Q9HBM0 (VEZA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vezatin

Gene names

Name:

VEZT

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	779 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. Ref.7
Subunit structure	Interacts with myosin VIIa and the cadherin-catenins complex. Ref.2
Subcellular location	Cell membrane; Multi-pass membrane protein. Cell junction › adherens junction. Nucleus. Cytoplasmic vesicle › secretory vesicle › acrosome By similarity.
Sequence similarities	Belongs to the vezatin family.
Sequence caution	The sequence AAG38514.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part. The sequence AAH64939.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence BAA91634.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence CAB70772.2 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Cytoplasmic vesicle Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell adhesion Inferred from electronic annotation. Source: Compara chordate embryonic development Inferred from electronic annotation. Source: Compara
Cellular_component	acrosomal vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell adherens junction Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell stereocilia ankle link complex Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9HBM0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HBM0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     49-55: PPTRVLP → MLKEWAI
     611-617: AVLKSLS → GVKSAWN
     618-779: Missing.

Note: Due to intron retention.

Isoform 5 (identifier: Q9HBM0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     57-65: QGILLKVAE → GSLSAICLH
     66-779: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 6 (identifier: Q9HBM0-6)

The sequence of this isoform differs from the canonical sequence as follows:
     57-79: QGILLKVAETIKSWIFFSQCNKK → YLGYSNHSMNINCTYWHAQGMGY
     80-779: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 779	779	Vezatin		PRO_0000065783
Regions
	Transmembrane	139 – 159	21	Helical; Potential
	Transmembrane	162 – 182	21	Helical; Potential
	Coiled coil	430 – 462	33	Potential
	Compositional bias	763 – 766	4	Poly-Glu
Natural variations
	Alternative sequence	1 – 48	48	Missing in isoform 2.		VSP_004010
	Alternative sequence	49 – 55	7	PPTRVLP → MLKEWAI in isoform 2.		VSP_004011
	Alternative sequence	57 – 79	23	QGILL…QCNKK → YLGYSNHSMNINCTYWHAQG MGY in isoform 6.		VSP_040853
	Alternative sequence	57 – 65	9	QGILLKVAE → GSLSAICLH in isoform 5.		VSP_040854
	Alternative sequence	66 – 779	714	Missing in isoform 5.		VSP_040855
	Alternative sequence	80 – 779	700	Missing in isoform 6.		VSP_040856
	Alternative sequence	611 – 617	7	AVLKSLS → GVKSAWN in isoform 2.		VSP_004014
	Alternative sequence	618 – 779	162	Missing in isoform 2.		VSP_004017
	Natural variant	162	1	T → A. Corresponds to variant rs17855933 [ dbSNP | Ensembl ].		VAR_046303
	Natural variant	496	1	V → I. Ref.2 Corresponds to variant rs10507051 [ dbSNP | Ensembl ].		VAR_046304
	Natural variant	612	1	V → M. Ref.6 Corresponds to variant rs17344738 [ dbSNP | Ensembl ].		VAR_046305
	Natural variant	668	1	S → A. Corresponds to variant rs17855934 [ dbSNP | Ensembl ].		VAR_046306
	Natural variant	762	1	G → D. Ref.1 Ref.6 Corresponds to variant rs14121 [ dbSNP | Ensembl ].		VAR_014945
Experimental info
	Sequence conflict	46	1	Q → R in BAA91634. Ref.3
	Sequence conflict	169	1	W → R in AAG38485. Ref.2
	Sequence conflict	334	1	L → W in AAG09719. Ref.1
	Sequence conflict	396	1	Y → I in AAG09719. Ref.1
	Sequence conflict	432	1	S → T in AAG09719. Ref.1
	Sequence conflict	617	1	S → F in AAG09719. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 3, 2009. Version 3. Checksum: 4B59BBAA491A71A5	FASTA	779	88,665
	10 20 30 40 50 60 MTPEFDEEVV FENSPLYQYL QDLGHTDFEI CSSLSPKTEK CTTEGQQKPP TRVLPKQGIL 70 80 90 100 110 120 LKVAETIKSW IFFSQCNKKD DLLHKLDIGF RLDSLHTILQ QEVLLQEDVE LIELLDPSIL 130 140 150 160 170 180 SAGQSQQQEN GHLPTLCSLA TPNIWDLSML FAFISLLVML PTWWIVSSWL VWGVILFVYL 190 200 210 220 230 240 VIRALRLWRT AKLQVTLKKY SVHLEDMATN SRAFTNLVRK ALRLIQETEV ISRGFTLVSA 250 260 270 280 290 300 ACPFNKAGQH PSQHLIGLRK AVYRTLRANF QAARLATLYM LKNYPLNSES DNVTNYICVV 310 320 330 340 350 360 PFKELGLGLS EEQISEEEAH NFTDGFSLPA LKVLFQLWVA QSSEFFRRLA LLLSTANSPP 370 380 390 400 410 420 GPLLTPALLP HRILSDVTQG LPHAHSACLE ELKRSYEFYR YFETQHQSVP QCLSKTQQKS 430 440 450 460 470 480 RELNNVHTAV RSLQLHLKAL LNEVIILEDE LEKLVCTKET QELVSEAYPI LEQKLKLIQP 490 500 510 520 530 540 HVQASNNCWE EAISQVDKLL RRNTDKKGKP EIACENPHCT VVPLKQPTLH IADKDPIPEE 550 560 570 580 590 600 QELEAYVDDI DIDSDFRKDD FYYLSQEDKE RQKREHEESK RVLQELKSVL GFKASEAERQ 610 620 630 640 650 660 KWKQLLFSDH AVLKSLSPVD PVEPISNSEP SMNSDMGKVS KNDTEEESNK SATTDNEISR 670 680 690 700 710 720 TEYLCENSLE GKNKDNSSNE VFPQGAEERM CYQCESEDEP QADGSGLTTA PPTPRDSLQP 730 740 750 760 770 SIKQRLARLQ LSPDFTFTAG LAAEVAARSL SFTTMQEQTF GGEEEEQIIE ENKNEIEEK
	Isoform 2 [UniParc]. Checksum: 22A06379729FAB16	FASTA	569	65,424
	10 20 30 40 50 60 MLKEWAIKQG ILLKVAETIK SWIFFSQCNK KDDLLHKLDI GFRLDSLHTI LQQEVLLQED 70 80 90 100 110 120 VELIELLDPS ILSAGQSQQQ ENGHLPTLCS LATPNIWDLS MLFAFISLLV MLPTWWIVSS 130 140 150 160 170 180 WLVWGVILFV YLVIRALRLW RTAKLQVTLK KYSVHLEDMA TNSRAFTNLV RKALRLIQET 190 200 210 220 230 240 EVISRGFTLV SAACPFNKAG QHPSQHLIGL RKAVYRTLRA NFQAARLATL YMLKNYPLNS 250 260 270 280 290 300 ESDNVTNYIC VVPFKELGLG LSEEQISEEE AHNFTDGFSL PALKVLFQLW VAQSSEFFRR 310 320 330 340 350 360 LALLLSTANS PPGPLLTPAL LPHRILSDVT QGLPHAHSAC LEELKRSYEF YRYFETQHQS 370 380 390 400 410 420 VPQCLSKTQQ KSRELNNVHT AVRSLQLHLK ALLNEVIILE DELEKLVCTK ETQELVSEAY 430 440 450 460 470 480 PILEQKLKLI QPHVQASNNC WEEAISQVDK LLRRNTDKKG KPEIACENPH CTVVPLKQPT 490 500 510 520 530 540 LHIADKDPIP EEQELEAYVD DIDIDSDFRK DDFYYLSQED KERQKREHEE SKRVLQELKS 550 560 VLGFKASEAE RQKWKQLLFS DHGVKSAWN
	Isoform 5 [UniParc]. Checksum: 94071F7D3D93001A	FASTA	65	7,315
	10 20 30 40 50 60 MTPEFDEEVV FENSPLYQYL QDLGHTDFEI CSSLSPKTEK CTTEGQQKPP TRVLPKGSLS AICLH
	Isoform 6 [UniParc]. Checksum: 23C6D52B54707F19	FASTA	79	9,126
	10 20 30 40 50 60 MTPEFDEEVV FENSPLYQYL QDLGHTDFEI CSSLSPKTEK CTTEGQQKPP TRVLPKYLGY 70 SNHSMNINCT YWHAQGMGY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Xiao H., Song H., Gao G., Ren S., Chen Z., Han Z. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-762. Tissue: Adrenal gland.
[2]	"Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex." Kuessel-Andermann P., El-Amraoui A., Safieddine S., Nouaille S., Perfettini I., Lecuit M., Cossart P., Wolfrum U., Petit C. EMBO J. 19:6020-6029(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBUNIT, VARIANT ILE-496. Tissue: Retina.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[4]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Skin.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-610 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 391-779 (ISOFORM 1), VARIANTS MET-612 AND ASP-762. Tissue: Amygdala and Testis.
[7]	"Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells." Sousa S., Cabanes D., El-Amraoui A., Petit C., Lecuit M., Cossart P. J. Cell Sci. 117:2121-2130(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF225417 mRNA. Translation: AAG09719.1. AF216644 mRNA. Translation: AAG38485.1. AF277625 mRNA. Translation: AAG38514.1. Sequence problems. AK001338 mRNA. Translation: BAA91634.1. Sequence problems. AC084879 Genomic DNA. No translation available. AC127165 Genomic DNA. No translation available. BC064939 mRNA. Translation: AAH64939.1. Sequence problems. AL133113 mRNA. Translation: CAB61416.1. AL137497 mRNA. Translation: CAB70772.2. Sequence problems.
IPI	IPI00029954. IPI00218140. IPI00218143. IPI00480160.
PIR	T46251.
RefSeq	NP_060069.3. NM_017599.3.
UniGene	Hs.24135.
3D structure databases
ProteinModelPortal	Q9HBM0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000410083.
Polymorphism databases
DMDM	224471870.
Proteomic databases
PaxDb	Q9HBM0.
PRIDE	Q9HBM0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000436874; ENSP00000410083; ENSG00000028203. ENST00000546557; ENSP00000447080; ENSG00000028203. ENST00000547484; ENSP00000447010; ENSG00000028203. ENST00000547997; ENSP00000449346; ENSG00000028203. ENST00000548455; ENSP00000447044; ENSG00000028203. ENST00000549624; ENSP00000448555; ENSG00000028203. ENST00000550803; ENSP00000449056; ENSG00000028203. ENST00000552660; ENSP00000447786; ENSG00000028203.
GeneID	55591.
KEGG	hsa:55591.
UCSC	uc001tdz.2. human.
Organism-specific databases
CTD	55591.
GeneCards	GC12P095611.
H-InvDB	HIX0021238.
HGNC	HGNC:18258. VEZT.
HPA	HPA004811. HPA017066.
neXtProt	NX_Q9HBM0.
PharmGKB	PA143485667.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG67649.
HOVERGEN	HBG108656.
InParanoid	Q9HBM0.
OMA	QPSIKQR.
OrthoDB	EOG4HDST6.
Gene expression databases
ArrayExpress	Q9HBM0.
Bgee	Q9HBM0.
CleanEx	HS_VEZT.
Genevestigator	Q9HBM0.
GermOnline	ENSG00000028203. Homo sapiens.
Family and domain databases
InterPro	IPR026859. Myosin-bd. IPR026858. Vezatin. [Graphical view]
PANTHER	PTHR15989. PTHR15989. 1 hit.
Pfam	PF12632. Vezatin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	VEZT. human.
GenomeRNAi	55591.
NextBio	60118.

Entry information

Entry name

VEZA_HUMAN

Accession

Primary (citable) accession number: Q9HBM0
Secondary accession number(s): Q6P1Q3 , Q9H2F4, Q9H2U5, Q9NT70, Q9NVW0, Q9UF91

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	March 3, 2009
Last modified:	April 3, 2013
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.