Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Popeye domain-containing protein 2

Gene

POPDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121577-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Popeye domain-containing protein 2
Short name:
Popeye protein 2
Gene namesi
Name:POPDC2
Synonyms:POP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:17648. POPDC2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • sarcolemma Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121577.
PharmGKBiPA134982197.

Polymorphism and mutation databases

BioMutaiPOPDC2.
DMDMi38258244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000467931 – 364Popeye domain-containing protein 2Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Modified residuei361PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9HBU9.
PeptideAtlasiQ9HBU9.
PRIDEiQ9HBU9.

PTM databases

iPTMnetiQ9HBU9.
PhosphoSitePlusiQ9HBU9.

Expressioni

Tissue specificityi

Expressed predominantly in the heart and in the skeletal muscle.2 Publications

Gene expression databases

BgeeiENSG00000121577.
CleanExiHS_POPDC2.
ExpressionAtlasiQ9HBU9. baseline and differential.
GenevisibleiQ9HBU9. HS.

Organism-specific databases

HPAiHPA024255.

Interactioni

Protein-protein interaction databases

BioGridi122053. 22 interactors.
IntActiQ9HBU9. 1 interactor.
MINTiMINT-6544493.
STRINGi9606.ENSP00000264231.

Structurei

3D structure databases

ProteinModelPortaliQ9HBU9.
SMRiQ9HBU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the popeye family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGHK. Eukaryota.
ENOG410ZTIT. LUCA.
GeneTreeiENSGT00390000002563.
HOGENOMiHOG000050233.
HOVERGENiHBG053639.
InParanoidiQ9HBU9.
PhylomeDBiQ9HBU9.
TreeFamiTF326644.

Family and domain databases

InterProiIPR018490. cNMP-bd-like.
IPR006916. Popeye_prot.
[Graphical view]
PANTHERiPTHR12101. PTHR12101. 1 hit.
PfamiPF04831. Popeye. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HBU9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSANSSRVGQ LLLQGSACIR WKQDVEGAVY HLANCLLLLG FMGGSGVYGC
60 70 80 90 100
FYLFGFLSAG YLCCVLWGWF SACGLDIVLW SFLLAVVCLL QLAHLVYRLR
110 120 130 140 150
EDTLPEEFDL LYKTLCLPLQ VPLQTYKEIV HCCEEQVLTL ATEQTYAVEG
160 170 180 190 200
ETPINRLSLL LSGRVRVSQD GQFLHYIFPY QFMDSPEWES LQPSEEGVFQ
210 220 230 240 250
VTLTAETSCS YISWPRKSLH LLLTKERYIS CLFSALLGYD ISEKLYTLND
260 270 280 290 300
KLFAKFGLRF DIRLPSLYHV LGPTAADAGP ESEKGDEEVC EPAVSPPQAT
310 320 330 340 350
PTSLQQTPPC STPPATTNFP APPTRARLSR PDSGILASRI PLQSYSQVIS
360
RGQAPLAPTH TPEL
Length:364
Mass (Da):40,448
Last modified:October 31, 2003 - v2
Checksum:iF29AA48CD611BE51
GO
Isoform 2 (identifier: Q9HBU9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-364: ASRIPLQSYSQVISRGQAPLAPTHTPEL → EIDDFPSYFHQFGFSGKVAAGRIP

Note: No experimental confirmation available.
Show »
Length:360
Mass (Da):40,115
Checksum:i497BDAC0D50C6EE9
GO

Sequence cautioni

The sequence AAH26911 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti311S → F in AAG23406 (PubMed:10882522).Curated1
Sequence conflicti315 – 328ATTNF…TRARL → RFPPTFPALSYRGQVC in AAG23406 (PubMed:10882522).CuratedAdd BLAST14
Sequence conflicti331 – 333PDS → ASN in AAG23406 (PubMed:10882522).Curated3
Sequence conflicti339R → K in AAG23406 (PubMed:10882522).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05360129V → I.Corresponds to variant rs4688023dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008743337 – 364ASRIP…HTPEL → EIDDFPSYFHQFGFSGKVAA GRIP in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204173 mRNA. Translation: AAG23406.1.
BC026911 mRNA. Translation: AAH26911.1. Different initiation.
BC044929 mRNA. Translation: AAH44929.1.
CCDSiCCDS2992.1. [Q9HBU9-1]
CCDS77797.1. [Q9HBU9-2]
RefSeqiNP_001295262.1. NM_001308333.1. [Q9HBU9-2]
NP_071418.2. NM_022135.3. [Q9HBU9-1]
UniGeneiHs.534383.
Hs.656031.

Genome annotation databases

EnsembliENST00000264231; ENSP00000264231; ENSG00000121577. [Q9HBU9-1]
ENST00000468801; ENSP00000420715; ENSG00000121577. [Q9HBU9-2]
GeneIDi64091.
KEGGihsa:64091.
UCSCiuc003ecx.2. human. [Q9HBU9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204173 mRNA. Translation: AAG23406.1.
BC026911 mRNA. Translation: AAH26911.1. Different initiation.
BC044929 mRNA. Translation: AAH44929.1.
CCDSiCCDS2992.1. [Q9HBU9-1]
CCDS77797.1. [Q9HBU9-2]
RefSeqiNP_001295262.1. NM_001308333.1. [Q9HBU9-2]
NP_071418.2. NM_022135.3. [Q9HBU9-1]
UniGeneiHs.534383.
Hs.656031.

3D structure databases

ProteinModelPortaliQ9HBU9.
SMRiQ9HBU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122053. 22 interactors.
IntActiQ9HBU9. 1 interactor.
MINTiMINT-6544493.
STRINGi9606.ENSP00000264231.

PTM databases

iPTMnetiQ9HBU9.
PhosphoSitePlusiQ9HBU9.

Polymorphism and mutation databases

BioMutaiPOPDC2.
DMDMi38258244.

Proteomic databases

PaxDbiQ9HBU9.
PeptideAtlasiQ9HBU9.
PRIDEiQ9HBU9.

Protocols and materials databases

DNASUi64091.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264231; ENSP00000264231; ENSG00000121577. [Q9HBU9-1]
ENST00000468801; ENSP00000420715; ENSG00000121577. [Q9HBU9-2]
GeneIDi64091.
KEGGihsa:64091.
UCSCiuc003ecx.2. human. [Q9HBU9-1]

Organism-specific databases

CTDi64091.
GeneCardsiPOPDC2.
HGNCiHGNC:17648. POPDC2.
HPAiHPA024255.
MIMi605823. gene.
neXtProtiNX_Q9HBU9.
OpenTargetsiENSG00000121577.
PharmGKBiPA134982197.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGHK. Eukaryota.
ENOG410ZTIT. LUCA.
GeneTreeiENSGT00390000002563.
HOGENOMiHOG000050233.
HOVERGENiHBG053639.
InParanoidiQ9HBU9.
PhylomeDBiQ9HBU9.
TreeFamiTF326644.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121577-MONOMER.

Miscellaneous databases

GeneWikiiPOPDC2.
GenomeRNAii64091.
PROiQ9HBU9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121577.
CleanExiHS_POPDC2.
ExpressionAtlasiQ9HBU9. baseline and differential.
GenevisibleiQ9HBU9. HS.

Family and domain databases

InterProiIPR018490. cNMP-bd-like.
IPR006916. Popeye_prot.
[Graphical view]
PANTHERiPTHR12101. PTHR12101. 1 hit.
PfamiPF04831. Popeye. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPOPD2_HUMAN
AccessioniPrimary (citable) accession number: Q9HBU9
Secondary accession number(s): Q86UE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.