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Q9HBJ0

- PLAC1_HUMAN

UniProt

Q9HBJ0 - PLAC1_HUMAN

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Protein

Placenta-specific protein 1

Gene
PLAC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in placental development.1 Publication

GO - Biological processi

  1. placenta development Source: UniProtKB
  2. spongiotrophoblast layer developmental growth Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Placenta-specific protein 1
Gene namesi
Name:PLAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:9044. PLAC1.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 212190Placenta-specific protein 1PRO_0000251144Add
BLAST

Proteomic databases

PaxDbiQ9HBJ0.
PRIDEiQ9HBJ0.

PTM databases

PhosphoSiteiQ9HBJ0.

Expressioni

Tissue specificityi

Expressed in placenta. Localizes primarily to differentiated syncytiotrophoblast throughout gestation as well as to a small population of villous cytotrophoblasts. Also detected in maternal blood and rapidly disappears following delivery, but is not detected in other adult or fetal tissues examined.4 Publications

Inductioni

Up-regulated during trophoblast differentiation and by FGF7 in trophoblast cells.2 Publications

Gene expression databases

BgeeiQ9HBJ0.
CleanExiHS_PLAC1.
GenevestigatoriQ9HBJ0.

Organism-specific databases

HPAiHPA063425.

Interactioni

Protein-protein interaction databases

BioGridi115981. 1 interaction.
STRINGi9606.ENSP00000352173.

Structurei

3D structure databases

ProteinModelPortaliQ9HBJ0.
SMRiQ9HBJ0. Positions 24-195.

Family & Domainsi

Sequence similaritiesi

Belongs to the PLAC1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44687.
HOGENOMiHOG000049283.
HOVERGENiHBG080610.
InParanoidiQ9HBJ0.
OMAiFHELHLG.
OrthoDBiEOG73JKWP.
PhylomeDBiQ9HBJ0.
TreeFamiTF338479.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HBJ0-1 [UniParc]FASTAAdd to Basket

« Hide

MKVFKFIGLM ILLTSAFSAG SGQSPMTVLC SIDWFMVTVH PFMLNNDVCV    50
HFHELHLGLG CPPNHVQPHA YQFTYRVTEC GIRAKAVSQD MVIYSTEIHY 100
SSKGTPSKFV IPVSCAAPQK SPWLTKPCSM RVASKSRATA QKDEKCYEVF 150
SLSQSSQRPN CDCPPCVFSE EEHTQVPCHQ AGAQEAQPLQ PSHFLDISED 200
WSLHTDDMIG SM 212
Length:212
Mass (Da):23,616
Last modified:March 1, 2001 - v1
Checksum:iD449300A597DD023
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF234654 mRNA. Translation: AAG22596.1.
AK075086 mRNA. Translation: BAC11392.1.
BC022335 mRNA. Translation: AAH22335.1.
BC066327 mRNA. Translation: AAH66327.1.
CCDSiCCDS14642.1.
RefSeqiNP_068568.1. NM_021796.3.
UniGeneiHs.496811.

Genome annotation databases

EnsembliENST00000359237; ENSP00000352173; ENSG00000170965.
GeneIDi10761.
KEGGihsa:10761.
UCSCiuc004exo.1. human.

Polymorphism databases

DMDMi74734251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF234654 mRNA. Translation: AAG22596.1 .
AK075086 mRNA. Translation: BAC11392.1 .
BC022335 mRNA. Translation: AAH22335.1 .
BC066327 mRNA. Translation: AAH66327.1 .
CCDSi CCDS14642.1.
RefSeqi NP_068568.1. NM_021796.3.
UniGenei Hs.496811.

3D structure databases

ProteinModelPortali Q9HBJ0.
SMRi Q9HBJ0. Positions 24-195.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115981. 1 interaction.
STRINGi 9606.ENSP00000352173.

PTM databases

PhosphoSitei Q9HBJ0.

Polymorphism databases

DMDMi 74734251.

Proteomic databases

PaxDbi Q9HBJ0.
PRIDEi Q9HBJ0.

Protocols and materials databases

DNASUi 10761.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359237 ; ENSP00000352173 ; ENSG00000170965 .
GeneIDi 10761.
KEGGi hsa:10761.
UCSCi uc004exo.1. human.

Organism-specific databases

CTDi 10761.
GeneCardsi GC0XM133699.
HGNCi HGNC:9044. PLAC1.
HPAi HPA063425.
MIMi 300296. gene.
neXtProti NX_Q9HBJ0.
PharmGKBi PA33371.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44687.
HOGENOMi HOG000049283.
HOVERGENi HBG080610.
InParanoidi Q9HBJ0.
OMAi FHELHLG.
OrthoDBi EOG73JKWP.
PhylomeDBi Q9HBJ0.
TreeFami TF338479.

Miscellaneous databases

GeneWikii PLAC1.
GenomeRNAii 10761.
NextBioi 40863.
PROi Q9HBJ0.
SOURCEi Search...

Gene expression databases

Bgeei Q9HBJ0.
CleanExi HS_PLAC1.
Genevestigatori Q9HBJ0.

Family and domain databases

InterProi IPR001507. ZP_dom.
[Graphical view ]
Pfami PF00100. Zona_pellucida. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor."
    Fant M., Weisoly D.L., Cocchia M., Huber R., Khan S., Lunt T., Schlessinger D.
    Mol. Reprod. Dev. 63:430-436(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  5. "Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery."
    Concu M., Banzola I., Farina A., Sekizawa A., Rizzo N., Marini M., Caramelli E., Carinci P.
    Fetal Diagn. Ther. 20:27-30(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis."
    Massabbal E., Parveen S., Weisoly D.L., Nelson D.M., Smith S.D., Fant M.
    Mol. Reprod. Dev. 71:299-304(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiPLAC1_HUMAN
AccessioniPrimary (citable) accession number: Q9HBJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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