Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9HC57 (WFDC1_HUMAN)

Last modified June 16, 2009. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    WAP four-disulfide core domain protein 1
Alternative name(s):
    Prostate stromal protein ps20
    ps20 growth inhibitor
Gene names
Name: WFDC1
Synonyms: PS20
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Has growth inhibitory activity By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Contains 1 WAP domain.

Sequence caution

The sequence AAG15263.1 differs from that shown. Reason: Frameshift at positions 166 and 173.

Hide | Top

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMDisulfide bond
Gene Ontology (GO)
   Biological processnegative regulation of cell growth Ref.1

Non-traceable author statement. Source: UniProtKB

   Cellular componentextracellular space Ref.1

Non-traceable author statement. Source: UniProtKB

   Molecular functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 220189WAP four-disulfide core domain protein 1
PRO_0000041365

Regions

Domain59 – 10850WAP
Compositional bias67 – 704Poly-Pro
Compositional bias109 – 1124Poly-Pro

Amino acid modifications

Disulfide bond66 ↔ 96 By similarity
Disulfide bond78 ↔ 100 By similarity
Disulfide bond83 ↔ 95 By similarity
Disulfide bond89 ↔ 104 By similarity

Natural variations

Natural variant1381V → M in a breast cancer sample; somatic mutation. Ref.5
VAR_036489
Natural variant1961L → V: dbSNP rs35504166.
VAR_052948
Natural variant2171K → R: dbSNP rs12933084. Ref.1
VAR_052949

Experimental info

Sequence conflict331N → D in BAC11377. Ref.3
Sequence conflict791Q → R in BAC11377. Ref.3

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q9HC57-1 [UniParc].

Last modified August 2, 2002. Version 2.
Checksum: 8098EB9379F88CBD

FASTA22023,977
        10         20         30         40         50         60 
MPLTGVGPGS CRRQIIRALC LLLLLLHAGS AKNIWKRALP ARLAEKSRAE EAGAPGGPRQ 

        70         80         90        100        110        120 
PRADRCPPPP RTLPPGACQA ARCQADSECP RHRRCCYNGC AYACLEAVPP PPVLDWLVQP 

       130        140        150        160        170        180 
KPRWLGGNGW LLDGPEEVLQ AEACSTTEDG AEPLLCPSGY ECHILSPGDV AEGIPNRGQC 

       190        200        210        220 
VKQRRQADGR ILRHKLYKEY PEGDSKNVAE PGRGQQKHFQ

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers."
Larsen M., Ressler S.J., Gerdes M.J., Lu B., Byron M., Lawrence J.B., Rowley D.R.
Mamm. Genome 11:767-773(2000) [PubMed: 10967136] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-217.
Tissue: Prostate.
[2]"Molecular cloning and characterization of the human ps20 protein in human uterus."
Ong C.K., Ng C.Y., Lim K.B., Chan T.W.M.G., Huynh H.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Uterus.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon, Kidney and Stomach.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed: 16959974] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-138.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

AF169631 mRNA. Translation: AAG16647.1.
AF302109 mRNA. Translation: AAG15263.1. Frameshift.
AK075061 mRNA. Translation: BAC11377.1.
BC029159 mRNA. Translation: AAH29159.1.
IPIIPI00008997.
RefSeqNP_067020.2.
UniGeneHs.36688

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSG00000103175. Homo sapiens. [Contig view]
GeneID58189.
KEGGhsa:58189.

Organism-specific databases

GeneCardsGC16P082885.
H-InvDBHIX0013294.
HGNCHGNC:15466. WFDC1.
MIM605322. gene.
PharmGKBPA37963.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9HC57.
HOVERGENQ9HC57.
OMAQ9HC57. AVRCQAD.

Gene expression databases

ArrayExpressQ9HC57.
BgeeQ9HC57.
CleanExHS_WFDC1.
GermOnlineENSG00000103175. Homo sapiens.

Family and domain databases

InterProIPR018069. Whey_acidic_4-diS_core_CS.
IPR008197. Whey_acidic_protein_4-diS_core.
[Graphical view]
PfamPF00095. WAP. 1 hit.
[Graphical view]
SMARTSM00217. WAP. 1 hit.
[Graphical view]
PROSITEPS51390. WAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio64880.
SOURCESearch...

Hide | Top

Entry information

Entry nameWFDC1_HUMAN
AccessionPrimary (citable) accession number: Q9HC57
Secondary accession number(s): Q8NC27, Q9HAU1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: June 16, 2009
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents