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Protein

Vasculin-like protein 1

Gene

GPBP1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possible transcription factor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vasculin-like protein 1
Alternative name(s):
GC-rich promoter-binding protein 1-like 1
Gene namesi
Name:GPBP1L1
ORF Names:SP192
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28843. GPBP1L1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671715.

Polymorphism and mutation databases

BioMutaiGPBP1L1.
DMDMi74752789.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Vasculin-like protein 1PRO_0000324115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491PhosphoserineCombined sources
Modified residuei76 – 761PhosphoserineCombined sources
Modified residuei202 – 2021PhosphoserineCombined sources
Modified residuei292 – 2921PhosphoserineBy similarity
Modified residuei301 – 3011PhosphothreonineCombined sources
Modified residuei382 – 3821PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HC44.
MaxQBiQ9HC44.
PaxDbiQ9HC44.
PeptideAtlasiQ9HC44.
PRIDEiQ9HC44.

PTM databases

iPTMnetiQ9HC44.
PhosphoSiteiQ9HC44.

Expressioni

Gene expression databases

BgeeiQ9HC44.
CleanExiHS_GPBP1L1.
GenevisibleiQ9HC44. HS.

Organism-specific databases

HPAiHPA028593.

Interactioni

Protein-protein interaction databases

BioGridi121896. 43 interactions.
IntActiQ9HC44. 7 interactions.
MINTiMINT-1448714.
STRINGi9606.ENSP00000290795.

Structurei

3D structure databases

ProteinModelPortaliQ9HC44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasculin family.Curated

Phylogenomic databases

eggNOGiENOG410IEA7. Eukaryota.
ENOG4110GZM. LUCA.
GeneTreeiENSGT00420000029753.
HOGENOMiHOG000049182.
HOVERGENiHBG056980.
InParanoidiQ9HC44.
OMAiAATFEKH.
OrthoDBiEOG7QK0BP.
PhylomeDBiQ9HC44.
TreeFamiTF332220.

Family and domain databases

InterProiIPR028128. Vasculin_fam.
[Graphical view]
PfamiPF15337. Vasculin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HC44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQHDFVPAW LNFSTPQSAK SPTATFEKHG EHLPRGEGRF GVSRRRHNSS
60 70 80 90 100
DGFFNNGPLR TAGDSWHQPS LFRHDSVDSG VSKGAYAGIT GNPSGWHSSS
110 120 130 140 150
RGHDGMSQRS GGGTGNHRHW NGSFHSRKGC AFQEKPPMEI REEKKEDKVE
160 170 180 190 200
KLQFEEEDFP SLNPEAGKQH QPCRPIGTPS GVWENPPSAK QPSKMLVIKK
210 220 230 240 250
VSKEDPAAAF SAAFTSPGSH HANGNKLSSV VPSVYKNLVP KPVPPPSKPN
260 270 280 290 300
AWKANRMEHK SGSLSSSRES AFTSPISVTK PVVLASGAAL SSPKESPSST
310 320 330 340 350
TPPIEISSSR LTKLTRRTTD RKSEFLKTLK DDRNGDFSEN RDCDKLEDLE
360 370 380 390 400
DNSTPEPKEN GEEGCHQNGL ALPVVEEGEV LSHSLEAEHR LLKAMGWQEY
410 420 430 440 450
PENDENCLPL TEDELKEFHM KTEQLRRNGF GKNGFLQSRS SSLFSPWRST
460 470
CKAEFEDSDT ETSSSETSDD DAWK
Length:474
Mass (Da):52,302
Last modified:March 1, 2001 - v1
Checksum:iEA0A7497C120E9C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti148 – 1481K → R in BAB15047 (PubMed:14702039).Curated
Sequence conflicti306 – 3061I → V in BAB15047 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti192 – 1921P → S.
Corresponds to variant rs36067922 [ dbSNP | Ensembl ].
VAR_039655
Natural varianti439 – 4391R → H.
Corresponds to variant rs12093126 [ dbSNP | Ensembl ].
VAR_039656

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024972 mRNA. Translation: BAB15047.1.
AF177334 mRNA. Translation: AAG17978.1.
AL834194 mRNA. Translation: CAD38884.1.
AL604028 Genomic DNA. Translation: CAI16664.1.
CH471059 Genomic DNA. Translation: EAX06959.1.
CH471059 Genomic DNA. Translation: EAX06960.1.
BC015713 mRNA. Translation: AAH15713.1.
BC022218 mRNA. Translation: AAH22218.1.
BC052257 mRNA. Translation: AAH52257.1.
CCDSiCCDS528.1.
RefSeqiNP_067652.1. NM_021639.4.
XP_005271151.1. XM_005271094.1.
XP_005271152.1. XM_005271095.1.
UniGeneiHs.238432.

Genome annotation databases

EnsembliENST00000290795; ENSP00000290795; ENSG00000159592.
ENST00000355105; ENSP00000347224; ENSG00000159592.
GeneIDi60313.
KEGGihsa:60313.
UCSCiuc001coq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024972 mRNA. Translation: BAB15047.1.
AF177334 mRNA. Translation: AAG17978.1.
AL834194 mRNA. Translation: CAD38884.1.
AL604028 Genomic DNA. Translation: CAI16664.1.
CH471059 Genomic DNA. Translation: EAX06959.1.
CH471059 Genomic DNA. Translation: EAX06960.1.
BC015713 mRNA. Translation: AAH15713.1.
BC022218 mRNA. Translation: AAH22218.1.
BC052257 mRNA. Translation: AAH52257.1.
CCDSiCCDS528.1.
RefSeqiNP_067652.1. NM_021639.4.
XP_005271151.1. XM_005271094.1.
XP_005271152.1. XM_005271095.1.
UniGeneiHs.238432.

3D structure databases

ProteinModelPortaliQ9HC44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121896. 43 interactions.
IntActiQ9HC44. 7 interactions.
MINTiMINT-1448714.
STRINGi9606.ENSP00000290795.

PTM databases

iPTMnetiQ9HC44.
PhosphoSiteiQ9HC44.

Polymorphism and mutation databases

BioMutaiGPBP1L1.
DMDMi74752789.

Proteomic databases

EPDiQ9HC44.
MaxQBiQ9HC44.
PaxDbiQ9HC44.
PeptideAtlasiQ9HC44.
PRIDEiQ9HC44.

Protocols and materials databases

DNASUi60313.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290795; ENSP00000290795; ENSG00000159592.
ENST00000355105; ENSP00000347224; ENSG00000159592.
GeneIDi60313.
KEGGihsa:60313.
UCSCiuc001coq.4. human.

Organism-specific databases

CTDi60313.
GeneCardsiGPBP1L1.
H-InvDBHIX0000538.
HGNCiHGNC:28843. GPBP1L1.
HPAiHPA028593.
neXtProtiNX_Q9HC44.
PharmGKBiPA142671715.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEA7. Eukaryota.
ENOG4110GZM. LUCA.
GeneTreeiENSGT00420000029753.
HOGENOMiHOG000049182.
HOVERGENiHBG056980.
InParanoidiQ9HC44.
OMAiAATFEKH.
OrthoDBiEOG7QK0BP.
PhylomeDBiQ9HC44.
TreeFamiTF332220.

Miscellaneous databases

ChiTaRSiGPBP1L1. human.
GenomeRNAii60313.
PROiQ9HC44.

Gene expression databases

BgeeiQ9HC44.
CleanExiHS_GPBP1L1.
GenevisibleiQ9HC44. HS.

Family and domain databases

InterProiIPR028128. Vasculin_fam.
[Graphical view]
PfamiPF15337. Vasculin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver, Pancreas and Uterus.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 AND SER-202, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-76; THR-301 AND SER-382, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiGPBL1_HUMAN
AccessioniPrimary (citable) accession number: Q9HC44
Secondary accession number(s): D3DQ10, Q9H751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.