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Q9HC58 (NCKX3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/potassium/calcium exchanger 3
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 3
Solute carrier family 24 member 3
Gene names
Name:SLC24A3
Synonyms:NCKX3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length644 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+ By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Abundant in the brain. Expressed at low levels in the aorta, uterus and intestine.

Sequence similarities

Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4444 Potential
Chain45 – 644600Sodium/potassium/calcium exchanger 3
PRO_0000019370

Regions

Topological domain45 – 10763Extracellular Potential
Transmembrane108 – 12821Helical; Potential
Topological domain129 – 15325Cytoplasmic Potential
Transmembrane154 – 17421Helical; Potential
Topological domain175 – 1828Extracellular Potential
Transmembrane183 – 20321Helical; Potential
Topological domain204 – 2107Cytoplasmic Potential
Transmembrane211 – 23121Helical; Potential
Topological domain232 – 2343Extracellular Potential
Transmembrane235 – 25521Helical; Potential
Topological domain256 – 484229Cytoplasmic Potential
Transmembrane485 – 50521Helical; Potential
Topological domain506 – 5105Extracellular Potential
Transmembrane511 – 53121Helical; Potential
Topological domain532 – 54918Cytoplasmic Potential
Transmembrane550 – 57021Helical; Potential
Topological domain571 – 58010Extracellular Potential
Transmembrane581 – 60121Helical; Potential
Topological domain602 – 61514Cytoplasmic Potential
Transmembrane616 – 63621Helical; Potential
Topological domain637 – 6448Extracellular Potential
Repeat149 – 18941Alpha-1
Repeat518 – 54932Alpha-2
Compositional bias422 – 4287Poly-Glu

Amino acid modifications

Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation861N-linked (GlcNAc...) Potential

Natural variations

Natural variant491L → P.
Corresponds to variant rs3790174 [ dbSNP | Ensembl ].
VAR_028024
Natural variant551V → I. Ref.1
Corresponds to variant rs1569767 [ dbSNP | Ensembl ].
VAR_028025
Natural variant1681V → I.
Corresponds to variant rs3790267 [ dbSNP | Ensembl ].
VAR_028026
Natural variant2711G → S.
Corresponds to variant rs6136807 [ dbSNP | Ensembl ].
VAR_028027

Sequences

Sequence LengthMass (Da)Tools
Q9HC58 [UniParc].

Last modified October 17, 2006. Version 4.
Checksum: 84247571AC2EEE7B

FASTA64471,992
        10         20         30         40         50         60 
MRPSGDEDRA RRRRRRRRRR DLLLSQLCFL ASVALLLWSL SSLREQKELD LMDLVGEDRK 

        70         80         90        100        110        120 
WMMARKLMQV NDTLTSEDAG LRNSKNCTEP ALHEFPNDIF TNEDRRQGAV VLHVLCAIYM 

       130        140        150        160        170        180 
FYALAIVCDD FFVPSLEKIC ERLHLSEDVA GATFMAAGSS APELFTSVIG VFITKGDVGV 

       190        200        210        220        230        240 
GTIVGSAVFN ILCIIGVCGL FAGQVVALSS WCLLRDSIYY TLSVIALIVF IYDEKVSWWE 

       250        260        270        280        290        300 
SLVLVLMYLI YIVIMKYNAC IHQCFERRTK GAGNMVNGLA NNAEIDDSSN CDATVVLLKK 

       310        320        330        340        350        360 
ANFHRKASVI MVDELLSAYP HQLSFSEAGL RIMITSHFPP KTRLSMASRM LINERQRLIN 

       370        380        390        400        410        420 
SRAYTNGESE VAIKIPIKHT VENGTGPSSA PDRGVNGTRR DDVVAEAGNE TENENEDNEN 

       430        440        450        460        470        480 
DEEEEEDEDD DEGPYTPFDT PSGKLETVKW AFTWPLSFVL YFTVPNCNKP RWEKWFMVTF 

       490        500        510        520        530        540 
ASSTLWIAAF SYMMVWMVTI IGYTLGIPDV IMGITFLAAG TSVPDCMASL IVARQGMGDM 

       550        560        570        580        590        600 
AVSNSIGSNV FDILIGLGLP WALQTLAVDY GSYIRLNSRG LIYSVGLLLA SVFVTVFGVH 

       610        620        630        640 
LNKWQLDKKL GCGCLLLYGV FLCFSIMTEF NVFTFVNLPM CGDH 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3."
Kraev A., Quednau B.D., Leach S., Li X.-F., Dong H., Winkfein R., Perizzolo M., Cai X., Yang R., Philipson K.D., Lytton J.
J. Biol. Chem. 276:23161-23172(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-55.
Tissue: Brain and Skeletal muscle.
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF288087 mRNA. No translation available.
AF169257 mRNA. Translation: AAG12988.2.
AL121830 expand/collapse EMBL AC list , AL034425, AL049647, AL121761, AL136090, AL139429 Genomic DNA. Translation: CAC36052.2.
AL049647 expand/collapse EMBL AC list , AL034425, AL121761, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC36050.2.
AL034425 expand/collapse EMBL AC list , AL049647, AL121761, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC36051.2.
AL121761 expand/collapse EMBL AC list , AL034425, AL049647, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC12640.2.
AL139429 expand/collapse EMBL AC list , AL034425, AL049647, AL121761, AL121830, AL136090 Genomic DNA. Translation: CAC13155.2.
AL136090 expand/collapse EMBL AC list , AL034425, AL049647, AL121761, AL121830, AL139429 Genomic DNA. Translation: CAI17163.1.
CCDSCCDS13140.1.
RefSeqNP_065740.2. NM_020689.3.
UniGeneHs.654790.

3D structure databases

ProteinModelPortalQ9HC58.
SMRQ9HC58. Positions 130-252, 501-553.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000333519.

Protein family/group databases

TCDB2.A.19.4.10. the ca(2+):cation antiporter (caca) family.

PTM databases

PhosphoSiteQ9HC58.

Polymorphism databases

DMDM116242671.

Proteomic databases

PaxDbQ9HC58.
PRIDEQ9HC58.

Protocols and materials databases

DNASU57419.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328041; ENSP00000333519; ENSG00000185052.
GeneID57419.
KEGGhsa:57419.
UCSCuc002wrl.3. human.

Organism-specific databases

CTD57419.
GeneCardsGC20P019141.
H-InvDBHIX0040511.
HGNCHGNC:10977. SLC24A3.
HPAHPA043400.
HPA045497.
MIM609839. gene.
neXtProtNX_Q9HC58.
PharmGKBPA35853.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0530.
HOGENOMHOG000231933.
HOVERGENHBG054881.
InParanoidQ9HC58.
KOK13751.
OMAQVSWWES.
OrthoDBEOG776SP8.
PhylomeDBQ9HC58.
TreeFamTF318759.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

BgeeQ9HC58.
CleanExHS_SLC24A3.
GenevestigatorQ9HC58.

Family and domain databases

InterProIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
[Graphical view]
PANTHERPTHR10846. PTHR10846. 1 hit.
PfamPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsTIGR00367. TIGR00367. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi57419.
NextBio63566.
PROQ9HC58.
SOURCESearch...

Entry information

Entry nameNCKX3_HUMAN
AccessionPrimary (citable) accession number: Q9HC58
Secondary accession number(s): B1AKV7 expand/collapse secondary AC list , Q9BQJ9, Q9BQL7, Q9BQY3, Q9H519
Entry history
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 117 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM