ID   Q9HBK0_HUMAN            Unreviewed;       163 AA.
AC   Q9HBK0; B9ZVT9;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 117.
DE   RecName: Full=Natural resistance-associated macrophage protein 1 {ECO:0000256|ARBA:ARBA00015099};
DE   AltName: Full=Solute carrier family 11 member 1 {ECO:0000256|ARBA:ARBA00032337};
GN   Name=SLC11A1 {ECO:0000313|EMBL:AAG15403.1,
GN   ECO:0000313|Ensembl:ENSP00000346320.5};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAG15403.1};
RN   [1] {ECO:0000313|EMBL:AAG15403.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=10967134; DOI=10.1007/s003350010151;
RA   Marquet S., Lepage P., Hudson T.J., Musser J.M., Schurr E.;
RT   "Complete nucleotide sequence and genomic structure of the human NRAMP1
RT   gene region on chromosome region 2q35.";
RL   Mamm. Genome 11:755-762(2000).
RN   [2] {ECO:0000313|Ensembl:ENSP00000346320.5, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3] {ECO:0000313|EMBL:BAG57862.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAG57862.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSP00000346320.5}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in);
CC         Xref=Rhea:RHEA:29439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00035584};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(out) + Mn(2+)(in) = H(+)(in) + Mn(2+)(out);
CC         Xref=Rhea:RHEA:73063, ChEBI:CHEBI:15378, ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00035581};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out);
CC         Xref=Rhea:RHEA:28839, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00035594};
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Late endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004107}. Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the NRAMP family.
CC       {ECO:0000256|ARBA:ARBA00006670}.
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DR   EMBL; AC021016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF229163; AAG15403.1; -; Genomic_DNA.
DR   EMBL; AK294707; BAG57862.1; -; mRNA.
DR   ProteomicsDB; 81566; -.
DR   Ensembl; ENST00000354352.9; ENSP00000346320.5; ENSG00000018280.17.
DR   UCSC; uc061sko.1; human.
DR   HGNC; HGNC:10907; SLC11A1.
DR   VEuPathDB; HostDB:ENSG00000018280; -.
DR   GeneTree; ENSGT00940000160799; -.
DR   HOGENOM; CLU_1626488_0_0_1; -.
DR   ChiTaRS; SLC11A1; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000018280; Expressed in right lung and 136 other cell types or tissues.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046915; F:transition metal ion transmembrane transporter activity; IEA:UniProt.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   GO; GO:0006826; P:iron ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001046; NRAMP_fam.
DR   PANTHER; PTHR11706:SF52; NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1; 1.
DR   PANTHER; PTHR11706; SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER; 1.
DR   Pfam; PF01566; Nramp; 1.
PE   1: Evidence at protein level;
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022496};
KW   Iron {ECO:0000256|ARBA:ARBA00022496};
KW   Iron transport {ECO:0000256|ARBA:ARBA00022496};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Proteomics identification {ECO:0007829|MaxQB:Q9HBK0,
KW   ECO:0007829|PeptideAtlas:Q9HBK0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022496}.
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   163 AA;  17302 MW;  0C91BE16DA0AC9D4 CRC64;
     MTGDKGPQRL SGSSYGSISS PTSPTSPGPQ QAPPRETYLS EKIPIPDTKP GTFSLRKLWA
     FTGPGFLMSI AFLDPGNIES DLQAGAVAGF KLLWVLLWAT VLGLLCQRLA ARLGVVTGKD
     LGEVCHLYYP KSESRSVAQS GVQWCDVSSL QPLPPRCPAP SSG
//