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Protein

Cadherin-20

Gene

CDH20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101542-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-20
Gene namesi
Name:CDH20
Synonyms:CDH7L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:1760. CDH20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini60 – 619ExtracellularSequence analysisAdd BLAST560
Transmembranei620 – 640HelicalSequence analysisAdd BLAST21
Topological domaini641 – 801CytoplasmicSequence analysisAdd BLAST161

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi28316.
OpenTargetsiENSG00000101542.
PharmGKBiPA26294.

Polymorphism and mutation databases

BioMutaiCDH20.
DMDMi190359622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
PropeptideiPRO_000000381935 – 59Sequence analysisAdd BLAST25
ChainiPRO_000000382060 – 801Cadherin-20Add BLAST742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi261N-linked (GlcNAc...)Sequence analysis1
Glycosylationi420N-linked (GlcNAc...)Sequence analysis1
Glycosylationi461N-linked (GlcNAc...)Sequence analysis1
Glycosylationi542N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiQ9HBT6.
PeptideAtlasiQ9HBT6.
PRIDEiQ9HBT6.

PTM databases

iPTMnetiQ9HBT6.
PhosphoSitePlusiQ9HBT6.

Expressioni

Tissue specificityi

Expressed in placenta, adult brain, and fetal brain.

Gene expression databases

BgeeiENSG00000101542.
CleanExiHS_CDH20.
GenevisibleiQ9HBT6. HS.

Organism-specific databases

HPAiHPA015490.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000262717.

Structurei

3D structure databases

ProteinModelPortaliQ9HBT6.
SMRiQ9HBT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 165Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini166 – 274Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini275 – 389Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini390 – 494Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini494 – 610Cadherin 5PROSITE-ProRule annotationAdd BLAST117

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9HBT6.
KOiK06807.
OMAiEERSQYT.
OrthoDBiEOG091G01U9.
PhylomeDBiQ9HBT6.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HBT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTSGRMSNA KNWLGLGMSL YFWGLMDLTT TVLSDTPTPQ GELEALLSDK
60 70 80 90 100
PQSHQRTKRS WVWNQFFVLE EYTGTDPLYV GKLHSDMDRG DGSIKYILSG
110 120 130 140 150
EGAGIVFTID DTTGDIHAIQ RLDREERAQY TLRAQALDRR TGRPMEPESE
160 170 180 190 200
FIIKIQDIND NEPKFLDGPY VATVPEMSPV GTSVIQVTAT DADDPTYGNS
210 220 230 240 250
ARVVYSILQG QPYFSVDSKT GVIRTALMNM DREAKEYYEV IIQAKDMGGQ
260 270 280 290 300
LGGLAGTTTV NITLSDVNDN PPRFPQKHYQ MSVLESAPIS STVGRVFAKD
310 320 330 340 350
LDEGINAEMK YTIVDGDGAD AFDISTDPNF QVGIITVKKP LSFESKKSYT
360 370 380 390 400
LKVEGANPHL EMRFLNLGPF QDTTTVHISV EDVDEPPVFE PGFYFVEVPE
410 420 430 440 450
DVAIGTTIQI ISAKDPDVTN NSIRYSIDRS SDPGRFFYVD ITTGALMTAR
460 470 480 490 500
PLDREEFSWH NITVLAMEMN NPSQVGSVPV TIKVLDVNDN APEFPRFYEA
510 520 530 540 550
FVCENAKAGQ LIQTVSAVDQ DDPRNGQHFY YSLAPEAANN PNFTIRDNQD
560 570 580 590 600
NTARILTRRS GFRQQEQSVF HLPILIADSG QPVLSSTGTL TIQVCSCDDD
610 620 630 640 650
GHVMSCSPEA YMLPVSLSRG ALIAILACIF VLLVLVLLIL SMRRHRKQPY
660 670 680 690 700
IIDDEENIHE NIVRYDDEGG GEEDTEAFDI AAMWNPREAQ AGAAPKTRQD
710 720 730 740 750
MLPEIESLSR YVPQTCAVNS TVHSYVLAKL YEADMDLWAP PFDSLQTYMF
760 770 780 790 800
EGDGSVAGSL SSLQSATSDS EQSFDFLTDW GPRFRKLAEL YGASEGPAPL

W
Length:801
Mass (Da):88,993
Last modified:February 26, 2008 - v2
Checksum:i6B8B226519F49C5E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti621A → P in AAG23739 (PubMed:10995570).Curated1
Sequence conflicti694A → G in AAG23739 (PubMed:10995570).Curated1
Sequence conflicti709S → F in AAG23739 (PubMed:10995570).Curated1
Sequence conflicti739A → T in AAG23739 (PubMed:10995570).Curated1
Sequence conflicti755S → P in AAG23739 (PubMed:10995570).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036103228M → I in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_039119328P → H.Corresponds to variant rs1943330dbSNPEnsembl.1
Natural variantiVAR_039120371Q → R.Corresponds to variant rs35923922dbSNPEnsembl.1
Natural variantiVAR_039121391P → L.Corresponds to variant rs17068463dbSNPEnsembl.1
Natural variantiVAR_036104416P → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036105746Q → H in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217289 mRNA. Translation: AAG23739.1.
CH471096 Genomic DNA. Translation: EAW63108.1.
BC101047 mRNA. Translation: AAI01048.1.
BC101048 mRNA. Translation: AAI01049.1.
BC101049 mRNA. Translation: AAI01050.1.
CCDSiCCDS11977.1.
RefSeqiNP_114097.2. NM_031891.3.
UniGeneiHs.671510.

Genome annotation databases

EnsembliENST00000262717; ENSP00000262717; ENSG00000101542.
ENST00000536675; ENSP00000444767; ENSG00000101542.
ENST00000538374; ENSP00000442226; ENSG00000101542.
GeneIDi28316.
KEGGihsa:28316.
UCSCiuc002lif.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217289 mRNA. Translation: AAG23739.1.
CH471096 Genomic DNA. Translation: EAW63108.1.
BC101047 mRNA. Translation: AAI01048.1.
BC101048 mRNA. Translation: AAI01049.1.
BC101049 mRNA. Translation: AAI01050.1.
CCDSiCCDS11977.1.
RefSeqiNP_114097.2. NM_031891.3.
UniGeneiHs.671510.

3D structure databases

ProteinModelPortaliQ9HBT6.
SMRiQ9HBT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000262717.

PTM databases

iPTMnetiQ9HBT6.
PhosphoSitePlusiQ9HBT6.

Polymorphism and mutation databases

BioMutaiCDH20.
DMDMi190359622.

Proteomic databases

PaxDbiQ9HBT6.
PeptideAtlasiQ9HBT6.
PRIDEiQ9HBT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262717; ENSP00000262717; ENSG00000101542.
ENST00000536675; ENSP00000444767; ENSG00000101542.
ENST00000538374; ENSP00000442226; ENSG00000101542.
GeneIDi28316.
KEGGihsa:28316.
UCSCiuc002lif.3. human.

Organism-specific databases

CTDi28316.
DisGeNETi28316.
GeneCardsiCDH20.
H-InvDBHIX0014487.
HGNCiHGNC:1760. CDH20.
HPAiHPA015490.
MIMi605807. gene.
neXtProtiNX_Q9HBT6.
OpenTargetsiENSG00000101542.
PharmGKBiPA26294.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9HBT6.
KOiK06807.
OMAiEERSQYT.
OrthoDBiEOG091G01U9.
PhylomeDBiQ9HBT6.
TreeFamiTF329887.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101542-MONOMER.

Miscellaneous databases

GenomeRNAii28316.
PROiQ9HBT6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101542.
CleanExiHS_CDH20.
GenevisibleiQ9HBT6. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD20_HUMAN
AccessioniPrimary (citable) accession number: Q9HBT6
Secondary accession number(s): Q495S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.