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Protein

Glyoxalase domain-containing protein 4

Gene

GLOD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxalase domain-containing protein 4
Gene namesi
Name:GLOD4
Synonyms:C17orf25
ORF Names:CGI-150, My027
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:14111. GLOD4.

Subcellular locationi

  • Mitochondrion 1 Publication

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi51031.
OpenTargetsiENSG00000167699.
PharmGKBiPA162389795.

Polymorphism and mutation databases

BioMutaiGLOD4.
DMDMi74718831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002803911 – 313Glyoxalase domain-containing protein 4Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146PhosphoserineBy similarity1
Modified residuei288N6-succinyllysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HC38.
MaxQBiQ9HC38.
PeptideAtlasiQ9HC38.
PRIDEiQ9HC38.
TopDownProteomicsiQ9HC38-2. [Q9HC38-2]

2D gel databases

REPRODUCTION-2DPAGEIPI00792035.

PTM databases

iPTMnetiQ9HC38.
PhosphoSitePlusiQ9HC38.
SwissPalmiQ9HC38.

Expressioni

Tissue specificityi

Expressed in heart, brain, liver, kidney, pancreas and placenta. Not expressed in skeletal muscle and lung.1 Publication

Gene expression databases

BgeeiENSG00000167699.
CleanExiHS_GLOD4.
ExpressionAtlasiQ9HC38. baseline and differential.
GenevisibleiQ9HC38. HS.

Organism-specific databases

HPAiHPA021623.
HPA023246.
HPA023248.

Interactioni

Subunit structurei

Interacts with NUDT9.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi119237. 33 interactors.
IntActiQ9HC38. 4 interactors.
MINTiMINT-6944668.

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 12Combined sources8
Helixi16 – 25Combined sources10
Beta strandi30 – 37Combined sources8
Beta strandi68 – 76Combined sources9
Turni78 – 80Combined sources3
Beta strandi83 – 89Combined sources7
Beta strandi99 – 107Combined sources9
Helixi109 – 118Combined sources10
Beta strandi123 – 126Combined sources4
Beta strandi129 – 133Combined sources5
Beta strandi139 – 145Combined sources7
Beta strandi152 – 161Combined sources10
Helixi163 – 172Combined sources10
Beta strandi177 – 182Combined sources6
Turni183 – 186Combined sources4
Beta strandi187 – 193Combined sources7
Beta strandi198 – 203Combined sources6
Beta strandi216 – 221Combined sources6
Helixi223 – 225Combined sources3
Helixi226 – 235Combined sources10
Beta strandi239 – 247Combined sources9
Beta strandi255 – 261Combined sources7
Beta strandi267 – 272Combined sources6
Helixi273 – 279Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZI1X-ray1.90A1-287[»]
ProteinModelPortaliQ9HC38.
SMRiQ9HC38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glyoxalase I family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000012340.
HOGENOMiHOG000006776.
HOVERGENiHBG056038.
InParanoidiQ9HC38.
OMAiHERAPRW.
PhylomeDBiQ9HC38.
TreeFamiTF105801.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HC38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARRALHFV FKVGNRFQTA RFYRDVLGMK VESCSVARLE CSGAISAHCS
60 70 80 90 100
DYTRITEDSF SKPYDGKWSK TMVGFGPEDD HFVAELTYNY GVGDYKLGND
110 120 130 140 150
FMGITLASSQ AVSNARKLEW PLTEVAEGVF ETEAPGGYKF YLQNRSLPQS
160 170 180 190 200
DPVLKVTLAV SDLQKSLNYW CNLLGMKIYE KDEEKQRALL GYADNQCKLE
210 220 230 240 250
LQGVKGGVDH AAAFGRIAFS CPQKELPDLE DLMKRENQKI LTPLVSLDTP
260 270 280 290 300
GKATVQVVIL ADPDGHEICF VGDEAFRELS KMDPEGSKLL DDAMAADKSD
310
EWFAKHNKPK ASG
Length:313
Mass (Da):34,793
Last modified:March 1, 2001 - v1
Checksum:i43DB04159153F07C
GO
Isoform 2 (identifier: Q9HC38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-62: ESCSVARLECSGAISAHCSDYTRITEDSFSK → LRHEEFEEGCKAACNG

Show »
Length:298
Mass (Da):33,233
Checksum:i92A5D51488DC8C02
GO
Isoform 3 (identifier: Q9HC38-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-62: ESCSVARLECSGAISAHCSDYTRITEDSFSK → LRHEEFEEGCKAACNG
     197-203: CKLELQG → VSNLGEE
     204-313: Missing.

Note: No experimental confirmation available.
Show »
Length:188
Mass (Da):21,258
Checksum:iD60B2D0ABEF774CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295A → S in AAG17987 (PubMed:11642406).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031128282M → I.1 PublicationCorresponds to variant rs17851349dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02364632 – 62ESCSV…DSFSK → LRHEEFEEGCKAACNG in isoform 2 and isoform 3. 4 PublicationsAdd BLAST31
Alternative sequenceiVSP_023647197 – 203CKLELQG → VSNLGEE in isoform 3. 1 Publication7
Alternative sequenceiVSP_023648204 – 313Missing in isoform 3. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177342 mRNA. Translation: AAG17986.1.
AF177343 mRNA. Translation: AAG17987.1.
AF061730 mRNA. Translation: AAG43141.1.
AK001488 mRNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90645.1.
CH471108 Genomic DNA. Translation: EAW90646.1.
CH471108 Genomic DNA. Translation: EAW90647.1.
CH471108 Genomic DNA. Translation: EAW90649.1.
CH471108 Genomic DNA. Translation: EAW90650.1.
BC008605 mRNA. Translation: AAH08605.1.
BC015848 mRNA. Translation: AAH15848.1.
CCDSiCCDS32520.1. [Q9HC38-2]
RefSeqiNP_057164.3. NM_016080.3. [Q9HC38-2]
UniGeneiHs.279061.
Hs.595572.

Genome annotation databases

EnsembliENST00000301328; ENSP00000301328; ENSG00000167699. [Q9HC38-1]
ENST00000301329; ENSP00000301329; ENSG00000167699. [Q9HC38-2]
GeneIDi51031.
KEGGihsa:51031.
UCSCiuc002fru.4. human. [Q9HC38-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177342 mRNA. Translation: AAG17986.1.
AF177343 mRNA. Translation: AAG17987.1.
AF061730 mRNA. Translation: AAG43141.1.
AK001488 mRNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90645.1.
CH471108 Genomic DNA. Translation: EAW90646.1.
CH471108 Genomic DNA. Translation: EAW90647.1.
CH471108 Genomic DNA. Translation: EAW90649.1.
CH471108 Genomic DNA. Translation: EAW90650.1.
BC008605 mRNA. Translation: AAH08605.1.
BC015848 mRNA. Translation: AAH15848.1.
CCDSiCCDS32520.1. [Q9HC38-2]
RefSeqiNP_057164.3. NM_016080.3. [Q9HC38-2]
UniGeneiHs.279061.
Hs.595572.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZI1X-ray1.90A1-287[»]
ProteinModelPortaliQ9HC38.
SMRiQ9HC38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119237. 33 interactors.
IntActiQ9HC38. 4 interactors.
MINTiMINT-6944668.

PTM databases

iPTMnetiQ9HC38.
PhosphoSitePlusiQ9HC38.
SwissPalmiQ9HC38.

Polymorphism and mutation databases

BioMutaiGLOD4.
DMDMi74718831.

2D gel databases

REPRODUCTION-2DPAGEIPI00792035.

Proteomic databases

EPDiQ9HC38.
MaxQBiQ9HC38.
PeptideAtlasiQ9HC38.
PRIDEiQ9HC38.
TopDownProteomicsiQ9HC38-2. [Q9HC38-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301328; ENSP00000301328; ENSG00000167699. [Q9HC38-1]
ENST00000301329; ENSP00000301329; ENSG00000167699. [Q9HC38-2]
GeneIDi51031.
KEGGihsa:51031.
UCSCiuc002fru.4. human. [Q9HC38-1]

Organism-specific databases

CTDi51031.
DisGeNETi51031.
GeneCardsiGLOD4.
HGNCiHGNC:14111. GLOD4.
HPAiHPA021623.
HPA023246.
HPA023248.
neXtProtiNX_Q9HC38.
OpenTargetsiENSG00000167699.
PharmGKBiPA162389795.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000012340.
HOGENOMiHOG000006776.
HOVERGENiHBG056038.
InParanoidiQ9HC38.
OMAiHERAPRW.
PhylomeDBiQ9HC38.
TreeFamiTF105801.

Miscellaneous databases

ChiTaRSiGLOD4. human.
GeneWikiiGLOD4.
GenomeRNAii51031.
PROiQ9HC38.

Gene expression databases

BgeeiENSG00000167699.
CleanExiHS_GLOD4.
ExpressionAtlasiQ9HC38. baseline and differential.
GenevisibleiQ9HC38. HS.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGLOD4_HUMAN
AccessioniPrimary (citable) accession number: Q9HC38
Secondary accession number(s): D3DTG9
, D3DTH1, Q96B89, Q9H3J8, Q9HC37, Q9NVN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Expression is decreased in hepatocellular carcinoma samples as compared to adjacent non-cancerous liver tissues from the same patients. Transfection in hepatocellular carcinoma cells and overexpression can inhibit the cell growth.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.