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Q9HC24

- LFG4_HUMAN

UniProt

Q9HC24 - LFG4_HUMAN

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Protein

Protein lifeguard 4

Gene
TMBIM4, GAAP, LFG4, CGI-119
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.2 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. negative regulation of apoptotic process Source: UniProtKB
  3. regulation of calcium-mediated signaling Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Protein family/group databases

TCDBi1.A.14.3.6. the testis-enhanced gene transfer (tegt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 4
Alternative name(s):
Golgi anti-apoptotic protein
Protein S1R
Transmembrane BAX inhibitor motif-containing protein 4
Z-protein
Gene namesi
Name:TMBIM4
Synonyms:GAAP, LFG4
ORF Names:CGI-119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:24257. TMBIM4.

Subcellular locationi

Golgi apparatus membrane; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei39 – 5921Helical; Reviewed predictionAdd
BLAST
Topological domaini60 – 689Lumenal Reviewed prediction
Transmembranei69 – 8921Helical; Reviewed predictionAdd
BLAST
Topological domaini90 – 978Cytoplasmic Reviewed prediction
Transmembranei98 – 11821Helical; Reviewed predictionAdd
BLAST
Topological domaini119 – 1202Lumenal Reviewed prediction
Transmembranei121 – 14121Helical; Reviewed predictionAdd
BLAST
Topological domaini142 – 15110Cytoplasmic Reviewed prediction
Transmembranei152 – 17221Helical; Reviewed predictionAdd
BLAST
Topological domaini173 – 1753Lumenal Reviewed prediction
Transmembranei176 – 19621Helical; Reviewed predictionAdd
BLAST
Topological domaini197 – 20812Cytoplasmic Reviewed predictionAdd
BLAST
Intramembranei209 – 22921Helical; Reviewed predictionAdd
BLAST
Topological domaini230 – 2389Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. Golgi stack Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Protein lifeguard 4PRO_0000179092Add
BLAST

Proteomic databases

PaxDbiQ9HC24.

Expressioni

Gene expression databases

ArrayExpressiQ9HC24.
BgeeiQ9HC24.
CleanExiHS_TMBIM4.
GenevestigatoriQ9HC24.

Interactioni

Subunit structurei

Interacts with ITPR3.1 Publication

Protein-protein interaction databases

BioGridi119653. 10 interactions.
IntActiQ9HC24. 4 interactions.
STRINGi9606.ENSP00000350965.

Structurei

3D structure databases

ProteinModelPortaliQ9HC24.

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0670.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
KOiK06890.
OrthoDBiEOG7MPRFW.
PhylomeDBiQ9HC24.
TreeFamiTF321860.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HC24-1 [UniParc]FASTAAdd to Basket

« Hide

MADPDPRYPR SSIEDDFNYG SSVASATVHI RMAFLRKVYS ILSLQVLLTT    50
VTSTVFLYFE SVRTFVHESP ALILLFALGS LGLIFALILN RHKYPLNLYL 100
LFGFTLLEAL TVAVVVTFYD VYIILQAFIL TTTVFFGLTV YTLQSKKDFS 150
KFGAGLFALL WILCLSGFLK FFFYSEIMEL VLAAAGALLF CGFIIYDTHS 200
LMHKLSPEEY VLAAISLYLD IINLFLHLLR FLEAVNKK 238
Length:238
Mass (Da):26,971
Last modified:February 8, 2011 - v3
Checksum:i30CD39CF7F38564E
GO

Sequence cautioni

The sequence AAD34114.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21A → V.
Corresponds to variant rs11176070 [ dbSNP | Ensembl ].
VAR_055547
Natural varianti88 – 881I → T.3 Publications
Corresponds to variant rs8793 [ dbSNP | Ensembl ].
VAR_014946

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF182041 mRNA. Translation: AAG16898.1.
AF151877 mRNA. Translation: AAD34114.1. Different initiation.
AF113127 mRNA. Translation: AAF14868.1.
AK075069 mRNA. Translation: BAC11384.1.
AC078927 Genomic DNA. No translation available.
BC020613 mRNA. No translation available.
CCDSiCCDS41805.1.
RefSeqiNP_001269535.1. NM_001282606.1.
NP_001269538.1. NM_001282609.1.
NP_001269539.1. NM_001282610.1.
NP_057140.2. NM_016056.3.
UniGeneiHs.505934.

Genome annotation databases

EnsembliENST00000358230; ENSP00000350965; ENSG00000155957.
GeneIDi51643.
KEGGihsa:51643.
UCSCiuc001stc.3. human.

Polymorphism databases

DMDMi322510100.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF182041 mRNA. Translation: AAG16898.1 .
AF151877 mRNA. Translation: AAD34114.1 . Different initiation.
AF113127 mRNA. Translation: AAF14868.1 .
AK075069 mRNA. Translation: BAC11384.1 .
AC078927 Genomic DNA. No translation available.
BC020613 mRNA. No translation available.
CCDSi CCDS41805.1.
RefSeqi NP_001269535.1. NM_001282606.1.
NP_001269538.1. NM_001282609.1.
NP_001269539.1. NM_001282610.1.
NP_057140.2. NM_016056.3.
UniGenei Hs.505934.

3D structure databases

ProteinModelPortali Q9HC24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119653. 10 interactions.
IntActi Q9HC24. 4 interactions.
STRINGi 9606.ENSP00000350965.

Protein family/group databases

TCDBi 1.A.14.3.6. the testis-enhanced gene transfer (tegt) family.

Polymorphism databases

DMDMi 322510100.

Proteomic databases

PaxDbi Q9HC24.

Protocols and materials databases

DNASUi 51643.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358230 ; ENSP00000350965 ; ENSG00000155957 .
GeneIDi 51643.
KEGGi hsa:51643.
UCSCi uc001stc.3. human.

Organism-specific databases

CTDi 51643.
GeneCardsi GC12M066531.
HGNCi HGNC:24257. TMBIM4.
neXtProti NX_Q9HC24.
PharmGKBi PA142670805.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0670.
HOGENOMi HOG000060393.
HOVERGENi HBG012084.
KOi K06890.
OrthoDBi EOG7MPRFW.
PhylomeDBi Q9HC24.
TreeFami TF321860.

Miscellaneous databases

GeneWikii TMBIM4.
GenomeRNAii 51643.
NextBioi 55584.
PROi Q9HC24.

Gene expression databases

ArrayExpressi Q9HC24.
Bgeei Q9HC24.
CleanExi HS_TMBIM4.
Genevestigatori Q9HC24.

Family and domain databases

InterProi IPR006214. Bax_inhibitor_1-related.
[Graphical view ]
PANTHERi PTHR23291. PTHR23291. 1 hit.
Pfami PF01027. Bax1-I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and phylogeny of a novel family of eukaryotic membrane proteins related to a glutamate binding protein (GBP)."
    Goldberger O., Smith T., Minta J., Goldberger G.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-88.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-88.
    Tissue: Adrenal gland.
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-88.
    Tissue: Placenta.
  5. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "A new inhibitor of apoptosis from vaccinia virus and eukaryotes."
    Gubser C., Bergamaschi D., Hollinshead M., Lu X., van Kuppeveld F.J., Smith G.L.
    PLoS Pathog. 3:E17-E17(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "LFG: a candidate apoptosis regulatory gene family."
    Hu L., Smith T.F., Goldberger G.
    Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  9. Cited for: FUNCTION, INTERACTION WITH ITPR3.
  10. "Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family."
    Carrara G., Saraiva N., Gubser C., Johnson B.F., Smith G.L.
    J. Biol. Chem. 287:15896-15905(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TOPOLOGY.

Entry informationi

Entry nameiLFG4_HUMAN
AccessioniPrimary (citable) accession number: Q9HC24
Secondary accession number(s): Q542Z6, Q9UHY5, Q9Y3C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: February 8, 2011
Last modified: July 9, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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