ID CRLF2_HUMAN Reviewed; 371 AA. AC Q9HC73; J3QKD1; Q5G7M1; Q9H5R3; DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 27-MAR-2024, entry version 182. DE RecName: Full=Cytokine receptor-like factor 2; DE AltName: Full=Cytokine receptor-like 2; DE AltName: Full=IL-XR; DE AltName: Full=Thymic stromal lymphopoietin protein receptor; DE Short=TSLP receptor; DE Flags: Precursor; GN Name=CRLF2; Synonyms=CRL2, ILXR, TSLPR; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Dendritic cell; RX PubMed=11237741; DOI=10.1006/bbrc.2001.4432; RA Zhang W., Wang J., Wang Q., Chen G., Zhang J., Chen T., Wan T., Zhang Y., RA Cao X.; RT "Identification of a novel type I cytokine receptor CRL2 preferentially RT expressed by human dendritic cells and activated monocytes."; RL Biochem. Biophys. Res. Commun. 281:878-883(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=T-cell; RX PubMed=11474172; DOI=10.1159/000056941; RA Tonozuka Y., Fujio K., Sugiyama T., Nosaka T., Hirai M., Kitamura T.; RT "Molecular cloning of a human novel type I cytokine receptor related to RT delta1/TSLPR."; RL Cytogenet. Cell Genet. 93:23-25(2001). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION AS A RECEPTOR FOR RP TSLP. RX PubMed=11418668; DOI=10.4049/jimmunol.167.1.336; RA Reche P.A., Soumelis V., Gorman D.M., Clifford T., Liu M.-R., Travis M., RA Zurawski S.M., Johnston J., Liu Y.-J., Spits H., de Waal Malefyt R., RA Kastelein R.A., Bazan J.F.; RT "Human thymic stromal lymphopoietin preferentially stimulates myeloid RT cells."; RL J. Immunol. 167:336-343(2001). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). RA Li T., Yu X., Cao J., Wang S., Li X., Cui Q., Chen J., Zhang S., Chang Z., RA Fu X., Liu L.; RT "Human thymic stromal lymphopoietin receptor presents three splicing RT variants in selected tumor cells and functionally cooperates with IL-2 RT receptor beta to activate mitogenic signals."; RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Lung; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., RA Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). CC -!- FUNCTION: Receptor for thymic stromal lymphopoietin (TSLP). Forms a CC functional complex with TSLP and IL7R which is capable of stimulating CC cell proliferation through activation of STAT3 and STAT5. Also CC activates JAK2 (By similarity). Implicated in the development of the CC hematopoietic system. {ECO:0000250, ECO:0000269|PubMed:11418668}. CC -!- SUBUNIT: Heterodimer of CRLF2 and IL7R. CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single- CC pass type I membrane protein {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9HC73-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9HC73-2; Sequence=VSP_008786, VSP_008787; CC Name=3; CC IsoId=Q9HC73-3; Sequence=VSP_057463; CC -!- TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, kidney and CC adult and fetal liver. Primarily expressed in dendrites and monocytes. CC Weakly expressed in T-cells. CC -!- INDUCTION: Up-regulated in activated peripheral monocytes and THP-1 CC cells. CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein CC folding and thereby efficient intracellular transport and cell-surface CC receptor binding. CC -!- DOMAIN: The box 1 motif is important for association with JAKs. CC -!- MISCELLANEOUS: The gene coding for this protein is located in the CC pseudoautosomal region 1 (PAR1) of X and Y chromosomes. CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 5 CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF142570; AAG27923.1; -; mRNA. DR EMBL; AB052639; BAB60717.1; -; mRNA. DR EMBL; AF338733; AAK60618.1; -; mRNA. DR EMBL; AY775789; AAW66851.1; -; mRNA. DR EMBL; AK026800; BAB15557.1; -; mRNA. DR EMBL; AC188046; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX908382; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR CCDS; CCDS75944.1; -. [Q9HC73-3] DR CCDS; CCDS75945.1; -. [Q9HC73-1] DR RefSeq; NP_001012288.2; NM_001012288.2. [Q9HC73-3] DR RefSeq; NP_071431.2; NM_022148.3. [Q9HC73-1] DR PDB; 5J11; X-ray; 2.56 A; C=1-221. DR PDB; 5J12; X-ray; 3.55 A; C=1-221. DR PDBsum; 5J11; -. DR PDBsum; 5J12; -. DR AlphaFoldDB; Q9HC73; -. DR SASBDB; Q9HC73; -. DR SMR; Q9HC73; -. DR BioGRID; 122066; 71. DR STRING; 9606.ENSP00000370978; -. DR GlyCosmos; Q9HC73; 4 sites, No reported glycans. DR GlyGen; Q9HC73; 4 sites. DR iPTMnet; Q9HC73; -. DR PhosphoSitePlus; Q9HC73; -. DR BioMuta; CRLF2; -. DR DMDM; 38257768; -. DR MassIVE; Q9HC73; -. DR PaxDb; 9606-ENSP00000383641; -. DR PeptideAtlas; Q9HC73; -. DR Antibodypedia; 23333; 587 antibodies from 34 providers. DR DNASU; 64109; -. DR Ensembl; ENST00000381567.8; ENSP00000370979.4; ENSG00000205755.13. [Q9HC73-3] DR Ensembl; ENST00000400841.8; ENSP00000383641.3; ENSG00000205755.13. [Q9HC73-1] DR Ensembl; ENST00000711254.1; ENSP00000518625.1; ENSG00000292363.1. [Q9HC73-1] DR Ensembl; ENST00000711256.1; ENSP00000518623.1; ENSG00000292363.1. [Q9HC73-3] DR GeneID; 64109; -. DR KEGG; hsa:64109; -. DR MANE-Select; ENST00000400841.8; ENSP00000383641.3; NM_022148.4; NP_071431.2. DR UCSC; uc004cpl.4; human. DR UCSC; uc022brs.3; human. [Q9HC73-1] DR AGR; HGNC:14281; -. DR CTD; 64109; -. DR DisGeNET; 64109; -. DR GeneCards; CRLF2; -. DR HGNC; HGNC:14281; CRLF2. DR HPA; ENSG00000205755; Tissue enhanced (bone marrow, gallbladder, lymphoid tissue). DR MalaCards; CRLF2; -. DR MIM; 300357; gene. DR MIM; 400023; gene. DR neXtProt; NX_Q9HC73; -. DR OpenTargets; ENSG00000205755; -. DR PharmGKB; PA26883; -. DR VEuPathDB; HostDB:ENSG00000205755; -. DR eggNOG; ENOG502RYG2; Eukaryota. DR GeneTree; ENSGT00510000049974; -. DR HOGENOM; CLU_060544_0_0_1; -. DR InParanoid; Q9HC73; -. DR OMA; DLNFQWH; -. DR OrthoDB; 5355811at2759; -. DR PhylomeDB; Q9HC73; -. DR TreeFam; TF342693; -. DR PathwayCommons; Q9HC73; -. DR Reactome; R-HSA-1266695; Interleukin-7 signaling. DR SignaLink; Q9HC73; -. DR SIGNOR; Q9HC73; -. DR BioGRID-ORCS; 64109; 3 hits in 207 CRISPR screens. DR ChiTaRS; CRLF2; human. DR GenomeRNAi; 64109; -. DR Pharos; Q9HC73; Tbio. DR PRO; PR:Q9HC73; -. DR Proteomes; UP000005640; Chromosome X. DR Proteomes; UP000005640; Chromosome Y. DR RNAct; Q9HC73; Protein. DR Bgee; ENSG00000205755; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 48 other cell types or tissues. DR ExpressionAtlas; Q9HC73; baseline and differential. DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0043235; C:receptor complex; IBA:GO_Central. DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central. DR GO; GO:0004896; F:cytokine receptor activity; IDA:UniProtKB. DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IDA:UniProtKB. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:UniProtKB. DR GO; GO:0032754; P:positive regulation of interleukin-5 production; IMP:UniProtKB. DR GO; GO:0033005; P:positive regulation of mast cell activation; IMP:UniProtKB. DR GO; GO:1904894; P:positive regulation of receptor signaling pathway via STAT; IDA:UniProtKB. DR CDD; cd00063; FN3; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 2. DR InterPro; IPR048648; CRLF2-like_D2. DR InterPro; IPR048651; CRLF2_D1. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR013783; Ig-like_fold. DR PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1. DR PANTHER; PTHR23037:SF41; CYTOKINE RECEPTOR-LIKE FACTOR 2-RELATED; 1. DR Pfam; PF21605; CRLF2-like_D2; 1. DR Pfam; PF21604; CRLF2_D1; 1. DR SUPFAM; SSF49265; Fibronectin type III; 2. DR PROSITE; PS50853; FN3; 1. DR Genevisible; Q9HC73; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Cell membrane; Disulfide bond; KW Glycoprotein; Membrane; Receptor; Reference proteome; Secreted; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1..22 FT /evidence="ECO:0000255" FT CHAIN 23..371 FT /note="Cytokine receptor-like factor 2" FT /id="PRO_0000011041" FT TOPO_DOM 23..231 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 232..252 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 253..371 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT DOMAIN 118..211 FT /note="Fibronectin type-III" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REGION 322..347 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOTIF 200..204 FT /note="WSXWS motif" FT MOTIF 261..269 FT /note="Box 1 motif" FT CARBOHYD 47 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 55 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 101 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 169 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 71..84 FT /evidence="ECO:0000250|UniProtKB:Q8CII9" FT DISULFID 180..218 FT /evidence="ECO:0000250|UniProtKB:Q8CII9" FT VAR_SEQ 1..112 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|Ref.4" FT /id="VSP_057463" FT VAR_SEQ 162..233 FT /note="SKQENTCNVTIEGLDAEKCYSFWVRVKAMEDVYGPDTYPSDWSEVTCWQRGE FT IRDACAETPTPPKPKLSKFI -> TQSRSVTQAGVQWCDLCLLQPSPPRFKRFSCLSLP FT SSWDYRHPPPRLANFCIISRDGVSPCWPGWSRTCDLR (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_008786" FT VAR_SEQ 234..371 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_008787" FT CONFLICT 27 FT /note="Missing (in Ref. 5; BAB15557)" FT /evidence="ECO:0000305" FT CONFLICT 258 FT /note="K -> R (in Ref. 4; AAW66851)" FT CONFLICT 305 FT /note="E -> G (in Ref. 4; AAW66851)" FT CONFLICT 358 FT /note="G -> D (in Ref. 4; AAW66851)" FT STRAND 31..37 FT /evidence="ECO:0007829|PDB:5J11" FT TURN 38..40 FT /evidence="ECO:0007829|PDB:5J11" FT STRAND 41..47 FT /evidence="ECO:0007829|PDB:5J11" FT HELIX 49..51 FT /evidence="ECO:0007829|PDB:5J11" FT STRAND 57..63 FT /evidence="ECO:0007829|PDB:5J11" FT STRAND 72..77 FT /evidence="ECO:0007829|PDB:5J11" FT STRAND 80..87 FT /evidence="ECO:0007829|PDB:5J11" FT STRAND 94..101 FT /evidence="ECO:0007829|PDB:5J11" FT STRAND 104..112 FT /evidence="ECO:0007829|PDB:5J11" FT HELIX 113..116 FT /evidence="ECO:0007829|PDB:5J11" FT STRAND 126..129 FT /evidence="ECO:0007829|PDB:5J11" FT STRAND 131..137 FT /evidence="ECO:0007829|PDB:5J11" FT STRAND 145..153 FT /evidence="ECO:0007829|PDB:5J11" FT STRAND 161..174 FT /evidence="ECO:0007829|PDB:5J11" FT STRAND 181..189 FT /evidence="ECO:0007829|PDB:5J11" FT HELIX 191..194 FT /evidence="ECO:0007829|PDB:5J11" FT STRAND 207..210 FT /evidence="ECO:0007829|PDB:5J11" FT STRAND 213..216 FT /evidence="ECO:0007829|PDB:5J11" SQ SEQUENCE 371 AA; 42013 MW; DEA53814758B69E4 CRC64; MGRLVLLWGA AVFLLGGWMA LGQGGAAEGV QIQIIYFNLE TVQVTWNASK YSRTNLTFHY RFNGDEAYDQ CTNYLLQEGH TSGCLLDAEQ RDDILYFSIR NGTHPVFTAS RWMVYYLKPS SPKHVRFSWH QDAVTVTCSD LSYGDLLYEV QYRSPFDTEW QSKQENTCNV TIEGLDAEKC YSFWVRVKAM EDVYGPDTYP SDWSEVTCWQ RGEIRDACAE TPTPPKPKLS KFILISSLAI LLMVSLLLLS LWKLWRVKKF LIPSVPDPKS IFPGLFEIHQ GNFQEWITDT QNVAHLHKMA GAEQESGPEE PLVVQLAKTE AESPRMLDPQ TEEKEASGGS LQLPHQPLQG GDVVTIGGFT FVMNDRSYVA L //