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Q9HC36

- RMTL1_HUMAN

UniProt

Q9HC36 - RMTL1_HUMAN

Protein

RNA methyltransferase-like protein 1

Gene

RNMTL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Probable RNA methyltransferase.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei356 – 3561S-adenosyl-L-methionine; via carbonyl oxygenBy similarity
    Binding sitei380 – 3801S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei389 – 3891S-adenosyl-L-methionine; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. RNA methyltransferase activity Source: InterPro

    GO - Biological processi

    1. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA methyltransferase-like protein 1 (EC:2.1.1.-)
    Gene namesi
    Name:RNMTL1
    ORF Names:HC90
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:18485. RNMTL1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38341.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420RNA methyltransferase-like protein 1PRO_0000311301Add
    BLAST

    Proteomic databases

    MaxQBiQ9HC36.
    PaxDbiQ9HC36.
    PRIDEiQ9HC36.

    PTM databases

    PhosphoSiteiQ9HC36.

    Expressioni

    Tissue specificityi

    Expressed at same level in normal liver and hepatocarcinoma.1 Publication

    Gene expression databases

    ArrayExpressiQ9HC36.
    BgeeiQ9HC36.
    CleanExiHS_RNMTL1.
    GenevestigatoriQ9HC36.

    Organism-specific databases

    HPAiHPA022534.
    HPA023031.
    HPA023292.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CUL2Q136171EBI-1045440,EBI-456179
    NTHL1P785491EBI-1045440,EBI-1049350
    NUDT1P366391EBI-1045440,EBI-1048967
    PUF60Q9UHX11EBI-1045440,EBI-1053259
    SMNDC1O759401EBI-1045440,EBI-1052641
    TRIP6Q156541EBI-1045440,EBI-742327

    Protein-protein interaction databases

    BioGridi120477. 20 interactions.
    IntActiQ9HC36. 2 interactions.
    MINTiMINT-8052394.
    STRINGi9606.ENSP00000306080.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HC36.
    SMRiQ9HC36. Positions 103-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNA methyltransferase TrmH family.Curated

    Phylogenomic databases

    eggNOGiCOG0566.
    HOGENOMiHOG000154151.
    HOVERGENiHBG108411.
    InParanoidiQ9HC36.
    OMAiRYDKAFP.
    OrthoDBiEOG7MSMPJ.
    PhylomeDBiQ9HC36.
    TreeFamiTF323420.

    Family and domain databases

    Gene3Di3.30.1330.30. 1 hit.
    3.40.1280.10. 2 hits.
    InterProiIPR029028. Alpha/beta_knot_MTases.
    IPR029064. L30e-like.
    IPR001537. SpoU_MeTrfase.
    IPR013123. SpoU_subst-bd.
    IPR029026. tRNA_m1G_MTases_N.
    [Graphical view]
    PfamiPF00588. SpoU_methylase. 1 hit.
    PF08032. SpoU_sub_bind. 1 hit.
    [Graphical view]
    SMARTiSM00967. SpoU_sub_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF55315. SSF55315. 1 hit.
    SSF75217. SSF75217. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9HC36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALVRPARF VVRPLLQVVQ AWDLDARRWV RALRRSPVKV VFPSGEVVEQ    50
    KRAPGKQPRK APSEASAQEQ REKQPLEESA SRAPSTWEES GLRYDKAYPG 100
    DRRLSSVMTI VKSRPFREKQ GKILLEGRRL ISDALKAGAV PKMFFFSRLE 150
    YLKELPVDKL KGVSLIKVKF EDIKDWSDLV TPQGIMGIFA KPDHVKMTYP 200
    KTQLQHSLPL LLICDNLRDP GNLGTILRSA AGAGCSKVLL TKGCVDAWEP 250
    KVLRAGMGAH FRMPIINNLE WETVPNYLPP DTRVYVADNC GLYAQAEMSN 300
    KASDHGWVCD QRVMKFHKYE EEEDVETGAS QDWLPHVEVQ SYDSDWTEAP 350
    AAVVIGGETY GVSLESLQLA ESTGGKRLLI PVVPGVDSLN SAMAASILLF 400
    EGKRQLRGRA EDLSRDRSYH 420
    Length:420
    Mass (Da):47,020
    Last modified:June 1, 2002 - v2
    Checksum:iCC06C27489A89FC3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti247 – 2471A → V in BAD96620. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81A → S.1 Publication
    Corresponds to variant rs2273454 [ dbSNP | Ensembl ].
    VAR_037217
    Natural varianti45 – 451G → E.
    Corresponds to variant rs2249542 [ dbSNP | Ensembl ].
    VAR_037218
    Natural varianti185 – 1851I → V.1 Publication
    Corresponds to variant rs17854653 [ dbSNP | Ensembl ].
    VAR_037219
    Natural varianti326 – 3261E → Q.
    Corresponds to variant rs35780267 [ dbSNP | Ensembl ].
    VAR_037220

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001443 mRNA. Translation: BAA91694.1.
    AK222900 mRNA. Translation: BAD96620.1.
    AF177344 mRNA. Translation: AAG17988.2.
    CH471108 Genomic DNA. Translation: EAW90642.1.
    BC011550 mRNA. Translation: AAH11550.1.
    BC050614 mRNA. Translation: AAH50614.1.
    CCDSiCCDS10997.1.
    RefSeqiNP_060616.1. NM_018146.2.
    UniGeneiHs.182729.

    Genome annotation databases

    EnsembliENST00000304478; ENSP00000306080; ENSG00000171861.
    GeneIDi55178.
    KEGGihsa:55178.
    UCSCiuc002frw.3. human.

    Polymorphism databases

    DMDMi74734265.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001443 mRNA. Translation: BAA91694.1 .
    AK222900 mRNA. Translation: BAD96620.1 .
    AF177344 mRNA. Translation: AAG17988.2 .
    CH471108 Genomic DNA. Translation: EAW90642.1 .
    BC011550 mRNA. Translation: AAH11550.1 .
    BC050614 mRNA. Translation: AAH50614.1 .
    CCDSi CCDS10997.1.
    RefSeqi NP_060616.1. NM_018146.2.
    UniGenei Hs.182729.

    3D structure databases

    ProteinModelPortali Q9HC36.
    SMRi Q9HC36. Positions 103-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120477. 20 interactions.
    IntActi Q9HC36. 2 interactions.
    MINTi MINT-8052394.
    STRINGi 9606.ENSP00000306080.

    PTM databases

    PhosphoSitei Q9HC36.

    Polymorphism databases

    DMDMi 74734265.

    Proteomic databases

    MaxQBi Q9HC36.
    PaxDbi Q9HC36.
    PRIDEi Q9HC36.

    Protocols and materials databases

    DNASUi 55178.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304478 ; ENSP00000306080 ; ENSG00000171861 .
    GeneIDi 55178.
    KEGGi hsa:55178.
    UCSCi uc002frw.3. human.

    Organism-specific databases

    CTDi 55178.
    GeneCardsi GC17P000685.
    HGNCi HGNC:18485. RNMTL1.
    HPAi HPA022534.
    HPA023031.
    HPA023292.
    MIMi 612600. gene.
    neXtProti NX_Q9HC36.
    PharmGKBi PA38341.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0566.
    HOGENOMi HOG000154151.
    HOVERGENi HBG108411.
    InParanoidi Q9HC36.
    OMAi RYDKAFP.
    OrthoDBi EOG7MSMPJ.
    PhylomeDBi Q9HC36.
    TreeFami TF323420.

    Miscellaneous databases

    ChiTaRSi RNMTL1. human.
    GeneWikii RNMTL1.
    GenomeRNAii 55178.
    NextBioi 58983.
    PROi Q9HC36.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HC36.
    Bgeei Q9HC36.
    CleanExi HS_RNMTL1.
    Genevestigatori Q9HC36.

    Family and domain databases

    Gene3Di 3.30.1330.30. 1 hit.
    3.40.1280.10. 2 hits.
    InterProi IPR029028. Alpha/beta_knot_MTases.
    IPR029064. L30e-like.
    IPR001537. SpoU_MeTrfase.
    IPR013123. SpoU_subst-bd.
    IPR029026. tRNA_m1G_MTases_N.
    [Graphical view ]
    Pfami PF00588. SpoU_methylase. 1 hit.
    PF08032. SpoU_sub_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00967. SpoU_sub_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55315. SSF55315. 1 hit.
    SSF75217. SSF75217. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. "Homo sapiens P579 chromosome 17p DNA sequence fragment."
      Gu J.R., Zhao X.T., Wan D.F., Jiang H.Q., Huang Y., He Y.H., Qin W.X., Han L.W., Zhang P.P., Qiu X.K., He L.P.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-8 AND VAL-185.
      Tissue: Brain and Skin.
    6. "The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene."
      Xu J., De Zhu J., Ni M., Wan F., Gu J.R.
      Cell Res. 12:177-197(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRMTL1_HUMAN
    AccessioniPrimary (citable) accession number: Q9HC36
    Secondary accession number(s): Q53GN1
    , Q86VC3, Q96F76, Q9NVQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3