Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WAP four-disulfide core domain protein 1

Gene

WFDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has growth inhibitory activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103175-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 1
Alternative name(s):
Prostate stromal protein ps20
ps20 growth inhibitor
Gene namesi
Name:WFDC1
Synonyms:PS20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:15466. WFDC1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi58189.
OpenTargetsiENSG00000103175.
PharmGKBiPA37963.

Polymorphism and mutation databases

BioMutaiWFDC1.
DMDMi22096244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000004136532 – 220WAP four-disulfide core domain protein 1Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi66 ↔ 96PROSITE-ProRule annotation
Disulfide bondi78 ↔ 100PROSITE-ProRule annotation
Disulfide bondi83 ↔ 95PROSITE-ProRule annotation
Disulfide bondi89 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9HC57.
PeptideAtlasiQ9HC57.
PRIDEiQ9HC57.

PTM databases

iPTMnetiQ9HC57.
PhosphoSitePlusiQ9HC57.

Expressioni

Gene expression databases

BgeeiENSG00000103175.
CleanExiHS_WFDC1.
ExpressionAtlasiQ9HC57. baseline and differential.
GenevisibleiQ9HC57. HS.

Organism-specific databases

HPAiHPA031411.

Interactioni

Protein-protein interaction databases

BioGridi121803. 7 interactors.
IntActiQ9HC57. 5 interactors.
STRINGi9606.ENSP00000219454.

Structurei

3D structure databases

ProteinModelPortaliQ9HC57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 108WAPPROSITE-ProRule annotationAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 70Poly-Pro4
Compositional biasi109 – 112Poly-Pro4

Sequence similaritiesi

Contains 1 WAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH18. Eukaryota.
ENOG41106Q5. LUCA.
GeneTreeiENSGT00390000014299.
HOGENOMiHOG000290176.
HOVERGENiHBG075889.
InParanoidiQ9HC57.
OMAiLRHKYFK.
OrthoDBiEOG091G0I2U.
PhylomeDBiQ9HC57.
TreeFamiTF328768.

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiIPR008197. WAP_dom.
[Graphical view]
PfamiPF00095. WAP. 1 hit.
[Graphical view]
SMARTiSM00217. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiPS51390. WAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HC57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLTGVGPGS CRRQIIRALC LLLLLLHAGS AKNIWKRALP ARLAEKSRAE
60 70 80 90 100
EAGAPGGPRQ PRADRCPPPP RTLPPGACQA ARCQADSECP RHRRCCYNGC
110 120 130 140 150
AYACLEAVPP PPVLDWLVQP KPRWLGGNGW LLDGPEEVLQ AEACSTTEDG
160 170 180 190 200
AEPLLCPSGY ECHILSPGDV AEGIPNRGQC VKQRRQADGR ILRHKLYKEY
210 220
PEGDSKNVAE PGRGQQKHFQ
Length:220
Mass (Da):23,977
Last modified:August 2, 2002 - v2
Checksum:i8098EB9379F88CBD
GO

Sequence cautioni

The sequence AAG15263 differs from that shown. Reason: Frameshift at positions 166 and 173.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33N → D in BAC11377 (PubMed:14702039).Curated1
Sequence conflicti79Q → R in BAC11377 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036489138V → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs11643870dbSNPEnsembl.1
Natural variantiVAR_052948196L → V.Corresponds to variant rs35504166dbSNPEnsembl.1
Natural variantiVAR_052949217K → R.2 PublicationsCorresponds to variant rs12933084dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169631 mRNA. Translation: AAG16647.1.
AF302109 mRNA. Translation: AAG15263.1. Frameshift.
AK075061 mRNA. Translation: BAC11377.1.
CH471114 Genomic DNA. Translation: EAW95486.1.
CH471114 Genomic DNA. Translation: EAW95487.1.
BC029159 mRNA. Translation: AAH29159.1.
CCDSiCCDS10946.1.
RefSeqiNP_001269395.1. NM_001282466.1.
NP_001269396.1. NM_001282467.1.
NP_067020.2. NM_021197.3.
UniGeneiHs.36688.

Genome annotation databases

EnsembliENST00000219454; ENSP00000219454; ENSG00000103175.
ENST00000568638; ENSP00000456920; ENSG00000103175.
GeneIDi58189.
KEGGihsa:58189.
UCSCiuc002fhv.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169631 mRNA. Translation: AAG16647.1.
AF302109 mRNA. Translation: AAG15263.1. Frameshift.
AK075061 mRNA. Translation: BAC11377.1.
CH471114 Genomic DNA. Translation: EAW95486.1.
CH471114 Genomic DNA. Translation: EAW95487.1.
BC029159 mRNA. Translation: AAH29159.1.
CCDSiCCDS10946.1.
RefSeqiNP_001269395.1. NM_001282466.1.
NP_001269396.1. NM_001282467.1.
NP_067020.2. NM_021197.3.
UniGeneiHs.36688.

3D structure databases

ProteinModelPortaliQ9HC57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121803. 7 interactors.
IntActiQ9HC57. 5 interactors.
STRINGi9606.ENSP00000219454.

PTM databases

iPTMnetiQ9HC57.
PhosphoSitePlusiQ9HC57.

Polymorphism and mutation databases

BioMutaiWFDC1.
DMDMi22096244.

Proteomic databases

PaxDbiQ9HC57.
PeptideAtlasiQ9HC57.
PRIDEiQ9HC57.

Protocols and materials databases

DNASUi58189.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219454; ENSP00000219454; ENSG00000103175.
ENST00000568638; ENSP00000456920; ENSG00000103175.
GeneIDi58189.
KEGGihsa:58189.
UCSCiuc002fhv.5. human.

Organism-specific databases

CTDi58189.
DisGeNETi58189.
GeneCardsiWFDC1.
HGNCiHGNC:15466. WFDC1.
HPAiHPA031411.
MIMi605322. gene.
neXtProtiNX_Q9HC57.
OpenTargetsiENSG00000103175.
PharmGKBiPA37963.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH18. Eukaryota.
ENOG41106Q5. LUCA.
GeneTreeiENSGT00390000014299.
HOGENOMiHOG000290176.
HOVERGENiHBG075889.
InParanoidiQ9HC57.
OMAiLRHKYFK.
OrthoDBiEOG091G0I2U.
PhylomeDBiQ9HC57.
TreeFamiTF328768.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103175-MONOMER.

Miscellaneous databases

GeneWikiiWFDC1.
GenomeRNAii58189.
PROiQ9HC57.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103175.
CleanExiHS_WFDC1.
ExpressionAtlasiQ9HC57. baseline and differential.
GenevisibleiQ9HC57. HS.

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiIPR008197. WAP_dom.
[Graphical view]
PfamiPF00095. WAP. 1 hit.
[Graphical view]
SMARTiSM00217. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiPS51390. WAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWFDC1_HUMAN
AccessioniPrimary (citable) accession number: Q9HC57
Secondary accession number(s): D3DUL7, Q8NC27, Q9HAU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.