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Q9HC58

- NCKX3_HUMAN

UniProt

Q9HC58 - NCKX3_HUMAN

Protein

Sodium/potassium/calcium exchanger 3

Gene

SLC24A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 4 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.By similarity

    GO - Molecular functioni

    1. calcium, potassium:sodium antiporter activity Source: Ensembl
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. ion transport Source: Reactome
    2. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Antiport, Calcium transport, Ion transport, Potassium transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Calcium, Potassium, Sodium

    Enzyme and pathway databases

    ReactomeiREACT_19320. Sodium/Calcium exchangers.

    Protein family/group databases

    TCDBi2.A.19.4.10. the ca(2+):cation antiporter (caca) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium/calcium exchanger 3
    Alternative name(s):
    Na(+)/K(+)/Ca(2+)-exchange protein 3
    Solute carrier family 24 member 3
    Gene namesi
    Name:SLC24A3
    Synonyms:NCKX3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:10977. SLC24A3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35853.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4444Sequence AnalysisAdd
    BLAST
    Chaini45 – 644600Sodium/potassium/calcium exchanger 3PRO_0000019370Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9HC58.
    PRIDEiQ9HC58.

    PTM databases

    PhosphoSiteiQ9HC58.

    Expressioni

    Tissue specificityi

    Abundant in the brain. Expressed at low levels in the aorta, uterus and intestine.

    Gene expression databases

    BgeeiQ9HC58.
    CleanExiHS_SLC24A3.
    GenevestigatoriQ9HC58.

    Organism-specific databases

    HPAiHPA043400.
    HPA045497.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000333519.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HC58.
    SMRiQ9HC58. Positions 130-252, 501-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini45 – 10763ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini129 – 15325CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini175 – 1828ExtracellularSequence Analysis
    Topological domaini204 – 2107CytoplasmicSequence Analysis
    Topological domaini232 – 2343ExtracellularSequence Analysis
    Topological domaini256 – 484229CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini506 – 5105ExtracellularSequence Analysis
    Topological domaini532 – 54918CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini571 – 58010ExtracellularSequence Analysis
    Topological domaini602 – 61514CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini637 – 6448ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei211 – 23121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei485 – 50521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei511 – 53121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei550 – 57021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei581 – 60121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei616 – 63621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati149 – 18941Alpha-1Add
    BLAST
    Repeati518 – 54932Alpha-2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi422 – 4287Poly-Glu

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0530.
    HOGENOMiHOG000231933.
    HOVERGENiHBG054881.
    InParanoidiQ9HC58.
    KOiK13751.
    OMAiQVSWWES.
    OrthoDBiEOG776SP8.
    PhylomeDBiQ9HC58.
    TreeFamiTF318759.

    Family and domain databases

    InterProiIPR004481. K/Na/Ca-exchanger.
    IPR004837. NaCa_Exmemb.
    [Graphical view]
    PANTHERiPTHR10846. PTHR10846. 1 hit.
    PfamiPF01699. Na_Ca_ex. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9HC58-1 [UniParc]FASTAAdd to Basket

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    MRPSGDEDRA RRRRRRRRRR DLLLSQLCFL ASVALLLWSL SSLREQKELD    50
    LMDLVGEDRK WMMARKLMQV NDTLTSEDAG LRNSKNCTEP ALHEFPNDIF 100
    TNEDRRQGAV VLHVLCAIYM FYALAIVCDD FFVPSLEKIC ERLHLSEDVA 150
    GATFMAAGSS APELFTSVIG VFITKGDVGV GTIVGSAVFN ILCIIGVCGL 200
    FAGQVVALSS WCLLRDSIYY TLSVIALIVF IYDEKVSWWE SLVLVLMYLI 250
    YIVIMKYNAC IHQCFERRTK GAGNMVNGLA NNAEIDDSSN CDATVVLLKK 300
    ANFHRKASVI MVDELLSAYP HQLSFSEAGL RIMITSHFPP KTRLSMASRM 350
    LINERQRLIN SRAYTNGESE VAIKIPIKHT VENGTGPSSA PDRGVNGTRR 400
    DDVVAEAGNE TENENEDNEN DEEEEEDEDD DEGPYTPFDT PSGKLETVKW 450
    AFTWPLSFVL YFTVPNCNKP RWEKWFMVTF ASSTLWIAAF SYMMVWMVTI 500
    IGYTLGIPDV IMGITFLAAG TSVPDCMASL IVARQGMGDM AVSNSIGSNV 550
    FDILIGLGLP WALQTLAVDY GSYIRLNSRG LIYSVGLLLA SVFVTVFGVH 600
    LNKWQLDKKL GCGCLLLYGV FLCFSIMTEF NVFTFVNLPM CGDH 644
    Length:644
    Mass (Da):71,992
    Last modified:October 17, 2006 - v4
    Checksum:i84247571AC2EEE7B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti49 – 491L → P.
    Corresponds to variant rs3790174 [ dbSNP | Ensembl ].
    VAR_028024
    Natural varianti55 – 551V → I.1 Publication
    Corresponds to variant rs1569767 [ dbSNP | Ensembl ].
    VAR_028025
    Natural varianti168 – 1681V → I.
    Corresponds to variant rs3790267 [ dbSNP | Ensembl ].
    VAR_028026
    Natural varianti271 – 2711G → S.
    Corresponds to variant rs6136807 [ dbSNP | Ensembl ].
    VAR_028027

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288087 mRNA. No translation available.
    AF169257 mRNA. Translation: AAG12988.2.
    AL121830
    , AL034425, AL049647, AL121761, AL136090, AL139429 Genomic DNA. Translation: CAC36052.2.
    AL049647
    , AL034425, AL121761, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC36050.2.
    AL034425
    , AL049647, AL121761, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC36051.2.
    AL121761
    , AL034425, AL049647, AL121830, AL136090, AL139429 Genomic DNA. Translation: CAC12640.2.
    AL139429
    , AL034425, AL049647, AL121761, AL121830, AL136090 Genomic DNA. Translation: CAC13155.2.
    AL136090
    , AL034425, AL049647, AL121761, AL121830, AL139429 Genomic DNA. Translation: CAI17163.1.
    CCDSiCCDS13140.1.
    RefSeqiNP_065740.2. NM_020689.3.
    UniGeneiHs.654790.

    Genome annotation databases

    EnsembliENST00000328041; ENSP00000333519; ENSG00000185052.
    GeneIDi57419.
    KEGGihsa:57419.
    UCSCiuc002wrl.3. human.

    Polymorphism databases

    DMDMi116242671.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288087 mRNA. No translation available.
    AF169257 mRNA. Translation: AAG12988.2 .
    AL121830
    , AL034425 , AL049647 , AL121761 , AL136090 , AL139429 Genomic DNA. Translation: CAC36052.2 .
    AL049647
    , AL034425 , AL121761 , AL121830 , AL136090 , AL139429 Genomic DNA. Translation: CAC36050.2 .
    AL034425
    , AL049647 , AL121761 , AL121830 , AL136090 , AL139429 Genomic DNA. Translation: CAC36051.2 .
    AL121761
    , AL034425 , AL049647 , AL121830 , AL136090 , AL139429 Genomic DNA. Translation: CAC12640.2 .
    AL139429
    , AL034425 , AL049647 , AL121761 , AL121830 , AL136090 Genomic DNA. Translation: CAC13155.2 .
    AL136090
    , AL034425 , AL049647 , AL121761 , AL121830 , AL139429 Genomic DNA. Translation: CAI17163.1 .
    CCDSi CCDS13140.1.
    RefSeqi NP_065740.2. NM_020689.3.
    UniGenei Hs.654790.

    3D structure databases

    ProteinModelPortali Q9HC58.
    SMRi Q9HC58. Positions 130-252, 501-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000333519.

    Protein family/group databases

    TCDBi 2.A.19.4.10. the ca(2+):cation antiporter (caca) family.

    PTM databases

    PhosphoSitei Q9HC58.

    Polymorphism databases

    DMDMi 116242671.

    Proteomic databases

    PaxDbi Q9HC58.
    PRIDEi Q9HC58.

    Protocols and materials databases

    DNASUi 57419.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328041 ; ENSP00000333519 ; ENSG00000185052 .
    GeneIDi 57419.
    KEGGi hsa:57419.
    UCSCi uc002wrl.3. human.

    Organism-specific databases

    CTDi 57419.
    GeneCardsi GC20P019141.
    H-InvDB HIX0040511.
    HGNCi HGNC:10977. SLC24A3.
    HPAi HPA043400.
    HPA045497.
    MIMi 609839. gene.
    neXtProti NX_Q9HC58.
    PharmGKBi PA35853.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0530.
    HOGENOMi HOG000231933.
    HOVERGENi HBG054881.
    InParanoidi Q9HC58.
    KOi K13751.
    OMAi QVSWWES.
    OrthoDBi EOG776SP8.
    PhylomeDBi Q9HC58.
    TreeFami TF318759.

    Enzyme and pathway databases

    Reactomei REACT_19320. Sodium/Calcium exchangers.

    Miscellaneous databases

    GenomeRNAii 57419.
    NextBioi 63566.
    PROi Q9HC58.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9HC58.
    CleanExi HS_SLC24A3.
    Genevestigatori Q9HC58.

    Family and domain databases

    InterProi IPR004481. K/Na/Ca-exchanger.
    IPR004837. NaCa_Exmemb.
    [Graphical view ]
    PANTHERi PTHR10846. PTHR10846. 1 hit.
    Pfami PF01699. Na_Ca_ex. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00367. TIGR00367. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3."
      Kraev A., Quednau B.D., Leach S., Li X.-F., Dong H., Winkfein R., Perizzolo M., Cai X., Yang R., Philipson K.D., Lytton J.
      J. Biol. Chem. 276:23161-23172(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-55.
      Tissue: Brain and Skeletal muscle.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiNCKX3_HUMAN
    AccessioniPrimary (citable) accession number: Q9HC58
    Secondary accession number(s): B1AKV7
    , Q9BQJ9, Q9BQL7, Q9BQY3, Q9H519
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 13, 2001
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 119 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3