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Q9HBU9

- POPD2_HUMAN

UniProt

Q9HBU9 - POPD2_HUMAN

Protein

Popeye domain-containing protein 2

Gene

POPDC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (31 Oct 2003)
      Previous versions | rss
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    Functioni

    May play an important role in heart development.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Popeye domain-containing protein 2
    Short name:
    Popeye protein 2
    Gene namesi
    Name:POPDC2
    Synonyms:POP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:17648. POPDC2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134982197.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Popeye domain-containing protein 2PRO_0000046793Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9HBU9.
    PRIDEiQ9HBU9.

    PTM databases

    PhosphoSiteiQ9HBU9.

    Expressioni

    Tissue specificityi

    Expressed predominantly in the heart, and is also detected in the skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ9HBU9.
    BgeeiQ9HBU9.
    CleanExiHS_POPDC2.
    GenevestigatoriQ9HBU9.

    Organism-specific databases

    HPAiHPA024255.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9HBU9. 1 interaction.
    MINTiMINT-6544493.
    STRINGi9606.ENSP00000264231.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HBU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the popeye family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG84367.
    HOGENOMiHOG000050233.
    HOVERGENiHBG053639.
    InParanoidiQ9HBU9.
    PhylomeDBiQ9HBU9.
    TreeFamiTF326644.

    Family and domain databases

    InterProiIPR018490. cNMP-bd-like.
    IPR006916. Popeye_prot.
    [Graphical view]
    PANTHERiPTHR12101. PTHR12101. 1 hit.
    PfamiPF04831. Popeye. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HBU9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSANSSRVGQ LLLQGSACIR WKQDVEGAVY HLANCLLLLG FMGGSGVYGC    50
    FYLFGFLSAG YLCCVLWGWF SACGLDIVLW SFLLAVVCLL QLAHLVYRLR 100
    EDTLPEEFDL LYKTLCLPLQ VPLQTYKEIV HCCEEQVLTL ATEQTYAVEG 150
    ETPINRLSLL LSGRVRVSQD GQFLHYIFPY QFMDSPEWES LQPSEEGVFQ 200
    VTLTAETSCS YISWPRKSLH LLLTKERYIS CLFSALLGYD ISEKLYTLND 250
    KLFAKFGLRF DIRLPSLYHV LGPTAADAGP ESEKGDEEVC EPAVSPPQAT 300
    PTSLQQTPPC STPPATTNFP APPTRARLSR PDSGILASRI PLQSYSQVIS 350
    RGQAPLAPTH TPEL 364
    Length:364
    Mass (Da):40,448
    Last modified:October 31, 2003 - v2
    Checksum:iF29AA48CD611BE51
    GO
    Isoform 2 (identifier: Q9HBU9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         337-364: ASRIPLQSYSQVISRGQAPLAPTHTPEL → EIDDFPSYFHQFGFSGKVAAGRIP

    Note: No experimental confirmation available.

    Show »
    Length:360
    Mass (Da):40,115
    Checksum:i497BDAC0D50C6EE9
    GO

    Sequence cautioni

    The sequence AAH26911.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti311 – 3111S → F in AAG23406. (PubMed:10882522)Curated
    Sequence conflicti315 – 32814ATTNF…TRARL → RFPPTFPALSYRGQVC(PubMed:10882522)CuratedAdd
    BLAST
    Sequence conflicti331 – 3333PDS → ASN(PubMed:10882522)Curated
    Sequence conflicti339 – 3391R → K in AAG23406. (PubMed:10882522)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291V → I.
    Corresponds to variant rs4688023 [ dbSNP | Ensembl ].
    VAR_053601

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei337 – 36428ASRIP…HTPEL → EIDDFPSYFHQFGFSGKVAA GRIP in isoform 2. 1 PublicationVSP_008743Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF204173 mRNA. Translation: AAG23406.1.
    BC026911 mRNA. Translation: AAH26911.1. Different initiation.
    BC044929 mRNA. Translation: AAH44929.1.
    CCDSiCCDS2992.1. [Q9HBU9-1]
    RefSeqiNP_071418.2. NM_022135.2. [Q9HBU9-1]
    XP_005247756.1. XM_005247699.1. [Q9HBU9-2]
    UniGeneiHs.534383.
    Hs.656031.

    Genome annotation databases

    EnsembliENST00000264231; ENSP00000264231; ENSG00000121577. [Q9HBU9-1]
    ENST00000468801; ENSP00000420715; ENSG00000121577. [Q9HBU9-2]
    GeneIDi64091.
    KEGGihsa:64091.
    UCSCiuc003ecx.1. human. [Q9HBU9-1]
    uc010hqw.1. human. [Q9HBU9-2]

    Polymorphism databases

    DMDMi38258244.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF204173 mRNA. Translation: AAG23406.1 .
    BC026911 mRNA. Translation: AAH26911.1 . Different initiation.
    BC044929 mRNA. Translation: AAH44929.1 .
    CCDSi CCDS2992.1. [Q9HBU9-1 ]
    RefSeqi NP_071418.2. NM_022135.2. [Q9HBU9-1 ]
    XP_005247756.1. XM_005247699.1. [Q9HBU9-2 ]
    UniGenei Hs.534383.
    Hs.656031.

    3D structure databases

    ProteinModelPortali Q9HBU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9HBU9. 1 interaction.
    MINTi MINT-6544493.
    STRINGi 9606.ENSP00000264231.

    PTM databases

    PhosphoSitei Q9HBU9.

    Polymorphism databases

    DMDMi 38258244.

    Proteomic databases

    PaxDbi Q9HBU9.
    PRIDEi Q9HBU9.

    Protocols and materials databases

    DNASUi 64091.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264231 ; ENSP00000264231 ; ENSG00000121577 . [Q9HBU9-1 ]
    ENST00000468801 ; ENSP00000420715 ; ENSG00000121577 . [Q9HBU9-2 ]
    GeneIDi 64091.
    KEGGi hsa:64091.
    UCSCi uc003ecx.1. human. [Q9HBU9-1 ]
    uc010hqw.1. human. [Q9HBU9-2 ]

    Organism-specific databases

    CTDi 64091.
    GeneCardsi GC03M119355.
    HGNCi HGNC:17648. POPDC2.
    HPAi HPA024255.
    MIMi 605823. gene.
    neXtProti NX_Q9HBU9.
    PharmGKBi PA134982197.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84367.
    HOGENOMi HOG000050233.
    HOVERGENi HBG053639.
    InParanoidi Q9HBU9.
    PhylomeDBi Q9HBU9.
    TreeFami TF326644.

    Miscellaneous databases

    GeneWikii POPDC2.
    GenomeRNAii 64091.
    NextBioi 65900.
    PROi Q9HBU9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HBU9.
    Bgeei Q9HBU9.
    CleanExi HS_POPDC2.
    Genevestigatori Q9HBU9.

    Family and domain databases

    InterProi IPR018490. cNMP-bd-like.
    IPR006916. Popeye_prot.
    [Graphical view ]
    PANTHERi PTHR12101. PTHR12101. 1 hit.
    Pfami PF04831. Popeye. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart."
      Andree B., Hillemann T., Kessler-Icekson G., Schmitt-John T., Jockusch H., Arnold H.-H., Brand T.
      Dev. Biol. 223:371-382(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), POSSIBLE FUNCTION, TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Colon, Kidney, Stomach and Urinary bladder.

    Entry informationi

    Entry nameiPOPD2_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBU9
    Secondary accession number(s): Q86UE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: October 31, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3