ID   CEP15_HUMAN             Reviewed;         128 AA.
AC   Q9HBI5; B2R9U0;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 124.
DE   RecName: Full=Centrosomal protein 15 {ECO:0000312|HGNC:HGNC:25024};
DE   AltName: Full=Centrosomal protein 15 kDa {ECO:0000305};
GN   Name=CEP15 {ECO:0000312|HGNC:HGNC:25024}; ORFNames=C3orf14, HT021;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hypothalamus;
RX   PubMed=10931946; DOI=10.1073/pnas.160270997;
RA   Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA   Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA   Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA   Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA   Chen M.-D., Chen J.-L.;
RT   "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT   and full-length cDNA cloning.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thalamus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in ciliary assembly. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000305}.
CC       Note=Locates at ciliary distal appendages. {ECO:0000305}.
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DR   EMBL; AF236158; AAG09750.1; -; mRNA.
DR   EMBL; AK313915; BAG36637.1; -; mRNA.
DR   EMBL; CH471055; EAW65400.1; -; Genomic_DNA.
DR   EMBL; BC017772; AAH17772.1; -; mRNA.
DR   CCDS; CCDS2896.1; -.
DR   RefSeq; NP_001278870.1; NM_001291941.1.
DR   RefSeq; NP_001278871.1; NM_001291942.1.
DR   RefSeq; NP_065736.1; NM_020685.4.
DR   RefSeq; XP_016862420.1; XM_017006931.1.
DR   AlphaFoldDB; Q9HBI5; -.
DR   SMR; Q9HBI5; -.
DR   BioGRID; 121516; 9.
DR   IntAct; Q9HBI5; 3.
DR   STRING; 9606.ENSP00000418086; -.
DR   iPTMnet; Q9HBI5; -.
DR   PhosphoSitePlus; Q9HBI5; -.
DR   BioMuta; C3orf14; -.
DR   DMDM; 68565304; -.
DR   EPD; Q9HBI5; -.
DR   MassIVE; Q9HBI5; -.
DR   MaxQB; Q9HBI5; -.
DR   PaxDb; 9606-ENSP00000418086; -.
DR   PeptideAtlas; Q9HBI5; -.
DR   ProteomicsDB; 81561; -.
DR   Antibodypedia; 54678; 68 antibodies from 10 providers.
DR   DNASU; 57415; -.
DR   Ensembl; ENST00000232519.9; ENSP00000232519.5; ENSG00000114405.11.
DR   Ensembl; ENST00000462069.6; ENSP00000419977.1; ENSG00000114405.11.
DR   Ensembl; ENST00000494481.5; ENSP00000418086.1; ENSG00000114405.11.
DR   Ensembl; ENST00000542214.2; ENSP00000438275.1; ENSG00000114405.11.
DR   GeneID; 57415; -.
DR   KEGG; hsa:57415; -.
DR   MANE-Select; ENST00000462069.6; ENSP00000419977.1; NM_001291941.3; NP_001278870.1.
DR   UCSC; uc003dlf.4; human.
DR   AGR; HGNC:25024; -.
DR   CTD; 57415; -.
DR   GeneCards; CEP15; -.
DR   HGNC; HGNC:25024; CEP15.
DR   HPA; ENSG00000114405; Tissue enhanced (brain).
DR   neXtProt; NX_Q9HBI5; -.
DR   OpenTargets; ENSG00000114405; -.
DR   PharmGKB; PA134883066; -.
DR   VEuPathDB; HostDB:ENSG00000114405; -.
DR   eggNOG; ENOG502S7A9; Eukaryota.
DR   GeneTree; ENSGT00390000005214; -.
DR   HOGENOM; CLU_133336_0_0_1; -.
DR   InParanoid; Q9HBI5; -.
DR   OMA; IGVENEN; -.
DR   OrthoDB; 5321100at2759; -.
DR   PhylomeDB; Q9HBI5; -.
DR   TreeFam; TF335879; -.
DR   PathwayCommons; Q9HBI5; -.
DR   SignaLink; Q9HBI5; -.
DR   BioGRID-ORCS; 57415; 8 hits in 1118 CRISPR screens.
DR   ChiTaRS; C3orf14; human.
DR   GenomeRNAi; 57415; -.
DR   Pharos; Q9HBI5; Tdark.
DR   PRO; PR:Q9HBI5; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q9HBI5; Protein.
DR   Bgee; ENSG00000114405; Expressed in pons and 194 other cell types or tissues.
DR   ExpressionAtlas; Q9HBI5; baseline and differential.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   InterPro; IPR028006; CEP15-like.
DR   PANTHER; PTHR14286; GENE, 49355-RELATED; 1.
DR   PANTHER; PTHR14286:SF2; SIMILAR TO HT021; 1.
DR   Pfam; PF15134; DUF4570; 1.
DR   Genevisible; Q9HBI5; HS.
PE   2: Evidence at transcript level;
KW   Cell projection; Reference proteome.
FT   CHAIN           1..128
FT                   /note="Centrosomal protein 15"
FT                   /id="PRO_0000089388"
SQ   SEQUENCE   128 AA;  15007 MW;  9046B046B0ABD901 CRC64;
     MTSLFAQEIR LSKRHEEIVS QRLMLLQQME NKLGDQHTEK ASQLQTVETA FKRNLSLLKD
     IEAAEKSLQT RIHPLPRPEV VSLETRYWAS VEEYIPKWEQ FLLGRAPYPF AVENQNEAEN
     TIQNEAQR
//