Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium/potassium/calcium exchanger 3

Gene

SLC24A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Potassium transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Calcium, Potassium, Sodium

Enzyme and pathway databases

BioCyciZFISH:G66-30813-MONOMER.
ReactomeiR-HSA-425561. Sodium/Calcium exchangers.

Protein family/group databases

TCDBi2.A.19.4.10. the ca(2+):cation antiporter (caca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 3
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 3
Solute carrier family 24 member 3
Gene namesi
Name:SLC24A3
Synonyms:NCKX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:10977. SLC24A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini45 – 107ExtracellularSequence analysisAdd BLAST63
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 153CytoplasmicSequence analysisAdd BLAST25
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 182ExtracellularSequence analysis8
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 210CytoplasmicSequence analysis7
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 234ExtracellularSequence analysis3
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 484CytoplasmicSequence analysisAdd BLAST229
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21
Topological domaini506 – 510ExtracellularSequence analysis5
Transmembranei511 – 531HelicalSequence analysisAdd BLAST21
Topological domaini532 – 549CytoplasmicSequence analysisAdd BLAST18
Transmembranei550 – 570HelicalSequence analysisAdd BLAST21
Topological domaini571 – 580ExtracellularSequence analysis10
Transmembranei581 – 601HelicalSequence analysisAdd BLAST21
Topological domaini602 – 615CytoplasmicSequence analysisAdd BLAST14
Transmembranei616 – 636HelicalSequence analysisAdd BLAST21
Topological domaini637 – 644ExtracellularSequence analysis8

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57419.
OpenTargetsiENSG00000185052.
PharmGKBiPA35853.

Polymorphism and mutation databases

BioMutaiSLC24A3.
DMDMi116242671.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
ChainiPRO_000001937045 – 644Sodium/potassium/calcium exchanger 3Add BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Modified residuei308PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9HC58.
PeptideAtlasiQ9HC58.
PRIDEiQ9HC58.

PTM databases

iPTMnetiQ9HC58.
PhosphoSitePlusiQ9HC58.

Expressioni

Tissue specificityi

Abundant in the brain. Expressed at low levels in the aorta, uterus and intestine.

Gene expression databases

BgeeiENSG00000185052.
CleanExiHS_SLC24A3.
GenevisibleiQ9HC58. HS.

Organism-specific databases

HPAiHPA043400.
HPA045497.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333519.

Structurei

3D structure databases

ProteinModelPortaliQ9HC58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati149 – 189Alpha-1Add BLAST41
Repeati518 – 549Alpha-2Add BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi422 – 428Poly-Glu7

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
GeneTreeiENSGT00760000119209.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ9HC58.
KOiK13751.
OMAiLGCGCLF.
OrthoDBiEOG091G0M5C.
PhylomeDBiQ9HC58.
TreeFamiTF318759.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030248. SLC24A3.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF22. PTHR10846:SF22. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HC58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPSGDEDRA RRRRRRRRRR DLLLSQLCFL ASVALLLWSL SSLREQKELD
60 70 80 90 100
LMDLVGEDRK WMMARKLMQV NDTLTSEDAG LRNSKNCTEP ALHEFPNDIF
110 120 130 140 150
TNEDRRQGAV VLHVLCAIYM FYALAIVCDD FFVPSLEKIC ERLHLSEDVA
160 170 180 190 200
GATFMAAGSS APELFTSVIG VFITKGDVGV GTIVGSAVFN ILCIIGVCGL
210 220 230 240 250
FAGQVVALSS WCLLRDSIYY TLSVIALIVF IYDEKVSWWE SLVLVLMYLI
260 270 280 290 300
YIVIMKYNAC IHQCFERRTK GAGNMVNGLA NNAEIDDSSN CDATVVLLKK
310 320 330 340 350
ANFHRKASVI MVDELLSAYP HQLSFSEAGL RIMITSHFPP KTRLSMASRM
360 370 380 390 400
LINERQRLIN SRAYTNGESE VAIKIPIKHT VENGTGPSSA PDRGVNGTRR
410 420 430 440 450
DDVVAEAGNE TENENEDNEN DEEEEEDEDD DEGPYTPFDT PSGKLETVKW
460 470 480 490 500
AFTWPLSFVL YFTVPNCNKP RWEKWFMVTF ASSTLWIAAF SYMMVWMVTI
510 520 530 540 550
IGYTLGIPDV IMGITFLAAG TSVPDCMASL IVARQGMGDM AVSNSIGSNV
560 570 580 590 600
FDILIGLGLP WALQTLAVDY GSYIRLNSRG LIYSVGLLLA SVFVTVFGVH
610 620 630 640
LNKWQLDKKL GCGCLLLYGV FLCFSIMTEF NVFTFVNLPM CGDH
Length:644
Mass (Da):71,992
Last modified:October 17, 2006 - v4
Checksum:i84247571AC2EEE7B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02802449L → P.Corresponds to variant rs3790174dbSNPEnsembl.1
Natural variantiVAR_02802555V → I.1 PublicationCorresponds to variant rs1569767dbSNPEnsembl.1
Natural variantiVAR_028026168V → I.Corresponds to variant rs3790267dbSNPEnsembl.1
Natural variantiVAR_028027271G → S.Corresponds to variant rs6136807dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288087 mRNA. No translation available.
AF169257 mRNA. Translation: AAG12988.2.
AL121830
, AL034425, AL049647, AL121761, AL136090, AL139429 Genomic DNA. Translation: CAC36052.2.
AL049647
, AL034425, AL121761, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC36050.2.
AL034425
, AL049647, AL121761, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC36051.2.
AL121761
, AL034425, AL049647, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC12640.2.
AL139429
, AL034425, AL049647, AL121761, AL121830, AL136090 Genomic DNA. Translation: CAC13155.2.
AL136090
, AL034425, AL049647, AL121761, AL121830, AL139429 Genomic DNA. Translation: CAI17163.1.
CCDSiCCDS13140.1.
RefSeqiNP_065740.2. NM_020689.3.
UniGeneiHs.654790.

Genome annotation databases

EnsembliENST00000328041; ENSP00000333519; ENSG00000185052.
ENST00000613834; ENSP00000482967; ENSG00000185052.
GeneIDi57419.
KEGGihsa:57419.
UCSCiuc002wrl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288087 mRNA. No translation available.
AF169257 mRNA. Translation: AAG12988.2.
AL121830
, AL034425, AL049647, AL121761, AL136090, AL139429 Genomic DNA. Translation: CAC36052.2.
AL049647
, AL034425, AL121761, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC36050.2.
AL034425
, AL049647, AL121761, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC36051.2.
AL121761
, AL034425, AL049647, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC12640.2.
AL139429
, AL034425, AL049647, AL121761, AL121830, AL136090 Genomic DNA. Translation: CAC13155.2.
AL136090
, AL034425, AL049647, AL121761, AL121830, AL139429 Genomic DNA. Translation: CAI17163.1.
CCDSiCCDS13140.1.
RefSeqiNP_065740.2. NM_020689.3.
UniGeneiHs.654790.

3D structure databases

ProteinModelPortaliQ9HC58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333519.

Protein family/group databases

TCDBi2.A.19.4.10. the ca(2+):cation antiporter (caca) family.

PTM databases

iPTMnetiQ9HC58.
PhosphoSitePlusiQ9HC58.

Polymorphism and mutation databases

BioMutaiSLC24A3.
DMDMi116242671.

Proteomic databases

PaxDbiQ9HC58.
PeptideAtlasiQ9HC58.
PRIDEiQ9HC58.

Protocols and materials databases

DNASUi57419.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328041; ENSP00000333519; ENSG00000185052.
ENST00000613834; ENSP00000482967; ENSG00000185052.
GeneIDi57419.
KEGGihsa:57419.
UCSCiuc002wrl.4. human.

Organism-specific databases

CTDi57419.
DisGeNETi57419.
GeneCardsiSLC24A3.
H-InvDBHIX0040511.
HGNCiHGNC:10977. SLC24A3.
HPAiHPA043400.
HPA045497.
MIMi609839. gene.
neXtProtiNX_Q9HC58.
OpenTargetsiENSG00000185052.
PharmGKBiPA35853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
GeneTreeiENSGT00760000119209.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ9HC58.
KOiK13751.
OMAiLGCGCLF.
OrthoDBiEOG091G0M5C.
PhylomeDBiQ9HC58.
TreeFamiTF318759.

Enzyme and pathway databases

BioCyciZFISH:G66-30813-MONOMER.
ReactomeiR-HSA-425561. Sodium/Calcium exchangers.

Miscellaneous databases

ChiTaRSiSLC24A3. human.
GenomeRNAii57419.
PROiQ9HC58.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185052.
CleanExiHS_SLC24A3.
GenevisibleiQ9HC58. HS.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030248. SLC24A3.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF22. PTHR10846:SF22. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNCKX3_HUMAN
AccessioniPrimary (citable) accession number: Q9HC58
Secondary accession number(s): B1AKV7
, Q9BQJ9, Q9BQL7, Q9BQY3, Q9H519
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 135 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.