Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9HBJ7 (UBP29_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 29

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 29
Ubiquitin thioesterase 29
Ubiquitin-specific-processing protease 29
Gene names
Name:USP29
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length922 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Coding sequence diversityPolymorphism
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

ubiquitin thiolesterase activity

Traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 922922Ubiquitin carboxyl-terminal hydrolase 29
PRO_0000080660

Regions

Domain285 – 885601USP

Sites

Active site2941Nucleophile By similarity
Active site8401Proton acceptor By similarity

Natural variations

Natural variant3681N → S.
Corresponds to variant rs1027392 [ dbSNP | Ensembl ].
VAR_024590
Natural variant5861E → K.
Corresponds to variant rs3795003 [ dbSNP | Ensembl ].
VAR_022055

Sequences

Sequence LengthMass (Da)Tools
Q9HBJ7 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 122B56AE6FFFF364

FASTA922104,156
        10         20         30         40         50         60 
MISLKVCGFI QIWSQKTGMT KLKEALIETV QRQKEIKLVV TFKSGKFIRI FQLSNNIRSV 

        70         80         90        100        110        120 
VLRHCKKRQS HLRLTLKNNV FLFIDKLSYR DAKQLNMFLD IIHQNKSQQP MKSDDDWSVF 

       130        140        150        160        170        180 
ESRNMLKEID KTSFYSICNK PSYQKMPLFM SKSPTHVKKG ILENQGGKGQ NTLSSDVQTN 

       190        200        210        220        230        240 
EDILKEDNPV PNKKYKTDSL KYIQSNRKNP SSLEDLEKDR DLKLGPSFNT NCNGNPNLDE 

       250        260        270        280        290        300 
TVLATQTLNA KNGLTSPLEP EHSQGDPRCN KAQVPLDSHS QQLQQGFPNL GNTCYMNAVL 

       310        320        330        340        350        360 
QSLFAIPSFA DDLLTQGVPW EYIPFEALIM TLTQLLALKD FCSTKIKREL LGNVKKVISA 

       370        380        390        400        410        420 
VAEIFSGNMQ NDAHEFLGQC LDQLKEDMEK LNATLNTGKE CGDENSSPQM HVGSAATKVF 

       430        440        450        460        470        480 
VCPVVANFEF ELQLSLICKA CGHAVLKVEP NNYLSINLHQ ETKPLPLSIQ NSLDLFFKEE 

       490        500        510        520        530        540 
ELEYNCQMCK QKSCVARHTF SRLSRVLIIH LKRYSFNNAW LLVKNNEQVY IPKSLSLSSY 

       550        560        570        580        590        600 
CNESTKPPLP LSSSAPVGKC EVLEVSQEMI SEINSPLTPS MKLTSESSDS LVLPVEPDKN 

       610        620        630        640        650        660 
ADLQRFQRDC GDASQEQHQR DLENGSALES ELVHFRDRAI GEKELPVADS LMDQGDISLP 

       670        680        690        700        710        720 
VMYEDGGKLI SSPDTRLVEV HLQEVPQHPE LQKYEKTNTF VEFNFDSVTE STNGFYDCKE 

       730        740        750        760        770        780 
NRIPEGSQGM AEQLQQCIEE SIIDEFLQQA PPPGVRKLDA QEHTEETLNQ STELRLQKAD 

       790        800        810        820        830        840 
LNHLGALGSD NPGNKNILDA ENTRGEAKEL TRNVKMGDPL QAYRLISVVS HIGSSPNSGH 

       850        860        870        880        890        900 
YISDVYDFQK QAWFTYNDLC VSEISETKMQ EARLHSGYIF FYMHNGIFEE LLRKAENSRL 

       910        920 
PSTQAGVIPQ GEYEGDSLYR PA 

« Hide

References

[1]"Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4."
Kim J., Noskov V.N., Lu X., Bergmann A., Ren X., Warth T., Richardson P., Kouprina N., Stubbs L.
Genome Res. 10:1138-1147(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF229438 mRNA. Translation: AAG10401.1.
RefSeqNP_065954.1. NM_020903.2.
UniGeneHs.515632.

3D structure databases

ProteinModelPortalQ9HBJ7.
SMRQ9HBJ7. Positions 3-106, 266-548.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121696. 2 interactions.
IntActQ9HBJ7. 2 interactions.
MINTMINT-8145677.
STRING9606.ENSP00000254181.

Protein family/group databases

MEROPSC19.040.

PTM databases

PhosphoSiteQ9HBJ7.

Polymorphism databases

DMDM23396891.

Proteomic databases

PaxDbQ9HBJ7.
PRIDEQ9HBJ7.

Protocols and materials databases

DNASU57663.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254181; ENSP00000254181; ENSG00000131864.
ENST00000598197; ENSP00000470747; ENSG00000131864.
GeneID57663.
KEGGhsa:57663.
UCSCuc002qny.3. human.

Organism-specific databases

CTD57663.
GeneCardsGC19P057631.
HGNCHGNC:18563. USP29.
HPAHPA021064.
MIM609546. gene.
neXtProtNX_Q9HBJ7.
PharmGKBPA38349.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5560.
HOGENOMHOG000060197.
HOVERGENHBG055893.
InParanoidQ9HBJ7.
KOK11850.
OMAGFIQIWS.
OrthoDBEOG7HMS09.
PhylomeDBQ9HBJ7.
TreeFamTF323032.

Gene expression databases

ArrayExpressQ9HBJ7.
BgeeQ9HBJ7.
CleanExHS_USP29.
GenevestigatorQ9HBJ7.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi57663.
NextBio64438.
PROQ9HBJ7.
SOURCESearch...

Entry information

Entry nameUBP29_HUMAN
AccessionPrimary (citable) accession number: Q9HBJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: March 19, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM