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Protein

Popeye domain-containing protein 3

Gene

POPDC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Popeye domain-containing protein 3
Short name:
Popeye protein 3
Gene namesi
Name:POPDC3
Synonyms:POP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17649. POPDC3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 44HelicalSequence analysisAdd BLAST18
Transmembranei48 – 70HelicalSequence analysisAdd BLAST23
Transmembranei77 – 99HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64208.
OpenTargetsiENSG00000132429.
PharmGKBiPA134935151.

Polymorphism and mutation databases

BioMutaiPOPDC3.
DMDMi38258245.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000467951 – 291Popeye domain-containing protein 3Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9HBV1.
PRIDEiQ9HBV1.

PTM databases

PhosphoSitePlusiQ9HBV1.

Expressioni

Tissue specificityi

Expressed predominantly in skeletal muscle and detected in heart.1 Publication

Gene expression databases

BgeeiENSG00000132429.
CleanExiHS_POPDC3.
ExpressionAtlasiQ9HBV1. baseline and differential.
GenevisibleiQ9HBV1. HS.

Organism-specific databases

HPAiHPA012514.

Interactioni

Protein-protein interaction databases

BioGridi122102. 1 interactor.
STRINGi9606.ENSP00000254765.

Structurei

3D structure databases

ProteinModelPortaliQ9HBV1.
SMRiQ9HBV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the popeye family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGHK. Eukaryota.
ENOG410ZTIT. LUCA.
GeneTreeiENSGT00390000002563.
HOGENOMiHOG000050233.
HOVERGENiHBG053639.
InParanoidiQ9HBV1.
OMAiHYIYPFQ.
OrthoDBiEOG091G0CVO.
PhylomeDBiQ9HBV1.
TreeFamiTF326644.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR006916. Popeye_prot.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR12101. PTHR12101. 1 hit.
PfamiPF04831. Popeye. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HBV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERNSSLWKN LIDEHPVCTT WKQEAEGAIY HLASILFVVG FMGGSGFFGL
60 70 80 90 100
LYVFSLLGLG FLCSAVWAWV DVCAADIFSW NFVLFVICFM QFVHIAYQVR
110 120 130 140 150
SITFAREFQV LYSSLFQPLG ISLPVFRTIA LSSEVVTLEK EHCYAMQGKT
160 170 180 190 200
SIDKLSLLVS GRIRVTVDGE FLHYIFPLQF LDSPEWDSLR PTEEGIFQVT
210 220 230 240 250
LTAETDCRYV SWRRKKLYLL FAQHRYISRL FSVLIGSDIA DKLYALNDRV
260 270 280 290
YIGKRYHYDI RLPNFYQMST PEIRRSPLTQ HFQNSRRYCD K
Length:291
Mass (Da):33,870
Last modified:October 31, 2003 - v2
Checksum:i49A3EF5216B2DDC2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176F → S in AAG23404 (PubMed:10882522).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053602106R → Q.Corresponds to variant rs11961225dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204171 mRNA. Translation: AAG23404.1.
AK314101 mRNA. Translation: BAG36795.1.
AL359709, AL356775 Genomic DNA. Translation: CAI17218.1.
AL356775, AL359709 Genomic DNA. Translation: CAI13615.1.
CH471051 Genomic DNA. Translation: EAW48427.1.
BC022323 mRNA. Translation: AAH22323.1.
CCDSiCCDS5052.1.
RefSeqiNP_071756.2. NM_022361.4.
XP_011534369.1. XM_011536067.2.
XP_016866683.1. XM_017011194.1.
XP_016866684.1. XM_017011195.1.
UniGeneiHs.458336.

Genome annotation databases

EnsembliENST00000254765; ENSP00000254765; ENSG00000132429.
GeneIDi64208.
KEGGihsa:64208.
UCSCiuc003prb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204171 mRNA. Translation: AAG23404.1.
AK314101 mRNA. Translation: BAG36795.1.
AL359709, AL356775 Genomic DNA. Translation: CAI17218.1.
AL356775, AL359709 Genomic DNA. Translation: CAI13615.1.
CH471051 Genomic DNA. Translation: EAW48427.1.
BC022323 mRNA. Translation: AAH22323.1.
CCDSiCCDS5052.1.
RefSeqiNP_071756.2. NM_022361.4.
XP_011534369.1. XM_011536067.2.
XP_016866683.1. XM_017011194.1.
XP_016866684.1. XM_017011195.1.
UniGeneiHs.458336.

3D structure databases

ProteinModelPortaliQ9HBV1.
SMRiQ9HBV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122102. 1 interactor.
STRINGi9606.ENSP00000254765.

PTM databases

PhosphoSitePlusiQ9HBV1.

Polymorphism and mutation databases

BioMutaiPOPDC3.
DMDMi38258245.

Proteomic databases

PaxDbiQ9HBV1.
PRIDEiQ9HBV1.

Protocols and materials databases

DNASUi64208.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254765; ENSP00000254765; ENSG00000132429.
GeneIDi64208.
KEGGihsa:64208.
UCSCiuc003prb.4. human.

Organism-specific databases

CTDi64208.
DisGeNETi64208.
GeneCardsiPOPDC3.
HGNCiHGNC:17649. POPDC3.
HPAiHPA012514.
MIMi605824. gene.
neXtProtiNX_Q9HBV1.
OpenTargetsiENSG00000132429.
PharmGKBiPA134935151.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGHK. Eukaryota.
ENOG410ZTIT. LUCA.
GeneTreeiENSGT00390000002563.
HOGENOMiHOG000050233.
HOVERGENiHBG053639.
InParanoidiQ9HBV1.
OMAiHYIYPFQ.
OrthoDBiEOG091G0CVO.
PhylomeDBiQ9HBV1.
TreeFamiTF326644.

Miscellaneous databases

GeneWikiiPOPDC3.
GenomeRNAii64208.
PROiQ9HBV1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132429.
CleanExiHS_POPDC3.
ExpressionAtlasiQ9HBV1. baseline and differential.
GenevisibleiQ9HBV1. HS.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR006916. Popeye_prot.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR12101. PTHR12101. 1 hit.
PfamiPF04831. Popeye. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPOPD3_HUMAN
AccessioniPrimary (citable) accession number: Q9HBV1
Secondary accession number(s): B2RA98, Q5T3Y8, Q8TBW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.