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Protein

NADPH oxidase 3

Gene

NOX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.1 Publication

Enzyme regulationi

Activated by the ototoxic drug cisplatin (By similarity). Activated by NOXO1. Cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. Inhibited by diphenyleneiodonium chloride.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

ReactomeiR-HSA-5668599 RHO GTPases Activate NADPH Oxidases

Protein family/group databases

PeroxiBasei5960 HsNOx03
TCDBi5.B.1.1.4 the phagocyte (gp91(phox)) nadph oxidase family

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH oxidase 3 (EC:1.6.3.-)
Alternative name(s):
Mitogenic oxidase 2
Short name:
MOX-2
gp91phox homolog 3
Short name:
GP91-3
Gene namesi
Name:NOX3
Synonyms:MOX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000074771.3
HGNCiHGNC:7890 NOX3
MIMi607105 gene
neXtProtiNX_Q9HBY0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 51ExtracellularSequence analysisAdd BLAST17
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 103CytoplasmicSequence analysisAdd BLAST31
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 167ExtracellularSequence analysisAdd BLAST43
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 201CytoplasmicSequence analysisAdd BLAST13
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 395ExtracellularSequence analysisAdd BLAST173
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 568CytoplasmicSequence analysisAdd BLAST152

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi413P → H: Loss of catalytic activity. 1 Publication1

Organism-specific databases

DisGeNETi50508
OpenTargetsiENSG00000074771
PharmGKBiPA31691

Chemistry databases

ChEMBLiCHEMBL1741216

Polymorphism and mutation databases

BioMutaiNOX3
DMDMi74752785

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002275961 – 568NADPH oxidase 3Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9HBY0
PeptideAtlasiQ9HBY0
PRIDEiQ9HBY0

PTM databases

iPTMnetiQ9HBY0
PhosphoSitePlusiQ9HBY0

Expressioni

Developmental stagei

Expressed in fetal kidney and to a lower extent in liver, lung and spleen.2 Publications

Gene expression databases

BgeeiENSG00000074771
CleanExiHS_NOX3
GenevisibleiQ9HBY0 HS

Organism-specific databases

HPAiHPA073837

Interactioni

Subunit structurei

Interacts with and stabilizes CYBA/p22phox.1 Publication

Protein-protein interaction databases

IntActiQ9HBY0, 1 interactor
STRINGi9606.ENSP00000159060

Structurei

3D structure databases

ProteinModelPortaliQ9HBY0
SMRiQ9HBY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 284Ferric oxidoreductaseAdd BLAST230
Domaini285 – 395FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST111

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0039 Eukaryota
ENOG410XNZY LUCA
GeneTreeiENSGT00550000074350
HOGENOMiHOG000216669
HOVERGENiHBG003760
InParanoidiQ9HBY0
KOiK21422
OMAiGCWILNE
OrthoDBiEOG091G09RV
PhylomeDBiQ9HBY0
TreeFamiTF105354

Family and domain databases

InterProiView protein in InterPro
IPR000778 Cyt_b245_heavy_chain
IPR013112 FAD-bd_8
IPR017927 Fd_Rdtase_FAD-bd
IPR013130 Fe3_Rdtase_TM_dom
IPR013121 Fe_red_NAD-bd_6
IPR029653 NOX3
IPR017938 Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF12 PTHR11972:SF12, 1 hit
PfamiView protein in Pfam
PF08022 FAD_binding_8, 1 hit
PF01794 Ferric_reduct, 1 hit
PF08030 NAD_binding_6, 1 hit
PRINTSiPR00466 GP91PHOX
SUPFAMiSSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HBY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGCWILNEG LSTILVLSWL GINFYLFIDT FYWYEEEESF HYTRVILGST
60 70 80 90 100
LAWARASALC LNFNCMLILI PVSRNLISFI RGTSICCRGP WRRQLDKNLR
110 120 130 140 150
FHKLVAYGIA VNATIHIVAH FFNLERYHWS QSEEAQGLLA ALSKLGNTPN
160 170 180 190 200
ESYLNPVRTF PTNTTTELLR TIAGVTGLVI SLALVLIMTS STEFIRQASY
210 220 230 240 250
ELFWYTHHVF IVFFLSLAIH GTGRIVRGQT QDSLSLHNIT FCRDRYAEWQ
260 270 280 290 300
TVAQCPVPQF SGKEPSAWKW ILGPVVLYAC ERIIRFWRFQ QEVVITKVVS
310 320 330 340 350
HPSGVLELHM KKRGFKMAPG QYILVQCPAI SSLEWHPFTL TSAPQEDFFS
360 370 380 390 400
VHIRAAGDWT AALLEAFGAE GQALQEPWSL PRLAVDGPFG TALTDVFHYP
410 420 430 440 450
VCVCVAAGIG VTPFAALLKS IWYKCSEAQT PLKLSKVYFY WICRDARAFE
460 470 480 490 500
WFADLLLSLE TRMSEQGKTH FLSYHIFLTG WDENQALHIA LHWDENTDVI
510 520 530 540 550
TGLKQKTFYG RPNWNNEFKQ IAYNHPSSSI GVFFCGPKAL SRTLQKMCHL
560
YSSADPRGVH FYYNKESF
Length:568
Mass (Da):64,935
Last modified:March 1, 2001 - v1
Checksum:i10BCD6BEB18D0583
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti328P → S in AAG15435 (PubMed:10974555).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049103171T → K. Corresponds to variant dbSNP:rs3749930Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190122 mRNA Translation: AAG17121.1
AL031773 Genomic DNA No translation available.
AF229177 mRNA Translation: AAG15435.1
CCDSiCCDS5250.1
RefSeqiNP_056533.1, NM_015718.2
UniGeneiHs.247776

Genome annotation databases

EnsembliENST00000159060; ENSP00000159060; ENSG00000074771
GeneIDi50508
KEGGihsa:50508
UCSCiuc003qqm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNOX3_HUMAN
AccessioniPrimary (citable) accession number: Q9HBY0
Secondary accession number(s): Q9HBJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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