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Protein

Zinc finger protein 286A

Gene

ZNF286A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri243 – 26523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 286A
Gene namesi
Name:ZNF286A
Synonyms:KIAA1874, ZNF286
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:13501. ZNF286A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410066.

Polymorphism and mutation databases

BioMutaiZNF286A.
DMDMi20141039.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Zinc finger protein 286APRO_0000047510Add
BLAST

Proteomic databases

MaxQBiQ9HBT8.
PaxDbiQ9HBT8.
PRIDEiQ9HBT8.

PTM databases

PhosphoSiteiQ9HBT8.

Expressioni

Gene expression databases

BgeeiQ9HBT8.
CleanExiHS_ZNF286A.
ExpressionAtlasiQ9HBT8. baseline and differential.
GenevisibleiQ9HBT8. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-10310244,EBI-10171697
KRTAP10-5P603703EBI-10310244,EBI-10172150

Protein-protein interaction databases

BioGridi121489. 3 interactions.
IntActiQ9HBT8. 2 interactions.
STRINGi9606.ENSP00000458062.

Structurei

3D structure databases

ProteinModelPortaliQ9HBT8.
SMRiQ9HBT8. Positions 179-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 11167KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri243 – 26523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119202.
ENSGT00770000120517.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9HBT8.
KOiK09228.
OMAiFHTLEKR.
PhylomeDBiQ9HBT8.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HBT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METDLAEMPE KGALSSQDSP HFQEKSTEEG EVAALRLTAR SQETVTFKDV
60 70 80 90 100
AMDFTPEEWG KLDPAQRDVM LENYRNLVSL WLPVSKPESY NLENGKEPLK
110 120 130 140 150
LERKAPKSSY SDMETRPQSK DSTSVQDFSK AESCKVAIID RLTRNSVYDS
160 170 180 190 200
NLEAALECEN WLENQQGNQE RHLREMFTHM NSLSEETDHK HDVYWKSFNQ
210 220 230 240 250
KSVLITEDRV PKGSYAFHTL EKSLKQKSNL MKKQRTYKEK KPHKCNDCGE
260 270 280 290 300
LFTYHSVLIR HQRVHTGEKP YTCNECGKSF SHRANLTKHQ RTHTRILFEC
310 320 330 340 350
SECKKTFTES SSLATHQRIH VGERPYECNE CGKGFNRSTH LVQHQLIHTG
360 370 380 390 400
VKPYECNECD KAFIHSSALI KHQRTHTGEK PYKCQECGKA FSHCSSLTKH
410 420 430 440 450
QRVHTGEKPY ECSECGKTFS QSTHLVQHQR IHTGEKPYEC NECGKTFSRS
460 470 480 490 500
SNFAKHQRIH IGKKPYKCSE CGKAFIHSSA LIQHQRTHTG EKPFRCNECG
510 520
KSFKCSSSLI RHQRVHTEEQ P
Length:521
Mass (Da):60,175
Last modified:March 1, 2001 - v1
Checksum:i485C3FF3DD210DBB
GO
Isoform 2 (identifier: Q9HBT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: METDLAEMPEK → M

Note: No experimental confirmation available.
Show »
Length:511
Mass (Da):59,030
Checksum:i2F65FAD9386E8F75
GO

Sequence cautioni

The sequence BAB47503.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901Y → H.1 Publication
Corresponds to variant rs3760299 [ dbSNP | Ensembl ].
VAR_021892

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1111METDLAEMPEK → M in isoform 2. 1 PublicationVSP_056673Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217226 mRNA. Translation: AAG09701.1.
AB058777 mRNA. Translation: BAB47503.2. Different initiation.
AK296547 mRNA. Translation: BAG59171.1.
AC005324 Genomic DNA. No translation available.
CCDSiCCDS11172.1. [Q9HBT8-1]
CCDS73997.1. [Q9HBT8-2]
RefSeqiNP_001124314.1. NM_001130842.1. [Q9HBT8-1]
NP_001275571.1. NM_001288642.1.
NP_001275572.1. NM_001288643.1. [Q9HBT8-2]
NP_001275573.1. NM_001288644.1.
NP_001275574.1. NM_001288645.1.
NP_001275575.1. NM_001288646.1.
NP_001275576.1. NM_001288647.1.
NP_001275577.1. NM_001288648.1.
NP_001275578.1. NM_001288649.1.
NP_065703.1. NM_020652.2. [Q9HBT8-1]
UniGeneiHs.585799.
Hs.659318.

Genome annotation databases

EnsembliENST00000412988; ENSP00000408168; ENSG00000255104. [Q9HBT8-2]
ENST00000413242; ENSP00000458062; ENSG00000255104.
ENST00000421016; ENSP00000397163; ENSG00000187607.
ENST00000464847; ENSP00000464218; ENSG00000187607.
ENST00000583566; ENSP00000464063; ENSG00000187607.
ENST00000593105; ENSP00000466154; ENSG00000187607. [Q9HBT8-2]
GeneIDi57335.
KEGGihsa:57335.
UCSCiuc002goz.4. human. [Q9HBT8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217226 mRNA. Translation: AAG09701.1.
AB058777 mRNA. Translation: BAB47503.2. Different initiation.
AK296547 mRNA. Translation: BAG59171.1.
AC005324 Genomic DNA. No translation available.
CCDSiCCDS11172.1. [Q9HBT8-1]
CCDS73997.1. [Q9HBT8-2]
RefSeqiNP_001124314.1. NM_001130842.1. [Q9HBT8-1]
NP_001275571.1. NM_001288642.1.
NP_001275572.1. NM_001288643.1. [Q9HBT8-2]
NP_001275573.1. NM_001288644.1.
NP_001275574.1. NM_001288645.1.
NP_001275575.1. NM_001288646.1.
NP_001275576.1. NM_001288647.1.
NP_001275577.1. NM_001288648.1.
NP_001275578.1. NM_001288649.1.
NP_065703.1. NM_020652.2. [Q9HBT8-1]
UniGeneiHs.585799.
Hs.659318.

3D structure databases

ProteinModelPortaliQ9HBT8.
SMRiQ9HBT8. Positions 179-521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121489. 3 interactions.
IntActiQ9HBT8. 2 interactions.
STRINGi9606.ENSP00000458062.

PTM databases

PhosphoSiteiQ9HBT8.

Polymorphism and mutation databases

BioMutaiZNF286A.
DMDMi20141039.

Proteomic databases

MaxQBiQ9HBT8.
PaxDbiQ9HBT8.
PRIDEiQ9HBT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412988; ENSP00000408168; ENSG00000255104. [Q9HBT8-2]
ENST00000413242; ENSP00000458062; ENSG00000255104.
ENST00000421016; ENSP00000397163; ENSG00000187607.
ENST00000464847; ENSP00000464218; ENSG00000187607.
ENST00000583566; ENSP00000464063; ENSG00000187607.
ENST00000593105; ENSP00000466154; ENSG00000187607. [Q9HBT8-2]
GeneIDi57335.
KEGGihsa:57335.
UCSCiuc002goz.4. human. [Q9HBT8-1]

Organism-specific databases

CTDi57335.
GeneCardsiGC17P015602.
HGNCiHGNC:13501. ZNF286A.
neXtProtiNX_Q9HBT8.
PharmGKBiPA162410066.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119202.
ENSGT00770000120517.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9HBT8.
KOiK09228.
OMAiFHTLEKR.
PhylomeDBiQ9HBT8.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii57335.
NextBioi35472776.
PROiQ9HBT8.

Gene expression databases

BgeeiQ9HBT8.
CleanExiHS_ZNF286A.
ExpressionAtlasiQ9HBT8. baseline and differential.
GenevisibleiQ9HBT8. HS.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Deletion of a novel zinc finger gene in Smith-Magenis syndrome."
    Romero-Pastrana F., Srivastava A.K.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-90.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thalamus.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO N-TERMINUS.

Entry informationi

Entry nameiZ286A_HUMAN
AccessioniPrimary (citable) accession number: Q9HBT8
Secondary accession number(s): B4DKF9, Q96JF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.