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Q9HBR0 (S38AA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative sodium-coupled neutral amino acid transporter 10
Alternative name(s):
Solute carrier family 38 member 10
Gene names
Name:SLC38A10
ORF Names:PP1744
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1119 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative sodium-dependent amino acid/proton antiporter By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.

Sequence caution

The sequence AAG17235.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC04027.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9HBR0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HBR0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     689-780: EAGRAEMLDH...ETVENLPPLP → GKASALQPPA...DYRFISLAPL
     781-1119: Missing.
Isoform 3 (identifier: Q9HBR0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     768-768: K → S
     769-1119: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11191119Putative sodium-coupled neutral amino acid transporter 10
PRO_0000318975

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane36 – 5823Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane153 – 17321Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane272 – 29221Helical; Potential
Transmembrane323 – 34321Helical; Potential
Transmembrane345 – 36521Helical; Potential
Transmembrane378 – 39821Helical; Potential

Natural variations

Alternative sequence1 – 8282Missing in isoform 3.
VSP_031323
Alternative sequence689 – 78092EAGRA…LPPLP → GKASALQPPASGPGSGSPLP QPWGDAQVILGSPARPPFSF QPPAEQTPRRAFCSLPISSL LSGNLLSALLPFKHLRHRHM ACDYRFISLAPL in isoform 2.
VSP_031324
Alternative sequence7681K → S in isoform 3.
VSP_031325
Alternative sequence769 – 1119351Missing in isoform 3.
VSP_031326
Alternative sequence781 – 1119339Missing in isoform 2.
VSP_031327
Natural variant5591K → R.
Corresponds to variant rs35546507 [ dbSNP | Ensembl ].
VAR_048126
Natural variant8311A → G. Ref.5
Corresponds to variant rs2725405 [ dbSNP | Ensembl ].
VAR_038927

Experimental info

Sequence conflict10711Missing in AAG17235. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: F328CFEB6A5336D9

FASTA1,119119,762
        10         20         30         40         50         60 
MTAAAASNWG LITNIVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT HQSCMFLVKS 

        70         80         90        100        110        120 
ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGTCIAF YVVIGDLGSN FFARLFGFQV 

       130        140        150        160        170        180 
GGTFRMFLLF AVSLCIVLPL SLQRNMMASI QSFSAMALLF YTVFMFVIVL SSLKHGLFSG 

       190        200        210        220        230        240 
QWLRRVSYVR WEGVFRCIPI FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTTF 

       250        260        270        280        290        300 
YVMVGFFGYV SFTEATAGNV LMHFPSNLVT EMLRVGFMMS VAVGFPMMIL PCRQALSTLL 

       310        320        330        340        350        360 
CEQQQKDGTF AAGGYMPPLR FKALTLSVVF GTMVGGILIP NVETILGLTG ATMGSLICFI 

       370        380        390        400        410        420 
CPALIYKKIH KNALSSQVVL WVGLGVLVVS TVTTLSVSEE VPEDLAEEAP GGRLGEAEGL 

       430        440        450        460        470        480 
MKVEAARLSA QDPVVAVAED GREKPKLPKE REELEQAQIK GPVDVPGRED GKEAPEEAQL 

       490        500        510        520        530        540 
DRPGQGIAVP VGEAHRHEPP VPHDKVVVDE GQDREVPEEN KPPSRHAGGK APGVQGQMAP 

       550        560        570        580        590        600 
PLPDSEREKQ EPEQGEVGKR PGQAQALEEA GDLPEDPQKV PEADGQPAVQ PAKEDLGPGD 

       610        620        630        640        650        660 
RGLHPRPQAV LSEQQNGLAV GGGEKAKGGP PPGNAAGDTG QPAEDSDHGG KPPLPAEKPA 

       670        680        690        700        710        720 
PGPGLPPEPR EQRDVERAGG NQAASQLEEA GRAEMLDHAV LLQVIKEQQV QQKRLLDQQE 

       730        740        750        760        770        780 
KLLAVIEEQH KEIHQQRQED EEDKPRQVEV HQEPGAAVPR GQEAPEGKAR ETVENLPPLP 

       790        800        810        820        830        840 
LDPVLRAPGG RPAPSQDLNQ RSLEHSEGPV GRDPAGPPDG GPDTEPRAAQ AKLRDGQKDA 

       850        860        870        880        890        900 
APRAAGTVKE LPKGPEQVPV PDPAREAGGP EERLAEEFPG QSQDVTGGSQ DRKKPGKEVA 

       910        920        930        940        950        960 
ATGTSILKEA NWLVAGPGAE TGDPRMKPKQ VSRDLGLAAD LPGGAEGAAA QPQAVLRQPE 

       970        980        990       1000       1010       1020 
LRVISDGEQG GQQGHRLDHG GHLEMRKARG GDHVPVSHEQ PRGGEDAAVQ EPRQRPEPEL 

      1030       1040       1050       1060       1070       1080 
GLKRAVPGGQ RPDNAKPNRD LKLQAGSDLR RRRRDLGPHA EGQLAPRDGV IIGLNPLPDV 

      1090       1100       1110 
QVNDLRGALD AQLRQAAGGA LQVVHSRQLR QAPGPPEES 

« Hide

Isoform 2 [UniParc].

Checksum: E529A228C8842312
Show »

FASTA78083,324
Isoform 3 [UniParc].

Checksum: F260EB0E42807634
Show »

FASTA68673,978

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 209-1119 (ISOFORM 2).
Tissue: Thymus.
[2]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Muscle.
[5]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 784-1119, VARIANT GLY-831.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK093037 mRNA. Translation: BAC04027.1. Different initiation.
AK128330 mRNA. Translation: BAC87387.1.
AC027601 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89643.1.
BC014642 mRNA. Translation: AAH14642.1.
AF217993 mRNA. Translation: AAG17235.1. Different initiation.
CCDSCCDS11780.1. [Q9HBR0-2]
CCDS42397.1. [Q9HBR0-1]
RefSeqNP_001033073.1. NM_001037984.2. [Q9HBR0-1]
NP_612637.1. NM_138570.3. [Q9HBR0-2]
UniGeneHs.352240.

3D structure databases

ProteinModelPortalQ9HBR0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125874. 1 interaction.

Protein family/group databases

TCDB2.A.18.6.16. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSiteQ9HBR0.

Polymorphism databases

DMDM172045932.

Proteomic databases

MaxQBQ9HBR0.
PaxDbQ9HBR0.
PeptideAtlasQ9HBR0.
PRIDEQ9HBR0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000288439; ENSP00000288439; ENSG00000157637. [Q9HBR0-2]
ENST00000374759; ENSP00000363891; ENSG00000157637. [Q9HBR0-1]
GeneID124565.
KEGGhsa:124565.
UCSCuc002jzy.1. human. [Q9HBR0-1]
uc002kab.3. human. [Q9HBR0-2]

Organism-specific databases

CTD124565.
GeneCardsGC17M079218.
HGNCHGNC:28237. SLC38A10.
HPAHPA021374.
HPA023161.
HPA024631.
neXtProtNX_Q9HBR0.
PharmGKBPA162403738.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0814.
HOGENOMHOG000154237.
HOVERGENHBG097690.
InParanoidQ9HBR0.
KOK14996.
OMAVVHSRQL.
OrthoDBEOG7KM5SR.
PhylomeDBQ9HBR0.
TreeFamTF320116.

Gene expression databases

ArrayExpressQ9HBR0.
BgeeQ9HBR0.
CleanExHS_SLC38A10.
GenevestigatorQ9HBR0.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC38A10. human.
GeneWikiSLC38A10.
GenomeRNAi124565.
NextBio81322.
PROQ9HBR0.

Entry information

Entry nameS38AA_HUMAN
AccessionPrimary (citable) accession number: Q9HBR0
Secondary accession number(s): Q6ZRC5, Q8NA99, Q96C66
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM