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Q9HC73

- CRLF2_HUMAN

UniProt

Q9HC73 - CRLF2_HUMAN

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Protein

Cytokine receptor-like factor 2

Gene

CRLF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.By similarity1 Publication

GO - Biological processi

  1. immunoglobulin secretion involved in immune response Source: Ensembl
  2. inflammatory response Source: Ensembl
  3. T-helper 2 cell cytokine production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

SignaLinkiQ9HC73.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor-like factor 2
Alternative name(s):
Cytokine receptor-like 2
IL-XR
Thymic stromal lymphopoietin protein receptor
Short name:
TSLP receptor
Gene namesi
Name:CRLF2
Synonyms:CRL2, ILXR, TSLPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:14281. CRLF2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 231209ExtracellularSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Topological domaini253 – 371119CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26883.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 371349Cytokine receptor-like factor 2PRO_0000011041Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi71 ↔ 84By similarity
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9HC73.
PRIDEiQ9HC73.

PTM databases

PhosphoSiteiQ9HC73.

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.

Inductioni

Up-regulated in activated peripheral monocytes and THP-1 cells.

Gene expression databases

CleanExiHS_CRLF2.
ExpressionAtlasiQ9HC73. baseline and differential.
GenevestigatoriQ9HC73.

Interactioni

Subunit structurei

Heterodimer of CRLF2 and IL7R.

Protein-protein interaction databases

STRINGi9606.ENSP00000370979.

Structurei

3D structure databases

ProteinModelPortaliQ9HC73.
SMRiQ9HC73. Positions 34-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini118 – 21194Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi200 – 2045WSXWS motif
Motifi261 – 2699Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is important for association with JAKs.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74051.
GeneTreeiENSGT00510000049974.
HOGENOMiHOG000172557.
HOVERGENiHBG097013.
InParanoidiQ9HC73.
KOiK05078.
OMAiHMSISIC.
PhylomeDBiQ9HC73.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HC73-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRLVLLWGA AVFLLGGWMA LGQGGAAEGV QIQIIYFNLE TVQVTWNASK
60 70 80 90 100
YSRTNLTFHY RFNGDEAYDQ CTNYLLQEGH TSGCLLDAEQ RDDILYFSIR
110 120 130 140 150
NGTHPVFTAS RWMVYYLKPS SPKHVRFSWH QDAVTVTCSD LSYGDLLYEV
160 170 180 190 200
QYRSPFDTEW QSKQENTCNV TIEGLDAEKC YSFWVRVKAM EDVYGPDTYP
210 220 230 240 250
SDWSEVTCWQ RGEIRDACAE TPTPPKPKLS KFILISSLAI LLMVSLLLLS
260 270 280 290 300
LWKLWRVKKF LIPSVPDPKS IFPGLFEIHQ GNFQEWITDT QNVAHLHKMA
310 320 330 340 350
GAEQESGPEE PLVVQLAKTE AESPRMLDPQ TEEKEASGGS LQLPHQPLQG
360 370
GDVVTIGGFT FVMNDRSYVA L
Length:371
Mass (Da):42,013
Last modified:March 1, 2001 - v1
Checksum:iDEA53814758B69E4
GO
Isoform 2 (identifier: Q9HC73-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-233: SKQENTCNVT...PPKPKLSKFI → TQSRSVTQAG...PGWSRTCDLR
     234-371: Missing.

Note: No experimental confirmation available.

Show »
Length:233
Mass (Da):26,774
Checksum:i6ACA668AF4CAE9D4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271Missing in BAB15557. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei162 – 23372SKQEN…LSKFI → TQSRSVTQAGVQWCDLCLLQ PSPPRFKRFSCLSLPSSWDY RHPPPRLANFCIISRDGVSP CWPGWSRTCDLR in isoform 2. 1 PublicationVSP_008786Add
BLAST
Alternative sequencei234 – 371138Missing in isoform 2. 1 PublicationVSP_008787Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142570 mRNA. Translation: AAG27923.1.
AB052639 mRNA. Translation: BAB60717.1.
AF338733 mRNA. Translation: AAK60618.1.
AK026800 mRNA. Translation: BAB15557.1.
CCDSiCCDS75945.1. [Q9HC73-1]
RefSeqiNP_001012288.2. NM_001012288.2.
NP_071431.2. NM_022148.3. [Q9HC73-1]
UniGeneiHs.287729.

Genome annotation databases

EnsembliENST00000381566; ENSP00000370978; ENSG00000205755. [Q9HC73-1]
ENST00000400841; ENSP00000383641; ENSG00000205755. [Q9HC73-1]
ENST00000467626; ENSP00000485269; ENSG00000205755.
GeneIDi64109.
KEGGihsa:64109.
UCSCiuc004cpk.2. human. [Q9HC73-1]

Polymorphism databases

DMDMi38257768.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF142570 mRNA. Translation: AAG27923.1 .
AB052639 mRNA. Translation: BAB60717.1 .
AF338733 mRNA. Translation: AAK60618.1 .
AK026800 mRNA. Translation: BAB15557.1 .
CCDSi CCDS75945.1. [Q9HC73-1 ]
RefSeqi NP_001012288.2. NM_001012288.2.
NP_071431.2. NM_022148.3. [Q9HC73-1 ]
UniGenei Hs.287729.

3D structure databases

ProteinModelPortali Q9HC73.
SMRi Q9HC73. Positions 34-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000370979.

PTM databases

PhosphoSitei Q9HC73.

Polymorphism databases

DMDMi 38257768.

Proteomic databases

PaxDbi Q9HC73.
PRIDEi Q9HC73.

Protocols and materials databases

DNASUi 64109.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381566 ; ENSP00000370978 ; ENSG00000205755 . [Q9HC73-1 ]
ENST00000400841 ; ENSP00000383641 ; ENSG00000205755 . [Q9HC73-1 ]
ENST00000467626 ; ENSP00000485269 ; ENSG00000205755 .
GeneIDi 64109.
KEGGi hsa:64109.
UCSCi uc004cpk.2. human. [Q9HC73-1 ]

Organism-specific databases

CTDi 64109.
GeneCardsi GC0XM001274.
HGNCi HGNC:14281. CRLF2.
MIMi 300357. gene.
400023. gene.
neXtProti NX_Q9HC73.
PharmGKBi PA26883.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG74051.
GeneTreei ENSGT00510000049974.
HOGENOMi HOG000172557.
HOVERGENi HBG097013.
InParanoidi Q9HC73.
KOi K05078.
OMAi HMSISIC.
PhylomeDBi Q9HC73.

Enzyme and pathway databases

SignaLinki Q9HC73.

Miscellaneous databases

ChiTaRSi CRLF2. human.
GenomeRNAii 64109.
NextBioi 65960.
PROi Q9HC73.
SOURCEi Search...

Gene expression databases

CleanExi HS_CRLF2.
ExpressionAtlasi Q9HC73. baseline and differential.
Genevestigatori Q9HC73.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes."
    Zhang W., Wang J., Wang Q., Chen G., Zhang J., Chen T., Wan T., Zhang Y., Cao X.
    Biochem. Biophys. Res. Commun. 281:878-883(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Dendritic cell.
  2. "Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR."
    Tonozuka Y., Fujio K., Sugiyama T., Nosaka T., Hirai M., Kitamura T.
    Cytogenet. Cell Genet. 93:23-25(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: T-cell.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS A RECEPTOR FOR TSLP.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.

Entry informationi

Entry nameiCRLF2_HUMAN
AccessioniPrimary (citable) accession number: Q9HC73
Secondary accession number(s): Q9H5R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3