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Protein

Sperm acrosome membrane-associated protein 1

Gene

SPACA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in sperm-egg fusion.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm acrosome membrane-associated protein 1
Alternative name(s):
Sperm acrosomal membrane-associated protein 32
Gene namesi
Name:SPACA1
Synonyms:SAMP32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14967. SPACA1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 221192ExtracellularSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Topological domaini243 – 29452CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37943.

Polymorphism and mutation databases

BioMutaiSPACA1.
DMDMi74752784.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 294265Sperm acrosome membrane-associated protein 1PRO_0000248152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence analysis
Modified residuei256 – 2561Phosphoserine1 Publication
Modified residuei290 – 2901PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9HBV2.
PeptideAtlasiQ9HBV2.
PRIDEiQ9HBV2.

PTM databases

iPTMnetiQ9HBV2.
PhosphoSiteiQ9HBV2.

Expressioni

Tissue specificityi

Testis specific. At the equatorial segment and the inner acrosomal membrane of capacitated sperm.1 Publication

Gene expression databases

BgeeiENSG00000118434.
CleanExiHS_SPACA1.
GenevisibleiQ9HBV2. HS.

Organism-specific databases

HPAiHPA026744.
HPA043297.

Interactioni

Protein-protein interaction databases

BioGridi123591. 65 interactions.
STRINGi9606.ENSP00000237201.

Structurei

3D structure databases

ProteinModelPortaliQ9HBV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFV6. Eukaryota.
ENOG410YPX9. LUCA.
GeneTreeiENSGT00390000004211.
HOGENOMiHOG000049221.
HOVERGENiHBG080320.
InParanoidiQ9HBV2.
OMAiWGAKAST.
OrthoDBiEOG091G0M9J.
PhylomeDBiQ9HBV2.
TreeFamiTF336918.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HBV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPRGTGCSA GLLMTVGWLL LAGLQSARGT NVTAAVQDAG LAHEGEGEEE
60 70 80 90 100
TENNDSETAE NYAPPETEDV SNRNVVKEVE FGMCTVTCGI GVREVILTNG
110 120 130 140 150
CPGGESKCVV RVEECRGPTD CGWGKPISES LESVRLACIH TSPLNRFKYM
160 170 180 190 200
WKLLRQDQQS IILVNDSAIL EVRKESHPLA FECDTLDNNE IVATIKFTVY
210 220 230 240 250
TSSELQMRRS SLPATDAALI FVLTIGVIIC VFIIFLLIFI IINWAAVKAF
260 270 280 290
WGAKASTPEV QSEQSSVRYK DSTSLDQLPT EMPGEDDALS EWNE
Length:294
Mass (Da):32,143
Last modified:March 1, 2001 - v1
Checksum:i60DB3107E1B03D12
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti237 – 2371L → S.
Corresponds to variant rs2276089 [ dbSNP | Ensembl ].
VAR_027258

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203447 mRNA. Translation: AAG31422.1.
AL136096 Genomic DNA. Translation: CAI19915.1.
BC029488 mRNA. Translation: AAH29488.1.
CCDSiCCDS5014.1.
RefSeqiNP_112222.1. NM_030960.2.
UniGeneiHs.161241.

Genome annotation databases

EnsembliENST00000237201; ENSP00000237201; ENSG00000118434.
GeneIDi81833.
KEGGihsa:81833.
UCSCiuc003pmn.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203447 mRNA. Translation: AAG31422.1.
AL136096 Genomic DNA. Translation: CAI19915.1.
BC029488 mRNA. Translation: AAH29488.1.
CCDSiCCDS5014.1.
RefSeqiNP_112222.1. NM_030960.2.
UniGeneiHs.161241.

3D structure databases

ProteinModelPortaliQ9HBV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123591. 65 interactions.
STRINGi9606.ENSP00000237201.

PTM databases

iPTMnetiQ9HBV2.
PhosphoSiteiQ9HBV2.

Polymorphism and mutation databases

BioMutaiSPACA1.
DMDMi74752784.

Proteomic databases

PaxDbiQ9HBV2.
PeptideAtlasiQ9HBV2.
PRIDEiQ9HBV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237201; ENSP00000237201; ENSG00000118434.
GeneIDi81833.
KEGGihsa:81833.
UCSCiuc003pmn.3. human.

Organism-specific databases

CTDi81833.
GeneCardsiSPACA1.
HGNCiHGNC:14967. SPACA1.
HPAiHPA026744.
HPA043297.
MIMi612739. gene.
neXtProtiNX_Q9HBV2.
PharmGKBiPA37943.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFV6. Eukaryota.
ENOG410YPX9. LUCA.
GeneTreeiENSGT00390000004211.
HOGENOMiHOG000049221.
HOVERGENiHBG080320.
InParanoidiQ9HBV2.
OMAiWGAKAST.
OrthoDBiEOG091G0M9J.
PhylomeDBiQ9HBV2.
TreeFamiTF336918.

Miscellaneous databases

GenomeRNAii81833.
PROiQ9HBV2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118434.
CleanExiHS_SPACA1.
GenevisibleiQ9HBV2. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSACA1_HUMAN
AccessioniPrimary (citable) accession number: Q9HBV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.