Reviewed,
UniProtKB/Swiss-Prot Q9HC52 (CBX8_HUMAN)
Last modified
June 16, 2009.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Chromobox protein homolog 8 Alternative name(s): Polycomb 3 homolog Short name=Pc3 Short name=hPc3 Rectachrome 1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 389 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| Subunit structure | Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Interacts with MLLT3. Ref.5 |
| Subcellular location | |
| Sequence similarities | Contains 1 chromo domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Polymorphism |
| Molecular function | Chromatin regulator Repressor |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | chromatin assembly or disassembly Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | chromatin Inferred from electronic annotation. Source: InterPro |
| Molecular function | chromatin binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 389 | 389 | Chromobox protein homolog 8 | PRO_0000080215 | |||||
Regions | |||||||||
| Domain | 11 – 69 | 59 | Chromo | ||||||
Amino acid modifications | |||||||||
| Modified residue | 110 | 1 | Phosphoserine Ref.7 Ref.8 | ||||||
| Modified residue | 130 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 256 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 265 | 1 | Phosphoserine Ref.7 Ref.8 | ||||||
| Modified residue | 332 | 1 | Phosphoserine Ref.8 | ||||||
| Modified residue | 352 | 1 | Phosphoserine Ref.8 | ||||||
Natural variations | |||||||||
| Natural variant | 317 | 1 | G → V: dbSNP rs4889891. Ref.2 Ref.3 | VAR_014954 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties." Bardos J.I., Saurin A.J., Tissot C., Duprez E., Freemont P.S. J. Biol. Chem. 275:28785-28792(2000) [PubMed: 10825164] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Isolation of Polycomb and Trithorax-related genes that are expressed in human colorectal mucosa." Michael M.Z., James R.J. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-317. Tissue: Colon carcinoma. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-317. Tissue: Embryo. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Muscle. |
| [5] | "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3." Garcia-Cuellar M.P., Zilles O., Schreiner S.A., Birke M., Winkler T.H., Slany R.K. Oncogene 20:411-419(2001) [PubMed: 11313972] [Abstract] Cited for: INTERACTION WITH MLLT3. |
| [6] | "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans." Levine S.S., Weiss A., Erdjument-Bromage H., Shao Z., Tempst P., Kingston R.E. Mol. Cell. Biol. 22:6070-6078(2002) [PubMed: 12167701] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE PRC1 COMPLEX WITH PCGF2; BMI1; CBX2; CBX4; PHC1; PHC2; PHC3; SCMH1; RING1 AND RNF2. |
| [7] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110 AND SER-265, MASS SPECTROMETRY. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110; SER-130; SER-256; SER-265; SER-332 AND SER-352, MASS SPECTROMETRY. |
| [9] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AF174482 mRNA. Translation: AAG09180.1. AF266479 mRNA. Translation: AAF76328.2. AK074560 mRNA. Translation: BAC11061.1. BC008937 mRNA. Translation: AAH08937.1. BC009376 mRNA. Translation: AAH09376.1. BC019289 mRNA. Translation: AAH19289.1. | |
| IPI | IPI00307659. |
| RefSeq | NP_065700.1. |
| UniGene | Hs.387258 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AP0 based on UniProtKB P23197. |
| SMR | Q9HC52. Positions 7-58. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9HC52. 6 interactions. |
PTM databases | |
| PhosphoSite | Q9HC52. |
Proteomic databases | |
| PeptideAtlas | Q9HC52. |
| PRIDE | Q9HC52. |
Genome annotation databases | |
| Ensembl | ENSG00000141570. Homo sapiens. [Contig view] |
| GeneID | 57332. |
| KEGG | hsa:57332. |
Organism-specific databases | |
| GeneCards | GC17M075382. |
| H-InvDB | HIX0014234. |
| HGNC | HGNC:15962. CBX8. |
| PharmGKB | PA26133. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9HC52. |
| HOVERGEN | Q9HC52. |
| OMA | Q9HC52. RRQDSDL. |
Gene expression databases | |
| ArrayExpress | Q9HC52. |
| Bgee | Q9HC52. |
| CleanEx | HS_CBX8. |
| GermOnline | ENSG00000141570. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000953. Chromodomain. [Graphical view] |
| Pfam | PF00385. Chromo. 1 hit. [Graphical view] |
| SMART | SM00298. CHROMO. 1 hit. [Graphical view] |
| PROSITE | PS00598. CHROMO_1. 1 hit. PS50013. CHROMO_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 63438. |
Entry information
| Entry name | CBX8_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9HC52 Secondary accession number(s): Q96H39, Q9NR07 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with


