Sodium/potassium/calcium exchanger 3 precursor

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Q9HC58 (NCKX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Sodium/potassium/calcium exchanger 3

Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 3
Solute carrier family 24 member 3

Gene names

Name:	SLC24A3
Synonyms:	NCKX3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	644 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transports 1 Ca²⁺ and 1 K⁺ in exchange for 4 Na⁺ By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Abundant in the brain. Expressed at low levels in the aorta, uterus and intestine.
Sequence similarities	Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.

Ontologies

Keywords
Biological process	Antiport Calcium transport Ion transport Potassium transport Sodium transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Potassium Sodium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ion transport Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	calcium, potassium:sodium antiporter activity Inferred from electronic annotation. Source: Compara symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 44

Potential

Chain

45 – 644

600

Sodium/potassium/calcium exchanger 3

PRO_0000019370

Regions

Topological domain

45 – 107

Extracellular Potential

Transmembrane

108 – 128

Helical; Potential

Topological domain

129 – 153

Cytoplasmic Potential

Transmembrane

154 – 174

Helical; Potential

Topological domain

175 – 182

Extracellular Potential

Transmembrane

183 – 203

Helical; Potential

Topological domain

204 – 210

Cytoplasmic Potential

Transmembrane

211 – 231

Helical; Potential

Topological domain

232 – 234

Extracellular Potential

Transmembrane

235 – 255

Helical; Potential

Topological domain

256 – 484

229

Cytoplasmic Potential

Transmembrane

485 – 505

Helical; Potential

Topological domain

506 – 510

Extracellular Potential

Transmembrane

511 – 531

Helical; Potential

Topological domain

532 – 549

Cytoplasmic Potential

Transmembrane

550 – 570

Helical; Potential

Topological domain

571 – 580

Extracellular Potential

Transmembrane

581 – 601

Helical; Potential

Topological domain

602 – 615

Cytoplasmic Potential

Transmembrane

616 – 636

Helical; Potential

Topological domain

637 – 644

Extracellular Potential

Repeat

149 – 189

Alpha-1

Repeat

518 – 549

Alpha-2

Compositional bias

422 – 428

Poly-Glu

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

L → P.
Corresponds to variant rs3790174 [ dbSNP | Ensembl ].

VAR_028024

Natural variant

V → I. Ref.1
Corresponds to variant rs1569767 [ dbSNP | Ensembl ].

VAR_028025

Natural variant

168

V → I.
Corresponds to variant rs3790267 [ dbSNP | Ensembl ].

VAR_028026

Natural variant

271

G → S.
Corresponds to variant rs6136807 [ dbSNP | Ensembl ].

VAR_028027

Sequences

Sequence

Length

Mass (Da)

Tools

Q9HC58 [UniParc].

Last modified October 17, 2006. Version 4.
Checksum: 84247571AC2EEE7B
Show »

FASTA

644

71,992

        10         20         30         40         50         60 
MRPSGDEDRA RRRRRRRRRR DLLLSQLCFL ASVALLLWSL SSLREQKELD LMDLVGEDRK 

        70         80         90        100        110        120 
WMMARKLMQV NDTLTSEDAG LRNSKNCTEP ALHEFPNDIF TNEDRRQGAV VLHVLCAIYM 

       130        140        150        160        170        180 
FYALAIVCDD FFVPSLEKIC ERLHLSEDVA GATFMAAGSS APELFTSVIG VFITKGDVGV 

       190        200        210        220        230        240 
GTIVGSAVFN ILCIIGVCGL FAGQVVALSS WCLLRDSIYY TLSVIALIVF IYDEKVSWWE 

       250        260        270        280        290        300 
SLVLVLMYLI YIVIMKYNAC IHQCFERRTK GAGNMVNGLA NNAEIDDSSN CDATVVLLKK 

       310        320        330        340        350        360 
ANFHRKASVI MVDELLSAYP HQLSFSEAGL RIMITSHFPP KTRLSMASRM LINERQRLIN 

       370        380        390        400        410        420 
SRAYTNGESE VAIKIPIKHT VENGTGPSSA PDRGVNGTRR DDVVAEAGNE TENENEDNEN 

       430        440        450        460        470        480 
DEEEEEDEDD DEGPYTPFDT PSGKLETVKW AFTWPLSFVL YFTVPNCNKP RWEKWFMVTF 

       490        500        510        520        530        540 
ASSTLWIAAF SYMMVWMVTI IGYTLGIPDV IMGITFLAAG TSVPDCMASL IVARQGMGDM 

       550        560        570        580        590        600 
AVSNSIGSNV FDILIGLGLP WALQTLAVDY GSYIRLNSRG LIYSVGLLLA SVFVTVFGVH 

       610        620        630        640 
LNKWQLDKKL GCGCLLLYGV FLCFSIMTEF NVFTFVNLPM CGDH

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3." Kraev A., Quednau B.D., Leach S., Li X.-F., Dong H., Winkfein R., Perizzolo M., Cai X., Yang R., Philipson K.D., Lytton J. J. Biol. Chem. 276:23161-23172(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-55. Tissue: Brain and Skeletal muscle.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF288087 mRNA. No translation available. AF169257 mRNA. Translation: AAG12988.2. AL121830 AL139429 Genomic DNA. Translation: CAC36052.2. AL049647 AL139429 Genomic DNA. Translation: CAC36050.2. AL034425 AL139429 Genomic DNA. Translation: CAC36051.2. AL121761 AL139429 Genomic DNA. Translation: CAC12640.2. AL139429 AL136090 Genomic DNA. Translation: CAC13155.2. AL136090 AL139429 Genomic DNA. Translation: CAI17163.1.
IPI	IPI00010272.
RefSeq	NP_065740.2. NM_020689.3.
UniGene	Hs.654790.
3D structure databases
ProteinModelPortal	Q9HC58.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000333519.
PTM databases
PhosphoSite	Q9HC58.
Polymorphism databases
DMDM	116242671.
Proteomic databases
PaxDb	Q9HC58.
PRIDE	Q9HC58.
Protocols and materials databases
DNASU	57419.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328041; ENSP00000333519; ENSG00000185052.
GeneID	57419.
KEGG	hsa:57419.
UCSC	uc002wrl.3. human.
Organism-specific databases
CTD	57419.
GeneCards	GC20P019141.
H-InvDB	HIX0040511.
HGNC	HGNC:10977. SLC24A3.
HPA	HPA043400. HPA045497.
MIM	609839. gene.
neXtProt	NX_Q9HC58.
PharmGKB	PA35853.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0530.
HOGENOM	HOG000231933.
HOVERGEN	HBG054881.
InParanoid	Q9HC58.
KO	K13751.
OMA	VHLNKWQ.
OrthoDB	EOG4TTGHN.
PhylomeDB	Q9HC58.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
Bgee	Q9HC58.
CleanEx	HS_SLC24A3.
Genevestigator	Q9HC58.
Family and domain databases
InterPro	IPR004481. K/Na/Ca-exchanger. IPR004837. NaCa_Exmemb. [Graphical view]
PANTHER	PTHR10846. PTHR10846. 1 hit.
Pfam	PF01699. Na_Ca_ex. 2 hits. [Graphical view]
TIGRFAMs	TIGR00367. TIGR00367. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	57419.
NextBio	63566.
SOURCE	Search...

Entry information

Entry name

NCKX3_HUMAN

Accession

Primary (citable) accession number: Q9HC58
Secondary accession number(s): B1AKV7

Q9H519

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2001
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 107 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents