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Q9HBJ0

- PLAC1_HUMAN

UniProt

Q9HBJ0 - PLAC1_HUMAN

Protein

Placenta-specific protein 1

Gene

PLAC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May play a role in placental development.1 Publication

    GO - Biological processi

    1. placenta development Source: UniProtKB
    2. spongiotrophoblast layer developmental growth Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Placenta-specific protein 1
    Gene namesi
    Name:PLAC1Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:9044. PLAC1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33371.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 212190Placenta-specific protein 1Sequence AnalysisPRO_0000251144Add
    BLAST

    Proteomic databases

    PaxDbiQ9HBJ0.
    PRIDEiQ9HBJ0.

    PTM databases

    PhosphoSiteiQ9HBJ0.

    Expressioni

    Tissue specificityi

    Expressed in placenta. Localizes primarily to differentiated syncytiotrophoblast throughout gestation as well as to a small population of villous cytotrophoblasts. Also detected in maternal blood and rapidly disappears following delivery, but is not detected in other adult or fetal tissues examined.4 Publications

    Inductioni

    Up-regulated during trophoblast differentiation and by FGF7 in trophoblast cells.2 Publications

    Gene expression databases

    BgeeiQ9HBJ0.
    CleanExiHS_PLAC1.
    GenevestigatoriQ9HBJ0.

    Organism-specific databases

    HPAiHPA063425.

    Interactioni

    Protein-protein interaction databases

    BioGridi115981. 1 interaction.
    STRINGi9606.ENSP00000352173.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HBJ0.
    SMRiQ9HBJ0. Positions 24-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PLAC1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44687.
    HOGENOMiHOG000049283.
    HOVERGENiHBG080610.
    InParanoidiQ9HBJ0.
    OMAiFHELHLG.
    OrthoDBiEOG73JKWP.
    PhylomeDBiQ9HBJ0.
    TreeFamiTF338479.

    Family and domain databases

    InterProiIPR001507. ZP_dom.
    [Graphical view]
    PfamiPF00100. Zona_pellucida. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9HBJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVFKFIGLM ILLTSAFSAG SGQSPMTVLC SIDWFMVTVH PFMLNNDVCV    50
    HFHELHLGLG CPPNHVQPHA YQFTYRVTEC GIRAKAVSQD MVIYSTEIHY 100
    SSKGTPSKFV IPVSCAAPQK SPWLTKPCSM RVASKSRATA QKDEKCYEVF 150
    SLSQSSQRPN CDCPPCVFSE EEHTQVPCHQ AGAQEAQPLQ PSHFLDISED 200
    WSLHTDDMIG SM 212
    Length:212
    Mass (Da):23,616
    Last modified:March 1, 2001 - v1
    Checksum:iD449300A597DD023
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF234654 mRNA. Translation: AAG22596.1.
    AK075086 mRNA. Translation: BAC11392.1.
    BC022335 mRNA. Translation: AAH22335.1.
    BC066327 mRNA. Translation: AAH66327.1.
    CCDSiCCDS14642.1.
    RefSeqiNP_068568.1. NM_021796.3.
    UniGeneiHs.496811.

    Genome annotation databases

    EnsembliENST00000359237; ENSP00000352173; ENSG00000170965.
    GeneIDi10761.
    KEGGihsa:10761.
    UCSCiuc004exo.1. human.

    Polymorphism databases

    DMDMi74734251.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF234654 mRNA. Translation: AAG22596.1 .
    AK075086 mRNA. Translation: BAC11392.1 .
    BC022335 mRNA. Translation: AAH22335.1 .
    BC066327 mRNA. Translation: AAH66327.1 .
    CCDSi CCDS14642.1.
    RefSeqi NP_068568.1. NM_021796.3.
    UniGenei Hs.496811.

    3D structure databases

    ProteinModelPortali Q9HBJ0.
    SMRi Q9HBJ0. Positions 24-195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115981. 1 interaction.
    STRINGi 9606.ENSP00000352173.

    PTM databases

    PhosphoSitei Q9HBJ0.

    Polymorphism databases

    DMDMi 74734251.

    Proteomic databases

    PaxDbi Q9HBJ0.
    PRIDEi Q9HBJ0.

    Protocols and materials databases

    DNASUi 10761.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359237 ; ENSP00000352173 ; ENSG00000170965 .
    GeneIDi 10761.
    KEGGi hsa:10761.
    UCSCi uc004exo.1. human.

    Organism-specific databases

    CTDi 10761.
    GeneCardsi GC0XM133699.
    HGNCi HGNC:9044. PLAC1.
    HPAi HPA063425.
    MIMi 300296. gene.
    neXtProti NX_Q9HBJ0.
    PharmGKBi PA33371.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44687.
    HOGENOMi HOG000049283.
    HOVERGENi HBG080610.
    InParanoidi Q9HBJ0.
    OMAi FHELHLG.
    OrthoDBi EOG73JKWP.
    PhylomeDBi Q9HBJ0.
    TreeFami TF338479.

    Miscellaneous databases

    GeneWikii PLAC1.
    GenomeRNAii 10761.
    NextBioi 40863.
    PROi Q9HBJ0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9HBJ0.
    CleanExi HS_PLAC1.
    Genevestigatori Q9HBJ0.

    Family and domain databases

    InterProi IPR001507. ZP_dom.
    [Graphical view ]
    Pfami PF00100. Zona_pellucida. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PlacentaImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PlacentaImported.
    4. "PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor."
      Fant M., Weisoly D.L., Cocchia M., Huber R., Khan S., Lunt T., Schlessinger D.
      Mol. Reprod. Dev. 63:430-436(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.
    5. "Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery."
      Concu M., Banzola I., Farina A., Sekizawa A., Rizzo N., Marini M., Caramelli E., Carinci P.
      Fetal Diagn. Ther. 20:27-30(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis."
      Massabbal E., Parveen S., Weisoly D.L., Nelson D.M., Smith S.D., Fant M.
      Mol. Reprod. Dev. 71:299-304(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiPLAC1_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3