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Q9HBJ7

- UBP29_HUMAN

UniProt

Q9HBJ7 - UBP29_HUMAN

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Protein

Ubiquitin carboxyl-terminal hydrolase 29

Gene

USP29

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei294 – 2941NucleophilePROSITE-ProRule annotation
Active sitei840 – 8401Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.040.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 29 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 29
Ubiquitin thioesterase 29
Ubiquitin-specific-processing protease 29
Gene namesi
Name:USP29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:18563. USP29.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38349.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 922922Ubiquitin carboxyl-terminal hydrolase 29PRO_0000080660Add
BLAST

Proteomic databases

PaxDbiQ9HBJ7.
PRIDEiQ9HBJ7.

PTM databases

PhosphoSiteiQ9HBJ7.

Expressioni

Gene expression databases

BgeeiQ9HBJ7.
CleanExiHS_USP29.
ExpressionAtlasiQ9HBJ7. baseline.
GenevestigatoriQ9HBJ7.

Organism-specific databases

HPAiHPA021064.

Interactioni

Protein-protein interaction databases

BioGridi121696. 3 interactions.
IntActiQ9HBJ7. 2 interactions.
MINTiMINT-8145677.
STRINGi9606.ENSP00000254181.

Structurei

3D structure databases

ProteinModelPortaliQ9HBJ7.
SMRiQ9HBJ7. Positions 3-106, 286-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 885601USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00440000033542.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiQ9HBJ7.
KOiK11850.
OMAiGFIQIWS.
OrthoDBiEOG7HMS09.
PhylomeDBiQ9HBJ7.
TreeFamiTF323032.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HBJ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISLKVCGFI QIWSQKTGMT KLKEALIETV QRQKEIKLVV TFKSGKFIRI
60 70 80 90 100
FQLSNNIRSV VLRHCKKRQS HLRLTLKNNV FLFIDKLSYR DAKQLNMFLD
110 120 130 140 150
IIHQNKSQQP MKSDDDWSVF ESRNMLKEID KTSFYSICNK PSYQKMPLFM
160 170 180 190 200
SKSPTHVKKG ILENQGGKGQ NTLSSDVQTN EDILKEDNPV PNKKYKTDSL
210 220 230 240 250
KYIQSNRKNP SSLEDLEKDR DLKLGPSFNT NCNGNPNLDE TVLATQTLNA
260 270 280 290 300
KNGLTSPLEP EHSQGDPRCN KAQVPLDSHS QQLQQGFPNL GNTCYMNAVL
310 320 330 340 350
QSLFAIPSFA DDLLTQGVPW EYIPFEALIM TLTQLLALKD FCSTKIKREL
360 370 380 390 400
LGNVKKVISA VAEIFSGNMQ NDAHEFLGQC LDQLKEDMEK LNATLNTGKE
410 420 430 440 450
CGDENSSPQM HVGSAATKVF VCPVVANFEF ELQLSLICKA CGHAVLKVEP
460 470 480 490 500
NNYLSINLHQ ETKPLPLSIQ NSLDLFFKEE ELEYNCQMCK QKSCVARHTF
510 520 530 540 550
SRLSRVLIIH LKRYSFNNAW LLVKNNEQVY IPKSLSLSSY CNESTKPPLP
560 570 580 590 600
LSSSAPVGKC EVLEVSQEMI SEINSPLTPS MKLTSESSDS LVLPVEPDKN
610 620 630 640 650
ADLQRFQRDC GDASQEQHQR DLENGSALES ELVHFRDRAI GEKELPVADS
660 670 680 690 700
LMDQGDISLP VMYEDGGKLI SSPDTRLVEV HLQEVPQHPE LQKYEKTNTF
710 720 730 740 750
VEFNFDSVTE STNGFYDCKE NRIPEGSQGM AEQLQQCIEE SIIDEFLQQA
760 770 780 790 800
PPPGVRKLDA QEHTEETLNQ STELRLQKAD LNHLGALGSD NPGNKNILDA
810 820 830 840 850
ENTRGEAKEL TRNVKMGDPL QAYRLISVVS HIGSSPNSGH YISDVYDFQK
860 870 880 890 900
QAWFTYNDLC VSEISETKMQ EARLHSGYIF FYMHNGIFEE LLRKAENSRL
910 920
PSTQAGVIPQ GEYEGDSLYR PA
Length:922
Mass (Da):104,156
Last modified:March 1, 2001 - v1
Checksum:i122B56AE6FFFF364
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti368 – 3681N → S.
Corresponds to variant rs1027392 [ dbSNP | Ensembl ].
VAR_024590
Natural varianti586 – 5861E → K.
Corresponds to variant rs3795003 [ dbSNP | Ensembl ].
VAR_022055

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF229438 mRNA. Translation: AAG10401.1.
CCDSiCCDS33124.1.
RefSeqiNP_065954.1. NM_020903.2.
UniGeneiHs.515632.

Genome annotation databases

EnsembliENST00000254181; ENSP00000254181; ENSG00000131864.
ENST00000598197; ENSP00000470747; ENSG00000131864.
GeneIDi57663.
KEGGihsa:57663.
UCSCiuc002qny.3. human.

Polymorphism databases

DMDMi23396891.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF229438 mRNA. Translation: AAG10401.1 .
CCDSi CCDS33124.1.
RefSeqi NP_065954.1. NM_020903.2.
UniGenei Hs.515632.

3D structure databases

ProteinModelPortali Q9HBJ7.
SMRi Q9HBJ7. Positions 3-106, 286-544.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121696. 3 interactions.
IntActi Q9HBJ7. 2 interactions.
MINTi MINT-8145677.
STRINGi 9606.ENSP00000254181.

Protein family/group databases

MEROPSi C19.040.

PTM databases

PhosphoSitei Q9HBJ7.

Polymorphism databases

DMDMi 23396891.

Proteomic databases

PaxDbi Q9HBJ7.
PRIDEi Q9HBJ7.

Protocols and materials databases

DNASUi 57663.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254181 ; ENSP00000254181 ; ENSG00000131864 .
ENST00000598197 ; ENSP00000470747 ; ENSG00000131864 .
GeneIDi 57663.
KEGGi hsa:57663.
UCSCi uc002qny.3. human.

Organism-specific databases

CTDi 57663.
GeneCardsi GC19P057631.
HGNCi HGNC:18563. USP29.
HPAi HPA021064.
MIMi 609546. gene.
neXtProti NX_Q9HBJ7.
PharmGKBi PA38349.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5560.
GeneTreei ENSGT00440000033542.
HOGENOMi HOG000060197.
HOVERGENi HBG055893.
InParanoidi Q9HBJ7.
KOi K11850.
OMAi GFIQIWS.
OrthoDBi EOG7HMS09.
PhylomeDBi Q9HBJ7.
TreeFami TF323032.

Miscellaneous databases

GenomeRNAii 57663.
NextBioi 64438.
PROi Q9HBJ7.
SOURCEi Search...

Gene expression databases

Bgeei Q9HBJ7.
CleanExi HS_USP29.
ExpressionAtlasi Q9HBJ7. baseline.
Genevestigatori Q9HBJ7.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4."
    Kim J., Noskov V.N., Lu X., Bergmann A., Ren X., Warth T., Richardson P., Kouprina N., Stubbs L.
    Genome Res. 10:1138-1147(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiUBP29_HUMAN
AccessioniPrimary (citable) accession number: Q9HBJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3