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Q9HBI6

- CP4FB_HUMAN

UniProt

Q9HBI6 - CP4FB_HUMAN

Protein

Cytochrome P450 4F11

Gene

CYP4F11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei328 – 3281Heme (covalent; via 1 link)By similarity
    Metal bindingi468 – 4681Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. inflammatory response Source: UniProtKB
    2. oxidation-reduction process Source: UniProtKB
    3. small molecule metabolic process Source: Reactome
    4. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_13425. Miscellaneous substrates.
    REACT_13645. Eicosanoids.
    REACT_13814. Fatty acids.
    REACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 4F11 (EC:1.14.14.1)
    Alternative name(s):
    CYPIVF11
    Gene namesi
    Name:CYP4F11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13265. CYP4F11.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27120.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 524524Cytochrome P450 4F11PRO_0000051856Add
    BLAST

    Proteomic databases

    MaxQBiQ9HBI6.
    PaxDbiQ9HBI6.
    PRIDEiQ9HBI6.

    PTM databases

    PhosphoSiteiQ9HBI6.

    Expressioni

    Tissue specificityi

    Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ9HBI6.
    BgeeiQ9HBI6.
    CleanExiHS_CYP4F11.
    GenevestigatoriQ9HBI6.

    Organism-specific databases

    HPAiHPA017265.

    Interactioni

    Protein-protein interaction databases

    BioGridi121790. 2 interactions.
    IntActiQ9HBI6. 1 interaction.
    STRINGi9606.ENSP00000248041.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HBI6.
    SMRiQ9HBI6. Positions 73-520.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000233833.
    HOVERGENiHBG000182.
    InParanoidiQ9HBI6.
    KOiK17729.
    OMAiEPLGANS.
    PhylomeDBiQ9HBI6.
    TreeFamiTF105088.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HBI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPQLSLSWLG LGPVAASPWL LLLLVGGSWL LARVLAWTYT FYDNCRRLQC    50
    FPQPPKQNWF WGHQGLVTPT EEGMKTLTQL VTTYPQGFKL WLGPTFPLLI 100
    LCHPDIIRPI TSASAAVAPK DMIFYGFLKP WLGDGLLLSG GDKWSRHRRM 150
    LTPAFHFNIL KPYMKIFNKS VNIMHDKWQR LASEGSARLD MFEHISLMTL 200
    DSLQKCVFSF ESNCQEKPSE YIAAILELSA FVEKRNQQIL LHTDFLYYLT 250
    PDGQRFRRAC HLVHDFTDAV IQERRCTLPT QGIDDFLKNK AKSKTLDFID 300
    VLLLSKDEDG KELSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY 350
    QEQCRQEVQE LLKDREPIEI EWDDLAQLPF LTMCIKESLR LHPPVPVISR 400
    CCTQDFVLPD GRVIPKGIVC LINIIGIHYN PTVWPDPEVY DPFRFDQENI 450
    KERSPLAFIP FSAGPRNCIG QAFAMAEMKV VLALTLLHFR ILPTHTEPRR 500
    KPELILRAEG GLWLRVEPLG ANSQ 524
    Length:524
    Mass (Da):60,146
    Last modified:May 18, 2010 - v3
    Checksum:i8B0F14C52E657CB2
    GO

    Sequence cautioni

    The sequence AAC27731.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti446 – 4461D → N in AAG15889. (PubMed:10964514)Curated
    Sequence conflicti446 – 4461D → N in AAH16853. (PubMed:15489334)Curated
    Sequence conflicti496 – 4961T → I in AAG15889. (PubMed:10964514)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti146 – 1461R → C.
    Corresponds to variant rs57519667 [ dbSNP | Ensembl ].
    VAR_060265
    Natural varianti276 – 2761C → R.2 Publications
    Corresponds to variant rs8104361 [ dbSNP | Ensembl ].
    VAR_060266
    Natural varianti284 – 2841D → N.
    Corresponds to variant rs1060463 [ dbSNP | Ensembl ].
    VAR_060267

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF236085 mRNA. Translation: AAG15889.1.
    AC005336 Genomic DNA. Translation: AAC27731.1. Sequence problems.
    AC020950 Genomic DNA. No translation available.
    AC011517 Genomic DNA. No translation available.
    BC016853 mRNA. Translation: AAH16853.1.
    CCDSiCCDS12337.1.
    RefSeqiNP_001122404.1. NM_001128932.1.
    NP_067010.3. NM_021187.3.
    UniGeneiHs.187393.

    Genome annotation databases

    EnsembliENST00000248041; ENSP00000248041; ENSG00000171903.
    ENST00000402119; ENSP00000384588; ENSG00000171903.
    GeneIDi57834.
    KEGGihsa:57834.
    UCSCiuc002nbt.2. human.

    Polymorphism databases

    DMDMi296439388.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF236085 mRNA. Translation: AAG15889.1 .
    AC005336 Genomic DNA. Translation: AAC27731.1 . Sequence problems.
    AC020950 Genomic DNA. No translation available.
    AC011517 Genomic DNA. No translation available.
    BC016853 mRNA. Translation: AAH16853.1 .
    CCDSi CCDS12337.1.
    RefSeqi NP_001122404.1. NM_001128932.1.
    NP_067010.3. NM_021187.3.
    UniGenei Hs.187393.

    3D structure databases

    ProteinModelPortali Q9HBI6.
    SMRi Q9HBI6. Positions 73-520.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121790. 2 interactions.
    IntActi Q9HBI6. 1 interaction.
    STRINGi 9606.ENSP00000248041.

    PTM databases

    PhosphoSitei Q9HBI6.

    Polymorphism databases

    DMDMi 296439388.

    Proteomic databases

    MaxQBi Q9HBI6.
    PaxDbi Q9HBI6.
    PRIDEi Q9HBI6.

    Protocols and materials databases

    DNASUi 57834.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248041 ; ENSP00000248041 ; ENSG00000171903 .
    ENST00000402119 ; ENSP00000384588 ; ENSG00000171903 .
    GeneIDi 57834.
    KEGGi hsa:57834.
    UCSCi uc002nbt.2. human.

    Organism-specific databases

    CTDi 57834.
    GeneCardsi GC19M016023.
    H-InvDB HIX0014857.
    HGNCi HGNC:13265. CYP4F11.
    HPAi HPA017265.
    MIMi 611517. gene.
    neXtProti NX_Q9HBI6.
    PharmGKBi PA27120.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000233833.
    HOVERGENi HBG000182.
    InParanoidi Q9HBI6.
    KOi K17729.
    OMAi EPLGANS.
    PhylomeDBi Q9HBI6.
    TreeFami TF105088.

    Enzyme and pathway databases

    Reactomei REACT_13425. Miscellaneous substrates.
    REACT_13645. Eicosanoids.
    REACT_13814. Fatty acids.
    REACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).

    Miscellaneous databases

    GeneWikii CYP4F11.
    GenomeRNAii 57834.
    NextBioi 64827.
    PROi Q9HBI6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HBI6.
    Bgeei Q9HBI6.
    CleanExi HS_CYP4F11.
    Genevestigatori Q9HBI6.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization."
      Cui X., Nelson D.R., Strobel H.W.
      Genomics 68:161-166(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ARG-276.
      Tissue: Brain and Liver.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-276.
      Tissue: Colon.

    Entry informationi

    Entry nameiCP4FB_HUMAN
    AccessioniPrimary (citable) accession number: Q9HBI6
    Secondary accession number(s): O75254, Q96AQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3