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Q9HBR0

- S38AA_HUMAN

UniProt

Q9HBR0 - S38AA_HUMAN

Protein

Putative sodium-coupled neutral amino acid transporter 10

Gene

SLC38A10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Putative sodium-dependent amino acid/proton antiporter.By similarity

    GO - Biological processi

    1. amino acid transport Source: UniProtKB-KW
    2. bone development Source: Ensembl
    3. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Amino-acid transport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Protein family/group databases

    TCDBi2.A.18.6.16. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative sodium-coupled neutral amino acid transporter 10
    Alternative name(s):
    Solute carrier family 38 member 10
    Gene namesi
    ORF Names:PP1744
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:28237. SLC38A10.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: HPA
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162403738.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11191119Putative sodium-coupled neutral amino acid transporter 10PRO_0000318975Add
    BLAST

    Proteomic databases

    MaxQBiQ9HBR0.
    PaxDbiQ9HBR0.
    PeptideAtlasiQ9HBR0.
    PRIDEiQ9HBR0.

    PTM databases

    PhosphoSiteiQ9HBR0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9HBR0.
    BgeeiQ9HBR0.
    CleanExiHS_SLC38A10.
    GenevestigatoriQ9HBR0.

    Organism-specific databases

    HPAiHPA021374.
    HPA023161.
    HPA024631.

    Interactioni

    Protein-protein interaction databases

    BioGridi125874. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HBR0.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei36 – 5823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei345 – 36521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0814.
    HOGENOMiHOG000154237.
    HOVERGENiHBG097690.
    InParanoidiQ9HBR0.
    KOiK14996.
    OMAiVVHSRQL.
    OrthoDBiEOG7KM5SR.
    PhylomeDBiQ9HBR0.
    TreeFamiTF320116.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HBR0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTAAAASNWG LITNIVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT     50
    HQSCMFLVKS ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGTCIAF 100
    YVVIGDLGSN FFARLFGFQV GGTFRMFLLF AVSLCIVLPL SLQRNMMASI 150
    QSFSAMALLF YTVFMFVIVL SSLKHGLFSG QWLRRVSYVR WEGVFRCIPI 200
    FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTTF YVMVGFFGYV 250
    SFTEATAGNV LMHFPSNLVT EMLRVGFMMS VAVGFPMMIL PCRQALSTLL 300
    CEQQQKDGTF AAGGYMPPLR FKALTLSVVF GTMVGGILIP NVETILGLTG 350
    ATMGSLICFI CPALIYKKIH KNALSSQVVL WVGLGVLVVS TVTTLSVSEE 400
    VPEDLAEEAP GGRLGEAEGL MKVEAARLSA QDPVVAVAED GREKPKLPKE 450
    REELEQAQIK GPVDVPGRED GKEAPEEAQL DRPGQGIAVP VGEAHRHEPP 500
    VPHDKVVVDE GQDREVPEEN KPPSRHAGGK APGVQGQMAP PLPDSEREKQ 550
    EPEQGEVGKR PGQAQALEEA GDLPEDPQKV PEADGQPAVQ PAKEDLGPGD 600
    RGLHPRPQAV LSEQQNGLAV GGGEKAKGGP PPGNAAGDTG QPAEDSDHGG 650
    KPPLPAEKPA PGPGLPPEPR EQRDVERAGG NQAASQLEEA GRAEMLDHAV 700
    LLQVIKEQQV QQKRLLDQQE KLLAVIEEQH KEIHQQRQED EEDKPRQVEV 750
    HQEPGAAVPR GQEAPEGKAR ETVENLPPLP LDPVLRAPGG RPAPSQDLNQ 800
    RSLEHSEGPV GRDPAGPPDG GPDTEPRAAQ AKLRDGQKDA APRAAGTVKE 850
    LPKGPEQVPV PDPAREAGGP EERLAEEFPG QSQDVTGGSQ DRKKPGKEVA 900
    ATGTSILKEA NWLVAGPGAE TGDPRMKPKQ VSRDLGLAAD LPGGAEGAAA 950
    QPQAVLRQPE LRVISDGEQG GQQGHRLDHG GHLEMRKARG GDHVPVSHEQ 1000
    PRGGEDAAVQ EPRQRPEPEL GLKRAVPGGQ RPDNAKPNRD LKLQAGSDLR 1050
    RRRRDLGPHA EGQLAPRDGV IIGLNPLPDV QVNDLRGALD AQLRQAAGGA 1100
    LQVVHSRQLR QAPGPPEES 1119
    Length:1,119
    Mass (Da):119,762
    Last modified:February 26, 2008 - v2
    Checksum:iF328CFEB6A5336D9
    GO
    Isoform 2 (identifier: Q9HBR0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         689-780: EAGRAEMLDH...ETVENLPPLP → GKASALQPPA...DYRFISLAPL
         781-1119: Missing.

    Show »
    Length:780
    Mass (Da):83,324
    Checksum:iE529A228C8842312
    GO
    Isoform 3 (identifier: Q9HBR0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-82: Missing.
         768-768: K → S
         769-1119: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:686
    Mass (Da):73,978
    Checksum:iF260EB0E42807634
    GO

    Sequence cautioni

    The sequence AAG17235.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC04027.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1071 – 10711Missing in AAG17235. (PubMed:15498874)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti559 – 5591K → R.
    Corresponds to variant rs35546507 [ dbSNP | Ensembl ].
    VAR_048126
    Natural varianti831 – 8311A → G.1 Publication
    Corresponds to variant rs2725405 [ dbSNP | Ensembl ].
    VAR_038927

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8282Missing in isoform 3. 1 PublicationVSP_031323Add
    BLAST
    Alternative sequencei689 – 78092EAGRA…LPPLP → GKASALQPPASGPGSGSPLP QPWGDAQVILGSPARPPFSF QPPAEQTPRRAFCSLPISSL LSGNLLSALLPFKHLRHRHM ACDYRFISLAPL in isoform 2. 2 PublicationsVSP_031324Add
    BLAST
    Alternative sequencei768 – 7681K → S in isoform 3. 1 PublicationVSP_031325
    Alternative sequencei769 – 1119351Missing in isoform 3. 1 PublicationVSP_031326Add
    BLAST
    Alternative sequencei781 – 1119339Missing in isoform 2. 2 PublicationsVSP_031327Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093037 mRNA. Translation: BAC04027.1. Different initiation.
    AK128330 mRNA. Translation: BAC87387.1.
    AC027601 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW89643.1.
    BC014642 mRNA. Translation: AAH14642.1.
    AF217993 mRNA. Translation: AAG17235.1. Different initiation.
    CCDSiCCDS11780.1. [Q9HBR0-2]
    CCDS42397.1. [Q9HBR0-1]
    RefSeqiNP_001033073.1. NM_001037984.2. [Q9HBR0-1]
    NP_612637.1. NM_138570.3. [Q9HBR0-2]
    UniGeneiHs.352240.

    Genome annotation databases

    EnsembliENST00000288439; ENSP00000288439; ENSG00000157637. [Q9HBR0-2]
    ENST00000374759; ENSP00000363891; ENSG00000157637. [Q9HBR0-1]
    GeneIDi124565.
    KEGGihsa:124565.
    UCSCiuc002jzy.1. human. [Q9HBR0-1]
    uc002kab.3. human. [Q9HBR0-2]

    Polymorphism databases

    DMDMi172045932.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093037 mRNA. Translation: BAC04027.1 . Different initiation.
    AK128330 mRNA. Translation: BAC87387.1 .
    AC027601 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW89643.1 .
    BC014642 mRNA. Translation: AAH14642.1 .
    AF217993 mRNA. Translation: AAG17235.1 . Different initiation.
    CCDSi CCDS11780.1. [Q9HBR0-2 ]
    CCDS42397.1. [Q9HBR0-1 ]
    RefSeqi NP_001033073.1. NM_001037984.2. [Q9HBR0-1 ]
    NP_612637.1. NM_138570.3. [Q9HBR0-2 ]
    UniGenei Hs.352240.

    3D structure databases

    ProteinModelPortali Q9HBR0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125874. 1 interaction.

    Protein family/group databases

    TCDBi 2.A.18.6.16. the amino acid/auxin permease (aaap) family.

    PTM databases

    PhosphoSitei Q9HBR0.

    Polymorphism databases

    DMDMi 172045932.

    Proteomic databases

    MaxQBi Q9HBR0.
    PaxDbi Q9HBR0.
    PeptideAtlasi Q9HBR0.
    PRIDEi Q9HBR0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000288439 ; ENSP00000288439 ; ENSG00000157637 . [Q9HBR0-2 ]
    ENST00000374759 ; ENSP00000363891 ; ENSG00000157637 . [Q9HBR0-1 ]
    GeneIDi 124565.
    KEGGi hsa:124565.
    UCSCi uc002jzy.1. human. [Q9HBR0-1 ]
    uc002kab.3. human. [Q9HBR0-2 ]

    Organism-specific databases

    CTDi 124565.
    GeneCardsi GC17M079218.
    HGNCi HGNC:28237. SLC38A10.
    HPAi HPA021374.
    HPA023161.
    HPA024631.
    neXtProti NX_Q9HBR0.
    PharmGKBi PA162403738.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0814.
    HOGENOMi HOG000154237.
    HOVERGENi HBG097690.
    InParanoidi Q9HBR0.
    KOi K14996.
    OMAi VVHSRQL.
    OrthoDBi EOG7KM5SR.
    PhylomeDBi Q9HBR0.
    TreeFami TF320116.

    Miscellaneous databases

    ChiTaRSi SLC38A10. human.
    GeneWikii SLC38A10.
    GenomeRNAii 124565.
    NextBioi 81322.
    PROi Q9HBR0.

    Gene expression databases

    ArrayExpressi Q9HBR0.
    Bgeei Q9HBR0.
    CleanExi HS_SLC38A10.
    Genevestigatori Q9HBR0.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 209-1119 (ISOFORM 2).
      Tissue: Thymus.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Muscle.
    5. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 784-1119, VARIANT GLY-831.

    Entry informationi

    Entry nameiS38AA_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBR0
    Secondary accession number(s): Q6ZRC5, Q8NA99, Q96C66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3