Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9HBU6

- EKI1_HUMAN

UniProt

Q9HBU6 - EKI1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ethanolamine kinase 1

Gene

ETNK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.

Catalytic activityi

ATP + ethanolamine = ADP + O-phosphoethanolamine.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ethanolamine kinase activity Source: UniProtKB

GO - Biological processi

  1. glycerophospholipid biosynthetic process Source: Reactome
  2. phosphatidylethanolamine biosynthetic process Source: UniProtKB
  3. phospholipid metabolic process Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.82. 2681.
ReactomeiREACT_120919. Synthesis of PE.
UniPathwayiUPA00558; UER00741.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethanolamine kinase 1 (EC:2.7.1.82)
Short name:
EKI 1
Gene namesi
Name:ETNK1
Synonyms:EKI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:24649. ETNK1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134921265.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Ethanolamine kinase 1PRO_0000206227Add
BLAST

Proteomic databases

MaxQBiQ9HBU6.
PaxDbiQ9HBU6.
PRIDEiQ9HBU6.

PTM databases

PhosphoSiteiQ9HBU6.

Expressioni

Tissue specificityi

Expressed in kidney, liver, placenta, heart, leukocyte, ovary and testis.

Gene expression databases

BgeeiQ9HBU6.
CleanExiHS_ETNK1.
ExpressionAtlasiQ9HBU6. baseline and differential.
GenevestigatoriQ9HBU6.

Organism-specific databases

HPAiHPA010712.
HPA029407.

Interactioni

Protein-protein interaction databases

BioGridi120680. 1 interaction.
IntActiQ9HBU6. 1 interaction.
STRINGi9606.ENSP00000266517.

Structurei

3D structure databases

ProteinModelPortaliQ9HBU6.
SMRiQ9HBU6. Positions 146-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi73 – 8311Poly-ValAdd
BLAST

Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

eggNOGiCOG0510.
GeneTreeiENSGT00530000062991.
HOGENOMiHOG000004856.
HOVERGENiHBG018981.
InParanoidiQ9HBU6.
KOiK00894.
OMAiQEEMAWM.
OrthoDBiEOG72NRQH.
PhylomeDBiQ9HBU6.
TreeFamiTF313549.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HBU6) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCGRPRSSS DNRNFLRERA GLSSAAVQTR IGNSAASRRS PAARPPVPAP
60 70 80 90 100
PALPRGRPGT EGSTSLSAPA VLVVAVAVVV VVVSAVAWAM ANYIHVPPGS
110 120 130 140 150
PEVPKLNVTV QDQEEHRCRE GALSLLQHLR PHWDPQEVTL QLFTDGITNK
160 170 180 190 200
LIGCYVGNTM EDVVLVRIYG NKTELLVDRD EEVKSFRVLQ AHGCAPQLYC
210 220 230 240 250
TFNNGLCYEF IQGEALDPKH VCNPAIFRLI ARQLAKIHAI HAHNGWIPKS
260 270 280 290 300
NLWLKMGKYF SLIPTGFADE DINKRFLSDI PSSQILQEEM TWMKEILSNL
310 320 330 340 350
GSPVVLCHND LLCKNIIYNE KQGDVQFIDY EYSGYNYLAY DIGNHFNEFA
360 370 380 390 400
GVSDVDYSLY PDRELQSQWL RAYLEAYKEF KGFGTEVTEK EVEILFIQVN
410 420 430 440 450
QFALASHFFW GLWALIQAKY STIEFDFLGY AIVRFNQYFK MKPEVTALKV

PE
Length:452
Mass (Da):50,968
Last modified:March 1, 2001 - v1
Checksum:i9AF29EAC556ED91F
GO
Isoform 2 (identifier: Q9HBU6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-452: RLIARQLAKI...PEVTALKVPE → SLSSLTLCKGKTTRCFGLTGCRGSRLLLSFF

Note: No experimental confirmation available.

Show »
Length:258
Mass (Da):27,995
Checksum:iED3BD93928986C4A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei228 – 452225RLIAR…LKVPE → SLSSLTLCKGKTTRCFGLTG CRGSRLLLSFF in isoform 2. 1 PublicationVSP_047191Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF207600 mRNA. Translation: AAF71220.2.
AC087241 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96479.1.
BC006111 mRNA. Translation: AAH06111.2.
BC066907 mRNA. Translation: AAH66907.1.
CCDSiCCDS41760.1. [Q9HBU6-2]
CCDS8698.1. [Q9HBU6-1]
RefSeqiNP_001034570.1. NM_001039481.1. [Q9HBU6-2]
NP_061108.2. NM_018638.4. [Q9HBU6-1]
UniGeneiHs.29464.

Genome annotation databases

EnsembliENST00000266517; ENSP00000266517; ENSG00000139163. [Q9HBU6-1]
ENST00000335148; ENSP00000334041; ENSG00000139163. [Q9HBU6-2]
GeneIDi55500.
KEGGihsa:55500.
UCSCiuc001rfs.3. human.
uc001rft.3. human. [Q9HBU6-1]

Polymorphism databases

DMDMi14194724.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF207600 mRNA. Translation: AAF71220.2 .
AC087241 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96479.1 .
BC006111 mRNA. Translation: AAH06111.2 .
BC066907 mRNA. Translation: AAH66907.1 .
CCDSi CCDS41760.1. [Q9HBU6-2 ]
CCDS8698.1. [Q9HBU6-1 ]
RefSeqi NP_001034570.1. NM_001039481.1. [Q9HBU6-2 ]
NP_061108.2. NM_018638.4. [Q9HBU6-1 ]
UniGenei Hs.29464.

3D structure databases

ProteinModelPortali Q9HBU6.
SMRi Q9HBU6. Positions 146-442.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120680. 1 interaction.
IntActi Q9HBU6. 1 interaction.
STRINGi 9606.ENSP00000266517.

PTM databases

PhosphoSitei Q9HBU6.

Polymorphism databases

DMDMi 14194724.

Proteomic databases

MaxQBi Q9HBU6.
PaxDbi Q9HBU6.
PRIDEi Q9HBU6.

Protocols and materials databases

DNASUi 55500.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266517 ; ENSP00000266517 ; ENSG00000139163 . [Q9HBU6-1 ]
ENST00000335148 ; ENSP00000334041 ; ENSG00000139163 . [Q9HBU6-2 ]
GeneIDi 55500.
KEGGi hsa:55500.
UCSCi uc001rfs.3. human.
uc001rft.3. human. [Q9HBU6-1 ]

Organism-specific databases

CTDi 55500.
GeneCardsi GC12P022778.
HGNCi HGNC:24649. ETNK1.
HPAi HPA010712.
HPA029407.
MIMi 609858. gene.
neXtProti NX_Q9HBU6.
PharmGKBi PA134921265.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0510.
GeneTreei ENSGT00530000062991.
HOGENOMi HOG000004856.
HOVERGENi HBG018981.
InParanoidi Q9HBU6.
KOi K00894.
OMAi QEEMAWM.
OrthoDBi EOG72NRQH.
PhylomeDBi Q9HBU6.
TreeFami TF313549.

Enzyme and pathway databases

UniPathwayi UPA00558 ; UER00741 .
BRENDAi 2.7.1.82. 2681.
Reactomei REACT_120919. Synthesis of PE.

Miscellaneous databases

GenomeRNAii 55500.
NextBioi 59873.
PROi Q9HBU6.
SOURCEi Search...

Gene expression databases

Bgeei Q9HBU6.
CleanExi HS_ETNK1.
ExpressionAtlasi Q9HBU6. baseline and differential.
Genevestigatori Q9HBU6.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway."
    Lykidis A., Wang J., Karim M.A., Jackowski S.
    J. Biol. Chem. 276:2174-2179(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEKI1_HUMAN
AccessioniPrimary (citable) accession number: Q9HBU6
Secondary accession number(s): G5E969
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3