54626.1. [Q9HC78-1 ]
    PIRi T08725.
    RefSeqi NP_001157814.1. NM_001164342.1. [Q9HC78-1 ]
    NP_001157815.1. NM_001164343.1. [Q9HC78-2 ]
    NP_001157816.1. NM_001164344.1. [Q9HC78-2 ]
    NP_001157817.1. NM_001164345.1. [Q9HC78-2 ]
    NP_001157818.1. NM_001164346.1. [Q9HC78-2 ]
    NP_001157819.1. NM_001164347.1. [Q9HC78-2 ]
    NP_056457.3. NM_015642.4. [Q9HC78-2 ]
    XP_005247396.1. XM_005247339.1. [Q9HC78-1 ]
    XP_005247397.1. XM_005247340.1. [Q9HC78-1 ]
    XP_005247398.1. XM_005247341.1. [Q9HC78-1 ]
    XP_005247399.1. XM_005247342.1. [Q9HC78-2 ]
    XP_005247400.1. XM_005247343.1. [Q9HC78-2 ]
    XP_006713640.1. XM_006713577.1. [Q9HC78-1 ]
    XP_006713641.1. XM_006713578.1. [Q9HC78-1 ]
    XP_006713643.1. XM_006713580.1. [Q9HC78-2 ]
    XP_006713644.1. XM_006713581.1. [Q9HC78-2 ]
    UniGenei Hs.202577.
    Hs.592414.
    Hs.655108.
    Hs.732516.
    Hs.744879.

    3D structure databases

    ProteinModelPortali Q9HC78.
    SMRi Q9HC78. Positions 81-190, 528-737.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117573. 5 interactions.
    IntActi Q9HC78. 2 interactions.
    MINTi MINT-2823546.
    STRINGi 9606.ENSP00000349803.

    PTM databases

    PhosphoSitei Q9HC78.

    Polymorphism databases

    DMDMi 172045933.

    Proteomic databases

    MaxQBi Q9HC78.
    PaxDbi Q9HC78.
    PRIDEi Q9HC78.

    Protocols and materials databases

    DNASUi 26137.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357258 ; ENSP00000349803 ; ENSG00000181722 . [Q9HC78-2 ]
    ENST00000393785 ; ENSP00000377375 ; ENSG00000181722 . [Q9HC78-2 ]
    ENST00000462705 ; ENSP00000420324 ; ENSG00000181722 . [Q9HC78-2 ]
    ENST00000464560 ; ENSP00000417307 ; ENSG00000181722 . [Q9HC78-2 ]
    ENST00000471418 ; ENSP00000419902 ; ENSG00000181722 . [Q9HC78-2 ]
    ENST00000474710 ; ENSP00000419153 ; ENSG00000181722 . [Q9HC78-1 ]
    ENST00000481632 ; ENSP00000418092 ; ENSG00000181722 . [Q9HC78-2 ]
    GeneIDi 26137.
    KEGGi hsa:26137.
    UCSCi uc003ebi.3. human. [Q9HC78-1 ]

    Organism-specific databases

    CTDi 26137.
    GeneCardsi GC03M114056.
    HGNCi HGNC:13503. ZBTB20.
    HPAi HPA015551.
    HPA016815.
    MIMi 606025. gene.
    neXtProti NX_Q9HC78.
    PharmGKBi PA37789.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000136747.
    HOVERGENi HBG060183.
    InParanoidi Q9HC78.
    KOi K10501.
    OMAi QIEHFND.
    OrthoDBi EOG7GQXV7.
    PhylomeDBi Q9HC78.
    TreeFami TF335684.

    Miscellaneous databases

    ChiTaRSi ZBTB20. human.
    GeneWikii ZBTB20.
    GenomeRNAii 26137.
    NextBioi 48181.
    PROi Q9HC78.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HC78.
    Bgeei Q9HC78.
    CleanExi HS_ZBTB20.
    Genevestigatori Q9HC78.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6."
      Zhang W., Mi J., Li N., Sui L., Wan T., Zhang J., Chen T., Cao X.
      Biochem. Biophys. Res. Commun. 282:1067-1073(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Endometrium.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Colon.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND SER-472, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiZBT20_HUMAN
    AccessioniPrimary (citable) accession number: Q9HC78
    Secondary accession number(s): Q63HP6, Q8N6R5, Q9Y410
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3