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Q9HBW9 (ELTD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
EGF, latrophilin and seven transmembrane domain-containing protein 1
Alternative name(s):
EGF-TM7-latrophilin-related protein
Short name=ETL protein
Gene names
Name:ELTD1
Synonyms:ETL
ORF Names:UNQ202/PRO228
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length690 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Could be involved in cardiac development.

Subunit structure

Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Forms stable dimer at the cells surface By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Mainly expressed in smooth muscle.

Developmental stage

Up-regulated in the adult heart.

Domain

The transmembrane domain is not required for cleavage, but it is required for dimer formation By similarity.

Post-translational modification

Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 2 EGF-like domains.

Contains 1 GPS domain.

Sequence caution

The sequence AAG33021.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH25721.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 690671EGF, latrophilin and seven transmembrane domain-containing protein 1
PRO_0000012870

Regions

Topological domain20 – 432413Extracellular Potential
Transmembrane433 – 45321Helical; Name=1; Potential
Topological domain454 – 4607Cytoplasmic Potential
Transmembrane461 – 48121Helical; Name=2; Potential
Topological domain482 – 49918Extracellular Potential
Transmembrane500 – 52021Helical; Name=3; Potential
Topological domain521 – 53212Cytoplasmic Potential
Transmembrane533 – 55321Helical; Name=4; Potential
Topological domain554 – 57320Extracellular Potential
Transmembrane574 – 59421Helical; Name=5; Potential
Topological domain595 – 61824Cytoplasmic Potential
Transmembrane619 – 63921Helical; Name=6; Potential
Topological domain640 – 6467Extracellular Potential
Transmembrane647 – 66721Helical; Name=7; Potential
Topological domain668 – 69023Cytoplasmic Potential
Domain20 – 5738EGF-like 1
Domain58 – 10851EGF-like 2; calcium-binding Potential
Domain367 – 41852GPS
Compositional bias326 – 3294Poly-Glu

Sites

Site406 – 4072Cleavage By similarity

Amino acid modifications

Glycosylation151N-linked (GlcNAc...) Potential
Glycosylation211N-linked (GlcNAc...) Potential
Glycosylation641N-linked (GlcNAc...) Potential
Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation1271N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential
Glycosylation2491N-linked (GlcNAc...) Ref.7
Glycosylation3811N-linked (GlcNAc...) Potential
Glycosylation3951N-linked (GlcNAc...) Potential
Disulfide bond22 ↔ 33 By similarity
Disulfide bond27 ↔ 42 By similarity
Disulfide bond44 ↔ 56 By similarity
Disulfide bond62 ↔ 75 By similarity
Disulfide bond69 ↔ 84 By similarity
Disulfide bond86 ↔ 107 By similarity

Natural variations

Natural variant3001V → L. Ref.2 Ref.5 Ref.6
Corresponds to variant rs12754818 [ dbSNP | Ensembl ].
VAR_047072
Natural variant5991H → Q.
Corresponds to variant rs1968956 [ dbSNP | Ensembl ].
VAR_047073
Natural variant6201A → G. Ref.1
Corresponds to variant rs2275902 [ dbSNP | Ensembl ].
VAR_047074

Sequences

Sequence LengthMass (Da)Tools
Q9HBW9 [UniParc].

Last modified November 4, 2008. Version 3.
Checksum: 38BFEEBCEADDEFC8

FASTA69077,811
        10         20         30         40         50         60 
MKRLPLLVVF STLLNCSYTQ NCTKTPCLPN AKCEIRNGIE ACYCNMGFSG NGVTICEDDN 

        70         80         90        100        110        120 
ECGNLTQSCG ENANCTNTEG SYYCMCVPGF RSSSNQDRFI TNDGTVCIEN VNANCHLDNV 

       130        140        150        160        170        180 
CIAANINKTL TKIRSIKEPV ALLQEVYRNS VTDLSPTDII TYIEILAESS SLLGYKNNTI 

       190        200        210        220        230        240 
SAKDTLSNST LTEFVKTVNN FVQRDTFVVW DKLSVNHRRT HLTKLMHTVE QATLRISQSF 

       250        260        270        280        290        300 
QKTTEFDTNS TDIALKVFFF DSYNMKHIHP HMNMDGDYIN IFPKRKAAYD SNGNVAVAFV 

       310        320        330        340        350        360 
YYKSIGPLLS SSDNFLLKPQ NYDNSEEEER VISSVISVSM SSNPPTLYEL EKITFTLSHR 

       370        380        390        400        410        420 
KVTDRYRSLC AFWNYSPDTM NGSWSSEGCE LTYSNETHTS CRCNHLTHFA ILMSSGPSIG 

       430        440        450        460        470        480 
IKDYNILTRI TQLGIIISLI CLAICIFTFW FFSEIQSTRT TIHKNLCCSL FLAELVFLVG 

       490        500        510        520        530        540 
INTNTNKLFC SIIAGLLHYF FLAAFAWMCI EGIHLYLIVV GVIYNKGFLH KNFYIFGYLS 

       550        560        570        580        590        600 
PAVVVGFSAA LGYRYYGTTK VCWLSTENNF IWSFIGPACL IILVNLLAFG VIIYKVFRHT 

       610        620        630        640        650        660 
AGLKPEVSCF ENIRSCARGA LALLFLLGTT WIFGVLHVVH ASVVTAYLFT VSNAFQGMFI 

       670        680        690 
FLFLCVLSRK IQEEYYRLFK NVPCCFGCLR 

« Hide

References

« Hide 'large scale' references
[1]"Probable G-protein coupled receptor."
Hirose M., Urakawa I., Yamano S., Okazaki H.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-620.
Tissue: Bone marrow.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-300.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-300.
Tissue: Pancreas.
[6]"ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart."
Nechiporuk T., Urness L.D., Keating M.T.
J. Biol. Chem. 276:4150-4157(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 67-690, VARIANT LEU-300.
[7]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-249.
Tissue: Plasma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB032017 mRNA. Translation: BAD83584.1.
AY358360 mRNA. Translation: AAQ88726.1.
AL596269, AC098651, AC099674 Genomic DNA. Translation: CAI13205.1.
CH471059 Genomic DNA. Translation: EAX06345.1.
BC025721 mRNA. Translation: AAH25721.1. Different initiation.
AF192403 mRNA. Translation: AAG33021.1. Different initiation.
RefSeqNP_071442.2. NM_022159.3.
UniGeneHs.132314.

3D structure databases

ProteinModelPortalQ9HBW9.
SMRQ9HBW9. Positions 20-406, 453-674.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122076. 1 interaction.
IntActQ9HBW9. 1 interaction.
STRING9606.ENSP00000359778.

Protein family/group databases

MEROPSS63.016.
TCDB9.A.14.6.3. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

PTM databases

PhosphoSiteQ9HBW9.

Polymorphism databases

DMDM212276505.

Proteomic databases

PaxDbQ9HBW9.
PRIDEQ9HBW9.

Protocols and materials databases

DNASU64123.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370742; ENSP00000359778; ENSG00000162618.
GeneID64123.
KEGGhsa:64123.
UCSCuc001diq.4. human.

Organism-specific databases

CTD64123.
GeneCardsGC01M079355.
H-InvDBHIX0000724.
HGNCHGNC:20822. ELTD1.
HPAHPA025229.
neXtProtNX_Q9HBW9.
PharmGKBPA134946418.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG276724.
HOGENOMHOG000112361.
HOVERGENHBG101117.
InParanoidQ9HBW9.
KOK04595.
OMAHLTKLMH.
OrthoDBEOG76DTRK.
PhylomeDBQ9HBW9.
TreeFamTF316380.

Gene expression databases

ArrayExpressQ9HBW9.
BgeeQ9HBW9.
CleanExHS_ELTD1.
GenevestigatorQ9HBW9.

Family and domain databases

Gene3D2.40.155.10. 1 hit.
InterProIPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP_like.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF07645. EGF_CA. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
SMARTSM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view]
PROSITEPS00010. ASX_HYDROXYL. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiELTD1.
GenomeRNAi64123.
NextBio66004.
PROQ9HBW9.

Entry information

Entry nameELTD1_HUMAN
AccessionPrimary (citable) accession number: Q9HBW9
Secondary accession number(s): B1AR71, Q5KU34
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 4, 2008
Last modified: April 16, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries