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Q9HBJ7

- UBP29_HUMAN

UniProt

Q9HBJ7 - UBP29_HUMAN

Protein

Ubiquitin carboxyl-terminal hydrolase 29

Gene

USP29

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei294 – 2941NucleophilePROSITE-ProRule annotation
    Active sitei840 – 8401Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.040.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 29 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 29
    Ubiquitin thioesterase 29
    Ubiquitin-specific-processing protease 29
    Gene namesi
    Name:USP29
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:18563. USP29.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38349.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 922922Ubiquitin carboxyl-terminal hydrolase 29PRO_0000080660Add
    BLAST

    Proteomic databases

    PaxDbiQ9HBJ7.
    PRIDEiQ9HBJ7.

    PTM databases

    PhosphoSiteiQ9HBJ7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9HBJ7.
    BgeeiQ9HBJ7.
    CleanExiHS_USP29.
    GenevestigatoriQ9HBJ7.

    Organism-specific databases

    HPAiHPA021064.

    Interactioni

    Protein-protein interaction databases

    BioGridi121696. 3 interactions.
    IntActiQ9HBJ7. 2 interactions.
    MINTiMINT-8145677.
    STRINGi9606.ENSP00000254181.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HBJ7.
    SMRiQ9HBJ7. Positions 3-106, 286-544.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini285 – 885601USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5560.
    HOGENOMiHOG000060197.
    HOVERGENiHBG055893.
    InParanoidiQ9HBJ7.
    KOiK11850.
    OMAiGFIQIWS.
    OrthoDBiEOG7HMS09.
    PhylomeDBiQ9HBJ7.
    TreeFamiTF323032.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HBJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISLKVCGFI QIWSQKTGMT KLKEALIETV QRQKEIKLVV TFKSGKFIRI    50
    FQLSNNIRSV VLRHCKKRQS HLRLTLKNNV FLFIDKLSYR DAKQLNMFLD 100
    IIHQNKSQQP MKSDDDWSVF ESRNMLKEID KTSFYSICNK PSYQKMPLFM 150
    SKSPTHVKKG ILENQGGKGQ NTLSSDVQTN EDILKEDNPV PNKKYKTDSL 200
    KYIQSNRKNP SSLEDLEKDR DLKLGPSFNT NCNGNPNLDE TVLATQTLNA 250
    KNGLTSPLEP EHSQGDPRCN KAQVPLDSHS QQLQQGFPNL GNTCYMNAVL 300
    QSLFAIPSFA DDLLTQGVPW EYIPFEALIM TLTQLLALKD FCSTKIKREL 350
    LGNVKKVISA VAEIFSGNMQ NDAHEFLGQC LDQLKEDMEK LNATLNTGKE 400
    CGDENSSPQM HVGSAATKVF VCPVVANFEF ELQLSLICKA CGHAVLKVEP 450
    NNYLSINLHQ ETKPLPLSIQ NSLDLFFKEE ELEYNCQMCK QKSCVARHTF 500
    SRLSRVLIIH LKRYSFNNAW LLVKNNEQVY IPKSLSLSSY CNESTKPPLP 550
    LSSSAPVGKC EVLEVSQEMI SEINSPLTPS MKLTSESSDS LVLPVEPDKN 600
    ADLQRFQRDC GDASQEQHQR DLENGSALES ELVHFRDRAI GEKELPVADS 650
    LMDQGDISLP VMYEDGGKLI SSPDTRLVEV HLQEVPQHPE LQKYEKTNTF 700
    VEFNFDSVTE STNGFYDCKE NRIPEGSQGM AEQLQQCIEE SIIDEFLQQA 750
    PPPGVRKLDA QEHTEETLNQ STELRLQKAD LNHLGALGSD NPGNKNILDA 800
    ENTRGEAKEL TRNVKMGDPL QAYRLISVVS HIGSSPNSGH YISDVYDFQK 850
    QAWFTYNDLC VSEISETKMQ EARLHSGYIF FYMHNGIFEE LLRKAENSRL 900
    PSTQAGVIPQ GEYEGDSLYR PA 922
    Length:922
    Mass (Da):104,156
    Last modified:March 1, 2001 - v1
    Checksum:i122B56AE6FFFF364
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti368 – 3681N → S.
    Corresponds to variant rs1027392 [ dbSNP | Ensembl ].
    VAR_024590
    Natural varianti586 – 5861E → K.
    Corresponds to variant rs3795003 [ dbSNP | Ensembl ].
    VAR_022055

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229438 mRNA. Translation: AAG10401.1.
    CCDSiCCDS33124.1.
    RefSeqiNP_065954.1. NM_020903.2.
    UniGeneiHs.515632.

    Genome annotation databases

    EnsembliENST00000254181; ENSP00000254181; ENSG00000131864.
    ENST00000598197; ENSP00000470747; ENSG00000131864.
    GeneIDi57663.
    KEGGihsa:57663.
    UCSCiuc002qny.3. human.

    Polymorphism databases

    DMDMi23396891.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229438 mRNA. Translation: AAG10401.1 .
    CCDSi CCDS33124.1.
    RefSeqi NP_065954.1. NM_020903.2.
    UniGenei Hs.515632.

    3D structure databases

    ProteinModelPortali Q9HBJ7.
    SMRi Q9HBJ7. Positions 3-106, 286-544.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121696. 3 interactions.
    IntActi Q9HBJ7. 2 interactions.
    MINTi MINT-8145677.
    STRINGi 9606.ENSP00000254181.

    Protein family/group databases

    MEROPSi C19.040.

    PTM databases

    PhosphoSitei Q9HBJ7.

    Polymorphism databases

    DMDMi 23396891.

    Proteomic databases

    PaxDbi Q9HBJ7.
    PRIDEi Q9HBJ7.

    Protocols and materials databases

    DNASUi 57663.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254181 ; ENSP00000254181 ; ENSG00000131864 .
    ENST00000598197 ; ENSP00000470747 ; ENSG00000131864 .
    GeneIDi 57663.
    KEGGi hsa:57663.
    UCSCi uc002qny.3. human.

    Organism-specific databases

    CTDi 57663.
    GeneCardsi GC19P057631.
    HGNCi HGNC:18563. USP29.
    HPAi HPA021064.
    MIMi 609546. gene.
    neXtProti NX_Q9HBJ7.
    PharmGKBi PA38349.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5560.
    HOGENOMi HOG000060197.
    HOVERGENi HBG055893.
    InParanoidi Q9HBJ7.
    KOi K11850.
    OMAi GFIQIWS.
    OrthoDBi EOG7HMS09.
    PhylomeDBi Q9HBJ7.
    TreeFami TF323032.

    Miscellaneous databases

    GenomeRNAii 57663.
    NextBioi 64438.
    PROi Q9HBJ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HBJ7.
    Bgeei Q9HBJ7.
    CleanExi HS_USP29.
    Genevestigatori Q9HBJ7.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4."
      Kim J., Noskov V.N., Lu X., Bergmann A., Ren X., Warth T., Richardson P., Kouprina N., Stubbs L.
      Genome Res. 10:1138-1147(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiUBP29_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3