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Q9HC58

- NCKX3_HUMAN

UniProt

Q9HC58 - NCKX3_HUMAN

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Protein

Sodium/potassium/calcium exchanger 3

Gene

SLC24A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.By similarity

GO - Molecular functioni

  1. calcium, potassium:sodium antiporter activity Source: Ensembl
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. ion transport Source: Reactome
  2. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Potassium transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Calcium, Potassium, Sodium

Enzyme and pathway databases

ReactomeiREACT_19320. Sodium/Calcium exchangers.

Protein family/group databases

TCDBi2.A.19.4.10. the ca(2+):cation antiporter (caca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 3
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 3
Solute carrier family 24 member 3
Gene namesi
Name:SLC24A3
Synonyms:NCKX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:10977. SLC24A3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4444Sequence AnalysisAdd
BLAST
Chaini45 – 644600Sodium/potassium/calcium exchanger 3PRO_0000019370Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9HC58.
PRIDEiQ9HC58.

PTM databases

PhosphoSiteiQ9HC58.

Expressioni

Tissue specificityi

Abundant in the brain. Expressed at low levels in the aorta, uterus and intestine.

Gene expression databases

BgeeiQ9HC58.
CleanExiHS_SLC24A3.
GenevestigatoriQ9HC58.

Organism-specific databases

HPAiHPA043400.
HPA045497.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333519.

Structurei

3D structure databases

ProteinModelPortaliQ9HC58.
SMRiQ9HC58. Positions 130-252, 501-553.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini45 – 10763ExtracellularSequence AnalysisAdd
BLAST
Topological domaini129 – 15325CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini175 – 1828ExtracellularSequence Analysis
Topological domaini204 – 2107CytoplasmicSequence Analysis
Topological domaini232 – 2343ExtracellularSequence Analysis
Topological domaini256 – 484229CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini506 – 5105ExtracellularSequence Analysis
Topological domaini532 – 54918CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini571 – 58010ExtracellularSequence Analysis
Topological domaini602 – 61514CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini637 – 6448ExtracellularSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence AnalysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence AnalysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence AnalysisAdd
BLAST
Transmembranei485 – 50521HelicalSequence AnalysisAdd
BLAST
Transmembranei511 – 53121HelicalSequence AnalysisAdd
BLAST
Transmembranei550 – 57021HelicalSequence AnalysisAdd
BLAST
Transmembranei581 – 60121HelicalSequence AnalysisAdd
BLAST
Transmembranei616 – 63621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati149 – 18941Alpha-1Add
BLAST
Repeati518 – 54932Alpha-2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi422 – 4287Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0530.
GeneTreeiENSGT00760000119209.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ9HC58.
KOiK13751.
OMAiQVSWWES.
OrthoDBiEOG776SP8.
PhylomeDBiQ9HC58.
TreeFamiTF318759.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HC58-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPSGDEDRA RRRRRRRRRR DLLLSQLCFL ASVALLLWSL SSLREQKELD
60 70 80 90 100
LMDLVGEDRK WMMARKLMQV NDTLTSEDAG LRNSKNCTEP ALHEFPNDIF
110 120 130 140 150
TNEDRRQGAV VLHVLCAIYM FYALAIVCDD FFVPSLEKIC ERLHLSEDVA
160 170 180 190 200
GATFMAAGSS APELFTSVIG VFITKGDVGV GTIVGSAVFN ILCIIGVCGL
210 220 230 240 250
FAGQVVALSS WCLLRDSIYY TLSVIALIVF IYDEKVSWWE SLVLVLMYLI
260 270 280 290 300
YIVIMKYNAC IHQCFERRTK GAGNMVNGLA NNAEIDDSSN CDATVVLLKK
310 320 330 340 350
ANFHRKASVI MVDELLSAYP HQLSFSEAGL RIMITSHFPP KTRLSMASRM
360 370 380 390 400
LINERQRLIN SRAYTNGESE VAIKIPIKHT VENGTGPSSA PDRGVNGTRR
410 420 430 440 450
DDVVAEAGNE TENENEDNEN DEEEEEDEDD DEGPYTPFDT PSGKLETVKW
460 470 480 490 500
AFTWPLSFVL YFTVPNCNKP RWEKWFMVTF ASSTLWIAAF SYMMVWMVTI
510 520 530 540 550
IGYTLGIPDV IMGITFLAAG TSVPDCMASL IVARQGMGDM AVSNSIGSNV
560 570 580 590 600
FDILIGLGLP WALQTLAVDY GSYIRLNSRG LIYSVGLLLA SVFVTVFGVH
610 620 630 640
LNKWQLDKKL GCGCLLLYGV FLCFSIMTEF NVFTFVNLPM CGDH
Length:644
Mass (Da):71,992
Last modified:October 17, 2006 - v4
Checksum:i84247571AC2EEE7B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491L → P.
Corresponds to variant rs3790174 [ dbSNP | Ensembl ].
VAR_028024
Natural varianti55 – 551V → I.1 Publication
Corresponds to variant rs1569767 [ dbSNP | Ensembl ].
VAR_028025
Natural varianti168 – 1681V → I.
Corresponds to variant rs3790267 [ dbSNP | Ensembl ].
VAR_028026
Natural varianti271 – 2711G → S.
Corresponds to variant rs6136807 [ dbSNP | Ensembl ].
VAR_028027

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF288087 mRNA. No translation available.
AF169257 mRNA. Translation: AAG12988.2.
AL121830
, AL034425, AL049647, AL121761, AL136090, AL139429 Genomic DNA. Translation: CAC36052.2.
AL049647
, AL034425, AL121761, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC36050.2.
AL034425
, AL049647, AL121761, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC36051.2.
AL121761
, AL034425, AL049647, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC12640.2.
AL139429
, AL034425, AL049647, AL121761, AL121830, AL136090 Genomic DNA. Translation: CAC13155.2.
AL136090
, AL034425, AL049647, AL121761, AL121830, AL139429 Genomic DNA. Translation: CAI17163.1.
CCDSiCCDS13140.1.
RefSeqiNP_065740.2. NM_020689.3.
UniGeneiHs.654790.

Genome annotation databases

EnsembliENST00000328041; ENSP00000333519; ENSG00000185052.
ENST00000613834; ENSP00000482967; ENSG00000185052.
GeneIDi57419.
KEGGihsa:57419.
UCSCiuc002wrl.3. human.

Polymorphism databases

DMDMi116242671.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF288087 mRNA. No translation available.
AF169257 mRNA. Translation: AAG12988.2 .
AL121830
, AL034425 , AL049647 , AL121761 , AL136090 , AL139429 Genomic DNA. Translation: CAC36052.2 .
AL049647
, AL034425 , AL121761 , AL121830 , AL136090 , AL139429 Genomic DNA. Translation: CAC36050.2 .
AL034425
, AL049647 , AL121761 , AL121830 , AL136090 , AL139429 Genomic DNA. Translation: CAC36051.2 .
AL121761
, AL034425 , AL049647 , AL121830 , AL136090 , AL139429 Genomic DNA. Translation: CAC12640.2 .
AL139429
, AL034425 , AL049647 , AL121761 , AL121830 , AL136090 Genomic DNA. Translation: CAC13155.2 .
AL136090
, AL034425 , AL049647 , AL121761 , AL121830 , AL139429 Genomic DNA. Translation: CAI17163.1 .
CCDSi CCDS13140.1.
RefSeqi NP_065740.2. NM_020689.3.
UniGenei Hs.654790.

3D structure databases

ProteinModelPortali Q9HC58.
SMRi Q9HC58. Positions 130-252, 501-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000333519.

Protein family/group databases

TCDBi 2.A.19.4.10. the ca(2+):cation antiporter (caca) family.

PTM databases

PhosphoSitei Q9HC58.

Polymorphism databases

DMDMi 116242671.

Proteomic databases

PaxDbi Q9HC58.
PRIDEi Q9HC58.

Protocols and materials databases

DNASUi 57419.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328041 ; ENSP00000333519 ; ENSG00000185052 .
ENST00000613834 ; ENSP00000482967 ; ENSG00000185052 .
GeneIDi 57419.
KEGGi hsa:57419.
UCSCi uc002wrl.3. human.

Organism-specific databases

CTDi 57419.
GeneCardsi GC20P019141.
H-InvDB HIX0040511.
HGNCi HGNC:10977. SLC24A3.
HPAi HPA043400.
HPA045497.
MIMi 609839. gene.
neXtProti NX_Q9HC58.
PharmGKBi PA35853.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0530.
GeneTreei ENSGT00760000119209.
HOGENOMi HOG000231933.
HOVERGENi HBG054881.
InParanoidi Q9HC58.
KOi K13751.
OMAi QVSWWES.
OrthoDBi EOG776SP8.
PhylomeDBi Q9HC58.
TreeFami TF318759.

Enzyme and pathway databases

Reactomei REACT_19320. Sodium/Calcium exchangers.

Miscellaneous databases

GenomeRNAii 57419.
NextBioi 63566.
PROi Q9HC58.
SOURCEi Search...

Gene expression databases

Bgeei Q9HC58.
CleanExi HS_SLC24A3.
Genevestigatori Q9HC58.

Family and domain databases

InterProi IPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
[Graphical view ]
PANTHERi PTHR10846. PTHR10846. 1 hit.
Pfami PF01699. Na_Ca_ex. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00367. TIGR00367. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3."
    Kraev A., Quednau B.D., Leach S., Li X.-F., Dong H., Winkfein R., Perizzolo M., Cai X., Yang R., Philipson K.D., Lytton J.
    J. Biol. Chem. 276:23161-23172(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-55.
    Tissue: Brain and Skeletal muscle.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNCKX3_HUMAN
AccessioniPrimary (citable) accession number: Q9HC58
Secondary accession number(s): B1AKV7
, Q9BQJ9, Q9BQL7, Q9BQY3, Q9H519
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3