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Q9HBW9

- ELTD1_HUMAN

UniProt

Q9HBW9 - ELTD1_HUMAN

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Protein

EGF, latrophilin and seven transmembrane domain-containing protein 1

Gene

ELTD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Could be involved in cardiac development.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei406 – 4072CleavageBy similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. G-protein coupled receptor activity Source: GDB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Protein family/group databases

MEROPSiI63.001.
TCDBi9.A.14.6.3. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
EGF, latrophilin and seven transmembrane domain-containing protein 1
Alternative name(s):
EGF-TM7-latrophilin-related protein
Short name:
ETL protein
Gene namesi
Name:ELTD1
Synonyms:ETL
ORF Names:UNQ202/PRO228
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20822. ELTD1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134946418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 690671EGF, latrophilin and seven transmembrane domain-containing protein 1PRO_0000012870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi22 ↔ 33PROSITE-ProRule annotation
Disulfide bondi27 ↔ 42PROSITE-ProRule annotation
Disulfide bondi44 ↔ 56PROSITE-ProRule annotation
Disulfide bondi62 ↔ 75PROSITE-ProRule annotation
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi69 ↔ 84PROSITE-ProRule annotation
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi86 ↔ 107PROSITE-ProRule annotation
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi249 – 2491N-linked (GlcNAc...)1 Publication
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9HBW9.
PRIDEiQ9HBW9.

PTM databases

PhosphoSiteiQ9HBW9.

Expressioni

Tissue specificityi

Mainly expressed in smooth muscle.

Developmental stagei

Up-regulated in the adult heart.

Gene expression databases

BgeeiQ9HBW9.
CleanExiHS_ELTD1.
ExpressionAtlasiQ9HBW9. baseline and differential.
GenevestigatoriQ9HBW9.

Organism-specific databases

HPAiHPA025229.

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Forms stable dimer at the cells surface (By similarity).By similarity

Protein-protein interaction databases

BioGridi122076. 1 interaction.
IntActiQ9HBW9. 1 interaction.
STRINGi9606.ENSP00000359778.

Structurei

3D structure databases

ProteinModelPortaliQ9HBW9.
SMRiQ9HBW9. Positions 15-406, 453-674.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 432413ExtracellularSequence AnalysisAdd
BLAST
Topological domaini454 – 4607CytoplasmicSequence Analysis
Topological domaini482 – 49918ExtracellularSequence AnalysisAdd
BLAST
Topological domaini521 – 53212CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini554 – 57320ExtracellularSequence AnalysisAdd
BLAST
Topological domaini595 – 61824CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini640 – 6467ExtracellularSequence Analysis
Topological domaini668 – 69023CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei433 – 45321Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei461 – 48121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei500 – 52021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei533 – 55321Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei574 – 59421Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei619 – 63921Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei647 – 66721Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 5738EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini58 – 10851EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini367 – 41852GPSPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi326 – 3294Poly-Glu

Domaini

The transmembrane domain is not required for cleavage, but it is required for dimer formation.By similarity

Sequence similaritiesi

Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276724.
GeneTreeiENSGT00760000118787.
HOGENOMiHOG000112361.
HOVERGENiHBG101117.
InParanoidiQ9HBW9.
KOiK04595.
OMAiHLTKLMH.
OrthoDBiEOG76DTRK.
PhylomeDBiQ9HBW9.
TreeFamiTF316380.

Family and domain databases

Gene3Di2.40.155.10. 1 hit.
InterProiIPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP_like.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF07645. EGF_CA. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HBW9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRLPLLVVF STLLNCSYTQ NCTKTPCLPN AKCEIRNGIE ACYCNMGFSG
60 70 80 90 100
NGVTICEDDN ECGNLTQSCG ENANCTNTEG SYYCMCVPGF RSSSNQDRFI
110 120 130 140 150
TNDGTVCIEN VNANCHLDNV CIAANINKTL TKIRSIKEPV ALLQEVYRNS
160 170 180 190 200
VTDLSPTDII TYIEILAESS SLLGYKNNTI SAKDTLSNST LTEFVKTVNN
210 220 230 240 250
FVQRDTFVVW DKLSVNHRRT HLTKLMHTVE QATLRISQSF QKTTEFDTNS
260 270 280 290 300
TDIALKVFFF DSYNMKHIHP HMNMDGDYIN IFPKRKAAYD SNGNVAVAFV
310 320 330 340 350
YYKSIGPLLS SSDNFLLKPQ NYDNSEEEER VISSVISVSM SSNPPTLYEL
360 370 380 390 400
EKITFTLSHR KVTDRYRSLC AFWNYSPDTM NGSWSSEGCE LTYSNETHTS
410 420 430 440 450
CRCNHLTHFA ILMSSGPSIG IKDYNILTRI TQLGIIISLI CLAICIFTFW
460 470 480 490 500
FFSEIQSTRT TIHKNLCCSL FLAELVFLVG INTNTNKLFC SIIAGLLHYF
510 520 530 540 550
FLAAFAWMCI EGIHLYLIVV GVIYNKGFLH KNFYIFGYLS PAVVVGFSAA
560 570 580 590 600
LGYRYYGTTK VCWLSTENNF IWSFIGPACL IILVNLLAFG VIIYKVFRHT
610 620 630 640 650
AGLKPEVSCF ENIRSCARGA LALLFLLGTT WIFGVLHVVH ASVVTAYLFT
660 670 680 690
VSNAFQGMFI FLFLCVLSRK IQEEYYRLFK NVPCCFGCLR
Length:690
Mass (Da):77,811
Last modified:November 4, 2008 - v3
Checksum:i38BFEEBCEADDEFC8
GO

Sequence cautioni

The sequence AAG33021.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH25721.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti300 – 3001V → L.3 Publications
Corresponds to variant rs12754818 [ dbSNP | Ensembl ].
VAR_047072
Natural varianti599 – 5991H → Q.
Corresponds to variant rs1968956 [ dbSNP | Ensembl ].
VAR_047073
Natural varianti620 – 6201A → G.1 Publication
Corresponds to variant rs2275902 [ dbSNP | Ensembl ].
VAR_047074

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032017 mRNA. Translation: BAD83584.1.
AY358360 mRNA. Translation: AAQ88726.1.
AL596269, AC098651, AC099674 Genomic DNA. Translation: CAI13205.1.
CH471059 Genomic DNA. Translation: EAX06345.1.
BC025721 mRNA. Translation: AAH25721.1. Different initiation.
AF192403 mRNA. Translation: AAG33021.1. Different initiation.
CCDSiCCDS41352.1.
RefSeqiNP_071442.2. NM_022159.3.
UniGeneiHs.132314.

Genome annotation databases

EnsembliENST00000370742; ENSP00000359778; ENSG00000162618.
GeneIDi64123.
KEGGihsa:64123.
UCSCiuc001diq.4. human.

Polymorphism databases

DMDMi212276505.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032017 mRNA. Translation: BAD83584.1 .
AY358360 mRNA. Translation: AAQ88726.1 .
AL596269 , AC098651 , AC099674 Genomic DNA. Translation: CAI13205.1 .
CH471059 Genomic DNA. Translation: EAX06345.1 .
BC025721 mRNA. Translation: AAH25721.1 . Different initiation.
AF192403 mRNA. Translation: AAG33021.1 . Different initiation.
CCDSi CCDS41352.1.
RefSeqi NP_071442.2. NM_022159.3.
UniGenei Hs.132314.

3D structure databases

ProteinModelPortali Q9HBW9.
SMRi Q9HBW9. Positions 15-406, 453-674.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122076. 1 interaction.
IntActi Q9HBW9. 1 interaction.
STRINGi 9606.ENSP00000359778.

Protein family/group databases

MEROPSi I63.001.
TCDBi 9.A.14.6.3. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei Q9HBW9.

Polymorphism databases

DMDMi 212276505.

Proteomic databases

PaxDbi Q9HBW9.
PRIDEi Q9HBW9.

Protocols and materials databases

DNASUi 64123.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370742 ; ENSP00000359778 ; ENSG00000162618 .
GeneIDi 64123.
KEGGi hsa:64123.
UCSCi uc001diq.4. human.

Organism-specific databases

CTDi 64123.
GeneCardsi GC01M079355.
H-InvDB HIX0000724.
HGNCi HGNC:20822. ELTD1.
HPAi HPA025229.
neXtProti NX_Q9HBW9.
PharmGKBi PA134946418.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276724.
GeneTreei ENSGT00760000118787.
HOGENOMi HOG000112361.
HOVERGENi HBG101117.
InParanoidi Q9HBW9.
KOi K04595.
OMAi HLTKLMH.
OrthoDBi EOG76DTRK.
PhylomeDBi Q9HBW9.
TreeFami TF316380.

Miscellaneous databases

GeneWikii ELTD1.
GenomeRNAii 64123.
NextBioi 66004.
PROi Q9HBW9.

Gene expression databases

Bgeei Q9HBW9.
CleanExi HS_ELTD1.
ExpressionAtlasi Q9HBW9. baseline and differential.
Genevestigatori Q9HBW9.

Family and domain databases

Gene3Di 2.40.155.10. 1 hit.
InterProi IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP_like.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF07645. EGF_CA. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view ]
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Probable G-protein coupled receptor."
    Hirose M., Urakawa I., Yamano S., Okazaki H.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-620.
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-300.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-300.
    Tissue: Pancreas.
  6. "ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart."
    Nechiporuk T., Urness L.D., Keating M.T.
    J. Biol. Chem. 276:4150-4157(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 67-690, VARIANT LEU-300.
  7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-249.
    Tissue: Plasma.

Entry informationi

Entry nameiELTD1_HUMAN
AccessioniPrimary (citable) accession number: Q9HBW9
Secondary accession number(s): B1AR71, Q5KU34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 4, 2008
Last modified: October 29, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3