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Protein

Leucine-rich repeat-containing protein 4

Gene

LRRC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128594-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 4
Alternative name(s):
Brain tumor-associated protein BAG
Nasopharyngeal carcinoma-associated gene 14 protein
Netrin-G2 ligand
Short name:
NGL-2
Gene namesi
Name:LRRC4
Synonyms:BAG
ORF Names:NAG14, UNQ554/PRO1111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:15586. LRRC4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 527ExtracellularSequence analysisAdd BLAST489
Transmembranei528 – 548HelicalSequence analysisAdd BLAST21
Topological domaini549 – 653CytoplasmicSequence analysisAdd BLAST105

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi64101.
OpenTargetsiENSG00000128594.
PharmGKBiPA30463.

Polymorphism and mutation databases

BioMutaiLRRC4.
DMDMi51701696.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000001483339 – 653Leucine-rich repeat-containing protein 4Add BLAST615

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 52PROSITE-ProRule annotation1 Publication
Disulfide bondi50 ↔ 61PROSITE-ProRule annotation1 Publication
Glycosylationi277N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi304 ↔ 329PROSITE-ProRule annotation1 Publication
Disulfide bondi306 ↔ 350PROSITE-ProRule annotation1 Publication
Glycosylationi322N-linked (GlcNAc...)Sequence analysis1
Glycosylationi363N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi374 ↔ 424PROSITE-ProRule annotation1 Publication
Glycosylationi388N-linked (GlcNAc...)Sequence analysis1
Glycosylationi410N-linked (GlcNAc...)Sequence analysis1
Glycosylationi434N-linked (GlcNAc...)Sequence analysis1
Glycosylationi440N-linked (GlcNAc...)Sequence analysis1
Glycosylationi447N-linked (GlcNAc...)Sequence analysis1
Glycosylationi450N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9HBW1.
PeptideAtlasiQ9HBW1.
PRIDEiQ9HBW1.

PTM databases

iPTMnetiQ9HBW1.
PhosphoSitePlusiQ9HBW1.

Expressioni

Tissue specificityi

Specifically expressed in brain.1 Publication

Gene expression databases

BgeeiENSG00000128594.
CleanExiHS_LRRC4.
ExpressionAtlasiQ9HBW1. baseline and differential.
GenevisibleiQ9HBW1. HS.

Organism-specific databases

HPAiHPA051100.

Interactioni

Subunit structurei

Interacts with DLG4 (By similarity). Interacts (via LRR repeats) with NTNG2. Forms a complex with DLG4 and with NMDA receptors.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NTNG1Q9Y2I22EBI-7444327,EBI-7444396
NTNG2Q96CW94EBI-7444327,EBI-750795

Protein-protein interaction databases

BioGridi122061. 11 interactors.
IntActiQ9HBW1. 3 interactors.
MINTiMINT-6489320.
STRINGi9606.ENSP00000249363.

Structurei

Secondary structure

1653
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi50 – 52Combined sources3
Beta strandi54 – 56Combined sources3
Beta strandi58 – 60Combined sources3
Beta strandi78 – 81Combined sources4
Turni92 – 97Combined sources6
Beta strandi103 – 105Combined sources3
Turni116 – 121Combined sources6
Beta strandi127 – 129Combined sources3
Turni140 – 142Combined sources3
Beta strandi143 – 145Combined sources3
Beta strandi151 – 153Combined sources3
Turni164 – 169Combined sources6
Beta strandi175 – 177Combined sources3
Turni189 – 194Combined sources6
Beta strandi200 – 202Combined sources3
Beta strandi222 – 224Combined sources3
Beta strandi231 – 233Combined sources3
Helixi235 – 238Combined sources4
Beta strandi246 – 248Combined sources3
Turni259 – 264Combined sources6
Beta strandi270 – 272Combined sources3
Beta strandi294 – 296Combined sources3
Turni306 – 308Combined sources3
Helixi309 – 318Combined sources10
Beta strandi328 – 332Combined sources5
Turni333 – 337Combined sources5
Helixi345 – 347Combined sources3
Beta strandi362 – 365Combined sources4
Beta strandi370 – 372Combined sources3
Beta strandi380 – 385Combined sources6
Turni387 – 389Combined sources3
Beta strandi390 – 393Combined sources4
Beta strandi399 – 403Combined sources5
Beta strandi405 – 407Combined sources3
Beta strandi409 – 413Combined sources5
Turni416 – 418Combined sources3
Beta strandi420 – 427Combined sources8
Beta strandi432 – 440Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DL9NMR-A353-442[»]
3ZYIX-ray2.60A1-444[»]
ProteinModelPortaliQ9HBW1.
SMRiQ9HBW1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HBW1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 75LRRNTAdd BLAST37
Repeati76 – 97LRR 1Add BLAST22
Repeati100 – 121LRR 2Add BLAST22
Repeati124 – 145LRR 3Add BLAST22
Repeati148 – 169LRR 4Add BLAST22
Repeati172 – 194LRR 5Add BLAST23
Repeati197 – 218LRR 6Add BLAST22
Repeati219 – 240LRR 7Add BLAST22
Repeati243 – 264LRR 8Add BLAST22
Repeati267 – 288LRR 9Add BLAST22
Domaini300 – 352LRRCTAdd BLAST53
Domaini353 – 442Ig-likeAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi455 – 526Thr-richAdd BLAST72

Domaini

The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4.By similarity

Sequence similaritiesi

Contains 9 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000252924.
HOVERGENiHBG052359.
InParanoidiQ9HBW1.
KOiK16351.
OMAiSVQPTWN.
OrthoDBiEOG091G037N.
PhylomeDBiQ9HBW1.
TreeFamiTF324303.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026882. Lrrc4.
IPR000372. LRRNT.
[Graphical view]
PANTHERiPTHR24369:SF9. PTHR24369:SF9. 2 hits.
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HBW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLWQVTVH HHTWNAILLP FVYLTAQVWI LCAAIAAAAS AGPQNCPSVC
60 70 80 90 100
SCSNQFSKVV CTRRGLSEVP QGIPSNTRYL NLMENNIQMI QADTFRHLHH
110 120 130 140 150
LEVLQLGRNS IRQIEVGAFN GLASLNTLEL FDNWLTVIPS GAFEYLSKLR
160 170 180 190 200
ELWLRNNPIE SIPSYAFNRV PSLMRLDLGE LKKLEYISEG AFEGLFNLKY
210 220 230 240 250
LNLGMCNIKD MPNLTPLVGL EELEMSGNHF PEIRPGSFHG LSSLKKLWVM
260 270 280 290 300
NSQVSLIERN AFDGLASLVE LNLAHNNLSS LPHDLFTPLR YLVELHLHHN
310 320 330 340 350
PWNCDCDILW LAWWLREYIP TNSTCCGRCH APMHMRGRYL VEVDQASFQC
360 370 380 390 400
SAPFIMDAPR DLNISEGRMA ELKCRTPPMS SVKWLLPNGT VLSHASRHPR
410 420 430 440 450
ISVLNDGTLN FSHVLLSDTG VYTCMVTNVA GNSNASAYLN VSTAELNTSN
460 470 480 490 500
YSFFTTVTVE TTEISPEDTT RKYKPVPTTS TGYQPAYTTS TTVLIQTTRV
510 520 530 540 550
PKQVAVPATD TTDKMQTSLD EVMKTTKIII GCFVAVTLLA AAMLIVFYKL
560 570 580 590 600
RKRHQQRSTV TAARTVEIIQ VDEDIPAATS AAATAAPSGV SGEGAVVLPT
610 620 630 640 650
IHDHINYNTY KPAHGAHWTE NSLGNSLHPT VTTISEPYII QTHTKDKVQE

TQI
Length:653
Mass (Da):72,717
Last modified:October 1, 2001 - v2
Checksum:i38159C81F6850E37
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4L → S in BAD18737 (PubMed:14702039).Curated1
Sequence conflicti253 – 257QVSLI → H in CAC82651 (Ref. 2) Curated5
Sequence conflicti300N → D in BAD18737 (PubMed:14702039).Curated1
Sequence conflicti315L → F in BAD18737 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035519579T → A in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196976 mRNA. Translation: AAG28019.2.
AJ297858 mRNA. Translation: CAC82651.1.
AY358307 mRNA. Translation: AAQ88674.1.
AK172751 mRNA. Translation: BAD18737.1.
AK314047 mRNA. Translation: BAG36756.1.
CH236947 Genomic DNA. Translation: EAL24316.1.
BC111561 mRNA. Translation: AAI11562.1.
BC111745 mRNA. Translation: AAI11746.1.
CCDSiCCDS5799.1.
RefSeqiNP_071426.1. NM_022143.4.
XP_011514763.1. XM_011516461.2.
XP_016867994.1. XM_017012505.1.
UniGeneiHs.655003.

Genome annotation databases

EnsembliENST00000249363; ENSP00000249363; ENSG00000128594.
GeneIDi64101.
KEGGihsa:64101.
UCSCiuc003vmk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196976 mRNA. Translation: AAG28019.2.
AJ297858 mRNA. Translation: CAC82651.1.
AY358307 mRNA. Translation: AAQ88674.1.
AK172751 mRNA. Translation: BAD18737.1.
AK314047 mRNA. Translation: BAG36756.1.
CH236947 Genomic DNA. Translation: EAL24316.1.
BC111561 mRNA. Translation: AAI11562.1.
BC111745 mRNA. Translation: AAI11746.1.
CCDSiCCDS5799.1.
RefSeqiNP_071426.1. NM_022143.4.
XP_011514763.1. XM_011516461.2.
XP_016867994.1. XM_017012505.1.
UniGeneiHs.655003.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DL9NMR-A353-442[»]
3ZYIX-ray2.60A1-444[»]
ProteinModelPortaliQ9HBW1.
SMRiQ9HBW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122061. 11 interactors.
IntActiQ9HBW1. 3 interactors.
MINTiMINT-6489320.
STRINGi9606.ENSP00000249363.

PTM databases

iPTMnetiQ9HBW1.
PhosphoSitePlusiQ9HBW1.

Polymorphism and mutation databases

BioMutaiLRRC4.
DMDMi51701696.

Proteomic databases

PaxDbiQ9HBW1.
PeptideAtlasiQ9HBW1.
PRIDEiQ9HBW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249363; ENSP00000249363; ENSG00000128594.
GeneIDi64101.
KEGGihsa:64101.
UCSCiuc003vmk.4. human.

Organism-specific databases

CTDi64101.
DisGeNETi64101.
GeneCardsiLRRC4.
HGNCiHGNC:15586. LRRC4.
HPAiHPA051100.
MIMi610486. gene.
neXtProtiNX_Q9HBW1.
OpenTargetsiENSG00000128594.
PharmGKBiPA30463.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118831.
HOGENOMiHOG000252924.
HOVERGENiHBG052359.
InParanoidiQ9HBW1.
KOiK16351.
OMAiSVQPTWN.
OrthoDBiEOG091G037N.
PhylomeDBiQ9HBW1.
TreeFamiTF324303.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128594-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9HBW1.
GeneWikiiLRRC4.
GenomeRNAii64101.
PROiQ9HBW1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128594.
CleanExiHS_LRRC4.
ExpressionAtlasiQ9HBW1. baseline and differential.
GenevisibleiQ9HBW1. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR026882. Lrrc4.
IPR000372. LRRNT.
[Graphical view]
PANTHERiPTHR24369:SF9. PTHR24369:SF9. 2 hits.
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRRC4_HUMAN
AccessioniPrimary (citable) accession number: Q9HBW1
Secondary accession number(s): A4D0Y9
, Q14DU9, Q6ZMI8, Q96A85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.