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Q9HBU9 (POPD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Popeye domain-containing protein 2

Short name=Popeye protein 2
Gene names
Name:POPDC2
Synonyms:POP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play an important role in heart development. Ref.1

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed predominantly in the heart, and is also detected in the skeletal muscle. Ref.1

Sequence similarities

Belongs to the popeye family.

Sequence caution

The sequence AAH26911.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9HBU9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HBU9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     337-364: ASRIPLQSYSQVISRGQAPLAPTHTPEL → EIDDFPSYFHQFGFSGKVAAGRIP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Popeye domain-containing protein 2
PRO_0000046793

Regions

Transmembrane37 – 5721Helical; Potential
Transmembrane77 – 9721Helical; Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence337 – 36428ASRIP…HTPEL → EIDDFPSYFHQFGFSGKVAA GRIP in isoform 2.
VSP_008743
Natural variant291V → I.
Corresponds to variant rs4688023 [ dbSNP | Ensembl ].
VAR_053601

Experimental info

Sequence conflict3111S → F in AAG23406. Ref.1
Sequence conflict315 – 32814ATTNF…TRARL → RFPPTFPALSYRGQVC Ref.1
Sequence conflict331 – 3333PDS → ASN Ref.1
Sequence conflict3391R → K in AAG23406. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 31, 2003. Version 2.
Checksum: F29AA48CD611BE51

FASTA36440,448
        10         20         30         40         50         60 
MSANSSRVGQ LLLQGSACIR WKQDVEGAVY HLANCLLLLG FMGGSGVYGC FYLFGFLSAG 

        70         80         90        100        110        120 
YLCCVLWGWF SACGLDIVLW SFLLAVVCLL QLAHLVYRLR EDTLPEEFDL LYKTLCLPLQ 

       130        140        150        160        170        180 
VPLQTYKEIV HCCEEQVLTL ATEQTYAVEG ETPINRLSLL LSGRVRVSQD GQFLHYIFPY 

       190        200        210        220        230        240 
QFMDSPEWES LQPSEEGVFQ VTLTAETSCS YISWPRKSLH LLLTKERYIS CLFSALLGYD 

       250        260        270        280        290        300 
ISEKLYTLND KLFAKFGLRF DIRLPSLYHV LGPTAADAGP ESEKGDEEVC EPAVSPPQAT 

       310        320        330        340        350        360 
PTSLQQTPPC STPPATTNFP APPTRARLSR PDSGILASRI PLQSYSQVIS RGQAPLAPTH 


TPEL 

« Hide

Isoform 2 [UniParc].

Checksum: 497BDAC0D50C6EE9
Show »

FASTA36040,115

References

« Hide 'large scale' references
[1]"Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart."
Andree B., Hillemann T., Kessler-Icekson G., Schmitt-John T., Jockusch H., Arnold H.-H., Brand T.
Dev. Biol. 223:371-382(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), POSSIBLE FUNCTION, TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Colon, Kidney, Stomach and Urinary bladder.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF204173 mRNA. Translation: AAG23406.1.
BC026911 mRNA. Translation: AAH26911.1. Different initiation.
BC044929 mRNA. Translation: AAH44929.1.
RefSeqNP_071418.2. NM_022135.2.
XP_005247756.1. XM_005247699.1.
UniGeneHs.534383.
Hs.656031.

3D structure databases

ProteinModelPortalQ9HBU9.
SMRQ9HBU9. Positions 125-254.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9HBU9. 1 interaction.
MINTMINT-6544493.
STRING9606.ENSP00000264231.

PTM databases

PhosphoSiteQ9HBU9.

Polymorphism databases

DMDM38258244.

Proteomic databases

PaxDbQ9HBU9.
PRIDEQ9HBU9.

Protocols and materials databases

DNASU64091.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264231; ENSP00000264231; ENSG00000121577. [Q9HBU9-1]
ENST00000468801; ENSP00000420715; ENSG00000121577. [Q9HBU9-2]
ENST00000538678; ENSP00000438271; ENSG00000121577. [Q9HBU9-2]
GeneID64091.
KEGGhsa:64091.
UCSCuc003ecx.1. human. [Q9HBU9-1]
uc010hqw.1. human. [Q9HBU9-2]

Organism-specific databases

CTD64091.
GeneCardsGC03M119355.
HGNCHGNC:17648. POPDC2.
HPAHPA024255.
MIM605823. gene.
neXtProtNX_Q9HBU9.
PharmGKBPA134982197.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG84367.
HOGENOMHOG000050233.
HOVERGENHBG053639.
InParanoidQ9HBU9.
PhylomeDBQ9HBU9.
TreeFamTF326644.

Gene expression databases

ArrayExpressQ9HBU9.
BgeeQ9HBU9.
CleanExHS_POPDC2.
GenevestigatorQ9HBU9.

Family and domain databases

InterProIPR018490. cNMP-bd-like.
IPR006916. Popeye_prot.
[Graphical view]
PANTHERPTHR12101. PTHR12101. 1 hit.
PfamPF04831. Popeye. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
ProtoNetSearch...

Other

GeneWikiPOPDC2.
GenomeRNAi64091.
NextBio65900.
PROQ9HBU9.
SOURCESearch...

Entry information

Entry namePOPD2_HUMAN
AccessionPrimary (citable) accession number: Q9HBU9
Secondary accession number(s): Q86UE7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: March 19, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM