Q9HBU9 (POPD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Popeye domain-containing protein 2
Short name=Popeye protein 2

Gene names

Name:	POPDC2
Synonyms:	POP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play an important role in heart development. Ref.1
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed predominantly in the heart, and is also detected in the skeletal muscle. Ref.1
Sequence similarities	Belongs to the popeye family.
Sequence caution	The sequence AAH26911.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HBU9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HBU9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     337-364: ASRIPLQSYSQVISRGQAPLAPTHTPEL → EIDDFPSYFHQFGFSGKVAAGRIP

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Popeye domain-containing protein 2		PRO_0000046793
Regions
	Transmembrane	37 – 57	21	Helical; Potential
	Transmembrane	77 – 97	21	Helical; Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	337 – 364	28	ASRIP…HTPEL → EIDDFPSYFHQFGFSGKVAA GRIP in isoform 2.		VSP_008743
	Natural variant	29	1	V → I. Corresponds to variant rs4688023 [ dbSNP | Ensembl ].		VAR_053601
Experimental info
	Sequence conflict	311	1	S → F in AAG23406. Ref.1
	Sequence conflict	315 – 328	14	ATTNF…TRARL → RFPPTFPALSYRGQVC Ref.1
	Sequence conflict	331 – 333	3	PDS → ASN Ref.1
	Sequence conflict	339	1	R → K in AAG23406. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 31, 2003. Version 2. Checksum: F29AA48CD611BE51	FASTA	364	40,448
	10 20 30 40 50 60 MSANSSRVGQ LLLQGSACIR WKQDVEGAVY HLANCLLLLG FMGGSGVYGC FYLFGFLSAG 70 80 90 100 110 120 YLCCVLWGWF SACGLDIVLW SFLLAVVCLL QLAHLVYRLR EDTLPEEFDL LYKTLCLPLQ 130 140 150 160 170 180 VPLQTYKEIV HCCEEQVLTL ATEQTYAVEG ETPINRLSLL LSGRVRVSQD GQFLHYIFPY 190 200 210 220 230 240 QFMDSPEWES LQPSEEGVFQ VTLTAETSCS YISWPRKSLH LLLTKERYIS CLFSALLGYD 250 260 270 280 290 300 ISEKLYTLND KLFAKFGLRF DIRLPSLYHV LGPTAADAGP ESEKGDEEVC EPAVSPPQAT 310 320 330 340 350 360 PTSLQQTPPC STPPATTNFP APPTRARLSR PDSGILASRI PLQSYSQVIS RGQAPLAPTH TPEL
	Isoform 2 [UniParc]. Checksum: 497BDAC0D50C6EE9	FASTA	360	40,115
	10 20 30 40 50 60 MSANSSRVGQ LLLQGSACIR WKQDVEGAVY HLANCLLLLG FMGGSGVYGC FYLFGFLSAG 70 80 90 100 110 120 YLCCVLWGWF SACGLDIVLW SFLLAVVCLL QLAHLVYRLR EDTLPEEFDL LYKTLCLPLQ 130 140 150 160 170 180 VPLQTYKEIV HCCEEQVLTL ATEQTYAVEG ETPINRLSLL LSGRVRVSQD GQFLHYIFPY 190 200 210 220 230 240 QFMDSPEWES LQPSEEGVFQ VTLTAETSCS YISWPRKSLH LLLTKERYIS CLFSALLGYD 250 260 270 280 290 300 ISEKLYTLND KLFAKFGLRF DIRLPSLYHV LGPTAADAGP ESEKGDEEVC EPAVSPPQAT 310 320 330 340 350 360 PTSLQQTPPC STPPATTNFP APPTRARLSR PDSGILEIDD FPSYFHQFGF SGKVAAGRIP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart." Andree B., Hillemann T., Kessler-Icekson G., Schmitt-John T., Jockusch H., Arnold H.-H., Brand T. Dev. Biol. 223:371-382(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), POSSIBLE FUNCTION, TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Colon, Kidney, Stomach and Urinary bladder.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF204173 mRNA. Translation: AAG23406.1. BC026911 mRNA. Translation: AAH26911.1. Different initiation. BC044929 mRNA. Translation: AAH44929.1.
IPI	IPI00328717. IPI00387163.
RefSeq	NP_071418.2. NM_022135.2.
UniGene	Hs.656031.
3D structure databases
ProteinModelPortal	Q9HBU9.
SMR	Q9HBU9. Positions 126-254.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6544493.
PTM databases
PhosphoSite	Q9HBU9.
Polymorphism databases
DMDM	38258244.
Proteomic databases
PaxDb	Q9HBU9.
PRIDE	Q9HBU9.
Protocols and materials databases
DNASU	64091.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264231; ENSP00000264231; ENSG00000121577. ENST00000468801; ENSP00000420715; ENSG00000121577. ENST00000538678; ENSP00000438271; ENSG00000121577.
GeneID	64091.
KEGG	hsa:64091.
UCSC	uc003ecx.1. human. uc010hqw.1. human.
Organism-specific databases
CTD	64091.
GeneCards	GC03M119355.
HGNC	HGNC:17648. POPDC2.
HPA	HPA024255.
MIM	605823. gene.
neXtProt	NX_Q9HBU9.
PharmGKB	PA134982197.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG84367.
HOGENOM	HOG000050233.
HOVERGEN	HBG053639.
InParanoid	Q9HBU9.
PhylomeDB	Q9HBU9.
Gene expression databases
ArrayExpress	Q9HBU9.
Bgee	Q9HBU9.
CleanEx	HS_POPDC2.
Genevestigator	Q9HBU9.
GermOnline	ENSG00000121577. Homo sapiens.
Family and domain databases
InterPro	IPR018490. cNMP-bd-like. IPR006916. Popeye_prot. [Graphical view]
PANTHER	PTHR12101. PTHR12101. 1 hit.
Pfam	PF04831. Popeye. 1 hit. [Graphical view]
SUPFAM	SSF51206. cNMP_binding. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	64091.
NextBio	65900.
SOURCE	Search...

Entry information

Entry name

POPD2_HUMAN

Accession

Primary (citable) accession number: Q9HBU9
Secondary accession number(s): Q86UE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	October 31, 2003
Last modified:	April 3, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.