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Q9HBW9

- ELTD1_HUMAN

UniProt

Q9HBW9 - ELTD1_HUMAN

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Protein
EGF, latrophilin and seven transmembrane domain-containing protein 1
Gene
ELTD1, ETL, UNQ202/PRO228
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Could be involved in cardiac development.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei406 – 4072Cleavage By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB
  2. calcium ion binding Source: InterPro

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Protein family/group databases

MEROPSiS63.016.
TCDBi9.A.14.6.3. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
EGF, latrophilin and seven transmembrane domain-containing protein 1
Alternative name(s):
EGF-TM7-latrophilin-related protein
Short name:
ETL protein
Gene namesi
Name:ELTD1
Synonyms:ETL
ORF Names:UNQ202/PRO228
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20822. ELTD1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 432413Extracellular Reviewed prediction
Add
BLAST
Transmembranei433 – 45321Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini454 – 4607Cytoplasmic Reviewed prediction
Transmembranei461 – 48121Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini482 – 49918Extracellular Reviewed prediction
Add
BLAST
Transmembranei500 – 52021Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini521 – 53212Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei533 – 55321Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini554 – 57320Extracellular Reviewed prediction
Add
BLAST
Transmembranei574 – 59421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini595 – 61824Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei619 – 63921Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini640 – 6467Extracellular Reviewed prediction
Transmembranei647 – 66721Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini668 – 69023Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134946418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 690671EGF, latrophilin and seven transmembrane domain-containing protein 1
PRO_0000012870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21 – 211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi22 ↔ 33 By similarity
Disulfide bondi27 ↔ 42 By similarity
Disulfide bondi44 ↔ 56 By similarity
Disulfide bondi62 ↔ 75 By similarity
Glycosylationi64 – 641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi69 ↔ 84 By similarity
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi86 ↔ 107 By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi249 – 2491N-linked (GlcNAc...)1 Publication
Glycosylationi381 – 3811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi395 – 3951N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9HBW9.
PRIDEiQ9HBW9.

PTM databases

PhosphoSiteiQ9HBW9.

Expressioni

Tissue specificityi

Mainly expressed in smooth muscle.

Developmental stagei

Up-regulated in the adult heart.

Gene expression databases

ArrayExpressiQ9HBW9.
BgeeiQ9HBW9.
CleanExiHS_ELTD1.
GenevestigatoriQ9HBW9.

Organism-specific databases

HPAiHPA025229.

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Forms stable dimer at the cells surface By similarity.

Protein-protein interaction databases

BioGridi122076. 1 interaction.
IntActiQ9HBW9. 1 interaction.
STRINGi9606.ENSP00000359778.

Structurei

3D structure databases

ProteinModelPortaliQ9HBW9.
SMRiQ9HBW9. Positions 22-406, 453-674.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 5738EGF-like 1
Add
BLAST
Domaini58 – 10851EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini367 – 41852GPS
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi326 – 3294Poly-Glu

Domaini

The transmembrane domain is not required for cleavage, but it is required for dimer formation By similarity.

Sequence similaritiesi

Contains 2 EGF-like domains.
Contains 1 GPS domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276724.
HOGENOMiHOG000112361.
HOVERGENiHBG101117.
InParanoidiQ9HBW9.
KOiK04595.
OMAiHLTKLMH.
OrthoDBiEOG76DTRK.
PhylomeDBiQ9HBW9.
TreeFamiTF316380.

Family and domain databases

Gene3Di2.40.155.10. 1 hit.
InterProiIPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP_like.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF07645. EGF_CA. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HBW9-1 [UniParc]FASTAAdd to Basket

« Hide

MKRLPLLVVF STLLNCSYTQ NCTKTPCLPN AKCEIRNGIE ACYCNMGFSG    50
NGVTICEDDN ECGNLTQSCG ENANCTNTEG SYYCMCVPGF RSSSNQDRFI 100
TNDGTVCIEN VNANCHLDNV CIAANINKTL TKIRSIKEPV ALLQEVYRNS 150
VTDLSPTDII TYIEILAESS SLLGYKNNTI SAKDTLSNST LTEFVKTVNN 200
FVQRDTFVVW DKLSVNHRRT HLTKLMHTVE QATLRISQSF QKTTEFDTNS 250
TDIALKVFFF DSYNMKHIHP HMNMDGDYIN IFPKRKAAYD SNGNVAVAFV 300
YYKSIGPLLS SSDNFLLKPQ NYDNSEEEER VISSVISVSM SSNPPTLYEL 350
EKITFTLSHR KVTDRYRSLC AFWNYSPDTM NGSWSSEGCE LTYSNETHTS 400
CRCNHLTHFA ILMSSGPSIG IKDYNILTRI TQLGIIISLI CLAICIFTFW 450
FFSEIQSTRT TIHKNLCCSL FLAELVFLVG INTNTNKLFC SIIAGLLHYF 500
FLAAFAWMCI EGIHLYLIVV GVIYNKGFLH KNFYIFGYLS PAVVVGFSAA 550
LGYRYYGTTK VCWLSTENNF IWSFIGPACL IILVNLLAFG VIIYKVFRHT 600
AGLKPEVSCF ENIRSCARGA LALLFLLGTT WIFGVLHVVH ASVVTAYLFT 650
VSNAFQGMFI FLFLCVLSRK IQEEYYRLFK NVPCCFGCLR 690
Length:690
Mass (Da):77,811
Last modified:November 4, 2008 - v3
Checksum:i38BFEEBCEADDEFC8
GO

Sequence cautioni

The sequence AAG33021.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH25721.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti300 – 3001V → L.3 Publications
Corresponds to variant rs12754818 [ dbSNP | Ensembl ].
VAR_047072
Natural varianti599 – 5991H → Q.
Corresponds to variant rs1968956 [ dbSNP | Ensembl ].
VAR_047073
Natural varianti620 – 6201A → G.1 Publication
Corresponds to variant rs2275902 [ dbSNP | Ensembl ].
VAR_047074

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032017 mRNA. Translation: BAD83584.1.
AY358360 mRNA. Translation: AAQ88726.1.
AL596269, AC098651, AC099674 Genomic DNA. Translation: CAI13205.1.
CH471059 Genomic DNA. Translation: EAX06345.1.
BC025721 mRNA. Translation: AAH25721.1. Different initiation.
AF192403 mRNA. Translation: AAG33021.1. Different initiation.
CCDSiCCDS41352.1.
RefSeqiNP_071442.2. NM_022159.3.
UniGeneiHs.132314.

Genome annotation databases

EnsembliENST00000370742; ENSP00000359778; ENSG00000162618.
GeneIDi64123.
KEGGihsa:64123.
UCSCiuc001diq.4. human.

Polymorphism databases

DMDMi212276505.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032017 mRNA. Translation: BAD83584.1 .
AY358360 mRNA. Translation: AAQ88726.1 .
AL596269 , AC098651 , AC099674 Genomic DNA. Translation: CAI13205.1 .
CH471059 Genomic DNA. Translation: EAX06345.1 .
BC025721 mRNA. Translation: AAH25721.1 . Different initiation.
AF192403 mRNA. Translation: AAG33021.1 . Different initiation.
CCDSi CCDS41352.1.
RefSeqi NP_071442.2. NM_022159.3.
UniGenei Hs.132314.

3D structure databases

ProteinModelPortali Q9HBW9.
SMRi Q9HBW9. Positions 22-406, 453-674.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122076. 1 interaction.
IntActi Q9HBW9. 1 interaction.
STRINGi 9606.ENSP00000359778.

Protein family/group databases

MEROPSi S63.016.
TCDBi 9.A.14.6.3. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei Q9HBW9.

Polymorphism databases

DMDMi 212276505.

Proteomic databases

PaxDbi Q9HBW9.
PRIDEi Q9HBW9.

Protocols and materials databases

DNASUi 64123.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370742 ; ENSP00000359778 ; ENSG00000162618 .
GeneIDi 64123.
KEGGi hsa:64123.
UCSCi uc001diq.4. human.

Organism-specific databases

CTDi 64123.
GeneCardsi GC01M079355.
H-InvDB HIX0000724.
HGNCi HGNC:20822. ELTD1.
HPAi HPA025229.
neXtProti NX_Q9HBW9.
PharmGKBi PA134946418.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276724.
HOGENOMi HOG000112361.
HOVERGENi HBG101117.
InParanoidi Q9HBW9.
KOi K04595.
OMAi HLTKLMH.
OrthoDBi EOG76DTRK.
PhylomeDBi Q9HBW9.
TreeFami TF316380.

Miscellaneous databases

GeneWikii ELTD1.
GenomeRNAii 64123.
NextBioi 66004.
PROi Q9HBW9.

Gene expression databases

ArrayExpressi Q9HBW9.
Bgeei Q9HBW9.
CleanExi HS_ELTD1.
Genevestigatori Q9HBW9.

Family and domain databases

Gene3Di 2.40.155.10. 1 hit.
InterProi IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP_like.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF07645. EGF_CA. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view ]
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Probable G-protein coupled receptor."
    Hirose M., Urakawa I., Yamano S., Okazaki H.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-620.
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-300.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-300.
    Tissue: Pancreas.
  6. "ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart."
    Nechiporuk T., Urness L.D., Keating M.T.
    J. Biol. Chem. 276:4150-4157(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 67-690, VARIANT LEU-300.
  7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-249.
    Tissue: Plasma.

Entry informationi

Entry nameiELTD1_HUMAN
AccessioniPrimary (citable) accession number: Q9HBW9
Secondary accession number(s): B1AR71, Q5KU34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 4, 2008
Last modified: July 9, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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