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Protein

rRNA methyltransferase 3, mitochondrial

Gene

MRM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.3 Publications

Catalytic activityi

S-adenosyl-L-methionine + guanosine(1370) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine(1370) in 16S rRNA.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei356S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei380S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei389S-adenosyl-L-methionine; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171861-MONOMER.
ReactomeiR-HSA-6793080. rRNA modification in the mitochondrion.

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA methyltransferase 3, mitochondrial1 Publication (EC:2.1.1.-2 Publications)
Alternative name(s):
16S rRNA (guanosine(1370)-2'-O)-methyltransferase1 Publication
16S rRNA [Gm1370] 2'-O-methyltransferase1 Publication
RNA methyltransferase-like protein 11 Publication
Gene namesi
Name:MRM31 PublicationImported
Synonyms:RNMTL11 Publication
ORF Names:HC90
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18485. MRM3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171861.
PharmGKBiPA38341.

Polymorphism and mutation databases

BioMutaiRNMTL1.
DMDMi74734265.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 40MitochondrionSequence analysisAdd BLAST40
ChainiPRO_000031130141 – 420rRNA methyltransferase 3, mitochondrialAdd BLAST380

Proteomic databases

EPDiQ9HC36.
MaxQBiQ9HC36.
PaxDbiQ9HC36.
PeptideAtlasiQ9HC36.
PRIDEiQ9HC36.

PTM databases

iPTMnetiQ9HC36.
PhosphoSitePlusiQ9HC36.

Expressioni

Tissue specificityi

Expressed at same level in normal liver and hepatocarcinoma.1 Publication

Gene expression databases

BgeeiENSG00000171861.
CleanExiHS_RNMTL1.
ExpressionAtlasiQ9HC36. baseline and differential.
GenevisibleiQ9HC36. HS.

Organism-specific databases

HPAiHPA022534.
HPA023031.
HPA023292.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136435EBI-1045440,EBI-741101

Protein-protein interaction databases

BioGridi120477. 51 interactors.
IntActiQ9HC36. 7 interactors.
MINTiMINT-8052394.
STRINGi9606.ENSP00000306080.

Structurei

3D structure databases

ProteinModelPortaliQ9HC36.
SMRiQ9HC36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2506. Eukaryota.
COG0566. LUCA.
GeneTreeiENSGT00390000017317.
HOGENOMiHOG000154151.
HOVERGENiHBG108411.
InParanoidiQ9HC36.
KOiK20095.
OMAiRYDKAFP.
OrthoDBiEOG091G0OPI.
PhylomeDBiQ9HC36.
TreeFamiTF323420.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
3.40.1280.10. 2 hits.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR029064. L30e-like.
IPR001537. SpoU_MeTrfase.
IPR013123. SpoU_subst-bd.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamiPF00588. SpoU_methylase. 1 hit.
[Graphical view]
SMARTiSM00967. SpoU_sub_bind. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
SSF75217. SSF75217. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HC36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALVRPARF VVRPLLQVVQ AWDLDARRWV RALRRSPVKV VFPSGEVVEQ
60 70 80 90 100
KRAPGKQPRK APSEASAQEQ REKQPLEESA SRAPSTWEES GLRYDKAYPG
110 120 130 140 150
DRRLSSVMTI VKSRPFREKQ GKILLEGRRL ISDALKAGAV PKMFFFSRLE
160 170 180 190 200
YLKELPVDKL KGVSLIKVKF EDIKDWSDLV TPQGIMGIFA KPDHVKMTYP
210 220 230 240 250
KTQLQHSLPL LLICDNLRDP GNLGTILRSA AGAGCSKVLL TKGCVDAWEP
260 270 280 290 300
KVLRAGMGAH FRMPIINNLE WETVPNYLPP DTRVYVADNC GLYAQAEMSN
310 320 330 340 350
KASDHGWVCD QRVMKFHKYE EEEDVETGAS QDWLPHVEVQ SYDSDWTEAP
360 370 380 390 400
AAVVIGGETY GVSLESLQLA ESTGGKRLLI PVVPGVDSLN SAMAASILLF
410 420
EGKRQLRGRA EDLSRDRSYH
Length:420
Mass (Da):47,020
Last modified:June 1, 2002 - v2
Checksum:iCC06C27489A89FC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247A → V in BAD96620 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0372178A → S.1 PublicationCorresponds to variant rs2273454dbSNPEnsembl.1
Natural variantiVAR_03721845G → E.Corresponds to variant rs2249542dbSNPEnsembl.1
Natural variantiVAR_037219185I → V.1 PublicationCorresponds to variant rs17854653dbSNPEnsembl.1
Natural variantiVAR_037220326E → Q.Corresponds to variant rs35780267dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001443 mRNA. Translation: BAA91694.1.
AK222900 mRNA. Translation: BAD96620.1.
AF177344 mRNA. Translation: AAG17988.2.
CH471108 Genomic DNA. Translation: EAW90642.1.
BC011550 mRNA. Translation: AAH11550.1.
BC050614 mRNA. Translation: AAH50614.1.
CCDSiCCDS10997.1.
RefSeqiNP_001304876.1. NM_001317947.1.
NP_060616.1. NM_018146.3.
UniGeneiHs.182729.

Genome annotation databases

EnsembliENST00000304478; ENSP00000306080; ENSG00000171861.
GeneIDi55178.
KEGGihsa:55178.
UCSCiuc002frw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001443 mRNA. Translation: BAA91694.1.
AK222900 mRNA. Translation: BAD96620.1.
AF177344 mRNA. Translation: AAG17988.2.
CH471108 Genomic DNA. Translation: EAW90642.1.
BC011550 mRNA. Translation: AAH11550.1.
BC050614 mRNA. Translation: AAH50614.1.
CCDSiCCDS10997.1.
RefSeqiNP_001304876.1. NM_001317947.1.
NP_060616.1. NM_018146.3.
UniGeneiHs.182729.

3D structure databases

ProteinModelPortaliQ9HC36.
SMRiQ9HC36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120477. 51 interactors.
IntActiQ9HC36. 7 interactors.
MINTiMINT-8052394.
STRINGi9606.ENSP00000306080.

PTM databases

iPTMnetiQ9HC36.
PhosphoSitePlusiQ9HC36.

Polymorphism and mutation databases

BioMutaiRNMTL1.
DMDMi74734265.

Proteomic databases

EPDiQ9HC36.
MaxQBiQ9HC36.
PaxDbiQ9HC36.
PeptideAtlasiQ9HC36.
PRIDEiQ9HC36.

Protocols and materials databases

DNASUi55178.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304478; ENSP00000306080; ENSG00000171861.
GeneIDi55178.
KEGGihsa:55178.
UCSCiuc002frw.4. human.

Organism-specific databases

CTDi55178.
GeneCardsiRNMTL1.
HGNCiHGNC:18485. MRM3.
HPAiHPA022534.
HPA023031.
HPA023292.
MIMi612600. gene.
neXtProtiNX_Q9HC36.
OpenTargetsiENSG00000171861.
PharmGKBiPA38341.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2506. Eukaryota.
COG0566. LUCA.
GeneTreeiENSGT00390000017317.
HOGENOMiHOG000154151.
HOVERGENiHBG108411.
InParanoidiQ9HC36.
KOiK20095.
OMAiRYDKAFP.
OrthoDBiEOG091G0OPI.
PhylomeDBiQ9HC36.
TreeFamiTF323420.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171861-MONOMER.
ReactomeiR-HSA-6793080. rRNA modification in the mitochondrion.

Miscellaneous databases

ChiTaRSiRNMTL1. human.
GeneWikiiRNMTL1.
GenomeRNAii55178.
PROiQ9HC36.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171861.
CleanExiHS_RNMTL1.
ExpressionAtlasiQ9HC36. baseline and differential.
GenevisibleiQ9HC36. HS.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
3.40.1280.10. 2 hits.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR029064. L30e-like.
IPR001537. SpoU_MeTrfase.
IPR013123. SpoU_subst-bd.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamiPF00588. SpoU_methylase. 1 hit.
[Graphical view]
SMARTiSM00967. SpoU_sub_bind. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
SSF75217. SSF75217. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMRM3_HUMAN
AccessioniPrimary (citable) accession number: Q9HC36
Secondary accession number(s): Q53GN1
, Q86VC3, Q96F76, Q9NVQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.