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Protein

Putative sodium-coupled neutral amino acid transporter 10

Gene

SLC38A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative sodium-dependent amino acid/proton antiporter.By similarity

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: GO_Central

GO - Biological processi

  1. amino acid transmembrane transport Source: GO_Central
  2. bone development Source: Ensembl
  3. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.18.6.16. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-coupled neutral amino acid transporter 10
Alternative name(s):
Solute carrier family 38 member 10
Gene namesi
ORF Names:PP1744
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:28237. SLC38A10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Transmembranei36 – 5823HelicalSequence AnalysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence AnalysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence AnalysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence AnalysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403738.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11191119Putative sodium-coupled neutral amino acid transporter 10PRO_0000318975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei772 – 7721Phosphothreonine1 Publication
Modified residuei802 – 8021Phosphoserine1 Publication
Modified residuei965 – 9651Phosphoserine1 Publication
Modified residuei997 – 9971Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9HBR0.
PaxDbiQ9HBR0.
PeptideAtlasiQ9HBR0.
PRIDEiQ9HBR0.

PTM databases

PhosphoSiteiQ9HBR0.

Expressioni

Gene expression databases

BgeeiQ9HBR0.
CleanExiHS_SLC38A10.
ExpressionAtlasiQ9HBR0. baseline and differential.
GenevestigatoriQ9HBR0.

Organism-specific databases

HPAiHPA021374.
HPA023161.
HPA024631.

Interactioni

Protein-protein interaction databases

BioGridi125874. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9HBR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000154237.
HOVERGENiHBG097690.
InParanoidiQ9HBR0.
KOiK14996.
OMAiIFYTLFM.
OrthoDBiEOG7KM5SR.
PhylomeDBiQ9HBR0.
TreeFamiTF320116.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HBR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAAAASNWG LITNIVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT
60 70 80 90 100
HQSCMFLVKS ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGTCIAF
110 120 130 140 150
YVVIGDLGSN FFARLFGFQV GGTFRMFLLF AVSLCIVLPL SLQRNMMASI
160 170 180 190 200
QSFSAMALLF YTVFMFVIVL SSLKHGLFSG QWLRRVSYVR WEGVFRCIPI
210 220 230 240 250
FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTTF YVMVGFFGYV
260 270 280 290 300
SFTEATAGNV LMHFPSNLVT EMLRVGFMMS VAVGFPMMIL PCRQALSTLL
310 320 330 340 350
CEQQQKDGTF AAGGYMPPLR FKALTLSVVF GTMVGGILIP NVETILGLTG
360 370 380 390 400
ATMGSLICFI CPALIYKKIH KNALSSQVVL WVGLGVLVVS TVTTLSVSEE
410 420 430 440 450
VPEDLAEEAP GGRLGEAEGL MKVEAARLSA QDPVVAVAED GREKPKLPKE
460 470 480 490 500
REELEQAQIK GPVDVPGRED GKEAPEEAQL DRPGQGIAVP VGEAHRHEPP
510 520 530 540 550
VPHDKVVVDE GQDREVPEEN KPPSRHAGGK APGVQGQMAP PLPDSEREKQ
560 570 580 590 600
EPEQGEVGKR PGQAQALEEA GDLPEDPQKV PEADGQPAVQ PAKEDLGPGD
610 620 630 640 650
RGLHPRPQAV LSEQQNGLAV GGGEKAKGGP PPGNAAGDTG QPAEDSDHGG
660 670 680 690 700
KPPLPAEKPA PGPGLPPEPR EQRDVERAGG NQAASQLEEA GRAEMLDHAV
710 720 730 740 750
LLQVIKEQQV QQKRLLDQQE KLLAVIEEQH KEIHQQRQED EEDKPRQVEV
760 770 780 790 800
HQEPGAAVPR GQEAPEGKAR ETVENLPPLP LDPVLRAPGG RPAPSQDLNQ
810 820 830 840 850
RSLEHSEGPV GRDPAGPPDG GPDTEPRAAQ AKLRDGQKDA APRAAGTVKE
860 870 880 890 900
LPKGPEQVPV PDPAREAGGP EERLAEEFPG QSQDVTGGSQ DRKKPGKEVA
910 920 930 940 950
ATGTSILKEA NWLVAGPGAE TGDPRMKPKQ VSRDLGLAAD LPGGAEGAAA
960 970 980 990 1000
QPQAVLRQPE LRVISDGEQG GQQGHRLDHG GHLEMRKARG GDHVPVSHEQ
1010 1020 1030 1040 1050
PRGGEDAAVQ EPRQRPEPEL GLKRAVPGGQ RPDNAKPNRD LKLQAGSDLR
1060 1070 1080 1090 1100
RRRRDLGPHA EGQLAPRDGV IIGLNPLPDV QVNDLRGALD AQLRQAAGGA
1110
LQVVHSRQLR QAPGPPEES
Length:1,119
Mass (Da):119,762
Last modified:February 26, 2008 - v2
Checksum:iF328CFEB6A5336D9
GO
Isoform 2 (identifier: Q9HBR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     689-780: EAGRAEMLDH...ETVENLPPLP → GKASALQPPA...DYRFISLAPL
     781-1119: Missing.

Show »
Length:780
Mass (Da):83,324
Checksum:iE529A228C8842312
GO
Isoform 3 (identifier: Q9HBR0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     768-768: K → S
     769-1119: Missing.

Note: No experimental confirmation available.

Show »
Length:686
Mass (Da):73,978
Checksum:iF260EB0E42807634
GO

Sequence cautioni

The sequence AAG17235.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC04027.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1071 – 10711Missing in AAG17235 (PubMed:15498874).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti559 – 5591K → R.
Corresponds to variant rs35546507 [ dbSNP | Ensembl ].
VAR_048126
Natural varianti831 – 8311A → G.1 Publication
Corresponds to variant rs2725405 [ dbSNP | Ensembl ].
VAR_038927

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282Missing in isoform 3. 1 PublicationVSP_031323Add
BLAST
Alternative sequencei689 – 78092EAGRA…LPPLP → GKASALQPPASGPGSGSPLP QPWGDAQVILGSPARPPFSF QPPAEQTPRRAFCSLPISSL LSGNLLSALLPFKHLRHRHM ACDYRFISLAPL in isoform 2. 2 PublicationsVSP_031324Add
BLAST
Alternative sequencei768 – 7681K → S in isoform 3. 1 PublicationVSP_031325
Alternative sequencei769 – 1119351Missing in isoform 3. 1 PublicationVSP_031326Add
BLAST
Alternative sequencei781 – 1119339Missing in isoform 2. 2 PublicationsVSP_031327Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093037 mRNA. Translation: BAC04027.1. Different initiation.
AK128330 mRNA. Translation: BAC87387.1.
AC027601 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89643.1.
BC014642 mRNA. Translation: AAH14642.1.
AF217993 mRNA. Translation: AAG17235.1. Different initiation.
CCDSiCCDS11780.1. [Q9HBR0-2]
CCDS42397.1. [Q9HBR0-1]
RefSeqiNP_001033073.1. NM_001037984.2. [Q9HBR0-1]
NP_612637.1. NM_138570.3. [Q9HBR0-2]
UniGeneiHs.352240.

Genome annotation databases

EnsembliENST00000288439; ENSP00000288439; ENSG00000157637. [Q9HBR0-2]
ENST00000374759; ENSP00000363891; ENSG00000157637. [Q9HBR0-1]
GeneIDi124565.
KEGGihsa:124565.
UCSCiuc002jzy.1. human. [Q9HBR0-1]
uc002kab.3. human. [Q9HBR0-2]

Polymorphism databases

DMDMi172045932.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093037 mRNA. Translation: BAC04027.1. Different initiation.
AK128330 mRNA. Translation: BAC87387.1.
AC027601 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89643.1.
BC014642 mRNA. Translation: AAH14642.1.
AF217993 mRNA. Translation: AAG17235.1. Different initiation.
CCDSiCCDS11780.1. [Q9HBR0-2]
CCDS42397.1. [Q9HBR0-1]
RefSeqiNP_001033073.1. NM_001037984.2. [Q9HBR0-1]
NP_612637.1. NM_138570.3. [Q9HBR0-2]
UniGeneiHs.352240.

3D structure databases

ProteinModelPortaliQ9HBR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125874. 7 interactions.

Protein family/group databases

TCDBi2.A.18.6.16. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSiteiQ9HBR0.

Polymorphism databases

DMDMi172045932.

Proteomic databases

MaxQBiQ9HBR0.
PaxDbiQ9HBR0.
PeptideAtlasiQ9HBR0.
PRIDEiQ9HBR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288439; ENSP00000288439; ENSG00000157637. [Q9HBR0-2]
ENST00000374759; ENSP00000363891; ENSG00000157637. [Q9HBR0-1]
GeneIDi124565.
KEGGihsa:124565.
UCSCiuc002jzy.1. human. [Q9HBR0-1]
uc002kab.3. human. [Q9HBR0-2]

Organism-specific databases

CTDi124565.
GeneCardsiGC17M079218.
HGNCiHGNC:28237. SLC38A10.
HPAiHPA021374.
HPA023161.
HPA024631.
neXtProtiNX_Q9HBR0.
PharmGKBiPA162403738.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000154237.
HOVERGENiHBG097690.
InParanoidiQ9HBR0.
KOiK14996.
OMAiIFYTLFM.
OrthoDBiEOG7KM5SR.
PhylomeDBiQ9HBR0.
TreeFamiTF320116.

Miscellaneous databases

ChiTaRSiSLC38A10. human.
GeneWikiiSLC38A10.
GenomeRNAii124565.
NextBioi81322.
PROiQ9HBR0.

Gene expression databases

BgeeiQ9HBR0.
CleanExiHS_SLC38A10.
ExpressionAtlasiQ9HBR0. baseline and differential.
GenevestigatoriQ9HBR0.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 209-1119 (ISOFORM 2).
    Tissue: Thymus.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Muscle.
  5. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 784-1119, VARIANT GLY-831.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-772; SER-802; SER-965 AND SER-997, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiS38AA_HUMAN
AccessioniPrimary (citable) accession number: Q9HBR0
Secondary accession number(s): Q6ZRC5, Q8NA99, Q96C66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: March 4, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.