Q9HBJ7 (UBP29_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 29
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 29
Ubiquitin thioesterase 29
Ubiquitin-specific-processing protease 29

Gene names

Name:

USP29

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	922 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Sequence similarities	Belongs to the peptidase C19 family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Polymorphism
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular protein modification process Non-traceable author statement. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 922	922	Ubiquitin carboxyl-terminal hydrolase 29		PRO_0000080660
Sites
	Active site	294	1	Nucleophile By similarity
	Active site	840	1	Proton acceptor By similarity
Natural variations
	Natural variant	368	1	N → S. Corresponds to variant rs1027392 [ dbSNP | Ensembl ].		VAR_024590
	Natural variant	586	1	E → K. Corresponds to variant rs3795003 [ dbSNP | Ensembl ].		VAR_022055

Sequences

	Sequence		Length	Mass (Da)
	Q9HBJ7 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 122B56AE6FFFF364	FASTA	922	104,156
	10 20 30 40 50 60 MISLKVCGFI QIWSQKTGMT KLKEALIETV QRQKEIKLVV TFKSGKFIRI FQLSNNIRSV 70 80 90 100 110 120 VLRHCKKRQS HLRLTLKNNV FLFIDKLSYR DAKQLNMFLD IIHQNKSQQP MKSDDDWSVF 130 140 150 160 170 180 ESRNMLKEID KTSFYSICNK PSYQKMPLFM SKSPTHVKKG ILENQGGKGQ NTLSSDVQTN 190 200 210 220 230 240 EDILKEDNPV PNKKYKTDSL KYIQSNRKNP SSLEDLEKDR DLKLGPSFNT NCNGNPNLDE 250 260 270 280 290 300 TVLATQTLNA KNGLTSPLEP EHSQGDPRCN KAQVPLDSHS QQLQQGFPNL GNTCYMNAVL 310 320 330 340 350 360 QSLFAIPSFA DDLLTQGVPW EYIPFEALIM TLTQLLALKD FCSTKIKREL LGNVKKVISA 370 380 390 400 410 420 VAEIFSGNMQ NDAHEFLGQC LDQLKEDMEK LNATLNTGKE CGDENSSPQM HVGSAATKVF 430 440 450 460 470 480 VCPVVANFEF ELQLSLICKA CGHAVLKVEP NNYLSINLHQ ETKPLPLSIQ NSLDLFFKEE 490 500 510 520 530 540 ELEYNCQMCK QKSCVARHTF SRLSRVLIIH LKRYSFNNAW LLVKNNEQVY IPKSLSLSSY 550 560 570 580 590 600 CNESTKPPLP LSSSAPVGKC EVLEVSQEMI SEINSPLTPS MKLTSESSDS LVLPVEPDKN 610 620 630 640 650 660 ADLQRFQRDC GDASQEQHQR DLENGSALES ELVHFRDRAI GEKELPVADS LMDQGDISLP 670 680 690 700 710 720 VMYEDGGKLI SSPDTRLVEV HLQEVPQHPE LQKYEKTNTF VEFNFDSVTE STNGFYDCKE 730 740 750 760 770 780 NRIPEGSQGM AEQLQQCIEE SIIDEFLQQA PPPGVRKLDA QEHTEETLNQ STELRLQKAD 790 800 810 820 830 840 LNHLGALGSD NPGNKNILDA ENTRGEAKEL TRNVKMGDPL QAYRLISVVS HIGSSPNSGH 850 860 870 880 890 900 YISDVYDFQK QAWFTYNDLC VSEISETKMQ EARLHSGYIF FYMHNGIFEE LLRKAENSRL 910 920 PSTQAGVIPQ GEYEGDSLYR PA

References

[1]

"Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4." Kim J., Noskov V.N., Lu X., Bergmann A., Ren X., Warth T., Richardson P., Kouprina N., Stubbs L. Genome Res. 10:1138-1147(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF229438 mRNA. Translation: AAG10401.1.
IPI	IPI00011245.
RefSeq	NP_065954.1. NM_020903.2.
UniGene	Hs.515632.
3D structure databases
ProteinModelPortal	Q9HBJ7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HBJ7. 1 interaction.
STRING	9606.ENSP00000254181.
Protein family/group databases
MEROPS	C19.040.
PTM databases
PhosphoSite	Q9HBJ7.
Polymorphism databases
DMDM	23396891.
Proteomic databases
PaxDb	Q9HBJ7.
PRIDE	Q9HBJ7.
Protocols and materials databases
DNASU	57663.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254181; ENSP00000254181; ENSG00000131864. ENST00000598197; ENSP00000470747; ENSG00000131864.
GeneID	57663.
KEGG	hsa:57663.
UCSC	uc002qny.3. human.
Organism-specific databases
CTD	57663.
GeneCards	GC19P057631.
HGNC	HGNC:18563. USP29.
HPA	HPA021064.
MIM	609546. gene.
neXtProt	NX_Q9HBJ7.
PharmGKB	PA38349.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5560.
HOGENOM	HOG000060197.
HOVERGEN	HBG055893.
InParanoid	Q9HBJ7.
KO	K11850.
OMA	VFVCPVV.
OrthoDB	EOG49P9XV.
PhylomeDB	Q9HBJ7.
Gene expression databases
ArrayExpress	Q9HBJ7.
Bgee	Q9HBJ7.
CleanEx	HS_USP29.
Genevestigator	Q9HBJ7.
GermOnline	ENSG00000131864. Homo sapiens.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57663.
NextBio	64438.
SOURCE	Search...

Entry information

Entry name

UBP29_HUMAN

Accession

Primary (citable) accession number: Q9HBJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.