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Protein

Tensin-1

Gene

TNS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

SignaLinkiQ9HBL0.

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-1
Gene namesi
Name:TNS1
Synonyms:TNS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11973. TNS1.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • focal adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36660.

Polymorphism and mutation databases

BioMutaiTNS1.
DMDMi212276466.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17351735Tensin-1PRO_0000215900Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei338 – 3381PhosphoserineCombined sources
Modified residuei364 – 3641PhosphoserineCombined sources
Modified residuei366 – 3661PhosphotyrosineCombined sources
Modified residuei378 – 3781PhosphoserineCombined sources
Modified residuei379 – 3791PhosphothreonineCombined sources
Modified residuei433 – 4331PhosphoserineCombined sources
Modified residuei621 – 6211PhosphoserineCombined sources
Modified residuei701 – 7011PhosphoserineCombined sources
Modified residuei764 – 7641PhosphoserineCombined sources
Modified residuei769 – 7691PhosphoserineCombined sources
Modified residuei794 – 7941PhosphoserineCombined sources
Modified residuei860 – 8601PhosphothreonineCombined sources
Modified residuei899 – 8991PhosphoserineCombined sources
Modified residuei903 – 9031PhosphotyrosineCombined sources
Modified residuei907 – 9071PhosphoserineCombined sources
Modified residuei963 – 9631PhosphoserineCombined sources
Modified residuei967 – 9671PhosphoserineCombined sources
Modified residuei1124 – 11241PhosphoserineCombined sources
Modified residuei1177 – 11771PhosphoserineCombined sources1 Publication
Modified residuei1189 – 11891Phosphothreonine; in variant Arg-1197Combined sources
Modified residuei1192 – 11921Phosphoserine; in variant Arg-1197Combined sources
Modified residuei1266 – 12661PhosphothreonineCombined sources
Modified residuei1269 – 12691PhosphoserineCombined sources
Modified residuei1294 – 12941PhosphoserineCombined sources
Modified residuei1309 – 13091PhosphoserineCombined sources
Modified residuei1314 – 13141PhosphoserineCombined sources
Modified residuei1381 – 13811PhosphoserineCombined sources
Modified residuei1393 – 13931PhosphoserineCombined sources
Modified residuei1400 – 14001PhosphoserineCombined sources
Modified residuei1446 – 14461PhosphoserineCombined sources
Modified residuei1588 – 15881PhosphoserineCombined sources

Post-translational modificationi

Rapidly cleaved by calpain II.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HBL0.
MaxQBiQ9HBL0.
PaxDbiQ9HBL0.
PeptideAtlasiQ9HBL0.
PRIDEiQ9HBL0.

PTM databases

DEPODiQ9HBL0.
iPTMnetiQ9HBL0.
PhosphoSiteiQ9HBL0.

Miscellaneous databases

PMAP-CutDBQ9HBL0.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000079308.
CleanExiHS_TNS1.
ExpressionAtlasiQ9HBL0. baseline and differential.
GenevisibleiQ9HBL0. HS.

Organism-specific databases

HPAiCAB018774.
HPA036089.
HPA036090.

Interactioni

Subunit structurei

Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARP102753EBI-3389814,EBI-608057
KITP107212EBI-3389814,EBI-1379503
METP085812EBI-3389814,EBI-1039152

Protein-protein interaction databases

BioGridi112999. 7 interactions.
DIPiDIP-60948N.
IntActiQ9HBL0. 10 interactions.
STRINGi9606.ENSP00000171887.

Structurei

3D structure databases

ProteinModelPortaliQ9HBL0.
SMRiQ9HBL0. Positions 1458-1574, 1597-1729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 176173Phosphatase tensin-typePROSITE-ProRule annotationAdd
BLAST
Domaini181 – 307127C2 tensin-typePROSITE-ProRule annotationAdd
BLAST
Domaini1463 – 1572110SH2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi651 – 66717Gln-richAdd
BLAST
Compositional biasi1069 – 116092Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 C2 tensin-type domain.PROSITE-ProRule annotation
Contains 1 phosphatase tensin-type domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000119113.
HOGENOMiHOG000006936.
HOVERGENiHBG060186.
InParanoidiQ9HBL0.
KOiK18080.
OMAiMDHLENG.
OrthoDBiEOG091G0G8Y.
PhylomeDBiQ9HBL0.
TreeFamiTF315996.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HBL0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVSRTMEDS CELDLVYVTE RIIAVSFPST ANEENFRSNL REVAQMLKSK
60 70 80 90 100
HGGNYLLFNL SERRPDITKL HAKVLEFGWP DLHTPALEKI CSICKAMDTW
110 120 130 140 150
LNADPHNVVV LHNKGNRGRI GVVIAAYMHY SNISASADQA LDRFAMKRFY
160 170 180 190 200
EDKIVPIGQP SQRRYVHYFS GLLSGSIKMN NKPLFLHHVI MHGIPNFESK
210 220 230 240 250
GGCRPFLRIY QAMQPVYTSG IYNIPGDSQT SVCITIEPGL LLKGDILLKC
260 270 280 290 300
YHKKFRSPAR DVIFRVQFHT CAIHDLGVVF GKEDLDDAFK DDRFPEYGKV
310 320 330 340 350
EFVFSYGPEK IQGMEHLENG PSVSVDYNTS DPLIRWDSYD NFSGHRDDGM
360 370 380 390 400
EEVVGHTQGP LDGSLYAKVK KKDSLHGSTG AVNATRPTLS ATPNHVEHTL
410 420 430 440 450
SVSSDSGNST ASTKTDKTDE PVPGASSATA ALSPQEKREL DRLLSGFGLE
460 470 480 490 500
REKQGAMYHT QHLRSRPAGG SAVPSSGRHV VPAQVHVNGG ALASERETDI
510 520 530 540 550
LDDELPNQDG HSAGSMGTLS SLDGVTNTSE GGYPEALSPL TNGLDKSYPM
560 570 580 590 600
EPMVNGGGYP YESASRAGPA HAGHTAPMRP SYSAQEGLAG YQREGPHPAW
610 620 630 640 650
PQPVTTSHYA HDPSGMFRSQ SFSEAEPQLP PAPVRGGSSR EAVQRGLNSW
660 670 680 690 700
QQQQQQQQQP RPPPRQQERA HLESLVASRP SPQPLAETPI PSLPEFPRAA
710 720 730 740 750
SQQEIEQSIE TLNMLMLDLE PASAAAPLHK SQSVPGAWPG ASPLSSQPLS
760 770 780 790 800
GSSRQSHPLT QSRSGYIPSG HSLGTPEPAP RASLESVPPG RSYSPYDYQP
810 820 830 840 850
CLAGPNQDFH SKSPASSSLP AFLPTTHSPP GPQQPPASLP GLTAQPLLSP
860 870 880 890 900
KEATSDPSRT PEEEPLNLEG LVAHRVAGVQ AREKQPAEPP APLRRRAASD
910 920 930 940 950
GQYENQSPEA TSPRSPGVRS PVQCVSPELA LTIALNPGGR PKEPHLHSYK
960 970 980 990 1000
EAFEEMEGTS PSSPPPSGVR SPPGLAKTPL SALGLKPHNP ADILLHPTGV
1010 1020 1030 1040 1050
TRRRIQPEED EGKVVVRLSE EPRSYVESVA RTAVAGPRAQ DSEPKSFSAP
1060 1070 1080 1090 1100
ATQAYGHEIP LRNGTLGGSF VSPSPLSTSS PILSADSTSV GSFPSGESSD
1110 1120 1130 1140 1150
QGPRTPTQPL LESGFRSGSL GQPSPSAQRN YQSSSPLPTV GSSYSSPDYS
1160 1170 1180 1190 1200
LQHFSSSPES QARAQFSVAG VHTVPGSPQA RHRTVGTNTP PSPGFGWRAI
1210 1220 1230 1240 1250
NPSMAAPSSP SLSHHQMMGP PGTGFHGSTV SSPQSSAATT PGSPSLCRHP
1260 1270 1280 1290 1300
AGVYQVSGLH NKVATTPGSP SLGRHPGAHQ GNLASGLHSN AIASPGSPSL
1310 1320 1330 1340 1350
GRHLGGSGSV VPGSPCLDRH VAYGGYSTPE DRRPTLSRQS SASGYQAPST
1360 1370 1380 1390 1400
PSFPVSPAYY PGLSSPATSP SPDSAAFRQG SPTPALPEKR RMSVGDRAGS
1410 1420 1430 1440 1450
LPNYATINGK VSSPVASGMS SPSGGSTVSF SHTLPDFSKY SMPDNSPETR
1460 1470 1480 1490 1500
AKVKFVQDTS KYWYKPEISR EQAIALLKDQ EPGAFIIRDS HSFRGAYGLA
1510 1520 1530 1540 1550
MKVSSPPPTI MQQNKKGDMT HELVRHFLIE TGPRGVKLKG CPNEPNFGSL
1560 1570 1580 1590 1600
SALVYQHSII PLALPCKLVI PNRDPTDESK DSSGPANSTA DLLKQGAACN
1610 1620 1630 1640 1650
VLFVNSVDME SLTGPQAISK ATSETLAADP TPAATIVHFK VSAQGITLTD
1660 1670 1680 1690 1700
NQRKLFFRRH YPLNTVTFCD LDPQERKWMK TEGGAPAKLF GFVARKQGST
1710 1720 1730
TDNACHLFAE LDPNQPASAI VNFVSKVMLN AGQKR
Length:1,735
Mass (Da):185,701
Last modified:November 4, 2008 - v2
Checksum:i90C173D5E371EF3E
GO
Isoform 2 (identifier: Q9HBL0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVPFQQRKDCVLEGSTRVTPSVQPHLQPIRNM
     352-385: EVVGHTQGPLDGSLYAKVKKKDSLHGSTGAVNAT → DGNKQNTNSQSIGSISGGLEDQYTWPDTHWPSQS
     386-1735: Missing.

Note: No experimental confirmation available.
Show »
Length:416
Mass (Da):47,240
Checksum:i372FC64F2304C63E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791M → I in AAG33700 (PubMed:11023826).Curated
Sequence conflicti1412 – 14121S → A in AAG33700 (PubMed:11023826).Curated
Sequence conflicti1416 – 14161A → P in AAG33700 (PubMed:11023826).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti311 – 3111I → M.
Corresponds to variant rs11680854 [ dbSNP | Ensembl ].
VAR_047066
Natural varianti466 – 4661R → C.
Corresponds to variant rs3815849 [ dbSNP | Ensembl ].
VAR_047067
Natural varianti528 – 5281T → I.
Corresponds to variant rs3796033 [ dbSNP | Ensembl ].
VAR_047068
Natural varianti1004 – 10041R → W.
Corresponds to variant rs3796028 [ dbSNP | Ensembl ].
VAR_047069
Natural varianti1093 – 10931F → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_048004
Natural varianti1197 – 11971W → R.Combined sources1 Publication
Corresponds to variant rs2571445 [ dbSNP | Ensembl ].
VAR_047070
Natural varianti1604 – 16041V → I.1 Publication
Corresponds to variant rs918949 [ dbSNP | Ensembl ].
VAR_047071

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MVPFQQRKDCVLEGSTRVTP SVQPHLQPIRNM in isoform 2. 1 PublicationVSP_056335
Alternative sequencei352 – 38534EVVGH…AVNAT → DGNKQNTNSQSIGSISGGLE DQYTWPDTHWPSQS in isoform 2. 1 PublicationVSP_056336Add
BLAST
Alternative sequencei386 – 17351350Missing in isoform 2. 1 PublicationVSP_056337Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225896 mRNA. Translation: AAG33700.1.
AC009469 Genomic DNA. Translation: AAX88952.1.
AC010136 Genomic DNA. No translation available.
BC071905 mRNA. Translation: AAH71905.1.
CCDSiCCDS2407.1. [Q9HBL0-1]
RefSeqiNP_001294951.1. NM_001308022.1.
NP_072174.3. NM_022648.5. [Q9HBL0-1]
UniGeneiHs.471381.

Genome annotation databases

EnsembliENST00000171887; ENSP00000171887; ENSG00000079308. [Q9HBL0-1]
ENST00000310858; ENSP00000308321; ENSG00000079308. [Q9HBL0-2]
GeneIDi7145.
KEGGihsa:7145.
UCSCiuc002vgt.3. human. [Q9HBL0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225896 mRNA. Translation: AAG33700.1.
AC009469 Genomic DNA. Translation: AAX88952.1.
AC010136 Genomic DNA. No translation available.
BC071905 mRNA. Translation: AAH71905.1.
CCDSiCCDS2407.1. [Q9HBL0-1]
RefSeqiNP_001294951.1. NM_001308022.1.
NP_072174.3. NM_022648.5. [Q9HBL0-1]
UniGeneiHs.471381.

3D structure databases

ProteinModelPortaliQ9HBL0.
SMRiQ9HBL0. Positions 1458-1574, 1597-1729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112999. 7 interactions.
DIPiDIP-60948N.
IntActiQ9HBL0. 10 interactions.
STRINGi9606.ENSP00000171887.

PTM databases

DEPODiQ9HBL0.
iPTMnetiQ9HBL0.
PhosphoSiteiQ9HBL0.

Polymorphism and mutation databases

BioMutaiTNS1.
DMDMi212276466.

Proteomic databases

EPDiQ9HBL0.
MaxQBiQ9HBL0.
PaxDbiQ9HBL0.
PeptideAtlasiQ9HBL0.
PRIDEiQ9HBL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000171887; ENSP00000171887; ENSG00000079308. [Q9HBL0-1]
ENST00000310858; ENSP00000308321; ENSG00000079308. [Q9HBL0-2]
GeneIDi7145.
KEGGihsa:7145.
UCSCiuc002vgt.3. human. [Q9HBL0-1]

Organism-specific databases

CTDi7145.
GeneCardsiTNS1.
H-InvDBHIX0002818.
HGNCiHGNC:11973. TNS1.
HPAiCAB018774.
HPA036089.
HPA036090.
MIMi600076. gene.
neXtProtiNX_Q9HBL0.
PharmGKBiPA36660.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000119113.
HOGENOMiHOG000006936.
HOVERGENiHBG060186.
InParanoidiQ9HBL0.
KOiK18080.
OMAiMDHLENG.
OrthoDBiEOG091G0G8Y.
PhylomeDBiQ9HBL0.
TreeFamiTF315996.

Enzyme and pathway databases

SignaLinkiQ9HBL0.

Miscellaneous databases

ChiTaRSiTNS1. human.
GeneWikiiTNS1.
GenomeRNAii7145.
PMAP-CutDBQ9HBL0.
PROiQ9HBL0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079308.
CleanExiHS_TNS1.
ExpressionAtlasiQ9HBL0. baseline and differential.
GenevisibleiQ9HBL0. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTENS1_HUMAN
AccessioniPrimary (citable) accession number: Q9HBL0
Secondary accession number(s): Q4ZG71, Q6IPI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 4, 2008
Last modified: September 7, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.