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Protein

Plasminogen receptor (KT)

Gene

PLGRKT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Chemotaxis, Inflammatory response, Plasminogen activation

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen receptor (KT)
Short name:
Plg-R(KT)
Gene namesi
Name:PLGRKT
Synonyms:C9orf46
ORF Names:AD025, MDS030
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23633. PLGRKT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularSequence analysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Topological domaini74 – 785CytoplasmicSequence analysis
Transmembranei79 – 9921HelicalSequence analysisAdd
BLAST
Topological domaini100 – 14748ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134964114.

Polymorphism and mutation databases

BioMutaiPLGRKT.
DMDMi68565305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Plasminogen receptor (KT)PRO_0000089695Add
BLAST

Proteomic databases

EPDiQ9HBL7.
MaxQBiQ9HBL7.
PaxDbiQ9HBL7.
PeptideAtlasiQ9HBL7.
PRIDEiQ9HBL7.
TopDownProteomicsiQ9HBL7.

PTM databases

iPTMnetiQ9HBL7.
PhosphoSiteiQ9HBL7.

Expressioni

Tissue specificityi

Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla.2 Publications

Gene expression databases

BgeeiQ9HBL7.
CleanExiHS_C9orf46.
GenevisibleiQ9HBL7. HS.

Organism-specific databases

HPAiHPA008214.
HPA011144.

Interactioni

Subunit structurei

Interacts with PLAT and PLAUR.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EEF1GP26641-23EBI-714824,EBI-10177695

Protein-protein interaction databases

BioGridi120950. 5 interactions.
IntActiQ9HBL7. 6 interactions.
MINTiMINT-1401294.
STRINGi9606.ENSP00000223864.

Structurei

3D structure databases

ProteinModelPortaliQ9HBL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4544. Eukaryota.
ENOG4111K7G. LUCA.
GeneTreeiENSGT00390000000375.
HOGENOMiHOG000007140.
HOVERGENiHBG081159.
InParanoidiQ9HBL7.
OMAiMQNEMRE.
OrthoDBiEOG7DJSPJ.
PhylomeDBiQ9HBL7.
TreeFamiTF314698.

Family and domain databases

InterProiIPR019319. DUF2368.
[Graphical view]
PANTHERiPTHR13411. PTHR13411. 1 hit.
PfamiPF10166. DUF2368. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HBL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFIFSKSMN ESMKNQKEFM LMNARLQLER QLIMQSEMRE RQMAMQIAWS
60 70 80 90 100
REFLKYFGTF FGLAAISLTA GAIKKKKPAF LVPIVPLSFI LTYQYDLGYG
110 120 130 140
TLLERMKGEA EDILETEKSK LQLPRGMITF ESIEKARKEQ SRFFIDK
Length:147
Mass (Da):17,201
Last modified:March 1, 2001 - v1
Checksum:iBF096D76E8F2F806
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461Q → R in AAF67643 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225420 mRNA. Translation: AAG09722.1.
AF220050 mRNA. Translation: AAF67643.1.
AK027594 mRNA. Translation: BAB55219.1.
AK312736 mRNA. Translation: BAG35607.1.
AL135786 Genomic DNA. Translation: CAH70364.1.
CH471071 Genomic DNA. Translation: EAW58765.1.
BC008212 mRNA. Translation: AAH08212.1.
CCDSiCCDS6463.1.
RefSeqiNP_060935.2. NM_018465.3.
XP_005251567.1. XM_005251510.3.
XP_011516262.1. XM_011517960.1.
UniGeneiHs.584242.

Genome annotation databases

EnsembliENST00000223864; ENSP00000223864; ENSG00000107020.
GeneIDi55848.
KEGGihsa:55848.
UCSCiuc003zjc.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225420 mRNA. Translation: AAG09722.1.
AF220050 mRNA. Translation: AAF67643.1.
AK027594 mRNA. Translation: BAB55219.1.
AK312736 mRNA. Translation: BAG35607.1.
AL135786 Genomic DNA. Translation: CAH70364.1.
CH471071 Genomic DNA. Translation: EAW58765.1.
BC008212 mRNA. Translation: AAH08212.1.
CCDSiCCDS6463.1.
RefSeqiNP_060935.2. NM_018465.3.
XP_005251567.1. XM_005251510.3.
XP_011516262.1. XM_011517960.1.
UniGeneiHs.584242.

3D structure databases

ProteinModelPortaliQ9HBL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120950. 5 interactions.
IntActiQ9HBL7. 6 interactions.
MINTiMINT-1401294.
STRINGi9606.ENSP00000223864.

PTM databases

iPTMnetiQ9HBL7.
PhosphoSiteiQ9HBL7.

Polymorphism and mutation databases

BioMutaiPLGRKT.
DMDMi68565305.

Proteomic databases

EPDiQ9HBL7.
MaxQBiQ9HBL7.
PaxDbiQ9HBL7.
PeptideAtlasiQ9HBL7.
PRIDEiQ9HBL7.
TopDownProteomicsiQ9HBL7.

Protocols and materials databases

DNASUi55848.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223864; ENSP00000223864; ENSG00000107020.
GeneIDi55848.
KEGGihsa:55848.
UCSCiuc003zjc.5. human.

Organism-specific databases

CTDi55848.
GeneCardsiPLGRKT.
H-InvDBHIX0007899.
HGNCiHGNC:23633. PLGRKT.
HPAiHPA008214.
HPA011144.
neXtProtiNX_Q9HBL7.
PharmGKBiPA134964114.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4544. Eukaryota.
ENOG4111K7G. LUCA.
GeneTreeiENSGT00390000000375.
HOGENOMiHOG000007140.
HOVERGENiHBG081159.
InParanoidiQ9HBL7.
OMAiMQNEMRE.
OrthoDBiEOG7DJSPJ.
PhylomeDBiQ9HBL7.
TreeFamiTF314698.

Miscellaneous databases

GenomeRNAii55848.
PROiQ9HBL7.

Gene expression databases

BgeeiQ9HBL7.
CleanExiHS_C9orf46.
GenevisibleiQ9HBL7. HS.

Family and domain databases

InterProiIPR019319. DUF2368.
[Graphical view]
PANTHERiPTHR13411. PTHR13411. 1 hit.
PfamiPF10166. DUF2368. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  2. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
    Zhao M., Gu J., Li N., Peng Y., Han Z., Chen Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hematopoietic stem cell.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Teratocarcinoma.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT."
    Lighvani S., Baik N., Diggs J.E., Khaldoyanidi S., Parmer R.J., Miles L.A.
    Blood 118:5622-5630(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN INFLAMMATORY RESPONSE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release."
    Bai H., Baik N., Kiosses W.B., Krajewski S., Miles L.A., Parmer R.J.
    J. Biol. Chem. 286:33125-33133(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPLRKT_HUMAN
AccessioniPrimary (citable) accession number: Q9HBL7
Secondary accession number(s): B2R6W0, Q9NZ44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.