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Protein

WAP four-disulfide core domain protein 1

Gene

WFDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has growth inhibitory activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 1
Alternative name(s):
Prostate stromal protein ps20
ps20 growth inhibitor
Gene namesi
Name:WFDC1
Synonyms:PS20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:15466. WFDC1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37963.

Polymorphism and mutation databases

BioMutaiWFDC1.
DMDMi22096244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 220189WAP four-disulfide core domain protein 1PRO_0000041365Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi66 ↔ 96PROSITE-ProRule annotation
Disulfide bondi78 ↔ 100PROSITE-ProRule annotation
Disulfide bondi83 ↔ 95PROSITE-ProRule annotation
Disulfide bondi89 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9HC57.
PeptideAtlasiQ9HC57.
PRIDEiQ9HC57.

PTM databases

iPTMnetiQ9HC57.

Expressioni

Gene expression databases

BgeeiQ9HC57.
CleanExiHS_WFDC1.
ExpressionAtlasiQ9HC57. baseline and differential.
GenevisibleiQ9HC57. HS.

Organism-specific databases

HPAiHPA031411.

Interactioni

Protein-protein interaction databases

BioGridi121803. 7 interactions.
IntActiQ9HC57. 5 interactions.
STRINGi9606.ENSP00000219454.

Structurei

3D structure databases

ProteinModelPortaliQ9HC57.
SMRiQ9HC57. Positions 62-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 10850WAPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi67 – 704Poly-Pro
Compositional biasi109 – 1124Poly-Pro

Sequence similaritiesi

Contains 1 WAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH18. Eukaryota.
ENOG41106Q5. LUCA.
GeneTreeiENSGT00390000014299.
HOGENOMiHOG000290176.
HOVERGENiHBG075889.
InParanoidiQ9HC57.
OMAiLRHKYFK.
OrthoDBiEOG7MH10B.
PhylomeDBiQ9HC57.
TreeFamiTF328768.

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiIPR008197. WAP_dom.
[Graphical view]
PfamiPF00095. WAP. 1 hit.
[Graphical view]
SMARTiSM00217. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiPS51390. WAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HC57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLTGVGPGS CRRQIIRALC LLLLLLHAGS AKNIWKRALP ARLAEKSRAE
60 70 80 90 100
EAGAPGGPRQ PRADRCPPPP RTLPPGACQA ARCQADSECP RHRRCCYNGC
110 120 130 140 150
AYACLEAVPP PPVLDWLVQP KPRWLGGNGW LLDGPEEVLQ AEACSTTEDG
160 170 180 190 200
AEPLLCPSGY ECHILSPGDV AEGIPNRGQC VKQRRQADGR ILRHKLYKEY
210 220
PEGDSKNVAE PGRGQQKHFQ
Length:220
Mass (Da):23,977
Last modified:August 2, 2002 - v2
Checksum:i8098EB9379F88CBD
GO

Sequence cautioni

The sequence AAG15263.1 differs from that shown. Reason: Frameshift at positions 166 and 173. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331N → D in BAC11377 (PubMed:14702039).Curated
Sequence conflicti79 – 791Q → R in BAC11377 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti138 – 1381V → M in a breast cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs11643870 [ dbSNP | Ensembl ].
VAR_036489
Natural varianti196 – 1961L → V.
Corresponds to variant rs35504166 [ dbSNP | Ensembl ].
VAR_052948
Natural varianti217 – 2171K → R.2 Publications
Corresponds to variant rs12933084 [ dbSNP | Ensembl ].
VAR_052949

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169631 mRNA. Translation: AAG16647.1.
AF302109 mRNA. Translation: AAG15263.1. Frameshift.
AK075061 mRNA. Translation: BAC11377.1.
CH471114 Genomic DNA. Translation: EAW95486.1.
CH471114 Genomic DNA. Translation: EAW95487.1.
BC029159 mRNA. Translation: AAH29159.1.
CCDSiCCDS10946.1.
RefSeqiNP_001269395.1. NM_001282466.1.
NP_001269396.1. NM_001282467.1.
NP_067020.2. NM_021197.3.
UniGeneiHs.36688.

Genome annotation databases

EnsembliENST00000219454; ENSP00000219454; ENSG00000103175.
ENST00000568638; ENSP00000456920; ENSG00000103175.
GeneIDi58189.
KEGGihsa:58189.
UCSCiuc002fhv.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169631 mRNA. Translation: AAG16647.1.
AF302109 mRNA. Translation: AAG15263.1. Frameshift.
AK075061 mRNA. Translation: BAC11377.1.
CH471114 Genomic DNA. Translation: EAW95486.1.
CH471114 Genomic DNA. Translation: EAW95487.1.
BC029159 mRNA. Translation: AAH29159.1.
CCDSiCCDS10946.1.
RefSeqiNP_001269395.1. NM_001282466.1.
NP_001269396.1. NM_001282467.1.
NP_067020.2. NM_021197.3.
UniGeneiHs.36688.

3D structure databases

ProteinModelPortaliQ9HC57.
SMRiQ9HC57. Positions 62-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121803. 7 interactions.
IntActiQ9HC57. 5 interactions.
STRINGi9606.ENSP00000219454.

PTM databases

iPTMnetiQ9HC57.

Polymorphism and mutation databases

BioMutaiWFDC1.
DMDMi22096244.

Proteomic databases

PaxDbiQ9HC57.
PeptideAtlasiQ9HC57.
PRIDEiQ9HC57.

Protocols and materials databases

DNASUi58189.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219454; ENSP00000219454; ENSG00000103175.
ENST00000568638; ENSP00000456920; ENSG00000103175.
GeneIDi58189.
KEGGihsa:58189.
UCSCiuc002fhv.5. human.

Organism-specific databases

CTDi58189.
GeneCardsiWFDC1.
HGNCiHGNC:15466. WFDC1.
HPAiHPA031411.
MIMi605322. gene.
neXtProtiNX_Q9HC57.
PharmGKBiPA37963.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH18. Eukaryota.
ENOG41106Q5. LUCA.
GeneTreeiENSGT00390000014299.
HOGENOMiHOG000290176.
HOVERGENiHBG075889.
InParanoidiQ9HC57.
OMAiLRHKYFK.
OrthoDBiEOG7MH10B.
PhylomeDBiQ9HC57.
TreeFamiTF328768.

Miscellaneous databases

GeneWikiiWFDC1.
GenomeRNAii58189.
PROiQ9HC57.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HC57.
CleanExiHS_WFDC1.
ExpressionAtlasiQ9HC57. baseline and differential.
GenevisibleiQ9HC57. HS.

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiIPR008197. WAP_dom.
[Graphical view]
PfamiPF00095. WAP. 1 hit.
[Graphical view]
SMARTiSM00217. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiPS51390. WAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers."
    Larsen M., Ressler S.J., Gerdes M.J., Lu B., Byron M., Lawrence J.B., Rowley D.R.
    Mamm. Genome 11:767-773(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-217.
    Tissue: Prostate.
  2. "Molecular cloning and characterization of the human ps20 protein in human uterus."
    Ong C.K., Ng C.Y., Lim K.B., Chan T.W.M.G., Huynh H.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Uterus.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-217.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon, Kidney and Stomach.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-138.

Entry informationi

Entry nameiWFDC1_HUMAN
AccessioniPrimary (citable) accession number: Q9HC57
Secondary accession number(s): D3DUL7, Q8NC27, Q9HAU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: July 6, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.