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Protein

Glyoxalase domain-containing protein 4

Gene

GLOD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxalase domain-containing protein 4
Gene namesi
Name:GLOD4
Synonyms:C17orf25
ORF Names:CGI-150, My027
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:14111. GLOD4.

Subcellular locationi

  • Mitochondrion 1 Publication

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389795.

Polymorphism and mutation databases

BioMutaiGLOD4.
DMDMi74718831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Glyoxalase domain-containing protein 4PRO_0000280391Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei288 – 2881N6-succinyllysineBy similarity

Proteomic databases

MaxQBiQ9HC38.
PaxDbiQ9HC38.
PRIDEiQ9HC38.

2D gel databases

REPRODUCTION-2DPAGEIPI00792035.

PTM databases

PhosphoSiteiQ9HC38.

Expressioni

Tissue specificityi

Expressed in heart, brain, liver, kidney, pancreas and placenta. Not expressed in skeletal muscle and lung.1 Publication

Gene expression databases

BgeeiQ9HC38.
CleanExiHS_GLOD4.
ExpressionAtlasiQ9HC38. baseline and differential.
GenevisibleiQ9HC38. HS.

Organism-specific databases

HPAiHPA021623.
HPA023246.
HPA023248.

Interactioni

Subunit structurei

Interacts with NUDT9.1 Publication

Protein-protein interaction databases

BioGridi119237. 6 interactions.
IntActiQ9HC38. 3 interactions.
MINTiMINT-6944668.
STRINGi9606.ENSP00000301329.

Structurei

Secondary structure

1
313
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 128Combined sources
Helixi16 – 2510Combined sources
Beta strandi30 – 378Combined sources
Beta strandi68 – 769Combined sources
Turni78 – 803Combined sources
Beta strandi83 – 897Combined sources
Beta strandi99 – 1079Combined sources
Helixi109 – 11810Combined sources
Beta strandi123 – 1264Combined sources
Beta strandi129 – 1335Combined sources
Beta strandi139 – 1457Combined sources
Beta strandi152 – 16110Combined sources
Helixi163 – 17210Combined sources
Beta strandi177 – 1826Combined sources
Turni183 – 1864Combined sources
Beta strandi187 – 1937Combined sources
Beta strandi198 – 2036Combined sources
Beta strandi216 – 2216Combined sources
Helixi223 – 2253Combined sources
Helixi226 – 23510Combined sources
Beta strandi239 – 2479Combined sources
Beta strandi255 – 2617Combined sources
Beta strandi267 – 2726Combined sources
Helixi273 – 2797Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZI1X-ray1.90A1-287[»]
ProteinModelPortaliQ9HC38.
SMRiQ9HC38. Positions 1-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glyoxalase I family.Curated

Phylogenomic databases

eggNOGiCOG0346.
GeneTreeiENSGT00390000012340.
HOGENOMiHOG000006776.
HOVERGENiHBG056038.
InParanoidiQ9HC38.
OMAiDETASEW.
OrthoDBiEOG769ZK8.
PhylomeDBiQ9HC38.
TreeFamiTF105801.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR025870. Glyoxalase-like_dom.
[Graphical view]
PfamiPF12681. Glyoxalase_2. 1 hit.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HC38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARRALHFV FKVGNRFQTA RFYRDVLGMK VESCSVARLE CSGAISAHCS
60 70 80 90 100
DYTRITEDSF SKPYDGKWSK TMVGFGPEDD HFVAELTYNY GVGDYKLGND
110 120 130 140 150
FMGITLASSQ AVSNARKLEW PLTEVAEGVF ETEAPGGYKF YLQNRSLPQS
160 170 180 190 200
DPVLKVTLAV SDLQKSLNYW CNLLGMKIYE KDEEKQRALL GYADNQCKLE
210 220 230 240 250
LQGVKGGVDH AAAFGRIAFS CPQKELPDLE DLMKRENQKI LTPLVSLDTP
260 270 280 290 300
GKATVQVVIL ADPDGHEICF VGDEAFRELS KMDPEGSKLL DDAMAADKSD
310
EWFAKHNKPK ASG
Length:313
Mass (Da):34,793
Last modified:March 1, 2001 - v1
Checksum:i43DB04159153F07C
GO
Isoform 2 (identifier: Q9HC38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-62: ESCSVARLECSGAISAHCSDYTRITEDSFSK → LRHEEFEEGCKAACNG

Show »
Length:298
Mass (Da):33,233
Checksum:i92A5D51488DC8C02
GO
Isoform 3 (identifier: Q9HC38-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-62: ESCSVARLECSGAISAHCSDYTRITEDSFSK → LRHEEFEEGCKAACNG
     197-203: CKLELQG → VSNLGEE
     204-313: Missing.

Note: No experimental confirmation available.
Show »
Length:188
Mass (Da):21,258
Checksum:iD60B2D0ABEF774CE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti295 – 2951A → S in AAG17987 (PubMed:11642406).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti282 – 2821M → I.1 Publication
Corresponds to variant rs17851349 [ dbSNP | Ensembl ].
VAR_031128

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei32 – 6231ESCSV…DSFSK → LRHEEFEEGCKAACNG in isoform 2 and isoform 3. 4 PublicationsVSP_023646Add
BLAST
Alternative sequencei197 – 2037CKLELQG → VSNLGEE in isoform 3. 1 PublicationVSP_023647
Alternative sequencei204 – 313110Missing in isoform 3. 1 PublicationVSP_023648Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177342 mRNA. Translation: AAG17986.1.
AF177343 mRNA. Translation: AAG17987.1.
AF061730 mRNA. Translation: AAG43141.1.
AK001488 mRNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90645.1.
CH471108 Genomic DNA. Translation: EAW90646.1.
CH471108 Genomic DNA. Translation: EAW90647.1.
CH471108 Genomic DNA. Translation: EAW90649.1.
CH471108 Genomic DNA. Translation: EAW90650.1.
BC008605 mRNA. Translation: AAH08605.1.
BC015848 mRNA. Translation: AAH15848.1.
CCDSiCCDS32520.1. [Q9HC38-2]
RefSeqiNP_057164.3. NM_016080.3. [Q9HC38-2]
UniGeneiHs.279061.
Hs.595572.

Genome annotation databases

EnsembliENST00000301328; ENSP00000301328; ENSG00000167699. [Q9HC38-1]
ENST00000301329; ENSP00000301329; ENSG00000167699. [Q9HC38-2]
GeneIDi51031.
KEGGihsa:51031.
UCSCiuc002frt.3. human. [Q9HC38-1]
uc002fru.3. human. [Q9HC38-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177342 mRNA. Translation: AAG17986.1.
AF177343 mRNA. Translation: AAG17987.1.
AF061730 mRNA. Translation: AAG43141.1.
AK001488 mRNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90645.1.
CH471108 Genomic DNA. Translation: EAW90646.1.
CH471108 Genomic DNA. Translation: EAW90647.1.
CH471108 Genomic DNA. Translation: EAW90649.1.
CH471108 Genomic DNA. Translation: EAW90650.1.
BC008605 mRNA. Translation: AAH08605.1.
BC015848 mRNA. Translation: AAH15848.1.
CCDSiCCDS32520.1. [Q9HC38-2]
RefSeqiNP_057164.3. NM_016080.3. [Q9HC38-2]
UniGeneiHs.279061.
Hs.595572.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZI1X-ray1.90A1-287[»]
ProteinModelPortaliQ9HC38.
SMRiQ9HC38. Positions 1-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119237. 6 interactions.
IntActiQ9HC38. 3 interactions.
MINTiMINT-6944668.
STRINGi9606.ENSP00000301329.

PTM databases

PhosphoSiteiQ9HC38.

Polymorphism and mutation databases

BioMutaiGLOD4.
DMDMi74718831.

2D gel databases

REPRODUCTION-2DPAGEIPI00792035.

Proteomic databases

MaxQBiQ9HC38.
PaxDbiQ9HC38.
PRIDEiQ9HC38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301328; ENSP00000301328; ENSG00000167699. [Q9HC38-1]
ENST00000301329; ENSP00000301329; ENSG00000167699. [Q9HC38-2]
GeneIDi51031.
KEGGihsa:51031.
UCSCiuc002frt.3. human. [Q9HC38-1]
uc002fru.3. human. [Q9HC38-2]

Organism-specific databases

CTDi51031.
GeneCardsiGC17M000710.
HGNCiHGNC:14111. GLOD4.
HPAiHPA021623.
HPA023246.
HPA023248.
neXtProtiNX_Q9HC38.
PharmGKBiPA162389795.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0346.
GeneTreeiENSGT00390000012340.
HOGENOMiHOG000006776.
HOVERGENiHBG056038.
InParanoidiQ9HC38.
OMAiDETASEW.
OrthoDBiEOG769ZK8.
PhylomeDBiQ9HC38.
TreeFamiTF105801.

Miscellaneous databases

ChiTaRSiGLOD4. human.
GeneWikiiGLOD4.
GenomeRNAii51031.
NextBioi53585.
PROiQ9HC38.

Gene expression databases

BgeeiQ9HC38.
CleanExiHS_GLOD4.
ExpressionAtlasiQ9HC38. baseline and differential.
GenevisibleiQ9HC38. HS.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR025870. Glyoxalase-like_dom.
[Graphical view]
PfamiPF12681. Glyoxalase_2. 1 hit.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocellular carcinoma."
    Qin W.X., Wan D.F., Sun F.Y., Zhang P.P., Han L.W., Huang Y., Jiang H.Q., Zhao X.T., He M., Ye Y., Cong W.M., Wu M.C., Zhang L.S., Yang N.W., Gu J.R.
    Cell Res. 11:209-216(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  2. Mao Y.M., Xie Y., Ying K.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-282.
    Tissue: Brain.
  6. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 6-12; 97-116; 156-177; 188-198; 240-252 AND 289-305, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  7. "Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method."
    Zhang H.-T., Yan Z.-Q., Hu X.-B., Yang S.-L., Gong Y.
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35:747-751(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH NUDT9.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGLOD4_HUMAN
AccessioniPrimary (citable) accession number: Q9HC38
Secondary accession number(s): D3DTG9
, D3DTH1, Q96B89, Q9H3J8, Q9HC37, Q9NVN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Expression is decreased in hepatocellular carcinoma samples as compared to adjacent non-cancerous liver tissues from the same patients. Transfection in hepatocellular carcinoma cells and overexpression can inhibit the cell growth.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.