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Q9HBI6

- CP4FB_HUMAN

UniProt

Q9HBI6 - CP4FB_HUMAN

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Protein
Cytochrome P450 4F11
Gene
CYP4F11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei328 – 3281Heme (covalent; via 1 link) By similarity
Metal bindingi468 – 4681Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. inflammatory response Source: UniProtKB
  2. oxidation-reduction process Source: UniProtKB
  3. small molecule metabolic process Source: Reactome
  4. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13425. Miscellaneous substrates.
REACT_13645. Eicosanoids.
REACT_13814. Fatty acids.
REACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4F11 (EC:1.14.14.1)
Alternative name(s):
CYPIVF11
Gene namesi
Name:CYP4F11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13265. CYP4F11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3723Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27120.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Cytochrome P450 4F11
PRO_0000051856Add
BLAST

Proteomic databases

MaxQBiQ9HBI6.
PaxDbiQ9HBI6.
PRIDEiQ9HBI6.

PTM databases

PhosphoSiteiQ9HBI6.

Expressioni

Tissue specificityi

Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle.1 Publication

Gene expression databases

ArrayExpressiQ9HBI6.
BgeeiQ9HBI6.
CleanExiHS_CYP4F11.
GenevestigatoriQ9HBI6.

Organism-specific databases

HPAiHPA017265.

Interactioni

Protein-protein interaction databases

BioGridi121790. 2 interactions.
IntActiQ9HBI6. 1 interaction.
STRINGi9606.ENSP00000248041.

Structurei

3D structure databases

ProteinModelPortaliQ9HBI6.
SMRiQ9HBI6. Positions 73-520.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiQ9HBI6.
KOiK17729.
OMAiEPLGANS.
PhylomeDBiQ9HBI6.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HBI6-1 [UniParc]FASTAAdd to Basket

« Hide

MPQLSLSWLG LGPVAASPWL LLLLVGGSWL LARVLAWTYT FYDNCRRLQC    50
FPQPPKQNWF WGHQGLVTPT EEGMKTLTQL VTTYPQGFKL WLGPTFPLLI 100
LCHPDIIRPI TSASAAVAPK DMIFYGFLKP WLGDGLLLSG GDKWSRHRRM 150
LTPAFHFNIL KPYMKIFNKS VNIMHDKWQR LASEGSARLD MFEHISLMTL 200
DSLQKCVFSF ESNCQEKPSE YIAAILELSA FVEKRNQQIL LHTDFLYYLT 250
PDGQRFRRAC HLVHDFTDAV IQERRCTLPT QGIDDFLKNK AKSKTLDFID 300
VLLLSKDEDG KELSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY 350
QEQCRQEVQE LLKDREPIEI EWDDLAQLPF LTMCIKESLR LHPPVPVISR 400
CCTQDFVLPD GRVIPKGIVC LINIIGIHYN PTVWPDPEVY DPFRFDQENI 450
KERSPLAFIP FSAGPRNCIG QAFAMAEMKV VLALTLLHFR ILPTHTEPRR 500
KPELILRAEG GLWLRVEPLG ANSQ 524
Length:524
Mass (Da):60,146
Last modified:May 18, 2010 - v3
Checksum:i8B0F14C52E657CB2
GO

Sequence cautioni

The sequence AAC27731.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti146 – 1461R → C.
Corresponds to variant rs57519667 [ dbSNP | Ensembl ].
VAR_060265
Natural varianti276 – 2761C → R.2 Publications
Corresponds to variant rs8104361 [ dbSNP | Ensembl ].
VAR_060266
Natural varianti284 – 2841D → N.
Corresponds to variant rs1060463 [ dbSNP | Ensembl ].
VAR_060267

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti446 – 4461D → N in AAG15889. 1 Publication
Sequence conflicti446 – 4461D → N in AAH16853. 1 Publication
Sequence conflicti496 – 4961T → I in AAG15889. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF236085 mRNA. Translation: AAG15889.1.
AC005336 Genomic DNA. Translation: AAC27731.1. Sequence problems.
AC020950 Genomic DNA. No translation available.
AC011517 Genomic DNA. No translation available.
BC016853 mRNA. Translation: AAH16853.1.
CCDSiCCDS12337.1.
RefSeqiNP_001122404.1. NM_001128932.1.
NP_067010.3. NM_021187.3.
UniGeneiHs.187393.

Genome annotation databases

EnsembliENST00000248041; ENSP00000248041; ENSG00000171903.
ENST00000402119; ENSP00000384588; ENSG00000171903.
GeneIDi57834.
KEGGihsa:57834.
UCSCiuc002nbt.2. human.

Polymorphism databases

DMDMi296439388.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF236085 mRNA. Translation: AAG15889.1 .
AC005336 Genomic DNA. Translation: AAC27731.1 . Sequence problems.
AC020950 Genomic DNA. No translation available.
AC011517 Genomic DNA. No translation available.
BC016853 mRNA. Translation: AAH16853.1 .
CCDSi CCDS12337.1.
RefSeqi NP_001122404.1. NM_001128932.1.
NP_067010.3. NM_021187.3.
UniGenei Hs.187393.

3D structure databases

ProteinModelPortali Q9HBI6.
SMRi Q9HBI6. Positions 73-520.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121790. 2 interactions.
IntActi Q9HBI6. 1 interaction.
STRINGi 9606.ENSP00000248041.

PTM databases

PhosphoSitei Q9HBI6.

Polymorphism databases

DMDMi 296439388.

Proteomic databases

MaxQBi Q9HBI6.
PaxDbi Q9HBI6.
PRIDEi Q9HBI6.

Protocols and materials databases

DNASUi 57834.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000248041 ; ENSP00000248041 ; ENSG00000171903 .
ENST00000402119 ; ENSP00000384588 ; ENSG00000171903 .
GeneIDi 57834.
KEGGi hsa:57834.
UCSCi uc002nbt.2. human.

Organism-specific databases

CTDi 57834.
GeneCardsi GC19M016023.
H-InvDB HIX0014857.
HGNCi HGNC:13265. CYP4F11.
HPAi HPA017265.
MIMi 611517. gene.
neXtProti NX_Q9HBI6.
PharmGKBi PA27120.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000233833.
HOVERGENi HBG000182.
InParanoidi Q9HBI6.
KOi K17729.
OMAi EPLGANS.
PhylomeDBi Q9HBI6.
TreeFami TF105088.

Enzyme and pathway databases

Reactomei REACT_13425. Miscellaneous substrates.
REACT_13645. Eicosanoids.
REACT_13814. Fatty acids.
REACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).

Miscellaneous databases

GeneWikii CYP4F11.
GenomeRNAii 57834.
NextBioi 64827.
PROi Q9HBI6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9HBI6.
Bgeei Q9HBI6.
CleanExi HS_CYP4F11.
Genevestigatori Q9HBI6.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization."
    Cui X., Nelson D.R., Strobel H.W.
    Genomics 68:161-166(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ARG-276.
    Tissue: Brain and Liver.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-276.
    Tissue: Colon.

Entry informationi

Entry nameiCP4FB_HUMAN
AccessioniPrimary (citable) accession number: Q9HBI6
Secondary accession number(s): O75254, Q96AQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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