Q9HC36 (RMTL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA methyltransferase-like protein 1
EC=2.1.1.-

Gene names

Name:	RNMTL1
ORF Names:	HC90

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable RNA methyltransferase By similarity.
Tissue specificity	Expressed at same level in normal liver and hepatocarcinoma. Ref.6
Sequence similarities	Belongs to the RNA methyltransferase TrmH family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA processing Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Ensembl
Molecular_function	RNA methyltransferase activity Inferred from electronic annotation. Source: InterPro poly(A) RNA binding Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CUL2	Q13617	1	EBI-1045440,EBI-456179
NTHL1	P78549	1	EBI-1045440,EBI-1049350
NUDT1	P36639	1	EBI-1045440,EBI-1048967
PUF60	Q9UHX1	1	EBI-1045440,EBI-1053259
SMNDC1	O75940	1	EBI-1045440,EBI-1052641
TRIP6	Q15654	1	EBI-1045440,EBI-742327

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	RNA methyltransferase-like protein 1		PRO_0000311301
Sites
	Binding site	356	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	380	1	S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	389	1	S-adenosyl-L-methionine; via amide nitrogen By similarity
Natural variations
	Natural variant	8	1	A → S. Ref.5 Corresponds to variant rs2273454 [ dbSNP | Ensembl ].		VAR_037217
	Natural variant	45	1	G → E. Corresponds to variant rs2249542 [ dbSNP | Ensembl ].		VAR_037218
	Natural variant	185	1	I → V. Ref.5 Corresponds to variant rs17854653 [ dbSNP | Ensembl ].		VAR_037219
	Natural variant	326	1	E → Q. Corresponds to variant rs35780267 [ dbSNP | Ensembl ].		VAR_037220
Experimental info
	Sequence conflict	247	1	A → V in BAD96620. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9HC36 [UniParc]. Last modified June 1, 2002. Version 2. Checksum: CC06C27489A89FC3	FASTA	420	47,020
	10 20 30 40 50 60 MAALVRPARF VVRPLLQVVQ AWDLDARRWV RALRRSPVKV VFPSGEVVEQ KRAPGKQPRK 70 80 90 100 110 120 APSEASAQEQ REKQPLEESA SRAPSTWEES GLRYDKAYPG DRRLSSVMTI VKSRPFREKQ 130 140 150 160 170 180 GKILLEGRRL ISDALKAGAV PKMFFFSRLE YLKELPVDKL KGVSLIKVKF EDIKDWSDLV 190 200 210 220 230 240 TPQGIMGIFA KPDHVKMTYP KTQLQHSLPL LLICDNLRDP GNLGTILRSA AGAGCSKVLL 250 260 270 280 290 300 TKGCVDAWEP KVLRAGMGAH FRMPIINNLE WETVPNYLPP DTRVYVADNC GLYAQAEMSN 310 320 330 340 350 360 KASDHGWVCD QRVMKFHKYE EEEDVETGAS QDWLPHVEVQ SYDSDWTEAP AAVVIGGETY 370 380 390 400 410 420 GVSLESLQLA ESTGGKRLLI PVVPGVDSLN SAMAASILLF EGKRQLRGRA EDLSRDRSYH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Teratocarcinoma.
[2]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[3]	"Homo sapiens P579 chromosome 17p DNA sequence fragment." Gu J.R., Zhao X.T., Wan D.F., Jiang H.Q., Huang Y., He Y.H., Qin W.X., Han L.W., Zhang P.P., Qiu X.K., He L.P. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-8 AND VAL-185. Tissue: Brain and Skin.
[6]	"The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene." Xu J., De Zhu J., Ni M., Wan F., Gu J.R. Cell Res. 12:177-197(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001443 mRNA. Translation: BAA91694.1. AK222900 mRNA. Translation: BAD96620.1. AF177344 mRNA. Translation: AAG17988.2. CH471108 Genomic DNA. Translation: EAW90642.1. BC011550 mRNA. Translation: AAH11550.1. BC050614 mRNA. Translation: AAH50614.1.
CCDS	CCDS10997.1.
RefSeq	NP_060616.1. NM_018146.2.
UniGene	Hs.182729.
3D structure databases
ProteinModelPortal	Q9HC36.
SMR	Q9HC36. Positions 103-405.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	120477. 19 interactions.
IntAct	Q9HC36. 2 interactions.
MINT	MINT-8052394.
STRING	9606.ENSP00000306080.
PTM databases
PhosphoSite	Q9HC36.
Polymorphism databases
DMDM	74734265.
Proteomic databases
MaxQB	Q9HC36.
PaxDb	Q9HC36.
PRIDE	Q9HC36.
Protocols and materials databases
DNASU	55178.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304478; ENSP00000306080; ENSG00000171861.
GeneID	55178.
KEGG	hsa:55178.
UCSC	uc002frw.3. human.
Organism-specific databases
CTD	55178.
GeneCards	GC17P000685.
HGNC	HGNC:18485. RNMTL1.
HPA	HPA022534. HPA023031. HPA023292.
MIM	612600. gene.
neXtProt	NX_Q9HC36.
PharmGKB	PA38341.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0566.
HOGENOM	HOG000154151.
HOVERGEN	HBG108411.
InParanoid	Q9HC36.
OMA	RYDKAFP.
OrthoDB	EOG7MSMPJ.
PhylomeDB	Q9HC36.
TreeFam	TF323420.
Gene expression databases
ArrayExpress	Q9HC36.
Bgee	Q9HC36.
CleanEx	HS_RNMTL1.
Genevestigator	Q9HC36.
Family and domain databases
Gene3D	3.30.1330.30. 1 hit. 3.40.1280.10. 2 hits.
InterPro	IPR029028. Alpha/beta_knot_MTases. IPR029064. L30e-like. IPR001537. SpoU_MeTrfase. IPR013123. SpoU_subst-bd. IPR029026. tRNA_m1G_MTases_N. [Graphical view]
Pfam	PF00588. SpoU_methylase. 1 hit. PF08032. SpoU_sub_bind. 1 hit. [Graphical view]
SMART	SM00967. SpoU_sub_bind. 1 hit. [Graphical view]
SUPFAM	SSF55315. SSF55315. 1 hit. SSF75217. SSF75217. 2 hits.
ProtoNet	Search...
Other
ChiTaRS	RNMTL1. human.
GeneWiki	RNMTL1.
GenomeRNAi	55178.
NextBio	58983.
PRO	Q9HC36.
SOURCE	Search...

Entry information

Entry name

RMTL1_HUMAN

Accession

Primary (citable) accession number: Q9HC36
Secondary accession number(s): Q53GN1 , Q86VC3, Q96F76, Q9NVQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	June 1, 2002
Last modified:	July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.