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Protein

Collectrin

Gene

TMEM27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of SNARE complex function. Stimulator of beta cell replication.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147003-MONOMER.
ReactomeiR-HSA-264876. Insulin processing.

Protein family/group databases

MEROPSiM02.M01.
TCDBi2.A.22.6.3. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Collectrin
Alternative name(s):
Transmembrane protein 27
Gene namesi
Name:TMEM27
ORF Names:UNQ679/PRO1312
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:29437. TMEM27.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini15 – 141ExtracellularSequence analysisAdd BLAST127
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 222CytoplasmicSequence analysisAdd BLAST60

GO - Cellular componenti

  • brush border membrane Source: Ensembl
  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57393.
OpenTargetsiENSG00000147003.
PharmGKBiPA134994199.

Polymorphism and mutation databases

DMDMi74734254.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000024586715 – 222CollectrinAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Glycosylationi93N-linked (GlcNAc...)Sequence analysis1
Modified residuei214PhosphothreonineBy similarity1
Modified residuei220PhosphothreonineBy similarity1

Post-translational modificationi

Glycosylated.By similarity
The extracellular domain is cleaved and released from the cell membrane of pancreatic beta cells.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9HBJ8.
PaxDbiQ9HBJ8.
PeptideAtlasiQ9HBJ8.
PRIDEiQ9HBJ8.

PTM databases

iPTMnetiQ9HBJ8.
PhosphoSitePlusiQ9HBJ8.

Expressioni

Tissue specificityi

Kidney; collecting ducts. Pancreas; beta cells of islets.2 Publications

Gene expression databases

BgeeiENSG00000147003.
CleanExiHS_TMEM27.
GenevisibleiQ9HBJ8. HS.

Organism-specific databases

HPAiHPA048543.

Interactioni

Subunit structurei

Homodimer (By similarity). Associates with SLC6A18 (By similarity). Interacts with SNAPIN.By similarity1 Publication

Protein-protein interaction databases

BioGridi121500. 1 interactor.
IntActiQ9HBJ8. 1 interactor.
STRINGi9606.ENSP00000369699.

Structurei

3D structure databases

ProteinModelPortaliQ9HBJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM27 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHHW. Eukaryota.
ENOG4111IUN. LUCA.
GeneTreeiENSGT00520000055576.
HOGENOMiHOG000231488.
HOVERGENiHBG061096.
InParanoidiQ9HBJ8.
KOiK20004.
OMAiEDKCENT.
OrthoDBiEOG091G0LFC.
PhylomeDBiQ9HBJ8.
TreeFamiTF335519.

Family and domain databases

InterProiIPR031588. Collectrin_dom.
IPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF16959. Collectrin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HBJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWLLFFLVT AIHAELCQPG AENAFKVRLS IRTALGDKAY AWDTNEEYLF
60 70 80 90 100
KAMVAFSMRK VPNREATEIS HVLLCNVTQR VSFWFVVTDP SKNHTLPAVE
110 120 130 140 150
VQSAIRMNKN RINNAFFLND QTLEFLKIPS TLAPPMDPSV PIWIIIFGVI
160 170 180 190 200
FCIIIVAIAL LILSGIWQRR RKNKEPSEVD DAEDKCENMI TIENGIPSDP
210 220
LDMKGGHIND AFMTEDERLT PL
Length:222
Mass (Da):25,235
Last modified:March 1, 2001 - v1
Checksum:i52C0ED522134ED05
GO

Sequence cautioni

The sequence AAQ89419 differs from that shown. Reason: Frameshift at position 207.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229179 mRNA. Translation: AAG09466.1.
AY359060 mRNA. Translation: AAQ89419.1. Frameshift.
AK313835 mRNA. Translation: BAG36568.1.
CH471074 Genomic DNA. Translation: EAW98894.1.
BC014317 mRNA. Translation: AAH14317.1.
BC015099 mRNA. Translation: AAH15099.1.
BC050606 mRNA. Translation: AAH50606.1.
CCDSiCCDS14170.1.
RefSeqiNP_065716.1. NM_020665.5.
UniGeneiHs.129614.

Genome annotation databases

EnsembliENST00000380342; ENSP00000369699; ENSG00000147003.
GeneIDi57393.
KEGGihsa:57393.
UCSCiuc004cxc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229179 mRNA. Translation: AAG09466.1.
AY359060 mRNA. Translation: AAQ89419.1. Frameshift.
AK313835 mRNA. Translation: BAG36568.1.
CH471074 Genomic DNA. Translation: EAW98894.1.
BC014317 mRNA. Translation: AAH14317.1.
BC015099 mRNA. Translation: AAH15099.1.
BC050606 mRNA. Translation: AAH50606.1.
CCDSiCCDS14170.1.
RefSeqiNP_065716.1. NM_020665.5.
UniGeneiHs.129614.

3D structure databases

ProteinModelPortaliQ9HBJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121500. 1 interactor.
IntActiQ9HBJ8. 1 interactor.
STRINGi9606.ENSP00000369699.

Protein family/group databases

MEROPSiM02.M01.
TCDBi2.A.22.6.3. the neurotransmitter:sodium symporter (nss) family.

PTM databases

iPTMnetiQ9HBJ8.
PhosphoSitePlusiQ9HBJ8.

Polymorphism and mutation databases

DMDMi74734254.

Proteomic databases

EPDiQ9HBJ8.
PaxDbiQ9HBJ8.
PeptideAtlasiQ9HBJ8.
PRIDEiQ9HBJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380342; ENSP00000369699; ENSG00000147003.
GeneIDi57393.
KEGGihsa:57393.
UCSCiuc004cxc.4. human.

Organism-specific databases

CTDi57393.
DisGeNETi57393.
GeneCardsiTMEM27.
HGNCiHGNC:29437. TMEM27.
HPAiHPA048543.
MIMi300631. gene.
neXtProtiNX_Q9HBJ8.
OpenTargetsiENSG00000147003.
PharmGKBiPA134994199.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHHW. Eukaryota.
ENOG4111IUN. LUCA.
GeneTreeiENSGT00520000055576.
HOGENOMiHOG000231488.
HOVERGENiHBG061096.
InParanoidiQ9HBJ8.
KOiK20004.
OMAiEDKCENT.
OrthoDBiEOG091G0LFC.
PhylomeDBiQ9HBJ8.
TreeFamiTF335519.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147003-MONOMER.
ReactomeiR-HSA-264876. Insulin processing.

Miscellaneous databases

GenomeRNAii57393.
PROiQ9HBJ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147003.
CleanExiHS_TMEM27.
GenevisibleiQ9HBJ8. HS.

Family and domain databases

InterProiIPR031588. Collectrin_dom.
IPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF16959. Collectrin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM27_HUMAN
AccessioniPrimary (citable) accession number: Q9HBJ8
Secondary accession number(s): B2R9M1, Q6UW07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.