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Q9HC57 (WFDC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WAP four-disulfide core domain protein 1
Alternative name(s):
Prostate stromal protein ps20
ps20 growth inhibitor
Gene names
Name:WFDC1
Synonyms:PS20
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has growth inhibitory activity By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Contains 1 WAP domain.

Sequence caution

The sequence AAG15263.1 differs from that shown. Reason: Frameshift at positions 166 and 173.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processnegative regulation of cell growth

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular componentextracellular space

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 220189WAP four-disulfide core domain protein 1
PRO_0000041365

Regions

Domain59 – 10850WAP
Compositional bias67 – 704Poly-Pro
Compositional bias109 – 1124Poly-Pro

Amino acid modifications

Disulfide bond66 ↔ 96 By similarity
Disulfide bond78 ↔ 100 By similarity
Disulfide bond83 ↔ 95 By similarity
Disulfide bond89 ↔ 104 By similarity

Natural variations

Natural variant1381V → M in a breast cancer sample; somatic mutation. Ref.6
Corresponds to variant rs11643870 [ dbSNP | Ensembl ].
VAR_036489
Natural variant1961L → V.
Corresponds to variant rs35504166 [ dbSNP | Ensembl ].
VAR_052948
Natural variant2171K → R. Ref.1 Ref.4
Corresponds to variant rs12933084 [ dbSNP | Ensembl ].
VAR_052949

Experimental info

Sequence conflict331N → D in BAC11377. Ref.3
Sequence conflict791Q → R in BAC11377. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9HC57 [UniParc].

Last modified August 2, 2002. Version 2.
Checksum: 8098EB9379F88CBD

FASTA22023,977
        10         20         30         40         50         60 
MPLTGVGPGS CRRQIIRALC LLLLLLHAGS AKNIWKRALP ARLAEKSRAE EAGAPGGPRQ 

        70         80         90        100        110        120 
PRADRCPPPP RTLPPGACQA ARCQADSECP RHRRCCYNGC AYACLEAVPP PPVLDWLVQP 

       130        140        150        160        170        180 
KPRWLGGNGW LLDGPEEVLQ AEACSTTEDG AEPLLCPSGY ECHILSPGDV AEGIPNRGQC 

       190        200        210        220 
VKQRRQADGR ILRHKLYKEY PEGDSKNVAE PGRGQQKHFQ 

« Hide

References

« Hide 'large scale' references
[1]"The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers."
Larsen M., Ressler S.J., Gerdes M.J., Lu B., Byron M., Lawrence J.B., Rowley D.R.
Mamm. Genome 11:767-773(2000) [PubMed: 10967136] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-217.
Tissue: Prostate.
[2]"Molecular cloning and characterization of the human ps20 protein in human uterus."
Ong C.K., Ng C.Y., Lim K.B., Chan T.W.M.G., Huynh H.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Uterus.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-217.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon, Kidney and Stomach.
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed: 16959974] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-138.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF169631 mRNA. Translation: AAG16647.1.
AF302109 mRNA. Translation: AAG15263.1. Frameshift.
AK075061 mRNA. Translation: BAC11377.1.
CH471114 Genomic DNA. Translation: EAW95486.1.
CH471114 Genomic DNA. Translation: EAW95487.1.
BC029159 mRNA. Translation: AAH29159.1.
IPIIPI00008997.
RefSeqNP_067020.2. NM_021197.2.
UniGeneHs.36688.

3D structure databases

ProteinModelPortalQ9HC57.
SMRQ9HC57. Positions 61-109.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9HC57. 5 interactions.
STRINGQ9HC57.

Polymorphism databases

DMDM22096244.

Proteomic databases

PRIDEQ9HC57.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000219454; ENSP00000219454; ENSG00000103175.
GeneID58189.
KEGGhsa:58189.
UCSCuc002fhv.2. human.

Organism-specific databases

CTD58189.
GeneCardsGC16P084328.
H-InvDBHIX0013294.
HGNCHGNC:15466. WFDC1.
HPAHPA031411.
MIM605322. gene.
neXtProtNX_Q9HC57.
PharmGKBPA37963.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG04519.
GeneTreeENSGT00390000014299.
HOGENOMHBG444741.
HOVERGENHBG075889.
InParanoidQ9HC57.
OMAAVRCQAD.
OrthoDBEOG4J3WHW.
PhylomeDBQ9HC57.

Gene expression databases

ArrayExpressQ9HC57.
BgeeQ9HC57.
CleanExHS_WFDC1.
GenevestigatorQ9HC57.
GermOnlineENSG00000103175. Homo sapiens.

Family and domain databases

InterProIPR008197. Whey_acidic_protein_4-diS_core.
[Graphical view]
Gene3DG3DSA:4.10.75.10. Whey_acidic_protein_4-diS_core. 1 hit.
PfamPF00095. WAP. 1 hit.
[Graphical view]
SMARTSM00217. WAP. 1 hit.
[Graphical view]
SUPFAMSSF57256. WAP. 1 hit.
PROSITEPS51390. WAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio64880.
SOURCESearch...

Entry information

Entry nameWFDC1_HUMAN
AccessionPrimary (citable) accession number: Q9HC57
Secondary accession number(s): D3DUL7, Q8NC27, Q9HAU1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: January 25, 2012
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families