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Protein

Cadherin-20

Gene

CDH20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-20
Gene namesi
Name:CDH20
Synonyms:CDH7L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:1760. CDH20.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini60 – 619560ExtracellularSequence analysisAdd
BLAST
Transmembranei620 – 64021HelicalSequence analysisAdd
BLAST
Topological domaini641 – 801161CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26294.

Polymorphism and mutation databases

BioMutaiCDH20.
DMDMi190359622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence analysisAdd
BLAST
Propeptidei35 – 5925Sequence analysisPRO_0000003819Add
BLAST
Chaini60 – 801742Cadherin-20PRO_0000003820Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence analysis
Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence analysis
Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence analysis
Glycosylationi542 – 5421N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiQ9HBT6.
PRIDEiQ9HBT6.

PTM databases

iPTMnetiQ9HBT6.
PhosphoSiteiQ9HBT6.

Expressioni

Tissue specificityi

Expressed in placenta, adult brain, and fetal brain.

Gene expression databases

BgeeiQ9HBT6.
CleanExiHS_CDH20.
GenevisibleiQ9HBT6. HS.

Organism-specific databases

HPAiHPA015490.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000262717.

Structurei

3D structure databases

ProteinModelPortaliQ9HBT6.
SMRiQ9HBT6. Positions 60-595, 697-793.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 165105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini166 – 274109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 389115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini390 – 494105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini494 – 610117Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9HBT6.
KOiK06807.
OMAiEERSQYT.
OrthoDBiEOG7GBFW7.
PhylomeDBiQ9HBT6.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HBT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTSGRMSNA KNWLGLGMSL YFWGLMDLTT TVLSDTPTPQ GELEALLSDK
60 70 80 90 100
PQSHQRTKRS WVWNQFFVLE EYTGTDPLYV GKLHSDMDRG DGSIKYILSG
110 120 130 140 150
EGAGIVFTID DTTGDIHAIQ RLDREERAQY TLRAQALDRR TGRPMEPESE
160 170 180 190 200
FIIKIQDIND NEPKFLDGPY VATVPEMSPV GTSVIQVTAT DADDPTYGNS
210 220 230 240 250
ARVVYSILQG QPYFSVDSKT GVIRTALMNM DREAKEYYEV IIQAKDMGGQ
260 270 280 290 300
LGGLAGTTTV NITLSDVNDN PPRFPQKHYQ MSVLESAPIS STVGRVFAKD
310 320 330 340 350
LDEGINAEMK YTIVDGDGAD AFDISTDPNF QVGIITVKKP LSFESKKSYT
360 370 380 390 400
LKVEGANPHL EMRFLNLGPF QDTTTVHISV EDVDEPPVFE PGFYFVEVPE
410 420 430 440 450
DVAIGTTIQI ISAKDPDVTN NSIRYSIDRS SDPGRFFYVD ITTGALMTAR
460 470 480 490 500
PLDREEFSWH NITVLAMEMN NPSQVGSVPV TIKVLDVNDN APEFPRFYEA
510 520 530 540 550
FVCENAKAGQ LIQTVSAVDQ DDPRNGQHFY YSLAPEAANN PNFTIRDNQD
560 570 580 590 600
NTARILTRRS GFRQQEQSVF HLPILIADSG QPVLSSTGTL TIQVCSCDDD
610 620 630 640 650
GHVMSCSPEA YMLPVSLSRG ALIAILACIF VLLVLVLLIL SMRRHRKQPY
660 670 680 690 700
IIDDEENIHE NIVRYDDEGG GEEDTEAFDI AAMWNPREAQ AGAAPKTRQD
710 720 730 740 750
MLPEIESLSR YVPQTCAVNS TVHSYVLAKL YEADMDLWAP PFDSLQTYMF
760 770 780 790 800
EGDGSVAGSL SSLQSATSDS EQSFDFLTDW GPRFRKLAEL YGASEGPAPL

W
Length:801
Mass (Da):88,993
Last modified:February 26, 2008 - v2
Checksum:i6B8B226519F49C5E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti621 – 6211A → P in AAG23739 (PubMed:10995570).Curated
Sequence conflicti694 – 6941A → G in AAG23739 (PubMed:10995570).Curated
Sequence conflicti709 – 7091S → F in AAG23739 (PubMed:10995570).Curated
Sequence conflicti739 – 7391A → T in AAG23739 (PubMed:10995570).Curated
Sequence conflicti755 – 7551S → P in AAG23739 (PubMed:10995570).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti228 – 2281M → I in a breast cancer sample; somatic mutation. 1 Publication
VAR_036103
Natural varianti328 – 3281P → H.
Corresponds to variant rs1943330 [ dbSNP | Ensembl ].
VAR_039119
Natural varianti371 – 3711Q → R.
Corresponds to variant rs35923922 [ dbSNP | Ensembl ].
VAR_039120
Natural varianti391 – 3911P → L.
Corresponds to variant rs17068463 [ dbSNP | Ensembl ].
VAR_039121
Natural varianti416 – 4161P → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036104
Natural varianti746 – 7461Q → H in a breast cancer sample; somatic mutation. 1 Publication
VAR_036105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217289 mRNA. Translation: AAG23739.1.
CH471096 Genomic DNA. Translation: EAW63108.1.
BC101047 mRNA. Translation: AAI01048.1.
BC101048 mRNA. Translation: AAI01049.1.
BC101049 mRNA. Translation: AAI01050.1.
CCDSiCCDS11977.1.
RefSeqiNP_114097.2. NM_031891.3.
UniGeneiHs.671510.

Genome annotation databases

EnsembliENST00000262717; ENSP00000262717; ENSG00000101542.
ENST00000536675; ENSP00000444767; ENSG00000101542.
ENST00000538374; ENSP00000442226; ENSG00000101542.
GeneIDi28316.
KEGGihsa:28316.
UCSCiuc002lif.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217289 mRNA. Translation: AAG23739.1.
CH471096 Genomic DNA. Translation: EAW63108.1.
BC101047 mRNA. Translation: AAI01048.1.
BC101048 mRNA. Translation: AAI01049.1.
BC101049 mRNA. Translation: AAI01050.1.
CCDSiCCDS11977.1.
RefSeqiNP_114097.2. NM_031891.3.
UniGeneiHs.671510.

3D structure databases

ProteinModelPortaliQ9HBT6.
SMRiQ9HBT6. Positions 60-595, 697-793.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000262717.

PTM databases

iPTMnetiQ9HBT6.
PhosphoSiteiQ9HBT6.

Polymorphism and mutation databases

BioMutaiCDH20.
DMDMi190359622.

Proteomic databases

PaxDbiQ9HBT6.
PRIDEiQ9HBT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262717; ENSP00000262717; ENSG00000101542.
ENST00000536675; ENSP00000444767; ENSG00000101542.
ENST00000538374; ENSP00000442226; ENSG00000101542.
GeneIDi28316.
KEGGihsa:28316.
UCSCiuc002lif.3. human.

Organism-specific databases

CTDi28316.
GeneCardsiCDH20.
H-InvDBHIX0014487.
HGNCiHGNC:1760. CDH20.
HPAiHPA015490.
MIMi605807. gene.
neXtProtiNX_Q9HBT6.
PharmGKBiPA26294.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9HBT6.
KOiK06807.
OMAiEERSQYT.
OrthoDBiEOG7GBFW7.
PhylomeDBiQ9HBT6.
TreeFamiTF329887.

Miscellaneous databases

GenomeRNAii28316.
PROiQ9HBT6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HBT6.
CleanExiHS_CDH20.
GenevisibleiQ9HBT6. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7."
    Kools P., Van Imschoot G., van Roy F.
    Genomics 68:283-295(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-228; THR-416 AND HIS-746.

Entry informationi

Entry nameiCAD20_HUMAN
AccessioniPrimary (citable) accession number: Q9HBT6
Secondary accession number(s): Q495S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: February 26, 2008
Last modified: June 8, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.