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Protein

Vasculin-like protein 1

Gene

GPBP1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible transcription factor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Vasculin-like protein 1
Alternative name(s):
GC-rich promoter-binding protein 1-like 1
Gene namesi
Name:GPBP1L1
ORF Names:SP192
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000159592.10
HGNCiHGNC:28843 GPBP1L1
neXtProtiNX_Q9HC44

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159592
PharmGKBiPA142671715

Polymorphism and mutation databases

BioMutaiGPBP1L1
DMDMi74752789

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241151 – 474Vasculin-like protein 1Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei292PhosphoserineBy similarity1
Modified residuei301PhosphothreonineCombined sources1
Modified residuei382PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HC44
MaxQBiQ9HC44
PaxDbiQ9HC44
PeptideAtlasiQ9HC44
PRIDEiQ9HC44

PTM databases

iPTMnetiQ9HC44
PhosphoSitePlusiQ9HC44

Expressioni

Gene expression databases

BgeeiENSG00000159592
CleanExiHS_GPBP1L1
GenevisibleiQ9HC44 HS

Organism-specific databases

HPAiHPA028593

Interactioni

Protein-protein interaction databases

BioGridi121896, 49 interactors
IntActiQ9HC44, 9 interactors
STRINGi9606.ENSP00000290795

Structurei

3D structure databases

ProteinModelPortaliQ9HC44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasculin family.Curated

Phylogenomic databases

eggNOGiENOG410IEA7 Eukaryota
ENOG4110GZM LUCA
GeneTreeiENSGT00420000029753
HOGENOMiHOG000049182
HOVERGENiHBG056980
InParanoidiQ9HC44
OMAiAATFEKH
OrthoDBiEOG091G05VV
PhylomeDBiQ9HC44
TreeFamiTF332220

Family and domain databases

InterProiView protein in InterPro
IPR028128 Vasculin_fam
PfamiView protein in Pfam
PF15337 Vasculin, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HC44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQHDFVPAW LNFSTPQSAK SPTATFEKHG EHLPRGEGRF GVSRRRHNSS
60 70 80 90 100
DGFFNNGPLR TAGDSWHQPS LFRHDSVDSG VSKGAYAGIT GNPSGWHSSS
110 120 130 140 150
RGHDGMSQRS GGGTGNHRHW NGSFHSRKGC AFQEKPPMEI REEKKEDKVE
160 170 180 190 200
KLQFEEEDFP SLNPEAGKQH QPCRPIGTPS GVWENPPSAK QPSKMLVIKK
210 220 230 240 250
VSKEDPAAAF SAAFTSPGSH HANGNKLSSV VPSVYKNLVP KPVPPPSKPN
260 270 280 290 300
AWKANRMEHK SGSLSSSRES AFTSPISVTK PVVLASGAAL SSPKESPSST
310 320 330 340 350
TPPIEISSSR LTKLTRRTTD RKSEFLKTLK DDRNGDFSEN RDCDKLEDLE
360 370 380 390 400
DNSTPEPKEN GEEGCHQNGL ALPVVEEGEV LSHSLEAEHR LLKAMGWQEY
410 420 430 440 450
PENDENCLPL TEDELKEFHM KTEQLRRNGF GKNGFLQSRS SSLFSPWRST
460 470
CKAEFEDSDT ETSSSETSDD DAWK
Length:474
Mass (Da):52,302
Last modified:March 1, 2001 - v1
Checksum:iEA0A7497C120E9C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148K → R in BAB15047 (PubMed:14702039).Curated1
Sequence conflicti306I → V in BAB15047 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039655192P → S. Corresponds to variant dbSNP:rs36067922Ensembl.1
Natural variantiVAR_039656439R → H. Corresponds to variant dbSNP:rs12093126Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024972 mRNA Translation: BAB15047.1
AF177334 mRNA Translation: AAG17978.1
AL834194 mRNA Translation: CAD38884.1
AL604028 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06959.1
CH471059 Genomic DNA Translation: EAX06960.1
BC015713 mRNA Translation: AAH15713.1
BC022218 mRNA Translation: AAH22218.1
BC052257 mRNA Translation: AAH52257.1
CCDSiCCDS528.1
RefSeqiNP_067652.1, NM_021639.4
UniGeneiHs.238432

Genome annotation databases

EnsembliENST00000290795; ENSP00000290795; ENSG00000159592
ENST00000355105; ENSP00000347224; ENSG00000159592
GeneIDi60313
KEGGihsa:60313
UCSCiuc001coq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGPBL1_HUMAN
AccessioniPrimary (citable) accession number: Q9HC44
Secondary accession number(s): D3DQ10, Q9H751
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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