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Q9HBJ0 (PLAC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Placenta-specific protein 1
Gene names
Name:PLAC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in placental development. Ref.1

Subcellular location

Secreted Probable.

Tissue specificity

Expressed in placenta. Localizes primarily to differentiated syncytiotrophoblast throughout gestation as well as to a small population of villous cytotrophoblasts. Also detected in maternal blood and rapidly disappears following delivery, but is not detected in other adult or fetal tissues examined. Ref.1 Ref.4 Ref.5 Ref.6

Induction

Up-regulated during trophoblast differentiation and by FGF7 in trophoblast cells. Ref.4 Ref.6

Sequence similarities

Belongs to the PLAC1 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processplacenta development

Inferred from expression pattern Ref.1. Source: UniProtKB

spongiotrophoblast layer developmental growth

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 212190Placenta-specific protein 1
PRO_0000251144

Sequences

Sequence LengthMass (Da)Tools
Q9HBJ0 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: D449300A597DD023

FASTA21223,616
        10         20         30         40         50         60 
MKVFKFIGLM ILLTSAFSAG SGQSPMTVLC SIDWFMVTVH PFMLNNDVCV HFHELHLGLG 

        70         80         90        100        110        120 
CPPNHVQPHA YQFTYRVTEC GIRAKAVSQD MVIYSTEIHY SSKGTPSKFV IPVSCAAPQK 

       130        140        150        160        170        180 
SPWLTKPCSM RVASKSRATA QKDEKCYEVF SLSQSSQRPN CDCPPCVFSE EEHTQVPCHQ 

       190        200        210 
AGAQEAQPLQ PSHFLDISED WSLHTDDMIG SM 

« Hide

References

« Hide 'large scale' references
[1]"PLAC1, an Xq26 gene with placenta-specific expression."
Cocchia M., Huber R., Pantano S., Chen E.Y., Ma P., Forabosco A., Ko M.S.H., Schlessinger D.
Genomics 68:305-312(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor."
Fant M., Weisoly D.L., Cocchia M., Huber R., Khan S., Lunt T., Schlessinger D.
Mol. Reprod. Dev. 63:430-436(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INDUCTION.
[5]"Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery."
Concu M., Banzola I., Farina A., Sekizawa A., Rizzo N., Marini M., Caramelli E., Carinci P.
Fetal Diagn. Ther. 20:27-30(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis."
Massabbal E., Parveen S., Weisoly D.L., Nelson D.M., Smith S.D., Fant M.
Mol. Reprod. Dev. 71:299-304(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INDUCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF234654 mRNA. Translation: AAG22596.1.
AK075086 mRNA. Translation: BAC11392.1.
BC022335 mRNA. Translation: AAH22335.1.
BC066327 mRNA. Translation: AAH66327.1.
CCDSCCDS14642.1.
RefSeqNP_068568.1. NM_021796.3.
UniGeneHs.496811.

3D structure databases

ProteinModelPortalQ9HBJ0.
SMRQ9HBJ0. Positions 24-195.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115981. 1 interaction.
STRING9606.ENSP00000352173.

PTM databases

PhosphoSiteQ9HBJ0.

Polymorphism databases

DMDM74734251.

Proteomic databases

PaxDbQ9HBJ0.
PRIDEQ9HBJ0.

Protocols and materials databases

DNASU10761.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359237; ENSP00000352173; ENSG00000170965.
GeneID10761.
KEGGhsa:10761.
UCSCuc004exo.1. human.

Organism-specific databases

CTD10761.
GeneCardsGC0XM133699.
HGNCHGNC:9044. PLAC1.
HPAHPA063425.
MIM300296. gene.
neXtProtNX_Q9HBJ0.
PharmGKBPA33371.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44687.
HOGENOMHOG000049283.
HOVERGENHBG080610.
InParanoidQ9HBJ0.
OMAFHELHLG.
OrthoDBEOG73JKWP.
PhylomeDBQ9HBJ0.
TreeFamTF338479.

Gene expression databases

BgeeQ9HBJ0.
CleanExHS_PLAC1.
GenevestigatorQ9HBJ0.

Family and domain databases

InterProIPR001507. ZP_dom.
[Graphical view]
PfamPF00100. Zona_pellucida. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPLAC1.
GenomeRNAi10761.
NextBio40863.
PROQ9HBJ0.
SOURCESearch...

Entry information

Entry namePLAC1_HUMAN
AccessionPrimary (citable) accession number: Q9HBJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM