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Q9HBI6 (CP4FB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 4F11

EC=1.14.14.1
Alternative name(s):
CYPIVF11
Gene names
Name:CYP4F11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length524 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Microsome membrane; Single-pass membrane protein By similarity.

Tissue specificity

Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle. Ref.1

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence caution

The sequence AAC27731.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 524524Cytochrome P450 4F11
PRO_0000051856

Regions

Transmembrane15 – 3723Helical; Potential

Sites

Metal binding4681Iron (heme axial ligand) By similarity
Binding site3281Heme (covalent; via 1 link) By similarity

Natural variations

Natural variant1461R → C.
Corresponds to variant rs57519667 [ dbSNP | Ensembl ].
VAR_060265
Natural variant2761C → R. Ref.1 Ref.3
Corresponds to variant rs8104361 [ dbSNP | Ensembl ].
VAR_060266
Natural variant2841D → N.
Corresponds to variant rs1060463 [ dbSNP | Ensembl ].
VAR_060267

Experimental info

Sequence conflict4461D → N in AAG15889. Ref.1
Sequence conflict4461D → N in AAH16853. Ref.3
Sequence conflict4961T → I in AAG15889. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9HBI6 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 8B0F14C52E657CB2

FASTA52460,146
        10         20         30         40         50         60 
MPQLSLSWLG LGPVAASPWL LLLLVGGSWL LARVLAWTYT FYDNCRRLQC FPQPPKQNWF 

        70         80         90        100        110        120 
WGHQGLVTPT EEGMKTLTQL VTTYPQGFKL WLGPTFPLLI LCHPDIIRPI TSASAAVAPK 

       130        140        150        160        170        180 
DMIFYGFLKP WLGDGLLLSG GDKWSRHRRM LTPAFHFNIL KPYMKIFNKS VNIMHDKWQR 

       190        200        210        220        230        240 
LASEGSARLD MFEHISLMTL DSLQKCVFSF ESNCQEKPSE YIAAILELSA FVEKRNQQIL 

       250        260        270        280        290        300 
LHTDFLYYLT PDGQRFRRAC HLVHDFTDAV IQERRCTLPT QGIDDFLKNK AKSKTLDFID 

       310        320        330        340        350        360 
VLLLSKDEDG KELSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QEQCRQEVQE 

       370        380        390        400        410        420 
LLKDREPIEI EWDDLAQLPF LTMCIKESLR LHPPVPVISR CCTQDFVLPD GRVIPKGIVC 

       430        440        450        460        470        480 
LINIIGIHYN PTVWPDPEVY DPFRFDQENI KERSPLAFIP FSAGPRNCIG QAFAMAEMKV 

       490        500        510        520 
VLALTLLHFR ILPTHTEPRR KPELILRAEG GLWLRVEPLG ANSQ 

« Hide

References

« Hide 'large scale' references
[1]"A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization."
Cui X., Nelson D.R., Strobel H.W.
Genomics 68:161-166(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ARG-276.
Tissue: Brain and Liver.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-276.
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF236085 mRNA. Translation: AAG15889.1.
AC005336 Genomic DNA. Translation: AAC27731.1. Sequence problems.
AC020950 Genomic DNA. No translation available.
AC011517 Genomic DNA. No translation available.
BC016853 mRNA. Translation: AAH16853.1.
RefSeqNP_001122404.1. NM_001128932.1.
NP_067010.3. NM_021187.3.
UniGeneHs.187393.

3D structure databases

ProteinModelPortalQ9HBI6.
SMRQ9HBI6. Positions 97-510.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121790. 2 interactions.
IntActQ9HBI6. 1 interaction.
STRING9606.ENSP00000248041.

PTM databases

PhosphoSiteQ9HBI6.

Polymorphism databases

DMDM296439388.

Proteomic databases

PaxDbQ9HBI6.
PRIDEQ9HBI6.

Protocols and materials databases

DNASU57834.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000248041; ENSP00000248041; ENSG00000171903.
ENST00000402119; ENSP00000384588; ENSG00000171903.
GeneID57834.
KEGGhsa:57834.
UCSCuc002nbt.2. human.

Organism-specific databases

CTD57834.
GeneCardsGC19M016023.
H-InvDBHIX0014857.
HGNCHGNC:13265. CYP4F11.
HPAHPA017265.
MIM611517. gene.
neXtProtNX_Q9HBI6.
PharmGKBPA27120.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000233833.
HOVERGENHBG000182.
InParanoidQ9HBI6.
KOK17729.
OMADMIFYGF.
PhylomeDBQ9HBI6.
TreeFamTF105088.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressQ9HBI6.
BgeeQ9HBI6.
CleanExHS_CYP4F11.
GenevestigatorQ9HBI6.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCYP4F11.
GenomeRNAi57834.
NextBio64827.
PROQ9HBI6.
SOURCESearch...

Entry information

Entry nameCP4FB_HUMAN
AccessionPrimary (citable) accession number: Q9HBI6
Secondary accession number(s): O75254, Q96AQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 18, 2010
Last modified: March 19, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM