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Protein

Placenta-specific protein 1

Gene

PLAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in placental development.1 Publication

GO - Biological processi

  • placenta development Source: UniProtKB
  • spongiotrophoblast layer developmental growth Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Placenta-specific protein 1
Gene namesi
Name:PLAC1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:9044. PLAC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33371.

Polymorphism and mutation databases

BioMutaiPLAC1.
DMDMi74734251.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 212190Placenta-specific protein 1Sequence AnalysisPRO_0000251144Add
BLAST

Proteomic databases

MaxQBiQ9HBJ0.
PaxDbiQ9HBJ0.
PRIDEiQ9HBJ0.

PTM databases

PhosphoSiteiQ9HBJ0.

Expressioni

Tissue specificityi

Expressed in placenta. Localizes primarily to differentiated syncytiotrophoblast throughout gestation as well as to a small population of villous cytotrophoblasts. Also detected in maternal blood and rapidly disappears following delivery, but is not detected in other adult or fetal tissues examined.4 Publications

Inductioni

Up-regulated during trophoblast differentiation and by FGF7 in trophoblast cells.2 Publications

Gene expression databases

BgeeiQ9HBJ0.
CleanExiHS_PLAC1.
GenevisibleiQ9HBJ0. HS.

Organism-specific databases

HPAiHPA063425.

Interactioni

Protein-protein interaction databases

BioGridi115981. 18 interactions.
STRINGi9606.ENSP00000352173.

Structurei

3D structure databases

ProteinModelPortaliQ9HBJ0.
SMRiQ9HBJ0. Positions 24-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PLAC1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44687.
GeneTreeiENSGT00530000064049.
HOGENOMiHOG000049283.
HOVERGENiHBG080610.
InParanoidiQ9HBJ0.
OMAiTVHPFML.
OrthoDBiEOG73JKWP.
PhylomeDBiQ9HBJ0.
TreeFamiTF338479.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HBJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVFKFIGLM ILLTSAFSAG SGQSPMTVLC SIDWFMVTVH PFMLNNDVCV
60 70 80 90 100
HFHELHLGLG CPPNHVQPHA YQFTYRVTEC GIRAKAVSQD MVIYSTEIHY
110 120 130 140 150
SSKGTPSKFV IPVSCAAPQK SPWLTKPCSM RVASKSRATA QKDEKCYEVF
160 170 180 190 200
SLSQSSQRPN CDCPPCVFSE EEHTQVPCHQ AGAQEAQPLQ PSHFLDISED
210
WSLHTDDMIG SM
Length:212
Mass (Da):23,616
Last modified:March 1, 2001 - v1
Checksum:iD449300A597DD023
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF234654 mRNA. Translation: AAG22596.1.
AK075086 mRNA. Translation: BAC11392.1.
BC022335 mRNA. Translation: AAH22335.1.
BC066327 mRNA. Translation: AAH66327.1.
CCDSiCCDS14642.1.
RefSeqiNP_068568.1. NM_021796.3.
XP_011529557.1. XM_011531255.1.
XP_011529558.1. XM_011531256.1.
XP_011529559.1. XM_011531257.1.
XP_011529560.1. XM_011531258.1.
XP_011529561.1. XM_011531259.1.
XP_011529562.1. XM_011531260.1.
XP_011529563.1. XM_011531261.1.
XP_011529564.1. XM_011531262.1.
XP_011529565.1. XM_011531263.1.
UniGeneiHs.496811.

Genome annotation databases

EnsembliENST00000359237; ENSP00000352173; ENSG00000170965.
GeneIDi10761.
KEGGihsa:10761.
UCSCiuc004exo.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF234654 mRNA. Translation: AAG22596.1.
AK075086 mRNA. Translation: BAC11392.1.
BC022335 mRNA. Translation: AAH22335.1.
BC066327 mRNA. Translation: AAH66327.1.
CCDSiCCDS14642.1.
RefSeqiNP_068568.1. NM_021796.3.
XP_011529557.1. XM_011531255.1.
XP_011529558.1. XM_011531256.1.
XP_011529559.1. XM_011531257.1.
XP_011529560.1. XM_011531258.1.
XP_011529561.1. XM_011531259.1.
XP_011529562.1. XM_011531260.1.
XP_011529563.1. XM_011531261.1.
XP_011529564.1. XM_011531262.1.
XP_011529565.1. XM_011531263.1.
UniGeneiHs.496811.

3D structure databases

ProteinModelPortaliQ9HBJ0.
SMRiQ9HBJ0. Positions 24-195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115981. 18 interactions.
STRINGi9606.ENSP00000352173.

PTM databases

PhosphoSiteiQ9HBJ0.

Polymorphism and mutation databases

BioMutaiPLAC1.
DMDMi74734251.

Proteomic databases

MaxQBiQ9HBJ0.
PaxDbiQ9HBJ0.
PRIDEiQ9HBJ0.

Protocols and materials databases

DNASUi10761.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359237; ENSP00000352173; ENSG00000170965.
GeneIDi10761.
KEGGihsa:10761.
UCSCiuc004exo.1. human.

Organism-specific databases

CTDi10761.
GeneCardsiGC0XM133699.
HGNCiHGNC:9044. PLAC1.
HPAiHPA063425.
MIMi300296. gene.
neXtProtiNX_Q9HBJ0.
PharmGKBiPA33371.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44687.
GeneTreeiENSGT00530000064049.
HOGENOMiHOG000049283.
HOVERGENiHBG080610.
InParanoidiQ9HBJ0.
OMAiTVHPFML.
OrthoDBiEOG73JKWP.
PhylomeDBiQ9HBJ0.
TreeFamiTF338479.

Miscellaneous databases

ChiTaRSiPLAC1. human.
GeneWikiiPLAC1.
GenomeRNAii10761.
NextBioi40863.
PROiQ9HBJ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HBJ0.
CleanExiHS_PLAC1.
GenevisibleiQ9HBJ0. HS.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PlacentaImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PlacentaImported.
  4. "PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor."
    Fant M., Weisoly D.L., Cocchia M., Huber R., Khan S., Lunt T., Schlessinger D.
    Mol. Reprod. Dev. 63:430-436(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  5. "Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery."
    Concu M., Banzola I., Farina A., Sekizawa A., Rizzo N., Marini M., Caramelli E., Carinci P.
    Fetal Diagn. Ther. 20:27-30(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis."
    Massabbal E., Parveen S., Weisoly D.L., Nelson D.M., Smith S.D., Fant M.
    Mol. Reprod. Dev. 71:299-304(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiPLAC1_HUMAN
AccessioniPrimary (citable) accession number: Q9HBJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.