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Q9HBT8

- Z286A_HUMAN

UniProt

Q9HBT8 - Z286A_HUMAN

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Protein

Zinc finger protein 286A

Gene

ZNF286A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri243 – 26523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 286A
Gene namesi
Name:ZNF286A
Synonyms:KIAA1874, ZNF286
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:13501. ZNF286A.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Zinc finger protein 286APRO_0000047510Add
BLAST

Proteomic databases

MaxQBiQ9HBT8.
PaxDbiQ9HBT8.
PRIDEiQ9HBT8.

PTM databases

PhosphoSiteiQ9HBT8.

Expressioni

Gene expression databases

BgeeiQ9HBT8.
CleanExiHS_ZNF286A.
ExpressionAtlasiQ9HBT8. baseline.
GenevestigatoriQ9HBT8.

Interactioni

Protein-protein interaction databases

BioGridi121489. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9HBT8.
SMRiQ9HBT8. Positions 179-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 11167KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri243 – 26523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri382 – 40423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119080.
ENSGT00760000119202.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9HBT8.
KOiK09228.
OMAiVSKPENY.
PhylomeDBiQ9HBT8.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HBT8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METDLAEMPE KGALSSQDSP HFQEKSTEEG EVAALRLTAR SQETVTFKDV
60 70 80 90 100
AMDFTPEEWG KLDPAQRDVM LENYRNLVSL WLPVSKPESY NLENGKEPLK
110 120 130 140 150
LERKAPKSSY SDMETRPQSK DSTSVQDFSK AESCKVAIID RLTRNSVYDS
160 170 180 190 200
NLEAALECEN WLENQQGNQE RHLREMFTHM NSLSEETDHK HDVYWKSFNQ
210 220 230 240 250
KSVLITEDRV PKGSYAFHTL EKSLKQKSNL MKKQRTYKEK KPHKCNDCGE
260 270 280 290 300
LFTYHSVLIR HQRVHTGEKP YTCNECGKSF SHRANLTKHQ RTHTRILFEC
310 320 330 340 350
SECKKTFTES SSLATHQRIH VGERPYECNE CGKGFNRSTH LVQHQLIHTG
360 370 380 390 400
VKPYECNECD KAFIHSSALI KHQRTHTGEK PYKCQECGKA FSHCSSLTKH
410 420 430 440 450
QRVHTGEKPY ECSECGKTFS QSTHLVQHQR IHTGEKPYEC NECGKTFSRS
460 470 480 490 500
SNFAKHQRIH IGKKPYKCSE CGKAFIHSSA LIQHQRTHTG EKPFRCNECG
510 520
KSFKCSSSLI RHQRVHTEEQ P
Length:521
Mass (Da):60,175
Last modified:March 1, 2001 - v1
Checksum:i485C3FF3DD210DBB
GO
Isoform 2 (identifier: Q9HBT8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: METDLAEMPEK → M

Note: No experimental confirmation available.

Show »
Length:511
Mass (Da):59,030
Checksum:i2F65FAD9386E8F75
GO

Sequence cautioni

The sequence BAB47503.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901Y → H.1 Publication
Corresponds to variant rs3760299 [ dbSNP | Ensembl ].
VAR_021892

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1111METDLAEMPEK → M in isoform 2. 1 PublicationVSP_056673Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF217226 mRNA. Translation: AAG09701.1.
AB058777 mRNA. Translation: BAB47503.2. Different initiation.
AK296547 mRNA. Translation: BAG59171.1.
AC005324 Genomic DNA. No translation available.
CCDSiCCDS11172.1. [Q9HBT8-1]
RefSeqiNP_001124314.1. NM_001130842.1.
NP_001275571.1. NM_001288642.1.
NP_001275572.1. NM_001288643.1.
NP_001275573.1. NM_001288644.1.
NP_001275574.1. NM_001288645.1.
NP_001275575.1. NM_001288646.1.
NP_001275576.1. NM_001288647.1.
NP_001275577.1. NM_001288648.1.
NP_001275578.1. NM_001288649.1.
NP_065703.1. NM_020652.2.
UniGeneiHs.585799.
Hs.659318.

Genome annotation databases

EnsembliENST00000421016; ENSP00000397163; ENSG00000187607. [Q9HBT8-1]
ENST00000464847; ENSP00000464218; ENSG00000187607. [Q9HBT8-1]
ENST00000583566; ENSP00000464063; ENSG00000187607. [Q9HBT8-1]
ENST00000593105; ENSP00000466154; ENSG00000187607. [Q9HBT8-2]
GeneIDi57335.
KEGGihsa:57335.
UCSCiuc002goz.4. human. [Q9HBT8-1]

Polymorphism databases

DMDMi20141039.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF217226 mRNA. Translation: AAG09701.1 .
AB058777 mRNA. Translation: BAB47503.2 . Different initiation.
AK296547 mRNA. Translation: BAG59171.1 .
AC005324 Genomic DNA. No translation available.
CCDSi CCDS11172.1. [Q9HBT8-1 ]
RefSeqi NP_001124314.1. NM_001130842.1.
NP_001275571.1. NM_001288642.1.
NP_001275572.1. NM_001288643.1.
NP_001275573.1. NM_001288644.1.
NP_001275574.1. NM_001288645.1.
NP_001275575.1. NM_001288646.1.
NP_001275576.1. NM_001288647.1.
NP_001275577.1. NM_001288648.1.
NP_001275578.1. NM_001288649.1.
NP_065703.1. NM_020652.2.
UniGenei Hs.585799.
Hs.659318.

3D structure databases

ProteinModelPortali Q9HBT8.
SMRi Q9HBT8. Positions 179-521.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121489. 1 interaction.

PTM databases

PhosphoSitei Q9HBT8.

Polymorphism databases

DMDMi 20141039.

Proteomic databases

MaxQBi Q9HBT8.
PaxDbi Q9HBT8.
PRIDEi Q9HBT8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000421016 ; ENSP00000397163 ; ENSG00000187607 . [Q9HBT8-1 ]
ENST00000464847 ; ENSP00000464218 ; ENSG00000187607 . [Q9HBT8-1 ]
ENST00000583566 ; ENSP00000464063 ; ENSG00000187607 . [Q9HBT8-1 ]
ENST00000593105 ; ENSP00000466154 ; ENSG00000187607 . [Q9HBT8-2 ]
GeneIDi 57335.
KEGGi hsa:57335.
UCSCi uc002goz.4. human. [Q9HBT8-1 ]

Organism-specific databases

CTDi 57335.
GeneCardsi GC17P015602.
HGNCi HGNC:13501. ZNF286A.
neXtProti NX_Q9HBT8.
PharmGKBi PA162410066.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119080.
ENSGT00760000119202.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9HBT8.
KOi K09228.
OMAi VSKPENY.
PhylomeDBi Q9HBT8.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 57335.
NextBioi 35472776.
PROi Q9HBT8.

Gene expression databases

Bgeei Q9HBT8.
CleanExi HS_ZNF286A.
ExpressionAtlasi Q9HBT8. baseline.
Genevestigatori Q9HBT8.

Family and domain databases

Gene3Di 3.30.160.60. 10 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Deletion of a novel zinc finger gene in Smith-Magenis syndrome."
    Romero-Pastrana F., Srivastava A.K.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-90.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thalamus.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO N-TERMINUS.

Entry informationi

Entry nameiZ286A_HUMAN
AccessioniPrimary (citable) accession number: Q9HBT8
Secondary accession number(s): B4DKF9, Q96JF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3