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Q9HC73

- CRLF2_HUMAN

UniProt

Q9HC73 - CRLF2_HUMAN

Protein

Cytokine receptor-like factor 2

Gene

CRLF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 By similarity. Implicated in the development of the hematopoietic system.By similarity1 Publication

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    SignaLinkiQ9HC73.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytokine receptor-like factor 2
    Alternative name(s):
    Cytokine receptor-like 2
    IL-XR
    Thymic stromal lymphopoietin protein receptor
    Short name:
    TSLP receptor
    Gene namesi
    Name:CRLF2
    Synonyms:CRL2, ILXR, TSLPR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:14281. CRLF2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26883.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 371349Cytokine receptor-like factor 2PRO_0000011041Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi71 ↔ 84By similarity
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9HC73.
    PRIDEiQ9HC73.

    PTM databases

    PhosphoSiteiQ9HC73.

    Expressioni

    Tissue specificityi

    Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.

    Inductioni

    Up-regulated in activated peripheral monocytes and THP-1 cells.

    Gene expression databases

    CleanExiHS_CRLF2.
    GenevestigatoriQ9HC73.

    Interactioni

    Subunit structurei

    Heterodimer of CRLF2 and IL7R.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000370979.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HC73.
    SMRiQ9HC73. Positions 31-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 231209ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini253 – 371119CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini118 – 21194Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi200 – 2045WSXWS motif
    Motifi261 – 2699Box 1 motif

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is important for association with JAKs.

    Sequence similaritiesi

    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG74051.
    HOGENOMiHOG000172557.
    HOVERGENiHBG097013.
    InParanoidiQ9HC73.
    KOiK05078.
    OMAiHMSISIC.
    PhylomeDBiQ9HC73.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HC73-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRLVLLWGA AVFLLGGWMA LGQGGAAEGV QIQIIYFNLE TVQVTWNASK    50
    YSRTNLTFHY RFNGDEAYDQ CTNYLLQEGH TSGCLLDAEQ RDDILYFSIR 100
    NGTHPVFTAS RWMVYYLKPS SPKHVRFSWH QDAVTVTCSD LSYGDLLYEV 150
    QYRSPFDTEW QSKQENTCNV TIEGLDAEKC YSFWVRVKAM EDVYGPDTYP 200
    SDWSEVTCWQ RGEIRDACAE TPTPPKPKLS KFILISSLAI LLMVSLLLLS 250
    LWKLWRVKKF LIPSVPDPKS IFPGLFEIHQ GNFQEWITDT QNVAHLHKMA 300
    GAEQESGPEE PLVVQLAKTE AESPRMLDPQ TEEKEASGGS LQLPHQPLQG 350
    GDVVTIGGFT FVMNDRSYVA L 371
    Length:371
    Mass (Da):42,013
    Last modified:March 1, 2001 - v1
    Checksum:iDEA53814758B69E4
    GO
    Isoform 2 (identifier: Q9HC73-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         162-233: SKQENTCNVT...PPKPKLSKFI → TQSRSVTQAG...PGWSRTCDLR
         234-371: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:233
    Mass (Da):26,774
    Checksum:i6ACA668AF4CAE9D4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271Missing in BAB15557. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei162 – 23372SKQEN…LSKFI → TQSRSVTQAGVQWCDLCLLQ PSPPRFKRFSCLSLPSSWDY RHPPPRLANFCIISRDGVSP CWPGWSRTCDLR in isoform 2. 1 PublicationVSP_008786Add
    BLAST
    Alternative sequencei234 – 371138Missing in isoform 2. 1 PublicationVSP_008787Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF142570 mRNA. Translation: AAG27923.1.
    AB052639 mRNA. Translation: BAB60717.1.
    AF338733 mRNA. Translation: AAK60618.1.
    AK026800 mRNA. Translation: BAB15557.1.
    RefSeqiNP_001012288.2. NM_001012288.2.
    NP_071431.2. NM_022148.3. [Q9HC73-1]
    UniGeneiHs.287729.

    Genome annotation databases

    EnsembliENST00000381566; ENSP00000370978; ENSG00000205755. [Q9HC73-2]
    GeneIDi64109.
    KEGGihsa:64109.
    UCSCiuc004cpk.2. human. [Q9HC73-1]

    Polymorphism databases

    DMDMi38257768.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF142570 mRNA. Translation: AAG27923.1 .
    AB052639 mRNA. Translation: BAB60717.1 .
    AF338733 mRNA. Translation: AAK60618.1 .
    AK026800 mRNA. Translation: BAB15557.1 .
    RefSeqi NP_001012288.2. NM_001012288.2.
    NP_071431.2. NM_022148.3. [Q9HC73-1 ]
    UniGenei Hs.287729.

    3D structure databases

    ProteinModelPortali Q9HC73.
    SMRi Q9HC73. Positions 31-209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000370979.

    PTM databases

    PhosphoSitei Q9HC73.

    Polymorphism databases

    DMDMi 38257768.

    Proteomic databases

    PaxDbi Q9HC73.
    PRIDEi Q9HC73.

    Protocols and materials databases

    DNASUi 64109.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381566 ; ENSP00000370978 ; ENSG00000205755 . [Q9HC73-2 ]
    GeneIDi 64109.
    KEGGi hsa:64109.
    UCSCi uc004cpk.2. human. [Q9HC73-1 ]

    Organism-specific databases

    CTDi 64109.
    GeneCardsi GC0XM001274.
    HGNCi HGNC:14281. CRLF2.
    MIMi 300357. gene.
    400023. gene.
    neXtProti NX_Q9HC73.
    PharmGKBi PA26883.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74051.
    HOGENOMi HOG000172557.
    HOVERGENi HBG097013.
    InParanoidi Q9HC73.
    KOi K05078.
    OMAi HMSISIC.
    PhylomeDBi Q9HC73.

    Enzyme and pathway databases

    SignaLinki Q9HC73.

    Miscellaneous databases

    ChiTaRSi CRLF2. human.
    GenomeRNAii 64109.
    NextBioi 65960.
    PROi Q9HC73.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_CRLF2.
    Genevestigatori Q9HC73.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes."
      Zhang W., Wang J., Wang Q., Chen G., Zhang J., Chen T., Wan T., Zhang Y., Cao X.
      Biochem. Biophys. Res. Commun. 281:878-883(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Dendritic cell.
    2. "Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR."
      Tonozuka Y., Fujio K., Sugiyama T., Nosaka T., Hirai M., Kitamura T.
      Cytogenet. Cell Genet. 93:23-25(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: T-cell.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION AS A RECEPTOR FOR TSLP.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung.

    Entry informationi

    Entry nameiCRLF2_HUMAN
    AccessioniPrimary (citable) accession number: Q9HC73
    Secondary accession number(s): Q9H5R3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3