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Protein

Ubiquitin carboxyl-terminal hydrolase 29

Gene

USP29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei294 – 2941NucleophilePROSITE-ProRule annotation
Active sitei840 – 8401Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.040.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 29 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 29
Ubiquitin thioesterase 29
Ubiquitin-specific-processing protease 29
Gene namesi
Name:USP29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18563. USP29.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38349.

Polymorphism and mutation databases

BioMutaiUSP29.
DMDMi23396891.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 922922Ubiquitin carboxyl-terminal hydrolase 29PRO_0000080660Add
BLAST

Proteomic databases

PaxDbiQ9HBJ7.
PRIDEiQ9HBJ7.

PTM databases

PhosphoSiteiQ9HBJ7.

Expressioni

Gene expression databases

BgeeiQ9HBJ7.
CleanExiHS_USP29.
ExpressionAtlasiQ9HBJ7. baseline and differential.
GenevisibleiQ9HBJ7. HS.

Organism-specific databases

HPAiHPA021064.

Interactioni

Protein-protein interaction databases

BioGridi121696. 3 interactions.
IntActiQ9HBJ7. 2 interactions.
MINTiMINT-8145677.
STRINGi9606.ENSP00000254181.

Structurei

3D structure databases

ProteinModelPortaliQ9HBJ7.
SMRiQ9HBJ7. Positions 3-106, 286-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 885601USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00440000033542.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiQ9HBJ7.
KOiK11850.
OMAiVFVCPVV.
OrthoDBiEOG7HMS09.
PhylomeDBiQ9HBJ7.
TreeFamiTF323032.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HBJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISLKVCGFI QIWSQKTGMT KLKEALIETV QRQKEIKLVV TFKSGKFIRI
60 70 80 90 100
FQLSNNIRSV VLRHCKKRQS HLRLTLKNNV FLFIDKLSYR DAKQLNMFLD
110 120 130 140 150
IIHQNKSQQP MKSDDDWSVF ESRNMLKEID KTSFYSICNK PSYQKMPLFM
160 170 180 190 200
SKSPTHVKKG ILENQGGKGQ NTLSSDVQTN EDILKEDNPV PNKKYKTDSL
210 220 230 240 250
KYIQSNRKNP SSLEDLEKDR DLKLGPSFNT NCNGNPNLDE TVLATQTLNA
260 270 280 290 300
KNGLTSPLEP EHSQGDPRCN KAQVPLDSHS QQLQQGFPNL GNTCYMNAVL
310 320 330 340 350
QSLFAIPSFA DDLLTQGVPW EYIPFEALIM TLTQLLALKD FCSTKIKREL
360 370 380 390 400
LGNVKKVISA VAEIFSGNMQ NDAHEFLGQC LDQLKEDMEK LNATLNTGKE
410 420 430 440 450
CGDENSSPQM HVGSAATKVF VCPVVANFEF ELQLSLICKA CGHAVLKVEP
460 470 480 490 500
NNYLSINLHQ ETKPLPLSIQ NSLDLFFKEE ELEYNCQMCK QKSCVARHTF
510 520 530 540 550
SRLSRVLIIH LKRYSFNNAW LLVKNNEQVY IPKSLSLSSY CNESTKPPLP
560 570 580 590 600
LSSSAPVGKC EVLEVSQEMI SEINSPLTPS MKLTSESSDS LVLPVEPDKN
610 620 630 640 650
ADLQRFQRDC GDASQEQHQR DLENGSALES ELVHFRDRAI GEKELPVADS
660 670 680 690 700
LMDQGDISLP VMYEDGGKLI SSPDTRLVEV HLQEVPQHPE LQKYEKTNTF
710 720 730 740 750
VEFNFDSVTE STNGFYDCKE NRIPEGSQGM AEQLQQCIEE SIIDEFLQQA
760 770 780 790 800
PPPGVRKLDA QEHTEETLNQ STELRLQKAD LNHLGALGSD NPGNKNILDA
810 820 830 840 850
ENTRGEAKEL TRNVKMGDPL QAYRLISVVS HIGSSPNSGH YISDVYDFQK
860 870 880 890 900
QAWFTYNDLC VSEISETKMQ EARLHSGYIF FYMHNGIFEE LLRKAENSRL
910 920
PSTQAGVIPQ GEYEGDSLYR PA
Length:922
Mass (Da):104,156
Last modified:March 1, 2001 - v1
Checksum:i122B56AE6FFFF364
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti368 – 3681N → S.
Corresponds to variant rs1027392 [ dbSNP | Ensembl ].
VAR_024590
Natural varianti586 – 5861E → K.
Corresponds to variant rs3795003 [ dbSNP | Ensembl ].
VAR_022055

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229438 mRNA. Translation: AAG10401.1.
CCDSiCCDS33124.1.
RefSeqiNP_065954.1. NM_020903.2.
UniGeneiHs.515632.

Genome annotation databases

EnsembliENST00000254181; ENSP00000254181; ENSG00000131864.
ENST00000598197; ENSP00000470747; ENSG00000131864.
GeneIDi57663.
KEGGihsa:57663.
UCSCiuc002qny.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229438 mRNA. Translation: AAG10401.1.
CCDSiCCDS33124.1.
RefSeqiNP_065954.1. NM_020903.2.
UniGeneiHs.515632.

3D structure databases

ProteinModelPortaliQ9HBJ7.
SMRiQ9HBJ7. Positions 3-106, 286-544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121696. 3 interactions.
IntActiQ9HBJ7. 2 interactions.
MINTiMINT-8145677.
STRINGi9606.ENSP00000254181.

Protein family/group databases

MEROPSiC19.040.

PTM databases

PhosphoSiteiQ9HBJ7.

Polymorphism and mutation databases

BioMutaiUSP29.
DMDMi23396891.

Proteomic databases

PaxDbiQ9HBJ7.
PRIDEiQ9HBJ7.

Protocols and materials databases

DNASUi57663.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254181; ENSP00000254181; ENSG00000131864.
ENST00000598197; ENSP00000470747; ENSG00000131864.
GeneIDi57663.
KEGGihsa:57663.
UCSCiuc002qny.3. human.

Organism-specific databases

CTDi57663.
GeneCardsiGC19P057631.
HGNCiHGNC:18563. USP29.
HPAiHPA021064.
MIMi609546. gene.
neXtProtiNX_Q9HBJ7.
PharmGKBiPA38349.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00440000033542.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiQ9HBJ7.
KOiK11850.
OMAiVFVCPVV.
OrthoDBiEOG7HMS09.
PhylomeDBiQ9HBJ7.
TreeFamiTF323032.

Miscellaneous databases

GenomeRNAii57663.
NextBioi64438.
PROiQ9HBJ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HBJ7.
CleanExiHS_USP29.
ExpressionAtlasiQ9HBJ7. baseline and differential.
GenevisibleiQ9HBJ7. HS.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4."
    Kim J., Noskov V.N., Lu X., Bergmann A., Ren X., Warth T., Richardson P., Kouprina N., Stubbs L.
    Genome Res. 10:1138-1147(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiUBP29_HUMAN
AccessioniPrimary (citable) accession number: Q9HBJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.