Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein lifeguard 4

Gene

TMBIM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.2 Publications

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: UniProtKB
  • regulation of calcium-mediated signaling Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155957-MONOMER.

Protein family/group databases

TCDBi1.A.14.3.6. the testis-enhanced gene transfer (tegt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 4
Alternative name(s):
Golgi anti-apoptotic protein
Protein S1R
Transmembrane BAX inhibitor motif-containing protein 4
Z-protein
Gene namesi
Name:TMBIM4
Synonyms:GAAP, LFG4
ORF Names:CGI-119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24257. TMBIM4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 68LumenalSequence analysis9
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 97CytoplasmicSequence analysis8
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 120LumenalSequence analysis2
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 151CytoplasmicSequence analysis10
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 175LumenalSequence analysis3
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 208CytoplasmicSequence analysisAdd BLAST12
Intramembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 238CytoplasmicSequence analysis9

GO - Cellular componenti

  • Golgi membrane Source: UniProtKB-SubCell
  • Golgi stack Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51643.
OpenTargetsiENSG00000155957.
PharmGKBiPA142670805.

Polymorphism and mutation databases

BioMutaiTMBIM4.
DMDMi322510100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001790921 – 238Protein lifeguard 4Add BLAST238

Proteomic databases

PaxDbiQ9HC24.
PeptideAtlasiQ9HC24.
PRIDEiQ9HC24.

PTM databases

iPTMnetiQ9HC24.
PhosphoSitePlusiQ9HC24.

Expressioni

Gene expression databases

BgeeiENSG00000155957.
CleanExiHS_TMBIM4.
ExpressionAtlasiQ9HC24. baseline and differential.
GenevisibleiQ9HC24. HS.

Interactioni

Subunit structurei

Interacts with ITPR3.1 Publication

Protein-protein interaction databases

BioGridi119653. 10 interactors.
IntActiQ9HC24. 4 interactors.
STRINGi9606.ENSP00000350965.

Structurei

3D structure databases

ProteinModelPortaliQ9HC24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2322. Eukaryota.
COG0670. LUCA.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ9HC24.
KOiK06890.
PhylomeDBiQ9HC24.
TreeFamiTF321860.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HC24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPDPRYPR SSIEDDFNYG SSVASATVHI RMAFLRKVYS ILSLQVLLTT
60 70 80 90 100
VTSTVFLYFE SVRTFVHESP ALILLFALGS LGLIFALILN RHKYPLNLYL
110 120 130 140 150
LFGFTLLEAL TVAVVVTFYD VYIILQAFIL TTTVFFGLTV YTLQSKKDFS
160 170 180 190 200
KFGAGLFALL WILCLSGFLK FFFYSEIMEL VLAAAGALLF CGFIIYDTHS
210 220 230
LMHKLSPEEY VLAAISLYLD IINLFLHLLR FLEAVNKK
Length:238
Mass (Da):26,971
Last modified:February 8, 2011 - v3
Checksum:i30CD39CF7F38564E
GO

Sequence cautioni

The sequence AAD34114 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0555472A → V.Corresponds to variant rs11176070dbSNPEnsembl.1
Natural variantiVAR_01494688I → T.3 PublicationsCorresponds to variant rs8793dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182041 mRNA. Translation: AAG16898.1.
AF151877 mRNA. Translation: AAD34114.1. Different initiation.
AF113127 mRNA. Translation: AAF14868.1.
AK075069 mRNA. Translation: BAC11384.1.
AC078927 Genomic DNA. No translation available.
BC020613 mRNA. No translation available.
CCDSiCCDS41805.1.
RefSeqiNP_001269535.1. NM_001282606.1.
NP_001269538.1. NM_001282609.1.
NP_001269539.1. NM_001282610.1.
NP_057140.2. NM_016056.3.
UniGeneiHs.505934.

Genome annotation databases

EnsembliENST00000358230; ENSP00000350965; ENSG00000155957.
GeneIDi51643.
KEGGihsa:51643.
UCSCiuc001stc.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182041 mRNA. Translation: AAG16898.1.
AF151877 mRNA. Translation: AAD34114.1. Different initiation.
AF113127 mRNA. Translation: AAF14868.1.
AK075069 mRNA. Translation: BAC11384.1.
AC078927 Genomic DNA. No translation available.
BC020613 mRNA. No translation available.
CCDSiCCDS41805.1.
RefSeqiNP_001269535.1. NM_001282606.1.
NP_001269538.1. NM_001282609.1.
NP_001269539.1. NM_001282610.1.
NP_057140.2. NM_016056.3.
UniGeneiHs.505934.

3D structure databases

ProteinModelPortaliQ9HC24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119653. 10 interactors.
IntActiQ9HC24. 4 interactors.
STRINGi9606.ENSP00000350965.

Protein family/group databases

TCDBi1.A.14.3.6. the testis-enhanced gene transfer (tegt) family.

PTM databases

iPTMnetiQ9HC24.
PhosphoSitePlusiQ9HC24.

Polymorphism and mutation databases

BioMutaiTMBIM4.
DMDMi322510100.

Proteomic databases

PaxDbiQ9HC24.
PeptideAtlasiQ9HC24.
PRIDEiQ9HC24.

Protocols and materials databases

DNASUi51643.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358230; ENSP00000350965; ENSG00000155957.
GeneIDi51643.
KEGGihsa:51643.
UCSCiuc001stc.5. human.

Organism-specific databases

CTDi51643.
DisGeNETi51643.
GeneCardsiTMBIM4.
HGNCiHGNC:24257. TMBIM4.
neXtProtiNX_Q9HC24.
OpenTargetsiENSG00000155957.
PharmGKBiPA142670805.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2322. Eukaryota.
COG0670. LUCA.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ9HC24.
KOiK06890.
PhylomeDBiQ9HC24.
TreeFamiTF321860.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155957-MONOMER.

Miscellaneous databases

GeneWikiiTMBIM4.
GenomeRNAii51643.
PROiQ9HC24.

Gene expression databases

BgeeiENSG00000155957.
CleanExiHS_TMBIM4.
ExpressionAtlasiQ9HC24. baseline and differential.
GenevisibleiQ9HC24. HS.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLFG4_HUMAN
AccessioniPrimary (citable) accession number: Q9HC24
Secondary accession number(s): Q542Z6, Q9UHY5, Q9Y3C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: February 8, 2011
Last modified: November 2, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.