Q9HBT6 (CAD20_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cadherin-20

Gene names

Name:	CDH20
Synonyms:	CDH7L3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	801 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed in placenta, adult brain, and fetal brain.
Sequence similarities	Contains 5 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Cleavage on pair of basic residues Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	homophilic cell adhesion Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34	Potential
	Propeptide	35 – 59	25	Potential		PRO_0000003819
	Chain	60 – 801	742	Cadherin-20		PRO_0000003820
Regions
	Topological domain	60 – 619	560	Extracellular Potential
	Transmembrane	620 – 640	21	Helical; Potential
	Topological domain	641 – 801	161	Cytoplasmic Potential
	Domain	61 – 165	105	Cadherin 1
	Domain	166 – 274	109	Cadherin 2
	Domain	275 – 389	115	Cadherin 3
	Domain	390 – 494	105	Cadherin 4
	Domain	494 – 610	117	Cadherin 5
Amino acid modifications
	Glycosylation	261	1	N-linked (GlcNAc...) Potential
	Glycosylation	420	1	N-linked (GlcNAc...) Potential
	Glycosylation	461	1	N-linked (GlcNAc...) Potential
	Glycosylation	542	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	228	1	M → I in a breast cancer sample; somatic mutation. Ref.4		VAR_036103
	Natural variant	328	1	P → H. Corresponds to variant rs1943330 [ dbSNP | Ensembl ].		VAR_039119
	Natural variant	371	1	Q → R. Corresponds to variant rs35923922 [ dbSNP | Ensembl ].		VAR_039120
	Natural variant	391	1	P → L. Corresponds to variant rs17068463 [ dbSNP | Ensembl ].		VAR_039121
	Natural variant	416	1	P → T in a breast cancer sample; somatic mutation. Ref.4		VAR_036104
	Natural variant	746	1	Q → H in a breast cancer sample; somatic mutation. Ref.4		VAR_036105
Experimental info
	Sequence conflict	621	1	A → P in AAG23739. Ref.1
	Sequence conflict	694	1	A → G in AAG23739. Ref.1
	Sequence conflict	709	1	S → F in AAG23739. Ref.1
	Sequence conflict	739	1	A → T in AAG23739. Ref.1
	Sequence conflict	755	1	S → P in AAG23739. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9HBT6 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 6B8B226519F49C5E	FASTA	801	88,993
	10 20 30 40 50 60 MWTSGRMSNA KNWLGLGMSL YFWGLMDLTT TVLSDTPTPQ GELEALLSDK PQSHQRTKRS 70 80 90 100 110 120 WVWNQFFVLE EYTGTDPLYV GKLHSDMDRG DGSIKYILSG EGAGIVFTID DTTGDIHAIQ 130 140 150 160 170 180 RLDREERAQY TLRAQALDRR TGRPMEPESE FIIKIQDIND NEPKFLDGPY VATVPEMSPV 190 200 210 220 230 240 GTSVIQVTAT DADDPTYGNS ARVVYSILQG QPYFSVDSKT GVIRTALMNM DREAKEYYEV 250 260 270 280 290 300 IIQAKDMGGQ LGGLAGTTTV NITLSDVNDN PPRFPQKHYQ MSVLESAPIS STVGRVFAKD 310 320 330 340 350 360 LDEGINAEMK YTIVDGDGAD AFDISTDPNF QVGIITVKKP LSFESKKSYT LKVEGANPHL 370 380 390 400 410 420 EMRFLNLGPF QDTTTVHISV EDVDEPPVFE PGFYFVEVPE DVAIGTTIQI ISAKDPDVTN 430 440 450 460 470 480 NSIRYSIDRS SDPGRFFYVD ITTGALMTAR PLDREEFSWH NITVLAMEMN NPSQVGSVPV 490 500 510 520 530 540 TIKVLDVNDN APEFPRFYEA FVCENAKAGQ LIQTVSAVDQ DDPRNGQHFY YSLAPEAANN 550 560 570 580 590 600 PNFTIRDNQD NTARILTRRS GFRQQEQSVF HLPILIADSG QPVLSSTGTL TIQVCSCDDD 610 620 630 640 650 660 GHVMSCSPEA YMLPVSLSRG ALIAILACIF VLLVLVLLIL SMRRHRKQPY IIDDEENIHE 670 680 690 700 710 720 NIVRYDDEGG GEEDTEAFDI AAMWNPREAQ AGAAPKTRQD MLPEIESLSR YVPQTCAVNS 730 740 750 760 770 780 TVHSYVLAKL YEADMDLWAP PFDSLQTYMF EGDGSVAGSL SSLQSATSDS EQSFDFLTDW 790 800 GPRFRKLAEL YGASEGPAPL W

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7." Kools P., Van Imschoot G., van Roy F. Genomics 68:283-295(2000) [PubMed: 10995570] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-228; THR-416 AND HIS-746.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF217289 mRNA. Translation: AAG23739.1. CH471096 Genomic DNA. Translation: EAW63108.1. BC101047 mRNA. Translation: AAI01048.1. BC101048 mRNA. Translation: AAI01049.1. BC101049 mRNA. Translation: AAI01050.1.
IPI	IPI00307612.
RefSeq	NP_114097.2. NM_031891.2.
UniGene	Hs.671510.
3D structure databases
ProteinModelPortal	Q9HBT6.
SMR	Q9HBT6. Positions 60-595, 697-794.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9HBT6.
PTM databases
PhosphoSite	Q9HBT6.
Polymorphism databases
DMDM	190359622.
Proteomic databases
PRIDE	Q9HBT6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262717; ENSP00000262717; ENSG00000101542.
GeneID	28316.
KEGG	hsa:28316.
UCSC	uc002lif.2. human.
Organism-specific databases
CTD	28316.
GeneCards	GC18P058988.
H-InvDB	HIX0014487.
HGNC	HGNC:1760. CDH20.
HPA	HPA015490.
MIM	605807. gene.
neXtProt	NX_Q9HBT6.
PharmGKB	PA26294.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05873.
GeneTree	ENSGT00590000082742.
HOGENOM	HBG505775.
HOVERGEN	HBG005217.
InParanoid	Q9HBT6.
OMA	NNPSQVG.
OrthoDB	EOG408N7J.
PhylomeDB	Q9HBT6.
Gene expression databases
ArrayExpress	Q9HBT6.
Bgee	Q9HBT6.
CleanEx	HS_CDH20.
Genevestigator	Q9HBT6.
GermOnline	ENSG00000101542. Homo sapiens.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR000233. Cadherin_cytoplasmic-dom. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 5 hits.
KO	K06807.
Pfam	PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 5 hits.
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	50592.
SOURCE	Search...

Entry information

Entry name

CAD20_HUMAN

Accession

Primary (citable) accession number: Q9HBT6
Secondary accession number(s): Q495S3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2001
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.