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Protein

Gamma-parvin

Gene

PARVG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.By similarity

GO - Molecular functioni

  • actin binding Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton reorganization Source: InterPro
  • cell-matrix adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-parvin
Gene namesi
Name:PARVG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:14654. PARVG.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB
  • focal adhesion Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32952.

Chemistry

ChEMBLiCHEMBL5793.

Polymorphism and mutation databases

DMDMi20143882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Gamma-parvinPRO_0000121585Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9HBI0.
MaxQBiQ9HBI0.
PaxDbiQ9HBI0.
PRIDEiQ9HBI0.
TopDownProteomicsiQ9HBI0-2. [Q9HBI0-2]

PTM databases

iPTMnetiQ9HBI0.
PhosphoSiteiQ9HBI0.

Expressioni

Tissue specificityi

Expressed predominantly in lymphoid organs, including spleen, thymus, lymph node, bone marrow and peripheral blood leukocytes and moderately in the digestive tract, including stomach, duodenum, jejunum, ileum, ileocecum and appendix, as well as in lung and liver. Also expressed in tumors, but at a lower level than in the corresponding normal tissues.1 Publication

Gene expression databases

BgeeiQ9HBI0.
CleanExiHS_PARVG.
ExpressionAtlasiQ9HBI0. baseline and differential.
GenevisibleiQ9HBI0. HS.

Organism-specific databases

HPAiHPA031834.

Interactioni

Subunit structurei

Interacts with integrin-linked protein kinase and actin.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-3921217,EBI-717810
ILKQ134185EBI-3921217,EBI-747644
KLHL32Q5THT13EBI-3921217,EBI-10247181
MEOX2A4D1273EBI-3921217,EBI-10172134
RELQ048643EBI-3921217,EBI-307352
USHBP1Q8N6Y03EBI-3921217,EBI-739895

GO - Molecular functioni

  • actin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122059. 17 interactions.
IntActiQ9HBI0. 10 interactions.
MINTiMINT-6944620.
STRINGi9606.ENSP00000391453.

Structurei

3D structure databases

ProteinModelPortaliQ9HBI0.
SMRiQ9HBI0. Positions 198-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 151108CH 1PROSITE-ProRule annotationAdd
BLAST
Domaini210 – 317108CH 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the parvin family.Curated
Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3631. Eukaryota.
ENOG410XQWH. LUCA.
GeneTreeiENSGT00390000009673.
HOGENOMiHOG000247027.
HOVERGENiHBG053517.
InParanoidiQ9HBI0.
KOiK06275.
OMAiTSRKDPK.
OrthoDBiEOG7CCBS2.
PhylomeDBiQ9HBI0.
TreeFamiTF314025.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR028433. Parvin.
[Graphical view]
PANTHERiPTHR12114. PTHR12114. 1 hit.
PfamiPF00307. CH. 2 hits.
[Graphical view]
PIRSFiPIRSF039131. Parvin. 1 hit.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS50021. CH. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HBI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPEFLYDLL QLPKGVEPPA EEELSKGGKK KYLPPTSRKD PKFEELQKVL
60 70 80 90 100
MEWINATLLP EHIVVRSLEE DMFDGLILHH LFQRLAALKL EAEDIALTAT
110 120 130 140 150
SQKHKLTVVL EAVNRSLQLE EWQAKWSVES IFNKDLLSTL HLLVALAKRF
160 170 180 190 200
QPDLSLPTNV QVEVITIEST KSGLKSEKLV EQLTEYSTDK DEPPKDVFDE
210 220 230 240 250
LFKLAPEKVN AVKEAIVNFV NQKLDRLGLS VQNLDTQFAD GVILLLLIGQ
260 270 280 290 300
LEGFFLHLKE FYLTPNSPAE MLHNVTLALE LLKDEGLLSC PVSPEDIVNK
310 320 330
DAKSTLRVLY GLFCKHTQKA HRDRTPHGAP N
Length:331
Mass (Da):37,485
Last modified:March 1, 2001 - v1
Checksum:i392BFCDD0B7D86A4
GO
Isoform 2 (identifier: Q9HBI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-273: LH → IS
     274-331: Missing.

Note: No experimental confirmation available.
Show »
Length:273
Mass (Da):31,042
Checksum:iD9BCB325BE989A1A
GO
Isoform 3 (identifier: Q9HBI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-187: S → R
     188-331: Missing.

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):21,439
Checksum:i8B738B944A464753
GO
Isoform 4 (identifier: Q9HBI0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVPAKEQVPGRCDSTQRCFPGPSNWTGAGGRAGSQPFVGDGTLGTPNFCWDHKEKRAAESQLQAWEAM
     49-70: VLMEWINATLLPEHIVVRSLEE → HTWPSPVTGTGDTICGLARKTW
     71-331: Missing.

Show »
Length:137
Mass (Da):15,114
Checksum:iA8F3E321CE899506
GO
Isoform 5 (identifier: Q9HBI0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-70: VLMEWINATLLPEHIVVRSLEE → HTWPSPVTGTGDTICGLARKTW
     71-331: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:70
Mass (Da):7,926
Checksum:i7D7626A275E126C0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 5 (identifier: Q9HBI0-5)
Sequence conflicti63 – 631C → R in AK307294 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MVPAKEQVPGRCDSTQRCFP GPSNWTGAGGRAGSQPFVGD GTLGTPNFCWDHKEKRAAES QLQAWEAM in isoform 4. 1 PublicationVSP_045145
Alternative sequencei49 – 7022VLMEW…RSLEE → HTWPSPVTGTGDTICGLARK TW in isoform 4 and isoform 5. 1 PublicationVSP_045146Add
BLAST
Alternative sequencei71 – 331261Missing in isoform 4 and isoform 5. 1 PublicationVSP_045147Add
BLAST
Alternative sequencei187 – 1871S → R in isoform 3. 1 PublicationVSP_012953
Alternative sequencei188 – 331144Missing in isoform 3. 1 PublicationVSP_012954Add
BLAST
Alternative sequencei272 – 2732LH → IS in isoform 2. 1 PublicationVSP_004540
Alternative sequencei274 – 33158Missing in isoform 2. 1 PublicationVSP_004541Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237772 mRNA. Translation: AAG27174.1.
AL590887 mRNA. Translation: CAC37414.1.
AL355092 mRNA. Translation: CAB90188.1.
CR456480 mRNA. Translation: CAG30366.1.
AK293360 mRNA. Translation: BAG56876.1.
AK307294 mRNA. No translation available.
AL031595 Genomic DNA. Translation: CAI22314.1.
BC034406 mRNA. Translation: AAH34406.1.
CCDSiCCDS14057.1. [Q9HBI0-1]
RefSeqiNP_001131077.1. NM_001137605.2. [Q9HBI0-1]
NP_071424.1. NM_022141.6. [Q9HBI0-1]
XP_005261759.1. XM_005261702.2. [Q9HBI0-1]
UniGeneiHs.658995.
Hs.666944.

Genome annotation databases

EnsembliENST00000356909; ENSP00000349378; ENSG00000138964. [Q9HBI0-3]
ENST00000415224; ENSP00000416761; ENSG00000138964. [Q9HBI0-3]
ENST00000422871; ENSP00000391453; ENSG00000138964. [Q9HBI0-1]
ENST00000444313; ENSP00000391583; ENSG00000138964. [Q9HBI0-1]
GeneIDi64098.
KEGGihsa:64098.
UCSCiuc003bep.4. human. [Q9HBI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237772 mRNA. Translation: AAG27174.1.
AL590887 mRNA. Translation: CAC37414.1.
AL355092 mRNA. Translation: CAB90188.1.
CR456480 mRNA. Translation: CAG30366.1.
AK293360 mRNA. Translation: BAG56876.1.
AK307294 mRNA. No translation available.
AL031595 Genomic DNA. Translation: CAI22314.1.
BC034406 mRNA. Translation: AAH34406.1.
CCDSiCCDS14057.1. [Q9HBI0-1]
RefSeqiNP_001131077.1. NM_001137605.2. [Q9HBI0-1]
NP_071424.1. NM_022141.6. [Q9HBI0-1]
XP_005261759.1. XM_005261702.2. [Q9HBI0-1]
UniGeneiHs.658995.
Hs.666944.

3D structure databases

ProteinModelPortaliQ9HBI0.
SMRiQ9HBI0. Positions 198-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122059. 17 interactions.
IntActiQ9HBI0. 10 interactions.
MINTiMINT-6944620.
STRINGi9606.ENSP00000391453.

Chemistry

ChEMBLiCHEMBL5793.

PTM databases

iPTMnetiQ9HBI0.
PhosphoSiteiQ9HBI0.

Polymorphism and mutation databases

DMDMi20143882.

Proteomic databases

EPDiQ9HBI0.
MaxQBiQ9HBI0.
PaxDbiQ9HBI0.
PRIDEiQ9HBI0.
TopDownProteomicsiQ9HBI0-2. [Q9HBI0-2]

Protocols and materials databases

DNASUi64098.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356909; ENSP00000349378; ENSG00000138964. [Q9HBI0-3]
ENST00000415224; ENSP00000416761; ENSG00000138964. [Q9HBI0-3]
ENST00000422871; ENSP00000391453; ENSG00000138964. [Q9HBI0-1]
ENST00000444313; ENSP00000391583; ENSG00000138964. [Q9HBI0-1]
GeneIDi64098.
KEGGihsa:64098.
UCSCiuc003bep.4. human. [Q9HBI0-1]

Organism-specific databases

CTDi64098.
GeneCardsiPARVG.
H-InvDBHIX0016566.
HGNCiHGNC:14654. PARVG.
HPAiHPA031834.
MIMi608122. gene.
neXtProtiNX_Q9HBI0.
PharmGKBiPA32952.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3631. Eukaryota.
ENOG410XQWH. LUCA.
GeneTreeiENSGT00390000009673.
HOGENOMiHOG000247027.
HOVERGENiHBG053517.
InParanoidiQ9HBI0.
KOiK06275.
OMAiTSRKDPK.
OrthoDBiEOG7CCBS2.
PhylomeDBiQ9HBI0.
TreeFamiTF314025.

Miscellaneous databases

GeneWikiiPARVG.
GenomeRNAii64098.
NextBioi65928.
PROiQ9HBI0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HBI0.
CleanExiHS_PARVG.
ExpressionAtlasiQ9HBI0. baseline and differential.
GenevisibleiQ9HBI0. HS.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR028433. Parvin.
[Graphical view]
PANTHERiPTHR12114. PTHR12114. 1 hit.
PfamiPF00307. CH. 2 hits.
[Graphical view]
PIRSFiPIRSF039131. Parvin. 1 hit.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS50021. CH. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily."
    Olski T.M., Noegel A.A., Korenbaum E.
    J. Cell Sci. 114:525-538(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
  2. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."
    Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
    Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Fetal brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
    Tissue: Spleen and Urinary bladder.
  5. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Lung and Testis.
  7. "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans."
    Korenbaum E., Olski T.M., Noegel A.A.
    Gene 279:69-79(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPARVG_HUMAN
AccessioniPrimary (citable) accession number: Q9HBI0
Secondary accession number(s): B4DDW5
, E7EVM6, Q9BQX5, Q9NSG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: April 13, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.