Q9HC57 (WFDC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WAP four-disulfide core domain protein 1

Alternative name(s):
Prostate stromal protein ps20
ps20 growth inhibitor

Gene names

Name:	WFDC1
Synonyms:	PS20

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has growth inhibitory activity By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Contains 1 WAP domain.
Sequence caution	The sequence AAG15263.1 differs from that shown. Reason: Frameshift at positions 166 and 173.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of cell growth Non-traceable author statement Ref.1. Source: UniProtKB
Cellular component	extracellular space Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 220	189	WAP four-disulfide core domain protein 1		PRO_0000041365
Regions
	Domain	59 – 108	50	WAP
	Compositional bias	67 – 70	4	Poly-Pro
	Compositional bias	109 – 112	4	Poly-Pro
Amino acid modifications
	Disulfide bond	66 ↔ 96		By similarity
	Disulfide bond	78 ↔ 100		By similarity
	Disulfide bond	83 ↔ 95		By similarity
	Disulfide bond	89 ↔ 104		By similarity
Natural variations
	Natural variant	138	1	V → M in a breast cancer sample; somatic mutation. Ref.6 Corresponds to variant rs11643870 [ dbSNP | Ensembl ].		VAR_036489
	Natural variant	196	1	L → V. Corresponds to variant rs35504166 [ dbSNP | Ensembl ].		VAR_052948
	Natural variant	217	1	K → R. Ref.1 Ref.4 Corresponds to variant rs12933084 [ dbSNP | Ensembl ].		VAR_052949
Experimental info
	Sequence conflict	33	1	N → D in BAC11377. Ref.3
	Sequence conflict	79	1	Q → R in BAC11377. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9HC57 [UniParc]. Last modified August 2, 2002. Version 2. Checksum: 8098EB9379F88CBD	FASTA	220	23,977
	10 20 30 40 50 60 MPLTGVGPGS CRRQIIRALC LLLLLLHAGS AKNIWKRALP ARLAEKSRAE EAGAPGGPRQ 70 80 90 100 110 120 PRADRCPPPP RTLPPGACQA ARCQADSECP RHRRCCYNGC AYACLEAVPP PPVLDWLVQP 130 140 150 160 170 180 KPRWLGGNGW LLDGPEEVLQ AEACSTTEDG AEPLLCPSGY ECHILSPGDV AEGIPNRGQC 190 200 210 220 VKQRRQADGR ILRHKLYKEY PEGDSKNVAE PGRGQQKHFQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers." Larsen M., Ressler S.J., Gerdes M.J., Lu B., Byron M., Lawrence J.B., Rowley D.R. Mamm. Genome 11:767-773(2000) [PubMed: 10967136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-217. Tissue: Prostate.
[2]	"Molecular cloning and characterization of the human ps20 protein in human uterus." Ong C.K., Ng C.Y., Lim K.B., Chan T.W.M.G., Huynh H. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Uterus.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-217.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon, Kidney and Stomach.
[6]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-138.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF169631 mRNA. Translation: AAG16647.1. AF302109 mRNA. Translation: AAG15263.1. Frameshift. AK075061 mRNA. Translation: BAC11377.1. CH471114 Genomic DNA. Translation: EAW95486.1. CH471114 Genomic DNA. Translation: EAW95487.1. BC029159 mRNA. Translation: AAH29159.1.
IPI	IPI00008997.
RefSeq	NP_067020.2. NM_021197.2.
UniGene	Hs.36688.
3D structure databases
ProteinModelPortal	Q9HC57.
SMR	Q9HC57. Positions 61-109.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HC57. 5 interactions.
STRING	Q9HC57.
Polymorphism databases
DMDM	22096244.
Proteomic databases
PRIDE	Q9HC57.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000219454; ENSP00000219454; ENSG00000103175.
GeneID	58189.
KEGG	hsa:58189.
UCSC	uc002fhv.2. human.
Organism-specific databases
CTD	58189.
GeneCards	GC16P084328.
H-InvDB	HIX0013294.
HGNC	HGNC:15466. WFDC1.
HPA	HPA031411.
MIM	605322. gene.
neXtProt	NX_Q9HC57.
PharmGKB	PA37963.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04519.
GeneTree	ENSGT00390000014299.
HOGENOM	HBG444741.
HOVERGEN	HBG075889.
InParanoid	Q9HC57.
OMA	AVRCQAD.
OrthoDB	EOG4J3WHW.
PhylomeDB	Q9HC57.
Gene expression databases
ArrayExpress	Q9HC57.
Bgee	Q9HC57.
CleanEx	HS_WFDC1.
Genevestigator	Q9HC57.
GermOnline	ENSG00000103175. Homo sapiens.
Family and domain databases
InterPro	IPR008197. Whey_acidic_protein_4-diS_core. [Graphical view]
Gene3D	G3DSA:4.10.75.10. Whey_acidic_protein_4-diS_core. 1 hit.
Pfam	PF00095. WAP. 1 hit. [Graphical view]
SMART	SM00217. WAP. 1 hit. [Graphical view]
SUPFAM	SSF57256. WAP. 1 hit.
PROSITE	PS51390. WAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	64880.
SOURCE	Search...

Entry information

Entry name

WFDC1_HUMAN

Accession

Primary (citable) accession number: Q9HC57
Secondary accession number(s): D3DUL7, Q8NC27, Q9HAU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	August 2, 2002
Last modified:	January 25, 2012
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.