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Protein

Collectrin

Gene

TMEM27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of SNARE complex function. Stimulator of beta cell replication.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-264876 Insulin processing

Protein family/group databases

MEROPSiM02.M01
TCDBi2.A.22.6.3 the neurotransmitter:sodium symporter (nss) family

Names & Taxonomyi

Protein namesi
Recommended name:
Collectrin
Alternative name(s):
Transmembrane protein 27
Gene namesi
Name:TMEM27
ORF Names:UNQ679/PRO1312
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147003.5
HGNCiHGNC:29437 TMEM27
MIMi300631 gene
neXtProtiNX_Q9HBJ8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini15 – 141ExtracellularSequence analysisAdd BLAST127
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 222CytoplasmicSequence analysisAdd BLAST60

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57393
OpenTargetsiENSG00000147003
PharmGKBiPA134994199

Polymorphism and mutation databases

DMDMi74734254

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000024586715 – 222CollectrinAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei214PhosphothreonineBy similarity1
Modified residuei220PhosphothreonineBy similarity1

Post-translational modificationi

Glycosylated.By similarity
The extracellular domain is cleaved and released from the cell membrane of pancreatic beta cells.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9HBJ8
PeptideAtlasiQ9HBJ8
PRIDEiQ9HBJ8

PTM databases

iPTMnetiQ9HBJ8
PhosphoSitePlusiQ9HBJ8

Expressioni

Tissue specificityi

Kidney; collecting ducts. Pancreas; beta cells of islets.2 Publications

Gene expression databases

BgeeiENSG00000147003
CleanExiHS_TMEM27
GenevisibleiQ9HBJ8 HS

Organism-specific databases

HPAiHPA048543

Interactioni

Subunit structurei

Homodimer (By similarity). Associates with SLC6A18 (By similarity). Interacts with SNAPIN.By similarity1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi1215001 interactor.
IntActiQ9HBJ8 1 interactor.
STRINGi9606.ENSP00000369699

Structurei

3D structure databases

ProteinModelPortaliQ9HBJ8
SMRiQ9HBJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM27 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHHW Eukaryota
ENOG4111IUN LUCA
GeneTreeiENSGT00520000055576
HOGENOMiHOG000231488
HOVERGENiHBG061096
InParanoidiQ9HBJ8
KOiK20004
OMAiEDKCENT
OrthoDBiEOG091G0LFC
PhylomeDBiQ9HBJ8
TreeFamiTF335519

Family and domain databases

InterProiView protein in InterPro
IPR031588 Collectrin_dom
IPR001548 Peptidase_M2
PANTHERiPTHR10514 PTHR10514, 1 hit
PfamiView protein in Pfam
PF16959 Collectrin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HBJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWLLFFLVT AIHAELCQPG AENAFKVRLS IRTALGDKAY AWDTNEEYLF
60 70 80 90 100
KAMVAFSMRK VPNREATEIS HVLLCNVTQR VSFWFVVTDP SKNHTLPAVE
110 120 130 140 150
VQSAIRMNKN RINNAFFLND QTLEFLKIPS TLAPPMDPSV PIWIIIFGVI
160 170 180 190 200
FCIIIVAIAL LILSGIWQRR RKNKEPSEVD DAEDKCENMI TIENGIPSDP
210 220
LDMKGGHIND AFMTEDERLT PL
Length:222
Mass (Da):25,235
Last modified:March 1, 2001 - v1
Checksum:i52C0ED522134ED05
GO

Sequence cautioni

The sequence AAQ89419 differs from that shown. Reason: Frameshift at position 207.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229179 mRNA Translation: AAG09466.1
AY359060 mRNA Translation: AAQ89419.1 Frameshift.
AK313835 mRNA Translation: BAG36568.1
CH471074 Genomic DNA Translation: EAW98894.1
BC014317 mRNA Translation: AAH14317.1
BC015099 mRNA Translation: AAH15099.1
BC050606 mRNA Translation: AAH50606.1
CCDSiCCDS14170.1
RefSeqiNP_065716.1, NM_020665.5
UniGeneiHs.129614

Genome annotation databases

EnsembliENST00000380342; ENSP00000369699; ENSG00000147003
GeneIDi57393
KEGGihsa:57393
UCSCiuc004cxc.4 human

Similar proteinsi

Entry informationi

Entry nameiTMM27_HUMAN
AccessioniPrimary (citable) accession number: Q9HBJ8
Secondary accession number(s): B2R9M1, Q6UW07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome