Q9HBI6 (CP4FB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 4F11
EC=1.14.14.1

Alternative name(s):
CYPIVF11

Gene names

Name:

CYP4F11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Microsome membrane; Single-pass membrane protein By similarity.
Tissue specificity	Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle. Ref.1
Sequence similarities	Belongs to the cytochrome P450 family.
Sequence caution	The sequence AAC27731.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	inflammatory response Traceable author statement Ref.1. Source: UniProtKB small molecule metabolic process Traceable author statement. Source: Reactome xenobiotic metabolic process Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Traceable author statement Ref.1. Source: UniProtKB iron ion binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 524	524	Cytochrome P450 4F11		PRO_0000051856
Regions
	Transmembrane	15 – 37	23	Helical; Potential
Sites
	Metal binding	468	1	Iron (heme axial ligand) By similarity
	Binding site	328	1	Heme (covalent; via 1 link) By similarity
Natural variations
	Natural variant	146	1	R → C. Corresponds to variant rs57519667 [ dbSNP | Ensembl ].		VAR_060265
	Natural variant	276	1	C → R. Ref.1 Ref.3 Corresponds to variant rs8104361 [ dbSNP | Ensembl ].		VAR_060266
	Natural variant	284	1	D → N. Corresponds to variant rs1060463 [ dbSNP | Ensembl ].		VAR_060267
Experimental info
	Sequence conflict	446	1	D → N in AAG15889. Ref.1
	Sequence conflict	446	1	D → N in AAH16853. Ref.3
	Sequence conflict	496	1	T → I in AAG15889. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9HBI6 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 8B0F14C52E657CB2	FASTA	524	60,146
	10 20 30 40 50 60 MPQLSLSWLG LGPVAASPWL LLLLVGGSWL LARVLAWTYT FYDNCRRLQC FPQPPKQNWF 70 80 90 100 110 120 WGHQGLVTPT EEGMKTLTQL VTTYPQGFKL WLGPTFPLLI LCHPDIIRPI TSASAAVAPK 130 140 150 160 170 180 DMIFYGFLKP WLGDGLLLSG GDKWSRHRRM LTPAFHFNIL KPYMKIFNKS VNIMHDKWQR 190 200 210 220 230 240 LASEGSARLD MFEHISLMTL DSLQKCVFSF ESNCQEKPSE YIAAILELSA FVEKRNQQIL 250 260 270 280 290 300 LHTDFLYYLT PDGQRFRRAC HLVHDFTDAV IQERRCTLPT QGIDDFLKNK AKSKTLDFID 310 320 330 340 350 360 VLLLSKDEDG KELSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QEQCRQEVQE 370 380 390 400 410 420 LLKDREPIEI EWDDLAQLPF LTMCIKESLR LHPPVPVISR CCTQDFVLPD GRVIPKGIVC 430 440 450 460 470 480 LINIIGIHYN PTVWPDPEVY DPFRFDQENI KERSPLAFIP FSAGPRNCIG QAFAMAEMKV 490 500 510 520 VLALTLLHFR ILPTHTEPRR KPELILRAEG GLWLRVEPLG ANSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization." Cui X., Nelson D.R., Strobel H.W. Genomics 68:161-166(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ARG-276. Tissue: Brain and Liver.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-276. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF236085 mRNA. Translation: AAG15889.1. AC005336 Genomic DNA. Translation: AAC27731.1. Sequence problems. AC020950 Genomic DNA. No translation available. AC011517 Genomic DNA. No translation available. BC016853 mRNA. Translation: AAH16853.1.
IPI	IPI00307483.
RefSeq	NP_001122404.1. NM_001128932.1. NP_067010.3. NM_021187.3.
UniGene	Hs.187393.
3D structure databases
ProteinModelPortal	Q9HBI6.
SMR	Q9HBI6. Positions 97-510.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HBI6. 1 interaction.
STRING	9606.ENSP00000248041.
PTM databases
PhosphoSite	Q9HBI6.
Polymorphism databases
DMDM	296439388.
Proteomic databases
PaxDb	Q9HBI6.
PRIDE	Q9HBI6.
Protocols and materials databases
DNASU	57834.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000248041; ENSP00000248041; ENSG00000171903. ENST00000402119; ENSP00000384588; ENSG00000171903.
GeneID	57834.
KEGG	hsa:57834.
UCSC	uc002nbt.2. human.
Organism-specific databases
CTD	57834.
GeneCards	GC19M016023.
H-InvDB	HIX0014857.
HGNC	HGNC:13265. CYP4F11.
HPA	HPA017265.
MIM	611517. gene.
neXtProt	NX_Q9HBI6.
PharmGKB	PA27120.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2124.
HOGENOM	HOG000233833.
HOVERGEN	HBG000182.
InParanoid	Q9HBI6.
KO	K00490.
OMA	EPLGANS.
OrthoDB	EOG4Q58P4.
PhylomeDB	Q9HBI6.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q9HBI6.
Bgee	Q9HBI6.
CleanEx	HS_CYP4F11.
Genevestigator	Q9HBI6.
GermOnline	ENSG00000171903. Homo sapiens.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57834.
NextBio	64827.
SOURCE	Search...

Entry information

Entry name

CP4FB_HUMAN

Accession

Primary (citable) accession number: Q9HBI6
Secondary accession number(s): O75254, Q96AQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 115 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.