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Q9HBT8 (Z286A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 286A
Gene names
Name:ZNF286A
Synonyms:KIAA1874, ZNF286
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 10 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence BAB47503.2 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 521521Zinc finger protein 286A
PRO_0000047510

Regions

Domain45 – 11167KRAB
Zinc finger243 – 26523C2H2-type 1
Zinc finger271 – 29323C2H2-type 2
Zinc finger298 – 32023C2H2-type 3
Zinc finger326 – 34823C2H2-type 4
Zinc finger354 – 37623C2H2-type 5
Zinc finger382 – 40423C2H2-type 6
Zinc finger410 – 43223C2H2-type 7
Zinc finger438 – 46023C2H2-type 8
Zinc finger466 – 48823C2H2-type 9
Zinc finger494 – 51623C2H2-type 10

Natural variations

Natural variant901Y → H. Ref.2
Corresponds to variant rs3760299 [ dbSNP | Ensembl ].
VAR_021892

Sequences

Sequence LengthMass (Da)Tools
Q9HBT8 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 485C3FF3DD210DBB

FASTA52160,175
        10         20         30         40         50         60 
METDLAEMPE KGALSSQDSP HFQEKSTEEG EVAALRLTAR SQETVTFKDV AMDFTPEEWG 

        70         80         90        100        110        120 
KLDPAQRDVM LENYRNLVSL WLPVSKPESY NLENGKEPLK LERKAPKSSY SDMETRPQSK 

       130        140        150        160        170        180 
DSTSVQDFSK AESCKVAIID RLTRNSVYDS NLEAALECEN WLENQQGNQE RHLREMFTHM 

       190        200        210        220        230        240 
NSLSEETDHK HDVYWKSFNQ KSVLITEDRV PKGSYAFHTL EKSLKQKSNL MKKQRTYKEK 

       250        260        270        280        290        300 
KPHKCNDCGE LFTYHSVLIR HQRVHTGEKP YTCNECGKSF SHRANLTKHQ RTHTRILFEC 

       310        320        330        340        350        360 
SECKKTFTES SSLATHQRIH VGERPYECNE CGKGFNRSTH LVQHQLIHTG VKPYECNECD 

       370        380        390        400        410        420 
KAFIHSSALI KHQRTHTGEK PYKCQECGKA FSHCSSLTKH QRVHTGEKPY ECSECGKTFS 

       430        440        450        460        470        480 
QSTHLVQHQR IHTGEKPYEC NECGKTFSRS SNFAKHQRIH IGKKPYKCSE CGKAFIHSSA 

       490        500        510        520 
LIQHQRTHTG EKPFRCNECG KSFKCSSSLI RHQRVHTEEQ P 

« Hide

References

« Hide 'large scale' references
[1]"Deletion of a novel zinc finger gene in Smith-Magenis syndrome."
Romero-Pastrana F., Srivastava A.K.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-90.
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO N-TERMINUS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF217226 mRNA. Translation: AAG09701.1.
AB058777 mRNA. Translation: BAB47503.2. Different initiation.
CCDSCCDS11172.1.
RefSeqNP_001124314.1. NM_001130842.1.
NP_001275571.1. NM_001288642.1.
NP_001275572.1. NM_001288643.1.
NP_001275573.1. NM_001288644.1.
NP_001275574.1. NM_001288645.1.
NP_001275575.1. NM_001288646.1.
NP_001275576.1. NM_001288647.1.
NP_001275577.1. NM_001288648.1.
NP_001275578.1. NM_001288649.1.
NP_065703.1. NM_020652.2.
UniGeneHs.585799.
Hs.659318.

3D structure databases

ProteinModelPortalQ9HBT8.
SMRQ9HBT8. Positions 179-521.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121489. 1 interaction.

PTM databases

PhosphoSiteQ9HBT8.

Polymorphism databases

DMDM20141039.

Proteomic databases

MaxQBQ9HBT8.
PaxDbQ9HBT8.
PRIDEQ9HBT8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000413242; ENSP00000458062; ENSG00000255104.
GeneID57335.
KEGGhsa:57335.
UCSCuc002goz.4. human.

Organism-specific databases

CTD57335.
GeneCardsGC17P015602.
GC17P015604.
HGNCHGNC:13501. ZNF286A.
neXtProtNX_Q9HBT8.
PharmGKBPA162410066.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ9HBT8.
KOK09228.
OMAVSKPENY.
PhylomeDBQ9HBT8.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9HBT8.
BgeeQ9HBT8.
CleanExHS_ZNF286A.
GenevestigatorQ9HBT8.

Family and domain databases

Gene3D3.30.160.60. 10 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi57335.
NextBio63446.
PROQ9HBT8.

Entry information

Entry nameZ286A_HUMAN
AccessionPrimary (citable) accession number: Q9HBT8
Secondary accession number(s): Q96JF3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM