Q9HBR0 (S38AA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative sodium-coupled neutral amino acid transporter 10

Gene names

Name:	SLC38A10
ORF Names:	PP1744

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1119 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative sodium-dependent amino acid/proton antiporter By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the amino acid/polyamine transporter 2 family.
Sequence caution	The sequence AAG17235.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC04027.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid transport Ion transport Sodium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	amino acid transport Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HBR0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HBR0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     689-780: EAGRAEMLDH...ETVENLPPLP → GKASALQPPA...DYRFISLAPL
     781-1119: Missing.

Isoform 3 (identifier: Q9HBR0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     768-768: K → S
     769-1119: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1119	1119	Putative sodium-coupled neutral amino acid transporter 10		PRO_0000318975
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	36 – 58	23	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	120 – 140	21	Helical; Potential
	Transmembrane	153 – 173	21	Helical; Potential
	Transmembrane	229 – 249	21	Helical; Potential
	Transmembrane	272 – 292	21	Helical; Potential
	Transmembrane	323 – 343	21	Helical; Potential
	Transmembrane	345 – 365	21	Helical; Potential
	Transmembrane	378 – 398	21	Helical; Potential
Amino acid modifications
	Modified residue	889	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 82	82	Missing in isoform 3.		VSP_031323
	Alternative sequence	689 – 780	92	EAGRA…LPPLP → GKASALQPPASGPGSGSPLP QPWGDAQVILGSPARPPFSF QPPAEQTPRRAFCSLPISSL LSGNLLSALLPFKHLRHRHM ACDYRFISLAPL in isoform 2.		VSP_031324
	Alternative sequence	768	1	K → S in isoform 3.		VSP_031325
	Alternative sequence	769 – 1119	351	Missing in isoform 3.		VSP_031326
	Alternative sequence	781 – 1119	339	Missing in isoform 2.		VSP_031327
	Natural variant	559	1	K → R. Corresponds to variant rs35546507 [ dbSNP | Ensembl ].		VAR_048126
	Natural variant	831	1	A → G. Ref.5 Corresponds to variant rs2725405 [ dbSNP | Ensembl ].		VAR_038927
Experimental info
	Sequence conflict	1071	1	Missing in AAG17235. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: F328CFEB6A5336D9	FASTA	1,119	119,762
	10 20 30 40 50 60 MTAAAASNWG LITNIVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT HQSCMFLVKS 70 80 90 100 110 120 ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGTCIAF YVVIGDLGSN FFARLFGFQV 130 140 150 160 170 180 GGTFRMFLLF AVSLCIVLPL SLQRNMMASI QSFSAMALLF YTVFMFVIVL SSLKHGLFSG 190 200 210 220 230 240 QWLRRVSYVR WEGVFRCIPI FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTTF 250 260 270 280 290 300 YVMVGFFGYV SFTEATAGNV LMHFPSNLVT EMLRVGFMMS VAVGFPMMIL PCRQALSTLL 310 320 330 340 350 360 CEQQQKDGTF AAGGYMPPLR FKALTLSVVF GTMVGGILIP NVETILGLTG ATMGSLICFI 370 380 390 400 410 420 CPALIYKKIH KNALSSQVVL WVGLGVLVVS TVTTLSVSEE VPEDLAEEAP GGRLGEAEGL 430 440 450 460 470 480 MKVEAARLSA QDPVVAVAED GREKPKLPKE REELEQAQIK GPVDVPGRED GKEAPEEAQL 490 500 510 520 530 540 DRPGQGIAVP VGEAHRHEPP VPHDKVVVDE GQDREVPEEN KPPSRHAGGK APGVQGQMAP 550 560 570 580 590 600 PLPDSEREKQ EPEQGEVGKR PGQAQALEEA GDLPEDPQKV PEADGQPAVQ PAKEDLGPGD 610 620 630 640 650 660 RGLHPRPQAV LSEQQNGLAV GGGEKAKGGP PPGNAAGDTG QPAEDSDHGG KPPLPAEKPA 670 680 690 700 710 720 PGPGLPPEPR EQRDVERAGG NQAASQLEEA GRAEMLDHAV LLQVIKEQQV QQKRLLDQQE 730 740 750 760 770 780 KLLAVIEEQH KEIHQQRQED EEDKPRQVEV HQEPGAAVPR GQEAPEGKAR ETVENLPPLP 790 800 810 820 830 840 LDPVLRAPGG RPAPSQDLNQ RSLEHSEGPV GRDPAGPPDG GPDTEPRAAQ AKLRDGQKDA 850 860 870 880 890 900 APRAAGTVKE LPKGPEQVPV PDPAREAGGP EERLAEEFPG QSQDVTGGSQ DRKKPGKEVA 910 920 930 940 950 960 ATGTSILKEA NWLVAGPGAE TGDPRMKPKQ VSRDLGLAAD LPGGAEGAAA QPQAVLRQPE 970 980 990 1000 1010 1020 LRVISDGEQG GQQGHRLDHG GHLEMRKARG GDHVPVSHEQ PRGGEDAAVQ EPRQRPEPEL 1030 1040 1050 1060 1070 1080 GLKRAVPGGQ RPDNAKPNRD LKLQAGSDLR RRRRDLGPHA EGQLAPRDGV IIGLNPLPDV 1090 1100 1110 QVNDLRGALD AQLRQAAGGA LQVVHSRQLR QAPGPPEES
	Isoform 2 [UniParc]. Checksum: E529A228C8842312	FASTA	780	83,324
	10 20 30 40 50 60 MTAAAASNWG LITNIVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT HQSCMFLVKS 70 80 90 100 110 120 ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGTCIAF YVVIGDLGSN FFARLFGFQV 130 140 150 160 170 180 GGTFRMFLLF AVSLCIVLPL SLQRNMMASI QSFSAMALLF YTVFMFVIVL SSLKHGLFSG 190 200 210 220 230 240 QWLRRVSYVR WEGVFRCIPI FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTTF 250 260 270 280 290 300 YVMVGFFGYV SFTEATAGNV LMHFPSNLVT EMLRVGFMMS VAVGFPMMIL PCRQALSTLL 310 320 330 340 350 360 CEQQQKDGTF AAGGYMPPLR FKALTLSVVF GTMVGGILIP NVETILGLTG ATMGSLICFI 370 380 390 400 410 420 CPALIYKKIH KNALSSQVVL WVGLGVLVVS TVTTLSVSEE VPEDLAEEAP GGRLGEAEGL 430 440 450 460 470 480 MKVEAARLSA QDPVVAVAED GREKPKLPKE REELEQAQIK GPVDVPGRED GKEAPEEAQL 490 500 510 520 530 540 DRPGQGIAVP VGEAHRHEPP VPHDKVVVDE GQDREVPEEN KPPSRHAGGK APGVQGQMAP 550 560 570 580 590 600 PLPDSEREKQ EPEQGEVGKR PGQAQALEEA GDLPEDPQKV PEADGQPAVQ PAKEDLGPGD 610 620 630 640 650 660 RGLHPRPQAV LSEQQNGLAV GGGEKAKGGP PPGNAAGDTG QPAEDSDHGG KPPLPAEKPA 670 680 690 700 710 720 PGPGLPPEPR EQRDVERAGG NQAASQLEGK ASALQPPASG PGSGSPLPQP WGDAQVILGS 730 740 750 760 770 780 PARPPFSFQP PAEQTPRRAF CSLPISSLLS GNLLSALLPF KHLRHRHMAC DYRFISLAPL
	Isoform 3 [UniParc]. Checksum: F260EB0E42807634	FASTA	686	73,978
	10 20 30 40 50 60 MLVETSMIGL MLGTCIAFYV VIGDLGSNFF ARLFGFQVGG TFRMFLLFAV SLCIVLPLSL 70 80 90 100 110 120 QRNMMASIQS FSAMALLFYT VFMFVIVLSS LKHGLFSGQW LRRVSYVRWE GVFRCIPIFG 130 140 150 160 170 180 MSFACQSQVL PTYDSLDEPS VKTMSSIFAS SLNVVTTFYV MVGFFGYVSF TEATAGNVLM 190 200 210 220 230 240 HFPSNLVTEM LRVGFMMSVA VGFPMMILPC RQALSTLLCE QQQKDGTFAA GGYMPPLRFK 250 260 270 280 290 300 ALTLSVVFGT MVGGILIPNV ETILGLTGAT MGSLICFICP ALIYKKIHKN ALSSQVVLWV 310 320 330 340 350 360 GLGVLVVSTV TTLSVSEEVP EDLAEEAPGG RLGEAEGLMK VEAARLSAQD PVVAVAEDGR 370 380 390 400 410 420 EKPKLPKERE ELEQAQIKGP VDVPGREDGK EAPEEAQLDR PGQGIAVPVG EAHRHEPPVP 430 440 450 460 470 480 HDKVVVDEGQ DREVPEENKP PSRHAGGKAP GVQGQMAPPL PDSEREKQEP EQGEVGKRPG 490 500 510 520 530 540 QAQALEEAGD LPEDPQKVPE ADGQPAVQPA KEDLGPGDRG LHPRPQAVLS EQQNGLAVGG 550 560 570 580 590 600 GEKAKGGPPP GNAAGDTGQP AEDSDHGGKP PLPAEKPAPG PGLPPEPREQ RDVERAGGNQ 610 620 630 640 650 660 AASQLEEAGR AEMLDHAVLL QVIKEQQVQQ KRLLDQQEKL LAVIEEQHKE IHQQRQEDEE 670 680 DKPRQVEVHQ EPGAAVPRGQ EAPEGS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 209-1119 (ISOFORM 2). Tissue: Thymus.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Muscle.
[5]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 784-1119, VARIANT GLY-831.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK093037 mRNA. Translation: BAC04027.1. Different initiation. AK128330 mRNA. Translation: BAC87387.1. AC027601 Genomic DNA. No translation available. CH471099 Genomic DNA. Translation: EAW89643.1. BC014642 mRNA. Translation: AAH14642.1. AF217993 mRNA. Translation: AAG17235.1. Different initiation.
IPI	IPI00060283. IPI00443799. IPI00884960.
RefSeq	NP_001033073.1. NM_001037984.1. NP_612637.1. NM_138570.2.
UniGene	Hs.352240.
3D structure databases
ProteinModelPortal	Q9HBR0.
ModBase	Search...
PTM databases
PhosphoSite	Q9HBR0.
Polymorphism databases
DMDM	172045932.
Proteomic databases
PaxDb	Q9HBR0.
PeptideAtlas	Q9HBR0.
PRIDE	Q9HBR0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000288439; ENSP00000288439; ENSG00000157637. ENST00000374759; ENSP00000363891; ENSG00000157637.
GeneID	124565.
KEGG	hsa:124565.
UCSC	uc002jzy.1. human. uc002kab.3. human.
Organism-specific databases
CTD	124565.
GeneCards	GC17M079218.
HGNC	HGNC:28237. SLC38A10.
HPA	HPA021374. HPA023161. HPA024631.
neXtProt	NX_Q9HBR0.
PharmGKB	PA162403738.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0814.
HOGENOM	HOG000154237.
HOVERGEN	HBG097690.
InParanoid	Q9HBR0.
KO	K14996.
OMA	VVHSRQL.
OrthoDB	EOG4QRH38.
Gene expression databases
ArrayExpress	Q9HBR0.
Bgee	Q9HBR0.
CleanEx	HS_SLC38A10.
Genevestigator	Q9HBR0.
Family and domain databases
InterPro	IPR013057. AA_transpt_TM. [Graphical view]
Pfam	PF01490. Aa_trans. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC38A10. human.
GenomeRNAi	124565.
NextBio	81322.

Entry information

Entry name

S38AA_HUMAN

Accession

Primary (citable) accession number: Q9HBR0
Secondary accession number(s): Q6ZRC5, Q8NA99, Q96C66

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	March 6, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.