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Protein

Plasminogen receptor (KT)

Gene

PLGRKT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Chemotaxis, Inflammatory response, Plasminogen activation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107020-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen receptor (KT)
Short name:
Plg-R(KT)
Gene namesi
Name:PLGRKT
Synonyms:C9orf46
ORF Names:AD025, MDS030
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23633. PLGRKT.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularSequence analysisAdd BLAST52
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 78CytoplasmicSequence analysis5
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 147ExtracellularSequence analysisAdd BLAST48

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55848.
OpenTargetsiENSG00000107020.
PharmGKBiPA134964114.

Polymorphism and mutation databases

BioMutaiPLGRKT.
DMDMi68565305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000896951 – 147Plasminogen receptor (KT)Add BLAST147

Proteomic databases

EPDiQ9HBL7.
MaxQBiQ9HBL7.
PaxDbiQ9HBL7.
PeptideAtlasiQ9HBL7.
PRIDEiQ9HBL7.
TopDownProteomicsiQ9HBL7.

PTM databases

iPTMnetiQ9HBL7.
PhosphoSitePlusiQ9HBL7.

Expressioni

Tissue specificityi

Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla.2 Publications

Gene expression databases

BgeeiENSG00000107020.
CleanExiHS_C9orf46.
GenevisibleiQ9HBL7. HS.

Organism-specific databases

HPAiHPA008214.
HPA011144.

Interactioni

Subunit structurei

Interacts with PLAT and PLAUR.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EEF1GP26641-23EBI-714824,EBI-10177695

Protein-protein interaction databases

BioGridi120950. 5 interactors.
IntActiQ9HBL7. 6 interactors.
MINTiMINT-1401294.
STRINGi9606.ENSP00000223864.

Structurei

3D structure databases

ProteinModelPortaliQ9HBL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4544. Eukaryota.
ENOG4111K7G. LUCA.
GeneTreeiENSGT00390000000375.
HOGENOMiHOG000007140.
HOVERGENiHBG081159.
InParanoidiQ9HBL7.
OMAiMQNEMRE.
OrthoDBiEOG091G0RJ6.
PhylomeDBiQ9HBL7.
TreeFamiTF314698.

Family and domain databases

InterProiIPR019319. DUF2368.
[Graphical view]
PANTHERiPTHR13411. PTHR13411. 1 hit.
PfamiPF10166. DUF2368. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HBL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFIFSKSMN ESMKNQKEFM LMNARLQLER QLIMQSEMRE RQMAMQIAWS
60 70 80 90 100
REFLKYFGTF FGLAAISLTA GAIKKKKPAF LVPIVPLSFI LTYQYDLGYG
110 120 130 140
TLLERMKGEA EDILETEKSK LQLPRGMITF ESIEKARKEQ SRFFIDK
Length:147
Mass (Da):17,201
Last modified:March 1, 2001 - v1
Checksum:iBF096D76E8F2F806
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46Q → R in AAF67643 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225420 mRNA. Translation: AAG09722.1.
AF220050 mRNA. Translation: AAF67643.1.
AK027594 mRNA. Translation: BAB55219.1.
AK312736 mRNA. Translation: BAG35607.1.
AL135786 Genomic DNA. Translation: CAH70364.1.
CH471071 Genomic DNA. Translation: EAW58765.1.
BC008212 mRNA. Translation: AAH08212.1.
CCDSiCCDS6463.1.
RefSeqiNP_060935.2. NM_018465.3.
XP_005251567.1. XM_005251510.4.
XP_011516262.1. XM_011517960.2.
UniGeneiHs.584242.

Genome annotation databases

EnsembliENST00000223864; ENSP00000223864; ENSG00000107020.
GeneIDi55848.
KEGGihsa:55848.
UCSCiuc003zjc.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225420 mRNA. Translation: AAG09722.1.
AF220050 mRNA. Translation: AAF67643.1.
AK027594 mRNA. Translation: BAB55219.1.
AK312736 mRNA. Translation: BAG35607.1.
AL135786 Genomic DNA. Translation: CAH70364.1.
CH471071 Genomic DNA. Translation: EAW58765.1.
BC008212 mRNA. Translation: AAH08212.1.
CCDSiCCDS6463.1.
RefSeqiNP_060935.2. NM_018465.3.
XP_005251567.1. XM_005251510.4.
XP_011516262.1. XM_011517960.2.
UniGeneiHs.584242.

3D structure databases

ProteinModelPortaliQ9HBL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120950. 5 interactors.
IntActiQ9HBL7. 6 interactors.
MINTiMINT-1401294.
STRINGi9606.ENSP00000223864.

PTM databases

iPTMnetiQ9HBL7.
PhosphoSitePlusiQ9HBL7.

Polymorphism and mutation databases

BioMutaiPLGRKT.
DMDMi68565305.

Proteomic databases

EPDiQ9HBL7.
MaxQBiQ9HBL7.
PaxDbiQ9HBL7.
PeptideAtlasiQ9HBL7.
PRIDEiQ9HBL7.
TopDownProteomicsiQ9HBL7.

Protocols and materials databases

DNASUi55848.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223864; ENSP00000223864; ENSG00000107020.
GeneIDi55848.
KEGGihsa:55848.
UCSCiuc003zjc.5. human.

Organism-specific databases

CTDi55848.
DisGeNETi55848.
GeneCardsiPLGRKT.
H-InvDBHIX0007899.
HGNCiHGNC:23633. PLGRKT.
HPAiHPA008214.
HPA011144.
neXtProtiNX_Q9HBL7.
OpenTargetsiENSG00000107020.
PharmGKBiPA134964114.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4544. Eukaryota.
ENOG4111K7G. LUCA.
GeneTreeiENSGT00390000000375.
HOGENOMiHOG000007140.
HOVERGENiHBG081159.
InParanoidiQ9HBL7.
OMAiMQNEMRE.
OrthoDBiEOG091G0RJ6.
PhylomeDBiQ9HBL7.
TreeFamiTF314698.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107020-MONOMER.

Miscellaneous databases

GenomeRNAii55848.
PROiQ9HBL7.

Gene expression databases

BgeeiENSG00000107020.
CleanExiHS_C9orf46.
GenevisibleiQ9HBL7. HS.

Family and domain databases

InterProiIPR019319. DUF2368.
[Graphical view]
PANTHERiPTHR13411. PTHR13411. 1 hit.
PfamiPF10166. DUF2368. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLRKT_HUMAN
AccessioniPrimary (citable) accession number: Q9HBL7
Secondary accession number(s): B2R6W0, Q9NZ44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.