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Protein

Popeye domain-containing protein 2

Gene

POPDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in heart development.

GO - Molecular functioni

  1. cAMP binding Source: Ensembl

GO - Biological processi

  1. regulation of heart rate Source: Ensembl
  2. regulation of membrane potential Source: Ensembl
  3. sinoatrial node cell development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Popeye domain-containing protein 2
Short name:
Popeye protein 2
Gene namesi
Name:POPDC2
Synonyms:POP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:17648. POPDC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982197.

Polymorphism and mutation databases

BioMutaiPOPDC2.
DMDMi38258244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Popeye domain-containing protein 2PRO_0000046793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9HBU9.
PRIDEiQ9HBU9.

PTM databases

PhosphoSiteiQ9HBU9.

Expressioni

Tissue specificityi

Expressed predominantly in the heart, and is also detected in the skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9HBU9.
CleanExiHS_POPDC2.
ExpressionAtlasiQ9HBU9. baseline and differential.
GenevestigatoriQ9HBU9.

Organism-specific databases

HPAiHPA024255.

Interactioni

Protein-protein interaction databases

BioGridi122053. 17 interactions.
IntActiQ9HBU9. 1 interaction.
MINTiMINT-6544493.
STRINGi9606.ENSP00000264231.

Structurei

3D structure databases

ProteinModelPortaliQ9HBU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the popeye family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84367.
GeneTreeiENSGT00390000002563.
HOGENOMiHOG000050233.
HOVERGENiHBG053639.
InParanoidiQ9HBU9.
PhylomeDBiQ9HBU9.
TreeFamiTF326644.

Family and domain databases

InterProiIPR018490. cNMP-bd-like.
IPR006916. Popeye_prot.
[Graphical view]
PANTHERiPTHR12101. PTHR12101. 1 hit.
PfamiPF04831. Popeye. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HBU9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSANSSRVGQ LLLQGSACIR WKQDVEGAVY HLANCLLLLG FMGGSGVYGC
60 70 80 90 100
FYLFGFLSAG YLCCVLWGWF SACGLDIVLW SFLLAVVCLL QLAHLVYRLR
110 120 130 140 150
EDTLPEEFDL LYKTLCLPLQ VPLQTYKEIV HCCEEQVLTL ATEQTYAVEG
160 170 180 190 200
ETPINRLSLL LSGRVRVSQD GQFLHYIFPY QFMDSPEWES LQPSEEGVFQ
210 220 230 240 250
VTLTAETSCS YISWPRKSLH LLLTKERYIS CLFSALLGYD ISEKLYTLND
260 270 280 290 300
KLFAKFGLRF DIRLPSLYHV LGPTAADAGP ESEKGDEEVC EPAVSPPQAT
310 320 330 340 350
PTSLQQTPPC STPPATTNFP APPTRARLSR PDSGILASRI PLQSYSQVIS
360
RGQAPLAPTH TPEL
Length:364
Mass (Da):40,448
Last modified:October 31, 2003 - v2
Checksum:iF29AA48CD611BE51
GO
Isoform 2 (identifier: Q9HBU9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-364: ASRIPLQSYSQVISRGQAPLAPTHTPEL → EIDDFPSYFHQFGFSGKVAAGRIP

Note: No experimental confirmation available.

Show »
Length:360
Mass (Da):40,115
Checksum:i497BDAC0D50C6EE9
GO

Sequence cautioni

The sequence AAH26911.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti311 – 3111S → F in AAG23406 (PubMed:10882522).Curated
Sequence conflicti315 – 32814ATTNF…TRARL → RFPPTFPALSYRGQVC (PubMed:10882522).CuratedAdd
BLAST
Sequence conflicti331 – 3333PDS → ASN (PubMed:10882522).Curated
Sequence conflicti339 – 3391R → K in AAG23406 (PubMed:10882522).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291V → I.
Corresponds to variant rs4688023 [ dbSNP | Ensembl ].
VAR_053601

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei337 – 36428ASRIP…HTPEL → EIDDFPSYFHQFGFSGKVAA GRIP in isoform 2. 1 PublicationVSP_008743Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204173 mRNA. Translation: AAG23406.1.
BC026911 mRNA. Translation: AAH26911.1. Different initiation.
BC044929 mRNA. Translation: AAH44929.1.
CCDSiCCDS2992.1. [Q9HBU9-1]
RefSeqiNP_071418.2. NM_022135.2. [Q9HBU9-1]
XP_005247756.1. XM_005247699.2. [Q9HBU9-2]
UniGeneiHs.534383.
Hs.656031.

Genome annotation databases

EnsembliENST00000264231; ENSP00000264231; ENSG00000121577. [Q9HBU9-1]
ENST00000468801; ENSP00000420715; ENSG00000121577. [Q9HBU9-2]
GeneIDi64091.
KEGGihsa:64091.
UCSCiuc003ecx.1. human. [Q9HBU9-1]
uc010hqw.1. human. [Q9HBU9-2]

Polymorphism and mutation databases

BioMutaiPOPDC2.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204173 mRNA. Translation: AAG23406.1.
BC026911 mRNA. Translation: AAH26911.1. Different initiation.
BC044929 mRNA. Translation: AAH44929.1.
CCDSiCCDS2992.1. [Q9HBU9-1]
RefSeqiNP_071418.2. NM_022135.2. [Q9HBU9-1]
XP_005247756.1. XM_005247699.2. [Q9HBU9-2]
UniGeneiHs.534383.
Hs.656031.

3D structure databases

ProteinModelPortaliQ9HBU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122053. 17 interactions.
IntActiQ9HBU9. 1 interaction.
MINTiMINT-6544493.
STRINGi9606.ENSP00000264231.

PTM databases

PhosphoSiteiQ9HBU9.

Polymorphism and mutation databases

BioMutaiPOPDC2.
DMDMi38258244.

Proteomic databases

PaxDbiQ9HBU9.
PRIDEiQ9HBU9.

Protocols and materials databases

DNASUi64091.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264231; ENSP00000264231; ENSG00000121577. [Q9HBU9-1]
ENST00000468801; ENSP00000420715; ENSG00000121577. [Q9HBU9-2]
GeneIDi64091.
KEGGihsa:64091.
UCSCiuc003ecx.1. human. [Q9HBU9-1]
uc010hqw.1. human. [Q9HBU9-2]

Organism-specific databases

CTDi64091.
GeneCardsiGC03M119355.
HGNCiHGNC:17648. POPDC2.
HPAiHPA024255.
MIMi605823. gene.
neXtProtiNX_Q9HBU9.
PharmGKBiPA134982197.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG84367.
GeneTreeiENSGT00390000002563.
HOGENOMiHOG000050233.
HOVERGENiHBG053639.
InParanoidiQ9HBU9.
PhylomeDBiQ9HBU9.
TreeFamiTF326644.

Miscellaneous databases

GeneWikiiPOPDC2.
GenomeRNAii64091.
NextBioi65900.
PROiQ9HBU9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HBU9.
CleanExiHS_POPDC2.
ExpressionAtlasiQ9HBU9. baseline and differential.
GenevestigatoriQ9HBU9.

Family and domain databases

InterProiIPR018490. cNMP-bd-like.
IPR006916. Popeye_prot.
[Graphical view]
PANTHERiPTHR12101. PTHR12101. 1 hit.
PfamiPF04831. Popeye. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart."
    Andree B., Hillemann T., Kessler-Icekson G., Schmitt-John T., Jockusch H., Arnold H.-H., Brand T.
    Dev. Biol. 223:371-382(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), POSSIBLE FUNCTION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Colon, Kidney, Stomach and Urinary bladder.

Entry informationi

Entry nameiPOPD2_HUMAN
AccessioniPrimary (citable) accession number: Q9HBU9
Secondary accession number(s): Q86UE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: April 29, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.