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Q9HC24

- LFG4_HUMAN

UniProt

Q9HC24 - LFG4_HUMAN

Protein

Protein lifeguard 4

Gene

TMBIM4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. negative regulation of apoptotic process Source: UniProtKB
    3. regulation of calcium-mediated signaling Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    TCDBi1.A.14.3.6. the testis-enhanced gene transfer (tegt) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein lifeguard 4
    Alternative name(s):
    Golgi anti-apoptotic protein
    Protein S1R
    Transmembrane BAX inhibitor motif-containing protein 4
    Z-protein
    Gene namesi
    Name:TMBIM4
    Synonyms:GAAP, LFG4
    ORF Names:CGI-119
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24257. TMBIM4.

    Subcellular locationi

    Golgi apparatus membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. Golgi stack Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670805.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238Protein lifeguard 4PRO_0000179092Add
    BLAST

    Proteomic databases

    PaxDbiQ9HC24.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9HC24.
    BgeeiQ9HC24.
    CleanExiHS_TMBIM4.
    GenevestigatoriQ9HC24.

    Interactioni

    Subunit structurei

    Interacts with ITPR3.1 Publication

    Protein-protein interaction databases

    BioGridi119653. 10 interactions.
    IntActiQ9HC24. 4 interactions.
    STRINGi9606.ENSP00000350965.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HC24.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini60 – 689LumenalSequence Analysis
    Topological domaini90 – 978CytoplasmicSequence Analysis
    Topological domaini119 – 1202LumenalSequence Analysis
    Topological domaini142 – 15110CytoplasmicSequence Analysis
    Topological domaini173 – 1753LumenalSequence Analysis
    Topological domaini197 – 20812CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini230 – 2389CytoplasmicSequence Analysis

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei121 – 14121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BI1 family. LFG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0670.
    HOGENOMiHOG000060393.
    HOVERGENiHBG012084.
    KOiK06890.
    OrthoDBiEOG7MPRFW.
    PhylomeDBiQ9HC24.
    TreeFamiTF321860.

    Family and domain databases

    InterProiIPR006214. Bax_inhibitor_1-related.
    [Graphical view]
    PANTHERiPTHR23291. PTHR23291. 1 hit.
    PfamiPF01027. Bax1-I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HC24-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADPDPRYPR SSIEDDFNYG SSVASATVHI RMAFLRKVYS ILSLQVLLTT    50
    VTSTVFLYFE SVRTFVHESP ALILLFALGS LGLIFALILN RHKYPLNLYL 100
    LFGFTLLEAL TVAVVVTFYD VYIILQAFIL TTTVFFGLTV YTLQSKKDFS 150
    KFGAGLFALL WILCLSGFLK FFFYSEIMEL VLAAAGALLF CGFIIYDTHS 200
    LMHKLSPEEY VLAAISLYLD IINLFLHLLR FLEAVNKK 238
    Length:238
    Mass (Da):26,971
    Last modified:February 8, 2011 - v3
    Checksum:i30CD39CF7F38564E
    GO

    Sequence cautioni

    The sequence AAD34114.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21A → V.
    Corresponds to variant rs11176070 [ dbSNP | Ensembl ].
    VAR_055547
    Natural varianti88 – 881I → T.3 Publications
    Corresponds to variant rs8793 [ dbSNP | Ensembl ].
    VAR_014946

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182041 mRNA. Translation: AAG16898.1.
    AF151877 mRNA. Translation: AAD34114.1. Different initiation.
    AF113127 mRNA. Translation: AAF14868.1.
    AK075069 mRNA. Translation: BAC11384.1.
    AC078927 Genomic DNA. No translation available.
    BC020613 mRNA. No translation available.
    CCDSiCCDS41805.1.
    RefSeqiNP_001269535.1. NM_001282606.1.
    NP_001269538.1. NM_001282609.1.
    NP_001269539.1. NM_001282610.1.
    NP_057140.2. NM_016056.3.
    UniGeneiHs.505934.

    Genome annotation databases

    EnsembliENST00000358230; ENSP00000350965; ENSG00000155957.
    GeneIDi51643.
    KEGGihsa:51643.
    UCSCiuc001stc.3. human.

    Polymorphism databases

    DMDMi322510100.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182041 mRNA. Translation: AAG16898.1 .
    AF151877 mRNA. Translation: AAD34114.1 . Different initiation.
    AF113127 mRNA. Translation: AAF14868.1 .
    AK075069 mRNA. Translation: BAC11384.1 .
    AC078927 Genomic DNA. No translation available.
    BC020613 mRNA. No translation available.
    CCDSi CCDS41805.1.
    RefSeqi NP_001269535.1. NM_001282606.1.
    NP_001269538.1. NM_001282609.1.
    NP_001269539.1. NM_001282610.1.
    NP_057140.2. NM_016056.3.
    UniGenei Hs.505934.

    3D structure databases

    ProteinModelPortali Q9HC24.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119653. 10 interactions.
    IntActi Q9HC24. 4 interactions.
    STRINGi 9606.ENSP00000350965.

    Protein family/group databases

    TCDBi 1.A.14.3.6. the testis-enhanced gene transfer (tegt) family.

    Polymorphism databases

    DMDMi 322510100.

    Proteomic databases

    PaxDbi Q9HC24.

    Protocols and materials databases

    DNASUi 51643.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358230 ; ENSP00000350965 ; ENSG00000155957 .
    GeneIDi 51643.
    KEGGi hsa:51643.
    UCSCi uc001stc.3. human.

    Organism-specific databases

    CTDi 51643.
    GeneCardsi GC12M066531.
    HGNCi HGNC:24257. TMBIM4.
    neXtProti NX_Q9HC24.
    PharmGKBi PA142670805.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0670.
    HOGENOMi HOG000060393.
    HOVERGENi HBG012084.
    KOi K06890.
    OrthoDBi EOG7MPRFW.
    PhylomeDBi Q9HC24.
    TreeFami TF321860.

    Miscellaneous databases

    GeneWikii TMBIM4.
    GenomeRNAii 51643.
    NextBioi 55584.
    PROi Q9HC24.

    Gene expression databases

    ArrayExpressi Q9HC24.
    Bgeei Q9HC24.
    CleanExi HS_TMBIM4.
    Genevestigatori Q9HC24.

    Family and domain databases

    InterProi IPR006214. Bax_inhibitor_1-related.
    [Graphical view ]
    PANTHERi PTHR23291. PTHR23291. 1 hit.
    Pfami PF01027. Bax1-I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and phylogeny of a novel family of eukaryotic membrane proteins related to a glutamate binding protein (GBP)."
      Goldberger O., Smith T., Minta J., Goldberger G.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-88.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-88.
      Tissue: Adrenal gland.
    4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-88.
      Tissue: Placenta.
    5. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "A new inhibitor of apoptosis from vaccinia virus and eukaryotes."
      Gubser C., Bergamaschi D., Hollinshead M., Lu X., van Kuppeveld F.J., Smith G.L.
      PLoS Pathog. 3:E17-E17(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    8. "LFG: a candidate apoptosis regulatory gene family."
      Hu L., Smith T.F., Goldberger G.
      Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    9. Cited for: FUNCTION, INTERACTION WITH ITPR3.
    10. "Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family."
      Carrara G., Saraiva N., Gubser C., Johnson B.F., Smith G.L.
      J. Biol. Chem. 287:15896-15905(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TOPOLOGY.

    Entry informationi

    Entry nameiLFG4_HUMAN
    AccessioniPrimary (citable) accession number: Q9HC24
    Secondary accession number(s): Q542Z6, Q9UHY5, Q9Y3C2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3