Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9HBT8

- Z286A_HUMAN

UniProt

Q9HBT8 - Z286A_HUMAN

Protein

Zinc finger protein 286A

Gene

ZNF286A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri243 – 26523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri298 – 32023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri326 – 34823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri354 – 37623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri382 – 40423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri410 – 43223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri438 – 46023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri466 – 48823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri494 – 51623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 286A
    Gene namesi
    Name:ZNF286A
    Synonyms:KIAA1874, ZNF286
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:13501. ZNF286A.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410066.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Zinc finger protein 286APRO_0000047510Add
    BLAST

    Proteomic databases

    MaxQBiQ9HBT8.
    PaxDbiQ9HBT8.
    PRIDEiQ9HBT8.

    PTM databases

    PhosphoSiteiQ9HBT8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9HBT8.
    BgeeiQ9HBT8.
    CleanExiHS_ZNF286A.
    GenevestigatoriQ9HBT8.

    Interactioni

    Protein-protein interaction databases

    BioGridi121489. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HBT8.
    SMRiQ9HBT8. Positions 179-521.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 11167KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri243 – 26523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri298 – 32023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri326 – 34823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri354 – 37623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri382 – 40423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri410 – 43223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri438 – 46023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri466 – 48823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri494 – 51623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9HBT8.
    KOiK09228.
    OMAiVSKPENY.
    PhylomeDBiQ9HBT8.

    Family and domain databases

    Gene3Di3.30.160.60. 10 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HBT8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METDLAEMPE KGALSSQDSP HFQEKSTEEG EVAALRLTAR SQETVTFKDV    50
    AMDFTPEEWG KLDPAQRDVM LENYRNLVSL WLPVSKPESY NLENGKEPLK 100
    LERKAPKSSY SDMETRPQSK DSTSVQDFSK AESCKVAIID RLTRNSVYDS 150
    NLEAALECEN WLENQQGNQE RHLREMFTHM NSLSEETDHK HDVYWKSFNQ 200
    KSVLITEDRV PKGSYAFHTL EKSLKQKSNL MKKQRTYKEK KPHKCNDCGE 250
    LFTYHSVLIR HQRVHTGEKP YTCNECGKSF SHRANLTKHQ RTHTRILFEC 300
    SECKKTFTES SSLATHQRIH VGERPYECNE CGKGFNRSTH LVQHQLIHTG 350
    VKPYECNECD KAFIHSSALI KHQRTHTGEK PYKCQECGKA FSHCSSLTKH 400
    QRVHTGEKPY ECSECGKTFS QSTHLVQHQR IHTGEKPYEC NECGKTFSRS 450
    SNFAKHQRIH IGKKPYKCSE CGKAFIHSSA LIQHQRTHTG EKPFRCNECG 500
    KSFKCSSSLI RHQRVHTEEQ P 521
    Length:521
    Mass (Da):60,175
    Last modified:March 1, 2001 - v1
    Checksum:i485C3FF3DD210DBB
    GO
    Isoform 2 (identifier: Q9HBT8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: METDLAEMPEK → M

    Note: No experimental confirmation available.

    Show »
    Length:511
    Mass (Da):59,030
    Checksum:i2F65FAD9386E8F75
    GO

    Sequence cautioni

    The sequence BAB47503.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti90 – 901Y → H.1 Publication
    Corresponds to variant rs3760299 [ dbSNP | Ensembl ].
    VAR_021892

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1111METDLAEMPEK → M in isoform 2. 1 PublicationVSP_056673Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF217226 mRNA. Translation: AAG09701.1.
    AB058777 mRNA. Translation: BAB47503.2. Different initiation.
    AK296547 mRNA. Translation: BAG59171.1.
    AC005324 Genomic DNA. No translation available.
    CCDSiCCDS11172.1.
    RefSeqiNP_001124314.1. NM_001130842.1.
    NP_001275571.1. NM_001288642.1.
    NP_001275572.1. NM_001288643.1.
    NP_001275573.1. NM_001288644.1.
    NP_001275574.1. NM_001288645.1.
    NP_001275575.1. NM_001288646.1.
    NP_001275576.1. NM_001288647.1.
    NP_001275577.1. NM_001288648.1.
    NP_001275578.1. NM_001288649.1.
    NP_065703.1. NM_020652.2.
    UniGeneiHs.585799.
    Hs.659318.

    Genome annotation databases

    EnsembliENST00000412988; ENSP00000408168; ENSG00000255104.
    ENST00000421016; ENSP00000397163; ENSG00000187607.
    ENST00000464847; ENSP00000464218; ENSG00000187607.
    ENST00000583566; ENSP00000464063; ENSG00000187607.
    GeneIDi57335.
    KEGGihsa:57335.
    UCSCiuc002goz.4. human.

    Polymorphism databases

    DMDMi20141039.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF217226 mRNA. Translation: AAG09701.1 .
    AB058777 mRNA. Translation: BAB47503.2 . Different initiation.
    AK296547 mRNA. Translation: BAG59171.1 .
    AC005324 Genomic DNA. No translation available.
    CCDSi CCDS11172.1.
    RefSeqi NP_001124314.1. NM_001130842.1.
    NP_001275571.1. NM_001288642.1.
    NP_001275572.1. NM_001288643.1.
    NP_001275573.1. NM_001288644.1.
    NP_001275574.1. NM_001288645.1.
    NP_001275575.1. NM_001288646.1.
    NP_001275576.1. NM_001288647.1.
    NP_001275577.1. NM_001288648.1.
    NP_001275578.1. NM_001288649.1.
    NP_065703.1. NM_020652.2.
    UniGenei Hs.585799.
    Hs.659318.

    3D structure databases

    ProteinModelPortali Q9HBT8.
    SMRi Q9HBT8. Positions 179-521.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121489. 1 interaction.

    PTM databases

    PhosphoSitei Q9HBT8.

    Polymorphism databases

    DMDMi 20141039.

    Proteomic databases

    MaxQBi Q9HBT8.
    PaxDbi Q9HBT8.
    PRIDEi Q9HBT8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000412988 ; ENSP00000408168 ; ENSG00000255104 .
    ENST00000421016 ; ENSP00000397163 ; ENSG00000187607 .
    ENST00000464847 ; ENSP00000464218 ; ENSG00000187607 .
    ENST00000583566 ; ENSP00000464063 ; ENSG00000187607 .
    GeneIDi 57335.
    KEGGi hsa:57335.
    UCSCi uc002goz.4. human.

    Organism-specific databases

    CTDi 57335.
    GeneCardsi GC17P015602.
    GC17P015604.
    HGNCi HGNC:13501. ZNF286A.
    neXtProti NX_Q9HBT8.
    PharmGKBi PA162410066.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9HBT8.
    KOi K09228.
    OMAi VSKPENY.
    PhylomeDBi Q9HBT8.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 57335.
    NextBioi 63446.
    PROi Q9HBT8.

    Gene expression databases

    ArrayExpressi Q9HBT8.
    Bgeei Q9HBT8.
    CleanExi HS_ZNF286A.
    Genevestigatori Q9HBT8.

    Family and domain databases

    Gene3Di 3.30.160.60. 10 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Deletion of a novel zinc finger gene in Smith-Magenis syndrome."
      Romero-Pastrana F., Srivastava A.K.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-90.
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Thalamus.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO N-TERMINUS.

    Entry informationi

    Entry nameiZ286A_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBT8
    Secondary accession number(s): B4DKF9, Q96JF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3