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Protein

Zinc finger protein 287

Gene

ZNF287

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri361 – 38323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 43923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri473 – 49523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri501 – 52323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri529 – 55123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri557 – 57923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri585 – 60723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri613 – 63523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri641 – 66323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri669 – 69123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri697 – 71923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri725 – 74723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 287
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 13
Gene namesi
Name:ZNF287
Synonyms:ZKSCAN13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:13502. ZNF287.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37788.

Polymorphism and mutation databases

BioMutaiZNF287.
DMDMi20141038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754Zinc finger protein 287PRO_0000047511Add
BLAST

Proteomic databases

PaxDbiQ9HBT7.
PRIDEiQ9HBT7.

PTM databases

PhosphoSiteiQ9HBT7.

Expressioni

Gene expression databases

BgeeiQ9HBT7.
CleanExiHS_ZNF287.
ExpressionAtlasiQ9HBT7. baseline and differential.
GenevisibleiQ9HBT7. HS.

Organism-specific databases

HPAiHPA029290.

Interactioni

Protein-protein interaction databases

IntActiQ9HBT7. 1 interaction.
STRINGi9606.ENSP00000379168.

Structurei

3D structure databases

ProteinModelPortaliQ9HBT7.
SMRiQ9HBT7. Positions 37-125, 313-751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 12483SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini163 – 23169KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri361 – 38323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 43923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri473 – 49523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri501 – 52323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri529 – 55123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri557 – 57923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri585 – 60723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri613 – 63523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri641 – 66323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri669 – 69123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri697 – 71923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri725 – 74723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9HBT7.
KOiK09229.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9HBT7.
TreeFamiTF350843.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HBT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSSRSQIL LRWKSDKAQS GPYNVEKEIL TSRFLRDTET CRQNFRNFPY
60 70 80 90 100
PDLAGPRKAL SQLRELCLKW LRPEIHSKEQ ILELLVLEQF LTILPGEVRT
110 120 130 140 150
WVKSQYPESS EEAVTLVEDL TQILEEEAPQ NSTLSQDTPE EDPRGKHAFQ
160 170 180 190 200
TGWLNDLVTK ESMTFKDVAV DITQEDWELM RPVQKELYKT VTLQNYWNMV
210 220 230 240 250
SLGLTVYRPT VIPILEEPWM VIKEILEGPS PEWETKAQAC TPVEDMSKLT
260 270 280 290 300
KEETHTIKLE DSYDYDDRLE RRGKGGFWKI HTDERGFSLK SVLSQEYDPT
310 320 330 340 350
EECLSKYDIY RNNFEKHSNL IVQFDTQLDN KTSVYNEGRA TFNHVSYGIV
360 370 380 390 400
HRKILPGEKP YKCNVCGKKF RKYPSLLKHQ STHAKEKSYE CEECGKEFRH
410 420 430 440 450
ISSLIAHQRM HTGEKPYECH QCGKAFSQRA HLTIHQRIHT GEKPYKCDDC
460 470 480 490 500
GKDFSQRAHL TIHQRTHTGE KPYKCLECGK TFSHSSSLIN HQRVHTGEKP
510 520 530 540 550
YICNECGKTF SQSTHLLQHQ KIHTGKKPYK CNECWKVFSQ STYLIRHQRI
560 570 580 590 600
HSGEKCYKCN ECGKAFAHSS TLIQHQTTHT GEKSYICNIC GKAFSQSANL
610 620 630 640 650
TQHHRTHTGE KPYKCSVCGK AFSQSVHLTQ HQRIHNGEKP FKCNICGKAY
660 670 680 690 700
RQGANLTQHQ RIHTGEKPYK CNECGKAFIY SSSLNQHQRT HTGERPYKCN
710 720 730 740 750
ECDKDFSQRT CLIQHQRIHT GEKPYACRIC GKTFTQSTNL IQHQRVHTGA

KHRN
Length:754
Mass (Da):87,565
Last modified:March 1, 2001 - v1
Checksum:iA1CCF1F5180601C5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti274 – 2741K → T.
Corresponds to variant rs7224723 [ dbSNP | Ensembl ].
VAR_024207

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217227 mRNA. Translation: AAG09702.1.
CR457194 mRNA. Translation: CAG33475.1.
AC127540 Genomic DNA. No translation available.
BC101487 mRNA. Translation: AAI01488.1.
BC113363 mRNA. Translation: AAI13364.1.
RefSeqiNP_065704.2. NM_020653.2.
UniGeneiHs.99724.

Genome annotation databases

EnsembliENST00000395824; ENSP00000379168; ENSG00000141040.
ENST00000395825; ENSP00000379169; ENSG00000141040.
GeneIDi57336.
KEGGihsa:57336.
UCSCiuc002gqi.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217227 mRNA. Translation: AAG09702.1.
CR457194 mRNA. Translation: CAG33475.1.
AC127540 Genomic DNA. No translation available.
BC101487 mRNA. Translation: AAI01488.1.
BC113363 mRNA. Translation: AAI13364.1.
RefSeqiNP_065704.2. NM_020653.2.
UniGeneiHs.99724.

3D structure databases

ProteinModelPortaliQ9HBT7.
SMRiQ9HBT7. Positions 37-125, 313-751.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9HBT7. 1 interaction.
STRINGi9606.ENSP00000379168.

PTM databases

PhosphoSiteiQ9HBT7.

Polymorphism and mutation databases

BioMutaiZNF287.
DMDMi20141038.

Proteomic databases

PaxDbiQ9HBT7.
PRIDEiQ9HBT7.

Protocols and materials databases

DNASUi57336.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395824; ENSP00000379168; ENSG00000141040.
ENST00000395825; ENSP00000379169; ENSG00000141040.
GeneIDi57336.
KEGGihsa:57336.
UCSCiuc002gqi.2. human.

Organism-specific databases

CTDi57336.
GeneCardsiGC17M016453.
HGNCiHGNC:13502. ZNF287.
HPAiHPA029290.
neXtProtiNX_Q9HBT7.
PharmGKBiPA37788.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9HBT7.
KOiK09229.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9HBT7.
TreeFamiTF350843.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii57336.
NextBioi63450.
PROiQ9HBT7.

Gene expression databases

BgeeiQ9HBT7.
CleanExiHS_ZNF287.
ExpressionAtlasiQ9HBT7. baseline and differential.
GenevisibleiQ9HBT7. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Deletion of a novel zinc finger gene in Smith-Magenis syndrome."
    Romero-Pastrana F., Srivastava A.K.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZN287_HUMAN
AccessioniPrimary (citable) accession number: Q9HBT7
Secondary accession number(s): Q6IAG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.