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Q9HBM0 (VEZA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vezatin
Gene names
Name:VEZT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length779 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. Ref.7

Subunit structure

Interacts with myosin VIIa and the cadherin-catenins complex. Ref.2

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctionadherens junction. Nucleus. Cytoplasmic vesiclesecretory vesicleacrosome By similarity.

Sequence similarities

Belongs to the vezatin family.

Sequence caution

The sequence AAG38514.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

The sequence AAH64939.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

The sequence BAA91634.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

The sequence CAB70772.2 differs from that shown. Reason: Intron retention.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9HBM0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HBM0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     49-55: PPTRVLP → MLKEWAI
     611-617: AVLKSLS → GVKSAWN
     618-779: Missing.
Note: Due to intron retention.
Isoform 5 (identifier: Q9HBM0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     57-65: QGILLKVAE → GSLSAICLH
     66-779: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 6 (identifier: Q9HBM0-6)

The sequence of this isoform differs from the canonical sequence as follows:
     57-79: QGILLKVAETIKSWIFFSQCNKK → YLGYSNHSMNINCTYWHAQGMGY
     80-779: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 779779Vezatin
PRO_0000065783

Regions

Transmembrane139 – 15921Helical; Potential
Transmembrane162 – 18221Helical; Potential
Coiled coil430 – 46233 Potential
Compositional bias763 – 7664Poly-Glu

Natural variations

Alternative sequence1 – 4848Missing in isoform 2.
VSP_004010
Alternative sequence49 – 557PPTRVLP → MLKEWAI in isoform 2.
VSP_004011
Alternative sequence57 – 7923QGILL…QCNKK → YLGYSNHSMNINCTYWHAQG MGY in isoform 6.
VSP_040853
Alternative sequence57 – 659QGILLKVAE → GSLSAICLH in isoform 5.
VSP_040854
Alternative sequence66 – 779714Missing in isoform 5.
VSP_040855
Alternative sequence80 – 779700Missing in isoform 6.
VSP_040856
Alternative sequence611 – 6177AVLKSLS → GVKSAWN in isoform 2.
VSP_004014
Alternative sequence618 – 779162Missing in isoform 2.
VSP_004017
Natural variant1621T → A.
Corresponds to variant rs17855933 [ dbSNP | Ensembl ].
VAR_046303
Natural variant4961V → I. Ref.2
Corresponds to variant rs10507051 [ dbSNP | Ensembl ].
VAR_046304
Natural variant6121V → M. Ref.6
Corresponds to variant rs17344738 [ dbSNP | Ensembl ].
VAR_046305
Natural variant6681S → A.
Corresponds to variant rs17855934 [ dbSNP | Ensembl ].
VAR_046306
Natural variant7621G → D. Ref.1 Ref.6
Corresponds to variant rs14121 [ dbSNP | Ensembl ].
VAR_014945

Experimental info

Sequence conflict461Q → R in BAA91634. Ref.3
Sequence conflict1691W → R in AAG38485. Ref.2
Sequence conflict3341L → W in AAG09719. Ref.1
Sequence conflict3961Y → I in AAG09719. Ref.1
Sequence conflict4321S → T in AAG09719. Ref.1
Sequence conflict6171S → F in AAG09719. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 3, 2009. Version 3.
Checksum: 4B59BBAA491A71A5

FASTA77988,665
        10         20         30         40         50         60 
MTPEFDEEVV FENSPLYQYL QDLGHTDFEI CSSLSPKTEK CTTEGQQKPP TRVLPKQGIL 

        70         80         90        100        110        120 
LKVAETIKSW IFFSQCNKKD DLLHKLDIGF RLDSLHTILQ QEVLLQEDVE LIELLDPSIL 

       130        140        150        160        170        180 
SAGQSQQQEN GHLPTLCSLA TPNIWDLSML FAFISLLVML PTWWIVSSWL VWGVILFVYL 

       190        200        210        220        230        240 
VIRALRLWRT AKLQVTLKKY SVHLEDMATN SRAFTNLVRK ALRLIQETEV ISRGFTLVSA 

       250        260        270        280        290        300 
ACPFNKAGQH PSQHLIGLRK AVYRTLRANF QAARLATLYM LKNYPLNSES DNVTNYICVV 

       310        320        330        340        350        360 
PFKELGLGLS EEQISEEEAH NFTDGFSLPA LKVLFQLWVA QSSEFFRRLA LLLSTANSPP 

       370        380        390        400        410        420 
GPLLTPALLP HRILSDVTQG LPHAHSACLE ELKRSYEFYR YFETQHQSVP QCLSKTQQKS 

       430        440        450        460        470        480 
RELNNVHTAV RSLQLHLKAL LNEVIILEDE LEKLVCTKET QELVSEAYPI LEQKLKLIQP 

       490        500        510        520        530        540 
HVQASNNCWE EAISQVDKLL RRNTDKKGKP EIACENPHCT VVPLKQPTLH IADKDPIPEE 

       550        560        570        580        590        600 
QELEAYVDDI DIDSDFRKDD FYYLSQEDKE RQKREHEESK RVLQELKSVL GFKASEAERQ 

       610        620        630        640        650        660 
KWKQLLFSDH AVLKSLSPVD PVEPISNSEP SMNSDMGKVS KNDTEEESNK SATTDNEISR 

       670        680        690        700        710        720 
TEYLCENSLE GKNKDNSSNE VFPQGAEERM CYQCESEDEP QADGSGLTTA PPTPRDSLQP 

       730        740        750        760        770 
SIKQRLARLQ LSPDFTFTAG LAAEVAARSL SFTTMQEQTF GGEEEEQIIE ENKNEIEEK 

« Hide

Isoform 2 [UniParc].

Checksum: 22A06379729FAB16
Show »

FASTA56965,424
Isoform 5 [UniParc].

Checksum: 94071F7D3D93001A
Show »

FASTA657,315
Isoform 6 [UniParc].

Checksum: 23C6D52B54707F19
Show »

FASTA799,126

References

« Hide 'large scale' references
[1]Xiao H., Song H., Gao G., Ren S., Chen Z., Han Z.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-762.
Tissue: Adrenal gland.
[2]"Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex."
Kuessel-Andermann P., El-Amraoui A., Safieddine S., Nouaille S., Perfettini I., Lecuit M., Cossart P., Wolfrum U., Petit C.
EMBO J. 19:6020-6029(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBUNIT, VARIANT ILE-496.
Tissue: Retina.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[4]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
Tissue: Skin.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-610 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 391-779 (ISOFORM 1), VARIANTS MET-612 AND ASP-762.
Tissue: Amygdala and Testis.
[7]"Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells."
Sousa S., Cabanes D., El-Amraoui A., Petit C., Lecuit M., Cossart P.
J. Cell Sci. 117:2121-2130(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF225417 mRNA. Translation: AAG09719.1.
AF216644 mRNA. Translation: AAG38485.1.
AF277625 mRNA. Translation: AAG38514.1. Sequence problems.
AK001338 mRNA. Translation: BAA91634.1. Sequence problems.
AC084879 Genomic DNA. No translation available.
AC127165 Genomic DNA. No translation available.
BC064939 mRNA. Translation: AAH64939.1. Sequence problems.
AL133113 mRNA. Translation: CAB61416.1.
AL137497 mRNA. Translation: CAB70772.2. Sequence problems.
PIRT46251.
RefSeqNP_060069.3. NM_017599.3.
UniGeneHs.24135.

3D structure databases

ProteinModelPortalQ9HBM0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120736. 6 interactions.
STRING9606.ENSP00000410083.

Polymorphism databases

DMDM224471870.

Proteomic databases

PaxDbQ9HBM0.
PRIDEQ9HBM0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000436874; ENSP00000410083; ENSG00000028203. [Q9HBM0-1]
ENST00000546557; ENSP00000447080; ENSG00000028203. [Q9HBM0-6]
ENST00000547484; ENSP00000447010; ENSG00000028203. [Q9HBM0-6]
ENST00000547997; ENSP00000449346; ENSG00000028203. [Q9HBM0-6]
ENST00000548455; ENSP00000447044; ENSG00000028203. [Q9HBM0-6]
ENST00000549624; ENSP00000448555; ENSG00000028203. [Q9HBM0-6]
ENST00000550803; ENSP00000449056; ENSG00000028203. [Q9HBM0-6]
ENST00000552660; ENSP00000447786; ENSG00000028203. [Q9HBM0-6]
GeneID55591.
KEGGhsa:55591.
UCSCuc001tdz.2. human. [Q9HBM0-1]

Organism-specific databases

CTD55591.
GeneCardsGC12P095611.
H-InvDBHIX0021238.
HGNCHGNC:18258. VEZT.
HPAHPA004811.
HPA017066.
neXtProtNX_Q9HBM0.
PharmGKBPA143485667.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG67649.
HOVERGENHBG108656.
InParanoidQ9HBM0.
OMADMDSDFR.
OrthoDBEOG7X6KZN.
PhylomeDBQ9HBM0.
TreeFamTF332269.

Gene expression databases

ArrayExpressQ9HBM0.
BgeeQ9HBM0.
CleanExHS_VEZT.
GenevestigatorQ9HBM0.

Family and domain databases

InterProIPR026859. Myosin-bd.
IPR026858. Vezatin.
[Graphical view]
PANTHERPTHR15989. PTHR15989. 1 hit.
PfamPF12632. Vezatin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSVEZT. human.
GeneWikiVEZT.
GenomeRNAi55591.
NextBio60118.
PROQ9HBM0.

Entry information

Entry nameVEZA_HUMAN
AccessionPrimary (citable) accession number: Q9HBM0
Secondary accession number(s): Q6P1Q3 expand/collapse secondary AC list , Q9H2F4, Q9H2U5, Q9NT70, Q9NVW0, Q9UF91
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM