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Protein

Plasminogen receptor (KT)

Gene

PLGRKT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9.1 Publication

GO - Biological processi

Keywordsi

Biological processChemotaxis, Inflammatory response, Plasminogen activation

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen receptor (KT)
Short name:
Plg-R(KT)
Gene namesi
Name:PLGRKT
Synonyms:C9orf46
ORF Names:AD025, MDS030
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107020.9
HGNCiHGNC:23633 PLGRKT
neXtProtiNX_Q9HBL7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularSequence analysisAdd BLAST52
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 78CytoplasmicSequence analysis5
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 147ExtracellularSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55848
OpenTargetsiENSG00000107020
PharmGKBiPA134964114

Polymorphism and mutation databases

BioMutaiPLGRKT
DMDMi68565305

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000896951 – 147Plasminogen receptor (KT)Add BLAST147

Proteomic databases

EPDiQ9HBL7
MaxQBiQ9HBL7
PaxDbiQ9HBL7
PeptideAtlasiQ9HBL7
PRIDEiQ9HBL7
TopDownProteomicsiQ9HBL7

PTM databases

iPTMnetiQ9HBL7
PhosphoSitePlusiQ9HBL7

Expressioni

Tissue specificityi

Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla.2 Publications

Gene expression databases

BgeeiENSG00000107020
CleanExiHS_C9orf46
GenevisibleiQ9HBL7 HS

Organism-specific databases

HPAiHPA008214
HPA011144

Interactioni

Subunit structurei

Interacts with PLAT and PLAUR.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EEF1GP26641-23EBI-714824,EBI-10177695

Protein-protein interaction databases

BioGridi120950, 5 interactors
IntActiQ9HBL7, 6 interactors
STRINGi9606.ENSP00000223864

Structurei

3D structure databases

ProteinModelPortaliQ9HBL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4544 Eukaryota
ENOG4111K7G LUCA
GeneTreeiENSGT00390000000375
HOGENOMiHOG000007140
HOVERGENiHBG081159
InParanoidiQ9HBL7
OMAiMQNEMRE
OrthoDBiEOG091G0RJ6
PhylomeDBiQ9HBL7
TreeFamiTF314698

Family and domain databases

InterProiView protein in InterPro
IPR019319 DUF2368
PANTHERiPTHR13411 PTHR13411, 1 hit
PfamiView protein in Pfam
PF10166 DUF2368, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HBL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFIFSKSMN ESMKNQKEFM LMNARLQLER QLIMQSEMRE RQMAMQIAWS
60 70 80 90 100
REFLKYFGTF FGLAAISLTA GAIKKKKPAF LVPIVPLSFI LTYQYDLGYG
110 120 130 140
TLLERMKGEA EDILETEKSK LQLPRGMITF ESIEKARKEQ SRFFIDK
Length:147
Mass (Da):17,201
Last modified:March 1, 2001 - v1
Checksum:iBF096D76E8F2F806
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46Q → R in AAF67643 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225420 mRNA Translation: AAG09722.1
AF220050 mRNA Translation: AAF67643.1
AK027594 mRNA Translation: BAB55219.1
AK312736 mRNA Translation: BAG35607.1
AL135786 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58765.1
BC008212 mRNA Translation: AAH08212.1
CCDSiCCDS6463.1
RefSeqiNP_060935.2, NM_018465.3
XP_005251567.1, XM_005251510.4
XP_011516262.1, XM_011517960.2
UniGeneiHs.584242

Genome annotation databases

EnsembliENST00000223864; ENSP00000223864; ENSG00000107020
GeneIDi55848
KEGGihsa:55848
UCSCiuc003zjc.5 human

Similar proteinsi

Entry informationi

Entry nameiPLRKT_HUMAN
AccessioniPrimary (citable) accession number: Q9HBL7
Secondary accession number(s): B2R6W0, Q9NZ44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health