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Q9HC38 (GLOD4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glyoxalase domain-containing protein 4
Gene names
Name:GLOD4
Synonyms:C17orf25
ORF Names:CGI-150, My027
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with NUDT9. Ref.7

Subcellular location

Mitochondrion Probable Ref.7.

Tissue specificity

Expressed in heart, brain, liver, kidney, pancreas and placenta. Not expressed in skeletal muscle and lung. Ref.1

Miscellaneous

Expression is decreased in hepatocellular carcinoma samples as compared to adjacent non-cancerous liver tissues from the same patients. Transfection in hepatocellular carcinoma cells and overexpression can inhibit the cell growth.

Sequence similarities

Belongs to the glyoxalase I family.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9HC38-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HC38-2)

The sequence of this isoform differs from the canonical sequence as follows:
     32-62: ESCSVARLECSGAISAHCSDYTRITEDSFSK → LRHEEFEEGCKAACNG
Isoform 3 (identifier: Q9HC38-3)

The sequence of this isoform differs from the canonical sequence as follows:
     32-62: ESCSVARLECSGAISAHCSDYTRITEDSFSK → LRHEEFEEGCKAACNG
     197-203: CKLELQG → VSNLGEE
     204-313: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Glyoxalase domain-containing protein 4
PRO_0000280391

Amino acid modifications

Modified residue2881N6-succinyllysine By similarity

Natural variations

Alternative sequence32 – 6231ESCSV…DSFSK → LRHEEFEEGCKAACNG in isoform 2 and isoform 3.
VSP_023646
Alternative sequence197 – 2037CKLELQG → VSNLGEE in isoform 3.
VSP_023647
Alternative sequence204 – 313110Missing in isoform 3.
VSP_023648
Natural variant2821M → I. Ref.5
Corresponds to variant rs17851349 [ dbSNP | Ensembl ].
VAR_031128

Experimental info

Sequence conflict2951A → S in AAG17987. Ref.1

Secondary structure

............................................. 313
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 43DB04159153F07C

FASTA31334,793
        10         20         30         40         50         60 
MAARRALHFV FKVGNRFQTA RFYRDVLGMK VESCSVARLE CSGAISAHCS DYTRITEDSF 

        70         80         90        100        110        120 
SKPYDGKWSK TMVGFGPEDD HFVAELTYNY GVGDYKLGND FMGITLASSQ AVSNARKLEW 

       130        140        150        160        170        180 
PLTEVAEGVF ETEAPGGYKF YLQNRSLPQS DPVLKVTLAV SDLQKSLNYW CNLLGMKIYE 

       190        200        210        220        230        240 
KDEEKQRALL GYADNQCKLE LQGVKGGVDH AAAFGRIAFS CPQKELPDLE DLMKRENQKI 

       250        260        270        280        290        300 
LTPLVSLDTP GKATVQVVIL ADPDGHEICF VGDEAFRELS KMDPEGSKLL DDAMAADKSD 

       310 
EWFAKHNKPK ASG 

« Hide

Isoform 2 [UniParc].

Checksum: 92A5D51488DC8C02
Show »

FASTA29833,233
Isoform 3 [UniParc].

Checksum: D60B2D0ABEF774CE
Show »

FASTA18821,258

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocellular carcinoma."
Qin W.X., Wan D.F., Sun F.Y., Zhang P.P., Han L.W., Huang Y., Jiang H.Q., Zhao X.T., He M., Ye Y., Cong W.M., Wu M.C., Zhang L.S., Yang N.W., Gu J.R.
Cell Res. 11:209-216(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[2]Mao Y.M., Xie Y., Ying K.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Fetal brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-282.
Tissue: Brain.
[6]Lubec G., Chen W.-Q., Sun Y.
Submitted (DEC-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 6-12; 97-116; 156-177; 188-198; 240-252 AND 289-305, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Fetal brain cortex.
[7]"Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method."
Zhang H.-T., Yan Z.-Q., Hu X.-B., Yang S.-L., Gong Y.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35:747-751(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH NUDT9.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF177342 mRNA. Translation: AAG17986.1.
AF177343 mRNA. Translation: AAG17987.1.
AF061730 mRNA. Translation: AAG43141.1.
AK001488 mRNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90645.1.
CH471108 Genomic DNA. Translation: EAW90646.1.
CH471108 Genomic DNA. Translation: EAW90647.1.
CH471108 Genomic DNA. Translation: EAW90649.1.
CH471108 Genomic DNA. Translation: EAW90650.1.
BC008605 mRNA. Translation: AAH08605.1.
BC015848 mRNA. Translation: AAH15848.1.
RefSeqNP_057164.3. NM_016080.3.
UniGeneHs.279061.
Hs.595572.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZI1X-ray1.90A1-287[»]
ProteinModelPortalQ9HC38.
SMRQ9HC38. Positions 1-293.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119237. 6 interactions.
IntActQ9HC38. 3 interactions.
MINTMINT-6944668.
STRING9606.ENSP00000301329.

PTM databases

PhosphoSiteQ9HC38.

Polymorphism databases

DMDM74718831.

2D gel databases

REPRODUCTION-2DPAGEIPI00792035.

Proteomic databases

PaxDbQ9HC38.
PRIDEQ9HC38.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301328; ENSP00000301328; ENSG00000167699. [Q9HC38-1]
ENST00000301329; ENSP00000301329; ENSG00000167699. [Q9HC38-2]
GeneID51031.
KEGGhsa:51031.
UCSCuc002frt.3. human. [Q9HC38-1]
uc002fru.3. human. [Q9HC38-2]

Organism-specific databases

CTD51031.
GeneCardsGC17M000698.
HGNCHGNC:14111. GLOD4.
HPAHPA021623.
HPA023246.
HPA023248.
neXtProtNX_Q9HC38.
PharmGKBPA162389795.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0346.
HOGENOMHOG000006776.
HOVERGENHBG056038.
OMADKAMAED.
OrthoDBEOG769ZK8.
PhylomeDBQ9HC38.
TreeFamTF105801.

Gene expression databases

ArrayExpressQ9HC38.
BgeeQ9HC38.
CleanExHS_GLOD4.
GenevestigatorQ9HC38.

Family and domain databases

InterProIPR025870. Glyoxalase-like_dom.
[Graphical view]
PfamPF12681. Glyoxalase_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGLOD4. human.
GeneWikiGLOD4.
GenomeRNAi51031.
NextBio53585.
PROQ9HC38.

Entry information

Entry nameGLOD4_HUMAN
AccessionPrimary (citable) accession number: Q9HC38
Secondary accession number(s): D3DTG9 expand/collapse secondary AC list , D3DTH1, Q96B89, Q9H3J8, Q9HC37, Q9NVN1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM