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Q9HBT7 (ZN287_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 287
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 13
Gene names
Name:ZNF287
Synonyms:ZKSCAN13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length754 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 14 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Contains 1 SCAN box domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 754754Zinc finger protein 287
PRO_0000047511

Regions

Domain42 – 12483SCAN box
Domain163 – 23169KRAB
Zinc finger361 – 38323C2H2-type 1
Zinc finger389 – 41123C2H2-type 2
Zinc finger417 – 43923C2H2-type 3
Zinc finger445 – 46723C2H2-type 4
Zinc finger473 – 49523C2H2-type 5
Zinc finger501 – 52323C2H2-type 6
Zinc finger529 – 55123C2H2-type 7
Zinc finger557 – 57923C2H2-type 8
Zinc finger585 – 60723C2H2-type 9
Zinc finger613 – 63523C2H2-type 10
Zinc finger641 – 66323C2H2-type 11
Zinc finger669 – 69123C2H2-type 12
Zinc finger697 – 71923C2H2-type 13
Zinc finger725 – 74723C2H2-type 14

Natural variations

Natural variant2741K → T.
Corresponds to variant rs7224723 [ dbSNP | Ensembl ].
VAR_024207

Sequences

Sequence LengthMass (Da)Tools
Q9HBT7 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: A1CCF1F5180601C5

FASTA75487,565
        10         20         30         40         50         60 
MNSSSRSQIL LRWKSDKAQS GPYNVEKEIL TSRFLRDTET CRQNFRNFPY PDLAGPRKAL 

        70         80         90        100        110        120 
SQLRELCLKW LRPEIHSKEQ ILELLVLEQF LTILPGEVRT WVKSQYPESS EEAVTLVEDL 

       130        140        150        160        170        180 
TQILEEEAPQ NSTLSQDTPE EDPRGKHAFQ TGWLNDLVTK ESMTFKDVAV DITQEDWELM 

       190        200        210        220        230        240 
RPVQKELYKT VTLQNYWNMV SLGLTVYRPT VIPILEEPWM VIKEILEGPS PEWETKAQAC 

       250        260        270        280        290        300 
TPVEDMSKLT KEETHTIKLE DSYDYDDRLE RRGKGGFWKI HTDERGFSLK SVLSQEYDPT 

       310        320        330        340        350        360 
EECLSKYDIY RNNFEKHSNL IVQFDTQLDN KTSVYNEGRA TFNHVSYGIV HRKILPGEKP 

       370        380        390        400        410        420 
YKCNVCGKKF RKYPSLLKHQ STHAKEKSYE CEECGKEFRH ISSLIAHQRM HTGEKPYECH 

       430        440        450        460        470        480 
QCGKAFSQRA HLTIHQRIHT GEKPYKCDDC GKDFSQRAHL TIHQRTHTGE KPYKCLECGK 

       490        500        510        520        530        540 
TFSHSSSLIN HQRVHTGEKP YICNECGKTF SQSTHLLQHQ KIHTGKKPYK CNECWKVFSQ 

       550        560        570        580        590        600 
STYLIRHQRI HSGEKCYKCN ECGKAFAHSS TLIQHQTTHT GEKSYICNIC GKAFSQSANL 

       610        620        630        640        650        660 
TQHHRTHTGE KPYKCSVCGK AFSQSVHLTQ HQRIHNGEKP FKCNICGKAY RQGANLTQHQ 

       670        680        690        700        710        720 
RIHTGEKPYK CNECGKAFIY SSSLNQHQRT HTGERPYKCN ECDKDFSQRT CLIQHQRIHT 

       730        740        750 
GEKPYACRIC GKTFTQSTNL IQHQRVHTGA KHRN 

« Hide

References

« Hide 'large scale' references
[1]"Deletion of a novel zinc finger gene in Smith-Magenis syndrome."
Romero-Pastrana F., Srivastava A.K.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF217227 mRNA. Translation: AAG09702.1.
CR457194 mRNA. Translation: CAG33475.1.
AC127540 Genomic DNA. No translation available.
BC101487 mRNA. Translation: AAI01488.1.
BC113363 mRNA. Translation: AAI13364.1.
RefSeqNP_065704.2. NM_020653.2.
UniGeneHs.99724.

3D structure databases

ProteinModelPortalQ9HBT7.
SMRQ9HBT7. Positions 37-125, 313-751.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121490. 2 interactions.
IntActQ9HBT7. 1 interaction.

PTM databases

PhosphoSiteQ9HBT7.

Polymorphism databases

DMDM20141038.

Proteomic databases

PaxDbQ9HBT7.
PRIDEQ9HBT7.

Protocols and materials databases

DNASU57336.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000395824; ENSP00000379168; ENSG00000141040.
ENST00000395825; ENSP00000379169; ENSG00000141040.
GeneID57336.
KEGGhsa:57336.
UCSCuc002gqi.2. human.

Organism-specific databases

CTD57336.
GeneCardsGC17M016453.
HGNCHGNC:13502. ZNF287.
HPAHPA029290.
neXtProtNX_Q9HBT7.
PharmGKBPA37788.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ9HBT7.
KOK09229.
OrthoDBEOG7KSX7Q.
PhylomeDBQ9HBT7.
TreeFamTF350843.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9HBT7.
BgeeQ9HBT7.
CleanExHS_ZNF287.
GenevestigatorQ9HBT7.

Family and domain databases

Gene3D3.30.160.60. 14 hits.
InterProIPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi57336.
NextBio63450.
PROQ9HBT7.

Entry information

Entry nameZN287_HUMAN
AccessionPrimary (citable) accession number: Q9HBT7
Secondary accession number(s): Q6IAG1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: June 11, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM