UniProtKB - Q9HC36 (MRM3_HUMAN)
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Protein
rRNA methyltransferase 3, mitochondrial
Gene
MRM3
Organism
Homo sapiens (Human)
Status
Functioni
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.3 Publications
Catalytic activityi
S-adenosyl-L-methionine + guanosine(1370) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine(1370) in 16S rRNA.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 356 | S-adenosyl-L-methionine; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 380 | S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenBy similarity | 1 | |
Binding sitei | 389 | S-adenosyl-L-methionine; via amide nitrogenBy similarity | 1 |
GO - Molecular functioni
- RNA binding Source: UniProtKB
- rRNA (guanosine-2'-O-)-methyltransferase activity Source: Reactome
GO - Biological processi
- rRNA 2'-O-methylation Source: Reactome
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | rRNA processing |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
Reactomei | R-HSA-6793080. rRNA modification in the mitochondrion. |
Names & Taxonomyi
Protein namesi | Recommended name: rRNA methyltransferase 3, mitochondrial1 Publication (EC:2.1.1.-2 Publications)Alternative name(s): 16S rRNA (guanosine(1370)-2'-O)-methyltransferase1 Publication 16S rRNA [Gm1370] 2'-O-methyltransferase1 Publication RNA methyltransferase-like protein 11 Publication |
Gene namesi | ORF Names:HC90 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171861.10. |
HGNCi | HGNC:18485. MRM3. |
MIMi | 612600. gene. |
neXtProti | NX_Q9HC36. |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000171861. |
PharmGKBi | PA38341. |
Polymorphism and mutation databases
BioMutai | RNMTL1. |
DMDMi | 74734265. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 40 | MitochondrionSequence analysisAdd BLAST | 40 | |
ChainiPRO_0000311301 | 41 – 420 | rRNA methyltransferase 3, mitochondrialAdd BLAST | 380 |
Proteomic databases
EPDi | Q9HC36. |
MaxQBi | Q9HC36. |
PaxDbi | Q9HC36. |
PeptideAtlasi | Q9HC36. |
PRIDEi | Q9HC36. |
PTM databases
iPTMneti | Q9HC36. |
PhosphoSitePlusi | Q9HC36. |
Expressioni
Tissue specificityi
Expressed at same level in normal liver and hepatocarcinoma.1 Publication
Gene expression databases
Bgeei | ENSG00000171861. |
CleanExi | HS_RNMTL1. |
ExpressionAtlasi | Q9HC36. baseline and differential. |
Genevisiblei | Q9HC36. HS. |
Organism-specific databases
HPAi | HPA022534. HPA023031. HPA023292. |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
FHL3 | Q13643 | 5 | EBI-1045440,EBI-741101 |
Protein-protein interaction databases
BioGridi | 120477. 58 interactors. |
IntActi | Q9HC36. 20 interactors. |
MINTi | Q9HC36. |
STRINGi | 9606.ENSP00000306080. |
Family & Domainsi
Sequence similaritiesi
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2506. Eukaryota. COG0566. LUCA. |
GeneTreei | ENSGT00390000017317. |
HOGENOMi | HOG000154151. |
HOVERGENi | HBG108411. |
InParanoidi | Q9HC36. |
KOi | K20095. |
OMAi | INNLDWE. |
OrthoDBi | EOG091G0OPI. |
PhylomeDBi | Q9HC36. |
TreeFami | TF323420. |
Family and domain databases
Gene3Di | 3.30.1330.30. 1 hit. |
InterProi | View protein in InterPro IPR029028. Alpha/beta_knot_MTases. IPR029064. L30e-like. IPR001537. SpoU_MeTrfase. IPR013123. SpoU_subst-bd. |
Pfami | View protein in Pfam PF00588. SpoU_methylase. 1 hit. |
SMARTi | View protein in SMART SM00967. SpoU_sub_bind. 1 hit. |
SUPFAMi | SSF55315. SSF55315. 1 hit. SSF75217. SSF75217. 2 hits. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9HC36-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAALVRPARF VVRPLLQVVQ AWDLDARRWV RALRRSPVKV VFPSGEVVEQ
60 70 80 90 100
KRAPGKQPRK APSEASAQEQ REKQPLEESA SRAPSTWEES GLRYDKAYPG
110 120 130 140 150
DRRLSSVMTI VKSRPFREKQ GKILLEGRRL ISDALKAGAV PKMFFFSRLE
160 170 180 190 200
YLKELPVDKL KGVSLIKVKF EDIKDWSDLV TPQGIMGIFA KPDHVKMTYP
210 220 230 240 250
KTQLQHSLPL LLICDNLRDP GNLGTILRSA AGAGCSKVLL TKGCVDAWEP
260 270 280 290 300
KVLRAGMGAH FRMPIINNLE WETVPNYLPP DTRVYVADNC GLYAQAEMSN
310 320 330 340 350
KASDHGWVCD QRVMKFHKYE EEEDVETGAS QDWLPHVEVQ SYDSDWTEAP
360 370 380 390 400
AAVVIGGETY GVSLESLQLA ESTGGKRLLI PVVPGVDSLN SAMAASILLF
410 420
EGKRQLRGRA EDLSRDRSYH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 247 | A → V in BAD96620 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037217 | 8 | A → S1 PublicationCorresponds to variant dbSNP:rs2273454Ensembl. | 1 | |
Natural variantiVAR_037218 | 45 | G → E. Corresponds to variant dbSNP:rs2249542Ensembl. | 1 | |
Natural variantiVAR_037219 | 185 | I → V1 PublicationCorresponds to variant dbSNP:rs17854653Ensembl. | 1 | |
Natural variantiVAR_037220 | 326 | E → Q. Corresponds to variant dbSNP:rs35780267Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001443 mRNA. Translation: BAA91694.1. AK222900 mRNA. Translation: BAD96620.1. AF177344 mRNA. Translation: AAG17988.2. CH471108 Genomic DNA. Translation: EAW90642.1. BC011550 mRNA. Translation: AAH11550.1. BC050614 mRNA. Translation: AAH50614.1. |
CCDSi | CCDS10997.1. |
RefSeqi | NP_001304876.1. NM_001317947.1. NP_060616.1. NM_018146.3. |
UniGenei | Hs.182729. |
Genome annotation databases
Ensembli | ENST00000304478; ENSP00000306080; ENSG00000171861. |
GeneIDi | 55178. |
KEGGi | hsa:55178. |
UCSCi | uc002frw.4. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | MRM3_HUMAN | |
Accessioni | Q9HC36Primary (citable) accession number: Q9HC36 Secondary accession number(s): Q53GN1 Q9NVQ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | June 1, 2002 | |
Last modified: | March 28, 2018 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |