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Q9HBW9

- ELTD1_HUMAN

UniProt

Q9HBW9 - ELTD1_HUMAN

Protein

EGF, latrophilin and seven transmembrane domain-containing protein 1

Gene

ELTD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Could be involved in cardiac development.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei406 – 4072CleavageBy similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. G-protein coupled receptor activity Source: GDB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: GDB
    2. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Calcium

    Protein family/group databases

    MEROPSiS63.016.
    TCDBi9.A.14.6.3. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EGF, latrophilin and seven transmembrane domain-containing protein 1
    Alternative name(s):
    EGF-TM7-latrophilin-related protein
    Short name:
    ETL protein
    Gene namesi
    Name:ELTD1
    Synonyms:ETL
    ORF Names:UNQ202/PRO228
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:20822. ELTD1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: GDB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134946418.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 690671EGF, latrophilin and seven transmembrane domain-containing protein 1PRO_0000012870Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi22 ↔ 33PROSITE-ProRule annotation
    Disulfide bondi27 ↔ 42PROSITE-ProRule annotation
    Disulfide bondi44 ↔ 56PROSITE-ProRule annotation
    Disulfide bondi62 ↔ 75PROSITE-ProRule annotation
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi69 ↔ 84PROSITE-ProRule annotation
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi86 ↔ 107PROSITE-ProRule annotation
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi249 – 2491N-linked (GlcNAc...)1 Publication
    Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9HBW9.
    PRIDEiQ9HBW9.

    PTM databases

    PhosphoSiteiQ9HBW9.

    Expressioni

    Tissue specificityi

    Mainly expressed in smooth muscle.

    Developmental stagei

    Up-regulated in the adult heart.

    Gene expression databases

    ArrayExpressiQ9HBW9.
    BgeeiQ9HBW9.
    CleanExiHS_ELTD1.
    GenevestigatoriQ9HBW9.

    Organism-specific databases

    HPAiHPA025229.

    Interactioni

    Subunit structurei

    Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Forms stable dimer at the cells surface By similarity.By similarity

    Protein-protein interaction databases

    BioGridi122076. 1 interaction.
    IntActiQ9HBW9. 1 interaction.
    STRINGi9606.ENSP00000359778.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HBW9.
    SMRiQ9HBW9. Positions 22-406, 453-674.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 432413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini454 – 4607CytoplasmicSequence Analysis
    Topological domaini482 – 49918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini521 – 53212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini554 – 57320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini595 – 61824CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini640 – 6467ExtracellularSequence Analysis
    Topological domaini668 – 69023CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei433 – 45321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei461 – 48121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei500 – 52021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei533 – 55321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei574 – 59421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei619 – 63921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei647 – 66721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 5738EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini58 – 10851EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini367 – 41852GPSPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi326 – 3294Poly-Glu

    Domaini

    The transmembrane domain is not required for cleavage, but it is required for dimer formation.By similarity

    Sequence similaritiesi

    Contains 2 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 GPS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG276724.
    HOGENOMiHOG000112361.
    HOVERGENiHBG101117.
    InParanoidiQ9HBW9.
    KOiK04595.
    OMAiHLTKLMH.
    OrthoDBiEOG76DTRK.
    PhylomeDBiQ9HBW9.
    TreeFamiTF316380.

    Family and domain databases

    Gene3Di2.40.155.10. 1 hit.
    InterProiIPR022624. DUF3497.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR023413. GFP_like.
    IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    SMARTiSM00181. EGF. 1 hit.
    SM00179. EGF_CA. 1 hit.
    SM00303. GPS. 1 hit.
    [Graphical view]
    PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
    PS00018. EF_HAND_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 2 hits.
    PS01187. EGF_CA. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9HBW9-1 [UniParc]FASTAAdd to Basket

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    MKRLPLLVVF STLLNCSYTQ NCTKTPCLPN AKCEIRNGIE ACYCNMGFSG    50
    NGVTICEDDN ECGNLTQSCG ENANCTNTEG SYYCMCVPGF RSSSNQDRFI 100
    TNDGTVCIEN VNANCHLDNV CIAANINKTL TKIRSIKEPV ALLQEVYRNS 150
    VTDLSPTDII TYIEILAESS SLLGYKNNTI SAKDTLSNST LTEFVKTVNN 200
    FVQRDTFVVW DKLSVNHRRT HLTKLMHTVE QATLRISQSF QKTTEFDTNS 250
    TDIALKVFFF DSYNMKHIHP HMNMDGDYIN IFPKRKAAYD SNGNVAVAFV 300
    YYKSIGPLLS SSDNFLLKPQ NYDNSEEEER VISSVISVSM SSNPPTLYEL 350
    EKITFTLSHR KVTDRYRSLC AFWNYSPDTM NGSWSSEGCE LTYSNETHTS 400
    CRCNHLTHFA ILMSSGPSIG IKDYNILTRI TQLGIIISLI CLAICIFTFW 450
    FFSEIQSTRT TIHKNLCCSL FLAELVFLVG INTNTNKLFC SIIAGLLHYF 500
    FLAAFAWMCI EGIHLYLIVV GVIYNKGFLH KNFYIFGYLS PAVVVGFSAA 550
    LGYRYYGTTK VCWLSTENNF IWSFIGPACL IILVNLLAFG VIIYKVFRHT 600
    AGLKPEVSCF ENIRSCARGA LALLFLLGTT WIFGVLHVVH ASVVTAYLFT 650
    VSNAFQGMFI FLFLCVLSRK IQEEYYRLFK NVPCCFGCLR 690
    Length:690
    Mass (Da):77,811
    Last modified:November 4, 2008 - v3
    Checksum:i38BFEEBCEADDEFC8
    GO

    Sequence cautioni

    The sequence AAG33021.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH25721.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti300 – 3001V → L.3 Publications
    Corresponds to variant rs12754818 [ dbSNP | Ensembl ].
    VAR_047072
    Natural varianti599 – 5991H → Q.
    Corresponds to variant rs1968956 [ dbSNP | Ensembl ].
    VAR_047073
    Natural varianti620 – 6201A → G.1 Publication
    Corresponds to variant rs2275902 [ dbSNP | Ensembl ].
    VAR_047074

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032017 mRNA. Translation: BAD83584.1.
    AY358360 mRNA. Translation: AAQ88726.1.
    AL596269, AC098651, AC099674 Genomic DNA. Translation: CAI13205.1.
    CH471059 Genomic DNA. Translation: EAX06345.1.
    BC025721 mRNA. Translation: AAH25721.1. Different initiation.
    AF192403 mRNA. Translation: AAG33021.1. Different initiation.
    CCDSiCCDS41352.1.
    RefSeqiNP_071442.2. NM_022159.3.
    UniGeneiHs.132314.

    Genome annotation databases

    EnsembliENST00000370742; ENSP00000359778; ENSG00000162618.
    GeneIDi64123.
    KEGGihsa:64123.
    UCSCiuc001diq.4. human.

    Polymorphism databases

    DMDMi212276505.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032017 mRNA. Translation: BAD83584.1 .
    AY358360 mRNA. Translation: AAQ88726.1 .
    AL596269 , AC098651 , AC099674 Genomic DNA. Translation: CAI13205.1 .
    CH471059 Genomic DNA. Translation: EAX06345.1 .
    BC025721 mRNA. Translation: AAH25721.1 . Different initiation.
    AF192403 mRNA. Translation: AAG33021.1 . Different initiation.
    CCDSi CCDS41352.1.
    RefSeqi NP_071442.2. NM_022159.3.
    UniGenei Hs.132314.

    3D structure databases

    ProteinModelPortali Q9HBW9.
    SMRi Q9HBW9. Positions 22-406, 453-674.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122076. 1 interaction.
    IntActi Q9HBW9. 1 interaction.
    STRINGi 9606.ENSP00000359778.

    Protein family/group databases

    MEROPSi S63.016.
    TCDBi 9.A.14.6.3. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9HBW9.

    Polymorphism databases

    DMDMi 212276505.

    Proteomic databases

    PaxDbi Q9HBW9.
    PRIDEi Q9HBW9.

    Protocols and materials databases

    DNASUi 64123.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370742 ; ENSP00000359778 ; ENSG00000162618 .
    GeneIDi 64123.
    KEGGi hsa:64123.
    UCSCi uc001diq.4. human.

    Organism-specific databases

    CTDi 64123.
    GeneCardsi GC01M079355.
    H-InvDB HIX0000724.
    HGNCi HGNC:20822. ELTD1.
    HPAi HPA025229.
    neXtProti NX_Q9HBW9.
    PharmGKBi PA134946418.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG276724.
    HOGENOMi HOG000112361.
    HOVERGENi HBG101117.
    InParanoidi Q9HBW9.
    KOi K04595.
    OMAi HLTKLMH.
    OrthoDBi EOG76DTRK.
    PhylomeDBi Q9HBW9.
    TreeFami TF316380.

    Miscellaneous databases

    GeneWikii ELTD1.
    GenomeRNAii 64123.
    NextBioi 66004.
    PROi Q9HBW9.

    Gene expression databases

    ArrayExpressi Q9HBW9.
    Bgeei Q9HBW9.
    CleanExi HS_ELTD1.
    Genevestigatori Q9HBW9.

    Family and domain databases

    Gene3Di 2.40.155.10. 1 hit.
    InterProi IPR022624. DUF3497.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR023413. GFP_like.
    IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    SMARTi SM00181. EGF. 1 hit.
    SM00179. EGF_CA. 1 hit.
    SM00303. GPS. 1 hit.
    [Graphical view ]
    PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
    PS00018. EF_HAND_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 2 hits.
    PS01187. EGF_CA. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Probable G-protein coupled receptor."
      Hirose M., Urakawa I., Yamano S., Okazaki H.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-620.
      Tissue: Bone marrow.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-300.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-300.
      Tissue: Pancreas.
    6. "ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart."
      Nechiporuk T., Urness L.D., Keating M.T.
      J. Biol. Chem. 276:4150-4157(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 67-690, VARIANT LEU-300.
    7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-249.
      Tissue: Plasma.

    Entry informationi

    Entry nameiELTD1_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBW9
    Secondary accession number(s): B1AR71, Q5KU34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3