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Q9HBT7

- ZN287_HUMAN

UniProt

Q9HBT7 - ZN287_HUMAN

Protein

Zinc finger protein 287

Gene

ZNF287

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri361 – 38323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri389 – 41123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri417 – 43923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri445 – 46723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri473 – 49523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri501 – 52323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri529 – 55123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri557 – 57923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri585 – 60723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri613 – 63523C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri641 – 66323C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri669 – 69123C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri697 – 71923C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri725 – 74723C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: Ensembl
    2. regulation of cytokine biosynthetic process Source: Ensembl
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 287
    Alternative name(s):
    Zinc finger protein with KRAB and SCAN domains 13
    Gene namesi
    Name:ZNF287
    Synonyms:ZKSCAN13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:13502. ZNF287.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37788.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 754754Zinc finger protein 287PRO_0000047511Add
    BLAST

    Proteomic databases

    PaxDbiQ9HBT7.
    PRIDEiQ9HBT7.

    PTM databases

    PhosphoSiteiQ9HBT7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9HBT7.
    BgeeiQ9HBT7.
    CleanExiHS_ZNF287.
    GenevestigatoriQ9HBT7.

    Organism-specific databases

    HPAiHPA029290.

    Interactioni

    Protein-protein interaction databases

    BioGridi121490. 2 interactions.
    IntActiQ9HBT7. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HBT7.
    SMRiQ9HBT7. Positions 37-125, 313-751.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 12483SCAN boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini163 – 23169KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri361 – 38323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri389 – 41123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri417 – 43923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri445 – 46723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri473 – 49523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri501 – 52323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri529 – 55123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri557 – 57923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri585 – 60723C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri613 – 63523C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri641 – 66323C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri669 – 69123C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri697 – 71923C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri725 – 74723C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9HBT7.
    KOiK09229.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9HBT7.
    TreeFamiTF350843.

    Family and domain databases

    Gene3Di3.30.160.60. 14 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF02023. SCAN. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 14 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    SSF47353. SSF47353. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 14 hits.
    PS50157. ZINC_FINGER_C2H2_2. 14 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HBT7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSSSRSQIL LRWKSDKAQS GPYNVEKEIL TSRFLRDTET CRQNFRNFPY    50
    PDLAGPRKAL SQLRELCLKW LRPEIHSKEQ ILELLVLEQF LTILPGEVRT 100
    WVKSQYPESS EEAVTLVEDL TQILEEEAPQ NSTLSQDTPE EDPRGKHAFQ 150
    TGWLNDLVTK ESMTFKDVAV DITQEDWELM RPVQKELYKT VTLQNYWNMV 200
    SLGLTVYRPT VIPILEEPWM VIKEILEGPS PEWETKAQAC TPVEDMSKLT 250
    KEETHTIKLE DSYDYDDRLE RRGKGGFWKI HTDERGFSLK SVLSQEYDPT 300
    EECLSKYDIY RNNFEKHSNL IVQFDTQLDN KTSVYNEGRA TFNHVSYGIV 350
    HRKILPGEKP YKCNVCGKKF RKYPSLLKHQ STHAKEKSYE CEECGKEFRH 400
    ISSLIAHQRM HTGEKPYECH QCGKAFSQRA HLTIHQRIHT GEKPYKCDDC 450
    GKDFSQRAHL TIHQRTHTGE KPYKCLECGK TFSHSSSLIN HQRVHTGEKP 500
    YICNECGKTF SQSTHLLQHQ KIHTGKKPYK CNECWKVFSQ STYLIRHQRI 550
    HSGEKCYKCN ECGKAFAHSS TLIQHQTTHT GEKSYICNIC GKAFSQSANL 600
    TQHHRTHTGE KPYKCSVCGK AFSQSVHLTQ HQRIHNGEKP FKCNICGKAY 650
    RQGANLTQHQ RIHTGEKPYK CNECGKAFIY SSSLNQHQRT HTGERPYKCN 700
    ECDKDFSQRT CLIQHQRIHT GEKPYACRIC GKTFTQSTNL IQHQRVHTGA 750
    KHRN 754
    Length:754
    Mass (Da):87,565
    Last modified:March 1, 2001 - v1
    Checksum:iA1CCF1F5180601C5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti274 – 2741K → T.
    Corresponds to variant rs7224723 [ dbSNP | Ensembl ].
    VAR_024207

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF217227 mRNA. Translation: AAG09702.1.
    CR457194 mRNA. Translation: CAG33475.1.
    AC127540 Genomic DNA. No translation available.
    BC101487 mRNA. Translation: AAI01488.1.
    BC113363 mRNA. Translation: AAI13364.1.
    RefSeqiNP_065704.2. NM_020653.2.
    UniGeneiHs.99724.

    Genome annotation databases

    EnsembliENST00000395824; ENSP00000379168; ENSG00000141040.
    ENST00000395825; ENSP00000379169; ENSG00000141040.
    GeneIDi57336.
    KEGGihsa:57336.
    UCSCiuc002gqi.2. human.

    Polymorphism databases

    DMDMi20141038.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF217227 mRNA. Translation: AAG09702.1 .
    CR457194 mRNA. Translation: CAG33475.1 .
    AC127540 Genomic DNA. No translation available.
    BC101487 mRNA. Translation: AAI01488.1 .
    BC113363 mRNA. Translation: AAI13364.1 .
    RefSeqi NP_065704.2. NM_020653.2.
    UniGenei Hs.99724.

    3D structure databases

    ProteinModelPortali Q9HBT7.
    SMRi Q9HBT7. Positions 37-125, 313-751.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121490. 2 interactions.
    IntActi Q9HBT7. 1 interaction.

    PTM databases

    PhosphoSitei Q9HBT7.

    Polymorphism databases

    DMDMi 20141038.

    Proteomic databases

    PaxDbi Q9HBT7.
    PRIDEi Q9HBT7.

    Protocols and materials databases

    DNASUi 57336.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395824 ; ENSP00000379168 ; ENSG00000141040 .
    ENST00000395825 ; ENSP00000379169 ; ENSG00000141040 .
    GeneIDi 57336.
    KEGGi hsa:57336.
    UCSCi uc002gqi.2. human.

    Organism-specific databases

    CTDi 57336.
    GeneCardsi GC17M016453.
    HGNCi HGNC:13502. ZNF287.
    HPAi HPA029290.
    neXtProti NX_Q9HBT7.
    PharmGKBi PA37788.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9HBT7.
    KOi K09229.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9HBT7.
    TreeFami TF350843.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 57336.
    NextBioi 63450.
    PROi Q9HBT7.

    Gene expression databases

    ArrayExpressi Q9HBT7.
    Bgeei Q9HBT7.
    CleanExi HS_ZNF287.
    Genevestigatori Q9HBT7.

    Family and domain databases

    Gene3Di 3.30.160.60. 14 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF02023. SCAN. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 14 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    SSF47353. SSF47353. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 14 hits.
    PS50157. ZINC_FINGER_C2H2_2. 14 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Deletion of a novel zinc finger gene in Smith-Magenis syndrome."
      Romero-Pastrana F., Srivastava A.K.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiZN287_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBT7
    Secondary accession number(s): Q6IAG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3