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Q9HC38

- GLOD4_HUMAN

UniProt

Q9HC38 - GLOD4_HUMAN

Protein

Glyoxalase domain-containing protein 4

Gene

GLOD4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glyoxalase domain-containing protein 4
    Gene namesi
    Name:GLOD4
    Synonyms:C17orf25
    ORF Names:CGI-150, My027
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:14111. GLOD4.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162389795.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Glyoxalase domain-containing protein 4PRO_0000280391Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei288 – 2881N6-succinyllysineBy similarity

    Proteomic databases

    MaxQBiQ9HC38.
    PaxDbiQ9HC38.
    PRIDEiQ9HC38.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00792035.

    PTM databases

    PhosphoSiteiQ9HC38.

    Expressioni

    Tissue specificityi

    Expressed in heart, brain, liver, kidney, pancreas and placenta. Not expressed in skeletal muscle and lung.1 Publication

    Gene expression databases

    ArrayExpressiQ9HC38.
    BgeeiQ9HC38.
    CleanExiHS_GLOD4.
    GenevestigatoriQ9HC38.

    Organism-specific databases

    HPAiHPA021623.
    HPA023246.
    HPA023248.

    Interactioni

    Subunit structurei

    Interacts with NUDT9.1 Publication

    Protein-protein interaction databases

    BioGridi119237. 6 interactions.
    IntActiQ9HC38. 3 interactions.
    MINTiMINT-6944668.
    STRINGi9606.ENSP00000301329.

    Structurei

    Secondary structure

    1
    313
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 128
    Helixi16 – 2510
    Beta strandi30 – 378
    Beta strandi68 – 769
    Turni78 – 803
    Beta strandi83 – 897
    Beta strandi99 – 1079
    Helixi109 – 11810
    Beta strandi123 – 1264
    Beta strandi129 – 1335
    Beta strandi139 – 1457
    Beta strandi152 – 16110
    Helixi163 – 17210
    Beta strandi177 – 1826
    Turni183 – 1864
    Beta strandi187 – 1937
    Beta strandi198 – 2036
    Beta strandi216 – 2216
    Helixi223 – 2253
    Helixi226 – 23510
    Beta strandi239 – 2479
    Beta strandi255 – 2617
    Beta strandi267 – 2726
    Helixi273 – 2797

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZI1X-ray1.90A1-287[»]
    ProteinModelPortaliQ9HC38.
    SMRiQ9HC38. Positions 1-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glyoxalase I family.Curated

    Phylogenomic databases

    eggNOGiCOG0346.
    HOGENOMiHOG000006776.
    HOVERGENiHBG056038.
    OMAiGQCELEI.
    OrthoDBiEOG769ZK8.
    PhylomeDBiQ9HC38.
    TreeFamiTF105801.

    Family and domain databases

    Gene3Di3.10.180.10. 2 hits.
    InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR025870. Glyoxalase-like_dom.
    [Graphical view]
    PfamiPF12681. Glyoxalase_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF54593. SSF54593. 2 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HC38-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAARRALHFV FKVGNRFQTA RFYRDVLGMK VESCSVARLE CSGAISAHCS    50
    DYTRITEDSF SKPYDGKWSK TMVGFGPEDD HFVAELTYNY GVGDYKLGND 100
    FMGITLASSQ AVSNARKLEW PLTEVAEGVF ETEAPGGYKF YLQNRSLPQS 150
    DPVLKVTLAV SDLQKSLNYW CNLLGMKIYE KDEEKQRALL GYADNQCKLE 200
    LQGVKGGVDH AAAFGRIAFS CPQKELPDLE DLMKRENQKI LTPLVSLDTP 250
    GKATVQVVIL ADPDGHEICF VGDEAFRELS KMDPEGSKLL DDAMAADKSD 300
    EWFAKHNKPK ASG 313
    Length:313
    Mass (Da):34,793
    Last modified:March 1, 2001 - v1
    Checksum:i43DB04159153F07C
    GO
    Isoform 2 (identifier: Q9HC38-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         32-62: ESCSVARLECSGAISAHCSDYTRITEDSFSK → LRHEEFEEGCKAACNG

    Show »
    Length:298
    Mass (Da):33,233
    Checksum:i92A5D51488DC8C02
    GO
    Isoform 3 (identifier: Q9HC38-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         32-62: ESCSVARLECSGAISAHCSDYTRITEDSFSK → LRHEEFEEGCKAACNG
         197-203: CKLELQG → VSNLGEE
         204-313: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:188
    Mass (Da):21,258
    Checksum:iD60B2D0ABEF774CE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti295 – 2951A → S in AAG17987. (PubMed:11642406)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti282 – 2821M → I.1 Publication
    Corresponds to variant rs17851349 [ dbSNP | Ensembl ].
    VAR_031128

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei32 – 6231ESCSV…DSFSK → LRHEEFEEGCKAACNG in isoform 2 and isoform 3. 4 PublicationsVSP_023646Add
    BLAST
    Alternative sequencei197 – 2037CKLELQG → VSNLGEE in isoform 3. 1 PublicationVSP_023647
    Alternative sequencei204 – 313110Missing in isoform 3. 1 PublicationVSP_023648Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177342 mRNA. Translation: AAG17986.1.
    AF177343 mRNA. Translation: AAG17987.1.
    AF061730 mRNA. Translation: AAG43141.1.
    AK001488 mRNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90645.1.
    CH471108 Genomic DNA. Translation: EAW90646.1.
    CH471108 Genomic DNA. Translation: EAW90647.1.
    CH471108 Genomic DNA. Translation: EAW90649.1.
    CH471108 Genomic DNA. Translation: EAW90650.1.
    BC008605 mRNA. Translation: AAH08605.1.
    BC015848 mRNA. Translation: AAH15848.1.
    CCDSiCCDS32520.1. [Q9HC38-2]
    RefSeqiNP_057164.3. NM_016080.3. [Q9HC38-2]
    UniGeneiHs.279061.
    Hs.595572.

    Genome annotation databases

    EnsembliENST00000301328; ENSP00000301328; ENSG00000167699. [Q9HC38-1]
    ENST00000301329; ENSP00000301329; ENSG00000167699. [Q9HC38-2]
    GeneIDi51031.
    KEGGihsa:51031.
    UCSCiuc002frt.3. human. [Q9HC38-1]
    uc002fru.3. human. [Q9HC38-2]

    Polymorphism databases

    DMDMi74718831.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177342 mRNA. Translation: AAG17986.1 .
    AF177343 mRNA. Translation: AAG17987.1 .
    AF061730 mRNA. Translation: AAG43141.1 .
    AK001488 mRNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90645.1 .
    CH471108 Genomic DNA. Translation: EAW90646.1 .
    CH471108 Genomic DNA. Translation: EAW90647.1 .
    CH471108 Genomic DNA. Translation: EAW90649.1 .
    CH471108 Genomic DNA. Translation: EAW90650.1 .
    BC008605 mRNA. Translation: AAH08605.1 .
    BC015848 mRNA. Translation: AAH15848.1 .
    CCDSi CCDS32520.1. [Q9HC38-2 ]
    RefSeqi NP_057164.3. NM_016080.3. [Q9HC38-2 ]
    UniGenei Hs.279061.
    Hs.595572.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZI1 X-ray 1.90 A 1-287 [» ]
    ProteinModelPortali Q9HC38.
    SMRi Q9HC38. Positions 1-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119237. 6 interactions.
    IntActi Q9HC38. 3 interactions.
    MINTi MINT-6944668.
    STRINGi 9606.ENSP00000301329.

    PTM databases

    PhosphoSitei Q9HC38.

    Polymorphism databases

    DMDMi 74718831.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00792035.

    Proteomic databases

    MaxQBi Q9HC38.
    PaxDbi Q9HC38.
    PRIDEi Q9HC38.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301328 ; ENSP00000301328 ; ENSG00000167699 . [Q9HC38-1 ]
    ENST00000301329 ; ENSP00000301329 ; ENSG00000167699 . [Q9HC38-2 ]
    GeneIDi 51031.
    KEGGi hsa:51031.
    UCSCi uc002frt.3. human. [Q9HC38-1 ]
    uc002fru.3. human. [Q9HC38-2 ]

    Organism-specific databases

    CTDi 51031.
    GeneCardsi GC17M000698.
    HGNCi HGNC:14111. GLOD4.
    HPAi HPA021623.
    HPA023246.
    HPA023248.
    neXtProti NX_Q9HC38.
    PharmGKBi PA162389795.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0346.
    HOGENOMi HOG000006776.
    HOVERGENi HBG056038.
    OMAi GQCELEI.
    OrthoDBi EOG769ZK8.
    PhylomeDBi Q9HC38.
    TreeFami TF105801.

    Miscellaneous databases

    ChiTaRSi GLOD4. human.
    GeneWikii GLOD4.
    GenomeRNAii 51031.
    NextBioi 53585.
    PROi Q9HC38.

    Gene expression databases

    ArrayExpressi Q9HC38.
    Bgeei Q9HC38.
    CleanExi HS_GLOD4.
    Genevestigatori Q9HC38.

    Family and domain databases

    Gene3Di 3.10.180.10. 2 hits.
    InterProi IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR025870. Glyoxalase-like_dom.
    [Graphical view ]
    Pfami PF12681. Glyoxalase_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54593. SSF54593. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocellular carcinoma."
      Qin W.X., Wan D.F., Sun F.Y., Zhang P.P., Han L.W., Huang Y., Jiang H.Q., Zhao X.T., He M., Ye Y., Cong W.M., Wu M.C., Zhang L.S., Yang N.W., Gu J.R.
      Cell Res. 11:209-216(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    2. Mao Y.M., Xie Y., Ying K.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Fetal brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-282.
      Tissue: Brain.
    6. Lubec G., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 6-12; 97-116; 156-177; 188-198; 240-252 AND 289-305, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Fetal brain cortex.
    7. "Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method."
      Zhang H.-T., Yan Z.-Q., Hu X.-B., Yang S.-L., Gong Y.
      Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35:747-751(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH NUDT9.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGLOD4_HUMAN
    AccessioniPrimary (citable) accession number: Q9HC38
    Secondary accession number(s): D3DTG9
    , D3DTH1, Q96B89, Q9H3J8, Q9HC37, Q9NVN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Expression is decreased in hepatocellular carcinoma samples as compared to adjacent non-cancerous liver tissues from the same patients. Transfection in hepatocellular carcinoma cells and overexpression can inhibit the cell growth.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3