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Protein

Lysophosphatidic acid receptor 2

Gene

LPAR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.2 Publications

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • lipid binding Source: ProtInc
  • lysophosphatidic acid receptor activity Source: InterPro

GO - Biological processi

  • activation of phospholipase C activity Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.
SIGNORiQ9HBW0.

Protein family/group databases

TCDBi9.A.14.2.5. the g-protein-coupled receptor (gpcr) family.

Chemistry

SwissLipidsiSLP:000001569.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 2
Short name:
LPA receptor 2
Short name:
LPA-2
Alternative name(s):
Lysophosphatidic acid receptor Edg-4
Gene namesi
Name:LPAR2
Synonyms:EDG4, LPA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3168. LPAR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence analysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini55 – 6915CytoplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini91 – 10313ExtracellularSequence analysisAdd
BLAST
Transmembranei104 – 12623Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini127 – 14620CytoplasmicSequence analysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini168 – 18821ExtracellularSequence analysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini210 – 24233CytoplasmicSequence analysisAdd
BLAST
Transmembranei243 – 26321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini264 – 27916ExtracellularSequence analysisAdd
BLAST
Transmembranei280 – 29718Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini298 – 35154CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi348 – 3481D → A: Abolishes interaction with MAGI3. 1 Publication
Mutagenesisi349 – 3491S → A: Abolishes interaction with MAGI3. 1 Publication
Mutagenesisi350 – 3501T → A: Does not affect interaction with MAGI3. 1 Publication
Mutagenesisi351 – 3511L → A: Abolishes interaction with MAGI3. 1 Publication

Organism-specific databases

PharmGKBiPA162394202.

Chemistry

ChEMBLiCHEMBL3724.
GuidetoPHARMACOLOGYi273.

Polymorphism and mutation databases

BioMutaiLPAR2.
DMDMi26393399.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Lysophosphatidic acid receptor 2PRO_0000069424Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Lipidationi311 – 3111S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

EPDiQ9HBW0.
MaxQBiQ9HBW0.
PaxDbiQ9HBW0.
PeptideAtlasiQ9HBW0.
PRIDEiQ9HBW0.

PTM databases

iPTMnetiQ9HBW0.
PhosphoSiteiQ9HBW0.

Expressioni

Tissue specificityi

Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.

Gene expression databases

BgeeiENSG00000064547.
CleanExiHS_LPAR2.
ExpressionAtlasiQ9HBW0. baseline and differential.
GenevisibleiQ9HBW0. HS.

Organism-specific databases

HPAiHPA019616.

Interactioni

Subunit structurei

Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3. Interacts with RALA and ADRBK1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CFTRP135694EBI-765995,EBI-349854
SLC9A3R2Q155992EBI-765995,EBI-1149760

Protein-protein interaction databases

BioGridi114611. 7 interactions.
IntActiQ9HBW0. 4 interactions.
STRINGi9606.ENSP00000384665.

Chemistry

BindingDBiQ9HBW0.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4P0CX-ray1.34A347-351[»]
ProteinModelPortaliQ9HBW0.
SMRiQ9HBW0. Positions 6-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi348 – 3514PDZ-binding

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9HBW0.
KOiK04291.
OMAiVVYSCRD.
OrthoDBiEOG091G0DD4.
PhylomeDBiQ9HBW0.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR004066. LPA_rcpt_EDG4.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01528. EDG4RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HBW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIMGQCYYN ETIGFFYNNS GKELSSHWRP KDVVVVALGL TVSVLVLLTN
60 70 80 90 100
LLVIAAIASN RRFHQPIYYL LGNLAAADLF AGVAYLFLMF HTGPRTARLS
110 120 130 140 150
LEGWFLRQGL LDTSLTASVA TLLAIAVERH RSVMAVQLHS RLPRGRVVML
160 170 180 190 200
IVGVWVAALG LGLLPAHSWH CLCALDRCSR MAPLLSRSYL AVWALSSLLV
210 220 230 240 250
FLLMVAVYTR IFFYVRRRVQ RMAEHVSCHP RYRETTLSLV KTVVIILGAF
260 270 280 290 300
VVCWTPGQVV LLLDGLGCES CNVLAVEKYF LLLAEANSLV NAAVYSCRDA
310 320 330 340 350
EMRRTFRRLL CCACLRQSTR ESVHYTSSAQ GGASTRIMLP ENGHPLMDST

L
Length:351
Mass (Da):39,084
Last modified:December 6, 2002 - v2
Checksum:iDE225B0B3E9351B8
GO

Sequence cautioni

The sequence AAC27728 differs from that shown. Reason: Frameshift at position 348. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 2211R → S in AAG28521 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011466 mRNA. Translation: AAC27728.1. Frameshift.
AF233092 mRNA. Translation: AAF43409.1.
AF197929 mRNA. Translation: AAG28521.1.
AY322548 mRNA. Translation: AAP84361.1.
AC002306 Genomic DNA. Translation: AAB61528.1.
BC025695 mRNA. Translation: AAH25695.1.
CCDSiCCDS12407.1.
RefSeqiNP_004711.2. NM_004720.5.
XP_011526723.1. XM_011528421.2.
UniGeneiHs.122575.

Genome annotation databases

EnsembliENST00000407877; ENSP00000384665; ENSG00000064547.
ENST00000542587; ENSP00000443256; ENSG00000064547.
ENST00000586703; ENSP00000465280; ENSG00000064547.
GeneIDi9170.
KEGGihsa:9170.
UCSCiuc002nna.6. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011466 mRNA. Translation: AAC27728.1. Frameshift.
AF233092 mRNA. Translation: AAF43409.1.
AF197929 mRNA. Translation: AAG28521.1.
AY322548 mRNA. Translation: AAP84361.1.
AC002306 Genomic DNA. Translation: AAB61528.1.
BC025695 mRNA. Translation: AAH25695.1.
CCDSiCCDS12407.1.
RefSeqiNP_004711.2. NM_004720.5.
XP_011526723.1. XM_011528421.2.
UniGeneiHs.122575.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4P0CX-ray1.34A347-351[»]
ProteinModelPortaliQ9HBW0.
SMRiQ9HBW0. Positions 6-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114611. 7 interactions.
IntActiQ9HBW0. 4 interactions.
STRINGi9606.ENSP00000384665.

Chemistry

BindingDBiQ9HBW0.
ChEMBLiCHEMBL3724.
GuidetoPHARMACOLOGYi273.
SwissLipidsiSLP:000001569.

Protein family/group databases

TCDBi9.A.14.2.5. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiQ9HBW0.
PhosphoSiteiQ9HBW0.

Polymorphism and mutation databases

BioMutaiLPAR2.
DMDMi26393399.

Proteomic databases

EPDiQ9HBW0.
MaxQBiQ9HBW0.
PaxDbiQ9HBW0.
PeptideAtlasiQ9HBW0.
PRIDEiQ9HBW0.

Protocols and materials databases

DNASUi9170.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000407877; ENSP00000384665; ENSG00000064547.
ENST00000542587; ENSP00000443256; ENSG00000064547.
ENST00000586703; ENSP00000465280; ENSG00000064547.
GeneIDi9170.
KEGGihsa:9170.
UCSCiuc002nna.6. human.

Organism-specific databases

CTDi9170.
GeneCardsiLPAR2.
HGNCiHGNC:3168. LPAR2.
HPAiHPA019616.
MIMi605110. gene.
neXtProtiNX_Q9HBW0.
PharmGKBiPA162394202.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9HBW0.
KOiK04291.
OMAiVVYSCRD.
OrthoDBiEOG091G0DD4.
PhylomeDBiQ9HBW0.

Enzyme and pathway databases

ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.
SIGNORiQ9HBW0.

Miscellaneous databases

ChiTaRSiLPAR2. human.
GeneWikiiLPAR2.
GenomeRNAii9170.
PROiQ9HBW0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064547.
CleanExiHS_LPAR2.
ExpressionAtlasiQ9HBW0. baseline and differential.
GenevisibleiQ9HBW0. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR004066. LPA_rcpt_EDG4.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01528. EDG4RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLPAR2_HUMAN
AccessioniPrimary (citable) accession number: Q9HBW0
Secondary accession number(s): O00543, O43431
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: September 7, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

PubMed:9525886 cDNA clone has a guanine nucleotide deletion that causes a frameshift near its C-terminal coding region. This likely reflects a somatic mutation in the ovary tumor cells from which the cDNA was isolated and may have altered the function of the encoded receptor, and contributed to transformation of the original ovary cells that formed a tumor.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.