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Q9HBU6

- EKI1_HUMAN

UniProt

Q9HBU6 - EKI1_HUMAN

Protein

Ethanolamine kinase 1

Gene

ETNK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.

    Catalytic activityi

    ATP + ethanolamine = ADP + O-phosphoethanolamine.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ethanolamine kinase activity Source: UniProtKB

    GO - Biological processi

    1. glycerophospholipid biosynthetic process Source: Reactome
    2. phosphatidylethanolamine biosynthetic process Source: UniProtKB
    3. phospholipid metabolic process Source: Reactome
    4. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.1.82. 2681.
    ReactomeiREACT_120919. Synthesis of PE.
    UniPathwayiUPA00558; UER00741.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ethanolamine kinase 1 (EC:2.7.1.82)
    Short name:
    EKI 1
    Gene namesi
    Name:ETNK1
    Synonyms:EKI1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24649. ETNK1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134921265.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Ethanolamine kinase 1PRO_0000206227Add
    BLAST

    Proteomic databases

    MaxQBiQ9HBU6.
    PaxDbiQ9HBU6.
    PRIDEiQ9HBU6.

    PTM databases

    PhosphoSiteiQ9HBU6.

    Expressioni

    Tissue specificityi

    Expressed in kidney, liver, placenta, heart, leukocyte, ovary and testis.

    Gene expression databases

    ArrayExpressiQ9HBU6.
    BgeeiQ9HBU6.
    CleanExiHS_ETNK1.
    GenevestigatoriQ9HBU6.

    Organism-specific databases

    HPAiHPA010712.
    HPA029407.

    Interactioni

    Protein-protein interaction databases

    BioGridi120680. 1 interaction.
    IntActiQ9HBU6. 1 interaction.
    STRINGi9606.ENSP00000266517.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HBU6.
    SMRiQ9HBU6. Positions 146-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi73 – 8311Poly-ValAdd
    BLAST

    Sequence similaritiesi

    Belongs to the choline/ethanolamine kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0510.
    HOGENOMiHOG000004856.
    HOVERGENiHBG018981.
    InParanoidiQ9HBU6.
    KOiK00894.
    OMAiQEEMAWM.
    OrthoDBiEOG72NRQH.
    PhylomeDBiQ9HBU6.
    TreeFamiTF313549.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HBU6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLCGRPRSSS DNRNFLRERA GLSSAAVQTR IGNSAASRRS PAARPPVPAP    50
    PALPRGRPGT EGSTSLSAPA VLVVAVAVVV VVVSAVAWAM ANYIHVPPGS 100
    PEVPKLNVTV QDQEEHRCRE GALSLLQHLR PHWDPQEVTL QLFTDGITNK 150
    LIGCYVGNTM EDVVLVRIYG NKTELLVDRD EEVKSFRVLQ AHGCAPQLYC 200
    TFNNGLCYEF IQGEALDPKH VCNPAIFRLI ARQLAKIHAI HAHNGWIPKS 250
    NLWLKMGKYF SLIPTGFADE DINKRFLSDI PSSQILQEEM TWMKEILSNL 300
    GSPVVLCHND LLCKNIIYNE KQGDVQFIDY EYSGYNYLAY DIGNHFNEFA 350
    GVSDVDYSLY PDRELQSQWL RAYLEAYKEF KGFGTEVTEK EVEILFIQVN 400
    QFALASHFFW GLWALIQAKY STIEFDFLGY AIVRFNQYFK MKPEVTALKV 450
    PE 452
    Length:452
    Mass (Da):50,968
    Last modified:March 1, 2001 - v1
    Checksum:i9AF29EAC556ED91F
    GO
    Isoform 2 (identifier: Q9HBU6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         228-452: RLIARQLAKI...PEVTALKVPE → SLSSLTLCKGKTTRCFGLTGCRGSRLLLSFF

    Note: No experimental confirmation available.

    Show »
    Length:258
    Mass (Da):27,995
    Checksum:iED3BD93928986C4A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei228 – 452225RLIAR…LKVPE → SLSSLTLCKGKTTRCFGLTG CRGSRLLLSFF in isoform 2. 1 PublicationVSP_047191Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF207600 mRNA. Translation: AAF71220.2.
    AC087241 Genomic DNA. No translation available.
    CH471094 Genomic DNA. Translation: EAW96479.1.
    BC006111 mRNA. Translation: AAH06111.2.
    BC066907 mRNA. Translation: AAH66907.1.
    CCDSiCCDS41760.1. [Q9HBU6-2]
    CCDS8698.1. [Q9HBU6-1]
    RefSeqiNP_001034570.1. NM_001039481.1. [Q9HBU6-2]
    NP_061108.2. NM_018638.4. [Q9HBU6-1]
    UniGeneiHs.29464.

    Genome annotation databases

    EnsembliENST00000266517; ENSP00000266517; ENSG00000139163. [Q9HBU6-1]
    ENST00000335148; ENSP00000334041; ENSG00000139163. [Q9HBU6-2]
    GeneIDi55500.
    KEGGihsa:55500.
    UCSCiuc001rfs.3. human.
    uc001rft.3. human. [Q9HBU6-1]

    Polymorphism databases

    DMDMi14194724.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF207600 mRNA. Translation: AAF71220.2 .
    AC087241 Genomic DNA. No translation available.
    CH471094 Genomic DNA. Translation: EAW96479.1 .
    BC006111 mRNA. Translation: AAH06111.2 .
    BC066907 mRNA. Translation: AAH66907.1 .
    CCDSi CCDS41760.1. [Q9HBU6-2 ]
    CCDS8698.1. [Q9HBU6-1 ]
    RefSeqi NP_001034570.1. NM_001039481.1. [Q9HBU6-2 ]
    NP_061108.2. NM_018638.4. [Q9HBU6-1 ]
    UniGenei Hs.29464.

    3D structure databases

    ProteinModelPortali Q9HBU6.
    SMRi Q9HBU6. Positions 146-442.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120680. 1 interaction.
    IntActi Q9HBU6. 1 interaction.
    STRINGi 9606.ENSP00000266517.

    PTM databases

    PhosphoSitei Q9HBU6.

    Polymorphism databases

    DMDMi 14194724.

    Proteomic databases

    MaxQBi Q9HBU6.
    PaxDbi Q9HBU6.
    PRIDEi Q9HBU6.

    Protocols and materials databases

    DNASUi 55500.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266517 ; ENSP00000266517 ; ENSG00000139163 . [Q9HBU6-1 ]
    ENST00000335148 ; ENSP00000334041 ; ENSG00000139163 . [Q9HBU6-2 ]
    GeneIDi 55500.
    KEGGi hsa:55500.
    UCSCi uc001rfs.3. human.
    uc001rft.3. human. [Q9HBU6-1 ]

    Organism-specific databases

    CTDi 55500.
    GeneCardsi GC12P022778.
    HGNCi HGNC:24649. ETNK1.
    HPAi HPA010712.
    HPA029407.
    MIMi 609858. gene.
    neXtProti NX_Q9HBU6.
    PharmGKBi PA134921265.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0510.
    HOGENOMi HOG000004856.
    HOVERGENi HBG018981.
    InParanoidi Q9HBU6.
    KOi K00894.
    OMAi QEEMAWM.
    OrthoDBi EOG72NRQH.
    PhylomeDBi Q9HBU6.
    TreeFami TF313549.

    Enzyme and pathway databases

    UniPathwayi UPA00558 ; UER00741 .
    BRENDAi 2.7.1.82. 2681.
    Reactomei REACT_120919. Synthesis of PE.

    Miscellaneous databases

    GenomeRNAii 55500.
    NextBioi 59873.
    PROi Q9HBU6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HBU6.
    Bgeei Q9HBU6.
    CleanExi HS_ETNK1.
    Genevestigatori Q9HBU6.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway."
      Lykidis A., Wang J., Karim M.A., Jackowski S.
      J. Biol. Chem. 276:2174-2179(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiEKI1_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBU6
    Secondary accession number(s): G5E969
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3