Q9HBT7 (ZN287_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 287

Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 13

Gene names

Name:	ZNF287
Synonyms:	ZKSCAN13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	754 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 14 C2H2-type zinc fingers. Contains 1 KRAB domain. Contains 1 SCAN box domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara regulation of cytokine biosynthetic process Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 754	754	Zinc finger protein 287		PRO_0000047511
Regions
	Domain	42 – 124	83	SCAN box
	Domain	163 – 231	69	KRAB
	Zinc finger	361 – 383	23	C2H2-type 1
	Zinc finger	389 – 411	23	C2H2-type 2
	Zinc finger	417 – 439	23	C2H2-type 3
	Zinc finger	445 – 467	23	C2H2-type 4
	Zinc finger	473 – 495	23	C2H2-type 5
	Zinc finger	501 – 523	23	C2H2-type 6
	Zinc finger	529 – 551	23	C2H2-type 7
	Zinc finger	557 – 579	23	C2H2-type 8
	Zinc finger	585 – 607	23	C2H2-type 9
	Zinc finger	613 – 635	23	C2H2-type 10
	Zinc finger	641 – 663	23	C2H2-type 11
	Zinc finger	669 – 691	23	C2H2-type 12
	Zinc finger	697 – 719	23	C2H2-type 13
	Zinc finger	725 – 747	23	C2H2-type 14
Natural variations
	Natural variant	274	1	K → T. Corresponds to variant rs7224723 [ dbSNP | Ensembl ].		VAR_024207

Sequences

	Sequence		Length	Mass (Da)
	Q9HBT7 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: A1CCF1F5180601C5	FASTA	754	87,565
	10 20 30 40 50 60 MNSSSRSQIL LRWKSDKAQS GPYNVEKEIL TSRFLRDTET CRQNFRNFPY PDLAGPRKAL 70 80 90 100 110 120 SQLRELCLKW LRPEIHSKEQ ILELLVLEQF LTILPGEVRT WVKSQYPESS EEAVTLVEDL 130 140 150 160 170 180 TQILEEEAPQ NSTLSQDTPE EDPRGKHAFQ TGWLNDLVTK ESMTFKDVAV DITQEDWELM 190 200 210 220 230 240 RPVQKELYKT VTLQNYWNMV SLGLTVYRPT VIPILEEPWM VIKEILEGPS PEWETKAQAC 250 260 270 280 290 300 TPVEDMSKLT KEETHTIKLE DSYDYDDRLE RRGKGGFWKI HTDERGFSLK SVLSQEYDPT 310 320 330 340 350 360 EECLSKYDIY RNNFEKHSNL IVQFDTQLDN KTSVYNEGRA TFNHVSYGIV HRKILPGEKP 370 380 390 400 410 420 YKCNVCGKKF RKYPSLLKHQ STHAKEKSYE CEECGKEFRH ISSLIAHQRM HTGEKPYECH 430 440 450 460 470 480 QCGKAFSQRA HLTIHQRIHT GEKPYKCDDC GKDFSQRAHL TIHQRTHTGE KPYKCLECGK 490 500 510 520 530 540 TFSHSSSLIN HQRVHTGEKP YICNECGKTF SQSTHLLQHQ KIHTGKKPYK CNECWKVFSQ 550 560 570 580 590 600 STYLIRHQRI HSGEKCYKCN ECGKAFAHSS TLIQHQTTHT GEKSYICNIC GKAFSQSANL 610 620 630 640 650 660 TQHHRTHTGE KPYKCSVCGK AFSQSVHLTQ HQRIHNGEKP FKCNICGKAY RQGANLTQHQ 670 680 690 700 710 720 RIHTGEKPYK CNECGKAFIY SSSLNQHQRT HTGERPYKCN ECDKDFSQRT CLIQHQRIHT 730 740 750 GEKPYACRIC GKTFTQSTNL IQHQRVHTGA KHRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deletion of a novel zinc finger gene in Smith-Magenis syndrome." Romero-Pastrana F., Srivastava A.K. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF217227 mRNA. Translation: AAG09702.1. CR457194 mRNA. Translation: CAG33475.1. AC127540 Genomic DNA. No translation available. BC101487 mRNA. Translation: AAI01488.1. BC113363 mRNA. Translation: AAI13364.1.
IPI	IPI00010165.
RefSeq	NP_065704.2. NM_020653.2.
UniGene	Hs.99724.
3D structure databases
ProteinModelPortal	Q9HBT7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HBT7. 1 interaction.
PTM databases
PhosphoSite	Q9HBT7.
Polymorphism databases
DMDM	20141038.
Proteomic databases
PaxDb	Q9HBT7.
PRIDE	Q9HBT7.
Protocols and materials databases
DNASU	57336.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000395824; ENSP00000379168; ENSG00000141040. ENST00000395825; ENSP00000379169; ENSG00000141040.
GeneID	57336.
KEGG	hsa:57336.
UCSC	uc002gqi.2. human.
Organism-specific databases
CTD	57336.
GeneCards	GC17M016453.
HGNC	HGNC:13502. ZNF287.
HPA	HPA029290.
neXtProt	NX_Q9HBT7.
PharmGKB	PA37788.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q9HBT7.
KO	K09229.
OrthoDB	EOG4WQ11W.
PhylomeDB	Q9HBT7.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q9HBT7.
Bgee	Q9HBT7.
CleanEx	HS_ZNF287.
Genevestigator	Q9HBT7.
GermOnline	ENSG00000141040. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 14 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR008916. Retrov_capsid_C. IPR003309. Tscrpt_reg_SCAN. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF02023. SCAN. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00431. SCAN. 1 hit. SM00355. ZnF_C2H2. 14 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit. SSF47353. Retrov_capsid_C. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS50804. SCAN_BOX. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 14 hits. PS50157. ZINC_FINGER_C2H2_2. 14 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57336.
NextBio	63450.

Entry information

Entry name

ZN287_HUMAN

Accession

Primary (citable) accession number: Q9HBT7
Secondary accession number(s): Q6IAG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.